Environmental Pollution最新文献

{"title":"Gut microbiota combined with metabolome dissects Fluorene-9-bisphenol exposure-induced male reproductive toxicity","authors":"Danni Jiang, Yang Yang, Xiaojuan Han, Qianni Li, Jun Jiao, Yingxiu Ma, Lan Chao","doi":"10.1016/j.envpol.2024.125339","DOIUrl":"https://doi.org/10.1016/j.envpol.2024.125339","url":null,"abstract":"A major alternative to bisphenol A (BPA), fluorene-9-bisphenol (BHPF) has been shown to cause multiorgan toxicity. However, its reproductive toxicity and the underlying biological mechanism remain largely unknown. Recently, changes in the gut microbiota and metablome caused by environmental contaminant exposure and their potential impact on male reproductive health have been of great concern. Therefore, we aimed to elucidate the underlying mechanism of BHPF-related fertility impairment by integrating metabolome and microbiome analysis. In the present study, we showed that BHPF exposure caused testicular dysfunction with impaired spermatogenesis and disrupted steroid hormone synthesis. Mechanistically, altered gut microbiota and metabolites were revealed by 16S rDNA sequencing and untargeted metabolomics analysis. Subsequent multi-omics combination analysis revealed a strong correlation between altered microbiota and lipid metabolites. We also found a strong relationship between lipid metabolites and sperm parameters such as sperm concentration, sperm motility, etc. Most importantly, these findings provide new insights into the mechanistic scenario underlying BHPF-induced fertility toxicity, that disrupted lipid metabolism caused by gut microbiota dysbiosis may be a reason for reproductive impairment caused by BHPF exposure.","PeriodicalId":311,"journal":{"name":"Environmental Pollution","volume":"99 1","pages":""},"PeriodicalIF":8.9,"publicationDate":"2024-11-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142665225","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"High-resolution Spatiotemporal Prediction of PM2.5 Concentration based on Mobile Monitoring and Deep Learning","authors":"Yi-Zhou Wang, Hong-Di He, Hai-Chao Huang, Jin-Ming Yang, Zhong-Ren Peng","doi":"10.1016/j.envpol.2024.125342","DOIUrl":"https://doi.org/10.1016/j.envpol.2024.125342","url":null,"abstract":"Obtaining the high-resolution distribution characteristics of urban air pollutants is crucial for effective pollution control and public health. In order to fulfill it, mobile monitoring offers a novel and practical approach compared to traditional fixed monitoring methods. However, the sparsity of mobile monitoring data still makes it a challenge to recover the high-resolution pollutant concentration across an entire area. To tackle the sparsity issue and fulfill a prediction of the spatiotemporal distribution of PM_2.5, a high-resolution urban PM_2.5 prediction method was proposed based on mobile monitoring data in this study. This method enables prediction with a spatial resolution of 500m × 500m and a temporal resolution of 1 hour. First, a Light Gradient Boosting Machine (LightGBM) was trained using mobile monitoring of PM_2.5 concentration and exogenous features to obtain complete spatiotemporal PM_2.5 concentration. Second, a model consisting of Convolutional Neural Network and Transformer (CNN-Transformer) with a customised loss function was established to predict high-resolution PM_2.5 concentration based on complete spatiotemporal data. The method was validated using real-world data collected from Cangzhou, China. The numerical results from cross-validation showed an R² of 0.925 for imputation and 0.887 for prediction, demonstrating this method is suitable for high-resolution spatiotemporal prediction of PM_2.5 concentration based on mobile monitoring data.","PeriodicalId":311,"journal":{"name":"Environmental Pollution","volume":"6 1","pages":""},"PeriodicalIF":8.9,"publicationDate":"2024-11-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142665226","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Bacteriological safety and quality of composted products from animal, urban or sewage sludge wastes","authors":"Ivone Vaz-Moreira, Angelo D’Arnese, Maurice Knoll, A. Margarida Teixeira, Joana Bastos Barbosa, Paula Teixeira, Célia M. Manaia","doi":"10.1016/j.envpol.2024.125329","DOIUrl":"https://doi.org/10.1016/j.envpol.2024.125329","url":null,"abstract":"This study investigated the presence of culturable bacterial pathogens, and antibiotic resistance and associated genes (quantitative PCR) in commercially available composted products from animal excrements or manure (n=7), urban wastes (n=1) or (sewage sludge) (n=1). Metals quantification and 16S rRNA-based bacterial community composition analyses supported the results to infer potential risks to downstream environments (e.g., soils). <em>Bacilli</em> and <em>Actinomycetes</em> were the dominant bacterial classes in seven composts, while two were dominated by different classes of <em>Pseudomonadota</em> or the class <em>Bacteroidia</em>. <em>Salmonella</em> spp. was not detected in all composts, meeting recommended quality criteria, while <em>Escherichia coli</em> and <em>Listeria monocytogenes</em> were only detected in the sewage sludge compost. The antibiotic resistance genes <em>ermB</em> and <em>ermF</em> were detected in most of the composts, and the antibiotic resistance gene <em>sul1</em> and the <em>intI1</em> gene (proxy for antibiotic resistance recombination) in all composts in the range of 6-9 log gene copy number/g dry weight. <em>Listeria</em> spp. and the gene <em>bla</em>_{<em>CTX</em>-M} were detected only in chicken/poultry composts suggesting increased risk. All composts, except the urban waste compost, presented at least one metal (zinc, copper, and/or cadmium) above the recommended value. The genes <em>uidA</em>, <em>crAssphage</em>, <em>ermB</em> and <em>bla</em>_{<em>CTX</em>-M} were negatively correlated with the abundance of total heterotrophs and moisture content, and the genes <em>intI1</em> and <em>sul1</em> were negatively correlated with the concentration of the metals Cr, Ni and Pb. Overall, the urban waste compost presented the best quality, exhibiting the lowest antibiotic resistance load. These findings alert for the fact that composts may contribute to the dissemination of antibiotic resistance, highlighting the need of regular assessment. It is suggested that multiple factors, including the raw materials, may influence the safety of the final compost, and the knowledge of the variables affecting compost safety need to be thoroughly investigated and understood.","PeriodicalId":311,"journal":{"name":"Environmental Pollution","volume":"43 1","pages":""},"PeriodicalIF":8.9,"publicationDate":"2024-11-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142642621","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Analysis of Microplastic Contamination and Associated Human Health Risks in Clarias gariepinus and Oreochromis niloticus from Kubanni Reservoir, Zaria Nigeria","authors":"Maria Onma Onaji, David S. Abolude, Shuaibu Akpai Abdullahi, Lucas Del Bianco Faria, Mathias Ahii Chia","doi":"10.1016/j.envpol.2024.125328","DOIUrl":"https://doi.org/10.1016/j.envpol.2024.125328","url":null,"abstract":"Environmental safety has become a major concern in recent years due to the global increase in microplastic pollution. These ubiquitous, tiny, and potentially toxic plastic particles enter aquatic environments through weathering of larger plastics and the release of microbeads. Although numerous studies have focused on microplastic pollution in developed regions, information from developing countries remains limited. This study assessed the presence of MPs and associated oxidative stress responses in two commercial fish species, <em>Clarias gariepinus</em> (Catfish) and <em>Oreochromis niloticus</em> (Nile Tilapia), from Kubanni reservoir, Zaria, Nigeria, over six months spanning both the dry and rainy seasons. Fibers were identified as the most abundant MP particles, followed by fragments, films, and beads, in the order of fibers &gt; fragments &gt; films &gt; beads. The highest fiber concentrations were recorded in the gills, with <em>Clarias garipinus</em> showing 11.5 MP items/individual and <em>Oreochromis niloticus</em> showing 22.5 MP items/individual. Black microplastics were predominant, and the most common ingested MP ranged from 1.0 to 2.0 mm. The primary polymers identified were polypropylene and polyethylene terephthalate. Evidence of oxidative stress and cellular damage was observed in the gills, liver, and dorsal muscles of both fish species, which correlated with MPs ingestion. According to recommendations from the European Food Safety Authority regarding fish consumption by children and adults, individuals consuming <em>Clarias gariepinus</em> and <em>Oreochromis niloticus</em> from the Kubanni reservoir may be exposed to between 70 and 700 MP items/organ. The risk associated with consuming MPs found in fish gills and guts was notably higher, posing significant concerns for human health. This study provides insights into microplastic contamination in commercially important fish from the Kubanni Reservoir and highlights the environmental and public health risks associated with consuming contaminated fish from this ecosystem.","PeriodicalId":311,"journal":{"name":"Environmental Pollution","volume":"38 1","pages":""},"PeriodicalIF":8.9,"publicationDate":"2024-11-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142642619","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Potential Source Contribution Function Coupled with Mass Spectrometry Detection to Identify Source of Atmospheric Polyethylene Terephthalate","authors":"Hanling Yang, Junjie Zhang, Zhiwanxin Li, Jian Pu, Chu Peng, Chunguang Liu, Lei Wang","doi":"10.1016/j.envpol.2024.125325","DOIUrl":"https://doi.org/10.1016/j.envpol.2024.125325","url":null,"abstract":"Source identification of atmospheric microplastics (MPs) is crucial for the development of mitigation policies. Compared with wind directions or backward trajectories of air masses, the potential source contribution function (PSCF) analysis identifies more comprehensive sources of atmospheric particles. However, conducting PSCF analysis requires hourly pollutant concentration data, which cannot be met by the atmospheric MPs abundance obtained through commonly used methods. In this study, total suspended particles (TSP) samples were collected hourly and the concentrations of atmospheric polyethylene terephthalate (PET) were detected using a liquid chromatography-tandem mass spectrometry. Atmospheric concentrations of PET MPs were 112.9 ± 39.04 ng/m³ (average ± SD). Based on the hourly backward trajectories of air masses and the varied PET concentrations at the sampling site, potential sources of atmospheric PET were identified by PSCF analysis. The backward trajectory-based method indicates that atmospheric PET of the target site in this study primarily originates from dry farmlands. In comparison, both the residential areas and the dry farmlands were identified by PSCF as major sources of atmospheric PET at the receptor site. In contrast, both the backward-trajectory based method and PSCF analysis indicate that TSP mainly originates from the dry farmlands near the sampling site. This indicates that atmospheric PET in urban areas may have different sources from those of TSP, and PSCF is a suitable method for identifying sources of atmospheric PET.","PeriodicalId":311,"journal":{"name":"Environmental Pollution","volume":"247 1","pages":""},"PeriodicalIF":8.9,"publicationDate":"2024-11-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142642622","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Nanosilica and salicylic acid synergistically regulate cadmium toxicity in rice","authors":"Sajid Muhammad, Zaid Ulhassan, Raheel Munir, Muhammad Umair Yasin, Faisal Islam, Kangni Zhang, Weiqi Chen, Mehmood Jan, Muhammad Afzal, Ali Muhammad, Fakhir Hannan, Weijun Zhou","doi":"10.1016/j.envpol.2024.125331","DOIUrl":"https://doi.org/10.1016/j.envpol.2024.125331","url":null,"abstract":"Cadmium (Cd) toxicity negatively impacts plant health and productivity. Nanosilica (SiO₂NPs) and salicylic acid (SA) enhance plant performance and alleviate heavy metals stress. Yet, their combined effects against Cd-toxicity in rice remained less-explored. Thus, a hydroponic study investigated the individual and combined effects of SiO₂NPs and SA on Cd-stress mitigation in rice at physio-biochemical, cellular, and molecular levels. Results indicated that Cd-alone treatment caused a significant reduction in rice growth and biomass and photosynthetic efficiency, which was associated with oxidative damage caused by enhanced Cd-accumulation in plant tissues. Cd-induction also potentiated its phytotoxicity by triggering enzymatic antioxidants against the extra production of reactive oxygen species (ROS). The addition of SiO₂NPs and/or SA markedly minimized the Cd-induced toxicity by reducing Cd-bioaccumulation (42‒56%), protecting photosynthetic efficiency, which were directly correlated with seedling biomass and restored cellular structures (leaf ultrastructure and surface morphology). The combined application of SiO₂NPs and SA was more effective in activating antioxidant enzymes, phytohormones biosynthesis, and reducing oxidative damages caused by Cd than sole application. This was evident in the decreased production of ROS, malondialdehyde contents (29‒37%), and recovered membrane stability. Moreover, SiO₂NPs and/or SA relieved Cd-bioaccumulation (41‒56%) by downregulating the Cd-related transporter genes (<em>OsNramp1</em>, <em>OsNramp5</em>, <em>OsHMA2,</em> and <em>OsHMA3</em>). Altogether, the cellular Cd-accumulation, photosynthesis, antioxidant defense, and phytohormones against oxidative stress can be ideal markers for cultivating rice in Cd-contaminated soils.","PeriodicalId":311,"journal":{"name":"Environmental Pollution","volume":"36 1","pages":""},"PeriodicalIF":8.9,"publicationDate":"2024-11-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142642617","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Onboard measurements of organic vapor emissions from river vessels under various operational conditions","authors":"Mengxue Tong, Yanli Zhang, Mei Li, Qi Wang, Xiao Tian, Dan Zhang, Aoqi Ge, Wei Song, Xin Xiong, Yinong You, Yongjang Xu, Yihua Huang, Xin Yang, Xinming Wang","doi":"10.1016/j.envpol.2024.125332","DOIUrl":"https://doi.org/10.1016/j.envpol.2024.125332","url":null,"abstract":"The emission factors and characteristics of pollutants from river vessels are critical for understanding the environmental impact of ship emissions, particularly in inland waterways. However, research gaps remain regarding emissions of volatile organic compounds (VOCs) and intermediate-volatility organic compounds (IVOCs) from river vessels. In this study, we collected and analyzed organic vapor emissions, including non-methane hydrocarbon (NMHCs), oxygenated volatile organic compounds (OVOCs) and IVOCs, from three river vessels under different operating conditions. The results show that the average emission factors of NMHCs, and IVOCs from river vessels are significantly higher than those from ocean-going vessels. Inland waterways’ proximity to residential areas increases the risk of pollutant transport to urban environments, heightening the importance of managing river vessel emissions. Notably, older auxiliary engines displayed higher organic vapor emissions compared to main engines, underscoring the need for better control measures for aging engines. By analyzing the emission characteristics of organic vapors from river vessels, it was found that, unlike other pollution sources where C12 n-alkanes are the major contributors of IVOCs, the contributions of C12-C15 n-alkanes in river vessel exhaust are similar, with C14 n-alkane having the highest contribution. OVOCs constituted more than 50% to ozone formation potentials of organic vapors, while IVOCs were responsible for over 90% of the secondary organic aerosol (SOA) formation. Given these findings, targeted efforts to reduce OVOCs and IVOCs emissions from river vessels should prioritized to mitigate their environmental impact.","PeriodicalId":311,"journal":{"name":"Environmental Pollution","volume":"25 1","pages":""},"PeriodicalIF":8.9,"publicationDate":"2024-11-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142642620","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Interaction Between Root Exudates and PFOS Mobility: Effects on Rhizosphere Microbial Health in Wetland Ecosystems","authors":"Bianhe Lu, Peifang Wang, Yueming Zhu, Jing Hu, Jin Qian, Yuanyuan Huang, Junwei Shen, Sijing Tang, Yin Liu","doi":"10.1016/j.envpol.2024.125324","DOIUrl":"https://doi.org/10.1016/j.envpol.2024.125324","url":null,"abstract":"Perfluorooctanesulfonate (PFOS), a persistent organic pollutant, poses significant ecological risks. This study investigates the effects of PFOS on rhizosphere microbial communities of two wetland plants, <em>Lythrum salicaria</em> (LS) and <em>Phragmites communis</em> (PC). We conducted microcosm experiments to analyze the physiological status of soil microbes under varying PFOS concentrations and examined the role of root exudates in modulating PFOS mobility. Flow cytometry and soil respiration measurements revealed that PFOS exposure increased microbial mortality, with differential impacts observed between LS and PC rhizospheres. LS root exudates intensified microbial stress, whereas PC exudates mitigated PFOS toxicity. Thin-layer chromatography indicated that LS exudates decreased PFOS mobility, leading to higher local concentrations and increased microbial toxicity, while PC exudates enhanced PFOS mobility, reducing its local impact. Fourier-transform infrared spectroscopy and excitation-emission matrix fluorescence spectroscopy of root exudates identified compositional shifts under PFOS stress, highlighting distinct defense strategies in LS and PC. These findings underscore the importance of plant-microbe interactions and root exudate composition in determining microbial resilience to PFOS contamination.","PeriodicalId":311,"journal":{"name":"Environmental Pollution","volume":"17 1","pages":""},"PeriodicalIF":8.9,"publicationDate":"2024-11-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142642618","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Shallow Shotgun Sequencing of Healthcare Waste Reveals Plastic-Eating Bacteria with Broad-Spectrum Antibiotic Resistance Genes","authors":"Shing Wei Siew, Mohamad Hazwan Fikri Khairi, Norhisham Abdul Hamid, Mohd Fazli Farida Asras, Hajar Fauzan Ahmad","doi":"10.1016/j.envpol.2024.125330","DOIUrl":"https://doi.org/10.1016/j.envpol.2024.125330","url":null,"abstract":"The burgeoning crises of antimicrobial resistance and plastic pollution are converging in healthcare settings, presenting a complex challenge to global health. This study investigates the microbial populations in healthcare waste to understand the extent of antimicrobial resistance and the potential for plastic degradation by bacteria. Our metagenomic analysis, using both amplicon and shallow shotgun sequencing, provided a comprehensive view of the taxonomic diversity and functional capacity of the microbial consortia. The viable bacteria in healthcare waste samples were analyzed employing full-length 16S rRNA sequencing, revealing a diverse bacterial community dominated by <em>Firmicutes</em> and <em>Proteobacteria</em> phyla. Notably, <em>Proteus mirabilis</em> VFC3/3 and <em>Pseudomonas</em> sp. VFA2/3 were detected, while <em>Stenotrophomonas maltophilia</em> VFV3/2 surfaced as the predominant species, holding implications for the spread of hospital-acquired infections and antimicrobial resistance. Antibiotic susceptibility testing identified multidrug-resistant strains conferring antimicrobial genes, including the broad-spectrum antibiotic carbapenem, underscoring the critical need for improved waste management and infection control measures. Remarkably, we found genes linked to the breakdown of plastic that encoded for enzymes of the esterase, depolymerase, and oxidoreductase classes. This suggests that specific bacteria found in medical waste may be able to reduce the amount of plastic pollution that comes from biological and medical waste. The information is helpful in formulating strategies to counter the combined problems of environmental pollution and antibiotic resistance. This study emphasises the importance of monitoring microbial communities in hospital waste in order to influence waste management procedures and public health policy. The findings highlight the need for a multidisciplinary approach to mitigate the risks associated with antimicrobial resistance and plastic waste, especially in hospital settings where they intersect most acutely.","PeriodicalId":311,"journal":{"name":"Environmental Pollution","volume":"75 1","pages":""},"PeriodicalIF":8.9,"publicationDate":"2024-11-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142642914","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Microplastics accumulated in breast cancer patients lead to mitophagy via ANXA2-mediated endocytosis and IL-17 signaling pathway.","authors":"Ziying Tian, Boni Ding, Yilin Guo, Jieyu Zhou, Su Jiang, Jiaxue Lu, Nan Li, Xiao Zhou, Wenling Zhang","doi":"10.1016/j.envpol.2024.125321","DOIUrl":"10.1016/j.envpol.2024.125321","url":null,"abstract":"<p><p>Breast cancer (BC) is the most common malignancy in women and the leading cause of cancer death. Microplastics (MPs) are plastic fragments with a diameter of less than 5 mm, easily ingested by organisms. Although MPs have been reported to enter the human body through diet, surgery, etc., whether MPs accumulate in BC and their effects have been largely unknown. Our study revealed a significant accumulation of MPs in BC patient samples. MPs pull-down experiments and mass spectrometry (MS) studies showed that MPs bound to annexin A2 (ANXA2) and were endocytosed into cells. This process resulted in mitochondrial damage and subsequent induction of mitophagy. Furthermore, after binding to ANXA2, MPs regulated mitophagy by inhibiting IL-17 exocytosis. These findings revealed the mechanism of toxic effects of MPs in patients with BC, clarified the molecular mechanism of ANXA2-IL-17 signaling pathway causing mitochondrial damage by MPs, and suggested the potential toxic effects and toxicological mechanisms of MPs.</p>","PeriodicalId":311,"journal":{"name":"Environmental Pollution","volume":" ","pages":"125321"},"PeriodicalIF":7.6,"publicationDate":"2024-11-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142666581","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}