Ecotoxicology and Environmental Safety最新文献

{"title":"Phthalates in the environment of China: A scoping review of distribution, anthropogenic impact, and degradation based on meta-analysis.","authors":"Zhigang Cui, Ce Shi, Lanting Zha, Jiaman Liu, Yinchu Guo, Xiaohan Li, Enjiao Zhang, Zhihua Yin","doi":"10.1016/j.ecoenv.2024.117659","DOIUrl":"10.1016/j.ecoenv.2024.117659","url":null,"abstract":"<p><p>Phthalates (PAEs) are a group of endocrine-disrupting environmental chemicals (EEDs) that pose significant risks to human health. PAEs are widespread in various environmental media, including air, dust, water, and soil, and are subject to both horizontal and vertical migration. Human activities significantly influence the distribution of PAEs, yet current research on this relationship remains limited. In this study, we first describe the hot issues of PAEs in the environment through bibliometrics, and then review published related studies. We outline the global distribution of PAEs in different media and conducted a comparative analysis of their composition. Principal component analysis (PCA) revealed PAEs differences in environmental mediums and geographic locations. Correlation analysis between PAEs composition and human activities in China further demonstrated that PAE concentrations were closely linked to agricultural and industrial activities. We also discussed the biodegradation and abiotic degradation of PAEs, finding that bacteria play a crucial role in their degradation in soil. This study aims to assess the distribution, transfer, impact, and degradation of PAEs, providing insights for the prevention and remediation of PAE pollution.</p>","PeriodicalId":303,"journal":{"name":"Ecotoxicology and Environmental Safety","volume":"289 ","pages":"117659"},"PeriodicalIF":6.2,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142941931","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"BPZ inhibits early mouse embryonic development by disrupting maternal-to-zygotic transition and mitochondrial function.","authors":"Zhiming Ding, Huilei Chen, Huiru Cheng, Caiyun Wu, Hongzhen Ruan, Bingjing Zhu, Ping Zhou, Zuying Xu, Huifen Xiang","doi":"10.1016/j.ecoenv.2025.117693","DOIUrl":"10.1016/j.ecoenv.2025.117693","url":null,"abstract":"<p><p>The use of Bisphenol A (BPA) has been widely restricted due to its adverse health effects. Bisphenol Z (BPZ) is used as an alternative to BPA, and humans are widely exposed to BPZ through various routes. Recent studies have shown that BPZ exposure adversely affects mouse oocyte meiotic maturation. This study investigates the impact of BPZ exposure on early mouse embryonic development alongside an exploration of the underlying mechanisms. The findings reveal that exposure to BPZ leads to a reduction in early embryo quality and hinders developmental progression. RNA sequencing analysis has identified 593 differentially expressed genes as a result of BPZ exposure, highlighting considerable changes in early embryonic gene expression. Mechanistically, BPZ exposure inhibits the activation of the zygotic genome and impedes maternal mRNA degradation, thereby interfering with maternal-to-zygotic transition (MZT). Further analysis indicates compromised mitochondrial function, as evidenced by abnormal distribution, diminished membrane potential, and lower ATP levels. Consequently, BPZ-exposed embryos exhibit elevated levels of reactive oxygen species, superoxide anions, and oxidative DNA damage. Moreover, BPZ exposure is associated with an increase in γ-H2A.X expression. Additionally, BPZ exposure alters the expression levels of histone modifications, including H3K27me2, H3K27me3, H3K9me3, and H3K27ac, in early embryos. Collectively, BPZ exposure significantly impairs early embryo quality by disrupting mitochondrial function, inducing oxidative stress and DNA damage, altering histone modifications, and inhibiting MZT, ultimately resulting in hindered blastocyst formation. These findings underscore the profound adverse effects of BPZ on early embryonic development, indicating the need for caution when considering it as a safe alternative to BPA.</p>","PeriodicalId":303,"journal":{"name":"Ecotoxicology and Environmental Safety","volume":"289 ","pages":"117693"},"PeriodicalIF":6.2,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142942130","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Novel functional eQTL-SNPs associated with susceptibility to occupational pulmonary fibrosis: A multi-stage study.","authors":"Rui Zhao, Xiaobo Tao, Wendi Zhang, Siqi Li, Shenxuan Zhou, Anhui Ning, Zhenyu Li, Minjie Chu, Wei Wang, Junhong Jiang","doi":"10.1016/j.ecoenv.2025.117679","DOIUrl":"10.1016/j.ecoenv.2025.117679","url":null,"abstract":"<p><strong>Aim: </strong>Identifying the common functional single-nucleotide polymorphisms (SNPs) that can both affect the susceptibility to idiopathic pulmonary fibrosis (IPF) and silicosis.</p><p><strong>Methods: </strong>We first integrated the genome-wide association studies (GWASs) of IPF and silicosis to obtain the shared SNPs. Following this, functional expression quantitative trait locus (eQTL)-SNPs were identified by the GTEx database. This was followed by the validation of the correlation between these eQTL-SNPs and silicosis susceptibility through an additional case-control study including 194 silicosis cases and 235 healthy controls.</p><p><strong>Results: </strong>A total of 10 eQTL-SNPs that may affect silicosis susceptibility (P < 0.05) were obtained after the integration of the GWASs of IPF and silicosis, and a series of rigorous selection principles. Subsequently, the results of integrating the validation stage and the screening stage indicated that the variant T allele of rs1620530 located in the MAD1L1 (additive model: OR= 1.56, 95 % CI = 1.21-2.01, P = 0.001) and the variant G allele of rs2070063 located in the SERTAD2 (additive model: OR= 1.60, 95 % CI = 1.24-2.06, P < 0.001) were associated with increased silicosis susceptibility. The joint analysis indicated the risk of developing silicosis was higher in individuals who carried more unfavorable alleles of rs1620530 and rs2070063.</p><p><strong>Conclusions: </strong>The rs1620530 and rs2070063 may affect the silicosis susceptibility by regulating the expression of the MAD1L1 and SERTAD2, respectively. Further biological experiments are warranted to elucidate the underlying biological mechanisms between these two SNPs and the increased susceptibility to silicosis.</p>","PeriodicalId":303,"journal":{"name":"Ecotoxicology and Environmental Safety","volume":"289 ","pages":"117679"},"PeriodicalIF":6.2,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142963446","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sex steroid hormones mediate the association between neonicotinoids and obesity among children and adolescents.","authors":"Qian Su, Jinzhu Luo, You Zhou, Miao Liu, Shaohua Zeng, Yin Li, Jieying Gao","doi":"10.1016/j.ecoenv.2025.117708","DOIUrl":"10.1016/j.ecoenv.2025.117708","url":null,"abstract":"<p><strong>Background: </strong>Neonicotinoids are the most widely used insecticide worldwide. Toxicological and epidemiological studies suggest that exposure to neonicotinoid may be linked to the development of childhood obesity. However, the evidence is limited.</p><p><strong>Objective: </strong>To investigate the association between neonicotinoid exposure and obesity among U.S. children and adolescents and to explore underlying mechanism mediated by serum sex steroid hormones in these associations.</p><p><strong>Methods: </strong>Data from the 2015-2016 National Health and Nutrition Examination Survey were used for the analysis. Generalized linear regression was used to investigate the association between detectable neonicotinoids and ten measures of obesity. The interaction effects of multiple neonicotinoids were determined by Chi-squared Automatic Interaction Detection method. Mediation analysis was used to assess potential mediators of sex steroid hormones, including testosterone (T), estradiol (E₂), T/E₂, sex hormone-binding globulin (SHBG), and free androgen index (FAI).</p><p><strong>Results: </strong>Clothianidin (β = -0.29, 95 % CI: -0.57, -0.01) and N-desmethyl-acetamiprid (β = -0.19, 95 % CI: -0.35, -0.03) were associated with reduced VFI z-score. After stratification, 5-hydroxy-imidacloprid was positively associated with the risk of general obesity in males (OR=2.24, 95 % CI: 1.20, 4.20) with a probability of 52.5 %. FAI mediated 15 % of the association between neonicotinoid exposure and reduced risk of obesity, and SHBG mediated 30 % of the association between neonicotinoid exposure and increased risk of obesity.</p><p><strong>Conclusion: </strong>Neonicotinoids showed associations with obesity, but the results were mixed and sex-specific. Sex steroid hormones may play a role in mediating the effects of neonicotinoids on obesity.</p>","PeriodicalId":303,"journal":{"name":"Ecotoxicology and Environmental Safety","volume":"289 ","pages":"117708"},"PeriodicalIF":6.2,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142963452","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Thiacloprid exposure disrupts the gut-liver axis and induces liver dysfunction in the Reeves' turtles (Mauremys reevesii).","authors":"Shuqin Lin, Yunjuan Xiao, Siyu Li, Liyan Tang, Haitao Shi, Meiling Hong, Li Ding","doi":"10.1016/j.ecoenv.2025.117710","DOIUrl":"10.1016/j.ecoenv.2025.117710","url":null,"abstract":"<p><p>As one of the neonicotinoid insecticides, thiacloprid (THI) is extensively used in agriculture and frequently detected in various aquatic environments, posing a potential threat to aquatic organisms. However, the effects of THI exposure on aquatic turtles remain unknown. In this study, we focused on investigating whether THI has a toxic effect on the gut-liver axis in aquatic turtles. The Reeves' turtles (Mauremys reevesii) were exposed to 0.0178 μM, 6 μM, and 60 μM THI for 5 consecutive weeks. The results revealed that THI altered the composition of intestinal flora, with a decrease in the relative abundance of Romboutsia, and an increase in Clostridium_sensu_stricto_1, Cetobacterium, Enterococcus. This disruption of the intestinal barrier led to an increase in lipopolysaccharide (LPS), THI, and other harmful substances entering the liver. Metabolomic and transcriptomic analyses indicated that metabolic dysregulation and differences in gene expression were concentrated in amino acid metabolism and lipid metabolism, ultimately resulting in severe liver damage and steatosis. Furthermore, elevated levels of liver function indicators, including aspartate aminotransferase (AST), alanine aminotransferase (ALT), alkaline phosphatase (ALP), total bile acid (TBA), and triglyceride (TG), were positively correlated with increased THI concentrations. Our findings demonstrate that THI impairs the intestinal barrier and causes liver dysfunction and damage in turtles, providing new insights into evaluating the toxic effects of thiacloprid on aquatic organisms.</p>","PeriodicalId":303,"journal":{"name":"Ecotoxicology and Environmental Safety","volume":"289 ","pages":"117710"},"PeriodicalIF":6.2,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142968959","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exploring the link between soil health and crop productivity.","authors":"Yingying Xing, Xiukang Wang, Adnan Mustafa","doi":"10.1016/j.ecoenv.2025.117703","DOIUrl":"10.1016/j.ecoenv.2025.117703","url":null,"abstract":"<p><p>Understanding the complex interactions of plants and soils in the face of global food security and environmental degradation challenges is critical to the future of sustainable agriculture. This review discusses the important link between soil health and crop productivity by providing and comprehensive assessment of soil properties and management methods. By examining the physical, chemical, and biological properties of soil, it uncovers the key limitations posed by the soil environment on crop growth. The review highlights how soil texture, nutrient availability, and moisture levels directly impact on root growth, water uptake, and nutrient use efficiencies, while also exploring how diverse cropping systems enhance soil ecology and biodiversity. By utilizing state-of-the-art bioinformatics, we offer an in-depth exploration of rhizosphere microbial communities, emphasizing the functions of phosphate-solubilizing and nitrogen-fixing bacteria in promoting vital nutrient cycles. The potential of using microbial fertilizers to increase crop resistance to disease and stress hold a major premise for future sustainability in agriculture. In this regard, this review highlights the long-term impacts of crop cultivation on soil microbial diversity, revealing intricate selection processes between crops and their microbial partners in shaping crop-soil-microbe interactions. In terms of soil management, practical nutrient management strategies are proposed based on soil testing, emphasizing the benefits of organic farming and conservation tillage for soil health. Modern precision agricultural tools and remote sensing technologies are encouraged to be refined for effective nutrient management. At the policy level, we evaluate international guidelines aimed at fostering agricultural sustainability, suggesting new research pathways for crop-soil dynamics and offering approaches for developing soil health indicators in the face of global environmental challenges.</p>","PeriodicalId":303,"journal":{"name":"Ecotoxicology and Environmental Safety","volume":"289 ","pages":"117703"},"PeriodicalIF":6.2,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142982012","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Transcriptome response in a marine copepod under multigenerational exposure to ocean warming and Ni at an environmentally realistic concentration.","authors":"Yunlei Zhang, Shiru Lin, Yaolu Niu, Xiaoping Zhou, Qingxian Lin","doi":"10.1016/j.ecoenv.2024.117613","DOIUrl":"10.1016/j.ecoenv.2024.117613","url":null,"abstract":"<p><p>Due to anthropogenic activities, coastal areas have been challenged with multi-stresses such as ocean warming and nickel (Ni) pollution. Currently, studies have concerned the combined effects of Ni and warming in marine organisms at the phenotypic level; however, the underlying molecular mechanisms are poorly known. In this study, a marine copepod Tigriopus japonicus was maintained under warming (+ 4℃) and an environmentally realistic level of Ni (20 μg/L) alone or combined for three generations (F0-F2). Transcriptome analysis was performed for the F2 individuals. We found that the gene transcripts of copepods were predominantly down-regulated after Ni and warming exposure. Based on the results of GO and KEGG analysis, chitin metabolism, detoxification, antioxidant, apoptosis, and energy metabolism were screened in this study. Among the above functions, the combined exposure enriched more differential expression genes and had a larger fold change compared to Ni exposure alone, suggesting that warming increased the negative effect of Ni on marine copepods from a molecular perspective. Specifically, the combined exposure exacerbated the down-regulation of defense, apoptosis, xenobiotic efflux, GSH system, and energy metabolism, as well as the up-regulation of detoxification and peroxidase system. Overall, this study indicates that both ocean warming and Ni pollution adversely affect the marine copepod T. japonicus from multigenerational transcriptome analysis, especially warming increased Ni toxicity to marine copepods, and our results also provide references to the mechanism concerning the effects of Ni and warming on marine copepods.</p>","PeriodicalId":303,"journal":{"name":"Ecotoxicology and Environmental Safety","volume":"289 ","pages":"117613"},"PeriodicalIF":6.2,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142982033","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Brodifacoum causes coagulopathy, hemorrhages, and mortality in rainbow trout (Oncorhynchus mykiss) at environmentally relevant hepatic residue concentrations.","authors":"Hannah Schmieg, Hermann Ferling, Karina Annika Bucher, Stefanie Jacob, Julia Regnery, Hannah Schrader, Julia Schwaiger, Anton Friesen","doi":"10.1016/j.ecoenv.2024.117629","DOIUrl":"10.1016/j.ecoenv.2024.117629","url":null,"abstract":"<p><p>Widely used second-generation anticoagulant rodenticides like brodifacoum are classified as persistent, bioaccumulative, and toxic. Widespread exposure of terrestrial and avian non-target species is well-known and recently hepatic anticoagulant rodenticide residues have been detected in wild fish. However, no sufficient data exist to interpret the effects of these findings on fish health. In order to assess the potential impact of rodenticide residues on fish, we exposed rainbow trout (Oncorhynchus mykiss) to brodifacoum-spiked feed. In a first experiment, individually kept trout (body weight ca. 200 g) were exposed to a single dose of brodifacoum and observed for 15 days. In a second experiment, fish (body weight ca. 330 g) were kept in groups and fed every 7 or 8 days with brodifacoum-spiked feed for up to 60 days. Sampling of trout every 15 days over the 60 days period allowed monitoring of brodifacoum concentrations in serum, liver, and muscle tissue, as well as occurring effects over the course of the experiment. In both experiments, brodifacoum doses of ≥ 75 µg/kg body weight caused prolonged or non-measurable blood coagulation times. Disturbed hemostasis led to hemorrhages and anemia with significantly decreased albumin levels. In the 60 days-experiment, brodifacoum doses ≥ 100 µg/kg body weight caused additionally discoloration, apathy, and anorexia, resulting in reduced weight gain, and ultimately mortality. The delay until the onset of overt symptoms (14-17 days) highlights the importance of test duration while investigating effects of anticoagulant rodenticides in fish. The lowest hepatic brodifacoum concentration associated with effects in trout was on average 122.6 ng/g liver wet weight, which is in the range of previously reported brodifacoum residues in wild fish. These findings illustrate the risks associated with the use of anticoagulant rodenticides for freshwater fish and reinforce the need to stipulate all available and appropriate risk mitigation measures to prevent emissions at source.</p>","PeriodicalId":303,"journal":{"name":"Ecotoxicology and Environmental Safety","volume":"289 ","pages":"117629"},"PeriodicalIF":6.2,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142982044","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Neurotrophin-3 as a mediator in the link between PM_2.5 exposure and psychiatric disorders: A Mendelian randomization study.","authors":"Yuan Zhang, Wei Wang, Xuening Zhang, Ran Jing, Xin Wen, Peng Xiao, Xinjie Liu, Zengle Zhao, Tongmin Chang, Yufei Li, Wen Liu, Chenxi Sun, Xiaorong Yang, Lejin Yang, Ming Lu","doi":"10.1016/j.ecoenv.2024.117658","DOIUrl":"10.1016/j.ecoenv.2024.117658","url":null,"abstract":"<p><strong>Background: </strong>The causal relationship between PM_2.5 (particulate matter with an aerodynamic diameter ≤2.5 μm) and common mental disorders, along with its neuropathological mechanisms, remains unclear.</p><p><strong>Methods: </strong>We used genome-wide association study datasets from the UK Biobank and Psychiatric Genomics Consortium to systematically investigate the causal relationship between PM_2.5 and nine common psychiatric disorders using two-sample Mendelian randomization (TSMR) methods. Subsequently, we used two-step MR to investigate the mediating effect of 108 potential mediators in the association between PM_2.5 and mental disorders.</p><p><strong>Results: </strong>Our findings indicated that PM_2.5 was positively associated with major depressive disorder (odds ratio (OR): 1.33, 95 % confidence interval (CI): 1.11-1.55), anxiety disorder (OR: 2.96, 95 % CI: 2.13-3.79), schizophrenia (OR: 1.55, 95 % CI: 1.29-1.81), and attention deficit hyperactivity disorder (ADHD) (OR: 1.95, 95 % CI: 1.66-2.24). Unexpectedly, PM_2.5 was inversely associated with bipolar disorder (OR: 0.65, 95 % CI: 0.37-0.93). Additionally, PM_2.5 was not significantly associated with autism spectrum disorders (OR: 1.24, 95 % CI: 0.83-1.65), post-traumatic stress disorder (OR: 1.51, 95 % CI: 1.11-1.91), obsessive-compulsive disorder (OR: 0.81, 95 % CI: -0.07-1.69), or anorexia nervosa (OR: 1.42, 95 % CI: 0.86-1.98). Further analysis using two-step MR revealed that Neurotrophin-3 mediated 9.86 % of the PM_2.5-ADHD association and 5.88 % of the PM_2.5-schizophrenia association. Sensitivity analyses supported these findings.</p><p><strong>Conclusions: </strong>This TSMR analysis provides a comprehensive examination of the causal relationship between PM_2.5 exposure and nine common psychiatric disorders, with mediation analysis offering insight into the underlying mechanisms. This study aims to raise public awareness of how air quality affects mental health through empirical evidence.</p>","PeriodicalId":303,"journal":{"name":"Ecotoxicology and Environmental Safety","volume":"289 ","pages":"117658"},"PeriodicalIF":6.2,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143031559","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exploring the mechanisms by which common inhalational anesthetics influence malignant tumor metastasis: A data mining study based on comparative toxicogenomic databases.","authors":"Yiyu Chen, Wenlan Ouyang, Hu Lv, Wei Chen","doi":"10.1016/j.ecoenv.2024.117660","DOIUrl":"10.1016/j.ecoenv.2024.117660","url":null,"abstract":"<p><p>Surgery remains the primary treatment for solid malignant tumors, but controlling postoperative tumor recurrence and metastasis continues to be a major challenge. Understanding the factors that influence tumor recurrence and metastasis after surgery, as well as the underlying biological mechanisms, is critical. Previous studies suggest that anesthetic agents may increase the risk of tumor recurrence and metastasis in patients with cancer, but the mechanisms underlying these findings remain unclear. In this study, we utilized toxicogenomics and comparative toxicogenomic databases to analyze data and explore the potential mechanisms by which three commonly used inhalational anesthetics-sevoflurane, isoflurane, and halothane-might promote malignant tumor metastasis. The results identified 18 genes that may be associated with tumor metastasis. Functional enrichment analysis revealed that these anesthetics could influence tumor cell migration by activating signaling pathways such as the IL-17 and tumor necrosis factor signaling pathways, thereby potentially inducing tumor metastasis. Moreover, by constructing a TF-mRNA network, we predicted several transcription factors that might play key roles in anesthetic-induced tumor metastasis. The analysis revealed a total of 87 regulatory relationships between transcription factors and mRNA. These findings offer new insights for future in vivo or in vitro studies and contribute to a better understanding of the relationship between inhalational anesthetics and tumor metastasis, providing valuable reference points for clinical decision-making. The results of this study also provide a reference for the determination of subsequent clinical treatment targets. Hence, future laboratory studies should prioritize investigating the specific genes and common mechanisms identified in this study.</p>","PeriodicalId":303,"journal":{"name":"Ecotoxicology and Environmental Safety","volume":"289 ","pages":"117660"},"PeriodicalIF":6.2,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143031839","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}