Fabrication of non-enzymatic glucose biosensor based on CuS/Ni3S4 reinforced microflowers

IF 8.1 2区环境科学与生态学 Q1 ENVIRONMENTAL SCIENCES

Chemosphere Pub Date : 2025-05-20 DOI:10.1016/j.chemosphere.2025.144450

Amir Hossein Ghanbari , Samira Fathi , Mohammad Hossein Sheikhi , Zoheir Kordrostami

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Abstract

Diabetes is a prevalent and life-threatening condition that is caused by uncontrolled changes in glucose concentration in the human body; therefore, daily monitoring of blood glucose concentration is a big necessity for almost 500 million diabetic patients worldwide. In this work, a low-cost and eco-friendly non-enzymatic electrochemical glucose biosensor based on copper sulfide (CuS) and nickel sulfide (Ni₃S₄) microstructures has been introduced. CuS Microflowers (MFs) were synthesized using a solvothermal method and reinforced by Ni₃S₄ nanoparticles (NPs) with a simple and one-step hydrothermal procedure. Cyclic voltammetry (CV) and chronoamperometry (CA) were employed to evaluate the electrochemical performance of the synthesized non-enzymatic glucose biosensors. Furthermore, the reinforced microflowers (RMFs) based biosensor exhibited an excellent improvement with selectivity toward glucose molecules, an LOD of 2.5 μM, and a great response time of less than 5 s. RMFs based biosensor showed two linear ranges of 0–1 mM and 1–5 mM with sensitivities of 303.85 μA/mM.cm² and 164.85 μA/mM.cm² respectively.

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基于cu /Ni3S4增强微花的无酶葡萄糖生物传感器的制备

糖尿病是一种常见的危及生命的疾病，是由人体内葡萄糖浓度不受控制的变化引起的；因此，每天监测血糖浓度对全球近5亿糖尿病患者来说是非常必要的。在这项工作中，介绍了一种基于硫化铜（cu）和硫化镍（Ni3S4）微结构的低成本、环保的非酶电化学葡萄糖生物传感器。采用溶剂热法合成了cu微花（MFs），并采用简单的一步水热法制备了Ni3S4纳米颗粒（NPs）。采用循环伏安法（CV）和计时安培法（CA）对合成的非酶葡萄糖生物传感器的电化学性能进行了评价。此外，基于增强微花（RMFs）的生物传感器对葡萄糖分子具有良好的选择性，LOD为2.5 μM，响应时间小于5 s。基于RMFs的生物传感器具有0 ~ 1 mM和1 ~ 5 mM两个线性范围，灵敏度为303.85 μA/mM。和164.85 μA/mM。分别平方厘米。

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来源期刊

Chemosphere 环境科学-环境科学

CiteScore

15.80

自引率

8.00%

发文量

4975

审稿时长

3.4 months

期刊介绍： Chemosphere, being an international multidisciplinary journal, is dedicated to publishing original communications and review articles on chemicals in the environment. The scope covers a wide range of topics, including the identification, quantification, behavior, fate, toxicology, treatment, and remediation of chemicals in the bio-, hydro-, litho-, and atmosphere, ensuring the broad dissemination of research in this field.