The mediating role of gut microbiota in the influence of PM2.5 exposure on gestational diabetes mellitus

IF 6.1 2区环境科学与生态学 Q1 ENVIRONMENTAL SCIENCES

Ecotoxicology and Environmental Safety Pub Date : 2025-09-18 DOI:10.1016/j.ecoenv.2025.119070

Yan Long , Weitao Ye , Xueqing Cen , Hongmei Jin , Shanshan Mei , Jingyi Ye , Xueqin Zhao , Xiaoyan Zhang , Xiaoli Gao , Chunyan Zhu

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引用次数: 0

Abstract

Objective

Our study aimed to explore the mediating effects of the gut microbiota on the associations of PM_2.5 exposure with gestational diabetes mellitus (GDM).

Methods

Participants (n = 1268) were recruited in Guangzhou, China. The participants’ information and fecal samples were collected, the air pollutants exposures during pregnancy was assessed using measurements from the nearest monitoring station, and the relative abundance of fecal microbiota was characterized by 16S rRNA sequencing. Linear discriminant, mediation, and regression analyses were conducted to estimate the associations among PM_2.5 exposure, gut microbiota and GDM.

Results

Elevated PM_2.5 exposure was significantly correlated with the alterations in the gut microbiota, and with the increased risks of GDM and impaired glucose homeostasis. The mediation analyses indicated that alterations in the gut microbiota partially mediated the effects of PM_2.5 exposure on GDM and impaired glucose homeostasis. The total effects of PM_2.5 on GDM were mediated by g-Phascolarctobacterium (1.83 %), s-Phascolarctobacterium_unclassified (1.83 %), and s-Bacteroides_uniformis (0.65 %). The corresponding mediating effects for increased fasting glucose level were 3.48 %, 8.55 %, 1.76 %, 5.14 % and 0.02 % by g-Bacteroides, g-Lachnospiraceae_Ruminococcus, g-Streptococcus, g-Dorea and s-Bacteroides_uniformis, respectively.

Conclusions

Elevated PM_2.5 exposure from 3 months before pregnancy to the 12th week of gestation may induce GDM via alteration of the gut microbiota.

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肠道菌群在PM2.5暴露对妊娠期糖尿病影响中的中介作用。

目的：探讨肠道菌群在PM2.5暴露与妊娠期糖尿病（GDM）之间的中介作用。方法：在中国广州招募参与者（n = 1268）。收集参与者的信息和粪便样本，利用最近监测站的测量值评估怀孕期间的空气污染物暴露，并通过16S rRNA测序表征粪便微生物群的相对丰度。通过线性判别、中介和回归分析来估计PM2.5暴露、肠道微生物群和GDM之间的关系。结果：PM2.5暴露水平升高与肠道菌群改变、GDM风险增加和葡萄糖稳态受损显著相关。中介分析表明，肠道菌群的改变在一定程度上介导了PM2.5暴露对GDM和葡萄糖稳态受损的影响。PM2.5对GDM的总影响由g-Phascolarctobacterium（1.83 %）、s-Phascolarctobacterium_unclassified（1.83 %）和s-Bacteroides_uniformis（0.65 %）介导。g-Bacteroides、g- lachnospirace_ruminococcus、g-Streptococcus、g-Dorea和s-Bacteroides_uniformis对空腹血糖升高的调节作用分别为3.48 %、8.55 %、1.76 %、5.14 %和0.02 %。结论：妊娠前3个月至妊娠第12周PM2.5暴露升高可能通过改变肠道菌群诱发GDM。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Ecotoxicology and Environmental Safety 环境科学-毒理学

CiteScore

12.10

自引率

5.90%

发文量

1234

审稿时长

88 days

期刊介绍： Ecotoxicology and Environmental Safety is a multi-disciplinary journal that focuses on understanding the exposure and effects of environmental contamination on organisms including human health. The scope of the journal covers three main themes. The topics within these themes, indicated below, include (but are not limited to) the following: Ecotoxicology、Environmental Chemistry、Environmental Safety etc.