Chemosphere最新文献

{"title":"BiFeO3/graphitic-carbon/PVDF composite with an electrical percolation network to enhance ciprofloxacin removal by photoelectrocatalytic ozonation","authors":"R.L. Palomino-Resendiz ,&nbsp;A.B. Piña-Guzmán ,&nbsp;A.E. Yañez-Rios ,&nbsp;F.S. Sosa-Rodríguez ,&nbsp;R.M. Luna-Sanchez ,&nbsp;I.C. Romero-Ibarra ,&nbsp;L. Lartundo- Rojas ,&nbsp;J. Vazquez-Arenas","doi":"10.1016/j.chemosphere.2025.144811","DOIUrl":"10.1016/j.chemosphere.2025.144811","url":null,"abstract":"<div><div>Ternary BiFeO₃ (BFO)/Graphitic-Carbon/polyvinylidene fluoride (PVDF) composite photoanodes are fabricated at different compositions: 76:12:12, 80:10:10, and 90:5:5 wt% to account their influence during the degradation of 20 mg L⁻¹ ciprofloxacin (CIP, C₁₇H₁₈N₃FO₃) in synthetic water, using photoelectrocatalytic ozonation (PECO). BFO acts as active phase, Graphitic-Carbon as electronic conductor, and PVDF as binder. The crystalline structure of BFO synthesized by a high–energy ball milling method is confirmed by X-ray diffraction (XRD), Rietveld Refinement and Raman analysis; while Scanning Electronic Microscopy (SEM) images reveal an adequate dispersion on the substrate of all components for the 80:10:10 wt % composition, which differ in other composite ratios. Cross-sectional SEM imaging are also collected for the composites. XPS analysis confirms the presence of Bi³⁺ and Fe³⁺ species associated with the BFO phase. Optoelectronic and electrochemical characterizations conducted for all composites reveal that the 80:10:10 wt % composite generates a remarkable enhancement of 90 % CIP degradation after 60 min (Total Organic Carbon removal = 74.83 %) of treatment, according to high-performance liquid chromatography (HPLC) measurements. This was achieved due to the effective charge carriers separation (e⁻ and h⁺) in the BFO photoanode which is an n-type semiconductor, whence it requires the establishment of an interconnected network with a good electronic conductor like graphite expediting the charge transport to the cathode, and a binder to provide mechanical integrity to the entire composite. This is explained in terms of a photoelectrocatalytic mechanism rationalizing the electrical percolation network in the composites. The reaction mechanism of the CIP abatement is discussed along with the oxidants responsible for its elimination, detected by trapping tests with different scavengers. Toxicity bioassays conducted with <em>Daphnia magna</em> confirm that the water treated with the synergic PECO method is not toxic. Additionally, no physical, cardiac effects or alterations are observed in the swimming behavior of these organisms.</div></div>","PeriodicalId":276,"journal":{"name":"Chemosphere","volume":"394 ","pages":"Article 144811"},"PeriodicalIF":8.1,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145880337","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of chloromethylisothiazolinone/methylisothiazolinone on cytotoxicity and mitochondrial dysfunction in bronchial epithelial cells","authors":"Eunah Lee ,&nbsp;Haeun Lee ,&nbsp;Yong Joo Park ,&nbsp;Kyu Hyuck Chung ,&nbsp;Hyung Sik Kim","doi":"10.1016/j.chemosphere.2026.144831","DOIUrl":"10.1016/j.chemosphere.2026.144831","url":null,"abstract":"<div><div>A mixture of 5-chloro-2-methyl-4-isothiazolin-3-one (CMIT) and 2-methyl-4-isothiazolin-3-one (MIT) is frequently utilized as a biocide in various personal care products (PCP). However, toxicity attributed to this mixture remains poorly understood. Therefore, this study aimed to investigate effects of CMIT/MIT on the respiratory system using human bronchial epithelial BEAS-2B cells as a model. In this study, the mechanisms underlying CMIT/MIT-induced toxicity were examined with particular focus on mitochondria-mediated apoptotic and autophagy cell death using BEAS-2B cells. Notably, CMIT-MIT initiated cytotoxic effects on BEAS-2B cell viability at concentrations of 10 μg/mL following 1 h treatment. In addition, CMIT-MIT treatment inhibited complex II in a concentration-dependent manner, diminished mitochondrial membrane potential and altered dynamic balance between mitochondrial fission and fusion indicative of mitochondrial damage. Further, exposure to 10 μg/mL CMIT-MIT for 1 h induced cellular damage, elevated mitochondrial reactive oxygen species (ROS) levels and concomitantly increased levels of apoptosis and autophagy. Taken together our findings indicate the potential of CMIT/MIT exposure to disrupt mitochondrial functions, thereby initiating apoptotic and autophagic processes in human bronchial epithelial BEAS-2B cells.</div></div>","PeriodicalId":276,"journal":{"name":"Chemosphere","volume":"395 ","pages":"Article 144831"},"PeriodicalIF":8.1,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145999481","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of ions co-occurring in water on antibiotics degradation by UV-based advanced oxidation process","authors":"Zaied Bin Khalid ,&nbsp;Celine Kelso ,&nbsp;Jason van de Merwe ,&nbsp;Faisal I. Hai","doi":"10.1016/j.chemosphere.2025.144798","DOIUrl":"10.1016/j.chemosphere.2025.144798","url":null,"abstract":"<div><div>The pollution of natural water sources with antibiotics is an emerging environmental concern. This study evaluated the degradation efficiency of nine antibiotics in a mixed solution under different UV-based advanced oxidation processes. In the UV-only treatment, ciprofloxacin, cefalexin, and ceftiofur were fully degraded within 5 min, meropenem within 10 min, and penicillin G, roxithromycin, oxytetracycline, doxycycline, and sulfamethazine within 30 min. The effects of inorganic ions and organic matter were investigated due to their significant influence on the degradation performance of antibiotics. Chloride ion, sulfate ion, and humic acid negatively affected degradation, reducing mean degradation efficiency over a period of 15 min to 60–80 %, 57–97 %, and 74–79 %, respectively. In contrast, nitrate, phosphate, and bicarbonate enhanced degradation, with mean degradation efficiency exceeding 95 %. To further enhance the degradation efficiency, UV-based oxidants (persulfate, peroxide, and chlorine) were applied, achieving 95–100 % degradation within 15 min, except for roxithromycin, which required a longer incubation period for complete degradation. A bioluminescence assay showed relatively low acute toxicity of the antibiotics before and after treatments, with a maximum of 4.1 rTU observed during the UV/chlorine process in the presence of co-occurring ions. Notably, this is the first study to report on antibiotic degradation under realistic concentrations of antibiotics and co-occurring ions, demonstrating that the UV/chlorine process offers the most effective performance for antibiotic degradation.</div></div>","PeriodicalId":276,"journal":{"name":"Chemosphere","volume":"394 ","pages":"Article 144798"},"PeriodicalIF":8.1,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145783822","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Selective anticancer activity of doped zinc ferrite nanoparticles: A comparative study on human breast (MCF-7) and lung (A549) cancer cells","authors":"B. Jyothish ,&nbsp;John Jacob","doi":"10.1016/j.chemosphere.2026.144826","DOIUrl":"10.1016/j.chemosphere.2026.144826","url":null,"abstract":"<div><div>This study systematically investigates the anticancer potential of zinc ferrite (ZnFe₂O₄) nanoparticles doped with aluminium (AZF), nickel (NZF), cobalt (CZF), and silver (SZF), with the goal of identifying the most effective formulation for cancer therapy. Based on the selective index and cytotoxicity screening across A549 (lung), MCF-7 (breast), and L929 (normal fibroblast) cell lines, silver-doped zinc ferrite (SZF) emerged as the optimal candidate. SZF exhibited the lowest LC₅₀ values in A549 (7.17 μg/mL) and MCF-7 (41.30 μg/mL) cells while maintaining comparatively higher LC₅₀ in L929 cells (172.90 μg/mL), indicating favorable cancer-selective cytotoxicity. Physicochemical characterization using XRD, FE-SEM, UV–Vis spectroscopy, and Williamson–Hall analysis confirmed phase purity, nanoscale crystallite size (7.6 nm for SZF), and minor dopant-induced structural perturbations. Biological evaluations demonstrated that SZF induced marked oxidative stress<strong>,</strong> with ROS levels increasing 3.4-fold in A549 and 12.4-fold in MCF-7 cells. This oxidative burden was associated with significant alterations in antioxidant enzyme activity, including catalase suppression in A549 cells and catalase elevation in MCF-7 cells. Flow cytometry revealed cell-cycle arrest<strong>,</strong> predominantly at the G0/G1 phase in A549 cells and G2/M arrest in MCF-7 cells, indicating cell-line-specific checkpoint responses. Annexin-V assays confirmed apoptosis as the primary mode of cell death. Furthermore, wound-healing assays demonstrated that SZF significantly inhibited cell migration in both cancer cell lines, suggesting potential anti-metastatic activity. Collectively, the results identify SZF nanoparticles as a promising multifunctional anticancer agent that exerts selective cytotoxicity through ROS generation, cell-cycle arrest, apoptosis induction, and migration inhibition.</div></div>","PeriodicalId":276,"journal":{"name":"Chemosphere","volume":"395 ","pages":"Article 144826"},"PeriodicalIF":8.1,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145923907","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of indigenous soil microbes on switchgrass tolerance to lead stress","authors":"Wei Ren ,&nbsp;Gail W.T. Wilson ,&nbsp;Yipeng Zhang ,&nbsp;Frost Trussell ,&nbsp;Tingying Xu","doi":"10.1016/j.chemosphere.2025.144797","DOIUrl":"10.1016/j.chemosphere.2025.144797","url":null,"abstract":"<div><div>Lead (Pb) contamination of soil poses a significant and pressing environmental threat to a multitude of ecosystems. Phytoremediation assisted by the collaborative activities of rhizosphere soil microbes holds considerable promise for the removal of metal contaminants from affected sites. Nevertheless, there remains a substantial shortage of knowledge regarding the impact of indigenous rhizosphere soil microbes on plant strategies for Pb accumulation and Pb speciation within plant-microbial root associations. In this study, switchgrass (<em>Panicum virgatum</em>) was grown in soils with varied Pb stress (0, 200, 800, 1400, and 2000 mg/kg), with and without native microbial inoculants, to investigate how plant–microbe interactions influence Pb transfer and speciation in native soils. Notably, our findings highlight the remarkable Pb tolerance of switchgrass. The plants sustained robust growth and resilience even at 2000 mg/kg, a concentration far exceeding the recommended Pb limit for human health. Native microbial inoculation significantly increased Pb retention in roots and reduced its translocation to leaves, likely due to a stable symbiosis with arbuscular mycorrhizal (AM) fungi. The combination of switchgrass and microbial inoculants altered soil pH and rhizosphere processes, consequently leading to changes in the bioavailability of Pb. A numerical model based on the mass balance equation predicted that over 80 % of bioavailable soil Pb could be removed within 120 days. Our study advances the understanding of Pb accumulation and transfer in plants and the benefits of inoculation with indigenous soil microbial communities, thereby laying the foundation for the development of enhanced phytoremediation strategies of efficient Pb removal from contaminated soils.</div></div>","PeriodicalId":276,"journal":{"name":"Chemosphere","volume":"394 ","pages":"Article 144797"},"PeriodicalIF":8.1,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145746005","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Perfluorooctane sulfonic acid (PFOS) perturbs skeletal muscle oxidative phosphorylation by a different mechanism than liver","authors":"Jazmine A. Eccles-Miller ,&nbsp;Lanie A. Williams ,&nbsp;Elizabeth Leonard ,&nbsp;Nishanth Tharayil ,&nbsp;Elliet L. Buslee ,&nbsp;Joanna Fiddler ,&nbsp;William S. Baldwin","doi":"10.1016/j.chemosphere.2025.144815","DOIUrl":"10.1016/j.chemosphere.2025.144815","url":null,"abstract":"<div><div>PFOS perturbs normal energy metabolism such as lipid metabolism; however, despite being a highly metabolic organ, skeletal muscle toxicity has not been widely studied. Skeletal muscle, a healthy body's largest metabolic organ, presents a target for PFOS-induced metabolic toxicity due to its high mitochondrial content. Therefore, we aimed to evaluate the response of skeletal muscle to PFOS in vivo and compare the responses to liver. Mice were treated with 0, 1, or 10 mg/kg/day PFOS for 21-days and gastrocnemius and liver collected. All mice exhibited a dose-dependent decrease in bodyweight following PFOS treatment; only females were susceptible to loss of muscle mass. In contrast, liver weight increased in all mice. PFOS showed significant bioaccumulation in gastrocnemius, albeit lower than the liver. Despite reduced bioaccumulation, gastrocnemius was highly sensitive to transcriptomic changes. Only 5 % of differentially expressed genes were shared between the tissues. In gastrocnemius, mitochondrial OXPHOS pathways were highly sensitive to PFOS with ETC 1 most sensitive based on GO term and KEGG pathway analysis. In liver, PPAR transcription and fatty acid metabolism were some of the more sensitive pathways. Mitochondrial respiration assays (Seahorse) confirmed that complex I and IV capacity in PFOS-treated female gastrocnemius was repressed, whereas complex II capacity was repressed by PFOS treatment in liver. An increase in fast-oxidative fibers may have provided males, in comparison to females, some compensatory protection from the effects of PFOS. These results indicate that skeletal muscle is sensitive to PFOS toxicity, and PFOS perturbs different pathways in skeletal muscle than liver.</div></div>","PeriodicalId":276,"journal":{"name":"Chemosphere","volume":"394 ","pages":"Article 144815"},"PeriodicalIF":8.1,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145879547","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Environmental tobacco smoke is a major contributor to lead, cadmium, and arsenic in settled house dust","authors":"Nicolas Lopez-Galvez ,&nbsp;E. Melinda Mahabee-Gittens ,&nbsp;Penelope J.E. Quintana ,&nbsp;Ashley L. Merianos ,&nbsp;Nathan G. Dodder ,&nbsp;Eunha Hoh ,&nbsp;Lara Stone ,&nbsp;Kayo Watanabe ,&nbsp;Georg E. Matt","doi":"10.1016/j.chemosphere.2025.144820","DOIUrl":"10.1016/j.chemosphere.2025.144820","url":null,"abstract":"<div><div>Tobacco smoke contains toxic chemicals, including heavy metals lead (Pb), cadmium (Cd), and arsenic (As), that are found in secondhand and thirdhand smoke, the chemical residue that lingers and accumulates in indoor environments. This study examined tobacco smoke's contribution to heavy metal accumulation in house dust after smoking stops. Dust samples were collected from 179 homes of cigarette smokers with young children and analyzed for nicotine and tobacco-specific nitrosamines (TSNAs) using isotope-dilution liquid chromatography-tandem mass spectrometry. Pb, Cd, and As were analyzed by inductively coupled plasma-mass spectrometry. Bivariate correlation and multivariable models were used to examine associations between tobacco use markers and heavy metal dust loading, controlling for sociodemographic, home, and smoking characteristics. All samples contained Pb (geometric mean: 34.2 μg/m²), Cd (0.40 μg/m²), As (1.6 μg/m²), nicotine (15.7 μg/m²), and TSNAs (6.0 ng/m²); 100 % exceeded the current EPA standard for Pb (0 μg/ft²). Metals correlated positively with nicotine (Pb: r = 0.68; Cd: r = 0.70; As: r = 0.70; all p &lt; 0.001) and TSNAs (Pb: r = 0.50; Cd: r = 0.47; As: r = 0.51; all p &lt; 0.001). Nicotine loading was strongly associated with higher loading of the other contaminants (Pb: <span><math><mrow><mover><mi>β</mi><mo>ˆ</mo></mover></mrow></math></span> = 0.68; Cd: <span><math><mrow><mover><mi>β</mi><mo>ˆ</mo></mover></mrow></math></span> = 0.71; As: <span><math><mrow><mover><mi>β</mi><mo>ˆ</mo></mover></mrow></math></span> = 0.69; TSNAs: <span><math><mrow><mover><mi>β</mi><mo>ˆ</mo></mover></mrow></math></span> = 0.83; all p &lt; 0.001). The semi-partial R² values showed that nicotine uniquely explained 43 % of Pb, 58 % of Cd, and 54 % of As dust-loading variance. Our model projected that, in a fully tobacco-free home, dust loadings of Pb, Cd, and As would decrease by 87 %, 49 %, and 38 %, respectively. This study provides compelling evidence that tobacco smoke residue is a significant yet underrecognized source of toxic metals in household dust, independent of established factors such as housing age. It substantially contributes to indoor lead, cadmium, and arsenic levels. Given children's heightened vulnerability, these findings highlight the urgency of smoke-free policies and thirdhand smoke remediation.</div></div>","PeriodicalId":276,"journal":{"name":"Chemosphere","volume":"394 ","pages":"Article 144820"},"PeriodicalIF":8.1,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145880339","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Treatment and valorization of spent caustic brine: A critical review with emphasis on membrane technologies","authors":"Rouba D. Al Bostami ,&nbsp;Amani Al Othman ,&nbsp;Muhammad Tawalbeh ,&nbsp;Kerry N. McPhedran ,&nbsp;Mohammad Mahdi A. Shirazi","doi":"10.1016/j.chemosphere.2026.144835","DOIUrl":"10.1016/j.chemosphere.2026.144835","url":null,"abstract":"<div><div>Spent caustic brine (SCB) is a hazardous yet resource-rich industrial waste, primarily composed of sodium hydroxide, water, and contaminants such as sulfides, phenols, organic compounds, heavy metals, and valuable minerals. Originating from industries such as oil and gas, metal finishing, and food processing, SCB poses high pH (&gt;11), high total dissolved solids (up to 58,000 ppm), heavy metal content, and elevated chemical oxygen demand (COD). In this work, treatment and valorization methods for SCB are categorized into three groups: traditional techniques without caustic or water recovery, conventional techniques with limited recovery, and membrane technologies offering effective caustic and water recovery (85 % and 90 %, respectively). This review emphasizes membrane technologies due to their potential for resource recovery and environmental sustainability. Traditional and conventional methods are also discussed to provide a comprehensive overview. Unlike approaches that focus solely on treatment, this work critically examines valorization strategies that align with circular economy principles, aiming to recover valuable resources rather than dispose of them. The novelty of this study lies in its shift from waste treatment to resource and water recovery, promoting sustainable management practices. Future research should focus on advancing membrane technologies and integrating valorization pathways to minimize environmental impact and maximize economic benefits.</div></div>","PeriodicalId":276,"journal":{"name":"Chemosphere","volume":"395 ","pages":"Article 144835"},"PeriodicalIF":8.1,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145999849","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Rare earth element abundances and gadolinium contamination in tap water worldwide","authors":"Jean-Alix Barrat ,&nbsp;Germain Bayon ,&nbsp;Raphaël Tripier ,&nbsp;Marie-Laure Rouget ,&nbsp;Yoan Germain ,&nbsp;Douraied Ben Salem","doi":"10.1016/j.chemosphere.2025.144812","DOIUrl":"10.1016/j.chemosphere.2025.144812","url":null,"abstract":"<div><div>Gadolinium-based contrast agents (GBCAs) are widely used in magnetic resonance imaging (MRI) and have emerged as persistent contaminants in surface and drinking water since the 1990s. We present a method based on the coprecipitation of rare earth elements (REEs) with iron hydroxides to estimate the amount of macrocyclic GBCAs in water, and apply it here for the first time to investigate the degree of Gd contamination in tap water worldwide. Our results indicate that Gd contamination is widespread in drinking water distribution systems. Tap water in big European cities such as Berlin, Amsterdam, Paris, and Lyon is more contaminated in Gd than tap water from Asian (Beijing, Guangzhou, Wuhan, Shanghai, Seoul, Tokyo) or American megacities (Los Angeles, New York, and Rio de Janeiro). Furthermore, our data suggest that drinking water treatment processes degrade Gd complexes to varying extent, which can increase the bioavailability of free Gd ions.</div></div>","PeriodicalId":276,"journal":{"name":"Chemosphere","volume":"394 ","pages":"Article 144812"},"PeriodicalIF":8.1,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145797459","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Keto-enol insecticides disrupt ovarian Wnt/armadillo signaling and redox balance, inducing generational toxicity in Drosophila melanogaster","authors":"Berenyce González Marín ,&nbsp;José Pedraza-Chaverri ,&nbsp;Omar Noel Medina-Campos ,&nbsp;Edmundo Bonilla ,&nbsp;Hilda Zamira Vilchis González ,&nbsp;Mauricio Reyes Acuña ,&nbsp;María Elena Calderón-Segura","doi":"10.1016/j.chemosphere.2025.144816","DOIUrl":"10.1016/j.chemosphere.2025.144816","url":null,"abstract":"<div><div>This study is the first to detect Wnt/armadillo signaling pathway activity in the germarium of Fz3-RFP transgenic <em>Drosophila melanogaster</em> females orally exposure to sublethal concentrations of the keto-enol insecticides Movento® 240 SC (0, 11.2, 22.4, 37.3 mg/L) and Envidor® 240 SC (0, 12.3, 24.6, 41.1 mg/L) for 72 h. Both insecticides induced irregular overexpression of receptor Fz3 in regions 1 and 2a of the germarium, accompanied by morphological changes, tissue disorganization, and reduced cell number compared to controls. In wild-type females, oxidative stress was evidenced by increased MDA (malondialdehyde) levels and elevated antioxidant enzyme activities of SOD (superoxide dismutase) and CAT (catalase) following exposure. These effects correlated with reduced fertility, reproduction, and generational alterations, assessed via oviposition and hatching rates, and larval development (L1, L2, L3). Movento® 240 SC and Envidor® 240 SC significantly increased MDA (0.32–0.78 and 0.21–0.57 nmol mg⁻¹ protein) and enzymatic activities of CAT (0.16–0.20 and 0.13–0.15 U mg⁻¹ protein) and SOD (0.40–0.69 and 0.19–0.54 U mg⁻¹ protein), respectively, compared to controls. Oviposition and hatching rates decreased to 22–62 % and 47–86 %. Larval progression from L1 to L3 was delayed, with reductions of 30–97 %. Additionally, 60 % of L1 larvae from females exposed to 22.4 and 37.3 mg/L Movento® 240 SC and 24.6 and 41.1 mg/L Envidor® 240 SC exhibited locomotor defects, including reduced head-thrust intensity, body curling, and diminished burrowing, highlighting significant generational impacts.</div></div>","PeriodicalId":276,"journal":{"name":"Chemosphere","volume":"395 ","pages":"Article 144816"},"PeriodicalIF":8.1,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145903925","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}