Exploring the associations between prenatal PCB exposures and gene expression: Observations from a study of newborn Slovak infants

IF 6.1 2区环境科学与生态学 Q1 ENVIRONMENTAL SCIENCES

Ecotoxicology and Environmental Safety Pub Date : 2025-09-20 DOI:10.1016/j.ecoenv.2025.119059

Amara Saleem , Andrew Volz , Tanmoy Mondal , Christopher A. Loffredo , Tomas Trnovec , Lubica Palkovicova Murinova , Kamil Conka , Beata Drobna , Somiranjan Ghosh

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引用次数: 0

Abstract

Polychlorinated biphenyls (PCBs) are persistent organic pollutants known to have deleterious effects on child and adult development; however, less is known about the relationship between mother-newborn exposure levels. The objective of this study is to understand prenatal PCB exposure and its association with gene expression, using data from a cohort of exposed mothers and infants in eastern Slovakia. For 91 mothers and infants participating in this study, serum PCB concentrations were determined using gas chromatography and high-resolution mass spectrometry. Affymetrix microarray was performed utilizing Human Genome U133 Plus 2.0 gene chip. Statistical analysis compared the genetic expression levels of high versus low exposure mother-infant pairs (< 368.57 ng/g lipid vs. > 368.57 ng/g lipid). Statistical analysis results showed that mother's blood and cord blood PCB concentrations were highly correlated. Results showed that higher levels of PCB concentrations were associated with differential expressions of multiple genes. Global gene analysis identified significant dysregulation of genes XIST, EXOC6B, EIF1AY, and RPS4Y1. Gender-based gene analysis identified significant dysregulation of genes RUFY1, S100A8, ELOVL7, FXYD3, DEFB124, and DAB2. Further such investigations should be implemented to confirm these observations and more fully define the legacy of environmental PCB contamination.

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探索产前多氯联苯暴露与基因表达之间的关系：来自斯洛伐克新生儿研究的观察结果

多氯联苯是已知对儿童和成人发育有有害影响的持久性有机污染物；然而，人们对母亲与新生儿接触水平之间的关系知之甚少。本研究的目的是了解产前多氯联苯暴露及其与基因表达的关系，使用来自斯洛伐克东部暴露的母亲和婴儿队列的数据。对91名参与本研究的母亲和婴儿，使用气相色谱法和高分辨率质谱法测定血清多氯联苯浓度。Affymetrix微阵列采用Human Genome U133 Plus 2.0基因芯片。统计分析比较了高暴露和低暴露母婴对的遗传表达水平（<； 368.57 ng/g脂质对>； 368.57 ng/g脂质）。统计分析结果显示，母亲血液与脐带血PCB浓度高度相关。结果表明，较高的多氯联苯浓度与多个基因的差异表达有关。全局基因分析发现XIST、EXOC6B、EIF1AY和RPS4Y1基因显著失调。基于性别的基因分析发现RUFY1、S100A8、ELOVL7、FXYD3、DEFB124和DAB2基因显著失调。应进一步开展此类调查，以证实这些观察结果，并更充分地确定环境多氯联苯污染的遗留问题。

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来源期刊

Ecotoxicology and Environmental Safety 环境科学-毒理学

CiteScore

12.10

自引率

5.90%

发文量

1234

审稿时长

88 days

期刊介绍： Ecotoxicology and Environmental Safety is a multi-disciplinary journal that focuses on understanding the exposure and effects of environmental contamination on organisms including human health. The scope of the journal covers three main themes. The topics within these themes, indicated below, include (but are not limited to) the following: Ecotoxicology、Environmental Chemistry、Environmental Safety etc.