Journal of Hazardous Materials最新文献

{"title":"Pentachlorophenol causes energy deficiency and liver injury in marine medaka (Oryzias melastigma) through damaging mitochondria and inducing oxidative stress","authors":"Huanxin Zhang, Yu Zhang, Shixuan Cui, Lihua Cui, Jiaxin Li, Jizhuang Chu, Yumiao Zhou, Youru Zhang, Qiang Kong","doi":"10.1016/j.jhazmat.2025.138469","DOIUrl":"https://doi.org/10.1016/j.jhazmat.2025.138469","url":null,"abstract":"Pentachlorophenol (PCP) is widely distributed in marine environments and poses a threat to the health of marine organisms. Recent studies have demonstrated that PCP induces energy deficiency in marine organisms. However, the underlying toxification mechanism and the resulting adverse outcomes remain unclear. This study analyzed the energy metabolism of marine medaka (<em>Oryzias melastigma</em>) exposed to PCP at environmentally relevant concentrations via proteomic analysis and multiple physiological assessments. The results showed that PCP disrupted mitochondrial morphology, reduced mitochondrial membrane potential (MMP), and decreased adenosine triphosphate (ATP) levels in marine medaka. Proteomic analysis revealed that PCP induced oxidative stress, cytoskeletal disruption, and inhibition of the cytochrome bc1 complex and ATP synthase. These effects culminated in structural and functional impairments to mitochondria, which in turn inhibited ATP synthesis. Chronic PCP exposure led to enhanced glycolytic activity, the accumulation of liver lipids, and reduced liver function. The present study has deepened our understanding of the mechanism of PCP-induced energy production deficiency in marine fish and provides new insights into ecological risk assessment for PCP.","PeriodicalId":361,"journal":{"name":"Journal of Hazardous Materials","volume":"31 1","pages":""},"PeriodicalIF":13.6,"publicationDate":"2025-05-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143915945","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Biodegradation Characterization and Mechanism of Low-Density Polyethylene by the Enriched Mixed-Culture from Plastic-Contaminated Soil","authors":"Zhen Zhang, Xinxin Fan, Rumeng Zhang, Xinghui Pan, Xuexue Zhang, Yi Ding, Ying Liu","doi":"10.1016/j.jhazmat.2025.138530","DOIUrl":"https://doi.org/10.1016/j.jhazmat.2025.138530","url":null,"abstract":"Plastic pollution poses significant ecological and health risks. In this study, we enriched microbial consortia from plastic-contaminated soil capable of degrading low-density polyethylene (LDPE) film over a 28-day incubation period. Using two kinds of enriched cultures, the mean film weight loss rate (WLR) of 0.27 ± 0.04% (<em>p</em> &lt; 0.01) was 9 times higher than the control. Scanning electron microscopy (SEM) revealed a average hole occurrence area of 0.67 ± 0.11 μm² in the topmost sample, while the control had no change. Fourier transform infrared (FTIR) revealed specific changes in hydrophilicity (increased by 5.70 ± 0.02 times) and crystallinity (decreased by 15.73 ± 3.26%). Meanwhile, FTIR analyses including peak occurrence at 3,741<!-- --> <!-- -->cm^-1, carbonyl index and Lambert-Beer law calculations revealed moisture infiltration and predominant aldehyde carbonyl formation (88.69% in total carbonyl). The results of high-throughput sequencing indicated <em>Brevibacillus</em>, <em>Bacillus</em> and <em>Sporosarcina</em> were dominate genera in the mixed-cultures, and PICRUSt2 implied they could use LDPE as the sole carbon source. Our study aims to provided theoretical basis driving plastic degradation and to mitigate plastic pollution based on microbial resource development.","PeriodicalId":361,"journal":{"name":"Journal of Hazardous Materials","volume":"30 1","pages":""},"PeriodicalIF":13.6,"publicationDate":"2025-05-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143915367","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of micropollutant removal from artificially recharged water using activated carbon","authors":"Martina Švábová, Marek Šváb, Maryna Vorokhta, Michael Pohořelý","doi":"10.1016/j.jhazmat.2025.138504","DOIUrl":"https://doi.org/10.1016/j.jhazmat.2025.138504","url":null,"abstract":"Pilot scale micropollutant removal onto three types of granular activated carbon was tested over a period of 25 months. The columns were operated in a mode as similar as possible to the functioning of the main waterworks with the emphasis on minimizing the washing of the activated carbon layers. Sampling was performed monthly and a total of 222 micropollutants were evaluated. The columns were located at a waterworks in central Bohemia (Czech Republic). Real influent water from the river Jizera after artificial recharge and sand filtration was used. The aim of this study was to verify whether the process of micropollutant removal was suitable under the operating conditions at the waterworks.Clear seasonal patterns of micropollutant concentrations in the influent were detected. All three columns were able to effectively remove or substantially decrease the concentration of most micropollutants. The best performance was shown for the activated carbon Aquasorb 5005, which had the highest surface area and a well developed porous structure with the highest proportion of mesopores. The data were evaluated in order to identify micropollutant parameters important for their removal, and the pH-dependent octanol/water partition coefficient was identified as the key parameter. Other important parameters were charge and polar surface area of the micropollutant molecules.","PeriodicalId":361,"journal":{"name":"Journal of Hazardous Materials","volume":"95 1","pages":""},"PeriodicalIF":13.6,"publicationDate":"2025-05-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143915378","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"An AuNP-based Indicator for Rapid On-Site Detection of Strontium ion","authors":"Zhen Dong, Yanying Wang, Xianming Li, Peng Wu","doi":"10.1016/j.jhazmat.2025.138525","DOIUrl":"https://doi.org/10.1016/j.jhazmat.2025.138525","url":null,"abstract":"Strontium (Sr) has attracted significant attention due to its radioactivity and physiological toxicity. Rapid and precise detection of Sr²⁺ was critical for risk mitigation, particularly in accidents involving strontium leaks. However, the existing methods often compromise accuracy, speed, and user-friendliness, making on-site detection of Sr²⁺ challenging. Herein, we developed a gold nanoparticle (AuNP)-based indicator for Sr²⁺ through leveraging high-affinity binding between Sr²⁺ and G-quadruplex (G4) DNA to regulate the thioflavin T (ThT)-induced charge neutralization assembly of AuNPs. The proposed indicator achieved a detection limit of 2.5<!-- --> <!-- -->nM, significantly lower than the maximum allowable concentration of Sr²⁺ in drinking water (17.1<!-- --> <!-- -->μM). To enable on-site detection of Sr²⁺, we designed a self-constructed portable suitcase housing all necessary components of the indicator (~0.14 $ per test), and a smartphone app for colorimetric analysis. The proposed indicator was successfully explored for on-site detection of Sr²⁺ in rivers across Chengdu, Kunming, and Xishuangbanna, China, demonstrating its reliability for environmental monitoring.","PeriodicalId":361,"journal":{"name":"Journal of Hazardous Materials","volume":"3 1","pages":""},"PeriodicalIF":13.6,"publicationDate":"2025-05-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143915747","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A framework for spatial correlations between industrial pollution sources and groundwater vulnerabilities based on machine learning and spatial cluster analysis: implications for risk control","authors":"Rui Zhou, Jian Chen, Haobo Bian, Lu Li, Tao Zhang, Lei Liao, Haobo Niu, Leyi Yin, Guoxin Huang","doi":"10.1016/j.jhazmat.2025.138492","DOIUrl":"https://doi.org/10.1016/j.jhazmat.2025.138492","url":null,"abstract":"The efficacy of groundwater pollution risk control is often limited by a lack of information on spatial correlations between industrial pollution sources and groundwater vulnerabilities. To overcome this limitation, a novel data-driven framework was established to reveal the spatial correlations between industrial pollution sources and groundwater vulnerabilities in Guangdong Province, China, mainly using a combination of genetic algorithm (GA), back propagation neural network (BPNN), kernel density estimation (KDE) and bivariate local Moran’s I (BLMI). The subjectivity in the indicator weighting of a DRASTICL model was successfully reduced by GA-BPNN, and then the groundwater vulnerability map was created by the GA-BPNN-DRASTICL model. A smoother surface of the industrial pollution source distribution was produced by KDE. The spatial clustering map between industrial pollution sources and groundwater vulnerabilities was generated by BLMI, explicitly showing their distribution characteristics and implying that the specific measures should be taken for controlling risks of groundwater pollution in the different parts of the study area.","PeriodicalId":361,"journal":{"name":"Journal of Hazardous Materials","volume":"47 1","pages":""},"PeriodicalIF":13.6,"publicationDate":"2025-05-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143915760","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Simultaneous Adsorption and Hydrolysis of Insensitive Munition Compounds by Pyrogenic Carbonaceous Matter (PCM) and Functionalized PCM in Soils","authors":"Nourin I. Seenthia, Wael Abdelraheem, Samuel A. Beal, Joseph J. Pignatello, Wenqing Xu","doi":"10.1016/j.jhazmat.2025.138501","DOIUrl":"https://doi.org/10.1016/j.jhazmat.2025.138501","url":null,"abstract":"Military training with insensitive munitions (IM) deposits a large amount of post-detonation residues on range soils that may contaminate groundwater. This study investigated the effectiveness of pyrogenic carbonaceous matter (PCM) and functionalized PCM as a soil amendment to retain and transform IM compounds (e.g., 5-nitro-1,2-dihydro-3H-1,2,4-triazin-3-one (NTO), nitroguanidine (NQ), and 2,4-dinitroanisole (DNAN)). Initial hydrolysis tests showed quaternary ammonium (QA)-modified PCM accelerated NQ hydrolysis, while NTO formed charge-assisted hydrogen bonds with PCM's surface groups instead of hydrolyzing. We amended three soils with a subset of PCM materials and monitored the removal of NTO, NQ, and DNAN under varying pH conditions (i.e., 8.0,10.0, and 12.0) and amendment dosages (i.e., 0, 2, 3, and 5% (w)) in batch reactors. We also assessed the reactivity and reusability of the best-performing PCM by consecutive addition of IM post-detonation residues. Our results indicate that PCM can significantly enhance the removal of NTO, NQ, and DNAN in soils by 50 to 300-fold compared to soil controls, and QA-modified activated carbon (AC) performed the best. Increasing pH from 8.0 to 10.0 enhanced the DNAN hydrolysis with PCM, whereas NQ hydrolysis only occurred at pH 12.0. However, increasing PCM dosage from 2 to 5% (w) did not significantly increase the removal of NTO, NQ, and DNAN. QA-modified AC maintained its reactivity over three consecutive additions of IM post-detonation residues at pH 10.0, with an average NTO and NQ removal of 98.8±0.6% and 84.2±3.2%, respectively, and DNAN decay of 55.3±2.9%. Overall, our findings highlight the effectiveness of the functionalized PCM in simultaneously retaining and transforming IM compounds, providing a strategy for using reactive amendment <em>in-situ</em> to sustain military operation and mitigate pollution.<h3>Environmental Implication</h3>PCMs have been used to remove contaminants from the solution by adsorption and/or complexation, but not to bring about their degradation. Evidence presented herein showed for the first time that PCM not only adsorbs but also promotes the hydrolysis of DNAN and NQ, thus significantly reducing the need for material regeneration. Unlike traditional carbon amendments, DNAN and NQ degradation on carbon surfaces will free up adsorption sites, allowing the tailored carbon to sequester them continuously. Any munitions, such as NTO, that are not susceptible to hydrolysis, can be safely entrapped within the amendment, decreasing their bioavailability from the surrounding environment.","PeriodicalId":361,"journal":{"name":"Journal of Hazardous Materials","volume":"5 1","pages":""},"PeriodicalIF":13.6,"publicationDate":"2025-05-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143915376","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Region-specific characterization and ecotoxicity assessment of PAH compounds in winter PM2.5 from three capital cities in Northeast Asia","authors":"Min Sung Kim, Seulgidaun Lee, Moonhee Park, Hyemi Jang, Mira Choi, Ji Yi Lee, Mijung Song, Changhyuk Kim, Junyoung Ahn, Zhijun Wu, Amgalan Natsagdorj, Jungju Seo, Tae Kwon Lee, Young Hwan Kim, Kyoung-Soon Jang","doi":"10.1016/j.jhazmat.2025.138536","DOIUrl":"https://doi.org/10.1016/j.jhazmat.2025.138536","url":null,"abstract":"Industrialization and urbanization in Northeast Asia have heightened PM_2.5 pollution, posing significant public health risks. This study examined the spatial and chemical variability of polycyclic aromatic hydrocarbons (PAHs) and their ecotoxicity in winter PM_2.5 from three capitals—Ulaanbaatar (UB, Mongolia), Beijing (BJ, China), and Seoul (SE, South Korea)—using two-dimensional gas chromatography time-of-flight mass spectrometry (GC×GC-TOF MS). PM_2.5 samples collected between December 15, 2020 and January 14, 2021 revealed UB had the highest concentrations (85.7 ± 36.7<!-- --> <!-- -->μg<!-- --> <!-- -->m^-3) and PAH levels (758.9 ± 224.7<!-- --> <!-- -->ng<!-- --> <!-- -->m^-3), primarily from coal combustion and biomass burning. BJ (30.3 ± 16.9<!-- --> <!-- -->μg<!-- --> <!-- -->m^-3; 41.4 ± 18.4<!-- --> <!-- -->ng<!-- --> <!-- -->m^-3) and SE (26.0 ± 14.4<!-- --> <!-- -->μg<!-- --> <!-- -->m^-3; 6.2 ± 2.4<!-- --> <!-- -->ng<!-- --> <!-- -->m^-3) had lower PAH levels but a higher share of secondary products, including oxygenated (OPAHs) and nitrogen-containing PAHs (NPAHs). Overall, 646 PAH compounds were identified: UB was dominated by methylated alkyl and sulfur-containing PAHs, while BJ and SE had more hydroxylated and carbonylated PAHs. QSAR ecotoxicity analysis indicated the highest toxicity in SE from hydroxylated PAHs and a broader toxic range in UB. These findings support air quality strategies to reduce coal combustion in UB and secondary PAH formation in BJ and SE.","PeriodicalId":361,"journal":{"name":"Journal of Hazardous Materials","volume":"14 1","pages":""},"PeriodicalIF":13.6,"publicationDate":"2025-05-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143915377","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Formation of metal-microplastic complexes in lung adenocarcinoma is associated with increased risk of cancer progression","authors":"Runze Liu, Xiaokang Guo, Guangjian Yang, Shuangqing Lu, Feihu Chen, Wenxiao Jia, Ji Li, Jiling Niu, Hongbo Guo, Hui Zhu","doi":"10.1016/j.jhazmat.2025.138517","DOIUrl":"https://doi.org/10.1016/j.jhazmat.2025.138517","url":null,"abstract":"Metal-microplastic complexes (m-MPs) represent an emerging environmental health concern. However their presence and pathological implications in lung adenocarcinoma (LUAD) remain underexplored. This study employed a multimodal approach to characterize m-MPs in 15 LUAD patients, integrating several techniques, including laser direct infrared imaging (LDIR), pyrolysis gas chromatography-mass spectrometry (Py-GCMS), inductively coupled plasma analysis (ICP), and Sequencing at the transcriptome level. Totally, 34 distinct microplastic types were identified in lung tissues, with polyvinyl chloride (PVC) predominant in tumor tissues. Notably, the levels of aluminum (Al) and calcium (Ca) exhibited strong positive correlations with microplastics (MPs) content in tumors (<em>p</em>&lt;0.05). In this study, a novel approach was applied to assess the influences of m-MPs on tumor, through which we found that m-MPs accumulation could activate pro-tumorigenic pathways, leading to reduced overall survival (HR=1.59, <em>p</em>=0.002) and disease-specific survival (HR=1.64, <em>p</em>=0.01). Moreover, SYNE1 and RORA genes were identified as diagnostic/prognostic biomarkers for the assessment of m-MPs exposure in LUAD. Our findings revealed that m-MPs have the capacity for promoting metal ion deposition and oncogenic signaling, thereby involved in LUAD progression. This work also provides evidence using human tissue to demonstrate the association of m-MPs with lung cancer outcomes and advocate the development and application of therapeutic strategies targeting m-MPs.","PeriodicalId":361,"journal":{"name":"Journal of Hazardous Materials","volume":"13 1","pages":""},"PeriodicalIF":13.6,"publicationDate":"2025-05-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143915753","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Biotransformation of iron oxide nanoparticles and their impact on biokinetics in rats after the intratracheal instillation","authors":"Jiyoung Jeong, Songyeon Kim, Muruganantham Rethinasabapathy, Yu-Jeong Yang, Yun Suk Huh, Wan-Seob Cho","doi":"10.1016/j.jhazmat.2025.138518","DOIUrl":"https://doi.org/10.1016/j.jhazmat.2025.138518","url":null,"abstract":"Understanding the biokinetics of inhaled nanomaterials is essential for evaluating their potential adverse effects, yet current analytical methods may not account for biotransformation—where nanoparticles are transformed into new particle types. This study compared the biokinetics of partially soluble Fe₂O₃ and poorly soluble TiO₂ to investigate how biotransformation influences lung clearance kinetics. Test nanoparticles (140<!-- --> <!-- -->µg/rat) were instilled into the lungs of rats, and quantitative and qualitative assessments were performed on samples collected from the lungs on days 0, 1, 7, 14, 28, and 90 post-instillation. Notably, this study focused on the biokinetics of particulate forms within the lungs to specifically address particokinetics. Fe₂O₃ exhibited biphasic clearance kinetics, with rapid clearance in the early phase (days 0 to 14; half-life of 13 days) and slow clearance in the late phase (days 14 to 90; half-life 123 days). This biphasic pattern was attributed to the erosion of Fe₂O₃ into smaller, nanometer-sized particles, approximately 40% of which persisted in the lungs for over 3 months. These retained particles showed reduced oxidative potential and were sequestered in ferritin protein, mitigating potential toxicity. In contrast, TiO₂ exhibited a monophasic clearance pattern with a half-life of 88 days and did not exhibit particle degradation. These findings underscore the critical role of biotransformation in understanding the long-term safety and toxicity of inhaled nanomaterials, highlighting the need for comprehensive studies to assess their biological fate and potential risks. Further research should focus on potential adverse effects due to particle overload, interactions with biomolecules, and disruptions in metal homeostasis.","PeriodicalId":361,"journal":{"name":"Journal of Hazardous Materials","volume":"35 1","pages":""},"PeriodicalIF":13.6,"publicationDate":"2025-05-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143910715","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"TBBPA induced hepatocyte ferroptosis by PCBP1-mediated ferritinophagy","authors":"Rui-Qi Liu, Yu-Tong Wu, Yue Cheng, Yuan-Hang Chang, Muhammad Asmat Ullah Saleem, Zi-Yan Hu, Shang-Jia Yang, Xue-Qi Wang, Yi-Jia Song, Xin-Yue Mao, Jing Zheng, Yi-Bo Wang, Ming Lou, Yi Zhao, Jin-Long Li","doi":"10.1016/j.jhazmat.2025.138515","DOIUrl":"https://doi.org/10.1016/j.jhazmat.2025.138515","url":null,"abstract":"Tetrabromobisphenol A (TBBPA) is the most widely used brominated flame retardant and has been identified as emerging widespread pollutants. Ferroptosis, a recently characterized form of iron-dependent cell death, is related to a wide range of liver diseases. Ferritinophagy as a novel selective form of autophagy functions in iron processing is essential to induce ferroptosis. Poly(rC)-binding protein 1 (PCBP1) is an iron chaperone involved in iron loading to ferritin. Nevertheless, the potential health risk caused by TBBPA in mammals is unknown. Thus, this study is conducted to explore the molecular mechanism of TBBPA-induced liver injury and the unique role of PCBP1 in it. In this study, we found that TBBPA exposure caused hepatic pathological injury and hepatocyte mitochondrial morphological changes, such as decreased or absent mitochondrial crest, ruptured mitochondrial membranes and mitochondrial shrinkage. The result showed that TBBPA exposure exacerbated glutathione depletion and lipid peroxidation, which are hallmarks of ferroptosis. Consistent with the results in vivo, TBBPA exposure activated ferritinophagy and upregulated indicators related to ferroptosis in hepatocytes. Of note, overexpression of PCBP1 inhibited TBBPA-induced ferroptosis by reducing overstimulated ferritinophagy. Here, we uncover a new mechanism whereby TBBPA triggers hepatocyte ferroptosis through the activation of ferritinophagy. Of note, we identify PCBP1 as critical for liver iron homeostasis, link this molecule to liver disease. Taken together, our findings provide a new therapeutic strategy and potential target for the treatment of liver disease.","PeriodicalId":361,"journal":{"name":"Journal of Hazardous Materials","volume":"31 1","pages":""},"PeriodicalIF":13.6,"publicationDate":"2025-05-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143910724","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}