Environmental Pollution最新文献

{"title":"Adverse associations of pre-pregnancy exposure to PM2.5 and its components with fetal growth alleviated by residential greenness: a prospective cohort study","authors":"Si-Wei Dai ,&nbsp;Zhen-Hua Li ,&nbsp;Si-Yu Zhang ,&nbsp;Chen Sun ,&nbsp;Jia-Hui Li ,&nbsp;Chun-Yong Wang ,&nbsp;Xiao-Yu Zhao ,&nbsp;Hai-Yang Weng ,&nbsp;Kai Huang ,&nbsp;Mao-Lin Chen ,&nbsp;Guo-Peng Gao ,&nbsp;Cheng-Yang Hu ,&nbsp;Xiu-Jun Zhang","doi":"10.1016/j.envpol.2025.126272","DOIUrl":"10.1016/j.envpol.2025.126272","url":null,"abstract":"<div><div>Maternal exposure to fine particulate matter (PM_2.5) and residential greenness both influence fetal growth. No previous studies have examined their sex-specific and interaction effects. We aim to evaluate the sex-specific effects in these associations and exposure interactions. This study involved 1,275 mother–child pairs enrolled in the Ma'anshan birth cohort in China. Pre-pregnancy exposure to PM_2.5 and its components was assessed using a spatiotemporal model based on maternal addresses, while residential greenness was estimated through the normalized difference vegetation index (NDVI) based on satellite data. Fetal parameters—including biparietal diameter (BPD), head circumference (HC), abdominal circumference (AC), femur length (FL), and estimated fetal weight (EFW)—were measured during pregnancy via ultrasound. To examine associations between these exposures and both continuous and categorical outcomes, generalized estimating equations (GEE) and generalized linear regression were applied. Subgroup analyses were conducted to evaluate sex-specific effects. Pre-pregnancy exposure to PM_2.5, OM, BC, SO₄²⁻, NH₄⁺, and NO₃⁻ was correlated with decreased Z-scores of fetal parameters (BPD, FL, EFW, AC) during the second trimester, particularly in male fetuses. In the third trimester, we found that the Z-scores of AC (0.081, 95% CI: 0.001, 0.160) and EFW (0.097, 95% CI: 0.008, 0.185) increased with each interquartile range (IQR) increase in residential greenness. We observed the effect modification of PM_2.5 and its components on the relationship between residential greenness and fetal growth in utero. Residential greenness can mitigate the adverse effects of PM_2.5 and its components prior to pregnancy on fetal growth. Our findings suggest that increased residential greenness during pregnancy preparation may help alleviate air pollution's detrimental effects on fetal growth.</div></div>","PeriodicalId":311,"journal":{"name":"Environmental Pollution","volume":"374 ","pages":"Article 126272"},"PeriodicalIF":7.6,"publicationDate":"2025-04-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143846783","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association of ambient ozone with time to pregnancy and the modifying effect of ambient temperature: a population-based cohort study","authors":"Bingxue Wu ,&nbsp;Tao Wang ,&nbsp;Yan Zhang ,&nbsp;Yuyan Li ,&nbsp;Cai Kong ,&nbsp;Yishi Jiang ,&nbsp;Xiangjing Song ,&nbsp;Xing Chen ,&nbsp;Zhengyuan Xie ,&nbsp;Hanfeng Ye ,&nbsp;Lin Feng ,&nbsp;Zigao Zhao ,&nbsp;Yan Che","doi":"10.1016/j.envpol.2025.126269","DOIUrl":"10.1016/j.envpol.2025.126269","url":null,"abstract":"<div><div>Research on the impact of ozone (O₃) on fecundability has been inconclusive, lacking evidence examining the lagged pattern of ozone exposure and temperature modification. Current studies have predominantly been conducted in North America and Europe, leaving a gap in research from the Asian population. This population-based prospective cohort study involved 594,110 couples in Yunnan Province, China, enrolled in the National Free Preconception Health Examination Project. We calculated time-varying cycle-specific O₃ concentration across 1–12 menstrual cycles before conception, according to each female's menstrual cycle length and residential addresses. Time to pregnancy was used as an outcome indicator. A discrete-time Cox regression model integrated with a distributed lag model (DLM) was employed for analysis. We observed that O₃ exposure was negatively associated with fecundability, with the effect diminishing over time relative to conception. The first menstrual cycle before conception appeared most sensitive to O₃ exposure, showing a 6.2 % decrease (HR: 0.938; 95 % CI: 0.936 to 0.941) in fecundability per one IQR increase of O₃. Combined exposure to O₃ and ambient temperature may exert a synergistic effect. The modifying effect of temperature was most pronounced in the first cycle before conception, with HRs of 0.891 (95 % CI: 0.886 to 0.895), 0.859 (95 % CI: 0.853 to 0.865), and 0.833 (95 % CI: 0.826 to 0.840) under low-, median-, and high-temperature conditions, respectively. Targeted policy interventions are needed to mitigate the dual impact of air pollution and rising temperatures.</div></div>","PeriodicalId":311,"journal":{"name":"Environmental Pollution","volume":"374 ","pages":"Article 126269"},"PeriodicalIF":7.6,"publicationDate":"2025-04-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143847034","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exposure to toxic metal(loid)s via breastmilk and stunting in infants living in the Lake Atitlán watershed, Guatemala","authors":"Sandra Rodríguez Quintana ,&nbsp;Frank A. von Hippel ,&nbsp;Mónica Orozco ,&nbsp;Noel Solomons ,&nbsp;Dean Billheimer ,&nbsp;Maria A. Sans-Fuentes ,&nbsp;Mary Kay Amistadi ,&nbsp;Sam Sneed ,&nbsp;Paloma Beamer ,&nbsp;Alejandra Zamora ,&nbsp;Eileen Rivera ,&nbsp;Ruth Forsten ,&nbsp;Preet Gandhi","doi":"10.1016/j.envpol.2025.126273","DOIUrl":"10.1016/j.envpol.2025.126273","url":null,"abstract":"<div><div>Guatemala has the highest child stunting prevalence in the Americas and is ranked sixth internationally. This paper examines concentrations of toxic metals and metalloids in the breastmilk of Mayan women in the Lake Atitlán watershed and explores potential relationships with stunting prevalence and demographic parameters to guide future research. We completed a cross-sectional study in 2022 (n = 80 mother/infant dyads) with 20 mother/infant dyads from each of four communities: San Juan La Laguna, San Pedro La Laguna, Panajachel, and Santiago Atitlán. We collected a breastmilk sample from each mother and measured the length of each infant (90–182 days old) to assess stunting (&lt;-2 SD length-for-age below WHO growth standards median), and we collected community drinking water samples. The mean Z-score for stunting was −1.39 (SD = 1.24). Infants from Panajachel had a higher prevalence of stunting (x̅ = −2.06) than did infants from the other three communities. Metals and metalloids were quantified in breastmilk and water samples using inductively coupled plasma - mass spectrometry (ICP-MS). The concentrations of arsenic and lead in breastmilk were above the WHO safety standards in Panajachel and Santiago Atitlán, and concentrations of toxic metal(loid)s overall were highest in Panajachel. For infants from Panajachel and Santiago Atitlán, reduced Z-scores for stunting were associated with higher breastmilk concentrations of arsenic, barium, beryllium, and lead (p = 0.02–0.04). Water samples from these two communities exhibited greater concentrations of arsenic and barium than did water from other communities (p = 0.003–0.03). Significant associations between concentrations of arsenic, barium, beryllium, and lead with stunting score warrant a comprehensive assessment of the potential role of toxic metal(loid)s in child development. Stunting is a complex multifactorial problem; our results indicate that investigations of stunting should also evaluate exposures to toxic metal(loid)s in addition to the traditional causal factors such as malnutrition and chronic infections.</div></div>","PeriodicalId":311,"journal":{"name":"Environmental Pollution","volume":"375 ","pages":"Article 126273"},"PeriodicalIF":7.6,"publicationDate":"2025-04-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143847031","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Soil properties explain the variability in tire wear particle effects in soil based on a laboratory test with 59 soils","authors":"Tingting Zhao, Yaqi Xu, Mohan Bi, Huiying Li, Guanlin Li, Matthias C. Rillig","doi":"10.1016/j.envpol.2025.126271","DOIUrl":"https://doi.org/10.1016/j.envpol.2025.126271","url":null,"abstract":"Tire wear particles (TWPs) are among the most prevalent microplastics in the environment, with potential detrimental effects on ecosystem health and functionality. While little is known how the effects of TWPs on soil physicochemical and microbial properties vary across different soil types, and if so, which factors contribute to this variability. To address this knowledge gap, we conducted a laboratory experiment involving soils from 59 grassland plots across two sampling regions in Germany, each experienced varying land use intensities. These soils were treated with and without TWPs at a concentration of 10 mg g⁻¹. At harvest, we measured soil water-stable aggregates (WSA), pH, respiration, and decomposition rate. Our results revealed that TWPs negatively, neutrally, or positively impacted these parameters depending on soil types. Random forest analysis indicated that the variability in TWP effects was significantly explained by grazing frequency for WSA (14.5%), by clay content for pH (9%), by bulk density for respiration (7.9%), and by silt content for decomposition rate (12%). Partial dependence analysis further suggested that low-intensity grazing (∼ 0.7 to 1.2) reduced TWP effects on WSA; clay content (420 to 550 g kg⁻¹) increased TWP effects on pH; bulk density (0.75 to 0.88) decreased TWP effects, and silt content (460 to 620 g kg⁻¹) enhanced TWP effects on decomposition rate, with the identified thresholds of 1.45, 353 g kg⁻¹, 0.84, and 327 353 g kg⁻¹, respectively. These results highlighted the context-dependent nature of TWP pollution, with significant variability observed across different sampling points. Additionally, our findings suggest that TWP pollution is particularly of concern in soils with high clay, silt, high bulk density, and areas with intensive land-use intensity. Our study contributes to a better understanding of the mechanisms by which TWPs impact soil, and how these effects are regulated by environmental factors.","PeriodicalId":311,"journal":{"name":"Environmental Pollution","volume":"29 1","pages":""},"PeriodicalIF":8.9,"publicationDate":"2025-04-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143846785","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A novel integrated method for ultrasonic-assisted MSWI fly ash decarbonization with PCDD/Fs detoxification and synergistic heavy metals stabilization","authors":"Jie Chen,&nbsp;Congkai Fu,&nbsp;Xiaoqing Lin,&nbsp;Xiaodong Li,&nbsp;Jianhua Yan","doi":"10.1016/j.envpol.2025.126267","DOIUrl":"10.1016/j.envpol.2025.126267","url":null,"abstract":"<div><div>A novel ultrasonic-assisted flotation method was developed to enhance the harmless treatment and resource utilization of municipal solid waste incineration fly ash (MSWI FA). This study examined ultrasound effects on collector (kerosene) and frother (2-octanol) emulsification and its role in flotation decarbonization. Additionally, the mechanism of PCDD/Fs detoxification and heavy metals migration and stabilization were revealed. The results indicated that ultrasonic emulsification significantly improved the collector dispersibility, while optimizing ultrasonic duration and power reduced emulsion droplets size and enhanced the collector adsorption capacity on carbon particles. Under optimal conditions (280 W_10 min), ultrasonic flotation effectively disintegrated agglomerated FA, increased carbon particle exposure, and enhanced decarbonization efficiency to 46.3 %. Meanwhile, ultrasound flotation enhanced NaCl and KCl dissolution, lowering Cl content in residue fly ash (ReFA) to below 2 %. PCDD/Fs were primarily enriched in activated carbon and transferred into the flotation FA (FFA), leading to a 48.9 % reduction in the toxic equivalent of PCDD/Fs in ReFA. Compared to FFA, ReFA exhibited a higher content of high-chlorinated PCDD/Fs, particularly 1,2,3,4,6,7,8-HpCDD, OCDD, 1,2,3,4,6,7,8-HpCDF, and OCDF. This distribution was likely attributed to the different selective adsorption behavior of activated carbon and calcium oxide (CaO). With the addition of 0.5 % Na₂S, the Pb leaching concentration was significantly reduced to 0.01 mg/L. In conclusion, this technology simultaneously achieved dechlorination, decarbonization, PCDD/Fs detoxification, and heavy metal stabilization, offering a low-carbon and energy-efficient FA treatment method.</div></div>","PeriodicalId":311,"journal":{"name":"Environmental Pollution","volume":"374 ","pages":"Article 126267"},"PeriodicalIF":7.6,"publicationDate":"2025-04-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143846784","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Significant effects of earthworm species on antibiotic resistome in livestock manure as revealed by metagenomic analysis","authors":"Ming Yang ,&nbsp;Liang Peng ,&nbsp;Meirui Mu ,&nbsp;Fengxia Yang ,&nbsp;Zhonghan Li ,&nbsp;Bingjun Han ,&nbsp;Keqiang Zhang","doi":"10.1016/j.envpol.2025.126277","DOIUrl":"10.1016/j.envpol.2025.126277","url":null,"abstract":"<div><div>Animal-derived antibiotic resistance genes (ARGs) have emerged as a critical threat, while vermicomposting has been recognized as an effective strategy for reducing ARGs. However, the efficacy of different earthworm species in reducing ARGs remains poorly understood. In this study, 72 vermicompost and earthworm gut samples were collected from various earthworm farms to evaluate the impact of vermicomposting with different earthworm species on ARGs <em>via</em> metagenomic analysis. Approximately 28 ARG types were detected in gut and vermicompost samples. There were significant differences in ARGs among the four species of earthworm composting systems (<em>p</em> &lt; 0.05), and each species possessed its dominant ARGs and microbes. Proteobacteria represented the predominant bacterial phylum within the gut microbiota of <em>Pheretima guillelmi</em> (46.89 %) and <em>Eisenia fetida</em> (48.42 %), whereas Euryarchaeota (36.71 %) and Actinobacteria (39.42 %) were the most abundant in <em>Perionyx excavatus</em> and <em>Eudrilus eugeniae</em>, respectively. The overall abundance of ARGs in vermicompost processed by <em>Eisenia fetida</em> (0.18 copies16S rRNA gene copies) was lower than that observed in other earthworm species (0.23–0.39 copies/16S rRNA gene copies), with gut microbial identified as a key determinant of variations in ARG reduction. These findings provide valuable insights into selecting suitable earthworm species to promote ARG degradation, thus contributing to the decrease in ARG dissemination risks in agricultural ecosystems.</div></div>","PeriodicalId":311,"journal":{"name":"Environmental Pollution","volume":"374 ","pages":"Article 126277"},"PeriodicalIF":7.6,"publicationDate":"2025-04-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143846787","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Tracking antibiotics and antibiotic-resistant E. coli in the aquatic environment linked to agriculture","authors":"Laurens Tuts ,&nbsp;Marc Heyndrickx ,&nbsp;Ilse Becue ,&nbsp;Nico Boon ,&nbsp;Philippe De Maesschalck ,&nbsp;Geertrui Rasschaert","doi":"10.1016/j.envpol.2025.126265","DOIUrl":"10.1016/j.envpol.2025.126265","url":null,"abstract":"<div><div>The application of manure to fertilize agricultural land is associated with the introduction of antibiotic residues and bacteria, including antibiotic-resistant bacteria, which can reach surface water through runoff and drainage and groundwater through leaching from the soil. This was investigated by sampling 50 surface water locations (before and after fertilization) and 50 groundwater wells for the presence of antibiotic residues and the presence of antibiotic-resistant bacteria. For the latter, <em>Escherichia coli</em> and extended-spectrum β-lactamase (ESBL) producing <em>E. coli</em> were used as indicators and profiled for antibiotic resistance. The presence of a wide range of antibiotic residues, though at low concentrations (0.01–10 μg/L), in freshwater ecosystems highlights the extensive spread of these substances. Only 16 % of the samples were consistently free of antibiotic residues throughout both sampling periods. Notably, the frequent occurrence of sulfonamides and lincomycin in surface waters raises concerns as their concentrations occasionally exceed the predicted no-effect levels for antimicrobial resistance selection. Maximum concentrations were reported at 8.83 μg/L and 1.60 μg/L for sulfamethoxazole and lincomycin, respectively. Additionally, resistance patterns in <em>E</em>. <em>coli</em> indicate increased resistance to sulfamethoxazole following the fertilization period, suggesting that the application of manure on fields contributes to a rise in antibiotic resistance from 20 % to 48 %. Although antibiotic contamination in groundwater is less prevalent, antibiotic resistance remains widespread. In particular, ESBL-producing <em>E. coli</em> exhibit heightened resistance levels, not limited to β-lactam antibiotics. The detection of resistance to critical last-resort antibiotics such as carbapenems and colistin further emphasizes the urgency of addressing antibiotic resistance in environmental contexts. This study highlights the need for continued monitoring and the implementation of legislation to reduce antibiotic pollution and tackle resistance in aquatic ecosystems.</div></div>","PeriodicalId":311,"journal":{"name":"Environmental Pollution","volume":"374 ","pages":"Article 126265"},"PeriodicalIF":7.6,"publicationDate":"2025-04-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143846786","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sex- and age-specific mercury contamination in Central Europe's last gull-billed tern population","authors":"Anna Schnelle ,&nbsp;Markus Risch ,&nbsp;Peter J. Schupp ,&nbsp;Miriam Liedvogel ,&nbsp;Sandra Bouwhuis","doi":"10.1016/j.envpol.2025.126264","DOIUrl":"10.1016/j.envpol.2025.126264","url":null,"abstract":"<div><div>Mercury contamination is a growing threat to ecosystems and wildlife due to its adverse effects on animal physiology and its potential to accumulate in long-lived top predators. Endangered species may be especially vulnerable, requiring contamination assessment at both the population- and individual-level. Between 2022 and 2024, we assessed total mercury (THg) contamination in the last population of gull-billed terns (<em>Gelochelidon nilotica</em>) in Central Europe, known to breed in a heavily mercury-polluted area, by collecting blood samples of adults and chicks. Among adults, THg concentrations were variable, but mostly below toxicity thresholds associated with major adverse health effects. They were higher in males than females, and higher when birds were sampled later in the season, but not related to clutch size. Using longitudinally collected data and a within-subject centering statistical approach, females, but not males, were found to accumulate THg as they aged. Chicks exhibited relatively low THg levels, which varied with age (following a bathtub-shape), but not sex. As such, our study suggests sex-specific mercury accumulation in gull-billed terns at levels that are currently associated with low to moderate health effects. We recommend continued monitoring of THg levels and assessing the levels of further contaminants, as well as how they may interact with mercury to affect the birds.</div></div>","PeriodicalId":311,"journal":{"name":"Environmental Pollution","volume":"374 ","pages":"Article 126264"},"PeriodicalIF":7.6,"publicationDate":"2025-04-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143841855","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Associations of exposure to arsenic species and endogenous sex hormones with oral cancer: a hospital-based study in Southeastern China","authors":"Na Wang ,&nbsp;Wenting Zhang ,&nbsp;Haoyuan Song ,&nbsp;Weihai Huang ,&nbsp;Fa Chen ,&nbsp;Fengqiong Liu ,&nbsp;Yulan Lin ,&nbsp;Yu Qiu ,&nbsp;Bin Shi ,&nbsp;Lisong Lin ,&nbsp;Jing Wang ,&nbsp;Baochang He","doi":"10.1016/j.envpol.2025.126259","DOIUrl":"10.1016/j.envpol.2025.126259","url":null,"abstract":"<div><div>The effects of arsenic species and endogenous sex hormones on oral cancer risk, particularly their molecular interactions, have been infrequently reported. This study aimed to assess the individual and combined effects of arsenic species and endogenous sex hormones on oral cancer risk and elucidate the association between hormones, arsenic species, and arsenic metabolism. A case-control study (comprising 144 cases and 144 controls) was conducted from January 2020 to January 2024 in Southeastern China. Serum levels of six arsenic species and nine endogenous sex hormones were measured using High-Performance Liquid Chromatography Inductively Coupled Plasma Mass Spectrometry (HPLC-ICP-MS) and ultra-high performance liquid chromatography-high resolution mass spectrometry (UPLC-HRMS), respectively. After adjusting for potential confounders, Logistic regression showed that high exposure levels of inorganic arsenic (IAs) (adjusted OR [aOR] and 95 %CI: 0.00[0.00,0.44] and 0.45[0.25,0.78]) and Cortisone (aOR and 95 %CI: 0.16[0.07,0.35] and 0.19[0.10,0.37]) were associated with reduced oral cancer risk, both as continuous and categorical variables. Serum Melatonin, Cortisone, and Testosterone levels correlated with partial arsenic species, while Cortisone and Melatonin were linked to arsenic methylation metabolic indexes (spearman's test <em>P</em> &lt; 0.05). Quantile g-computation analysis revealed that Corticosterone and Cortisone had the largest positive and negative weights on oral cancer risk, respectively (weights = 0.640 and 0.525). The combined effect of arsenic species and hormones on oral cancer was protective (β and 95 %CI: 0.36(-0.05,-0.67)), with slight gender differences. Independent of other arsenic species and hormone levels, Cortisone exhibited a protective effect against oral cancer in BKMR analysis. Additionally, an interaction effect between Melatonin and other arsenic species was also observed. In summary, Serum IAs and Cortisone were negatively associated with oral cancer, while Corticosterone showed a positive association. Further cohort studies are needed to confirm and elucidate these mechanisms.</div></div>","PeriodicalId":311,"journal":{"name":"Environmental Pollution","volume":"374 ","pages":"Article 126259"},"PeriodicalIF":7.6,"publicationDate":"2025-04-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143841893","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The effect and mechanisms of nano cerium dioxide (Nano-CeO2) on cardiovascular development in zebrafish (Danio rerio)","authors":"Yiyun Liu ,&nbsp;Yan-Ling Liao ,&nbsp;Jin-Xia Wang,&nbsp;Bao-Fu Zhang,&nbsp;Qi-Ping Tang,&nbsp;Yuan Ding,&nbsp;Si-Jia Zuo,&nbsp;Qin-Hong Zhou,&nbsp;De-Sheng Pei","doi":"10.1016/j.envpol.2025.126268","DOIUrl":"10.1016/j.envpol.2025.126268","url":null,"abstract":"<div><div>The widespread application of nano-cerium dioxide (Nano-CeO₂) in agriculture, industry, and other fields has led to an increasing amount of it being released into the environment and becoming a pollutant with potential biological hazards. However, studies on the effects of ceria on cardiovascular development were limited. This study aims to detect the cardiovascular toxicity of Nano-CeO₂, focusing on its impact on zebrafish hematopoietic function and cardiac development, and to explore its potential molecular mechanisms. We found that exposing zebrafish embryos to different concentrations of Nano-CeO₂ after 6 hpf of fertilization does not hinder the growth and development of zebrafish embryos during their early life stages. However, RNA-Seq analysis indicated that the gene expression related to zebrafish hematopoiesis was significantly downregulated, and the ECM-receptor interaction pathway was disrupted.The results of o-dianisidine staining, neutral red staining, and Sudan black staining showed that the hemoglobin, macrophages, and neutrophils of zebrafish were reduced, and the vascular dysplasia of zebrafish was observed. Meanwhile, Reactive oxygen species (ROS) accumulated in the heart of zebrafish larvae treated with Nano-CeO₂, and heart development-related genes (<em>nppa</em>, <em>hand2</em>, <em>nppb</em>, <em>nkx2.5</em>, and <em>myh7</em>) were significantly down-regulated, while <em>gata4</em> was up-regulated. The addition of the integrin agonist manganese ions restored the expression of genes related to ECM-receptor interaction pathways, alleviating cardiovascular abnormalities caused by Nano-CeO₂. Besides, significant changes in cardiac histopathology were observed with long-term exposure (120 d post-fertilization), indicating that Nano-CeO₂ exposure affected the development of the cardiovascular system in zebrafish. In summary, acute and chronic exposure to Nano-CeO₂ exhibits cardiovascular toxicity in zebrafish, affecting hematopoietic function and cardiac development, and the mechanism may be related to the ECM-receptor interaction pathway. This study provides useful information for a comprehensive understanding of the toxicity mechanisms and environmental risks of Nano-CeO₂.</div></div>","PeriodicalId":311,"journal":{"name":"Environmental Pollution","volume":"374 ","pages":"Article 126268"},"PeriodicalIF":7.6,"publicationDate":"2025-04-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143841856","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}