Ecotoxicology and Environmental Safety最新文献

{"title":"Global assessment of honeybee exposure to pesticides through guttation consumption: An indicator approach","authors":"Zijian Li","doi":"10.1016/j.ecoenv.2023.115581","DOIUrl":"10.1016/j.ecoenv.2023.115581","url":null,"abstract":"<div><p>Guttation consumption is a potential pathway of pesticide residue exposure in honeybees. However, modeling tools for assessing honeybee exposure to pesticide residues in guttation drops are lacking. In this study, we propose an indicator-based approach for qualitatively or quantitatively analyzing the guttation-based exposure pathway, allowing us to conduct region-specific pesticide residue exposure assessments for honeybees. Exposure scores (the product of guttation production and residue level scores) were established to compare or rank honeybee exposure to pesticide residues via guttation intake across locations using three specified indicators (i.e., air temperature, relative humidity, and precipitation intensity). Warm, dry regions had high residue level scores (indicating high residue levels in guttation), whereas cold, wet regions had high guttation production scores (indicating high possibilities of guttation formation on leaf surfaces); their exposure scores were a combination of these two values. We evaluated and ranked honeybee exposure to imidacloprid residue across regions in Brazil, China, the United States, and selected European Union member states, revealing that pesticide application in many Brazilian federative units may raise honeybee risks due to high exposure scores. We also compared the guttation pathway to other common exposure pathways (nectar and pollen), suggesting that for some moderately lipophilic compounds, the guttation exposure pathway may not be ignored and should be further evaluated.</p></div>","PeriodicalId":303,"journal":{"name":"Ecotoxicology and Environmental Safety","volume":"266 ","pages":"Article 115581"},"PeriodicalIF":6.8,"publicationDate":"2023-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S0147651323010850/pdfft?md5=a8a7754da259f1aebf4eceb8e8e31744&pid=1-s2.0-S0147651323010850-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41231016","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Quantitative relationship between soil pH and electrical conductivity values and cadmium phytoavailability for Chinese cabbage under simulated conditions","authors":"Zhuoyi Yan ,&nbsp;Wenchuan Ding ,&nbsp;Gengxin Xie ,&nbsp;Ming Yan ,&nbsp;Ya Han ,&nbsp;Xin Xiong","doi":"10.1016/j.ecoenv.2023.115566","DOIUrl":"10.1016/j.ecoenv.2023.115566","url":null,"abstract":"<div><p>Pot experiments were conducted to investigate the impacts of continuous addition of different concentrations of calcium chloride (CaCl₂) and/or low-molecular-weight organic acids (LMWOAs) on soil pH, electrical conductivity (EC), and cadmium (Cd) transformation. These factors subsequently affected Cd phytoavailability in a system consisting of Cd-contaminated soil and Chinese cabbage (<em>Brassica chinensis</em> L.). The results indicate that CaCl₂ addition had a greater impact on reducing soil pH value, increasing soil EC value, and enhancing Cd phytoaccumulation in Chinese cabbage compared to LMWOAs. When soil pH dropped by 0.3 unit and the soil EC increased by 500 µS cm⁻¹, the Cd concentration in the Chinese cabbage shoots was 3 times higher than that in the control group. Throughout two planting terms of Chinese cabbage, the addition of CaCl₂ (1.6–3.2 g kg⁻¹) and LMWOAs (≤ 1.0 g kg⁻¹) led to phytoextracted Cd concentration exceeding exchangeable Cd concentration in soil samples before the pot experiment. Regarding phytoextracted Cd, desorption from carbonate-bound Cd contributes more than desorption from bound to organic matter Cd and adsorption to Fe/Mn oxide Cd. This study underscores the influence of soil pH and EC value variations and Cd transformation on Cd phytoavailability. Special attention should be given to leafy vegetables grown in Cd-contaminated soil, as the phytoavailable Cd concentration reaches approximately 2.0 µg kg⁻¹, which may lead to Cd levels surpassing acceptable limits for Chinese cabbage.</p></div>","PeriodicalId":303,"journal":{"name":"Ecotoxicology and Environmental Safety","volume":"266 ","pages":"Article 115566"},"PeriodicalIF":6.8,"publicationDate":"2023-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S0147651323010709/pdfft?md5=508d8d7f6786d1fce91ec13a3a8f7974&pid=1-s2.0-S0147651323010709-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41231080","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Silica-exposed macrophages-secreted exosomal miR125a-5p induces Th1/Th2 and Treg/Th17 cell imbalance and promotes fibroblast transdifferentiation","authors":"Mingcui Ding ,&nbsp;Chengpeng Zhang ,&nbsp;Wei Wang ,&nbsp;Pengpeng Wang ,&nbsp;Yangqing Pei ,&nbsp;Na Wang ,&nbsp;Shan Huang ,&nbsp;Changfu Hao ,&nbsp;Wu Yao","doi":"10.1016/j.ecoenv.2023.115647","DOIUrl":"10.1016/j.ecoenv.2023.115647","url":null,"abstract":"<div><p>Until now, the specific pathogenesis of silicosis is not clear. Exosomal miRNAs, as a newly discovered intercellular communication medium, play an important role in many diseases. Our previous research found that serum exosomal miR125a-5p was increased in silicosis patients by miRNAs high-throughput sequencing. TRAF6, is a target gene of miR125a-5p, which is involved in T-cell differentiation. Furthermore, results from animal study indicate that knockdown of miR-125a-5p can regulate T lymphocyte subsets and significantly reduce pulmonary fibrosis by targeting TRAF6. However, the level of serum exosomal miR125a-5p in silicosis patients has not been reported, the role of macrophages-secreted exosomal miR-125a-5p in regulating T cell differentiation to promote fibroblast transdifferentiation (FMT) remains unknown. In this study, the levels of serum exosomal miR125a-5p and serum TGF-β1, IL-17A, IL-4 cytokines in silicosis patients were elevated, with the progression of silicosis, the level of serum exosomal miR125a-5p and serum IL-4 were increased; thus, the serum level of IFN-γ was negatively correlated with the progression of silicosis. <em>In vitro</em>, the levels of miR125a-5p in macrophages, exosomes, and T cells stimulated by silica were significantly increased. When the mimic was transfected into T cells, which directly suppressed TRAF6 and caused the imbalance of T cells differentiation, induced FMT. To sum up, these results indicate that exosomal miR-125a-5p may by targeting TRAF6 of T cells, induces the activation and apoptosis of T cells and the remodeling of Th1/Th2 and Th17/Tregs distribution, ultimately promotes FMT. Suggesting that exosomal miR-125a-5p may be a potential therapeutic target for silicosis.</p></div>","PeriodicalId":303,"journal":{"name":"Ecotoxicology and Environmental Safety","volume":"267 ","pages":"Article 115647"},"PeriodicalIF":6.8,"publicationDate":"2023-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S014765132301151X/pdfft?md5=a417732c27f4544051f295509b8fa608&pid=1-s2.0-S014765132301151X-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"71418982","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Biomarkers of oxidative stress, inflammation, and genotoxicity to assess exposure to micro- and nanoplastics. A literature review","authors":"Marco Panizzolo ,&nbsp;Vitor Hugo Martins ,&nbsp;Federica Ghelli ,&nbsp;Giulia Squillacioti ,&nbsp;Valeria Bellisario ,&nbsp;Giacomo Garzaro ,&nbsp;Davide Bosio ,&nbsp;Nicoletta Colombi ,&nbsp;Roberto Bono ,&nbsp;Enrico Bergamaschi","doi":"10.1016/j.ecoenv.2023.115645","DOIUrl":"10.1016/j.ecoenv.2023.115645","url":null,"abstract":"<div><p>The increased awareness about possible health effects arising from micro- and nanoplastics (MNPs) pollution is driving a huge amount of studies. Many international efforts are in place to better understand and characterize the hazard of MNPs present in the environment. The literature search was performed according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) methodology in two different databases (PubMed and Embase). The selection of articles was carried out blind, screening titles and abstracts according to inclusion and exclusion criteria. In general, these studies rely on the methodology already in use for assessing hazard from nanomaterials and particles of concern. However, only a limited number of studies have so far directly measured human exposure to MNPs and examined the relationship between such exposure and its impact on human health. This review aims to provide an overview of the current state of research on biomarkers of oxidative stress, inflammation, and genotoxicity that have been explored in relation to MNPs exposure, using human, cellular, animal, and plant models. Both in-vitro and in-vivo models suggest an increased level of oxidative stress and inflammation as the main mechanism of action (MOA) leading to adverse effects such as chronic inflammation, immunotoxicity and genotoxicity. With the identification of such biological endpoints, representing critical key initiating events (KIEs) towards adaptive or adverse outcomes, it is possible to identify a panel of surrogate biomarkers to be applied and validated especially in occupational settings, where higher levels of exposure may occur.</p></div>","PeriodicalId":303,"journal":{"name":"Ecotoxicology and Environmental Safety","volume":"267 ","pages":"Article 115645"},"PeriodicalIF":6.8,"publicationDate":"2023-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S0147651323011491/pdfft?md5=994a4b1d62c216dc44e5d22c254fbe62&pid=1-s2.0-S0147651323011491-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"71475049","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"N-doped citrate-sludge-derived carbon (NCSC) effectively promotes peroxymonosulfate activation for perfluorooctanoic acid (PFOA) removal with surface-mediated electron transfer mechanism","authors":"Shiyuan Fu ,&nbsp;Yi Zhang ,&nbsp;Xiangyang Xu ,&nbsp;Yingyu Tan ,&nbsp;Liang Zhu","doi":"10.1016/j.ecoenv.2023.115592","DOIUrl":"10.1016/j.ecoenv.2023.115592","url":null,"abstract":"<div><p>In traditional wastewater treatment methods, the removal of emerging contaminants including perfluorooctanoic acid (PFOA) can be challenging. To address this, biochar is commonly utilized as an activator for peroxymonosulphate (PMS) to effectively eliminate organic pollutants. Sewage sludge has shown potential as a biochar precursor, but its complex composition and variable iron content, as well as the low specific surface area of the product limit the practical use of iron-dominated sludge-derived catalysts. To overcome this limitation, N-doped citrate-sludge-derived carbon (NCSC) was synthesized, possessing a low iron content (0.29 at%) and a large specific surface area (315.31 m² g⁻¹). As a comparison, Fe-/N-doped citrate-sludge-derived carbon (Fe-NCSC) was prepared by introducing exogenous iron, resulting in a higher iron content (2.12 at%) but a significantly reduced specific surface area (73.87 m² g⁻¹). In performance evaluation, the NCSC/PMS system achieved impressive removal efficiency, effectively eliminating 99.8% of PFOA (at an initial concentration of 2 mg L⁻¹) within 60 min, while Fe-NCSC/PMS only achieved 84.6%. The slightly lower reaction rate per specific surface area of NCSC/PMS proved that large specific surface area was NCSC’s key advantage. The lower sensitivity of NCSC to pH and water substrates than FeNCSC suggested different activation mechanisms. Further analysis of reactive sites and species showed that the main oxidation mechanism of NCSC/PMS was forming the surface-bound PMS-NCSC complexes at the N sites, followed by PFOA donating electrons to the complexes to be oxidized, which was different from the Fe/N-dominated singlet oxygen mechanism of Fe-NSC/PMS. Furthermore, the reusability of the NCSC was demonstrated, with the removal rate decreasing to only 90.1% after four cycles and recovering to 94.8% after heated regeneration. In conclusion, this study provides a viable method for the elimination of emerging contaminants such as PFOA in water remediation.</p></div>","PeriodicalId":303,"journal":{"name":"Ecotoxicology and Environmental Safety","volume":"266 ","pages":"Article 115592"},"PeriodicalIF":6.8,"publicationDate":"2023-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S0147651323010965/pdfft?md5=371a50ace3f68dfa3a896406d054cf88&pid=1-s2.0-S0147651323010965-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41186911","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of co-applied biochar and plant growth-promoting bacteria on soil carbon mineralization and nutrient availability under two nitrogen addition rates","authors":"Yiping Zou ,&nbsp;Zhengfeng An ,&nbsp;Xinli Chen ,&nbsp;Xiang Zheng ,&nbsp;Ben Zhang ,&nbsp;Shuyue Zhang ,&nbsp;Scott X. Chang ,&nbsp;Jianli Jia","doi":"10.1016/j.ecoenv.2023.115579","DOIUrl":"10.1016/j.ecoenv.2023.115579","url":null,"abstract":"<div><p>In the background of climate warming, the demand for improving soil quality and carbon (C) sequestration is increasing. The application of biochar to soil has been considered as a method for mitigating climate change and enhancing soil fertility. However, it is uncertain whether the effects of biochar application on C-mineralization and N transformation are influenced by the presence or absence of plant growth-promoting bacteria (PGPB) and soil nitrogen (N) level. An incubation study was conducted to investigate whether the effects of biochar application (0 %, 1 %, 2 % and 4 % of soil mass) on soil respiration, N status, and microbial attributes were altered by the presence or absence of PGPB (i.e., <em>Sphingobium yanoikuyae</em> BJ1) under two soil N levels (N0 and N1 soils as created by the addition of 0 and 0.2 g kg⁻¹ urea- N, respectively). The results showed that biochar, BJ1 strain and their interactive effects on cumulative CO₂ emissions were not significant in N0 soils, while the effects of biochar on the cumulative CO₂ emissions were dependent on the presence or absence of BJ1 in N1 soils. In N1 soils, applying biochar at 2 % and 4 % increased the cumulative CO₂ emissions by 141.0 % and 166.9 %, respectively, when BJ1 was absent. However, applying biochar did not affect CO₂ emissions when BJ1 was present. In addition, the presence of BJ1 generally increased ammonium contents in N0 soils, but decreased nitrate contents in N1 soils relative to the absence of BJ1, which indicates that the combination of biochar and BJ1 is beneficial to play the N fixation function of BJ1 in N0 soils. Our results highlight that biochar addition influences not only soil C mineralization but also soil available N, and the direction and magnitude of these effects are highly dependent on the presence of PGPB and the soil N level.</p></div>","PeriodicalId":303,"journal":{"name":"Ecotoxicology and Environmental Safety","volume":"266 ","pages":"Article 115579"},"PeriodicalIF":6.8,"publicationDate":"2023-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S0147651323010837/pdfft?md5=2a51c22d478074410d90d89ce6582edb&pid=1-s2.0-S0147651323010837-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49672294","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Kaolinite reduced Cd accumulation in peanut and remediate soil contaminated with both microplastics and cadmium","authors":"Xin Song ,&nbsp;Jianpeng Jin ,&nbsp;Haiyun Li ,&nbsp;Fangli Wang ,&nbsp;Jun Liu ,&nbsp;Xuexia Wang ,&nbsp;Xiaoli Huang ,&nbsp;Chao Chai ,&nbsp;Ningning Song ,&nbsp;Haiying Zong","doi":"10.1016/j.ecoenv.2023.115580","DOIUrl":"10.1016/j.ecoenv.2023.115580","url":null,"abstract":"<div><p>Microplastics (MPs) increase the effective state of heavy metals (HMs) in soil and seriously threaten the yield and quality of peanuts (<em>Arachis Hypogea</em> L.). Kaolinite (KL) has the potential to ameliorate MP- and HM- contaminated soils, but the mechanism of action between them is not well understood. Therefore, 60-day experiments were conducted, where KL (1 %, 2 %) and MPs (0.1 %, 1 %) were individually or jointly mixed into soils with different cadmium (Cd) concentrations (0.5, 2.5, and 5.0 mg·kg⁻¹) to cultivate peanuts in a greenhouse. Finally, soil-bioavailable Cd, peanut dry weight, peanut Cd concentrations, the pH, cation exchange capacity (CEC), dissolved organic carbon (DOC), microbial biomass carbon (MBC) and microbial biomass nitrogen (MBN) were determined. It was shown that MPs negatively affected the peanut dry weight and increased the content of soil-bioavailable Cd and Cd concentration in peanut. In the MP- and Cd-contaminated soils, KL mitigated the negative influence of MPs by increasing the dry weight of peanuts by 8.40 %−40.59 %, decreasing the soil-bioavailable Cd by 23.70–35.74 %, and significantly decreasing peanut Cd concentrations by 9.65–30.86 %. The presence of MPs decreased soil pH (7.69–7.87) and the CEC (20.96–23.95 cmol·L⁻¹) and increased the soil DOC (1.84–2.26 mg·kg⁻¹). KL significantly increased soil pH (7.79–8.03) and the CEC (24.96–28.28 cmol·L⁻¹) and mitigated the adverse influence of MPs on the pH and CEC of Cd-contaminated soils. A regression path analysis (RPA) evidenced that KL decreased Cd accumulation in plants by changing the properties of soil contaminated with MPs and Cd. The research results revealed the mechanism of KL on peanut growth and Cd absorption in MP- and Cd-contaminated soil. The results of this study provide a foundation to improve the quality of MP- and HM-contaminated soils and realize safe peanut production.</p></div>","PeriodicalId":303,"journal":{"name":"Ecotoxicology and Environmental Safety","volume":"266 ","pages":"Article 115580"},"PeriodicalIF":6.8,"publicationDate":"2023-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S0147651323010849/pdfft?md5=93683f233892b19fefd4ee9fc5b5b040&pid=1-s2.0-S0147651323010849-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49672298","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sepiolite promotes photodegradation of pyrene under visible light","authors":"Gema Marcelo ,&nbsp;Pedro Rodríguez-Pascual ,&nbsp;Belen Batanero ,&nbsp;Francisco Mendicuti ,&nbsp;Carlos Pecharromán","doi":"10.1016/j.ecoenv.2023.115573","DOIUrl":"10.1016/j.ecoenv.2023.115573","url":null,"abstract":"<div><p>Mechanochemistry and photocatalysis are emergent technologies for the remediation of polycyclic aromatic hydrocarbons (PAHs) in soils. In this work, mechanochemistry and photocatalysis are combined for pyrene degradation. The photodegradation of pyrene, when in contact with sepiolite under pressure application, is studied. The mechanical treatment leads to a pyrene crystal phase transformation. In this new phase, pyrene undergoes a fast photodegradation in the 320–420 nm range. We show that sepiolite is superior as a photocatalyst in pyrene degradation to TiO₂, the most exploited photocatalyst. A broad physicochemical characterization is carried out to propose a mechanism in which the photoexcitation of mechanically altered pyrene leads to an electron transfer to sepiolite matrix, which triggers the PAH degradation. Finally, we want to highlight that the pyrene/sepiolite combination is a simplified system to shed light on how PAH photodegradation may occur in soils.</p></div>","PeriodicalId":303,"journal":{"name":"Ecotoxicology and Environmental Safety","volume":"266 ","pages":"Article 115573"},"PeriodicalIF":6.8,"publicationDate":"2023-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S0147651323010771/pdfft?md5=d1a476805e4ef4667410901880cb10d8&pid=1-s2.0-S0147651323010771-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49672302","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Carbonaceous adsorbents in the removal of aquaculture pollutants: A technical review of methods and mechanisms","authors":"Jessica H. Taylor,&nbsp;Salman Masoudi Soltani","doi":"10.1016/j.ecoenv.2023.115552","DOIUrl":"10.1016/j.ecoenv.2023.115552","url":null,"abstract":"<div><p>Carbonaceous adsorbents (CAs) are becoming increasingly popular owing to their low-cost, ease of preparation, and versatility. Meanwhile, aquaculture is becoming a fundamental food industry, globally, due to a wide range of advantages such as economic and nutritional benefits, whilst protecting the depletion of natural resources. However, as with any farming, the technique is known to introduce a plethora of chemicals into the surrounding environment, including antibiotics, nutrients, fertilisers and more. Therefore, the treatment of aquaculture effluent is gaining traction to ensure the sustainable growth of the industry. Although the existing mitigation techniques are somewhat effective, they suffer from degradation of the water quality or harm to local environments/organisms. This article aims to identify the sources and impacts of various aquaculture pollutants. After which the authors will provide an environmentally friendly and novel approach to the treatment of aquaculture effluent using carbonaceous adsorbents. The article will detail discussions about the product life span, including, synthesis, activation, modification, applications in aqueous media, regeneration and End-of-Life (EoL) approaches, with a particular focus on the impacts of competitive adsorption between pollutants and environmental matrices. Some research gaps were also highlighted, such as the lack of literature applying real-world samples, the effects of competitive adsorption and the EoL applications and management for CAs.</p></div>","PeriodicalId":303,"journal":{"name":"Ecotoxicology and Environmental Safety","volume":"266 ","pages":"Article 115552"},"PeriodicalIF":6.8,"publicationDate":"2023-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S0147651323010564/pdfft?md5=532d5e2eb5a8bef5d749ad02b5d2733e&pid=1-s2.0-S0147651323010564-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41181532","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exposure to echimidine impairs the heart development and function of zebrafish larvae","authors":"Tingting Lin ,&nbsp;Li Zhou ,&nbsp;Zhibin Chen ,&nbsp;Luanjin Wang ,&nbsp;Jian Yang ,&nbsp;Sheng Wang ,&nbsp;Xintan Chen ,&nbsp;Zhenghong Zuo ,&nbsp;Chengyong He ,&nbsp;Lanping Guo","doi":"10.1016/j.ecoenv.2023.115574","DOIUrl":"10.1016/j.ecoenv.2023.115574","url":null,"abstract":"<div><p>Pyrrolizidine alkaloids (PAs) are a class of phytotoxins that are widely distributed and can be consumed by humans through their daily diets. Echimidine is one of the most abundant PAs, but its safety, particularly its effects on development, is not fully understood. In this study, we used a zebrafish model to assess the developmental toxicity of echimidine. Zebrafish embryos were exposed to echimidine at concentrations of 0.02, 0.2, and 2 mg/L for 96 h. Our study revealed that embryonic exposure to echimidine led to developmental toxicity, characterized by delayed hatching and reduced body length. Additionally, echimidine exposure had a notable impact on heart development in larvae, causing tachycardia and reducing stroke volume (SV)and cardiac output (CO). Upon exposing the transgenic zebrafish strain <em>Tg</em>(<em>cmlc2:EGFP</em>) to echimidine, we observed atrial dilation and thinning of the atrial wall in developing embryos. Moreover, our findings indicated abnormal expression of genes associated with cardiac development (including <em>gata4</em>, <em>tbx5</em>, <em>nkx2.5</em> and <em>myh6</em>) and genes involved in calcium signaling pathways (such as <em>cacna1aa</em>, <em>cacna1sa</em>, <em>ryr2a</em>, <em>ryr2b</em>, <em>atp2a2a</em>, <em>atp2a2b</em>, <em>slc8a1</em>, <em>slc8a3</em> and <em>slc8a4a</em>). In summary, our findings demonstrate that echimidine may impair cardiac development and function in zebrafish larvae by disrupting calcium transport, leading to developmental toxicity. These findings provide insights regarding the safety of products containing PAs in food and medicine.</p></div>","PeriodicalId":303,"journal":{"name":"Ecotoxicology and Environmental Safety","volume":"266 ","pages":"Article 115574"},"PeriodicalIF":6.8,"publicationDate":"2023-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S0147651323010783/pdfft?md5=918d2a7fb889c6419b02b99beeaf7888&pid=1-s2.0-S0147651323010783-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41231015","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}