Science of the Total Environment最新文献

{"title":"Factors responsible for radiocesium transfer from soil to rice and soybeans after the Fukushima Daiichi Nuclear Power Plant accident","authors":"Shigeto Fujimura ,&nbsp;Kohji Yamamura ,&nbsp;Junko Ishikawa ,&nbsp;Katashi Kubo ,&nbsp;Shokichi Wakabayashi ,&nbsp;Takuro Shinano ,&nbsp;Hayato Maruyama ,&nbsp;Masataka Suzuki","doi":"10.1016/j.scitotenv.2025.180044","DOIUrl":"10.1016/j.scitotenv.2025.180044","url":null,"abstract":"<div><div>Understanding the effects of multiple factors on the accumulation of ¹³⁷Cs in grain is critical for determining the intensity and duration of countermeasures to reduce ¹³⁷Cs contamination of agricultural products. Here, using survey data of ¹³⁷Cs concentration in rice and soybean collected from the fields of farmers in Fukushima Prefecture, Japan, from 2012 to 2020, we developed comprehensive statistical models to evaluate grain-¹³⁷Cs simultaneously and quantitatively with several factors. The statistical models indicated that the exchangeable ¹³⁷Cs concentration in soil (Ex-¹³⁷Cs) was a more suitable indicator of soil ¹³⁷Cs contamination than the total ¹³⁷Cs concentration in the soil for predicting grain-¹³⁷Cs. Soybeans exhibited 12-fold higher grain-¹³⁷Cs than rice under the same Ex-¹³⁷Cs and exchangeable potassium concentration in the soil (Ex-K), primarily because of the higher ¹³⁷Cs uptake per dry matter production. The degree of reduction in grain-¹³⁷Cs estimated by Ex-¹³⁷Cs with increasing Ex-K was similar in rice and soybeans, suggesting that the inhibitory mechanism of K supply to the root zone on ¹³⁷Cs uptake was similar in both crops. However, the ratio of Ex-¹³⁷Cs to total ¹³⁷Cs in soil was more sensitive to Ex-K in soybean than in rice, indicating a difference in the dynamics of Ex-K and Ex-¹³⁷Cs between rice paddy fields and soybean upland fields. These results show that the dynamics of Ex-¹³⁷Cs in soil and the response to Ex-¹³⁷Cs are key factors regulating the difference in grain-¹³⁷Cs activity concentration between soybean and rice.</div></div>","PeriodicalId":422,"journal":{"name":"Science of the Total Environment","volume":"995 ","pages":"Article 180044"},"PeriodicalIF":8.2,"publicationDate":"2025-07-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144654399","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Increased reproductive cancer risks following early-life dichlorodiphenyltrichloroethane (DDT) exposure: Evidence from a historical population-based study in Taiwan (1952–1957)","authors":"Ya-Chi Chang ,&nbsp;Chi-Jen Chen ,&nbsp;Pau-Chung Chen","doi":"10.1016/j.scitotenv.2025.180067","DOIUrl":"10.1016/j.scitotenv.2025.180067","url":null,"abstract":"<div><div>Dichlorodiphenyltrichloroethane (DDT) was extensively applied for malaria control in Taiwan between 1952 and 1957, resulting in widespread early-life exposure. Limited evidence suggests that exposure to DDT during critical developmental windows may increase the risk of endocrine-related malignancies in adulthood. To investigate this association, we conducted a left-truncated cohort study utilizing Taiwan's National Health Insurance Research Database (NHIRD), including 2,327,099 individuals born during the DDT-based malaria eradication campaign. DDT exposure levels were estimated from historical indoor residual spraying records and categorized into six groups based on township-level spraying frequency (0–5 times). Kaplan–Meier survival analysis and Cox proportional hazards models were applied to estimate the association between early-life DDT exposure and the cumulative incidence of reproductive cancers. Over a 22-year follow-up (2000−2022), 81,592 reproductive cancer cases were identified. Each additional episode of township-level DDT spraying was significantly associated with an elevated cancer risk (aHR: 1.04, 95 % CI: 1.03–1.04 in women; aHR: 1.05, 95 % CI: 1.03–1.07 in men). Among women, breast (aHR: 1.04, 95 % CI:1.03–1.05), corpus uteri (aHR: 1.03, 95 % CI:1.01–1.05), and ovarian cancers (aHR: 1.06, 95 % CI:1.02–1.09) showed the strongest associations. In men, prostate cancer demonstrated the highest risk (aHR: 1.05, 95 % CI:1.03–1.07). A significant dose–response trend was observed (<em>p</em> &lt; 0.0001). This historical exposure setting, grounded in a unique context and a nationwide database, provides epidemiologic evidence on the potential association between early-life DDT exposure and long-term carcinogenic risk. The findings contribute to the limited body of evidence from Asia and underscore the need for long-term surveillance in countries where DDT spraying is still ongoing.</div></div>","PeriodicalId":422,"journal":{"name":"Science of the Total Environment","volume":"995 ","pages":"Article 180067"},"PeriodicalIF":8.2,"publicationDate":"2025-07-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144654398","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Coupling global climate drivers to dust emission dynamics at Etosha Pan, Namibia","authors":"Natasha S. Wallum ,&nbsp;Giles F.S. Wiggs ,&nbsp;Robert G. Bryant","doi":"10.1016/j.scitotenv.2025.180088","DOIUrl":"10.1016/j.scitotenv.2025.180088","url":null,"abstract":"<div><div>Ephemeral lake beds are globally significant sources of atmospheric mineral dust aerosols, but emissions from these topographic features are characterised by considerable spatial and temporal variability. Resolving the complex relationships between climatic and surface drivers that control aeolian emissivity has proven extremely challenging, leading to substantial uncertainty in model predictions of atmospheric dust loading and its impacts on other global-scale Earth system processes. This study uses a range of satellite-derived measurements (e.g., MSG-SEVIRI, MODIS) of mineral dust aerosols, lake inundation, catchment precipitation, and climate data (from meteorological stations and model reanalysis data sources) from 2000 to 2022 to assess the influence of regional climate and basin-scale hydrology on the emission of mineral dust from Etosha Pan in Namibia, a major Southern Hemisphere dust source. Significant associations were identified between interannual and seasonal variations in catchment rainfall, ephemeral pan surface inundation, and the frequency and magnitude of dust emissions over the two-decade analysis period. Results indicate that dust production is modulated by seasonal precipitation and ephemeral flooding events, which suppress dust emissions during wet periods and also lead to the delayed production of dust emissions on surface drying. During dry periods, wind speed variability was identified as the primary driver of dust emissions. These regional climate and hydrological factors were found to be closely linked to El Niño-Southern Oscillation (ENSO) phases and shifts in the subtropical Indian Ocean Dipole (SIOD), where seasonal increases (reductions) in dust emissions were associated with positive (negative) ENSO and negative (positive) SIOD events. The identification of robust links between dust emissions and global climate drivers in this study makes a significant contribution to the improved integration of ephemeral lake systems in dust emission models and opens the potential for forecasting future dust trends based on large-scale climate cycles.</div></div>","PeriodicalId":422,"journal":{"name":"Science of the Total Environment","volume":"995 ","pages":"Article 180088"},"PeriodicalIF":8.2,"publicationDate":"2025-07-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144654908","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"N-acetyl cysteine mediated inhibition of glucose regulated protein-78 abrogates activating transcription factor-4 dependent endoplasmic reticulum stress and neurodegeneration following exposure to di-2-ethylhexyl phthalate in zebrafish brain","authors":"Prerana Sarangi ,&nbsp;Lilesh Kumar Pradhan ,&nbsp;Suvam Bhoi ,&nbsp;Bhabani Sankar Sahoo ,&nbsp;Nishant Ranjan Chauhan ,&nbsp;Sangeeta Raut ,&nbsp;Saroj Kumar Das","doi":"10.1016/j.scitotenv.2025.180068","DOIUrl":"10.1016/j.scitotenv.2025.180068","url":null,"abstract":"<div><div>Recent findings have highlighted the neurological consequences of exposure to the plasticizer di-2-ethylhexyl phthalate (DEHP), including neurobehavioral transformation, cognitive dysfunction, and neurodegeneration. Endoplasmic reticulum (ER) stress plays a distinct role in altering cellular responses by inducing cell death. Based on existing literature, we were primarily interested in understanding whether the gross biochemical and neuromorphological outcomes of DEHP are associated with augmented ER stress in the neuronal microenvironment. Furthermore, we aimed to establish the neuroprotective efficacy of N-acetyl cysteine (NAC) against DEHP-induced ER stress in the zebrafish brain. Our core findings strongly support the argument that DEHP, being a global neurotoxicant, induces heightened oxidative stress and dysregulated calcium homeostasis, which contribute to ER stress mediated neurodegeneration via ATF4-dependent upregulation of GRP78 in the zebrafish brain. However, NAC reversed DEHP-induced calcium dysregulation (F4,20 = 11.97, p &lt; 0.05; n = 6/group) and ATF4-mediated (F4,8 = 11.05; p &lt; 0.05; n = 6/group) ER stress by inhibiting GRP78 (F4,8 = 31.83; p &lt; 0.05; n = 6/group) in the zebrafish brain. NAC also promoted neuroprotection through upregulation of endogenous BDNF (F₄,₈ = 13.93, p &lt; 0.05; n = 6/group) and NeuN (F₄,₈ = 56.95, p &lt; 0.05; n = 6/group) expression and inhibition of CC3-mediated (F₄,₈ = 22.03, p &lt; 0.05; n = 6/group) neurodegeneration in the periventricular grey zone (PGZ) of the zebrafish brain. To summarize these observations, our study establishes a strong correlation between NAC co-supplementation and restoration of DEHP-induced ER stress and neuropathology in zebrafish, but the study needs further validation to warrant the NAC-mediated potential therapeutic development against DEHP.</div></div>","PeriodicalId":422,"journal":{"name":"Science of the Total Environment","volume":"995 ","pages":"Article 180068"},"PeriodicalIF":8.2,"publicationDate":"2025-07-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144654400","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Glyphosate behavior in rice paddy fields across different rotation systems","authors":"Beatriz Alonso Vignola ,&nbsp;Angel Manuel Segura ,&nbsp;Lucía Pareja ,&nbsp;Sebastián Martínez ,&nbsp;Alvaro Roel ,&nbsp;José Terra ,&nbsp;Leonidas Carrasco-Letelier ,&nbsp;Andrés Pérez-Parada","doi":"10.1016/j.scitotenv.2025.180069","DOIUrl":"10.1016/j.scitotenv.2025.180069","url":null,"abstract":"<div><div>The intensification of irrigated rice production systems requires a comprehensive assessment of the environmental impact of pesticide use. Here, we investigated the behavior of the herbicide glyphosate (GLY) and its metabolite aminophosphonic acid (AMPA), throughout four rice rotations (continuous rice cropping (R_C), rice-soybean (R-S), rice-short term pasture (R-P_S) and rice-long term pasture R-P_L) reflecting different agricultural intensification scenarios in a long-term experimental (LTE) site.</div><div>GLY was applied twice at the same amount in all rotations as a chemical fallow and a rice pre-emergent herbicide. Application timing and frequency determined GLY and AMPA levels, but not their decay rates. GLY decay in soil differed between the non-flooded and flooded phases, fitting a first-order exponential decay in all rotations. Floodwater showed no significant differences in decay rates for the evaluated rotations. GLY concentration in soil was determined close to 200 mg kg⁻¹ whereas AMPA 600 mg kg⁻¹ ca. after 161 days post-application. During the non-flooded phase, GLY degradation in soil showed a half-life (DT₅₀) of 31.5 days. Differently, GLY and AMPA decay in floodwater followed a first-order kinetic with DT₅₀ values of approximately 5.3 and 7.4 days, respectively. GLY transference from soil to floodwater was evidenced, peaking after 8 days, followed by a significant decay in the first 39 days and negligible decay thereafter. AMPA showed the same pattern with a slower decay rate. Our findings revealed land use intensification scenarios affect background GLY levels in soil, where rice-pasture based rotations (R-P_S and R-P_L) result in lower GLY residues than R_C and R-S cropping systems. These findings hold meaningful implications, aiming at indicators and practices for defining more sustainable productive schemes and water management practices.</div></div>","PeriodicalId":422,"journal":{"name":"Science of the Total Environment","volume":"995 ","pages":"Article 180069"},"PeriodicalIF":8.2,"publicationDate":"2025-07-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144654397","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A methodology for coagulant virtual testing to improve dissolved organic matter removal in surface water treatment","authors":"Christian Ortiz-Lopez ,&nbsp;Christian Bouchard ,&nbsp;Manuel J. Rodriguez","doi":"10.1016/j.scitotenv.2025.180070","DOIUrl":"10.1016/j.scitotenv.2025.180070","url":null,"abstract":"<div><div>Coagulation is one of the most crucial steps in a Drinking Water Treatment Plant (DWTP). The coagulant dose required for the removal of particles and natural organic matter (NOM) is typically determined through jar tests. However, this method is time-consuming and not well-suited for rapid changes in raw water quality, such as those occurring during and after rainfall events. We propose a methodology for estimating the combined coagulant doses needed for NOM removal (represented by UV absorbance at 254 nm, UV₂₅₄) using a machine learning technique called Support Vector Regression (SVR) in a full-scale DWTP that does not conduct independent controls of coagulation pH. The methodology involves virtual testing of combined coagulant dose performances on UV₂₅₄ removal and coagulation pH. Performance metrics demonstrated the high capacity of the models to predict UV₂₅₄ removal and coagulation pH in the test dataset. Furthermore, our proposed methodology includes a strategy to evaluate whether the predicted coagulation pH limits residual aluminum in the produced water. The proposed framework can assist decision-making for coagulation operation practices in DWTPs.</div></div>","PeriodicalId":422,"journal":{"name":"Science of the Total Environment","volume":"995 ","pages":"Article 180070"},"PeriodicalIF":8.2,"publicationDate":"2025-07-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144654904","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Dynamic assessment of biochar soil carbon climate change impacts","authors":"M.B. Karlsson ,&nbsp;A. Kamp ,&nbsp;T.P. Thomsen","doi":"10.1016/j.scitotenv.2025.180058","DOIUrl":"10.1016/j.scitotenv.2025.180058","url":null,"abstract":"<div><div>Biochar is receiving increasing political attention as a scalable and relevant climate change mitigation tool. With this growing focus comes a growing need for more accurate assessments of biochar climate change impact potentials. The mechanism of biochar soil carbon climate change mitigation is the time offsetting of emissions through decreased soil carbon decay. Therefore, temporally dynamic modelling is necessary to accurately assess these impacts. In this study, the 100-year evolution of soil carbon following soil application of biochar, residual straw and agricultural biogas digestate is modelled considering uncertainty related to biochar stability and environmental variability. From soil carbon modelling, dynamic climate change impacts are determined for biochar, straw and digestate per unit carbon added to soil for use in life cycle assessment. The developed methods are showcased in impact assessments of biochar at two levels of systems perspective. Results show that the developed dynamic modelling methods improve the accuracy of soil carbon climate change impact assessment. By disregarding short-term soil carbon storage, static modelling underestimates the impacts of non-pyrolyzed biomass soil carbon by a factor of two to three. Biochar is shown to provide a significant net climate benefit through increased soil carbon storage. In a large-scale implementation scenario, it is shown that biochar can contribute beneficially towards the Paris agreement 2100 temperature target, but also that national emissions accounting methods and short-term political climate targets can become a barrier for political incentives to realize the climate change benefits of biochar.</div></div>","PeriodicalId":422,"journal":{"name":"Science of the Total Environment","volume":"995 ","pages":"Article 180058"},"PeriodicalIF":8.2,"publicationDate":"2025-07-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144654909","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Nanotechnology in agriculture: Innovations for sustainability and greenhouse gas mitigation-A review","authors":"Deepanjan Mridha ,&nbsp;Bishal Lamsal ,&nbsp;Joao A. Antonangelo","doi":"10.1016/j.scitotenv.2025.180065","DOIUrl":"10.1016/j.scitotenv.2025.180065","url":null,"abstract":"<div><div>Agriculture must meet the growing demand for food production while minimizing environmental impacts, particularly greenhouse gas (GHG) emissions. Nanotechnology has emerged as a promising tool with diverse applications across various sectors, including agriculture. This review highlights the application of different nano-agrochemicals in agriculture, and their role in mitigating GHG emissions. This review also outlines the advantages and risks of using nanomaterials in agriculture. The bibliometric analysis revealed a lack of integrated literature addressing the role of nanotechnology in both agricultural productivity improvement and GHG emission reduction. This underscores the importance of the present review, which brings together these two critical topics under a single framework. Compared to their conventional counterpart, nano-agrochemicals have demonstrated superior performance in enhancing plant growth, yield, and protection. Moreover, their application holds significant potential for reducing GHG emissions from the agricultural sector. However, environmental impacts of nano-agrochemicals on soil nutrient dynamics, properties, and microbial communities remain a concern. Factors such as synthesis method, physicochemical properties, dosage, and particle size significantly influence the suitability of NPs for agricultural applications. Additionally, this review underscores the importance of ecological and environmental sustainability in NP use, particularly in restoring soil microbial health and optimizing NP production for GHG reduction. By critically assessing both the benefits and potential risks of nano-agrochemicals, this review provides a balanced perspective to guide future research and the development of sustainable agricultural practices.</div></div>","PeriodicalId":422,"journal":{"name":"Science of the Total Environment","volume":"995 ","pages":"Article 180065"},"PeriodicalIF":8.2,"publicationDate":"2025-07-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144654906","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Temperature-driven body size variation is contingent on trophic position for global fishes","authors":"Adriano Caliman ,&nbsp;Guilherme Daponti ,&nbsp;Anderson da Rocha Gripp ,&nbsp;Luciana Silva Carneiro ,&nbsp;Rafael Dettogni Guariento","doi":"10.1016/j.scitotenv.2025.180052","DOIUrl":"10.1016/j.scitotenv.2025.180052","url":null,"abstract":"<div><div>Consumer energy demand increases with body size (BS) and temperature, while energy availability in food webs decreases with increasing trophic positions (TP). This suggests that thermal energetic constraints may impose more severe limits on consumer BS at high TP. Consequently, it is expected that consumers at high TP would be smaller in warmer climates because of the more severe energy limitations. We tested this hypothesis using a global dataset of 1110 marine and freshwater ray-finned fish species, while controlling for the effects of species' phylogenetic history. As predicted, fish at higher TP (predators) had significantly smaller BS in tropical aquatic ecosystems compared to temperate ones. However, contrary to our expectations, we found that tropical fish occupying lower TPs—herbivores, detritivores, and omnivores—were larger than their temperate ecological equivalents, revealing a potential thermal-trophic paradox. This contrasting pattern suggests the effect of temperature on fish BS varies with species' TP—reversing the relative BS patterns between tropical and temperate fishes along the food web. Our results were consistent across freshwater and marine fishes. These findings support the idea that larger tropical predatory fish are constrained by stronger energetic limitations leading to smaller BS, while lower-TP tropical fish may benefit from enhanced efficiency in processing plant-based diets in warmer environments. Our results are important given the role of BS as a key functional trait in structuring aquatic food webs and in understanding how global warming may influence macroecological patterns of fish BS in global aquatic ecosystems.</div></div>","PeriodicalId":422,"journal":{"name":"Science of the Total Environment","volume":"995 ","pages":"Article 180052"},"PeriodicalIF":8.2,"publicationDate":"2025-07-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144654905","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Epigenome-wide association study of gestational exposure to organophosphate esters and replacement brominated flame retardants with newborn DNA methylation","authors":"Angelico Mendy ,&nbsp;Zana Percy ,&nbsp;Joseph M. Braun ,&nbsp;Bruce Lanphear ,&nbsp;Mark J. La Guardia ,&nbsp;Robert C. Hale ,&nbsp;Scott Langevin ,&nbsp;Karl Kelsey ,&nbsp;Aimin Chen ,&nbsp;Kimberly Yolton","doi":"10.1016/j.scitotenv.2025.180079","DOIUrl":"10.1016/j.scitotenv.2025.180079","url":null,"abstract":"<div><h3>Background</h3><div>DNA methylation (DNAm) has been proposed to mediate the associations of gestational exposure to organophosphate esters (OPEs) and replacement brominated flame retardants (RBFRs) with health outcomes. However, there have not been previous epigenome-wide association studies (EWAS) on the impact of prenatal exposure to these chemicals on newborn DNAm.</div></div><div><h3>Methods</h3><div>In 252 pregnant women recruited to the Health Outcomes and Measures of Environment (HOME) Study from 2003 to 2006 in Cincinnati, Ohio, we measured the house dust concentrations of 4 OPEs and 2 RBFRs at 20 weeks of gestation and 3 urinary OPE metabolites at 16 and 26 weeks of gestation and at delivery. DNAm was assessed in newborn cord blood using the Infinium MethylationEPIC BeadChip. Multiple testing was controlled for using false discovery rate (FDR) <em>P</em>-values &lt;0.05 for significance.</div></div><div><h3>Results</h3><div>Dust tris(1,3-dichloroisopropyl) phosphate was associated with increased methylation in <em>GUK1</em> (cg12796841). Dust bis(2-ethylhexyl) tetrabromophthalate was associated with decreased methylation in <em>FAM159B</em> (cg12662072) and increased methylation in <em>ATXN10</em> (cg07527826). Dust OPEs and RBFRs were associated with differentially methylated regions (DMRs) overlapping with genes involved in parturition and emotions (<em>OXT</em>), embryogenesis (<em>HOXB</em> genes), inflammation and immunity (<em>ALOX12</em>), cell signaling (<em>LRRC34)</em>, spermatogenesis (<em>BOLL</em>), and tumorigenesis (<em>HOXB</em> genes, <em>DIP2C</em>, <em>RASSF9</em>, <em>FAM118A</em>). Urinary OPEs were associated with DMRs overlapping with DNA repair (<em>MACROD1</em>), stem cell pluripotency (<em>POU5F1</em>) and T-cell development (<em>TCL1A</em>) genes.</div></div><div><h3>Conclusions</h3><div>Prenatal OPE and RBFR exposure is associated with altered newborn DNAm. Future studies should determine if these alterations lead to disease later in life.</div></div>","PeriodicalId":422,"journal":{"name":"Science of the Total Environment","volume":"995 ","pages":"Article 180079"},"PeriodicalIF":8.2,"publicationDate":"2025-07-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144654903","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}