Journal of Hazardous Materials最新文献_第10页

Experimental Raman Spectra Analysis of Selected PFAS Compounds: Comparison with DFT Predictions 选定PFAS化合物的实验拉曼光谱分析：与DFT预测的比较

IF 13.6 1区环境科学与生态学

Journal of Hazardous Materials Pub Date : 2025-05-21 DOI: 10.1016/j.jhazmat.2025.138704

Amit Kumar, Joshua C. Rothstein, Yangxiu Chen, Hong Zhang, Yiping Zhao

{"title":"Experimental Raman Spectra Analysis of Selected PFAS Compounds: Comparison with DFT Predictions","authors":"Amit Kumar, Joshua C. Rothstein, Yangxiu Chen, Hong Zhang, Yiping Zhao","doi":"10.1016/j.jhazmat.2025.138704","DOIUrl":"https://doi.org/10.1016/j.jhazmat.2025.138704","url":null,"abstract":"PFAS are persistent environmental pollutants with significant health implications, necessitating precise detection and characterization methods. This study employs Raman spectroscopy, supplemented by density functional theory (DFT) calculations, to investigate the vibrational spectroscopic properties of nine PFAS compounds with varying chain lengths and functional groups. Experimental Raman spectra revealed distinct vibrational peaks across low, medium, high, and ultra-high wavenumber regions, enabling differentiation based on molecular structure. DFT calculations provided detailed mode assignments and validated experimental observations, highlighting chain length and functional group-dependent spectral shifts. Additionally, using principal component analysis (PCA) and t-distributed stochastic neighbor embedding (t-SNE), the Raman spectra of 9 PFAS compounds can be clustered and separated well, revealing both structural similarities and unique functional group influences. The integration of experimental, computational, and data-driven methodologies demonstrates the potential of Raman spectroscopy as a robust tool for PFAS detection and differentiation. These findings enhance the spectral database for PFAS compounds and offer valuable insights for environmental monitoring and contamination analysis.","PeriodicalId":361,"journal":{"name":"Journal of Hazardous Materials","volume":"45 1","pages":""},"PeriodicalIF":13.6,"publicationDate":"2025-05-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144114369","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Measurement and modelling of sorbent-amendment impacts on seasonal and long-term PFAS transport through unsaturated soil lysimeters 通过非饱和土壤溶渗仪测定和模拟吸收剂对PFAS季节性和长期迁移的影响

IF 13.6 1区环境科学与生态学

Journal of Hazardous Materials Pub Date : 2025-05-21 DOI: 10.1016/j.jhazmat.2025.138662

Michel Hubert, Björn Bonnet, Sarah E. Hale, Erlend Sørmo, Gerard Cornelissen, Lutz Ahrens, Hans Peter H. Arp

{"title":"Measurement and modelling of sorbent-amendment impacts on seasonal and long-term PFAS transport through unsaturated soil lysimeters","authors":"Michel Hubert, Björn Bonnet, Sarah E. Hale, Erlend Sørmo, Gerard Cornelissen, Lutz Ahrens, Hans Peter H. Arp","doi":"10.1016/j.jhazmat.2025.138662","DOIUrl":"https://doi.org/10.1016/j.jhazmat.2025.138662","url":null,"abstract":"This study investigated the effectiveness of waste-derived biochar amendments and commercial sorbents in stabilizing PFAS-spiked soils in field-scale in situ lysimeters over nearly one year under seasonal changes in Sweden. All tested sorbent amendments reduced average PFAS leachate concentrations by over 99% for long-chain and 83–96% for short-chain PFCAs and PFSAs, even under fluctuating water levels. Sewage sludge-derived biochar performed comparably to tested commercial sorbents. Long-chain PFAS remained evenly distributed in the soil, while short-chain PFAS accumulated in lower sections due to higher mobility. Higher PFAS leaching occurred in the spring due to snowmelt events and during summer months due to heavy rainfall. A 1D-transport model was developed to derive retardation factors and identify the fraction sorbed at the air-water interface before and after treatment, as well as PFAS leaching over 100 years. In no-sorbent lysimeters, 30–65% of perfluorooctane sulfonate (PFOS) was retained at the air-water interface, with seasonal variations of up to 20%. Inclusion of the sorbent reduced air-water interface effects, as solid-phase sorption became dominant. Over 100 years, nearly all PFOS are predicted to leach from no-sorbent lysimeters, while less than 1% will leach from soil treated with sewage sludge derived biochars. Such sorbent amendment can be integrated into ongoing remediation projects.","PeriodicalId":361,"journal":{"name":"Journal of Hazardous Materials","volume":"18 1","pages":""},"PeriodicalIF":13.6,"publicationDate":"2025-05-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144114371","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Rising Tide to Silent Tsunami: Unveiling the Role of Plastics in Driving Antimicrobial Resistance 涨潮到无声海啸：揭示塑料在推动抗菌素耐药性中的作用

IF 13.6 1区环境科学与生态学

Journal of Hazardous Materials Pub Date : 2025-05-21 DOI: 10.1016/j.jhazmat.2025.138700

Emily M Stevenson, Angus Buckling, Matthew Cole, Penelope K Lindeque, Aimee K Murray

引用次数: 0

Iron-silicon modified biochar for remediation of cadmium/arsenic co-contaminated paddy fields: is it possible to kill two birds with one stone? 铁硅改性生物炭修复镉砷共污染稻田：能否一举两得？

IF 13.6 1区环境科学与生态学

Journal of Hazardous Materials Pub Date : 2025-05-21 DOI: 10.1016/j.jhazmat.2025.138702

Han Wu, Linan Liu, Jingmin Sun, Xin He, Zichuan Li, Jingchun Tang

{"title":"Iron-silicon modified biochar for remediation of cadmium/arsenic co-contaminated paddy fields: is it possible to kill two birds with one stone?","authors":"Han Wu, Linan Liu, Jingmin Sun, Xin He, Zichuan Li, Jingchun Tang","doi":"10.1016/j.jhazmat.2025.138702","DOIUrl":"https://doi.org/10.1016/j.jhazmat.2025.138702","url":null,"abstract":"Biochar remediation reduces Cd pollution via adsorption but potentially increases As accumulation in rice grains by microbial reduction. Thus, developing materials that simultaneously adsorb Cd and inhibit As translocation to plants is crucial. Iron-silicon modified biochar (Fe/Si-BC) was synthesized and evaluated in pot experiments for remediation of Cd/As co-contamination. The results demonstrated that the Fe/Si-BC significantly reduced Cd accumulation in rice grains by up to 81.12%. Mantel test analysis and random forest importance analysis revealed that the Fe and dissolved Si introduced by the Fe/Si-BC were key factors in reducing Cd bioavailability, highlighting the synergistic roles of Fe and Si in increasing remediation efficiency. Notably, Fe/Si-BC exhibited dual effects on As toxicity in the rice. Specifically, in the high-pollution soils, 0.35% Fe/Si-BC significantly reduced As accumulation in the rice grains by 28.21%. In contrast, the 1.0% Fe/Si-BC slightly increased As accumulation in the rice grains. Unfortunately, Fe/Si-BC increased the risk of As release into porewater. Further analysis revealed that the Fe/Si-BC promoted the formation of iron plaques, which possessed a pronounced affinity for As, thereby substantially diminishing As uptake by the rice roots. Overall, this study highlights the potential of Fe/Si-BC for the remediation of Cd/As co-contaminated soils, while emphasizing the need for application to manage As mobility risks.","PeriodicalId":361,"journal":{"name":"Journal of Hazardous Materials","volume":"15 1","pages":""},"PeriodicalIF":13.6,"publicationDate":"2025-05-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144114374","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Wastewater-borne pollutants influenced antibiotic resistance genes and mobile genetic elements in the soil without affecting the bacterial community composition in a changing wastewater irrigation system 废水污染物对土壤中抗生素抗性基因和移动遗传因子的影响不影响污水灌溉系统中细菌群落的组成

IF 13.6 1区环境科学与生态学

Journal of Hazardous Materials Pub Date : 2025-05-21 DOI: 10.1016/j.jhazmat.2025.138680

Leila Soufi, Ioannis D. Kampouris, Kathia Lüneberg, Benjamin J. Heyde, Dipen Pulami, Stefanie P. Glaeser, Christina Siebe, Jan Siemens, Kornelia Smalla, Elisabeth Grohmann, Sara Gallego

{"title":"Wastewater-borne pollutants influenced antibiotic resistance genes and mobile genetic elements in the soil without affecting the bacterial community composition in a changing wastewater irrigation system","authors":"Leila Soufi, Ioannis D. Kampouris, Kathia Lüneberg, Benjamin J. Heyde, Dipen Pulami, Stefanie P. Glaeser, Christina Siebe, Jan Siemens, Kornelia Smalla, Elisabeth Grohmann, Sara Gallego","doi":"10.1016/j.jhazmat.2025.138680","DOIUrl":"https://doi.org/10.1016/j.jhazmat.2025.138680","url":null,"abstract":"Over decades, untreated wastewater from Mexico City was used to irrigate crops in the Mezquital Valley. With the construction of a wastewater treatment plant (WWTP), irrigation was replaced by WWTP effluent. To investigate how this shift affects the abundance, diversity, and dispersion of antibiotic resistance genes (ARGs) and mobile genetic elements (MGEs) in the short-term, we conducted a soil microcosm experiment over 4 weeks. Soils from the Mezquital Valley with a long history of irrigation with untreated wastewater were irrigated with WWTP influent or effluent, both spiked with or without antibiotics and disinfectants. The spiking of irrigation water increased water-extractable soil concentrations of sulfamethoxazole. ARG and MGE abundances were affected by the spiking, whereas soil type and water quality had no effect. Contrarily, the soil microbiome was only determined by the soil type and the duration of incubation. Among the most abundant soil amplicon sequence variants (ASVs), one affiliated to Pseudomonas was affected by the spiking. Two ASVs affiliated to Methylotenera detected among the most abundant in wastewater and soil increased in abundance in soil after wastewater irrigation, indicating that they were likely introduced with the irrigation water or benefited from it. Most isolates from WWTP influent or effluent belonged to proteobacterial genera. These findings highlight the importance of water pollution on the dissemination and spread of ARGs.","PeriodicalId":361,"journal":{"name":"Journal of Hazardous Materials","volume":"11 1","pages":""},"PeriodicalIF":13.6,"publicationDate":"2025-05-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144104290","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Paper-based SERS Chip with Adaptive Attention Neural Network for Pathogen Identification 基于纸张的自适应注意神经网络SERS芯片用于病原体识别

IF 13.6 1区环境科学与生态学

Journal of Hazardous Materials Pub Date : 2025-05-21 DOI: 10.1016/j.jhazmat.2025.138694

Liyan Bi, Huangruici Zhang, Chenyu Mu, Kaidi Sun, Hao Chen, Zhiyang Zhang, Lingxin Chen

{"title":"Paper-based SERS Chip with Adaptive Attention Neural Network for Pathogen Identification","authors":"Liyan Bi, Huangruici Zhang, Chenyu Mu, Kaidi Sun, Hao Chen, Zhiyang Zhang, Lingxin Chen","doi":"10.1016/j.jhazmat.2025.138694","DOIUrl":"https://doi.org/10.1016/j.jhazmat.2025.138694","url":null,"abstract":"High-speed and accuracy identification of pathogens has become increasingly critical in both individual patient care and public health. Artificial intelligence (AI)-assisted surface-enhanced Raman scattering (SERS) biosensors enable simultaneous identification of multiple pathogens. However, there are still problems such as low accuracy and limited diversity in bacterial fingerprints. To this end, we present a novel multi-branch adaptive attention convolutional neural network (MBAA-CNN)-assisted paper-based SERS chip for prompt and reliable pathogen discrimination. In the approach, we employed a dual-function molecule 4-mercaptophenylboronic acid (4-MPBA) to capture bacteria and enhance Raman spectra diversity, referring as 4-MPBA labeled mode (label mode). Meanwhile, we utilized the K-means algorithm to identify pathogens in the label mode, producing much higher accuracy compared to label-free mode (n = 2,000). Furthermore, we acquired 98.6% accuracy at all pathogen species and 99.5% accuracy at the antibiotic-resistant and sensitive strains (n = 10,000) using MBAA-CNN. The superior performance of MBAA-CNN was further validated through comparisons with traditional machine learning models, particularly in terms of loss value, speed and accuracy. We envision the developed approach has potential for early culture-free diagnosis of pathogens and real-time monitoring of microbial contamination in water environment.","PeriodicalId":361,"journal":{"name":"Journal of Hazardous Materials","volume":"35 1","pages":""},"PeriodicalIF":13.6,"publicationDate":"2025-05-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144114373","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Impact of microplastics exposure on the reconfiguration of viral community structure and disruption of ecological functions in the digestive gland of Mytilus coruscus 微塑料暴露对贻贝（Mytilus coruscus）消化腺病毒群落结构重构和生态功能破坏的影响

IF 13.6 1区环境科学与生态学

Journal of Hazardous Materials Pub Date : 2025-05-20 DOI: 10.1016/j.jhazmat.2025.138692

Xinjie Liang, Bin Li, Xiangli Dong, Xinyu Zhao, Hongfei Li, Yingying Ye, Haiping Ma, Suzhen Ran, Jiji Li

{"title":"Impact of microplastics exposure on the reconfiguration of viral community structure and disruption of ecological functions in the digestive gland of Mytilus coruscus","authors":"Xinjie Liang, Bin Li, Xiangli Dong, Xinyu Zhao, Hongfei Li, Yingying Ye, Haiping Ma, Suzhen Ran, Jiji Li","doi":"10.1016/j.jhazmat.2025.138692","DOIUrl":"https://doi.org/10.1016/j.jhazmat.2025.138692","url":null,"abstract":"Microplastics (MPs) pose ecological risks by serving as viral vectors and disrupting host microbiomes. This study investigated the impact of MPs on the digestive gland virome of Mytilus coruscus through an in situ exposure experiment on Xixuan Island, Zhoushan, China, using polyethylene MPs and metagenomic sequencing. MPs biofilms were dominated by lytic viruses (> 99%) with low diversity (Shannon index = 4.10 ± 0.39), whereas digestive glands harbored a more diverse virome (Shannon index = 7.26 ± 1.26). MPs ingestion significantly reduced virome diversity and altered viral community composition. Functional analysis showed that MPs biofilms were enriched in genes related to genetic processing, carbohydrate metabolism and membrane biogenesis, while transcription- and replication-related genes declined (P < 0.05) in digestive glands post-ingestion. MPs biofilms carried abundant antibiotic resistance genes (ARGs) and virulence factors, selectively enriching multidrug resistance genes (efrA, patB) while reducing functional viral gene abundance. Metal (Zn, Hg, As) and biocide resistance genes were prevalent in MPs biofilms but declined post-ingestion. Additionally, MPs ingestion weakened microbial network stability, potentially impairing immune regulation and metabolic homeostasis. These findings underscore MPs’ role in shaping viral communities and spreading resistance genes, heightening ecological risks in marine environments.","PeriodicalId":361,"journal":{"name":"Journal of Hazardous Materials","volume":"135 1","pages":""},"PeriodicalIF":13.6,"publicationDate":"2025-05-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144097474","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Effects of Ecological Water Replenishment on Microbial Denitrification in Aquatic Environment of Infiltration Area 生态补水对入渗区水环境微生物反硝化作用的影响

IF 13.6 1区环境科学与生态学

Journal of Hazardous Materials Pub Date : 2025-05-20 DOI: 10.1016/j.jhazmat.2025.138688

Tianyao Jiang, Tongxin Sun, Zining Guo, Ji Lu, Fei Liu, Xiangyu Guan

{"title":"Effects of Ecological Water Replenishment on Microbial Denitrification in Aquatic Environment of Infiltration Area","authors":"Tianyao Jiang, Tongxin Sun, Zining Guo, Ji Lu, Fei Liu, Xiangyu Guan","doi":"10.1016/j.jhazmat.2025.138688","DOIUrl":"https://doi.org/10.1016/j.jhazmat.2025.138688","url":null,"abstract":"Ecological water replenishment (EWR) is a crucial strategy for solving regional water shortages, yet its ecological impacts warrant further exploration. This study investigated the microbial community succession mechanism in surface water (SW) and groundwater (GW), the denitrification potential of functional bacteria, and their responses to water replenishment events of the South-to-North Water Diversion (SNWD), the largest water transfer project in China. Nitrogen and antibiotic contamination, resulting from prolonged infiltration of reclaimed water, decreased following water replenishment event. During water replenishment, both SW and GW showed an increase of microbial denitrification capacities. Post-replenishment, SW microbial denitrification capacity continued to rise, while GW returned to the baseline levels. Total organic carbon (TOC) and antibiotic resistance genes (ARGs) were the primary factors influenced denitrification before and after water replenishment. Among the denitrification steps, NO2--N reduction was most affected, linked to microbial community reassembly and resource utilization alteration after water replenishment. Furthermore, random forest analysis identified potential bacterial indicators and combinations sensitive to water replenishments highlighting key denitrification functional bacteria. These findings offer critical insights for optimizing water resource management and improving EWR effectiveness.","PeriodicalId":361,"journal":{"name":"Journal of Hazardous Materials","volume":"18 1","pages":""},"PeriodicalIF":13.6,"publicationDate":"2025-05-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144097476","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Rational design of mixed-ligand metal–organic framework with dual emission signals for real-time visual detection and efficient adsorption of glyphosate in water 合理设计具有双发射信号的混合配体金属-有机框架，实现对水中草甘膦的实时视觉检测和高效吸附

IF 13.6 1区环境科学与生态学

Journal of Hazardous Materials Pub Date : 2025-05-20 DOI: 10.1016/j.jhazmat.2025.138683

Zhenyu Lu, Xue Liu, Xiaohui Zhu, Hao Lu, Yanan Ma, Binbin Zhang, Shijun Huang, Mingdeng Xiang, Guocheng Hu, Yunjiang Yu

{"title":"Rational design of mixed-ligand metal–organic framework with dual emission signals for real-time visual detection and efficient adsorption of glyphosate in water","authors":"Zhenyu Lu, Xue Liu, Xiaohui Zhu, Hao Lu, Yanan Ma, Binbin Zhang, Shijun Huang, Mingdeng Xiang, Guocheng Hu, Yunjiang Yu","doi":"10.1016/j.jhazmat.2025.138683","DOIUrl":"https://doi.org/10.1016/j.jhazmat.2025.138683","url":null,"abstract":"Glyphosate residues have raised significant concerns owing to their detrimental effects on public health and ecosystems. The development of adsorbents capable of simultaneous visual detection and removal of glyphosate remains challenging. In this study, a fluorescent zirconium-based metal-organic framework (BDC/TCPP-MOF) with dual emission signals was synthesized through a mixed-ligand strategy. The BDC/TCPP-MOF demonstrated remarkable selectivity and sensitivity for ratiometric fluorescence detection of glyphosate, achieving a limit of detection as low as 70 nmol/L (11.8 μg/L). Notably, the BDC/TCPP-MOF-based fluorescence sensor exhibited a distinct color transition from pink to blue during glyphosate detection. Furthermore, a portable hydrogel-based detection platform integrated with smartphone was developed, enabling rapid, real-time quantitative detection of glyphosate across a wide concentration range. The BDC/TCPP-MOF also demonstrated excellent glyphosate adsorption capacity (up to 116.85 mg/g) from water. Extensive characterisations demonstrate that visual recognition and efficient adsorption are primarily attributed to glyphosate-Zr-OH interactions, hydrogen bonding, and electrostatic interactions. This study not only provides valuable insights for the design of multifunctional MOF materials but also establishes a novel dual-functional material for visual detection and adsorption of glyphosate in water, demonstrating substantial potential for environmental pollution monitoring applications.","PeriodicalId":361,"journal":{"name":"Journal of Hazardous Materials","volume":"131 1","pages":""},"PeriodicalIF":13.6,"publicationDate":"2025-05-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144097478","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Hepatotoxicity of imidacloprid in zebrafish and the alleviating role of 10-hydroxy-2-decenoi acid: insights into oxidative stress, inflammation, and gut microbiota 吡虫啉对斑马鱼的肝毒性和10-羟基-2-十二烯酸的缓解作用：对氧化应激、炎症和肠道微生物群的见解

IF 13.6 1区环境科学与生态学

Journal of Hazardous Materials Pub Date : 2025-05-20 DOI: 10.1016/j.jhazmat.2025.138695

Yujing Tang, Yandong Zhan, Shuangshuang Gao, Ting Li, Hongzhuan Xuan

{"title":"Hepatotoxicity of imidacloprid in zebrafish and the alleviating role of 10-hydroxy-2-decenoi acid: insights into oxidative stress, inflammation, and gut microbiota","authors":"Yujing Tang, Yandong Zhan, Shuangshuang Gao, Ting Li, Hongzhuan Xuan","doi":"10.1016/j.jhazmat.2025.138695","DOIUrl":"https://doi.org/10.1016/j.jhazmat.2025.138695","url":null,"abstract":"Imidacloprid (IMI), a widely used neonicotinoid pesticide, is commonly found in environmental residues and threatens organism health, especially hepatotoxicity. 10-Hydroxy-2-decenoic acid (10-HDA), a natural compound in royal jelly with recognized anti-inflammatory and antioxidant properties, has garnered interest; however, its potential in mitigating pesticide-induced hepatotoxicity remains underexplored. This study evaluated the toxic effects of IMI and the hepatoprotective role of 10-HDA in zebrafish. The results demonstrated that both acute and chronic IMI exposure (4 mg/L for 48 h in larvae; 1 mg/L for 14 d in adults) induced severe liver injury in zebrafish, manifested as elevated aminotransferase activity, histopathological alterations, enhanced hepatocyte apoptosis, dysregulated oxidative stress biomarkers, and increased reactive oxygen species (ROS) levels. Concurrently, IMI exposure activated the NF-κB signaling pathway, triggering inflammatory responses in hepatic and intestinal tissues. 16S rRNA sequencing revealed that IMI disrupted gut microbial balance, reduced diversity, and enriched pathogenic bacteria such as Plesiomonas shigelloides, suggesting a role of the gut-liver axis in hepatotoxicity. Notably, 10-HDA treatment (0.5 and 1 mM for 48 h in larvae; 1 and 10 mg/L for 14 d in adults) effectively alleviated IMI-induced damage by reducing oxidative stress, suppressing inflammation, and restoring gut microbiota homeostasis. In conclusion, the present study emphasized the hepatotoxicity of IMI and demonstrated for the first time that 10-HDA was able to counteract IMI-induced liver injury through multi-mechanism regulation such as the gut-liver axis, providing new insights into pesticide toxicity interventions based on natural compounds.","PeriodicalId":361,"journal":{"name":"Journal of Hazardous Materials","volume":"132 1","pages":""},"PeriodicalIF":13.6,"publicationDate":"2025-05-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144097482","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0