Science of the Total Environment最新文献

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Optimizing precision conservation with on-farm precision experiment data: The role of crop insurance and spatially variable profit 利用农场精确试验数据优化精确保护:作物保险和空间可变利润的作用
IF 8.2 1区 环境科学与生态学
Science of the Total Environment Pub Date : 2025-04-22 DOI: 10.1016/j.scitotenv.2025.179315
B. Khanal , T. Mieno , K. Schoengold , D.S. Bullock
{"title":"Optimizing precision conservation with on-farm precision experiment data: The role of crop insurance and spatially variable profit","authors":"B. Khanal ,&nbsp;T. Mieno ,&nbsp;K. Schoengold ,&nbsp;D.S. Bullock","doi":"10.1016/j.scitotenv.2025.179315","DOIUrl":"10.1016/j.scitotenv.2025.179315","url":null,"abstract":"<div><div>The study presents a land retirement framework that retires the least profitable portion of a field for conservation landcover. Our approach incorporates heterogeneity in optimal input use and profit within a field as well as impacts on crop insurance expenditures. Our approach also incorporates the potential for edge effects and changes in machinery overhead costs. Using on-farm precision experiment data from a midwestern corn field as a case study, we test our framework and compare the profit-maximizing land retirement strategy under alternative crop insurance approaches for partial-field land retirement. In our case study, optimal land retirement increases per-acre profit by $14.27, $27.95, or $32.21/acre in the no insurance, constant insurance, and adjusted insurance cases, respectively. Our general model shows that including crop insurance expenditures should increase the optimal amount of land in retirement (conservation), but the magnitude of the effect depends on the yield and profit heterogeneity within a field. In the most profitable land retirement strategy for our case study data, including crop insurance expenditures increases optimal land retirement by 3.4 %. Incorporating adjustments to average yield in crop insurance premiums generates 2.89 % ($4.26/acre) more profit compared to an estimation that ignores the impact of partial-field land retirement on yield.</div></div>","PeriodicalId":422,"journal":{"name":"Science of the Total Environment","volume":"979 ","pages":"Article 179315"},"PeriodicalIF":8.2,"publicationDate":"2025-04-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143859586","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Exposure and combined risk of pesticide mixtures in tropical wetland waters, Australia 澳大利亚热带湿地水域农药混合物的暴露和综合风险
IF 8.2 1区 环境科学与生态学
Science of the Total Environment Pub Date : 2025-04-22 DOI: 10.1016/j.scitotenv.2025.179454
Carly Beggs , Catherine Neelamraju , Sarit L. Kaserzon , Maria L. VanderGragt
{"title":"Exposure and combined risk of pesticide mixtures in tropical wetland waters, Australia","authors":"Carly Beggs ,&nbsp;Catherine Neelamraju ,&nbsp;Sarit L. Kaserzon ,&nbsp;Maria L. VanderGragt","doi":"10.1016/j.scitotenv.2025.179454","DOIUrl":"10.1016/j.scitotenv.2025.179454","url":null,"abstract":"<div><div>Located within the Great Barrier Reef Catchment Area (GBRCA), the Herbert River Floodplain is designated as an area of nationally important wetlands. Furthermore, these wetlands provide a range of critical ecosystem services which protect the Great Barrier Reef World Heritage area ecosystem from land-based effects including agricultural runoff. The surrounding intensive agricultural land use puts these wetlands at risk of excessive loading of pesticides, which may result in species decline, loss of value and reduced function of ecosystem services. The aim of this study is to investigate the combined risk from the co-occurrence of pesticides in wetlands of the Herbert River Floodplain. Waters of five freshwater wetlands were monitored for 55 pesticides using a combination of grab and passive sampling techniques between February 2021 and March 2023. The combined mixture toxicity for up to 19 commonly detected pesticide active ingredients (PAIs) was estimated using the pesticide risk metric (PRM) model, calculated as the combined percentage of species affected (PAF). Thirty-six pesticides were detected in waters across five wetlands, eight of which exceeded regulatory guidelines at least once. Site-specific species protection goals were exceeded at least once at four of the five studied wetlands. Average monthly PAF (from passive sampling) was found to be increased during the wet season, though no increase in instantaneous PAF (from grab sampling) was detected in the wet season. Our findings indicate wetlands of the broader GBRCA are likely to be at risk due to pesticide exposure, and that this risk occurs during both wet and dry seasons. Risk periods in wetlands are not consistent with those previously observed in nearby rivers and creeks and should be monitored accordingly.</div></div>","PeriodicalId":422,"journal":{"name":"Science of the Total Environment","volume":"979 ","pages":"Article 179454"},"PeriodicalIF":8.2,"publicationDate":"2025-04-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143859658","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Bio-tracking, bio-monitoring and bio-magnification interdisciplinary studies to assess cyanobacterial harmful algal blooms (cyanoHABs)’ impact in complex coastal systems 生物跟踪、生物监测和生物放大跨学科研究评估蓝藻有害藻华(cyanoHABs)对复杂海岸系统的影响
IF 8.2 1区 环境科学与生态学
Science of the Total Environment Pub Date : 2025-04-22 DOI: 10.1016/j.scitotenv.2025.179480
Germana Esposito , Teresa De Rosa , Viviana Di Matteo , Cristiano Ciccarelli , Mohammed Ajaoud , Roberta Teta , Massimiliano Lega , Valeria Costantino
{"title":"Bio-tracking, bio-monitoring and bio-magnification interdisciplinary studies to assess cyanobacterial harmful algal blooms (cyanoHABs)’ impact in complex coastal systems","authors":"Germana Esposito ,&nbsp;Teresa De Rosa ,&nbsp;Viviana Di Matteo ,&nbsp;Cristiano Ciccarelli ,&nbsp;Mohammed Ajaoud ,&nbsp;Roberta Teta ,&nbsp;Massimiliano Lega ,&nbsp;Valeria Costantino","doi":"10.1016/j.scitotenv.2025.179480","DOIUrl":"10.1016/j.scitotenv.2025.179480","url":null,"abstract":"<div><div>Cyanobacterial Harmful Algal Blooms (cyanoHABs) represent significant threats to human health and environmental sustainability. These blooms, characterized by the rapid proliferation of toxic species, can release harmful toxins into aquatic environments, with severe consequences for ecosystems and human populations. Traditional research on cyanoHABs faces several limitations, including the lack of standardized detection methods, environmental variability, and low awareness of the associated risks. Most studies rely on conventional laboratory techniques, which are often resource-intensive and not widely accessible. Additionally, the complex dynamics of cyanoHABs, influenced by factors such as temperature, nutrients, and bloom evolution, make it difficult to establish consistent regulatory and monitoring frameworks.</div><div>This paper presents a new integrated strategy that combines advanced technologies (remote sensing, in-situ multispectral analysis, mass spectrometry) with bio-monitoring and bio-tracking. This interdisciplinary approach improves the monitoring of cyanoHAB spread, tracks bioaccumulation in the food chain, and provides timely warnings for public health protection.</div><div>The case study focuses on the <em>Campi Flegrei</em> area, an active volcanic region in Southern Italy, where Lake Avernus, a volcanic lake, has experienced periodic cyanobacterial blooms. This region also hosts mussel aquaculture and recreational activities. Remote sensing allowed the tracking of the 2022 bloom from the lake to the sea, reaching a mussel farm along the coast. Rapid detection and quantification of anabaenopeptins in bivalves enabled timely alerts to local authorities, prompting an assessment of contamination risks.</div><div>The study demonstrates how the integration of remote sensing and molecular analysis enhances environmental monitoring by providing real-time, high-resolution data. This approach supports a better understanding of bloom dynamics, bioaccumulation, and impacts on the food chain, informing risk management and regulatory strategies. The research highlights the value of combining advanced technologies to improve the management of cyanoHAB-related risks, protecting both human health and ecosystem sustainability.</div></div>","PeriodicalId":422,"journal":{"name":"Science of the Total Environment","volume":"978 ","pages":"Article 179480"},"PeriodicalIF":8.2,"publicationDate":"2025-04-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143855570","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Numerical study of the effect of flow patterns on contaminant removal in a hospital ward with symmetrical and asymmetrical inlet port arrangements 对称和非对称进气口布置的医院病房内不同流型对污染物去除影响的数值研究
IF 8.2 1区 环境科学与生态学
Science of the Total Environment Pub Date : 2025-04-22 DOI: 10.1016/j.scitotenv.2025.179439
E. Martínez-Espinosa , W. Vicente , M. Salinas-Vázquez , J. Ramírez-Cruz
{"title":"Numerical study of the effect of flow patterns on contaminant removal in a hospital ward with symmetrical and asymmetrical inlet port arrangements","authors":"E. Martínez-Espinosa ,&nbsp;W. Vicente ,&nbsp;M. Salinas-Vázquez ,&nbsp;J. Ramírez-Cruz","doi":"10.1016/j.scitotenv.2025.179439","DOIUrl":"10.1016/j.scitotenv.2025.179439","url":null,"abstract":"<div><div>The effect of flow patterns on contaminant removal in a hospital ward is studied numerically using the Reynolds Averaged Navier-Stokes (RANS) approach. Transient simulations are performed for three air changes and four ventilation systems. The contaminant is represented by a tracer gas (contaminant air) to study the airflow patterns, contaminant concentration, and contaminant removal in the hospital ward. The simulation is validated through two experimental studies using different ventilation systems, yielding a satisfactory agreement between the predictions and the experimental data. Numerical results indicate that flow patterns have a significant impact on the concentration and removal of contaminants, influenced by the building's geometry and the location of injection ports. In symmetrical arrangements of injection ports, the contamination concentration tends to be non-uniform in the <em>x-z</em> directions. The contaminant removal efficiency is the lowest (0.9322–0.9877) due to jet interference and the formation of dead zones by recirculation regions. In the asymmetrical arrangement of injection ports, the formation of recirculation zones in critical areas is inhibited, resulting in a more uniform contaminant concentration compared to other cases. The contaminant removal efficiency for the nine inlet ports presents the best performance (0.9944–0.99995), as jet interference is minimized and dead zones are eliminated. Furthermore, the overall concentration is &lt;0.55 % for 9 ACH and 0.0048 % for 16 ACH in 1200 s. However, implementing more inlet ports (13) than in Case 3 affects the contaminant removal efficiency (0.9745–0.9991) due to jet interference. Therefore, according to the building geometry, a correct number of inlet ports and an appropriate distribution are essential in contaminant removal.</div></div>","PeriodicalId":422,"journal":{"name":"Science of the Total Environment","volume":"979 ","pages":"Article 179439"},"PeriodicalIF":8.2,"publicationDate":"2025-04-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143859657","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Alkalinity-salinity-sustainability: Decadal groundwater trends and its impact on agricultural water quality in the Indian Peninsula 碱度-盐度-可持续性:印度半岛地下水年代际趋势及其对农业水质的影响
IF 8.2 1区 环境科学与生态学
Science of the Total Environment Pub Date : 2025-04-22 DOI: 10.1016/j.scitotenv.2025.179459
Durga Prasad Panday , Aanchal Kumari , Manish Kumar
{"title":"Alkalinity-salinity-sustainability: Decadal groundwater trends and its impact on agricultural water quality in the Indian Peninsula","authors":"Durga Prasad Panday ,&nbsp;Aanchal Kumari ,&nbsp;Manish Kumar","doi":"10.1016/j.scitotenv.2025.179459","DOIUrl":"10.1016/j.scitotenv.2025.179459","url":null,"abstract":"<div><div>Groundwater degradation due to alkalinity and salinity threatens irrigation-dependent agriculture, particularly in the Indian Peninsula. Over-extraction, erratic monsoons, and intensive farming have worsened groundwater quality, impacting soil health and crop productivity. The study examines long-term (2002−2022) spatio-temporal variations in pH, electrical conductivity (EC), and bicarbonate (HCO₃<sup>−</sup>) datasets, integrating them with Gravity Recovery and Climate Experiment (GRACE)-derived groundwater anomalies and rainfall variability through the Standardized Precipitation-Evapotranspiration Index (SPEI) employing hierarchical clustering. It further compares these variations with irrigation indices assessing sodium (Na) hazards and water suitability to identify critical hotspots for water sustainability. From 2002 to 2022, groundwater in the Indian Peninsula has shifted towards neutral to slightly alkaline conditions, with declining alkalinity in previously high-alkaline regions (mid-Gangetic plains) and increasing salinity in arid zones. Rising EC, driven by irrigation return flows and groundwater over-extraction, alongside fluctuating HCO₃<sup>−</sup> levels, highlights the growing impact of agricultural and climatic stressors on water quality. From 2012 to 2022, groundwater levels (GWLs) declined sharply in mid-Gangetic plains due to over-extraction. The issue was further exacerbated by worsening drought conditions as revealed by SPEI. Increasing mineral undersaturation has led to rising fluoride (F<sup>−</sup>) and hardness issues, and deteriorating irrigation indices indicate worsening salinity and Na hazards. Expanding clusters of high-risk states underscore the need for targeted groundwater management strategies. Future research should explore adaptive irrigation practices and policy measures to mitigate groundwater quality decline and sustain agricultural productivity.</div></div>","PeriodicalId":422,"journal":{"name":"Science of the Total Environment","volume":"978 ","pages":"Article 179459"},"PeriodicalIF":8.2,"publicationDate":"2025-04-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143855569","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Control of atmospheric deposition and hydrodynamic conditions on black carbon distribution in coastal sediments 大气沉积控制及水动力条件对海岸沉积物中黑碳分布的影响
IF 8.2 1区 环境科学与生态学
Science of the Total Environment Pub Date : 2025-04-21 DOI: 10.1016/j.scitotenv.2025.179438
Yan Li, Fei Guo, Yang Yu, Zhao-Jing Zhang, Ji-Hua Liu
{"title":"Control of atmospheric deposition and hydrodynamic conditions on black carbon distribution in coastal sediments","authors":"Yan Li,&nbsp;Fei Guo,&nbsp;Yang Yu,&nbsp;Zhao-Jing Zhang,&nbsp;Ji-Hua Liu","doi":"10.1016/j.scitotenv.2025.179438","DOIUrl":"10.1016/j.scitotenv.2025.179438","url":null,"abstract":"<div><div>Black carbon (BC) can be introduced into marginal seas through fluvial systems or atmospheric deposition. It has raised significant concerns regarding marine ecological security, climate change, and the global carbon cycle. However, the factors controlling the spatial distribution of BC content in coastal sediments are still debated. The Shandong Peninsula coast in the North Yellow Sea is adjacent to regions with high BC emissions and lacks direct river inflow. Here, we examined the spatial distributions of BC content and its stable carbon isotopes in surface sediments of the region, aiming to elucidate their sources and drivers in coastal areas. The results reveal that the content of BC decreases in both the southward and seaward directions. The reduction in sedimentary organic carbon (SOC) content is observed only along the path of the southward coastal current. Pearson's correlation analysis between BC content and both SOC content and grain size parameters, combined with source apportionment based on δ<sup>13</sup>C values, reveals distinct sources and drivers. However, the strong correlation between BC content and finer particles is largely obscured by nearshore samples that have high BC contents. Overall, the southward decline in BC and SOC contents is predominantly influenced by regional hydrodynamic conditions, whereas the enrichment of BC in nearshore zones is attributed to atmospheric deposition from human-induced coal combustion in the adjacent regions during winter months. The significant heterogeneity in the spatial distributions of BC and SOC contents indicates that BC and OC in coastal sediments have distinct sources and fates. This finding emphasizes the importance of considering BC and OC as separate categories in both marine carbon cycling research and the assessment of the global carbon budget.</div></div>","PeriodicalId":422,"journal":{"name":"Science of the Total Environment","volume":"978 ","pages":"Article 179438"},"PeriodicalIF":8.2,"publicationDate":"2025-04-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143852360","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Dynamics and sediment transport in a path-induced blowout in opposing wind conditions 逆风条件下路径诱导井喷的动力学和泥沙输运
IF 8.2 1区 环境科学与生态学
Science of the Total Environment Pub Date : 2025-04-21 DOI: 10.1016/j.scitotenv.2025.179340
Camille René , Nicolas Robin , Thomas A.G. Smyth , Patrick A. Hesp , Antoine Lamy , Olivier Raynal , Hugues Heurtefeux
{"title":"Dynamics and sediment transport in a path-induced blowout in opposing wind conditions","authors":"Camille René ,&nbsp;Nicolas Robin ,&nbsp;Thomas A.G. Smyth ,&nbsp;Patrick A. Hesp ,&nbsp;Antoine Lamy ,&nbsp;Olivier Raynal ,&nbsp;Hugues Heurtefeux","doi":"10.1016/j.scitotenv.2025.179340","DOIUrl":"10.1016/j.scitotenv.2025.179340","url":null,"abstract":"<div><div>Blowouts play a critical role in reactivating coastal dunes by serving as sand transport corridors. While extensive studies have explored aeolian processes within blowouts under onshore and oblique wind regimes, less attention has been given to environments dominated by opposing wind directions. The Canet-en-Roussillon coastal dune (SE France) is subjected to both offshore and onshore winds, with a main blowout (B2) exhibiting a complex morphology altered by human foot traffic. This blowout was instrumented (anemometers, sediment sand traps, topographic surveys) during both offshore and onshore wind events. The study demonstrates that onshore winds, though less frequent, are the dominant morphogenic force, driving rapid landward elongation of the blowout. Multi-year analyses reveal that this elongation has facilitated the connection with a closed footpath, resulting in its elbow-shaped morphology. At event timescales, offshore winds induce minimal sediment transport due to vegetated fetch surfaces, while onshore winds promote significant sand transport and topographic variability via a bare sand fetch. Sand availability emerges as a critical factor modulating blowout evolution. The dual wind regime interacts with anthropogenic disturbances, sustaining the current morphology. Offshore winds transport sediment seaward, while the bifurcation of onshore winds by the footpath creates an internal accumulation zone, inhibiting depositional lobe formation and further elongation. These findings challenge the traditional understanding of blowouts as unidirectional sand transport corridors in dual wind environments and highlight the role of anthropogenic influences on their morphology. Further research is needed to determine whether these mechanisms are consistent across larger blowouts with higher sand volumes.</div></div>","PeriodicalId":422,"journal":{"name":"Science of the Total Environment","volume":"978 ","pages":"Article 179340"},"PeriodicalIF":8.2,"publicationDate":"2025-04-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143852041","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A comprehensive review of recent advancements in microbial-induced mineralization: biosynthesis and mechanism, with potential implementation in various environmental, engineering, and medical sectors 微生物诱导矿化的最新进展:生物合成和机制,以及在各种环境、工程和医疗领域的潜在应用
IF 8.2 1区 环境科学与生态学
Science of the Total Environment Pub Date : 2025-04-21 DOI: 10.1016/j.scitotenv.2025.179426
Marwa Eltarahony , Daniel Jestrzemski , Mohamed A. Hassan
{"title":"A comprehensive review of recent advancements in microbial-induced mineralization: biosynthesis and mechanism, with potential implementation in various environmental, engineering, and medical sectors","authors":"Marwa Eltarahony ,&nbsp;Daniel Jestrzemski ,&nbsp;Mohamed A. Hassan","doi":"10.1016/j.scitotenv.2025.179426","DOIUrl":"10.1016/j.scitotenv.2025.179426","url":null,"abstract":"<div><div>Biomineralization has garnered profuse attention in multidisciplinary fields. Using this strategy, living things, including eukaryotes or prokaryotes, mediate the uptake of ions from the surrounding environment, followed by assembling and depositing them as greatly configured structures inside the organic matrix. The generated biominerals, including nanomaterials, possess outstanding hierarchical structures that exceed their chemically synthesized counterparts. Despite the significant progress achieved in microbial-mediated mineralization, several key knowledge gaps remain, including mechanisms controlling biomineralization pathways and the impact of environmental factors on mineral morphology, crystallinity, and stability. This review provides a comprehensive description of this biomineralization, which can be categorized into controlled, influenced, and induced biomineralization. Interestingly, we highlighted biologically-induced mineralization approaches, such as photosynthesis, methane oxidation, and nitrogen-based metabolic pathways, and identified various chemical interactions during mineral production following analytical chemistry. This review also extensively delineates updates on application of biominerals across all fields, commencing with the remediation of deleterious pollutants and biominerals exploited in industrial sectors, moving on to using them to reinforce soil, generate biocement for construction, and delving into their utilization in pharmaceutical applications to deliver drugs, repair teeth and bones, and combat cancer and pathogenic microorganisms. Moreover, the review outlines the drawbacks and adequate solutions for biomineralization, particularly CaCO₃-mediated processes, such as the generation of ammonium and nitrate during the CaCO₃ precipitation process and the relatively slow rate of microbial-mediated mineralization. Biomineralization inspired the fabrication of smart biomaterials, which combine biological advantages. Overall, this comprehensive review discusses updated research and highlights potential approaches to future studies.</div></div>","PeriodicalId":422,"journal":{"name":"Science of the Total Environment","volume":"978 ","pages":"Article 179426"},"PeriodicalIF":8.2,"publicationDate":"2025-04-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143852358","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Lnc-HZ06 down-regulates HIF1α protein levels in CoCl2-exposed hypoxic trophoblast cells and villous tissues of miscarriage patients Lnc-HZ06下调cocl2暴露的流产患者缺氧滋养细胞和绒毛组织中HIF1α蛋白水平
IF 8.2 1区 环境科学与生态学
Science of the Total Environment Pub Date : 2025-04-21 DOI: 10.1016/j.scitotenv.2025.179477
Peng Tian , Jingsong Zhao , Jiarong Guo , Geng Guo , Liqin Zeng , Qiong Lei , Weina Chen , Xia Fu , Xianjie Shi , Zhongyan Xu , Depeng Zhao , Zhihong Zhang , Huidong Zhang
{"title":"Lnc-HZ06 down-regulates HIF1α protein levels in CoCl2-exposed hypoxic trophoblast cells and villous tissues of miscarriage patients","authors":"Peng Tian ,&nbsp;Jingsong Zhao ,&nbsp;Jiarong Guo ,&nbsp;Geng Guo ,&nbsp;Liqin Zeng ,&nbsp;Qiong Lei ,&nbsp;Weina Chen ,&nbsp;Xia Fu ,&nbsp;Xianjie Shi ,&nbsp;Zhongyan Xu ,&nbsp;Depeng Zhao ,&nbsp;Zhihong Zhang ,&nbsp;Huidong Zhang","doi":"10.1016/j.scitotenv.2025.179477","DOIUrl":"10.1016/j.scitotenv.2025.179477","url":null,"abstract":"<div><div>Hypoxia plays significant roles in various biological processes. In recent study, we have found that a novel lnc-HZ06 promotes the SUMOylation of HIF1α in hypoxic human trophoblast cells. Since environmental cobalt (Co) exposure causes trophoblast cell hypoxia, whether and how lnc-HZ06 might regulate the protein levels of HIF1α, an important biomarker of hypoxia, in CoCl<sub>2</sub>-exposed hypoxic trophoblast cells is still unexplored. In this study, we find that lnc-HZ06 is highly expressed in CoCl<sub>2</sub>-exposed trophoblast cells; and lnc-HZ06 further down-regulates HIF1α protein levels. In details, (1) lnc-HZ06 up-regulates METTL14 (methyltransferase-like 14) and increases m<sup>6</sup>A (N6-methyladenosine) RNA modification levels on VHL (a ubiquitin E3 ligase of HIF1α) mRNA, and thus enhances its mRNA stability and up-regulates VHL mRNA levels. (2) VHL interacts with the SUMOylated HIF1α and promotes the ubiquitination of HIF1α, and finally lnc-HZ06 promotes the ubiquitination degradation of HIF1α protein in CoCl<sub>2</sub>-exposed hypoxic trophoblast cells. Therefore, lnc-HZ06 promotes VHL-mediated HIF1α protein degradation and down-regulates HIF1α protein levels. The cellular mechanisms in hypoxic trophoblast cells were partially consistent to those in villous tissues of patients with unexplained miscarriage (UM), expect for no significantly different Co content in UM and healthy control (HC) villous tissues. Collectively, this study discovers novel regulatory roles of lnc-HZ06 and m<sup>6</sup>A modification and post-translational modification (SUMO/Ubiquitin) in HIF1α protein levels in hypoxic human trophoblast cells.</div></div>","PeriodicalId":422,"journal":{"name":"Science of the Total Environment","volume":"978 ","pages":"Article 179477"},"PeriodicalIF":8.2,"publicationDate":"2025-04-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143852359","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Development and validation of rapid technique for trace level quantification of glyphosate and AMPA in water using LC-TQ MS LC-TQ质谱快速定量水中草甘膦和AMPA技术的建立与验证
IF 8.2 1区 环境科学与生态学
Science of the Total Environment Pub Date : 2025-04-20 DOI: 10.1016/j.scitotenv.2025.179421
Subhajit Rakshit , Sumit Shekhar , Sudama Ram Sahu , Soumyajit Ghoshal , Neethu Narayanan , Neera Singh , Tirthankar Banerjee
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