Miguel Inácio , Eglė Baltranaitė , Marija Meišutovič-Akhtarieva , Damià Barceló , Wenwu Zhao , Paulo Pereira
{"title":"Mapping agricultural ecosystem services. A systematic review","authors":"Miguel Inácio , Eglė Baltranaitė , Marija Meišutovič-Akhtarieva , Damià Barceló , Wenwu Zhao , Paulo Pereira","doi":"10.1016/j.scitotenv.2025.179499","DOIUrl":"10.1016/j.scitotenv.2025.179499","url":null,"abstract":"<div><div>Agriculture is one of the major drivers of land degradation and climate change. It is known that it can have positive impacts on provisioning ecosystem services (ES) (e.g., food production); however, it has as well detrimental effects on regulation and maintenance (e.g., carbon sequestration) and cultural ES (e.g., landscape aesthetics). Mapping helps us to understand the spatio-temporal impacts on agriculture ES. Nevertheless, no global assessment on mapping agriculture ES was conducted. To fill this gap, this work aims to review the studies systematically focused on mapping agriculture ES, following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses statement protocol. Overall, 52 studies were considered in this analysis. The results showed an increase in research from 2013 to 2024, mainly developed in Europe and Asia, with a special focus on the rural regions of the countries. Most studies did not follow a specific ES classification, focused on ES supply and assessed one ES dimension. <em>Cultivated terrestrial plants for nutrition, materials or energy</em> was the most mapped provisioning ES group. <em>Regulation of baseline flows and extreme events</em> and <em>Intellectual and representative interactions with the natural environment</em> were the most analysed regulation & maintenance and cultural ES groups, respectively. Regarding the methodology, the majority of studies applied mixed approaches. Finally, a large proportion of works did not consider any tradeoffs, drivers of change, and future predictions and did not validate the obtained ES model results. This work is key to understanding the areas where agricultural ES were mapped and supporting policymaking to identify informed decisions.</div></div>","PeriodicalId":422,"journal":{"name":"Science of the Total Environment","volume":"981 ","pages":"Article 179499"},"PeriodicalIF":8.2,"publicationDate":"2025-05-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143904126","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Corrigendum to: “Retrieve water quality parameters of urban rivers from hyperspectral images through feature interaction based two-stage method fused with spectral unmixing and spatial relatedness” [Sci. Total. Environ. 956 (2024) 177115]","authors":"Yishan Zhang , Ziyao Yang","doi":"10.1016/j.scitotenv.2025.179601","DOIUrl":"10.1016/j.scitotenv.2025.179601","url":null,"abstract":"","PeriodicalId":422,"journal":{"name":"Science of the Total Environment","volume":"980 ","pages":"Article 179601"},"PeriodicalIF":8.2,"publicationDate":"2025-05-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143922301","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Anna E. Windle , Sairah Y. Malkin, Raleigh R. Hood, Greg M. Silsbe
{"title":"Optical water typing in optically complex waters: A case study of Chesapeake Bay","authors":"Anna E. Windle , Sairah Y. Malkin, Raleigh R. Hood, Greg M. Silsbe","doi":"10.1016/j.scitotenv.2025.179558","DOIUrl":"10.1016/j.scitotenv.2025.179558","url":null,"abstract":"<div><div>Optical water typing has been widely used in aquatic research to classify water bodies based on their inherent optical properties as perceived through satellite-based measures of water color. While optical water type (OWT) classifications have primarily been used to better understand water color dynamics and improve satellite-based estimates of water clarity, chlorophyll <em>a,</em> and other optically active constituents, its potential for broader water quality assessment has received less attention. In this study, we examine the relationships between a suite of water quality parameters, including nutrient concentrations, and OWTs in Chesapeake Bay, an optically complex temperate estuary with an extensive water quality monitoring program. Using machine learning, we grouped R<sub>rs</sub> data into ten dominant OWTs; the optimum number of clusters identified from a statistical within-cluster dispersion test. These OWTs ranged from brown to blue/green estuarine waters and emerged with high spatial contiguity. By analyzing synchronously measured discrete water quality variables grouped by corresponding OWTs, unexpected patterns became evident. Notably, total nitrogen concentration emerged as having statistically significant differences between OWTs, suggesting our approach can enhance understanding of nutrient pollution at the scale of a large optically complex estuary, especially in times of reduced fixed sampling routines (e.g., winter). This study aids in the interpretation of Bay-wide water quality trends, can assist in the dynamic selection of water quality retrieval algorithms, and provides high resolution data to identify regions of water quality impairment.</div></div>","PeriodicalId":422,"journal":{"name":"Science of the Total Environment","volume":"981 ","pages":"Article 179558"},"PeriodicalIF":8.2,"publicationDate":"2025-05-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143907787","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Hany S. Osman , Yan Gao , Zhicheng Luo , Khadiga Alharbi , Emadeldeen Rashwan , Alaa El-Dein Omara , Emad M. Hafez
{"title":"Integrative use of biochar and biostimulants improves cadmium detoxification and yield in cotton","authors":"Hany S. Osman , Yan Gao , Zhicheng Luo , Khadiga Alharbi , Emadeldeen Rashwan , Alaa El-Dein Omara , Emad M. Hafez","doi":"10.1016/j.scitotenv.2025.179585","DOIUrl":"10.1016/j.scitotenv.2025.179585","url":null,"abstract":"<div><div>Dealing with abiotic stress is a challenge to maintaining sustainable agricultural productivity, especially for the dual stress of soil salinity and heavy metal contamination. A field experiment was conducted in a completely randomized factorial design to assess the combined effects of biochar (BC), plant growth-promoting microorganisms (PGPM), and seaweed extract (SWE) in mitigating cadmium (Cd) toxicity while promoting cotton growth in saline soils. The study included eight treatments: control (CK), single applications of SWE, PGPM, or BC, dual applications of BC + SWE, BC + PGPM, and PGPM + SWE, and a triple application (BC + PGPM + SWE). Results showed that the BC + PGPM + SWE treatment significantly improved soil quality by reducing the Na and Cd bioavailability by 31 % and 34 %, respectively, while enhancing soil organic matter, microbial biomass carbon, and soil enzymatic activity. Antioxidant defense mechanisms in cotton leaves were significantly induced, as indicated by enhanced activity of SOD, APX, DHAR and GR from 1.8-folds in SOD to 3.4-folds the control in GR. Multivariate analysis revealed that enzymatic and non-enzymatic antioxidants of the ascorbate-glutathione cycle seemed to play a key role in oxidative stress mitigation with maintenance of redox homeostasis and chelation of Cd, resulting in a reduction of 18 % and 56 % in Cd translocation factors from root to shoot, and from shoot to bolls, which contributing to a 65 % increase in cotton seed yield. This study demonstrates an integrative approach to enhancing the resilience of the soil and its productivity, thereby offering a scaling-up, eco-friendly strategy toward sustainable agriculture in degraded and stress-prone ecosystems.</div></div>","PeriodicalId":422,"journal":{"name":"Science of the Total Environment","volume":"981 ","pages":"Article 179585"},"PeriodicalIF":8.2,"publicationDate":"2025-05-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143907786","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Lucía Martín-Gisbert , Alberto Ruano-Raviña , Guadalupe García , María Piñeiro-Lamas , Marta García-Talavera , Ana Teijeiro , Cristina Candal-Pedreira
{"title":"Duration versus intensity of exposure on the risk of lung cancer due to radon exposure in the general population","authors":"Lucía Martín-Gisbert , Alberto Ruano-Raviña , Guadalupe García , María Piñeiro-Lamas , Marta García-Talavera , Ana Teijeiro , Cristina Candal-Pedreira","doi":"10.1016/j.scitotenv.2025.179569","DOIUrl":"10.1016/j.scitotenv.2025.179569","url":null,"abstract":"<div><div>Indoor radon causes lung cancer. The objective of this investigation is to describe lung cancer risk based both on duration and intensity of radon exposure, and to analyze if this effect could be different by sex. To do this, we used pooling information coming from very similar case-control studies on radon and lung cancer, all performed in a radon-priority area. We did a classical categorical analysis using logistic regressions to predict lung cancer risk for exposure duration, intensity of exposure and both variables combined, and we also employed generalized additive models to assess the risk of lung cancer. The results were obtained separately by sex. We included 3415 participants for whom radon measurements had been performed at their home, 1619 of whom were cases. We observed that the length and intensity of residential radon exposure might have a similar importance on lung cancer risk. For those living in dwellings with radon concentrations above 300 Bq/m<sup>3</sup>, lung cancer risk increases steadily and importantly with exposure duration, even with lengths of exposure above 40 years. We also observed that the risk of lung cancer might be higher in men compared to women. We encourage other researchers to reanalyze their data to confirm these results and also to test if the effect observed in women is replicated.</div></div>","PeriodicalId":422,"journal":{"name":"Science of the Total Environment","volume":"981 ","pages":"Article 179569"},"PeriodicalIF":8.2,"publicationDate":"2025-05-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143904127","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Yuanyao Ye , Xueyi Yan , Yuanshou Jiang , Songlin Wang , Dongqi Liu , Yongzheng Ren , Daosheng Li , Huu Hao Ngo , Wenshan Guo , Dongle Cheng , Wei Jiang
{"title":"Optimized feeding schemes of heterotrophic anodic denitrification coupled with cathodic phosphate recovery from wastewater using a microbial fuel cell","authors":"Yuanyao Ye , Xueyi Yan , Yuanshou Jiang , Songlin Wang , Dongqi Liu , Yongzheng Ren , Daosheng Li , Huu Hao Ngo , Wenshan Guo , Dongle Cheng , Wei Jiang","doi":"10.1016/j.scitotenv.2025.179590","DOIUrl":"10.1016/j.scitotenv.2025.179590","url":null,"abstract":"<div><div>Enhanced water quality standards and increasing resource scarcity have prompted extensive research into low-cost nitrogen removal and phosphate recovery from wastewater. Microbial fuel cells (MFCs) offer a viable solution by simultaneously removing nitrogen, recovering phosphorus, and generating electrical energy. This study employed MFCs to achieve simultaneous nitrogen removal and phosphorus recovery, investigating the impact of different feeding schemes. The experimental results indicated that replacing the entire anode chamber solution and recycling the anode effluent to the cathode chamber effectively prevented the accumulation of nitrifying bacteria while achieving the highest pollutant removal performance. Under closed circuit conditions, the system consistently maintained low nitrite concentrations, achieving an average nitrate removal efficiency of 68.09 ± 1.86 % and phosphate recovery efficiency of 83.46 ± 5.30 %. Furthermore, this feeding scheme facilitated microbial growth and reproduction while also improving operational convenience. The study utilized metagenomics and other technologies to comprehensively analyze the system's operation mechanism and reasons for its excellent performance.</div></div>","PeriodicalId":422,"journal":{"name":"Science of the Total Environment","volume":"981 ","pages":"Article 179590"},"PeriodicalIF":8.2,"publicationDate":"2025-05-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143907788","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
E. Botezat , C. Linares , P. Salvador , M.A. Navas , J. Díaz , J.A. López-Bueno
{"title":"How air pollution affects cause-specific emergency hospital admissions on days with biomass combustion in Spain?","authors":"E. Botezat , C. Linares , P. Salvador , M.A. Navas , J. Díaz , J.A. López-Bueno","doi":"10.1016/j.scitotenv.2025.179560","DOIUrl":"10.1016/j.scitotenv.2025.179560","url":null,"abstract":"<div><div>Although wildfires are growing in number, intensity and extent due to climate change, few studies have been undertaken to analyse their health impact, and fewer still to analyse the impact of variables other than particulate matter.</div><div>The objective of this study is to analyse the short-term impact of NO<sub>2</sub>, PM<sub>10</sub>, PM<sub>2.5</sub>, O<sub>3</sub> and temperature in heat waves on emergency hospital admissions in Spain on days when biomass combustion occurs.</div><div>We conducted an ecological longitudinal time series study across the period 2013–2018. The dependent variables were emergency hospital admissions due to all causes (ICD-10: A00-R99), circulatory causes (ICD-10: I00-I99) and respiratory causes (ICD-10: J00-J99) in 9 representative Spanish provinces. The independent variables were daily mean air pollution concentrations measured at a provincial level. We also included daily maximum temperatures recorded at reference observatories in the respective provinces. Poisson generalised linear models were fitted for days with and without PM advections due to biomass burning smoke. We controlled for trends, seasonalities, the autoregressive nature of the series, Sundays and Public Holidays.</div><div>Days with biomass burning smoke advections increased PM concentrations in all provinces and ozone in many of them, something that did not occur in equal measure in the case of NO<sub>2</sub>. Nevertheless, the principal impact on admissions was due to O<sub>3</sub>, followed by NO<sub>2</sub>, PM, and lastly, heat-wave temperatures. This pattern was observed for all three causes analysed. The role of PM was relegated to that of a third factor, and the role of temperature to an order of lesser magnitude than that of chemical pollution.</div><div>To focus the health impacts of wildfires exclusively on the impact of PM concentrations would be to minimise their real impact on population health. It is therefore essential to implement integrated plans that take into account the joint effect of all atmospheric variables affected.</div></div>","PeriodicalId":422,"journal":{"name":"Science of the Total Environment","volume":"981 ","pages":"Article 179560"},"PeriodicalIF":8.2,"publicationDate":"2025-05-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143904222","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Mateus Brandão Marques , Emilly Vitória Ferreira Reis , Pedro Felipe Pereira Gonzaga , Jamerson Aguiar-Santos , Vanessa Baptista Pedrosa , Jorge Luiz Silva Nunes , Tatiana Dillenburg Saint'Pierre , Marianna Basso Jorge , Rachel Ann Hauser-Davis , Ricardo Luvizotto-Santos
{"title":"Associations between metals and metalloids, oxidative stress and genotoxicity in Nurse sharks Ginglymostoma cirratum from the Brazilian Amazon Coast","authors":"Mateus Brandão Marques , Emilly Vitória Ferreira Reis , Pedro Felipe Pereira Gonzaga , Jamerson Aguiar-Santos , Vanessa Baptista Pedrosa , Jorge Luiz Silva Nunes , Tatiana Dillenburg Saint'Pierre , Marianna Basso Jorge , Rachel Ann Hauser-Davis , Ricardo Luvizotto-Santos","doi":"10.1016/j.scitotenv.2025.179530","DOIUrl":"10.1016/j.scitotenv.2025.179530","url":null,"abstract":"<div><div>Elasmobranch populations have significantly declined in recent decades due to anthropogenic activities, with chemical contamination comprising one of the main threats to this group. Although some biochemical biomarkers have been utilized to assess elasmobranch health, especially concerning metal and metalloid contamination, associations with genotoxic biomarkers are still scarce and non-existent for Brazilian Amazon coast sharks. Herein, metals, metalloids, reduced glutathione (GSH), glutathione S-transferase (GST), metallothionein (MT), and nuclear anomalies (micronucleus, nuclear buds, and bilobed cells) were determined in gills, liver, and muscle tissues of Nurse sharks (<em>Ginglymostoma cirratum</em>) from the São Marcos Estuarine Complex, Maranhão, Brazil. Females exhibited significantly higher As concentrations in muscle (23.14 ± 13.98 μg g<sup>-1</sup>) and gills (4.53 ± 2.10 μg g<sup>-1</sup>) compared to males (3.98 ± 2.61 μg g<sup>-1</sup> and 1.51 ± 0.41 μg g<sup>-1</sup>, respectively) (p < 0.05). Males showed higher Se concentrations in muscle (0.52 ± 0.02 μg g<sup>-1</sup>) compared to females (0.32 ± 0.09 μg g<sup>-1</sup>) (p < 0.05), while Rb levels were higher in male liver (0.28 ± 0.05 μg g<sup>-1</sup>) than in females (0.18 ± 0.04 μg g<sup>-1</sup>) (p = 0.001). No significant differences were observed for Hg, Ti or rare earth elements (Ce and La) between sexes (p > 0.05). Higher GSH concentrations and GST activities were noted in gills and liver, while MT concentrations were higher in muscle. Low genotoxic damage frequency was observed, likely due to the species' sedentary lifestyle and efficient DNA repair system. Moderate to strong correlations between metals/metalloids and biochemical/genotoxic responses were detected, particularly in females, highlighting the protective role of GST against DNA damage. Protective effects of Se against Hg were observed in the liver. Metal concentrations did not exceed regulatory limits, although bioaccumulation patterns and physiological responses suggest that Nurse sharks are exposed to environmental contamination, with As and Se accumulation.</div></div>","PeriodicalId":422,"journal":{"name":"Science of the Total Environment","volume":"981 ","pages":"Article 179530"},"PeriodicalIF":8.2,"publicationDate":"2025-05-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143907784","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Forecasting climate change effects on Saline Lakes through advanced remote sensing and deep learning","authors":"Huayu Lu , Marzieh Mokarram","doi":"10.1016/j.scitotenv.2025.179582","DOIUrl":"10.1016/j.scitotenv.2025.179582","url":null,"abstract":"<div><div>Given the vital role of saline lakes in supporting ecosystems in arid regions, this study analyzes their long-term changes by assessing their characteristics and spectral reflectance properties. Alongside evaluating the physical and chemical variations of these lakes, the research integrates climate change modeling to predict future shifts in their features and assess ecological impacts on surrounding environments. By employing Super-Resolution Generative Adversarial Network (SRGAN) and Multiresolution Segmentation (MRS), this approach enhances satellite image resolution and enables more precise differentiation of key lake components—such as salt deposits, salinity levels, and moisture fluctuations. The results show that increasing image resolution with SRGAN and using these images as input data for image classification models improves the identification of physical characteristics and the prediction of chemical properties of lakes with greater detail. The proposed method, based on Cellular Automata (CA)-Markov modeling of albedo and infrared wave reflectance, predicts a roughly 15 % increase in salinity of the studied lakes by 2050, driven by rising temperatures, intensified evaporation, and declining moisture levels. Finally, the results of climate change predictions based on the Long Short-Term Memory (LSTM) algorithm, with high accuracy (R<sup>2</sup> > 0.9), indicate increasing temperatures and evaporation in the coming years. Consequently, these rising temperatures will elevate salinity, drying, and albedo intensity in Chaka, Tuz, and Razzaza Lakes over the coming decades. This is supported by RCP8.5 scenarios, which project significant increases by 2100 that lead to greater evaporation and salinity. These changes have profound implications for surrounding ecosystems, particularly by affecting plant communities and accelerating desertification around these saline lakes.</div></div>","PeriodicalId":422,"journal":{"name":"Science of the Total Environment","volume":"980 ","pages":"Article 179582"},"PeriodicalIF":8.2,"publicationDate":"2025-05-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143904399","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Aluminium oxide nanoparticles (Al2O3-NPs) exposure impairs cardiovascular physiology and elevates health risk – proteomic and molecular mechanistic insights","authors":"Gobichettipalayam Balasubramaniam Maadurshni , Balamurali Mahalakshmi , Manikandan Nagarajan , Jeganathan Manivannan","doi":"10.1016/j.scitotenv.2025.179576","DOIUrl":"10.1016/j.scitotenv.2025.179576","url":null,"abstract":"<div><div>The interactions of nanoparticles with biomolecules lead to toxicopathological outcomes through various mechanisms including oxidative stress. In this regard, the interplay of oxidative stress with other molecular mechanisms of cytotoxicity during aluminium oxide nanoparticles (Al<sub>2</sub>O<sub>3</sub>-NPs) induced cardiovascular toxicity was not yet precisely explored. Initially, the human serum protein interaction and its corona composition were explored through the gel/label-free proteomics (nLC-HRMS/MS) method. In addition, endothelial cells (EC) and cardiomyoblasts (CM) cultures were employed along with various oxidative stress and cell stress assays. Further, various expression studies (RT-qPCR, western blot, and immunofluorescence), kinase signalling, and siRNA mediated gene knockout assays were performed. Alongside, the <em>in ovo</em> impact on antioxidant enzymes and metabolomic pathways (<sup>1</sup>H NMR) in the heart validated the role of oxidative stress during cardiotoxicity. The current outcome illustrates the dose-dependent increase of cytotoxicity and caspase (3 and 9) activation. The dose-dependent elevation and its synergy with cardiovascular stress signalling (ET-1 and Ang-II) illustrate the prominent role of oxidative stress during toxicity. In conclusion, the current study connects the role of the redox system and molecular stress pathways during Al<sub>2</sub>O<sub>3</sub>-NPs induced cardiotoxicity which extends the knowledge towards the precise health risk assessment during human exposure.</div></div>","PeriodicalId":422,"journal":{"name":"Science of the Total Environment","volume":"980 ","pages":"Article 179576"},"PeriodicalIF":8.2,"publicationDate":"2025-05-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143900320","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}