Science of the Total Environment最新文献

{"title":"Theoretical insights into the binding of mono/di-ethyl phthalates to superoxide dismutase and associated structural changes impairing antioxidant activity: A coupled molecular docking and dynamics simulation approach","authors":"Xiuli Fan ,&nbsp;Chenggang Gu ,&nbsp;Lezu Shen ,&nbsp;Zhengyuan Gao ,&nbsp;Xinglun Yang ,&nbsp;Yongrong Bian ,&nbsp;Fang Wang ,&nbsp;Xin Jiang","doi":"10.1016/j.scitotenv.2025.179667","DOIUrl":"10.1016/j.scitotenv.2025.179667","url":null,"abstract":"<div><div>Phthalic acid esters (PAEs) are plasticizers known to increase oxidative stress by impairing antioxidant defenses, including superoxide dismutase (SOD) activity. Since oxidative stress plays a critical role in disease development, the disruption of SOD function by PAEs presents a significant concern. However, the precise molecular mechanisms underlying the regulation of SOD activity remain unclear. This study investigated how diethyl phthalate (DEP) and its major metabolite, monoethyl phthalate (MEP), affected SOD activity using molecular docking and dynamics simulations. The results revealed that both DEP and MEP bound to SOD through weak hydrophilic interactions and hydrogen bonds with residues Lys9, Thr17, Asn51, Thr52, and Arg141 in the bottom of the enzyme's two subunit cavities. These interactions triggered structural changes, particularly in the electrostatic loop and catalytic channels, destabilizing SOD. DEP and MEP increased the enzyme's radius of gyration and solvent-accessible surface area while disrupting intra-protein interactions. MEP showed a stronger inhibitory effect, significantly altering SOD's conformation. This change correlated with reduced catalytic activity (R² &gt; 0.9). Consequently, the inhibition of the enzyme is primarily due to the disruption of Arg141's conformation and function, which weakens SOD's antioxidant defense and potentially contributes to diseases related to oxidative damage. These results underscore the health risks posed by PAEs, especially following metabolic transformation, and highlight the importance of addressing their oxidative impact.</div></div>","PeriodicalId":422,"journal":{"name":"Science of the Total Environment","volume":"983 ","pages":"Article 179667"},"PeriodicalIF":8.2,"publicationDate":"2025-05-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144083983","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluating the role of urban green infrastructure in combating traffic-related microplastic pollution","authors":"Abdullah Khan ,&nbsp;Valda Araminienė ,&nbsp;Ieva Uogintė ,&nbsp;Iveta Varnagirytė-Kabašinskienė ,&nbsp;Valentinas Černiauskas ,&nbsp;Valda Gudynaitė-Franckevičienė ,&nbsp;Algis Džiugys ,&nbsp;Lina Davulienė ,&nbsp;Edgaras Misiulis ,&nbsp;Mehri Davtalab ,&nbsp;Steigvilė Byčenkienė","doi":"10.1016/j.scitotenv.2025.179688","DOIUrl":"10.1016/j.scitotenv.2025.179688","url":null,"abstract":"<div><div>As cities grapple with the invisible threat of airborne microplastics (MPs), non-exhaust emissions, especially traffic-related MPs, contribute significantly to urban air pollution. While emission regulations have reduced exhaust pollutants, non-exhaust sources remain a significant challenge. Urban green infrastructure (UGI), valued for aesthetic and ecological functions, remains underexplored for MP mitigation. This study assesses the role of a <em>Thuja occidentalis</em> hedge in Kaunas, Lithuania, as a natural barrier against traffic-related MPs. Over a four-month seasonal campaign, passive deposition sampling was conducted at four distances from the street, with additional sampling in the hedge's absence for an experimental-control comparison. Optical microscopy revealed distinct size and shape distributions, while μ-FTIR spectroscopy confirmed dominant polymer compositions: PE (69.05 %) in spring, PIR (35.96 %) in winter, and ACRs (28.52 %) in summer. The highest average fragment concentration occurred in spring (98.25 %), while fibers peaked in winter (12.75 %). Black was dominant year-round, with the highest average in spring (55.35 %), followed by white in winter (42.16 %) and brown in spring (26.98 %). MPs in the 50–100 μm range were most abundant, reaching 55.26 % in spring. A similar trend appeared in vertical MP distribution. The most pronounced difference was noticed at (+1 m) behind the hedge, where MP concentration was 4.59 particles cm⁻² day⁻¹, significantly lower than 9.2 particles cm⁻² day⁻¹ in the control. The hedge showed peak removal efficiencies in summer (64.5 % total MPs, 64.3 % fragments, 71.4 % fibers). The 50–100 μm range exhibited the highest efficiency, averaging 67.25 % with a seasonal high of 94.24 % in spring. Strong Mantel (<em>rm</em>) and Pearson's (<em>r</em>) correlations of very small MPs (&lt;20 μm) at -1 m suggest a significant influence from tire wear, brake wear, and road dust resuspension. This study highlights Thuja hedge as an active defender against MP pollution, advocating for its strategic integration into urban design to enhance public health protection.</div></div>","PeriodicalId":422,"journal":{"name":"Science of the Total Environment","volume":"983 ","pages":"Article 179688"},"PeriodicalIF":8.2,"publicationDate":"2025-05-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144083982","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Physical mechanism of diurnal variability of onshore and offshore summer monsoon rainfall along the west coast of India","authors":"Pushpaleela Ancy ,&nbsp;Hamza Varikoden ,&nbsp;Chethalan Anthony Babu","doi":"10.1016/j.scitotenv.2025.179681","DOIUrl":"10.1016/j.scitotenv.2025.179681","url":null,"abstract":"<div><div>The west coast of India (WCI) experiences a distinct rainfall maximum during the summer monsoon, characterised by significant spatial and temporal variability. This study analyses the diurnal patterns and underlying mechanisms responsible for the variations over the WCI using TRMM_3B42 V7 precipitation dataset. Rainfall days are categorised into three types - onshore, offshore, and uniform - based on the distribution of rainfall aggregate within their respective regions, as determined by area-averaged daily rainfall time series analysis. Onshore days exhibit maximum rainfall over the windward mountain slopes, offshore days bring peak rainfall over the ocean near the coast, and uniform days show rainfall maxima over both land and adjacent oceans. Onshore and uniform days are characterised by afternoon rainfall peaks, while offshore days feature a morning rainfall maximum. The zonal wind and moisture transport play a critical role in modulating these rainfall patterns in addition to orography. During offshore days, strong zonal winds prevail over the Arabian Sea, whereas uniform and onshore events are associated with an eastward extension of the core of low-level westerlies. Enhanced zonal winds, moisture transport towards land, and strong ascending motion contribute to increased rainfall in these regions. Thermodynamic analysis reveals an unstable atmosphere extending to mid-levels, with a positive moist static energy anomaly indicating significant moisture transport into the region. This study highlights the combined influence of dynamic and thermodynamic processes, particularly the role of zonal winds and moisture transport, in shaping the diurnal and spatial distribution of monsoonal rainfall along the WCI.</div></div>","PeriodicalId":422,"journal":{"name":"Science of the Total Environment","volume":"983 ","pages":"Article 179681"},"PeriodicalIF":8.2,"publicationDate":"2025-05-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144083851","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Particulate and dissolved organic carbon losses in high latitude seaweed farms","authors":"Luiza Neves ,&nbsp;Kristin Smeby ,&nbsp;Ole Jacob Broch ,&nbsp;Geir Johnsen ,&nbsp;Murat Van Ardelan ,&nbsp;Jorunn Skjermo","doi":"10.1016/j.scitotenv.2025.179677","DOIUrl":"10.1016/j.scitotenv.2025.179677","url":null,"abstract":"<div><div>The role of macroalgae as natural sinks for carbon dioxide (CO₂) has long been recognized, and interest for climate mitigating solutions from seaweed cultivation is quickly rising. Erosion of biomass provides natural avenues for carbon sequestration at sea, yet data is still lacking for important European cultivars, particularly combining particulate (POC) and dissolved (DOC) organic carbon losses. In this study, data is provided on carbon uptake, lamina growth and erosion over two consecutive seasons for the kelp <em>Saccharina latissima</em> (Phaeophyceae) deployed in Autumn and Winter in Hitra, Norway. A short-term carbon exudation experiment was performed with the same kelp in 2023. By April, the typical harvest time for food applications, average losses to POC and DOC pools amounted to 15 and 34 g C m⁻² yr⁻¹, respectively, or 9 % and 19 % of the carbon net primary production (C-NPP) of the farm. Combined POC and DOC losses reached 101–247 g C m⁻² yr⁻¹ (40–47 % of C-NPP) by June. DOC exudation rates reached 4.1–7.6 mg C g⁻¹ h⁻¹ after 4 h incubation, reducing significantly after 24 h. On average, 29 % and 12 % of the carbon fixed by <em>S. latissima</em> was released as DOC from Autumn and Winter deployments, respectively, before the progression of bryozoan biofouling. POC and DOC losses provide a continuous source for carbon deposition, burial or further breakdown into RDOC, crucial for environmental impact assessments and carbon accounting methodologies. The study provides valuable data for future research on macroalgae cultivation and its contribution to global carbon mitigation efforts.</div></div>","PeriodicalId":422,"journal":{"name":"Science of the Total Environment","volume":"982 ","pages":"Article 179677"},"PeriodicalIF":8.2,"publicationDate":"2025-05-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144072751","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Decentralized sewage treatment and energy recovery in high-rise buildings using anaerobic baffle reactor coupled with plant biofilter reactor: A focus on surfactant and phenol removal","authors":"Waseem Raja ,&nbsp;Guntuboina Sai Nagendra Rohith ,&nbsp;Satinder Kaur Brar ,&nbsp;Pratik Kumar","doi":"10.1016/j.scitotenv.2025.179661","DOIUrl":"10.1016/j.scitotenv.2025.179661","url":null,"abstract":"<div><div>The emergence of phenols and surfactants in domestic wastewater, largely attributed to changing Water, Sanitation, and Hygiene (WASH) practices, presents treatment challenges for conventional centralized systems. This study evaluates the performance of an integrated Anaerobic Baffled Reactor (ABR) and Plant Biofilter Reactor (PBFR) system for decentralized wastewater treatment and biogas recovery, focusing on its applicability in high-rise infrastructures. Real domestic wastewater, containing ammonia (55 mg/L), soluble chemical oxygen demand (s-COD, 580 mg/L), phenols (16 mg/L), and surfactants (17 mg/L), was treated under varying hydraulic retention times (HRTs) of 1, 2, and 3 days. At an HRT of 2 days, the system achieved up to 76 % ammonia removal, while phenol and surfactant removal reached 52 % and 85 % at 3 days HRT. COD removal exceeded 60 % across all HRTs. Principal Component Analysis (PCA) was employed to statistically interpret treatment performance. Mass spectrometry identified degradation by-products of phenols and surfactants, and their influence on biogas generation was assessed. Gas chromatography analysis indicated a high-quality biogas yield (CH₄ &gt; 70 %, CO₂ ∼ 20 %). Adding dextrose significantly enhanced gas production by stimulating microbial metabolism compared to fructose and sucrose. However, high influent concentrations of phenols and surfactants exhibited inhibitory effects on microbial activity, emphasizing the need for controlled organic loading. MTT-based cytotoxicity assays confirmed the treated effluent's non-toxic nature. These findings demonstrate the technical feasibility of integrated ABR-PBFR systems for treating complex wastewater streams while enabling energy recovery. The study provides a scalable and sustainable framework for decentralized wastewater management in urban high-rise settings, supporting circular economy and sustainable water management objectives.</div></div>","PeriodicalId":422,"journal":{"name":"Science of the Total Environment","volume":"982 ","pages":"Article 179661"},"PeriodicalIF":8.2,"publicationDate":"2025-05-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144070453","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Green hospitals: maximizing health and climate benefits globally","authors":"David Rojas-Rueda","doi":"10.1016/j.scitotenv.2025.179692","DOIUrl":"10.1016/j.scitotenv.2025.179692","url":null,"abstract":"<div><div>Climate change poses unprecedented challenges to global health, with the healthcare sector itself contributing significantly to greenhouse gas emissions. This perspective presents an innovative, adaptable framework for integrating sustainable and climate-friendly practices into healthcare settings across diverse economic contexts. We examine energy efficiency, waste management, water sustainability, supply chain optimization, telemedicine, and biophilic design in healthcare. The framework provides implementation strategies, cross-cutting climate innovations, and explores interconnections between climate-smart healthcare, health equity, and global sustainability. Our findings suggest that implementing climate-smart healthcare can lead to significant reductions in carbon emissions, enhanced resilience to climate-related health threats, and improved health outcomes globally. We conclude that the healthcare sector can transform from a significant contributor to climate change into a leader in climate mitigation and adaptation, creating a more sustainable, resilient, and equitable global health system.</div></div>","PeriodicalId":422,"journal":{"name":"Science of the Total Environment","volume":"982 ","pages":"Article 179692"},"PeriodicalIF":8.2,"publicationDate":"2025-05-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144070451","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A framework for assessing uncertainties in drought projections under climate change: Insights from CMIP6 models","authors":"Omid Zabihi ,&nbsp;Azadeh Ahmadi ,&nbsp;Ali Torabi Haghighi","doi":"10.1016/j.scitotenv.2025.179679","DOIUrl":"10.1016/j.scitotenv.2025.179679","url":null,"abstract":"<div><div>The impact of climate change on hydrology and drought is commonly assessed using General Circulation Models (GCMs), which introduce considerable uncertainty. This study presents a structured framework to evaluate these uncertainties, focusing on key hydrological parameters and drought characteristics. A multi-criteria statistical approach was used to assess the performance of three selected CMIP6 GCMs- ACCESS-CM2, CanESM5, and ACCESS-ESM1–5- under SSP245 and SSP585 scenarios. Drought conditions were analyzed using the Standardized Precipitation Index (SPI) and the Standardized Precipitation Evapotranspiration Index (SPEI), the latter capturing temperature-driven evapotranspiration. The uncertainty framework integrates a Bayesian probabilistic method for estimating the distribution of drought classifications and a polynomial-based decomposition approach to evaluate the temporal evolution of uncertainty. Applied to six major Iranian watersheds, CanESM5 under SSP585 projected the most extreme outcomes, including a 1.71-fold increase in annual precipitation in the Eastern border watershed and a 0.87-fold decrease in the Persian Gulf watershed. The highest temperature increase, 2.97 °C, was observed in the Caspian Sea watershed. Results indicate a higher probability of normal drought conditions across all watersheds, followed by moderately dry and moderately wet events. Temperature projections showed greater sensitivity to emission scenarios than precipitation, and uncertainties, particularly from GCMs and emission pathways, increased over time. The combined use of Bayesian inference and variance decomposition provides a robust framework for quantifying both the magnitude and sources of uncertainty in drought projections.</div></div>","PeriodicalId":422,"journal":{"name":"Science of the Total Environment","volume":"982 ","pages":"Article 179679"},"PeriodicalIF":8.2,"publicationDate":"2025-05-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144070678","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Diurnal variations of indoor short-lived radon daughters with positive 218Po and 214Pb clusters and their impact on atmospheric air ions","authors":"Maged Ahmed Saleh Abdo ,&nbsp;Fatima Ezzahra Arhouni ,&nbsp;Saad Ouakkas ,&nbsp;Aziz Boukhair ,&nbsp;Hamid Nebdi ,&nbsp;Mohammed Fahad","doi":"10.1016/j.scitotenv.2025.179666","DOIUrl":"10.1016/j.scitotenv.2025.179666","url":null,"abstract":"<div><div>Airborne radon progenies (²¹⁸Po, ²¹⁴Pb and ²¹⁴Po) are classified as radioactive aerosols and pose a significant public health risk when inhaled indoors. They are the largest source of natural radiation exposure and play a key role in environmental ionization, affecting aerosol size distribution. Thus, accurate measurements of these contaminants are crucial for understanding and controlling airborne radioactivity, providing basic parameters for assessing atmospheric air pollution levels. Therefore, continuous indoor measurements were conducted at 2-h intervals across various seasons during 2023 and 2024 in El Jadida, Morocco, considering meteorological parameters. The measurement method involves sampling the aerosol-attached radon progeny on filters, followed by α-counting using nuclear track detectors (CR-39) based on a three-count approach. Additionally, we have developed PC-based software that utilizes experimental measurements as input data to solve differential equations and calculate all necessary physical quantities. The ²²²Rn, ²¹⁸Po, ²¹⁴Pb and ²¹⁴Po annual average concentrations were 80.2 ± 6.6, 44.0 ± 3.6, 34.5 ± 2.8, and 24.3 ± 2.0 Bq/m³, respectively, with ²¹⁸Po and ²¹⁴Pb unattached activity of 11.2 and 0.6 Bq/m³. These concentrations exhibited significant diurnal variations of 3–4 times with maxima in the early morning and minima in the afternoon, while they changed seasonally by 30–50 % with peaks occurring in the colder months. Diurnal variations in radon-linked ionization rates and corresponding air ion concentrations are subject to changes in these radionuclides levels, with annual averages of 27.9 ion-pairs cm⁻³ s⁻¹ and 2113 ions/cm³ respectively. Results indicated that, under normal home conditions, about 52 % of ²¹⁸Po and 49 % of ²¹⁴Pb clusters are positively charged.</div></div>","PeriodicalId":422,"journal":{"name":"Science of the Total Environment","volume":"982 ","pages":"Article 179666"},"PeriodicalIF":8.2,"publicationDate":"2025-05-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144070454","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Soil fungal communities under plantations of different Eucalyptus species in Ethiopia: Insights for evidence-based management","authors":"Gonfa Kewessa ,&nbsp;Tatek Dejene ,&nbsp;Pablo Martín-Pinto","doi":"10.1016/j.scitotenv.2025.179663","DOIUrl":"10.1016/j.scitotenv.2025.179663","url":null,"abstract":"<div><div>The rapid expansion of <em>Eucalyptus</em> plantations in Ethiopia is driven by the increasing demand for woody products, raising concerns about their ecological impact. While conserving native forests remains a priority, <em>Eucalyptus</em> plantations provide alternative sources of forest products and income, helping to reduce pressure on native ecosystems. However, the ecological implications of these plantations, particularly their impact on soil fungal communities, key players in nutrient cycling and ecosystem functioning, remain poorly understood. This study investigates soil fungal community dynamics in <em>Eucalyptus globulus</em> and <em>Eucalyptus camaldulensis</em> plantations across diverse environmental gradients in Ethiopia. Soil samples were collected from 24 plots, and fungal DNA was extracted and sequenced using Illumina MiSeq technology, targeting the ITS2 region. Taxonomic classification and functional guild assignment were performed. Although both plantation types supported a high level of fungal richness and diversity, fungal community composition significantly varied by the <em>Eucalyptus</em> species. Environmental factors, including elevation, precipitation, and temperature, were linked to variations in fungal community composition, creating distinct ecological niches. The main indicator taxa under <em>E. camaldulensis</em> were the species <em>Yurkovia mendeliana</em>, <em>Fusarium oxysporum</em>, <em>Talaromyces solicola</em>, and <em>Westerdykella reniformis</em>, as well as an unidentified member of the class Chytridiomycetes. Under <em>E. globulus</em>, the main indicator taxa were the species <em>Saitozyma podzolica</em>, <em>Brachiosphaera tropicalis</em>, <em>Pseudoacremonium sacchari</em>, and <em>Preussia flanaganii</em>, along with an unidentified member of the order Hypocreales. Although the species <em>Archaeorhizomyces finlayi</em> and members of the families Hydnangiaceae and Chaetomiaceae and the order Sordariales were present in both plantation types, their relative abundances differed significantly between the two species. Our findings highlight that expanding <em>Eucalyptus</em> plantations support soil fungal diversity. A mosaic landscape combining the two species at the landscape level could enhance fungal biodiversity and ecosystem functionality. Understanding these fungal associations provides valuable insights for evidence-based plantation management and sustainable forestry practices in Ethiopia.</div></div>","PeriodicalId":422,"journal":{"name":"Science of the Total Environment","volume":"982 ","pages":"Article 179663"},"PeriodicalIF":8.2,"publicationDate":"2025-05-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144070524","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Outdoor temperature as a confounder of blood pressure in randomized trials","authors":"Doug Brugge ,&nbsp;Misha Eliasziw ,&nbsp;Amy Mertl ,&nbsp;Sharly Palma ,&nbsp;Chermaine Morson ,&nbsp;Teresa Vazquez-Dodero ,&nbsp;Warren Goldstein-Gelb ,&nbsp;Anil Gurcan ,&nbsp;Sangita Kunwar ,&nbsp;Hunter Gates ,&nbsp;Scott Oakley Hersey ,&nbsp;Francesca Majluf ,&nbsp;Wig Zamore","doi":"10.1016/j.scitotenv.2025.179683","DOIUrl":"10.1016/j.scitotenv.2025.179683","url":null,"abstract":"<div><h3>Background</h3><div>Temperature is a time varying factor that is associated with blood pressure and has the potential to be a confounder in randomized crossover trials.</div></div><div><h3>Methods</h3><div>We assessed the effect of temperature on blood pressure within the Home Air Filtration for Traffic-Related Air Pollution study, a randomized crossover trial of air purifiers in homes. We assessed the association of blood pressure with both outdoor and indoor temperatures using 190 paired blood pressure measurements that were not affected by the presence of air purifiers in the preceding month.</div></div><div><h3>Results</h3><div>Mean (standard error) peripheral systolic blood pressure was observed to change by +0.24 (0.09) mmHg per 1 °F colder outdoor temperature and by −0.28 (0.07) mmHg per 1 °F warmer (<em>P</em> &lt; 0.001). Results were similar, although somewhat smaller for peripheral diastolic blood pressure. Associations were nearly identical for central blood pressures. We found much smaller effects for indoor temperatures, none of which approached statistical significance, as indoor temperatures were more stable and did not change as much over the study period.</div></div><div><h3>Conclusions</h3><div>Despite the cooling and warming of outdoor temperatures being associated with increases and decreases in blood pressure, we believe that outdoor temperature may also be a surrogate marker of particulate matter air pollution. Regardless of the underlying mechanism, randomized trials using blood pressure as outcomes would be well advised to measure temperature and consider it a potential time-varying confounder in the analyses.</div></div>","PeriodicalId":422,"journal":{"name":"Science of the Total Environment","volume":"982 ","pages":"Article 179683"},"PeriodicalIF":8.2,"publicationDate":"2025-05-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144070452","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}