Science of the Total Environment最新文献

{"title":"Effects of dechlorane plus on hepatic pathology, metabolic health and gut microbiota in male mice.","authors":"Wen Liu, Qiyu He, Caiyu Yue, Tong Xu, Xiaoming Hang","doi":"10.1016/j.scitotenv.2024.177532","DOIUrl":"10.1016/j.scitotenv.2024.177532","url":null,"abstract":"<p><p>Dechlorane plus (DP), a widely used flame retardant, was added to Annex A of the Stockholm Convention on Persistent Organic Pollutants in 2023. This study aimed to investigate the effects of DP on glucose and lipid metabolism by orally exposing eight-week-old male mice to environmentally relevant concentrations of DP (0.5, 1, and 5 mg/kg/day) for six weeks. The in vivo effects of DP on liver histomorphology, glucose and lipid metabolism, intestinal microbiota, and the associated molecular mechanisms were assessed. Pathological examination revealed that exposure to 1 and 5 mg/kg/day DP induced hepatic damage, characterized by structural disarray of the hepatic cords and vacuolar degeneration of liver cells, while 0.5 and 1 mg/kg/day DP exposure led to significant triglycerides (TG) accumulation in the liver. Metabolite analysis showed a marked increase in hepatic pyruvate, glycogen, and TG in mice exposed to 0.5 and 1 mg/kg/day DP, while 5 mg/kg/day exposure resulted in elevated glycogen levels and reduced pyruvate and glucose concentrations. The underlying mechanisms involved the transcriptional regulation of key enzymes related to glucose and lipid metabolism, as well as the activation of the PI3K/AKT pathway. Exposure to 5 mg/kg/day DP upregulated genes associated with glycogenesis (GK), glycolysis (HK1 and PK), and fatty acid synthesis (SREBP1, FAS, and ACC1), while downregulating genes involved in gluconeogenesis (PCK1) and fatty acid β-oxidation (CPT1 and PPARA). The activated PI3K/AKT pathway regulated key proteins (GLUT4, GSK3β, and FoxO1), playing distinct roles in glucose and lipid metabolism. High-throughput 16S rDNA sequencing revealed that 5 mg/kg/day DP exposure altered the composition and diversity of intestinal microbiota, reducing the relative abundance of beneficial probiotics at both the phylum and genus levels. These findings offer new insights into the complex mechanisms through which DP affects glucose and lipid metabolism in mammals, contributing to a more comprehensive evaluation of its toxicity.</p>","PeriodicalId":422,"journal":{"name":"Science of the Total Environment","volume":" ","pages":"177532"},"PeriodicalIF":8.2,"publicationDate":"2024-12-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142646584","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of elevated CO₂ on the critical oxygen tension (P_crit) and aerobic metabolism of two oxygen minimum zone (OMZ) hypoxia tolerant squat lobster species.","authors":"Erika Jorquera, Antonio Brante, Ángel Urzúa, Trystan Sanders, Robert P Ellis, Rod Wilson, Mauricio A Urbina","doi":"10.1016/j.scitotenv.2024.177508","DOIUrl":"10.1016/j.scitotenv.2024.177508","url":null,"abstract":"<p><p>Marine invertebrates living in oxygen minimum zones (OMZ), where low pO₂ and high pCO₂ conditions co-occur, display physiological mechanisms allowing them to deal with these coupled stressors. We measured aerobic metabolic rate (MR_a) and the critical oxygen tension (P_crit), and calculated the oxygen supply capacity (α) of both the red (Grimothea monodon) and yellow (Grimothea johni) squat lobsters, under two pCO₂ scenarios (~414 and 1400 μatm). We also measured haemolymph pH, haemocyanin oxygen binding affinity (p₅₀), and haemolymph lactate content in both species under normoxia, low pCO₂ hypoxia and high pCO₂ hypoxia. Our results revealed that both species show extremely low P_crit and P₅₀ values. The MR_a increased under high pCO₂ condition in both species but hypoxia tolerance was not negatively impacted by pCO₂. Furthermore, hypoxia tolerance is enhanced at high pCO₂ in the yellow squat lobster, and although not statically significant, α value follows the same trend. The red squat lobster has a better pH_e regulation and lower reliance on anaerobic metabolism. While the yellow squat lobster had a poorer pH_e regulation during high pCO₂ hypoxia, relying more on anaerobic metabolism. Our research suggests that elevated pCO₂ is crucial on respiratory processes in hypoxia tolerant organisms, ameliorating the effects of hypoxia alone. Learning from OMZ adapted species contribute to better predicting climate change consequences on these important ecosystems.</p>","PeriodicalId":422,"journal":{"name":"Science of the Total Environment","volume":" ","pages":"177508"},"PeriodicalIF":8.2,"publicationDate":"2024-12-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142646597","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Salinity mediates the damage caused by acute and chronic ammonia stress in largemouth bass (Micropterus salmoides).","authors":"Lei Tang, Mengying Bian, Peng Zhang, Jun Wang","doi":"10.1016/j.scitotenv.2024.177494","DOIUrl":"10.1016/j.scitotenv.2024.177494","url":null,"abstract":"<p><p>Ammonia is a critical pollutant in aquatic environments, posing significant risks to aquaculture by accumulating in culture systems due to fish excretion and organic matter decomposition. This study investigated the effects of ammonia toxicity on juvenile largemouth bass (Micropterus salmoides) under varying salinity conditions (0 and 5 psu), focusing on physiological responses and gut microbiota changes. Results indicated that ammonia exposure led to increased mortality, oxidative stress, liver damage, and significant shifts in gut microbial communities, especially under freshwater conditions. Elevated salinity mitigated these effects by reducing the bioavailability of toxic un-ionized ammonia (UIA) and enhancing the fish's physiological resilience, particularly in the kidney and intestine. Ammonia exposure significantly increased the IBR index values in all three organs, with the gills showing the most pronounced stress response, followed by the kidney and intestine. Salinity had a significant mitigating effect by reducing the oxidative stress response in comparison to freshwater conditions. However, in the gills, the protective effect of salinity was not enough to fully counteract the oxidative stress induced by ammonia. Ammonia exposure in freshwater favored pathogenic gut bacteria genera such as Aeromonas, while higher salinity enriched stress-resistant genera like Ralstonia and Klebsiella. These findings contribute to a better understanding of the interaction between salinity and ammonia toxicity, suggesting that moderate salinity increases within the fish's tolerance range could be an effective strategy in aquaculture to reduce ammonia toxicity and promote fish health.</p>","PeriodicalId":422,"journal":{"name":"Science of the Total Environment","volume":" ","pages":"177494"},"PeriodicalIF":8.2,"publicationDate":"2024-12-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142646714","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sex-specific neurotoxicity and transgenerational effects of an emerging pollutant, tris(1,3-dichloro-2-propyl)phosphate (TDCIPP).","authors":"Debora Desantis, Yi Yang, Keng Po Lai, Rudolf S S Wu, Celia Schunter","doi":"10.1016/j.scitotenv.2024.177520","DOIUrl":"10.1016/j.scitotenv.2024.177520","url":null,"abstract":"<p><p>The growing production and usage of flame retardants (FRs) results in their extensive environmental distribution, potentially posing a threat on both ecological and human health. Tris(1,3-dichloro-2-propyl)phosphate (TDCIPP), a commonly used FR, is commonly found in aquatic ecosystems, and aquatic organisms, including fish, may be exposed to TDCIPP during specific stages of their life cycles, or across generations. Here, we aim to identify and compare the neurotoxic effects of TDCIPP on the brains of female and male adult marine medaka (Oryzias melastigma) across three generations (F0 to F3). Sex-specific effects of TDCIPP related to synaptic transmission signaling pathways and regulation of neuronal synaptic plasticity underlying 1917 differentially expressed genes (DEGs) were evident in the brain transcriptomes of F0 females, while only five DEGs were found in F0 males. However, chronic exposure over three generations (F0 to F3) revealed neurotoxic effects of TDCIPP on both sexes with males altering their innate immune response and visual perception upon prolonged exposure. Lastly, female medaka exhibited signals of transgenerational effects at the F3, as shown by increased transcriptional adjustments of 2347 DEGs including epigenetic regulatory genes. This outcome resulted from the ancestral exposure to TDCIPP only in F0, without any direct TDCIPP exposure in F1 and F2. Our findings show that even brief exposure to TDCIPP result in long-lasting effects, posing a significant risk to marine organisms and potentially other vertebrates.</p>","PeriodicalId":422,"journal":{"name":"Science of the Total Environment","volume":" ","pages":"177520"},"PeriodicalIF":8.2,"publicationDate":"2024-12-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142646715","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The role of different remaining parts of cigarette butts in the transfer of phenolic compounds into the aquatic environment and their ecological risk.","authors":"Sina Dobaradaran, Amir Salemi, Gabriel E De-la-Torre, Ursula Telgheder, Torsten C Schmidt","doi":"10.1016/j.scitotenv.2024.177584","DOIUrl":"10.1016/j.scitotenv.2024.177584","url":null,"abstract":"<p><p>Cigarette butts (CBs), the most prevalent waste material globally, have the potential to leach various toxic substances, including phenolic compounds (PhCs), into the environment and aquatic ecosystems. Nevertheless, there is a lack of knowledge concerning the long-term release of PhCs via the different parts of CBs which are littered into the environment. Hence, the present study was designed to investigate the ecological risk as well as the leachate concentrations of PhCs, including phenol, o-cresol, 2,4-dimethylphenol, pentachlorophenol and 2,3,4,6-tetrachlorophenol via different parts of CBs littered into water at several exposure times. Aged CBs collected from the environment, freshly smoked CBs, filter and paper, and remaining tobacco plus ash of freshly smoked CBs were studied to determine the leachate levels of PhCs. Pentachlorophenol and 2,3,4,6-tetrachlorophenol were not detected and quantified in the leachates of all CB types at all exposure times. The combination of filter and paper from freshly smoked CBs exhibited the highest mass-based leachate levels of phenol, o-cresol, and 2,4-dimethylphenol, whereas aged CBs showed the lowest levels. The mean leachate of phenol, o-cresol, and 2,4-dimethylphenol from all four examined CB types were in the ranges of 0.43-639.56, 0.77-58.61, and 0.25-16.58 μg L^-1 per CB, respectively. The ecological risk assessment showed that PhC leachates via all CB types had high risks for algae, Daphnia magna, and fish. The present study elucidated the release behavior of several PhCs and toxic CB-associated contaminants that have been overlooked in the literature.</p>","PeriodicalId":422,"journal":{"name":"Science of the Total Environment","volume":" ","pages":"177584"},"PeriodicalIF":8.2,"publicationDate":"2024-12-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142674829","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Toxicity of environmental chemicals in gastropods' hemocytes: Trends and insights based on investigations using Biomphalaria spp.","authors":"Gabrielly Rodrigues Leão, Luiz Phelipe Souza Silva, Luciana Damacena-Silva, Thiago Lopes Rocha","doi":"10.1016/j.scitotenv.2024.177522","DOIUrl":"10.1016/j.scitotenv.2024.177522","url":null,"abstract":"","PeriodicalId":422,"journal":{"name":"Science of the Total Environment","volume":" ","pages":"177522"},"PeriodicalIF":8.2,"publicationDate":"2024-12-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142674831","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Human activities weaken the positive effects of soil abiotic factors and biodiversity on ecosystem multifunctionality more than drought: A case study in China's West Liao River Basin.","authors":"Jirui Gong, Guisen Yang, Siqi Zhang, Weiyuan Zhang, Xuede Dong, Shangpeng Zhang, Ruijing Wang, Chenyi Yan, Tong Wang","doi":"10.1016/j.scitotenv.2024.177564","DOIUrl":"10.1016/j.scitotenv.2024.177564","url":null,"abstract":"<p><p>Watershed-scale ecosystem biodiversity has been adversely affected by human disturbances and climate change for many years, leading to degradation of ecological functions (i.e., decreased ecosystem multifunctionality, EMF). However, the driving factors and their mechanisms are unclear. Here, we analyzed the effects of human activities, climate, biodiversity, and soil abiotic factors on EMF in China's West Liao River Basin along a natural drought intensity gradient. The beneficial effects of biodiversity on EMF were influenced by the drought intensity; biodiversity increased plant density in humid zones, plant diversity in semi-arid zones, and soil microbial diversity in arid zones, thereby improving watershed EMF and indicating that drought determines the direction and strength of the effects of biodiversity on EMF. The relative abundances of soil microbial keystone taxa such as Actinomycetes and Gemmatimonadetes were the most important predictors of EMF. These results indicate that any loss of plant community diversity or plant density, soil microbial diversity, and the abundance of keystone microbial taxa could reduce EMF. Human activities and drought directly decreased EMF, but also indirectly reduced EMF by reducing soil pH and soil water content (SWC), plant diversity. As human activity increases, EMF's sensitivity to drought increases, and this implies that in regions with high levels of human activity, the effects of climate warming on EMF may be greater than expected. Overall, human activities (including direct, indirect, and total effects) are primary drivers of changes of biodiversity and soil abiotic factors in watershed ecosystems, and regulate the watershed's EMF. The results provide new insights to improve predictions of the direction, magnitude, and regulation mechanisms of EMF and its responses to global climate change.</p>","PeriodicalId":422,"journal":{"name":"Science of the Total Environment","volume":" ","pages":"177564"},"PeriodicalIF":8.2,"publicationDate":"2024-12-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142680201","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of shallow hydrothermal vent waters on monsoonal copepod distribution and abundance around active volcanic island off northeast Taiwan, West Pacific.","authors":"Anitha Mary Davidson, Li-Chun Tseng, Yan-Guo Wang, Jiang-Shiou Hwang","doi":"10.1016/j.scitotenv.2024.177711","DOIUrl":"10.1016/j.scitotenv.2024.177711","url":null,"abstract":"<p><p>Extreme oceanic environments such as shallow hydrothermal vents (HVs) have rarely been investigated with respect to their impact on the water column and its organisms, such as zooplankton. We collected mesozooplankton from the near shore shallow HV areas off northeast Taiwan during three distinct monsoonal periods in 2022. The results showed the occurrence of 99 copepod species belonging to 24 families and 49 genera from a one-year study. The results from similarity percentage (SIMPER) and indicator species analysis (IndVal) identified that top 5 species namely Temora turbinata, Oncaea venusta, Clausocalanus furcatus, Macrosetella gracilis, and Canthocalanus pauper showed variations in their abundance between HV and non-HV sites which contributed to 72.12 % dissimilarity with only four of the species with significantly higher contributions during the SW monsoon season. This distinction is explained by the fact that copepods were negatively affected by HV water. Furthermore, Temora turbinata (3530.7 ± 4967.83 ind. m^-3), Calanus sinicus (70.86 ± 163.78 ind. m^-3), and Paracalanus parvus (40.47 ± 85.67 ind. m^-3) emerging as the dominant species with a clear seasonal succession pattern during the southwest monsoon, northeast-southwest monsoon transition, and northeast monsoon prevailing phase, respectively. The total abundance of copepod was significantly higher during the southwest monsoon than during the other two monsoonal periods (p < 0.01, one-way ANOVA). In contrast, the number of species and the richness index were significantly higher during the northeast-southwest and northeast monsoon than during the southwest monsoon period (p < 0.05, one-way ANOVA) indicating temporal succession in the copepod community.</p>","PeriodicalId":422,"journal":{"name":"Science of the Total Environment","volume":"957 ","pages":"177711"},"PeriodicalIF":8.2,"publicationDate":"2024-12-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142754597","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Medical exposure to micro(nano)plastics: An exposure pathway with potentially significant harm to human health that should not be overlooked.","authors":"Xihong Qiu, Lingfan Li, Qiqi Qiu, Tianxiang Lan, Lixia Du, Xiaoqian Feng, Xuan Song","doi":"10.1016/j.scitotenv.2024.177743","DOIUrl":"10.1016/j.scitotenv.2024.177743","url":null,"abstract":"<p><p>Micro(nano)plastics (MNPs) are an emerging type of contaminants that are widely present in the environments that people live in. MNPs can enter the human body in a variety of pathways, but the three main ones are through dietary intake, air inhalation, and skin contact. However, it has been discovered that medical plastics used in medical activities also pose potential risks to MNPs exposure as exposure pathways are continuously refined and clarified. Unfortunately, there is currently insufficient study on the exposure of medical plastics and MNPs, and exposure risks and potential health problems are frequently overlooked. This study aimed to close this research gap by searching the databases of China National Knowledge Infrastructure (CNKI), PubMed, and Web of Science for relevant literature. It then filtered out publications that contained information relevant to keywords such as micro(nano)plastics, medical plastics, exposure pathways, and human health in order to do analysis and summary. We discovered that medical plastics are a high-risk source of direct MNPs exposure to the human body, and this exposure could pose a potential harm to human health. Because of the potential harm to human health, this work presents the medical exposure of MNPs for the first time and calls for more research and attention on this vital area.</p>","PeriodicalId":422,"journal":{"name":"Science of the Total Environment","volume":"957 ","pages":"177743"},"PeriodicalIF":8.2,"publicationDate":"2024-12-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142754600","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Uncovering the causal relationships in plant-microbe ecosystems: A time series analysis of the duckweed cultivation system for biomass production and wastewater treatment.","authors":"Hidehiro Ishizawa, Yosuke Tashiro, Takashi Okada, Daisuke Inoue, Michihiko Ike, Hiroyuki Futamata","doi":"10.1016/j.scitotenv.2024.177717","DOIUrl":"10.1016/j.scitotenv.2024.177717","url":null,"abstract":"<p><p>The complex interplay among plants, microbes, and the environment strongly affects productivity of vegetation ecosystems; however, determining causal relationships among various factors in these systems remains challenging. To address this issue, this study aimed to evaluate the potential of a data analytical framework called empirical dynamic modeling, which identifies causal links and directions solely from time series data. By cultivating duckweed, a promising aquatic plant for biomass production and wastewater treatment, we obtained a 63-day time series data of plant productivity, microbial community structure, wastewater treatment performance, and environmental factors. We confirmed that empirical dynamic modeling can identify the correct causal directions among temperature, light intensity and plant growth, solely from time series data. Extending the analysis to microbial community data suggested that the bacterial family Comamonadaceae positively affects host duckweed growth and nitrogen removal. Additionally, the predicted abundance of bacterial genes relevant to xenobiotics biodegradation was shown to have a positive effect on organic pollutant removal, supporting the significant role of bacterial metabolism in phytoremediation performance. These results demonstrate the effectiveness of empirical dynamic modeling in uncovering causal relationships within vegetation ecosystems, which are difficult to examine comprehensively through conventional experiment-based approaches.</p>","PeriodicalId":422,"journal":{"name":"Science of the Total Environment","volume":"957 ","pages":"177717"},"PeriodicalIF":8.2,"publicationDate":"2024-12-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142764798","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}