Journal of Hazardous Materials最新文献

{"title":"Mechanistic insights into carbonate radical-driven reactions: Selectivity and the hydrogen atom abstraction route","authors":"Yu Li, Jun Teng, Jia Wu, Sai Zhang, Zhiwei Zhao, Li Li","doi":"10.1016/j.jhazmat.2024.136930","DOIUrl":"https://doi.org/10.1016/j.jhazmat.2024.136930","url":null,"abstract":"Carbonate radical (CO<sub>3</sub><sup>•</sup><sup><img alt=\"single bond\" src=\"https://sdfestaticassets-us-east-1.sciencedirectassets.com/shared-assets/55/entities/sbnd.gif\" style=\"vertical-align:middle\"/></sup>) is inevitably produced in advanced oxidation processes (AOPs) when addressing real-world aqueous environments, yet it often goes unnoticed due to its relatively lower reactivity. In this study, we emphasized the pivotal role of CO<sub>3</sub><sup>•<img alt=\"single bond\" src=\"https://sdfestaticassets-us-east-1.sciencedirectassets.com/shared-assets/55/entities/sbnd.gif\" style=\"vertical-align:middle\"/></sup> in targeting the elimination of contaminants by contrasting it with conventional reactive oxygen species (ROSs) and assessing the removal of sulfamethazine (SMT). Similar to singlet oxygen (<sup>1</sup>O<sub>2</sub>), CO<sub>3</sub><sup>•<img alt=\"single bond\" src=\"https://sdfestaticassets-us-east-1.sciencedirectassets.com/shared-assets/55/entities/sbnd.gif\" style=\"vertical-align:middle\"/></sup> shows a preference for electron-rich organic compounds. In addition, hydrogen atom abstraction (HAA) was determined as the primary pathway in CO<sub>3</sub><sup>•<img alt=\"single bond\" src=\"https://sdfestaticassets-us-east-1.sciencedirectassets.com/shared-assets/55/entities/sbnd.gif\" style=\"vertical-align:middle\"/></sup>-driven reactions, with a lower free energy barrier (∆G<sup>‡</sup>) compared to the addition process, while single electron transfer (SET) was found to be thermodynamically unfavorable in all selected aromatics with varying substituents, using DFT calculations. The H atoms within amino groups (<img alt=\"single bond\" src=\"https://sdfestaticassets-us-east-1.sciencedirectassets.com/shared-assets/55/entities/sbnd.gif\" style=\"vertical-align:middle\"/>NH<sub>2</sub> and <img alt=\"single bond\" src=\"https://sdfestaticassets-us-east-1.sciencedirectassets.com/shared-assets/55/entities/sbnd.gif\" style=\"vertical-align:middle\"/>NH<img alt=\"single bond\" src=\"https://sdfestaticassets-us-east-1.sciencedirectassets.com/shared-assets/55/entities/sbnd.gif\" style=\"vertical-align:middle\"/>) were shown to be the most susceptible to abstraction by CO<sub>3</sub><sup>•<img alt=\"single bond\" src=\"https://sdfestaticassets-us-east-1.sciencedirectassets.com/shared-assets/55/entities/sbnd.gif\" style=\"vertical-align:middle\"/></sup>, which is more facile than hydroxyl radical (<sup>•</sup>OH) due to the shorter N<img alt=\"single bond\" src=\"https://sdfestaticassets-us-east-1.sciencedirectassets.com/shared-assets/55/entities/sbnd.gif\" style=\"vertical-align:middle\"/>H bond cleavage length. Finally, the degradation intermediates of SMT by CO<sub>3</sub><sup>•<img alt=\"single bond\" src=\"https://sdfestaticassets-us-east-1.sciencedirectassets.com/shared-assets/55/entities/sbnd.gif\" style=\"vertical-align:middle\"/></sup> were identified, with SO<sub>2</sub> extraction, the cleavage of S<img alt=\"single bond\" src=\"https://sdfestaticassets-us-east-1.sciencedirectassets.co","PeriodicalId":361,"journal":{"name":"Journal of Hazardous Materials","volume":"31 1","pages":""},"PeriodicalIF":13.6,"publicationDate":"2024-12-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142867170","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Surveillance and environmental risk of very mobile pollutants in urban stormwater and rainwater in a water-stressed city","authors":"Francesc Labad, Sergio Santana-Viera, Jiaqi Xu, Xavier Borrell-Diaz, Marc Teixidó, Sandra Pérez","doi":"10.1016/j.jhazmat.2024.136959","DOIUrl":"https://doi.org/10.1016/j.jhazmat.2024.136959","url":null,"abstract":"Urban stormwater and rainwater in water-stressed cities serve as critical vectors for the transport and dispersion of pollutants, including very mobile compounds These pollutants, which can be influenced by factors such as land use, rainfall intensity, and urban infrastructure, pose significant risks to both human and environmental health. Although several priority pollutants have traditionally been detected in urban stormwater, little is known about the presence of very mobile compounds that may threaten urban drinking water supplies and pose environmental risks to aquatic species. In this study, 131 urban rain and stormwater samples were collected from three districts of Barcelona (Spain) and analysed for 26 very mobile pollutants that are often overlooked in conventional monitoring efforts. The findings reveal that stormwater and rainwater are major contributors to the spread of pollutants in water-stressed cities, with particular emphasis on substances like lifestyle products, pharmaceuticals, and industrial chemicals. Among the 23 compounds detected, 12 were reported for the first time to occur in urban stormwater with concentrations as high as 271<!-- --> <!-- -->µg<!-- --> <!-- -->L^-1. Measurements of dissolved organic carbon, electrical conductivity, and the presence of wastewater-borne pollutants within the correlation analysis, suggested the contribution of sanitary sewer overflows (SSO) to urban stormwater. Finally, an environmental risk assessment (worst-case scenario) was performed, showing a moderate risk of target analytes such as acesulfame and 1-naphthalenesulfonic acid (ERQ &gt; 0.1). The results highlight the need for improved surveillance systems, more sustainable stormwater management practices, and strategies for mitigating the environmental risk posed by very mobile pollutants in regions facing water scarcity.","PeriodicalId":361,"journal":{"name":"Journal of Hazardous Materials","volume":"14 1","pages":""},"PeriodicalIF":13.6,"publicationDate":"2024-12-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142867334","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Corrigendum to “An ultrasensitive liquid crystal aptasensing chip assisted by three-way junction DNA pockets for acrylamide detection in food samples” [J Hazard Mater 480 (2024) 136240–136251]","authors":"Zahra Khoshbin, Fatemeh Mohammadi, Marzieh Moeenfard, Khalil Abnous, Seyed Mohammad Taghdisi","doi":"10.1016/j.jhazmat.2024.136937","DOIUrl":"https://doi.org/10.1016/j.jhazmat.2024.136937","url":null,"abstract":"Dear Editor,","PeriodicalId":361,"journal":{"name":"Journal of Hazardous Materials","volume":"77 1","pages":""},"PeriodicalIF":13.6,"publicationDate":"2024-12-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142867332","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Simultaneous degradation of organoarsenic and immobilization of arsenate by an electroactive CuFe2O4-CNT/peroxymonosulfate platform: Insights into the distinct roles of the Cu and Fe sites","authors":"Xin Gao, Wenxiang Li, Yanbiao Liu, Hao Sun, Haitao Wang, Yi Wang","doi":"10.1016/j.jhazmat.2024.136952","DOIUrl":"https://doi.org/10.1016/j.jhazmat.2024.136952","url":null,"abstract":"Phenylarsonic acid (PAA) compounds, widely used in animal husbandry, pose a considerable environmental threat owing to their potential transformation into toxic inorganic arsenic species. To efficiently decontaminate PAA and adsorb secondary As(V), a hybrid CuFe₂O₄-modified carbon nanotube (CuFe₂O₄-CNT) filter was developed in this study. The hybrid CuFe₂O₄-CNT filter functioned as an effective catalyst, convective filtration medium, electrode, and adsorbent. Moreover, it removed 97% PAA within 80<!-- --> <!-- -->min in circulation mode under optimal conditions (25 °C, pH₀ = 7, peroxymonosulfate [PMS] = 1.5<!-- --> <!-- -->mM, and voltage = 1.0<!-- --> <!-- -->V), with a total As removal efficiency of 94%. Experimental and theoretical studies showed that the (100) and (211) planes of CuFe₂O₄-CNT contributed to PMS activation and As(V) adsorption, respectively. Quantum chemical calculations and high-performance liquid chromatography-mass spectrometry analysis determined the energy barriers for reactions between the transient state and SO₄^•− and HO^•, based on which potential PAA degradation pathways were proposed. Additionally, the negligible loss of efficiency in practical water samples and acceptable leached metal ion concentrations (Cu &lt; 0.1<!-- --> <!-- -->mg/L and Fe &lt; 0.15<!-- --> <!-- -->mg/L) confirmed the reusability and stability of the filter. This study provides a promising strategy for organoarsenic decontamination by combining electrocatalytic PMS oxidation and filtration techniques.","PeriodicalId":361,"journal":{"name":"Journal of Hazardous Materials","volume":"64 1","pages":""},"PeriodicalIF":13.6,"publicationDate":"2024-12-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142857882","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Occurrence, Seasonal Variation, and Health Risks of PM2.5-bound Liquid Crystal Monomers (LCMs) in Beijing, China","authors":"Qianling Yang, Yuwen Deng, Lirong Gao, Qiaofeng Ai, Chi Xu, Minghui Zheng","doi":"10.1016/j.jhazmat.2024.136960","DOIUrl":"https://doi.org/10.1016/j.jhazmat.2024.136960","url":null,"abstract":"Liquid crystal monomers (LCMs) are potentially persistent, bioaccumulative, and toxic emerging pollutants. However, their occurrence in outdoor PM_2.5 and related human exposure risks remain unknown. In this study, 32 composite samples were analyzed, which were prepared from daily PM_2.5 samples collected throughout the year 2021−2022 in Beijing, China. In total, fifty-six of 78 LCMs were presented at a median concentration of 66.0<!-- --> <!-- -->pg/m³ (range: 13.3 to 375.6<!-- --> <!-- -->pg/m³), with fluorinated LCMs (FBAs) predominating and accounting for 90.7% of the total LCMs. This concentration surpasses that of halogenated persistent organic pollutants (e.g., polychlorinated dibenzo-p-dioxins/furans) in ambient PM_2.5. Higher concentrations of LCMs were found in spring and summer compared to autumn and winter, which could be explained by correlations of concentrations with temperature (p &lt; 0.05). Trans,trans-3,4-Difluoro-4'-(4'-pentylbicyclohexyl-4-yl)biphenyl, trans,trans-3,4-Difluoro-4'-(4'-propylbicyclohexyl-4-yl)biphenyl, and trans,trans-3,4,5-Trifluoro-4'-(4'-propylbicyclohexyl-4-yl)biphenyl were identified for the first time as dominant compounds in ambient samples. Based on predicted biological toxicities, 48 LCMs were categorized as high priority due to their high potential for human absorption, including several compounds previously overlooked. The non-carcinogenic risks of LCMs through inhalation and dermal were negligible for children and adults. This study firstly established a priority list of LCMs in PM_2.5, highlighting the need for heightened awareness of their health risks.","PeriodicalId":361,"journal":{"name":"Journal of Hazardous Materials","volume":"64 1","pages":""},"PeriodicalIF":13.6,"publicationDate":"2024-12-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142867163","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Source-specific soil heavy metal risk assessment in arsenic waste mine site of Yunnan: integrating environmental and biological factors","authors":"Weigang Huang, Yanwei Liu, Xiaoyang Bi, Yan Wang, Huashou Li, Junhao Qin, Jingjing Chen, Zhepu Ruan, Guikui Chen, Rongliang Qiu","doi":"10.1016/j.jhazmat.2024.136902","DOIUrl":"https://doi.org/10.1016/j.jhazmat.2024.136902","url":null,"abstract":"This study quantified heavy metal (HM) pollution risks in mining site soils to provide targeted solutions for environmental remediation. Focusing on As waste mine sites in Yunnan, we utilised multiple indices and a positive matrix factorisation model to assess and quantify ecological health risks. Our ecological risk assessment distinguished between environmental and biological factors. This study demonstrated that As and Pb are the most impactful contaminants in environmental and biological contexts, respectively. Notably, the quantification of ecological risk sources indicated that agricultural sources were the main environmental influencers, accounting for 58.45% of the total impact. Consequently, Cu from agricultural sources has become a primary environmental HM target, replacing As. In the quantification of health risk sources, mining and smelting activities predominantly contributed to health risks, contributing 23% and 39.81% of the Non-Carcinogenic Risk and 47.98% and 42.96% of the Carcinogenic Risk, respectively. The representative pollution source elements As and Cd were consistent with the health risk assessment results. This study refined the ecological risk assessment framework by distinguishing between environmental and biological factors, providing crucial insights into the rehabilitation of mine sites and formulation of effective environmental management strategies.","PeriodicalId":361,"journal":{"name":"Journal of Hazardous Materials","volume":"21 1","pages":""},"PeriodicalIF":13.6,"publicationDate":"2024-12-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142867165","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The removal of high Se(IV) and Cd(II) concentrations in sulfur autotrophic reactor based on the “hibernation-like microbial survival strategy”","authors":"Ying Gao, Tingting Guo, Haibo Li, Wenli Liu, Xiaoping Wang, Yanan Hou, Zhi Chen, Jianbo Guo","doi":"10.1016/j.jhazmat.2024.136944","DOIUrl":"https://doi.org/10.1016/j.jhazmat.2024.136944","url":null,"abstract":"The removal of selenite (Se(IV)) and cadmium (Cd(II)) from low-carbon wastewater presents significant challenges. However, the addition of external organic carbon sources is limited in application due to the high cost and potential for secondary pollution. This study introduced a “hibernation-like microbial survival strategy”, enabling efficient removal of Se(IV) and Cd(II) in sulfur autotrophic reactor, with S⁰ acting as the electron donor. The removal efficiencies of 5–120 mg/L Se(IV) and 50 mg/L Cd(II) were higher than 99 % in phase I–IV, and the nanoparticles formed in sulfur autotrophic reactor were available for recycling. The analysis of X-ray photoelectron spectroscopy confirmed that the removal pathways of Se(IV) and Cd(II) were biological reduction, adsorption, and biosynthesis. The decreased ratio of actual to theoretical sulfate concentrations indicated the weakened sulfur disproportionation trend in sulfur autotrophic reactor. The formation of autotrophic-heterotrophic symbiont was beneficial for promoting electron transfer, material exchange, and information flow. Microorganisms strategically decreased metabolic activity to reduce extra energy consumption under Se(IV) and Cd(II) stress, which was manifested in the decreased extracellular DNA, extracellular polymeric substances, and electron transfer system activity. Furthermore, microorganisms reduced the secretion of nicotinamide adenine dinucleotide, cytochrome <em>c</em>, and cyt-<em>c</em> oxidase on the premise of ensuring the required electron flux. The “hibernation-like microbial survival strategy” was proposed to explain the removal of Se(IV) and Cd(II) in sulfur autotrophic reactor, expanding the potential application of sulfur autotrophy in environmental engineering.","PeriodicalId":361,"journal":{"name":"Journal of Hazardous Materials","volume":"31 1","pages":""},"PeriodicalIF":13.6,"publicationDate":"2024-12-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142867172","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Corrigendum to “Deciphering the distribution and enrichment of arsenic in geothermal water in the Red River Fault Zone, southwest China” [J Hazard Mater 485 (2025) 136756]","authors":"Sidie Zhuang, Guangcai Wang, Xiaocheng Zhou, Zheming Shi, Daoxian Yuan, Jiao Tian, Miao He, Zhaojun Zeng, Yucong Yan, Bingyu Yao, Yuwen Wang, Gaoyuan Xing, Shihan Cui","doi":"10.1016/j.jhazmat.2024.136938","DOIUrl":"https://doi.org/10.1016/j.jhazmat.2024.136938","url":null,"abstract":"The authors regret that there were some errors in the Graphical Abstract and <span><span>Fig. 7</span></span> in the above published article. The corrected figures are uploading as corrigendum. These changes will not affect the findings, discussions and conclusion of this study compared to the original version.<figure><span><img alt=\"Fig. 7\" aria-describedby=\"cap0005\" height=\"541\" src=\"https://ars.els-cdn.com/content/image/1-s2.0-S0304389424035192-gr1.jpg\"/><ol><li><span><span>Download: <span>Download high-res image (332KB)</span></span></span></li><li><span><span>Download: <span>Download full-size image</span></span></span></li></ol></span><span><span><p><span>Fig. 7</span>. Conceptual model of the genesis of hot springs in the Red River Fault Zone and the main processes controlling arsenic enrichment.</p></span></span></figure>","PeriodicalId":361,"journal":{"name":"Journal of Hazardous Materials","volume":"13 1","pages":""},"PeriodicalIF":13.6,"publicationDate":"2024-12-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142857881","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of Adaptation Time on Lincomycin Removal in Riverbank Filtration: A Long-Term Sand Column Study","authors":"Jian Zhao, Yangrui Huang, Shengchao Hu, Zhanyan Chen, Bi Chen, Weixiao Qi, Li Wang, Huijuan Liu","doi":"10.1016/j.jhazmat.2024.136950","DOIUrl":"https://doi.org/10.1016/j.jhazmat.2024.136950","url":null,"abstract":"Riverbank filtration (RBF) is an effective pretreatment technology for drinking water, removing organic micropollutants (OMPs) mainly through biodegradation. Despite documented improvements in OMP removal with extended adaptation time, the mechanisms remain poorly understood. This study assessed the removal of 128 OMPs over 82 d in a simulated RBF system, identified those with improved removal, and analyzed their properties. Additionally, microbial community shifts after 400 d of lincomycin exposure were studied to understand the underlying mechanisms. We found that the removal efficiencies of 24 OMPs, including lincomycin and fluconazole, improved by 3–77% over 82 d while being positively correlated with the presence of tertiary amides and secondary sulfonamides. Lincomycin removal efficiency rose from 20% to 95% over 68 days and stayed high. We identified eight potential degradation products of lincomycin, occurring primarily via hydroxylation, N-demethylation, and amide hydrolysis. Additionally, lincomycin notably increased the abundances of specific antibiotic-resistant bacteria (e.g., <em>Thiobacillus</em>, 8.3-fold) and ammonia-oxidizing archaea (e.g., <em>Nitrososphaera</em>, 46.8-fold). The β-lactam resistance gene in <em>Thiobacillus</em> and the <em>amo</em>A gene in <em>Nitrososphaera</em> may enhance lincomycin’s removal by promoting its hydrolysis and hydroxylation. Overall, this study provides insights into OMP biodegradation mechanisms and the impact of ng/L levels of lincomycin on microbial communities.","PeriodicalId":361,"journal":{"name":"Journal of Hazardous Materials","volume":"53 1","pages":""},"PeriodicalIF":13.6,"publicationDate":"2024-12-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142867164","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Relationships among CYP2B6 genetic variants and serum levels of multiple polychlorinated biphenyls and hydroxylated metabolites in a Japanese population","authors":"Zhaoqing Lyu, Hatasu Kobayashi, Kodai Iwase, Koichi Haraguchi, Yukiko Fujii, Kouji H. Harada","doi":"10.1016/j.jhazmat.2024.136953","DOIUrl":"https://doi.org/10.1016/j.jhazmat.2024.136953","url":null,"abstract":"Production of polychlorinated biphenyls (PCBs) has been banned since 2001 but health risks from exposure persist. PCBs are metabolized by cytochrome P450 enzymes, including CYP2B6. However, the link between <em>CYP2B6</em> gene polymorphisms and PCB metabolisms is poorly characterized. This study investigated the relationships among serum levels of major indicator PCBs and hydroxylated PCBs (OH-PCBs), which are PCB metabolites, and polymorphisms in <em>CYP2B6</em>. Blood samples (n=129) were analyzed for single nucleotide polymorphisms in <em>CYP2B6</em> (p.Q172H and p.K262R), and the corresponding haplotypes (*1, *4, *6) were determined. Concentrations of PCBs and OH-PCBs were determined using gas chromatography and mass spectrometer. Congener-specific variations in PCB metabolism were associated with different <em>CYP2B6</em> genotypes, particularly *1/*4 (hypothesized to increased expression) and *6/*6 (hypothesized to decreased expression). For certain PCBs, the *1/*4 genotype was linked to increased metabolite-to-parent compound ratios, while *6/*6 was associated with decreased ratios, as observed for PCB146 (β = 0.192, 95% CI: [0.100, 0.283], p &lt; 0.0001 for *1/*4; β = −0.235, 95% CI: [–0.366, –0.105], p = 0.001 for *6/*6). However, other PCBs, such as PCB170 and PCB183, exhibited opposite or more complex patterns. Our findings indicate intricate effects of <em>CYP2B6</em> gene polymorphisms on PCB metabolism and highlight the potential for genotype-specific risks in PCB-related toxicity.<h3>Environmental Implication</h3>PCBs are persistent in the environment and human bodies and pose potential health risks. In addition to exposure sources and levels, serum levels of PCBs largely vary in population due to difference in elimination kinetics. Cytochrome P450 are considered key enzymes for PCB metabolisms. This study demonstrated that <em>CYP2B6</em> variants, particularly *1/*4 (increased expression) and *6/*6 (decreased expression) are associated with different congener composition in serum. Furthermore, *1/*4 genotype was linked to increased metabolite-to-parent compound ratios for several PCBs, indicating the potentially significant role of <em>CYP2B6</em> in their metabolism. This study provides the first evidence suggesting that the <em>CYP2B6</em> variants in humans may contribute to population susceptibility to multiple PCB metabolites.","PeriodicalId":361,"journal":{"name":"Journal of Hazardous Materials","volume":"7 1","pages":""},"PeriodicalIF":13.6,"publicationDate":"2024-12-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142867335","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}