SCAPIS队列中的代谢综合征——低水平暴露于环境空气污染的相关性调查

IF 8 1区环境科学与生态学 Q1 ENVIRONMENTAL SCIENCES

Science of the Total Environment Pub Date : 2025-07-25 DOI:10.1016/j.scitotenv.2025.180120

Martin Tondel , Marta A. Kisiel , Lars Barregard , Marcus Dahlquist , Karl Kilbo Edlund , Charlotta Eriksson , Jenny Lindvall , Stefan Ljunggren , Petter Ljungman , Mare Lõhmus , Johan Nilsson Sommar , Tobias Nordquist , Anna Oudin , Göran Pershagen , Leo Stockfelt , Yiyi Xu , Mikael Ögren , Magnus Svartengren

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引用次数: 0

摘要

研究表明，长期暴露于高水平空气污染与代谢综合征（MetS）风险增加有关。我们的目标是在非常低的水平上研究这种关系，研究得较少，但对公共卫生具有重要意义。方法瑞典心肺生物图像研究（SCAPIS）由瑞典6个大城市随机选择的50-64岁的受试者（n = 30154）组成。参与者在入组时接受了体检并回答了健康相关问卷。MetS是根据既定标准定义的。在入组前的10年里，每年对每个受试者进行PM2.5和二氧化氮的居住暴露建模。调整流行率（adj PR）按暴露四分位数和PM2.5和NO2每增加1 μg/m3计算，并对年龄、生活方式和社会经济因素进行调整。结果分别获得了13997名（90.26%）女性和12978名（88.61%）男性的暴露、协变量和MetS的完整信息。入组前10年PM2.5和NO2平均暴露量分别为6.57和11.47 μg/m3。met在女性和男性的患病率分别为28.75%和38.20%。PM2.5的四分位数分析没有显示met的adj PR显著增加，无论是女性还是男性。雌虫每1 μg/m3的adj PR为0.91(0.89 ~ 0.94)，雄虫为0.95（0.92 ~ 0.97）。NO2也有类似的关联，但关联程度较弱。结论：空气污染与met之间存在一些负相关，但由于横断面设计的局限性，这些结果应谨慎解释。结果不应超出我们研究的暴露范围进行解释。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Metabolic syndrome in the SCAPIS cohort — Investigating associations at low level exposure to ambient air pollution

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Metabolic syndrome in the SCAPIS cohort — Investigating associations at low level exposure to ambient air pollution

Background

Studies on long-term exposure to air pollution at high levels suggest an association with increased risk of metabolic syndrome (MetS). We aimed to study this relationship at very low levels, less well-studied, yet of public health importance.

Methods

The Swedish CArdioPulmonary bioImage Study (SCAPIS) consists of randomly selected subjects aged 50–64 years from six large cities in Sweden (n = 30,154). Participants underwent medical examination and answered a health-related questionnaire at enrolment. MetS was defined using established criteria. Residential exposure to PM_2.5 and NO₂ was modelled annually for each subject over 10 years before enrolment. Adjusted prevalence ratios (adj PR) were calculated both by quartiles of exposure and per 1 μg/m³ increment in PM_2.5 and NO₂, with adjustments for age, lifestyle and socioeconomic factors.

Results

Full information on exposure, covariates, and MetS was obtained for 13,997 (90.26 %) females and 12,978 (88.61 %) males, respectively. The 10-years mean exposures of PM_2.5 and NO₂ before enrolment were 6.57 and 11.47 μg/m³, respectively. The prevalence of MetS was 28.75 % in females and 38.20 % in males, respectively. Quartile analysis of PM_2.5 did not reveal significant increased adj PR for MetS, neither in females nor in males. For females the adj PR per 1 μg/m³ was 0.91 (0.89–0.94) and for males 0.95 (0.92–0.97), respectively. Similar, but somewhat weaker, associations were seen for NO₂.

Conclusion

Some inverse associations between air pollution and MetS were observed, but these results should be interpreted with caution due to limitations in the cross-sectional design. Results should not be interpreted beyond our studied exposure range.

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来源期刊

Science of the Total Environment 环境科学-环境科学

CiteScore

17.60

自引率

10.20%

发文量

8726

审稿时长

2.4 months

期刊介绍： The Science of the Total Environment is an international journal dedicated to scientific research on the environment and its interaction with humanity. It covers a wide range of disciplines and seeks to publish innovative, hypothesis-driven, and impactful research that explores the entire environment, including the atmosphere, lithosphere, hydrosphere, biosphere, and anthroposphere. The journal's updated Aims & Scope emphasizes the importance of interdisciplinary environmental research with broad impact. Priority is given to studies that advance fundamental understanding and explore the interconnectedness of multiple environmental spheres. Field studies are preferred, while laboratory experiments must demonstrate significant methodological advancements or mechanistic insights with direct relevance to the environment.