Ecotoxicology and Environmental Safety最新文献

{"title":"Global, regional, and national burdens of non-alcoholic fatty liver disease attributable to smoking from 1990 to 2021","authors":"Pengyue Zhang ,&nbsp;Jie Zhu ,&nbsp;Xinlei Chen ,&nbsp;Chunhui Tao ,&nbsp;Jianmei Zhou ,&nbsp;Zhenhua Zhang ,&nbsp;Xiaodan Hong","doi":"10.1016/j.ecoenv.2025.118818","DOIUrl":"10.1016/j.ecoenv.2025.118818","url":null,"abstract":"<div><h3>Background</h3><div>Tobacco is a major environmental pollutant, and smoking is a recognized risk factor for non-alcoholic fatty liver disease (NAFLD). However, the global epidemiological burden of smoking-related NAFLD remains unclear. This study aimed to quantify the burden of NAFLD attributable to smoking from 1990 to 2021, focusing on disability-adjusted life years (DALYs), mortality rates, and temporal trends.</div></div><div><h3>Methods</h3><div>Data were extracted from the Global Burden of Disease Study 2021 and analyzed at global, regional, and national levels. Age, sex, region, and socio-demographic index (SDI) were included. Key measures included age-standardized DALY rates (ASDR), age-standardized mortality rates (ASMR), and average annual percentage changes (AAPCs). Trends were further stratified by age, sex, and SDI.</div></div><div><h3>Results</h3><div>Globally, the ASMR of NAFLD attributable to smoking demonstrated a upward trend (AAPC_ASMR=0.27[95 % CI, 0.17–0.37], <em>P</em> &lt; 0.001). The most substantial increases from 1990 to 2021 were observed in Australasia and Southern Latin America. The AAPC for ASDR was 2.89[95 %CI, 2.5–3.29] and 2.84[95 %CI, 2.16–3.52], respectively. The burden was significantly higher in males, with DALY rates rising with age and peaking at 65–69 years (8.84/100,000; 95 % UI: 2.77–15.69). An inverse U-shaped association between SDI and disease burden was noted. Join-point analysis revealed increasing trends in low-medium SDI regions and among females in high-SDI regions.</div></div><div><h3>Conclusion</h3><div>Despite declining smoking prevalence, the burden of smoking-related NAFLD continues to rise, especially in low-middle income regions and high-income females. Strengthened tobacco control and targeted NAFLD prevention strategies are urgently needed.</div></div>","PeriodicalId":303,"journal":{"name":"Ecotoxicology and Environmental Safety","volume":"303 ","pages":"Article 118818"},"PeriodicalIF":6.1,"publicationDate":"2025-08-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144780362","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Occurrence of cyclotriphosphazene derivatives in human urine: Assessment of human exposure","authors":"Kaiyuan Huang ,&nbsp;Yuxiang Weng ,&nbsp;Zebin Fang ,&nbsp;Luyuan Zhang ,&nbsp;Feng Xiao ,&nbsp;Weijian Fan ,&nbsp;Hanfeng Chen ,&nbsp;Hangbiao Jin","doi":"10.1016/j.ecoenv.2025.118774","DOIUrl":"10.1016/j.ecoenv.2025.118774","url":null,"abstract":"<div><div>Cyclotriphosphazene derivatives, commonly employed as flame retardants and electrolyte additives in lithium-ion batteries, have sparked concerns regarding their potential effects on human health due to environmental release. Despite their widespread use, the detection of these compounds in human urine, a key medium for evaluating exposure to environmental pollutants, remains underexplored. In this study, seven cyclotriphosphazene derivatives were analyzed in urine samples obtained from 238 individuals residing in Hangzhou City, China. Results showed that hexafluorocyclotriphosphazene (HFCTP; mean 1.2 ng/mL, range &lt; LOD–7.7 ng/mL) and ethoxy(pentafluoro)cyclotriphosphazene (EPFCTP; 0.96 ng/mL, &lt; LOD–11 ng/mL) were the predominant cyclotriphosphazene derivatives in human urine. Male subjects (0.96 ± 0.33 ng/mL) had much higher (<em>p</em> = 0.029) mean urinary levels of pentafluoro(phenoxy)cyclotriphosphazene (PFPCTP) compared to female subjects (0.56 ± 0.23 ng/mL). We observed a significantly negative relationship between age of participants and their urinary concentrations of HFCTP (<em>p</em> &lt; 0.01) and PFPCTP (<em>p</em> &lt; 0.01). HFCTP had the highest mean daily exposure value (51 ng/kg bw/day), which was followed by EPFCTP (35 ng/kg bw/day) and PFPCTP (30 ng/kg bw/day). As far as we are aware, this is the first study to provide a comprehensive analysis of urinary occurrence and concentrations of cyclotriphosphazene derivative in the general population, which is necessary to conduct a thorough human risk assessment.</div></div>","PeriodicalId":303,"journal":{"name":"Ecotoxicology and Environmental Safety","volume":"303 ","pages":"Article 118774"},"PeriodicalIF":6.1,"publicationDate":"2025-08-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144780449","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Phase partitioning and toxicity prediction of metals in blood plasma, platelets, leukocytes and erythrocytes","authors":"Yubing Dai ,&nbsp;Jiaxin Liu ,&nbsp;Naibing Liang ,&nbsp;Zhangpeng Guo ,&nbsp;Jing Jin ,&nbsp;Congjie Bi ,&nbsp;Haijun Zhang ,&nbsp;Ningbo Geng ,&nbsp;Jiping Chen","doi":"10.1016/j.ecoenv.2025.118803","DOIUrl":"10.1016/j.ecoenv.2025.118803","url":null,"abstract":"<div><div>Plasma and blood cells may exist different phase partitioning of elements due to their distinct properties and functions, while the distribution patterns of other elements across plasma, platelets, leukocytes, and erythrocytes remain largely unexplored. This study developed a method to rapidly separate these fractions of human blood and quantify 22 elements in each fraction. Notably, elements like Fe, Zn, and Rb were higher in erythrocytes, whereas Cd, Cr, V, and Sr were concentrated in leukocytes. Most metals detected in plasma account for &lt; 40 % of the total concentration in blood, particularly toxic metals, with Cr, As, Cd, Hg, and Pb accounting for 63–75 % in blood cells, suggesting plasma-based assessments may underestimate actual exposure. Metal concentrations in plasma were positively correlated with those in whole blood (<em>ρ</em> ≥ 0.48), except for Fe (<em>ρ</em> = 0.13). We derived empirical ratios to estimate the internal exposure levels of elements from plasma to blood. Finally, we prioritized the assessment of potential acute and non-cancer risks associated with five toxic metals. As evidenced by PrHQ values, the toxicity level of As were the highest. Notably, the PrHQ values for these toxic metals in whole blood were approximately three times higher than those detected in plasma.</div></div>","PeriodicalId":303,"journal":{"name":"Ecotoxicology and Environmental Safety","volume":"303 ","pages":"Article 118803"},"PeriodicalIF":6.1,"publicationDate":"2025-08-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144780448","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Zearalenone at environmental levels promoted ER- positive breast cancer cell lines through the hedgehog pathway","authors":"Ling Xu ,&nbsp;Hui Zhou ,&nbsp;Yuting Zhong ,&nbsp;Linnan Zhao ,&nbsp;Jiangying Qian ,&nbsp;Lei Ding ,&nbsp;Xuexiu Chang ,&nbsp;Christopher Kassotis ,&nbsp;Qinghua Cui","doi":"10.1016/j.ecoenv.2025.118813","DOIUrl":"10.1016/j.ecoenv.2025.118813","url":null,"abstract":"<div><div>Zearalenone (ZEA) has been recognized as a common exogenous nonsteroidal estrogen in environments which possessed a disruptive effect on organisms. Exposure to exogenous estrogen has been revealed to affect breast cancer development. However, whether ZEA exerts estrogenic effects to influence and cause breast cancer is poorly documented. We hypothesized that ZEA might act as an estrogen and causative factor in breast cancer, mainly due to its similarity to naturally occurring estrogens. The aim of this study was to further explore the potential risks of ZEA by comparing the effects of ZEA on the proliferation and invasion of estrogen receptor (ER) positive/negative breast cancer cell lines, and to explore its underlying molecular mechanisms. We found that low ZEA concentrations, similar with the real environment, promoted the proliferation, migration and invasion only in ER-positive breast cancer cells, while high concentrations of ZEA inhibited malignant biological behaviors in both ER positive and negative breast cancer cells. Consistently, ZEA demonstrated the same biphasic effect (promotion at low dose and inhibition at high dose) on cell stemness and epithelial mesenchymal transition processes, which were further confirmed to be controlled by the Hedgehog pathway. These results highlight the additional health risks posed by ZEA, which warrant greater attention in environmental management.</div></div>","PeriodicalId":303,"journal":{"name":"Ecotoxicology and Environmental Safety","volume":"303 ","pages":"Article 118813"},"PeriodicalIF":6.1,"publicationDate":"2025-08-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144780367","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Environmental exposure and pulmonary toxicity: Integrated computational network toxicology and RNA-seq analysis uncovers public health implications of sulfur mustard contamination","authors":"Xinkang Zhang ,&nbsp;Jinfeng Cen ,&nbsp;Qingqiang Xu,&nbsp;Guanchao Mao,&nbsp;Zhipeng Pei,&nbsp;Shanshan Zhang,&nbsp;Wenqi Meng,&nbsp;Mingxue Sun","doi":"10.1016/j.ecoenv.2025.118779","DOIUrl":"10.1016/j.ecoenv.2025.118779","url":null,"abstract":"<div><div>Sulfur mustard (SM), a persistent environmental contaminant in conflict zones, induces severe pulmonary and systemic toxicity through airborne, soil, and groundwater exposure routes. While the mechanisms and core targets of SM remain complex, computational network toxicology predicted six core targets (PTGS2, ESR1, APP, SIRT1, ACE, CASP3) converging on environmental stress responses, neurotoxicity cascades, and metabolic dysregulation. These alterations drive immunotoxicity, inflammatory responses, cytogenetic mutations, and ultimately leading to lung injury. Critically, RNA-seq validation confirmed CASP3 elevation (1.4-fold) and SIRT1 suppression (1.5-fold) as exposure biomarkers directly informing remediation policies for contaminated ecosystems. This integrated computational-experimental approach reveals novel therapeutic strategies against SM’s public health impact.</div></div>","PeriodicalId":303,"journal":{"name":"Ecotoxicology and Environmental Safety","volume":"303 ","pages":"Article 118779"},"PeriodicalIF":6.1,"publicationDate":"2025-08-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144780363","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"No evidence for behavioral or physiological effects of nanoplastics ingestion in the fruit fly Drosophila melanogaster","authors":"Chloé M.C. Richard ,&nbsp;David Renault ,&nbsp;Clarisse Cadot ,&nbsp;Hervé Colinet ,&nbsp;Stéphane A.P. Derocles ,&nbsp;Silvia Argelia Peraza Ku ,&nbsp;Karine Salin ,&nbsp;Mélanie Boël","doi":"10.1016/j.ecoenv.2025.118811","DOIUrl":"10.1016/j.ecoenv.2025.118811","url":null,"abstract":"<div><div>Plastic pollution increases worldwide, releasing small plastic particles into the environment, such as nanoplastics (NP) that affect living organisms. NP can penetrate biological membranes and interact with cellular components such as mitochondria. However, the effects of NP on terrestrial insects, the most diverse and abundant taxa, remains poorly studied compared to aquatic species. Our study assesses the effect of nanoplastics on the emergence rate, mitochondrial activity, metabolism, body mass, and locomotor activity in <em>Drosophila melanogaster</em> (Meigen, 1830, Diptera: Drosophilidae), a terrestrial insect. Three experimental groups were compared: a control group (C) with flies fed food without NP, a low contamination group (LOW) with flies fed food containing 1 µg/g of NP of different sizes (20, 80 and 200 nm), and a high contamination group (HIGH) with flies fed food containing 500 µg/g of NP of the same classes of sizes. Low and High groups were exposed to polystyrene NP for their entire development cycle. NP ingestion did not affect the number of pupae and adults, emergence rate, mitochondrial activity, metabolism and body mass. The locomotor activity of the flies was also unaffected by ingestion of NP. These results, compared with those reported in the literature, showed that the effect of nanoplastics on living organisms might depend on the species and polymer nature. The absence of detectable effects on flies is positive for the ecology of the species, constantly exposed to plastic pollution. Further studies in this area are still needed to fully determine the effects of NP on <em>Drosophila</em> biology and behavior.</div></div>","PeriodicalId":303,"journal":{"name":"Ecotoxicology and Environmental Safety","volume":"303 ","pages":"Article 118811"},"PeriodicalIF":6.1,"publicationDate":"2025-08-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144780366","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Unveiling the pathogenic mechanisms of polyethylene terephthalate-microplastic-driven osteoarthritis and rheumatoid arthritis: PTGS2 signaling hub-oriented toxicity profiling","authors":"Jingkai Di ,&nbsp;Shuang Wang ,&nbsp;Lujia Liu ,&nbsp;Keying Rong ,&nbsp;Zijian Guo ,&nbsp;Yingda Qin ,&nbsp;Feida Wang ,&nbsp;Chuan Xiang","doi":"10.1016/j.ecoenv.2025.118816","DOIUrl":"10.1016/j.ecoenv.2025.118816","url":null,"abstract":"<div><div>In recent years, health problems caused by microplastics (MPs) have attracted much attention. The pathogenic mechanisms of them in osteoarthritis (OA) and rheumatoid arthritis (RA) are still unclear and urgently need in-depth exploration. The targets related to OA and RA of Polyethylene Terephthalate (PET) were extracted from databases such as PubChem. Additionally, investigations into potential mechanisms were carried out through the utilization of Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) analyses. Furthermore, six algorithms such as Closeness and the ROC curve were used to further screen the target proteins with high correlation. The stability of the interaction between the target protein and PET-MPs was verified by leveraging molecular docking and molecular dynamics (MD) simulations. Western blot (WB) and quantitative real-time polymerase chain reaction (qRT-PCR) experiments were conducted to verify the predicted results. The study identified 59 potential PET targets related to OA and 53 targets related to RA. Among them, biological processes such as γ-aminobutyric acid (GABA) and neural membrane potential regulation, as well as C-type lectin receptors and the neural active ligand-receptor interaction pathway were enriched significantly. In addition, different biological processes and signaling pathways specifically affect the processes of OA and RA. After further screening, two proteins such as AKT1 and four proteins such as NR3C1 have relatively high predictive values in OA and RA respectively. Among them, PTGS2 and PET-MPs are strongly correlated targets causing injuries in OA and RA. The in vitro experiments further confirmed that PET-MPs significantly increased the expression of PTGS2 during the progression of OA and RA. This study clarified for the first time the specific mechanisms and targets of PET-MPs in inducing OA and RA, providing a theoretical basis and technical reference for PET-MPs-related diseases.</div></div>","PeriodicalId":303,"journal":{"name":"Ecotoxicology and Environmental Safety","volume":"303 ","pages":"Article 118816"},"PeriodicalIF":6.1,"publicationDate":"2025-08-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144780365","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Economic and health impacts of PM2.5 pollution in China’s urban air: Assessing the financial burden","authors":"Lingli Yang ,&nbsp;Fang Bao","doi":"10.1016/j.ecoenv.2025.118575","DOIUrl":"10.1016/j.ecoenv.2025.118575","url":null,"abstract":"<div><div>Emerging evidence suggests that fine particulate matter (PM₂.₅) not only contributes to significant public health risks but also imposes substantial economic burdens in China’s rapidly urbanising regions. This study evaluates the concentrations, exposure risks, and cardiotoxic effects of PM₂.₅-bound benzotriazoles (BTRs)—a class of organic pollutants with growing toxicological concern—in the urban atmospheres of Chengdu, Wuhan, and Shijiazhuang during the winter season of 2020–2021. High-volume air sampling and GC-EI-MS/MS analysis revealed that the average total BTR concentration (∑BTRs) was highest in Shijiazhuang (5.73 ng·m⁻³)<strong>,</strong> followed by Wuhan (3.91 ng·m⁻³) and Chengdu (2.84 ng·m⁻³). Among the five detected congeners, 1-methylbenzotriazole (1TTR) and 5-methylbenzotriazole (5TTR) were predominant, comprising over 75 % of the total burden. Inhalation exposure assessments indicated that preschool children in Shijiazhuang experience the highest estimated daily intake (EDI), reaching 3.46 ng·kg⁻¹ ·day⁻¹ at the 95th percentile. In vitro toxicity tests using neonatal rat cardiomyocytes identified 1TTR as the congener with the strongest mitochondrial toxicity, with a low LC₅₀ of 715.3 μM, inducing significant increases in apoptosis and oxidative stress markers. Untargeted metabolomics revealed disruptions in arginine biosynthesis, glutathione metabolism, and fatty acid β-oxidation, suggesting potential impairment of cardiac energy production pathways. These health impacts were modelled to estimate indirect economic costs—including projected cardiovascular healthcare expenditures and productivity losses—revealing a combined financial burden exceeding ¥2.1 billion annually across the three cities. The findings emphasise the urgency of regulating PM₂.₅-bound organic pollutants like BTRs and incorporating health-based cost assessments into urban environmental policies. Targeted mitigation strategies and pollution-specific monitoring are critical for reducing both public health risks and economic damages linked to air pollution in China’s metropolitan areas.</div></div>","PeriodicalId":303,"journal":{"name":"Ecotoxicology and Environmental Safety","volume":"303 ","pages":"Article 118575"},"PeriodicalIF":6.1,"publicationDate":"2025-08-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144780364","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"No detectable impact of chronic oral lactic acid exposure on honey bee health: Insights from survival, lactate accumulation and head transcriptome","authors":"Caroline Vilarem ,&nbsp;Vincent Piou ,&nbsp;Lucie Bouly ,&nbsp;Frédéric Julien ,&nbsp;Rachel Fourdin ,&nbsp;Nathalie Vialaneix ,&nbsp;Matthias Zytnicki ,&nbsp;Angélique Vétillard","doi":"10.1016/j.ecoenv.2025.118807","DOIUrl":"10.1016/j.ecoenv.2025.118807","url":null,"abstract":"<div><div>Natural acids such as oxalic, formic or lactic acids are used as alternative treatments against <em>Varroa destructor</em>, the parasitic mite of honey bees (<em>Apis mellifera</em>). Lactic acid has recently been shown to impair mites’ grip skills through local action after exposure of adult honey bees. However, little is known about the lethal and sublethal effects of lactic acid on honey bees. In this work, we investigated the effects of chronic oral exposure to lactic acid through a contaminated diet on age-controlled worker bees. We monitored survival under artificial conditions, quantified lactate levels in various worker organs (the digestive tract, the thorax, the fat body, the head and the haemolymph) and analysed the transcriptome of the workers’ heads. Our results indicate that consuming lactic acid at residual concentration (1.5 mg/mL) did not impact the survival. No lactate accumulation was detected in any of the honey bee organs analysed. Furthermore, transcriptomic analysis on the bees’ heads revealed no differences in gene expression. While further research on sublethal effects is still needed, this work provides one of the first reports on the off-target effects of lactic acid on honey bee health.</div></div>","PeriodicalId":303,"journal":{"name":"Ecotoxicology and Environmental Safety","volume":"303 ","pages":"Article 118807"},"PeriodicalIF":6.1,"publicationDate":"2025-08-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144780450","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Assessing the impact of urban form on PM2.5 concentration along roads in a city with mobile monitoring and machine learning models","authors":"Mingyue Xi ,&nbsp;Xuegang Chen ,&nbsp;Jiayu Fan","doi":"10.1016/j.ecoenv.2025.118789","DOIUrl":"10.1016/j.ecoenv.2025.118789","url":null,"abstract":"<div><div>Due to urbanization, air pollution has become one of the most serious environmental problems, threatening human health and causing adverse effects on other environments. In order to improve air quality, it is necessary to analyze the relationship between urban form and air pollution and propose optimization strategies. This study is dedicated to collecting PM_2.5 concentration data on different grades of roads through mobile monitoring technology, which is then corrected using national fixed monitoring stations. At the same time, combining the meteorological data obtained during the experiment by fixed-point monitoring, RF model was used to deeply analyze the influence of urban form on PM_2.5 concentration, providing a scientific and effective reference basis for urban planning. The results showed that the PM_2.5 concentration in autumn was significantly higher than that in summer, and the pollution in the southern region was heavier than that in the northern region. The influence of different urban forms on buffer radius is different. Mean building height, population density, floor area ratio and impervious surface proportion are the key urban form indicators affecting PM_2.5. In future urban planning, it is recommended to reasonably control building heights within a 500-meter buffer zone along roads, optimize urban building layouts, and promote population relocation from old urban areas to expand urban green space and alleviate PM_2.5 pollution in Urumqi. Therefore, quantitative analysis of the relationship between PM_2.5 concentrations and urban form elements can assist decision-makers in urban planning and management.</div></div>","PeriodicalId":303,"journal":{"name":"Ecotoxicology and Environmental Safety","volume":"303 ","pages":"Article 118789"},"PeriodicalIF":6.1,"publicationDate":"2025-08-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144772056","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}