Ecotoxicology and Environmental Safety最新文献

{"title":"Bioaugmentation strategies in co-composting anaerobically digested food waste with agricultural by-products: Enhancing fertilizer quality and microbial communities.","authors":"Xuezhi Wang, Guyu You, Chenchen Liu, Yuan Sun","doi":"10.1016/j.ecoenv.2024.117539","DOIUrl":"https://doi.org/10.1016/j.ecoenv.2024.117539","url":null,"abstract":"<p><p>Effective management of urban solid waste is critical for achieving sustainable development goals. One key aspect of this challenge is the recycling of anaerobically digested residues from anaerobic digestion of food waste, which plays a pivotal role in promoting sustainability. However, there is a gap in understanding the feasibility and effectiveness of converting these digested residues into valuable fertilizers through composting. Addressing this gap, the present study explored the potential of composting anaerobically digested residue and evaluated the quality of the co-compost products. In this study, we investigated the composting process using a mixture of rice straw, food waste, sheep manure and mature composted residues (RFM group) alongside the anaerobically digested residues. The results demonstrated that the composting process quickly reached the thermophilic stage, during which NH⁺₄-N concentrations increased and C/N ratio decrease. The RFM group exhibited the highest humic acid content compared to other groups. Additionally, microbial analysis revealed key species such as Clostridium, Moheibacter, Bacillus, Thermobacillus, and Pseudogracilibacillus as major contributors to the composting process. The germination index (GI) test indicated that the co-composted residues were non-toxic to plants, suggesting their suitability as a fertilizer. All these works indicated that the addition of rice straw, food waste, and mature composted residues to anaerobically digested materials significantly enhanced the composting process, resulting in a high-quality co-compost. This approach not only provided a promising method for recycling food waste but also contributed to the broader goal of sustainable solid waste management.</p>","PeriodicalId":303,"journal":{"name":"Ecotoxicology and Environmental Safety","volume":"290 ","pages":"117539"},"PeriodicalIF":6.2,"publicationDate":"2024-12-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142862732","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Environmental DNA-based assessment of multitrophic biodiversity in a typical river located in the Loess Plateau, China: Influence of PAHs and suspended sediments.","authors":"Qian Li, Yulu Tian, Yongrong Hao, Chengkai Qu, Rungnapa Tagun, Hisato Iwata, Jiahua Guo","doi":"10.1016/j.ecoenv.2024.117568","DOIUrl":"https://doi.org/10.1016/j.ecoenv.2024.117568","url":null,"abstract":"<p><p>Polycyclic aromatic hydrocarbon (PAH) pollution and high suspended sediment (SS) contents are significant anthropogenic and natural stressors that threaten aquatic biodiversity. However, the characteristics of multitrophic biological communities and their co-occurrence patterns in response to PAHs in sediment-laden rivers remain unclear. This study investigated the spatial distribution of species across three trophic levels, including algae, metazoan, and fish, in the Beiluo River on the Loess Plateau, China, using environmental DNA metabarcoding. Biodiversity was assessed in relation to 16 PAHs, SS, and environmental variables. The PAH in the dissolved phase ranged from 19.70 to 1613.30 ng/L dominated by low molecular weight (LMW) PAHs. Partial least squares path modeling (PLS-PM) revealed a negative correlation between PAH distribution and SS in the river. In terms of biodiversity, the richness and Shannon index of algae (Chlorophyta and Dinophyceae) were positively associated with acenaphthene (ACE) levels. Conversely, the Shannon index and richness of metazoans (Rotifera and Arthropoda) appeared to decline in response to Benzo[a]anthracene (BaA) and pyrene (PYR). Fishes (Cypriniformes and Clupeiformes) demonstrated greater tolerance to PAH contamination than algae and metazoans, and their reduced richness and Shannon index were linked to the high SS loads (> 0.45 μm). The co-occurrence patterns highlighted a stronger association connection between algae and metazoan communities than fish. This study provides valuable insights into how PAHs could reshape the structure of riverine multitrophic communities under conditions of elevated SS loads.</p>","PeriodicalId":303,"journal":{"name":"Ecotoxicology and Environmental Safety","volume":"290 ","pages":"117568"},"PeriodicalIF":6.2,"publicationDate":"2024-12-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142862736","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"NUDT21 regulates lysyl oxidase-like 2(LOXL2) to influence ECM protein cross-linking in silica-induced pulmonary fibrosis.","authors":"Lan Peng, Wenqing Sun, Demin Cheng, Xinying Jia, Wenxiu Lian, Ziwei Li, Haojie Xiong, Ting Wang, Yi Liu, Chunhui Ni","doi":"10.1016/j.ecoenv.2024.117572","DOIUrl":"https://doi.org/10.1016/j.ecoenv.2024.117572","url":null,"abstract":"<p><p>Silicosis is a disease caused by prolonged exposure to silica dust. It is the most typical, rapidly progressive, and fatal form of pneumoconiosis. Currently, there is no specific medication available for the treatment of silicosis. LOXL2 is a copper-dependent lysine oxidase whose main function is to catalyze the cross-linking of extracellular matrix components, particularly collagen and elastin. However, few researchers have investigated the role of LOXL2 in the pathogenesis of silicosis. In this study, we demonstrated that LOXL2 is upregulated in silica-inhaled mouse lung tissue and in a TGF-β-induced fibroblast model. In vitro, we confirmed that LOXL2 functions to promote ECM deposition by binding directly to collagen and elastin. We then used scavenger receptor cysteine-rich (SRCR) domains to show that LOXL2 can induce fibrosis independently of its enzymatic activity. Furthermore, we discovered that NUDT21, the LOXL2 upstream regulatory mechanism of LOXL2, alters LOXL2's 3'UTR usage by substituting alternative polyadenylation (APA), thereby modulating LOXL2 expression. By injecting LOXL2 siRNA-loaded liposomes into the tail vein of mice in the silica dust-treated mouse pulmonary fibrosis model, the severity of lung fibrosis was significantly reduced. In this context, LOXL2 is regulated by NUDT21 and may affect pulmonary fibrosis by influencing the cross-linking of ECM proteins. Our research provides a scientific basis for the development of new anti-fibrosis treatment strategies.</p>","PeriodicalId":303,"journal":{"name":"Ecotoxicology and Environmental Safety","volume":"290 ","pages":"117572"},"PeriodicalIF":6.2,"publicationDate":"2024-12-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142862766","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Assessment of trace elements contamination and human health risk based on Monte Carlo simulation in a karst groundwater system affected by industrial activities.","authors":"Liyun Yang, Qixin Wu, Shilin Gao, Meixue Peng, Jianping Zhu, Jie Zeng, Li Shi, Xinghe Li","doi":"10.1016/j.ecoenv.2024.117550","DOIUrl":"https://doi.org/10.1016/j.ecoenv.2024.117550","url":null,"abstract":"<p><p>Groundwater in karst regions is a vital drinking water source, but it is highly susceptible to contamination from industrial activities, which exacerbate pollution and pose health risks. This study investigated the concentration, spatial distribution, quality, health risks and sources of trace elements (TEs) in groundwater within a newly established industrial park in Guiyang, a representative city with a karst landscape. The results indicated that the trace element concentrations followed the order: Ti > Fe > Al > Ni > Cr > Mn > V > Cu > As > Co. Correlation Analysis (CA) and Hierarchical Cluster Analysis (HCA) suggested that the sources of TEs are multifaceted, with industrial activities identified as the primary influencing factor. Monte Carlo simulations revealed that the non-carcinogenic risk (NCR) associated with each element was negligible. However, due to industrial activities, Cr, Ni and As exhibited significant carcinogenic risks. As one of the characteristic pollutants of the electroplating industry, Cr presented the highest potential risk. The total carcinogenic risks (TCR) for adults and children were 3.24E-05 and 3.78E-05, respectively, both exceeding the acceptable risk threshold of 1E-06. These results make a meaningful contribution to the management of vulnerable aquifers in karst industrial areas, with an emphasis on protection against TEs contamination, which is critical for ensuring groundwater safeguard and protecting public health.</p>","PeriodicalId":303,"journal":{"name":"Ecotoxicology and Environmental Safety","volume":"290 ","pages":"117550"},"PeriodicalIF":6.2,"publicationDate":"2024-12-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142862729","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The ameliorative effects of melatonin against BDE-47-induced hippocampal neuronal ferroptosis and cognitive dysfunction through Nrf2-Chaperone-mediated autophagy of ACSL4 degradation.","authors":"Quan Yuan, Mingwei Wang, Zhaoxiang Zhang, Ruofei Wang, Dechao Wang, Zichun Sang, Pu Zhao, Xiaoli Liu, Xiaoying Zhu, Gaofeng Liang, Hua Fan, Dongmei Wang","doi":"10.1016/j.ecoenv.2024.117542","DOIUrl":"https://doi.org/10.1016/j.ecoenv.2024.117542","url":null,"abstract":"<p><p>Recent studies demonstrate that lipid peroxidation-induced ferroptosis participates in 2,2',4,4'-tetrabromodiphenyl ether (BDE-47)-evoked neurotoxicity and cognitive dysfunction. Melatonin has been indicated to confer neuroprotection against brain diseases via its potent anti-ferroptotic effects. Therefore, this study aims to explore whether melatonin can mitigate BDE-47-elicited cognitive impairment via suppressing ferroptosis, and further delineate the underlying mechanisms. Our results found that melatonin administration effectively inhibited BDE-47-induced ferroptosis in mice hippocampi and murine hippocampal neuronal HT-22 cells. Acyl-CoA synthetase long-chain family member 4 (ACSL4), a key lipid metabolism enzyme dictating ferroptosis sensitivity, accompanied by higher MDA and lipid reactive oxygen species (ROS), was remarkably increased under BDE-47 stress, while melatonin supplementation could suppress the elevated ACSL4 in vivo and in vitro. Furthermore, melatonin facilitated lysosomal ACSL4 degradation through enhancing lysosome-associated membrane protein type 2a (LAMP2a) expression and chaperone-mediated autophagy (CMA) activity, while LAMP2a knockdown abrogated the positive effects of melatonin on ACSL4 elimination in BDE-47-treated HT-22 cells. Moreover, nuclear factor erythroid 2-related factor 2 (Nrf2) activation by melatonin contributed to LAMP2a upregulation and CMA of ACSL4 and subsequent neuronal ferroptosis. Importantly, melatonin, CMA activator CA77.1, and ACSL4 inhibitor rosiglitazone (RSG) administration substantially attenuated neuronal/synaptic injury and cognitive deficits following BDE-47 exposure. Taken together, these findings revealed that melatonin could prevent BDE-47-provoked ferroptosis in the hippocampal neurons and mitigate cognitive dysfunction by facilitating ACSL4 degradation via Nrf2-chaperone-mediated autophagy. Therefore, melatonin might be a potential candidate for treating BDE-47-elicited neurotoxicity and neurobehavioral disorder.</p>","PeriodicalId":303,"journal":{"name":"Ecotoxicology and Environmental Safety","volume":"290 ","pages":"117542"},"PeriodicalIF":6.2,"publicationDate":"2024-12-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142862808","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Enhancing soil quality in soybean cultivation: Mycorrhizal technology combined with intercropping under high cadmium stress.","authors":"Xiaohui Wang, Xiaoxu Fan, Wei Chang, Kun Li, Mengmeng Zhang, Gaozhong Pu, Alexander V Kurakov, Yuan Ping, Fuqiang Song","doi":"10.1016/j.ecoenv.2024.117558","DOIUrl":"https://doi.org/10.1016/j.ecoenv.2024.117558","url":null,"abstract":"<p><p>Cadmium (Cd) contamination presents a serious challenges for sustainable agriculture. This study evaluated the combined impact of arbuscular mycorrhizal fungi (AMF) inoculation and intercropping with Solanum nigrum on soil microbial diversity, enzyme activity, and environmental factors in soybean cultivation under high Cd stress. The combined treatment effectively reduced bioavailable Cd in soil, with the acid-soluble Cd fraction at 19.57 mg/kg and the reducible Cd fraction at 61.35 %, resulting in safe soybean grain Cd levels (2.63 mg/kg, below the 3 mg/kg organic standard). Illumina NovaSeq sequencing analysis revealed that key bacterial taxa, including Bradyrhizobium and PMMR1, were correlated with reduced Cd uptake in grains. Although bacterial α diversity increased, microbial network stability decreased in response to Cd, AMF inoculation, and intercropping. The combined treatment also enhanced soil enzyme activity by regulating the relative abundance of dominant or key genera such as Subgroup_6, Rokubacteriales and Pseudarthrobacter. Notably, catalase activity was 97.25 % higher in the combined treatment compared to monoculture without AMF colonization under high Cd conditions. These findings demonstrate the synergistic potential of AMF inoculation and S. nigrum intercropping as a sustainable approach to mitigate Cd contamination in crops while improving soil health in Cd-contaminated environments.</p>","PeriodicalId":303,"journal":{"name":"Ecotoxicology and Environmental Safety","volume":" ","pages":"117558"},"PeriodicalIF":6.2,"publicationDate":"2024-12-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142862690","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Adsorption properties and competitive adsorption mechanism exhibited by carbon-nanotube-modified biochar for removal of crude oil and Ni(II) pollutants from water.","authors":"Di Cao, Ruiyan Niu, Guanglu Mo, Huiwen Deng, Rui Liu, Jie Liu, Jialin Fan","doi":"10.1016/j.ecoenv.2024.117557","DOIUrl":"https://doi.org/10.1016/j.ecoenv.2024.117557","url":null,"abstract":"<p><p>Carbon-nanotube-modified biochar (CNT3-CBC) with a nanostructured surface was prepared by using cattle manure as the raw material via the impregnation method. This modified biochar was then used to adsorb petroleum and Ni(II) from aqueous solutions. Various physicochemical characterization techniques were employed, including SEM, BET analysis, FTIR, and XPS. Kinetic and isothermal adsorption characteristics were analyzed. The influence of different biochar dosages, solution pH levels, and number of adsorption cycles on the efficiency of removal of crude oil and Ni(II) was meticulously evaluated. Results indicated that modified biochar had a higher surface area, a greater number of surface functional groups, and higher interaction forces compared to biochar. Adsorption kinetics and isotherms showed that modified biochar had a strong adsorption capacity. The experimental data conformed closely to the Elovich, Langmuir, and Freundlich adsorption models, underscoring the significant contributions of both physical and chemical adsorption mechanisms. Competitive adsorption of modified biochar in the co-sorption of petroleum and nickel solutions exists, and the modified biochar demonstrated high capacities for crude oil and Ni(II) in the competitive adsorption. The modified biochar prepared at a pyrolysis temperature of 800°C exhibited a superior adsorption performance, and the adsorption capacities of crude oil and Ni(II) were 303.03 mg·g^-1 and 32.87 mg·g^-¹ , respectively. Modified biochar has better regeneration potential after crude oil and Ni(II) adsorption, with the removal efficiency remaining above 50 % in the fourth cycle. As an efficient and environmentally friendly adsorbent, modified biochar shows great potential for removing crude oil and Ni(II) pollutants from water.</p>","PeriodicalId":303,"journal":{"name":"Ecotoxicology and Environmental Safety","volume":"290 ","pages":"117557"},"PeriodicalIF":6.2,"publicationDate":"2024-12-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142862725","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mitigation PFHxA-induced neurotoxicity in Carassius auratus brain cells by selenium-enriched Bacillus subtilis via the BDNF/PI3K/AKT/GSK-3β pathway.","authors":"Yu-Ting Lu, Zheng-Yao Guo, Lei Guo, Yu-Hua He, Li-Ming Liu, Xue Jiao, Yue-Hong Li","doi":"10.1016/j.ecoenv.2024.117567","DOIUrl":"https://doi.org/10.1016/j.ecoenv.2024.117567","url":null,"abstract":"<p><p>As emerging contaminants growing threat to aquatic organisms, explore effective mitigation strategies is particularly important. Our previous studies have shown that selenium-rich Bacillus subtilis can not only alleviate the cause of brain damage by perfluorohexanoic acid (PFHxA) in Carassius auratus via the intestinal axis of the brain, but its metabolites can also alleviate PFHxA toxicity. This study further explores the potential mechanism through in vitro experiments. Findings demonstrate that apoptosis caused by PFHXA is effectively reduced with the use of selenium-rich Bacillus subtilis, which operates through the BDNF/PI3K/AKT/GSK-3β signalling pathway. Furthermore, utilisation of LY294002 and LICl inhibitors provided additional confirmation of the pivotal function of this pathway in neuroprotection. Our study results emphasize the significance of the PI3K/AKT/GSK-3β signalling pathway in promoting neuronal survival. Additionally, our findings establish a novel theoretical framework for using selenium-enriched Bacillus subtilis in environmental toxicology. Selenium-enriched Bacillus subtilis can be used as a novel microecological preparation. Implementing this approach could effectively counteract neurotoxic consequences of emerging contaminants, hence safeguarding and preserving aquatic ecosystems.</p>","PeriodicalId":303,"journal":{"name":"Ecotoxicology and Environmental Safety","volume":"290 ","pages":"117567"},"PeriodicalIF":6.2,"publicationDate":"2024-12-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142862765","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Environmental high temperature (heat stroke) causes articular cartilage damage in vivo and in vitro.","authors":"Sun Yingfei, Yang Feng, Ma Haoning","doi":"10.1016/j.ecoenv.2024.117535","DOIUrl":"https://doi.org/10.1016/j.ecoenv.2024.117535","url":null,"abstract":"<p><p>Heatstroke (HS) is gradually becoming a major challenge in the field of global public health with the trend of global warming. In recent years, extreme high-temperature weather events have occurred frequently in the world, which directly led to a significant increase in heatstroke. However, up to now, the potential pathological effects of HS on articular cartilage have not been revealed. Therefore, in our current work, we studied the damage of heat toxicity on chondrocytes in vitro. The results showed that heatstroke reduced the cell activity of chondrocytes and triggered a decrease in mitochondrial membrane potential and oxidative stress response. Further biochemical analysis showed that heatstroke caused chondrocyte PANoptosis. On this basis, we further analyzed the molecular mechanism of HS-induced cartilage damage. The results showed that HS activated ZBP-1-mediated PAN-apoptosis. In vivo, our group further evaluated the impact of HS on articular cartilage. The results showed that heatstroke caused damage to articular cartilage, and immunohistochemistry showed that heatstroke caused damage and programmed necrosis of cartilage tissue. On this basis, we evaluated the alleviating effect of FGF21 on HS-induced chondrocyte damage. The results showed that FGF21 could effectively alleviate the PANoptosis of chondrocytes caused by heatstroke via activating the AMPK signaling (at least partially). In summary, the current research lays a foundation for further exploring the cartilage damage caused by heatstroke.</p>","PeriodicalId":303,"journal":{"name":"Ecotoxicology and Environmental Safety","volume":"290 ","pages":"117535"},"PeriodicalIF":6.2,"publicationDate":"2024-12-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142862737","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"PLIN5 contributes to lipophagy of hepatic stellate cells induced by inorganic arsenic.","authors":"Haomiao Li, Xuri Xie, Tianming Qiu, Jingyuan Zhang, Jie Bai, Guang Yang, Ningning Wang, Xiaofeng Yao, Xiance Sun","doi":"10.1016/j.ecoenv.2024.117547","DOIUrl":"https://doi.org/10.1016/j.ecoenv.2024.117547","url":null,"abstract":"<p><p>Arsenic exposure triggers the activation of hepatic stellate cells (HSCs), resulting in liver fibrosis (LF). A significant decrease in lipid droplets marks the activation of HSCs. However, the exact underlying molecular mechanism remains elusive. Lipophagy, a specialized form of selective autophagy, is crucial for the degradation of lipid droplets to maintain intracellular lipid metabolism homeostasis. In this study, arsenic treatment induced lipophagy, as evidenced by the co-localization of LC3 with lipid droplets. Remarkably, arsenic exposure increased the expression levels of Perilipin 5 (PLIN5), a lipid droplet-associated protein, both at the mRNA and protein levels. Moreover, silencing PLIN5 influenced arsenic-induced lipolysis. Consequently, the results of this study indicate that PLIN5 serves as a substrate protein involved in arsenic-induced lipophagy. This research offers a novel perspective on the mechanisms of arsenic-induced HSCs activation and liver lipid metabolism, potentially guiding new strategies for the prevention and treatment of arsenic-related liver diseases.</p>","PeriodicalId":303,"journal":{"name":"Ecotoxicology and Environmental Safety","volume":"290 ","pages":"117547"},"PeriodicalIF":6.2,"publicationDate":"2024-12-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142862777","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}