Chemosphere最新文献

{"title":"Exploring perfluoroalkyl substances contamination in human breast milk: First ghanaian study","authors":"Justice Wiston Amstrong Jonathan ,&nbsp;David K. Essumang ,&nbsp;John K. Bentum ,&nbsp;Daniel Elorm Kwame Kabotso ,&nbsp;Innocentia Ruby Gborgblorvor ,&nbsp;Albert Eshun ,&nbsp;Norkplim Dei Hlorlewu ,&nbsp;Elizabeth Davordzi","doi":"10.1016/j.chemosphere.2024.143769","DOIUrl":"10.1016/j.chemosphere.2024.143769","url":null,"abstract":"<div><div>Perfluoroalkyl and polyfluoroalkyl substances (PFAS) represent a category of synthetic organic chemical contaminants that have garnered increasing attention due to their potential adverse impacts. Existing research underscores the contamination of human breast milk by PFAS, raising concerns regarding potential deleterious health effects in children.</div><div>The study aimed to explore the levels of some PFAS in human breast milk in a previously unstudied population to determine the extent of infants’ exposure.</div><div>The research was conducted at Ho Teaching Hospital in Ghana. The study protocol was reviewed and approval by University of Health and Allied Sciences Ethics Research Committee (UHAS-REC). Twenty-nine (29) mothers, aged 18–44 years, were enrolled in the research. Sample collection spanned from December 28, 2020 to June 30, 2021. Ten millilitres (10 mL) of breast milk were collected from each participant into cleaned bottles from day of birth to after two weeks postpartum, following a standardized protocol and stored at −20 °C. Sample preparation and analysis employed solid phase extraction methodology. Subsequently, the processed extracts were subjected to analysis using ultra-high-performance liquid chromatography (UPLC-MS/MS). The data obtained were analysed using IBM SPSS Statistics version 26, Excel 2016, and Xlstat 2022. Descriptive statistics were employed to summarize the study variables. The mean/mode input method was used to treat missing data. The median and interquartile range (IQR) of PFAS concentrations in the breast milk were: PFHxA, 6.0 ng/L(IQR, 2.2 ng/L), PFHpA, 5.6 ng/L(IQR, 2.1 ng/L), PFOA, 72.0 ng/L(IQR, 16.0 ng/L), and PFOS, 93.0 ng/L(IQR, 8.0 ng/L) ng/L) respectively. PFOS and PFOA were the most dominant PFAS in the breast milk which is consistent with worldwide reports.</div><div>The levels of PFAS, particularly PFOS and PFOA, in breast milk points to seemingly high levels of PFAS exposure and contamination of mothers and neonates in the region.</div></div>","PeriodicalId":276,"journal":{"name":"Chemosphere","volume":"369 ","pages":"Article 143769"},"PeriodicalIF":8.1,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142696126","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sustainable valorization of agricultural waste into bioplastic and its end-of-life recyclability for biochar production: Economic profitability and life cycle assessment","authors":"Robert Senga ,&nbsp;Mahmoud Nasr ,&nbsp;Manabu Fujii ,&nbsp;Amal Abdelhaleem","doi":"10.1016/j.chemosphere.2024.143847","DOIUrl":"10.1016/j.chemosphere.2024.143847","url":null,"abstract":"<div><div>While the industrial sectors have recently focused on producing bioplastic materials, the utilization of edible feedstocks and the generation of wastes and byproducts during the bioplastic synthesis process might delay achieving the environmental sustainability strategy. To overcome these limitations related to bioplastic industrialization, this study focuses on synthesizing bioplastics from waste sources, followed by recycling its end-of-life (e.g., spent and exhausted) material into biochar. Sweet potato peel waste, banana pseudo-stems, and cooking oil waste were used to extract starch, cellulose, and glycerol (a plasticizer) involved in bioplastic manufacturing, respectively. It was found that the cellulose content of 30% w w⁻¹ in bioplastic maintained the best physicochemical, mechanical, and biodegradability properties, recommending a high applicability for food packaging. The exhausted bioplastic was then pyrolyzed to maintain a biochar yield of 32.60 ± 0.89%, avoiding the risk of secondary pollution from waste material disposal. This biochar was utilized to treat wastewater generated from the bioplastic synthesis process, showing the optimum adsorption factors of biochar dosage = 3.81 g L⁻¹, time = 102 min, and solution pH = 7.81. The combined bioplastic production, waste pyrolysis, and wastewater treatment scheme could earn profits from biomaterial sales, carbon credit, and pollution reduction shadow price, maintaining a 6.78-year payback period and a 12.09% internal rate of return. This integrated framework depicted better contributions to the mid-point/end-point life cycle assessment impact categories than the only bioplastic production scenario. This study contributed towards achieving several sustainable development goals (SDGs), including SDG#3: human health protection, SDG#6: wastewater treatment, and SDG#12: waste recycling.</div></div>","PeriodicalId":276,"journal":{"name":"Chemosphere","volume":"369 ","pages":"Article 143847"},"PeriodicalIF":8.1,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142759109","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Substituting phosphorus and nitrogen in hydroponic fertilizers with a waste derived nutrients solution: pH control strategies to increase substitution ratios","authors":"Satoru Sakuma ,&nbsp;Ryosuke Endo ,&nbsp;Toshio Shibuya","doi":"10.1016/j.chemosphere.2024.143805","DOIUrl":"10.1016/j.chemosphere.2024.143805","url":null,"abstract":"<div><div>Hydroponics, despite its potential for efficient crop production, relies heavily on chemical fertilizers derived from nonrenewable resources and thus contributes to environmental burdens and unsustainable use of phosphorus. Integrating hydroponics into a circular phosphorus economy is crucial for mitigating these impacts. This study quantitatively assessed the capacity of filtrates from nitrified biogas digestate (f-NBD), a nutrient solution derived from organic waste, to replace phosphorus and nitrogen in hydroponic chemical nutrient solutions. Additionally, the influence of pH control methods on phosphorus recovery and substitution was investigated using a novel pH-rebound approach involving acidification followed by alkalinization to pH 6. The experimental results demonstrated that the pH-rebound method effectively dissolved apatite phosphorus, the predominant form of precipitated phosphorus in NBD, without inducing significant reprecipitation upon alkalinization. This pH adjustment enhanced the phosphorus solubility and optimized the nitrogen-to-phosphorus (N/P) ratio in f-NBD, enabling it to substitute up to 77% of the phosphorus and 100% of the nitrogen in standard hydroponic nutrient solutions. The study also revealed that, under certain conditions, f-NBD is as a more viable option for phosphorus recovery than struvite, a widely recognized recovered phosphorus product. The identified substitution ratios and pH optimization strategies provide valuable insights for mitigating the environmental burdens of hydroponic fertilizers. By partially replacing chemical nutrient solutions with f-NBD, hydroponics can be integrated more effectively into a circular phosphorus economy, reducing the reliance on nonrenewable resources and curtailing the environmental impacts associated with the production and use of conventional fertilizers. This research provides a basis for future initiatives aimed at developing sustainable hydroponic systems and offering new utilization methods for biogas digestate.</div></div>","PeriodicalId":276,"journal":{"name":"Chemosphere","volume":"369 ","pages":"Article 143805"},"PeriodicalIF":8.1,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142718059","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Machine learning prediction of fundamental sewage sludge biochar properties based on sludge characteristics and pyrolysis conditions","authors":"Yizhan Deng ,&nbsp;Bing Pu ,&nbsp;Xiang Tang ,&nbsp;Xuran Liu ,&nbsp;Xiaofei Tan ,&nbsp;Qi Yang ,&nbsp;Dongbo Wang ,&nbsp;Changzheng Fan ,&nbsp;Xiaoming Li","doi":"10.1016/j.chemosphere.2024.143812","DOIUrl":"10.1016/j.chemosphere.2024.143812","url":null,"abstract":"<div><div>Sewage sludge biochar (SSBC) has significant potential for resource recovery from sewage sludge (SS) and has been widely studied and applied across various fields. However, the variability in SSBC properties, resulting from the diverse nature of SS and its intricate interaction with pyrolysis conditions, presents notable challenges to its practical use. This research employed machine learning techniques to predict fundamental SSBC properties, including elemental content, proximate compositions, surface area, and yield, which are essential for assessing the applicability of SSBC. The models achieved robust predictive accuracy (test R² = 0.82–0.95), except for surface area. Notably, analysis of the optimal models revealed SS characteristics had a significant impact on SSBC properties, particularly total and fixed carbon content (combined importance exceeding 80%). This underscores the needs of source analysis and preparation optimization in targeted SS recovery or SSBC applications. To facilitate this, a graphical user interface was developed for strategic analyzation of sludge sources and pyrolysis settings.</div></div>","PeriodicalId":276,"journal":{"name":"Chemosphere","volume":"369 ","pages":"Article 143812"},"PeriodicalIF":8.1,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142741610","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Toxic effects of acute and chronic atorvastatin exposure on antioxidant systems, autophagy processes, energy metabolism and life history in Daphnia magna","authors":"Yimeng Wang ,&nbsp;Yingshi Hou ,&nbsp;Cuiping He ,&nbsp;Yufei Zhao ,&nbsp;Chunni Duan ,&nbsp;Xiangping Nie ,&nbsp;Jianjun Li","doi":"10.1016/j.chemosphere.2024.143792","DOIUrl":"10.1016/j.chemosphere.2024.143792","url":null,"abstract":"<div><div>Atorvastatin (ATV) is a representative for hypolipidemic pharmaceuticals and is widely detectable in aquatic environments around the world. However, there are limited studies on the potential effects of ATV on aquatic non-target organisms, especially on aquatic invertebrates. In the present study, the model organism, <em>Daphnia magna</em> was used to investigate the responses of antioxidant system, autophagy process and energy metabolism under the acute exposure of ATV (24 h–96 h), and the changes of physiological parameters of <em>D. magna</em> in response to chronic ATV exposure (21 d) was addressed as well. The results showed that ATV caused oxidative stress in <em>D. magna</em> and elevated activities of antioxidant enzymes (SOD, GST, GPx, and TrxR) at 48 h. However, the progressively increasing oxidative pressure eventually suppressed antioxidant capacities and triggered the transcriptional autophagy process in organism under the regulation of <em>Sestrin</em> as well as its regulated genes (<em>P62</em>, <em>LC3</em>, <em>ATG1</em>, and <em>ATG4B</em>). ATV also altered the expression of DNA methylation related genes. Unlike the clinical response, we found acute ATV exposure led to lipid accumulation in <em>D. magna</em>, affecting energy metabolism. Chronic exposure of higher concentration of ATV (50, 500 μg L⁻¹) adversely affected growth and reproduction parameters of <em>D. magna</em>, caused delayed molting, reduced body length, and decreased number and delayed time of neonates production. Lethal effects were observed in the 5000 μg L⁻¹ of ATV. The present study investigated the toxic effects and mechanisms of acute and chronic ATV exposure on <em>D. magna</em> to provide a scientific basis for evaluating the potential ecological risks of statins on aquatic invertebrates.</div></div>","PeriodicalId":276,"journal":{"name":"Chemosphere","volume":"369 ","pages":"Article 143792"},"PeriodicalIF":8.1,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142693998","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Molecular composition and formation mechanism of chlorinated organic compounds in biological waste leachate treated by electrochemical oxidation with a boron-doped diamond anode","authors":"Feiyan Fang,&nbsp;Qibin Li","doi":"10.1016/j.chemosphere.2024.143788","DOIUrl":"10.1016/j.chemosphere.2024.143788","url":null,"abstract":"<div><div>The use of electrochemical oxidation with boron-doped diamond (BDD) as an anode has been demonstrated to be an effective means of removing dissolved organic matter (DOM) from biologically treated waste leachate. However, in the presence of chloride ions, undesired chlorine evolution occurs on the anode; this forms chlorinated DOM, mostly of unknown molecular composition. We investigate the molecular composition and formation mechanism of chlorinated DOM during electrochemical oxidation process of biologically treated leachate DOM. At a current density of 8 mA/cm², after 120 min of electrolysis, 479 unknown chlorinated DOMs were detected in the treated effluent, comprising 21.55% of the total. The unknown species are dominated by oxygen-rich, highly unsaturated structures, and exhibit higher oxidation degrees, lower unsaturation, and lower aromaticity compared to the removed nonchlorinated DOM. An additional 43.63 mg/L of known chlorinated DOM species, predominantly dichloroacetic and trichloroacetic acids, also accumulate in the treated effluent. Introducing hydroxyl radicals (HO^•) to the anode surface forms reactive chlorine species including chlorine radical (Cl^•), dichlorine radical (Cl₂^•−), and hypochlorous acid/hypochlorite (HOCl/OCl⁻); the concentration of HOCl/OCl⁻ reaches 529.2 mg/L. These species react with reduced and aromatic dissolved organic matter via reaction pathways such as chlorine substitution for hydrogen (Cl₊H_-) and the HOCl addition reaction (HO₊Cl₊) to generate unknown chlorinated DOM species; the known chlorinated DOM are formed afterward via ring opening and dealkylation pathways. Our results provide a theory for the prevention and control of chlorinated DOM during treatment of chlorine-laden organic wastewater by an electrochemical oxidation system with a boron-doped diamond anode.</div></div>","PeriodicalId":276,"journal":{"name":"Chemosphere","volume":"369 ","pages":"Article 143788"},"PeriodicalIF":8.1,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142694039","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Antibiotics residues in inland and transitional sediments","authors":"Martin Sharkey ,&nbsp;William A. Stubbings ,&nbsp;Stuart Harrad ,&nbsp;Mark G. Healy ,&nbsp;Shijie Wang ,&nbsp;Jingxi Jin ,&nbsp;Ann Marie Coggins","doi":"10.1016/j.chemosphere.2024.143793","DOIUrl":"10.1016/j.chemosphere.2024.143793","url":null,"abstract":"<div><div>This study assesses the concentrations of a range of antibiotics in riverine and transitional sediments in Ireland. A selection of 12 macrolide, fluoroquinolone, sulphonamide, and diaminopyrimidine antibiotics were quantified in 80 grab surficial sediment samples from around Ireland, selected to investigate areas of potentially higher pollution risk (agriculture, aquaculture, industrial emissions, and wastewater emission points) as well as isolated areas where there are no known pollution sources. Several of the macrolides and sulphonamides/trimethoprim were generally detected more frequently above limits of quantification (LoQ). Fluoroquinolones, while frequently detected above limits of detection (LoD), concentrations were mostly below method LOQs. The most prevalent antibiotic detected was clarithromycin, found at the highest mean concentration (6.65 ng/g) and detected in ∼90 % of samples. Comparing levels of quantified antibiotics to levels reported internationally, Ireland is at the lower end for all quantified antibiotics. This is with the notable exception of clarithromycin, which is higher than levels found in comparable studies in Italy, Spain, France, and Argentina. Higher levels of total antibiotics (49.3 ± 24.7 ng/g) were found to be present immediately adjacent to wastewater emission points while moderate degrees of contamination (9.0 ± 9.7 ng/g) were also linked to wastewater, aquaculture, or agricultural pressures. Based on risk quotients calculated from available sediment PNECs taken from the NORMAN ecotoxicology database, clarithromycin was also the only compound to be present at concentrations indicative of a “moderate” degree of environmental risk, with most of the remaining falling below this threshold. Ciprofloxacin was ostensibly found to be of a “high” degree of environmental risk; however, this is based on only a single sample quantified above the LoQ. Overall, antibiotic sediment concentrations suggest a low ecotoxicological risk for most of the target antibiotics, although clarithromycin, ciprofloxacin, and sulfamethoxazole warrant further monitoring in sediments. A final notable finding is the differences in partitioning behaviour of antibiotics between water and sediment: clarithromycin is more likely to be detected in sediment while sulfamethoxazole partitions more to water. Such partitioning behaviour should therefore be taken into consideration for any subsequent monitoring programmes.</div></div>","PeriodicalId":276,"journal":{"name":"Chemosphere","volume":"369 ","pages":"Article 143793"},"PeriodicalIF":8.1,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142696097","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Bystander dermal exposure to drift during pesticide application in vineyards: An experimental factorial study","authors":"Sonia Grimbuhler ,&nbsp;Jean-François Viel","doi":"10.1016/j.chemosphere.2024.143809","DOIUrl":"10.1016/j.chemosphere.2024.143809","url":null,"abstract":"<div><div>Although public concerns about their exposure to agricultural pesticides and the potential impacts on their health began to gain momentum around the early 2000s, there is limited data on the direct exposure of bystanders to spray drift through the deposition of drift droplets on the skin. To address these knowledge gaps in vineyards, trials were conducted on a test bench using artificial vegetation and wind. Different spraying technologies and drift mitigation measures, such as air-induction nozzles or hedgerows along the vineyard margin, were compared. Sulforhodamine B was used as a fluorescent tracer to mimic pesticide contamination under real-use conditions. In total 72 t-shirts on manikins were used, resulting in 144 cotton collectors (arms and torsos) for extracting the tracer. The dermal exposure levels were expressed in μL spray and compared using nonparametric ANOVA analyses in a factorial experimental framework. All the factor and interaction terms had a highly significant effect (p &lt; 10⁻⁶) on the exposure level. There was an exponential-like decay in the average exposure with distance (3.3, 5, 10 and 20 m, respectively). In terms of sprayers, a noticeable trend was observed with drift reduction technology. The presence of a hedgerow had a substantial effect, flattening the exposure curves with distance, regardless of the sprayer. This study produced realistic bystander exposure levels for different combinations involving the presence of a hedgerow, distances and drift reduction devices. Before entering these data into refined risk assessment models for grapevine production, hedgerows should be characterized more thoroughly, while accounting for potential secondary drift.</div></div>","PeriodicalId":276,"journal":{"name":"Chemosphere","volume":"369 ","pages":"Article 143809"},"PeriodicalIF":8.1,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142741554","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Unveiling a novel mechanism: Reduction of graphene oxide by Lysinibacillus sp. through secretion of l-ascorbic acid","authors":"Yuanyuan Zhou ,&nbsp;Ziyi Lin ,&nbsp;Yonghe Han ,&nbsp;Li Gan ,&nbsp;Ying Cheng ,&nbsp;Zuliang Chen","doi":"10.1016/j.chemosphere.2024.143813","DOIUrl":"10.1016/j.chemosphere.2024.143813","url":null,"abstract":"<div><div>The graphene oxide (GO) reduction by microorganisms has garnered considerable interest, yet the specific mechanisms underlying the bacteria secretion of reducing substances for GO reduction remain unclear. This study aims to learn that bacterial extracellular components can reduce graphene oxide through direct (contacting GO) and indirect (not contacting GO) reduction experiments. The subsequent investigation focused on identifying the specific substances secreted by bacteria capable of GO reduction. The results of non-targeted metabolomics revealed differential expression of cacid (L-AA) demonstrates a significant up-regulation. The further experiment involved the supplementation of L-AA in the reduction system of <em>Lysinibacillus</em> sp. with GO, demonstrating enhanced reduction efficacy, with the I_D/I_G ratio of reduced graphene oxide (rGO) increasing to 1.073 after 4 d of reduction with 0.5 g L⁻¹ L-AA. Therefore, the mediation of GO reduction by L-AA secreted by <em>Lysinibacillus</em> sp. is proposed as a viable mechanism, offering novel insights into microbial GO reduction.</div></div>","PeriodicalId":276,"journal":{"name":"Chemosphere","volume":"369 ","pages":"Article 143813"},"PeriodicalIF":8.1,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142741568","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Antimicrobial resistance genes and associated mobile genetic elements in Escherichia coli from human, animal and environment","authors":"Chanchal Rana ,&nbsp;Vaibhav Vikas ,&nbsp;Saraswati Awasthi ,&nbsp;Devika Gautam ,&nbsp;Ashutosh Vats ,&nbsp;Shiveeli Rajput ,&nbsp;Manisha Behera ,&nbsp;Ashutosh Ludri ,&nbsp;Anupam Berwal ,&nbsp;Dheer Singh ,&nbsp;Sachinandan De","doi":"10.1016/j.chemosphere.2024.143808","DOIUrl":"10.1016/j.chemosphere.2024.143808","url":null,"abstract":"<div><div>The global rise of antimicrobial resistance (AMR) poses a significant threat to human health. The environment plays an essential role in transmission of antimicrobial resistance genes (ARGs) between human and animal. Bacterial communities harbour diverse ARGs, carried by mobile genetic elements (MGEs) like plasmids and insertion sequences (ISs). Here, a total of 2199 <em>Escherichia coli</em> (<em>E. coli</em>) whole genome sequences from human, animal, bird and environment were retrieved globally to investigate ARG prevalence and assess their genetic framework. The study highlights how the genetic background including plasmids, IS elements and transposons surrounding ARGs influences their transmission potential. The maximum number of ARGs was found in United Kingdom followed by USA, majorly in human hosts. However, IS-associated ARGs were most prevalent in bird hosts. ARGs like <em>aph</em>(6)-ld<em>, aph</em>(3″)-lb<em>, bla</em>_CTX-M<em>, bla</em>_NDM were widespread across all hosts. Tn<em>2</em> was the most prevalent, majorly carried by IncFIB plasmids. The IS<em>26</em> and IS<em>Vsa3</em> carried diverse ARGs, primarily linked to aminoglycoside and β-lactam resistance. The combinations like <em>mph(A)</em>_IS<em>6100</em> and <em>bla</em>_NDM-5<em>_</em>IS<em>5</em> showed fixed IS-ARG associations. ARGs like <em>bla</em>_NDM<em>, bla</em>_CTX-M variants displayed strong association with IS elements. The study highlights possible mechanism of transmission due to close proximity of AMR genes to MGEs, offering promising strategies to combat AMR by predicting and addressing future resistance determinants.</div></div>","PeriodicalId":276,"journal":{"name":"Chemosphere","volume":"369 ","pages":"Article 143808"},"PeriodicalIF":8.1,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142743094","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}