Ecotoxicology and Environmental Safety最新文献

{"title":"The association between air pollution and three types of diabetes: An umbrella review of systematic reviews and meta-analyses","authors":"Weicong Jiang ,&nbsp;Huili Zhou ,&nbsp;Guangbiao Xu ,&nbsp;Meixian Zhang ,&nbsp;Tao-Hsin Tung ,&nbsp;Chengwen Luo","doi":"10.1016/j.ecoenv.2025.118080","DOIUrl":"10.1016/j.ecoenv.2025.118080","url":null,"abstract":"<div><h3>Background</h3><div>Despite numerous meta-analyses showing an association between air pollutants and diabetes, there is considerable heterogeneity between studies.</div></div><div><h3>Objectives</h3><div>This study aims to evaluate the cumulative evidence regarding the association between air pollution and type 1 diabetes mellitus (T1DM), type 2 diabetes mellitus (T2DM), and gestational diabetes mellitus (GDM) through systematic reviews and meta-analyses.</div></div><div><h3>Methods</h3><div>Following the PRISMA 2020 guidance, a comprehensive review across three databases, including Web of Science, Embase, and PubMed, from inception to September 30, 2024. The quality of the included systematic reviews was assessed using the AMSTAR 2 tool. The research protocol has been registered in PROSPERO (CRD42024594953).</div></div><div><h3>Results</h3><div>A total of 19 meta-analyses were identified in this review, including two articles investigating the impact of air pollution on T1DM, nine on T2DM, and ten on GDM. Due to limited data, no significant relationship between air pollution and T1DM was found. There is evidence that exposure to particulate matter (PM_2.5 and PM₁₀) may significantly increase the risk of T2DM. However, meta-analyses concerning GDM exhibit a less consistent association between air pollution and GDM risk, which varies by pollutant and duration of exposure.</div></div><div><h3>Conclusion</h3><div>Results suggest that exposure to air pollution may increase diabetes risk to some extent, particularly for T2DM. However, due to limited available studies, further prospective cohort studies are warranted to elucidate the role of air pollutants in diabetes, particularly for T1DM. Additionally, understanding potential mechanisms by which air pollution affects diabetes is crucial for future investigations.</div></div>","PeriodicalId":303,"journal":{"name":"Ecotoxicology and Environmental Safety","volume":"294 ","pages":"Article 118080"},"PeriodicalIF":6.2,"publicationDate":"2025-03-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143673141","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exploring comprehensive toxic effects of fludioxonil on Caenorhabditis elegans","authors":"Sooji Choi,&nbsp;Eunyoung Jun,&nbsp;Yuri Lee,&nbsp;Kyung Won Kim","doi":"10.1016/j.ecoenv.2025.117996","DOIUrl":"10.1016/j.ecoenv.2025.117996","url":null,"abstract":"<div><div>Fludioxonil is a phenylpyrrole fungicide widely used in agriculture. Despite its efficacy against target fungi, there have been concerns raised regarding the potential adverse effects on non-target organisms. This study assesses its toxicity effects on <em>Caenorhabditis elegans</em> (<em>C. elegans</em>) across physiological, cellular, neuronal, and behavioral dimensions. At the physiological level, fludioxonil significantly reduces the growth, lifespan, and reproductive capacity of <em>C. elegans</em>, indicating disruptive effects on overall organismal health. At the cellular level, fludioxonil elevates reactive oxygen species (ROS), which can result in oxidative stress. At the neuronal level, fludioxonil induces dopaminergic neurodegeneration and upregulates critical neurotransmission genes <em>dat-1</em> and <em>unc-47</em>, which affects the nervous system. At the behavioral level, <em>C. elegans</em> exposed to fludioxonil exhibits increased locomotion and abnormal behaviors. These findings collectively demonstrate that fludioxonil exerts multifaceted toxic effects on non-target organisms, challenging the assumption of its safety and suggesting significant implications for ecosystem health and safety regulations.</div></div>","PeriodicalId":303,"journal":{"name":"Ecotoxicology and Environmental Safety","volume":"294 ","pages":"Article 117996"},"PeriodicalIF":6.2,"publicationDate":"2025-03-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143673154","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Growth and physiological responses of spearmint (Mentha spicata) cuttings to norfloxacin","authors":"Jiehe Zhang ,&nbsp;Jiahui Jiang ,&nbsp;Yi Yang ,&nbsp;Tongtong Wu ,&nbsp;Xiangxiang Su ,&nbsp;Haisheng Tao","doi":"10.1016/j.ecoenv.2025.118058","DOIUrl":"10.1016/j.ecoenv.2025.118058","url":null,"abstract":"<div><div>The increasing global consumption of antibiotics is a growing concern for the scientific community since the residues discharged into the environment can accumulate in plants and affect their growth. <em>Mentha spicata</em> L. is commonly used as a spice and widely cultivated as a medicinal and edible crop under controlled environments. Our study aimed to assess the subacute toxicity of norfloxacin (NOR; 0, 5, 10, 20, and 40 mg/L) on <em>M. spicata</em> cuttings and investigate the degradation of NOR in hydroponics during a 14-day exposure under natural conditions. In response to NOR, there were concentration-dependent declines in biomass, chlorophyll <em>a</em>, root activity, root elongation, and obvious chlorosis. An increase in malondialdehyde content and antioxidant activity indicated that NOR exposure specifically led to oxidative stress. There was a slight rise in osmotic regulatory substances observed in the setups treated with NOR compared to the control group. Simultaneously, <em>M. spicata</em> also made a response to the stress of NOR, and phytodegradation plays a more significant role in the degradation of NOR, in addition to hydrolysis and photodegradation processes. The integrated biomarker responses vesion 2 index values gradually increased with rising exposure concentrations, which suggested that NOR had toxic effects on <em>M. spicata</em>. These findings will improve the understanding of fluoroquinolones antibiotic effects on plants.</div></div>","PeriodicalId":303,"journal":{"name":"Ecotoxicology and Environmental Safety","volume":"294 ","pages":"Article 118058"},"PeriodicalIF":6.2,"publicationDate":"2025-03-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143644467","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Improved effect of antibiotic treatments on the hippocampal spatial memory dysfunction of mice induced by high fluoride exposure: Insight from assembly processes and co-occurrence networks of gut microbial community","authors":"Ning Sun ,&nbsp;Jinge Xin ,&nbsp;Zhifang Zhao ,&nbsp;Yu Chen ,&nbsp;Baoxing Gan ,&nbsp;Lixiao Duan ,&nbsp;Jiuyang Luo ,&nbsp;Dandan Wang ,&nbsp;Yan Zeng ,&nbsp;Kangcheng Pan ,&nbsp;Bo Jing ,&nbsp;Dong Zeng ,&nbsp;Hailin Ma ,&nbsp;Hesong Wang ,&nbsp;Xueqin Ni","doi":"10.1016/j.ecoenv.2025.118048","DOIUrl":"10.1016/j.ecoenv.2025.118048","url":null,"abstract":"<div><div>High fluoride exposure was widely demonstrated to be related with brain memory impairment. Since the absorption of F^- enters the body mainly through the gastrointestinal tract, studying the effects of excessive intake of fluoride on brain memory function in various gut microbiome states might have profound implications for the prevention of fluorosis because growing evidence revealed the significance of the “microbiota-gut-brain” axis (MGBA). In the present study, we aimed to illustrate the potential mechanism of gut microbiota on high fluoride exposure-induced hippocampal lesions and spatial memory dysfunction in mice by the various intestinal microecological environments, which were constructed by antibiotic treatment. Mice fed with normal (CG1 and Exp1 groups) or sodium-fluoride (CG2 and Exp2 groups; 24 mg/kg sodium fluoride per mouse) by gavage administration with or without antibiotic treatments, a combination of metronidazole (1 g/L) and ciprofloxacin (0.2 g/L) in drinking water. Mice gavaged with excessive sodium fluoride alone exhibited reduced weight gain, hippocampal tissue damages, spatial memory levels dysfunction, impaired intestinal permeability, decreased inflammatory cytokines expression and antioxidant capability in the hippocampal and ileal tissues. In contrast, antibiotic intervention significantly reversed these high fluoride exposure-induced hippocampal and ileal changes.16S rRNA high throughput sequencing found that ileal microbiota were dominated by abundant taxa, which is conducive to constructing microbial interaction networks and module communities, and identifying keystone species targeted by high fluoride exposure compared with colonic microbiome. In addition, the microbial community composition and assembly mechanism of ileal microbiome under the effects of antibiotics were suitable for revealing the characteristics of high fluoride environment. In the later analysis, <em>Lactobacillus</em>, <em>Staphylococcus, Muribaculaceae</em> and <em>Robinsoniella</em> were considered as the keystone species targeted by high fluoride-exposed mice based on the analysis of network node properties and niche overlap of ileal microbes. Spearman rank correlation demonstrated that these keystone species had significant effects on hippocampal memory levels and intestinal health, as well as microbial communities functions. Compared to previous researches, this study further revealed intestinal microbial coummunity mediated the underlying mechanism through antibiotic treatment against high fluoride-induce hippocampal spatial memory impairment.</div></div>","PeriodicalId":303,"journal":{"name":"Ecotoxicology and Environmental Safety","volume":"294 ","pages":"Article 118048"},"PeriodicalIF":6.2,"publicationDate":"2025-03-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143668802","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mechanisms of reduced efficacy of HER2-targeted therapy in HER2-low breast cancer by long-term nicotine exposure in patient-derived xenograft mouse tumor models","authors":"Yu-Hsuan Lin ,&nbsp;Yuan-Soon Ho ,&nbsp;Bu-Miin Huang ,&nbsp;You-Cheng Liao ,&nbsp;Tzu-Chun Cheng ,&nbsp;Ying-Chi Lin ,&nbsp;Shih-Hsin Tu ,&nbsp;Yun Yen ,&nbsp;Li-Ching Chen","doi":"10.1016/j.ecoenv.2025.118071","DOIUrl":"10.1016/j.ecoenv.2025.118071","url":null,"abstract":"<div><div>The effects of long-term nicotine exposure on the treatment of HER2-positive breast cancer have only been studied epidemiologically, leaving the molecular mechanisms unclear. Therefore, it's challenging for clinicians to devise effective treatments based on this correlation. Our investigation explores the effects of prolonged nicotine exposure on the interaction between α9-nAChR and HER2 in HER2-positive breast cancer cells, highlighting its impact on anti-HER2 drug therapy efficacy. We used fluorescence resonance energy transfer (FRET) analysis to compare HER2 + tumor samples from smokers and non-smokers, finding a more vital interaction between α9-nAChR and HER2 in non-smoker's breast tumor tissues. A simulated study on the breast cancer patient-derived xenograft (PDX) tumor mouse model (n = 6 per group) revealed that long-term nicotine exposure significantly reduced this interaction compared to controls. Due to the poorer response of low HER2 tumors to trastuzumab in clinical practice, most patients require combination chemotherapy and have a worse prognosis. Therefore, this study chose HER2-low PDX models to simulate nicotine exposure and explore treatment strategies. Mice subjected to prolonged nicotine exposure exhibited faster tumor growth and reduced trastuzumab efficacy compared to controls (*p &lt; 0.05). Our results demonstrate that extended nicotine exposure weakens α9-nAChR and HER2 interaction, reducing the effectiveness of HER2-targeted therapy, fostering drug resistance, and underscoring the carcinogenic risks of nicotine.</div></div>","PeriodicalId":303,"journal":{"name":"Ecotoxicology and Environmental Safety","volume":"294 ","pages":"Article 118071"},"PeriodicalIF":6.2,"publicationDate":"2025-03-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143668823","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Microplastics in freshwater and marine ecosystems: Occurrence, characterization, sources, distribution dynamics, fate, transport processes, potential mitigation strategies, and policy interventions","authors":"Toheeb Lekan Jolaosho ,&nbsp;Mariam Folashade Rasaq ,&nbsp;Eniola Victoria Omotoye ,&nbsp;Oluwadamilola Victoria Araomo ,&nbsp;Opeyemi Shakirat Adekoya ,&nbsp;Opeyemi Yusuf Abolaji ,&nbsp;Jesuyon Joseph Hungbo","doi":"10.1016/j.ecoenv.2025.118036","DOIUrl":"10.1016/j.ecoenv.2025.118036","url":null,"abstract":"<div><div>Most of the literature on microplastics (MPs) focuses on freshwater or terrestrial ecosystems, frequently overlooking their interconnections with the marine environments. This oversight is worrying given that both ecosystems serve as primary pathways for the introduction of MPs into marine environments. This review synthesizes existing literature on MPs in both freshwater and marine ecosystems across all six continents. The most commonly produced plastic polymers in industry are polyethylene (36 %) and polypropylene (21 %), and studies revealed that these two materials are the most abundant in aquatic ecosystems. Primary and secondary MPs originate from a range of sources including land-based disposal, the ocean, airborne deposition, wastewater treatment facilities, automobiles, pharmaceuticals and personal care products, synthetic textiles, and insect repellents. Notably, secondary MPs, which are formed from the breakdown of larger plastic items comprise approximately 69–81% of marine debris, especially in urbanized, densely populated areas. The inconsistencies of the methodologies (sampling, extraction, and quantification) and the units employed for result presentations are part of the major limitations in MPs research. Environmental phenomena such as heteroaggregation, weathering, adsorption, leaching, and fragmentation are the major factors influencing the behavior, fate, and degradation process of plastic particles. The physicochemical properties of plastic polymers, such as density, crystallinity, as well as bioturbation, meteorological forces, and wind actions, including currents, waves, and tides, are responsible for biofouling, aggregation, sinking into the bottom sediment, resuspension, and the vertical, horizontal, and spatiotemporal distributions and transport of MPs. The potential solutions to mitigate plastic pollution are grounded in the 3Rs framework, which includes reducing production and consumption, advancing the biotechnological, chemical and microbial development of degradable polymers, promoting reusable plastic products with lower environmental impacts over their lifetimes, and recycling waste into new products. The regulatory policies on single-use plastics commonly involve permanent bans and financial penalties for violators. In addition, nations such as the United States, the Netherlands, and northern Europe have introduced economic incentives to encourage the return of reusable materials to reduce plastic waste and the resulting envrionmental pollution.</div></div>","PeriodicalId":303,"journal":{"name":"Ecotoxicology and Environmental Safety","volume":"294 ","pages":"Article 118036"},"PeriodicalIF":6.2,"publicationDate":"2025-03-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143642397","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Metagenomic assembled genomes profile potential pathogens and antibiotic-resistant pathogens in an urban river","authors":"Ting Zhang ,&nbsp;Shuqing Zhou ,&nbsp;Chunyan Cheng,&nbsp;Yang Yang,&nbsp;Dong Yang,&nbsp;Danyang Shi,&nbsp;Haibei Li,&nbsp;Zhongwei Yang,&nbsp;Tianjiao Chen,&nbsp;Junwen Li,&nbsp;Min Jin","doi":"10.1016/j.ecoenv.2025.118063","DOIUrl":"10.1016/j.ecoenv.2025.118063","url":null,"abstract":"<div><div>The microbiological safety of urban rivers that flow through cities is crucial to local public health. However, detailed insights into the key characteristics of pathogens in urban rivers remain limited due to the lack of efficient high-throughput analysis tools. In this study, a comprehensive profiling of potential pathogens, antibiotic-resistant pathogens (ARPs), and multidrug-resistant pathogens (MDRPs) in the Hai River, which runs through the central city of Tianjin, was conducted using metagenomic assembled genome (MAG) analysis. Of the 436 recovered MAGs assigned to 430 species, 110 MAGs were identified as potential pathogens due to the presence of virulence factors (VFs), whereas 19 MAGs containing both antibiotic resistance genes (ARGs) and VFs, were classified as potential ARPs, predominantly belonging to the genera <em>Kluyvera</em>, <em>Enterobacter,</em> and <em>Klebsiella</em>. Notably, nine species of MDRPs, including <em>Enterobacter kobei</em>, <em>Klebsiella pneumoniae</em>, <em>Morganella morganii</em>, <em>Kluyvera intermedia</em>, <em>Aeromonas salmonicida</em>, <em>Rahnella aceris</em>, <em>Hafnia paralvei</em>, the unidentified species Sep. D_bin46, and <em>Vibrio cholerae</em>, exhibited resistance to multidrug, beta-lactam, polymyxin, bacitracin, tetracycline, other peptide antibiotics, macrolide-lincosamide-streptogramin, aminoglycoside, and chloramphenicol. The unknown pathogen Sep. D_bin46, classified under <em>Aeromonas,</em> showed resistance to both carbapenems and polymyxins. The strong co-occurrence of ARGs, VFs, and mobile genetic elements suggests a significant risk of ARGs and VFs transfers among MDRPs with last-resort ARGs (<em>r</em> &gt; 0.8; <em>p</em> &lt; 0.05). Interestingly, the sampling location significantly influenced the presence of pathogens, ARPs, and MDRPs carrying last-resort ARGs in the water. Notably, their abundance was lower downstream of the Hai River compared to upstream. This observation suggests that urban environmental sanitation facilities may be more effective in reducing contaminants as the river flows from upstream to downstream. Nevertheless, the presence of pathogens, ARPs, and MDRPs with last-resort ARGs in the water underscores the ongoing microbiological risks associated with urban surface water.</div></div>","PeriodicalId":303,"journal":{"name":"Ecotoxicology and Environmental Safety","volume":"294 ","pages":"Article 118063"},"PeriodicalIF":6.2,"publicationDate":"2025-03-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143644468","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Simulating the effects of drip and flood irrigation on the leaching, migration, and redistribution of heavy metals in contaminated soil","authors":"Muyesaier Tudi ,&nbsp;Linsheng Yang ,&nbsp;Li Wang ,&nbsp;Binggan Wei ,&nbsp;Lijuan Gu ,&nbsp;Jiangping Yu ,&nbsp;Hairong Li ,&nbsp;Yuan Xue ,&nbsp;Fang Wang ,&nbsp;Linfeng Li ,&nbsp;Qiming Jimmy Yu ,&nbsp;Huada Daniel Ruan ,&nbsp;Des Connell","doi":"10.1016/j.ecoenv.2025.118057","DOIUrl":"10.1016/j.ecoenv.2025.118057","url":null,"abstract":"<div><h3>Background</h3><div>The extensive adoption of drip irrigation globally has adverse effects on the ecological integrity of soil, leading to significant changes in the distribution of heavy metals and other pollutants across various soil layers. However, the mechanisms underlying such changes are still unclear.</div></div><div><h3>Purpose</h3><div>This study explores the effects of different irrigation methods (drip and flood irrigation) on the heavy metal behaviors in contaminated soils, including leaching, migration, and redistribution within agricultural practices.</div></div><div><h3>Materials and methods</h3><div>The soil column leaching experiments simulating drip and flood irrigation were performed. The correlation tests and one-way analysis of variance were used for data analysis.</div></div><div><h3>Results</h3><div>Compared to flood irrigation, drip irrigation resulted in higher leaching; as high as twice of heavy metal redistribution across soil columns. The average changes in heavy metal concentration before and after drip irrigation and flood irrigation were 16.3 % and 3.3 %, respectively. The soil redox potential and contact time were the main factors affecting the migration of heavy metals during the initial stages of irrigation implementation; however, hydrodynamic factors were also influential.</div></div><div><h3>Conclusion</h3><div>Drip irrigation may pose a serious threat to food safety in the areas with considerable heavy metal pollution due to increased heavy metal leaching and the accumulation of heavy metals near the soil surface, in particular at lower water volume.</div></div>","PeriodicalId":303,"journal":{"name":"Ecotoxicology and Environmental Safety","volume":"294 ","pages":"Article 118057"},"PeriodicalIF":6.2,"publicationDate":"2025-03-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143644466","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Associations of long-term joint exposure to multiple ambient air pollutants with the incidence of age-related eye diseases","authors":"Yingan Li ,&nbsp;Yuzhou Zhang ,&nbsp;Ka Wai Kam ,&nbsp;Poemen Chan ,&nbsp;Dong Liu ,&nbsp;Ebenezer Zaabaar ,&nbsp;Xiu Juan Zhang ,&nbsp;Mary Ho ,&nbsp;Mandy PH Ng ,&nbsp;Patrick Ip ,&nbsp;Alvin Young ,&nbsp;Chi Pui Pang ,&nbsp;Clement C. Tham ,&nbsp;Mei Po Kwan ,&nbsp;Li Jia Chen ,&nbsp;Jason C. Yam","doi":"10.1016/j.ecoenv.2025.118052","DOIUrl":"10.1016/j.ecoenv.2025.118052","url":null,"abstract":"<div><h3>Objectives</h3><div>The associations between long-term joint exposure to low levels of multiple air pollutants and the incidence of common age-related eye diseases (AREDs), including cataract, glaucoma, and age-related macular degeneration (AMD), remain underexplored.</div></div><div><h3>Methods</h3><div>We conducted a prospective cohort study using UK Biobank data from 441,567 participants without cataract, glaucoma, or AMD at baseline. An air pollution score was constructed to assess the combined effect of multiple air pollutants, including PM_2.5, PM_2.5–10, PM₁₀, NO₂ and NO. Cox proportional hazards models were used to evaluate associations.</div></div><div><h3>Results</h3><div>Over a median follow-up of 14.41 years, 55,104 participants developed cataract, 11,940 glaucoma, and 9060 AMD. A relatively stronger association was observed between combined exposure to multiple pollutants and AREDs incidence compared to exposure to individual pollutants. For every interquartile range increase in the air pollution score, the risk of incident AREDs increased by 4–5 % (cataract, HR [95 % CI], 1.05 [1.04–1.06]; glaucoma, 1.04 [1.02, 1.06]; AMD, 1.04 [1.01, 1.07]), suggesting the potential additive or synergistic effects of exposure to pollutant mixtures. Compared to individuals in the lowest exposure quartile, those in the highest had a 13 %, 9 %, and 14 % greater risk of developing cataract (1.13 [1.10–1.16]), glaucoma (1.09 [1.03–1.15]), and AMD (1.14 [1.07–1.22]), respectively.</div></div><div><h3>Conclusions</h3><div>Long-term joint exposure to multiple air pollutants, even at low concentrations, is associated with an increased risk of AREDs incidence, suggesting that reducing air pollution level could improve human ocular health. These findings provide a more comprehensive understanding of air pollution’s impact on ocular health in the real world.</div></div>","PeriodicalId":303,"journal":{"name":"Ecotoxicology and Environmental Safety","volume":"294 ","pages":"Article 118052"},"PeriodicalIF":6.2,"publicationDate":"2025-03-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143644465","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Gestational exposure to polystyrene microplastics incurred placental damage in mice: Insights into metabolic and gene expression disorders","authors":"Zhe Wang ,&nbsp;Runyan Shi ,&nbsp;Ruimin Wang ,&nbsp;Zhenzhu Ma ,&nbsp;Shuo Jiang ,&nbsp;Fengquan Zhang ,&nbsp;Weidong Wu","doi":"10.1016/j.ecoenv.2025.118056","DOIUrl":"10.1016/j.ecoenv.2025.118056","url":null,"abstract":"<div><div>As an emerging environmental pollutant, microplastics have attracted increasing attention to their potential health hazards. However, the current understanding about the toxicity and health implications, especially about developmental toxicity with exposure to microplastics is quite limited. In the current study, we aimed to scrutinize the deleterious effects of polystyrene microplastics (PSMPs) with different sizes (0.1 and 5 μm) on the placenta that plays crucial role in fetal development, following oral exposure during gestational stages. The results showed that two sizes of PSMPs could distribute in mouse placental tissues, and nanosized PSMPs (0.1 μm) exhibited greater capability to penetrate the placenta and deposit in the liver and brain of fetuses than microsized PSMPs (5 μm). Importantly, only 0.1 μm PSMPs induced a decrease in the junctional area, a reduction in the labyrinthine vascularization and an increase in cell apoptosis in the placenta, accompanied by fetal developmental impairments. The results of metabolome and transcriptome uncovered that 0.1 μm PSMP exposure caused changes in metabolic and gene profiles of placental tissues, across multiple pathways such as vascular supply, nutrient absorption and transportation and amino acid metabolism. Overall, our results confirmed that maternal PSMP exposure led to placental damages associated with metabolic and gene expression disorders. This study would provide new insights into the developmental impacts of microplastic consumption during gestation.</div></div>","PeriodicalId":303,"journal":{"name":"Ecotoxicology and Environmental Safety","volume":"294 ","pages":"Article 118056"},"PeriodicalIF":6.2,"publicationDate":"2025-03-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143644469","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}