Journal of Hazardous Materials最新文献

{"title":"Spatial prediction of soil cadmium concentration: a multi-model prediction system with novel evaluation metrics","authors":"Ziqian Zhong, Qihong Zhu, Xinliang Liu, Shufang Pan, Lei Luo, Hanhua Zhu, Rui Liu, Daoyou Huang","doi":"10.1016/j.jhazmat.2025.139952","DOIUrl":"https://doi.org/10.1016/j.jhazmat.2025.139952","url":null,"abstract":"This study proposes a modular, automated Multi-Model Prediction System (MMPS) to overcome nonlinear relationships, data integration difficulties, and model instability in soil cadmium (Cd) spatial prediction under small sample conditions. We further introduce two novel evaluation metrics — Global Performance Metrics (GPM) to assess robustness across runs, and Global Mean Local Standard Deviation (GMLSD) to quantify spatial stability of prediction maps. Our system achieved high predictive accuracy, with the LGBM model demonstrating superior performance (Global R² = 0.614). Crucially, GPM yielded substantially more consistent evaluations, exhibiting up to an 88.6% reduction in performance standard deviation across random seeds compared to traditional metrics. The MMPS, which integrates geostatistical, deterministic, and machine learning algorithms, was tested in a small mining watershed in Hunan, China. Using multi-source data (remote sensing, topography, soil properties) from 149 samples, we compared 12 models. Results showed that machine learning models achieved higher prediction accuracy but tended to have lower spatial prediction stability (higher GMLSD). Topographic data was the most influential input, boosting performance by 53.5%, whereas spectral or soil data alone showed limited impact. Key driving factors were identified as distance to river, soil pH, B2 band, and organic matter. The MMPS provides a high-precision, low-cost intelligent tool for pollution management. Together with our robust evaluation framework, this research offers a new paradigm for environmental spatial prediction, enabling smarter, scalable, and more reliable pollution control strategies.","PeriodicalId":361,"journal":{"name":"Journal of Hazardous Materials","volume":"41 1","pages":""},"PeriodicalIF":13.6,"publicationDate":"2025-09-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145116700","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Phosphorus counters arsenic phytotoxicity in wheat by activating riboflavin-mediated defense response rather than reducing arsenic accumulation","authors":"Erkai He, Muhammad Adeel, Jie Ji, Hao Qiu","doi":"10.1016/j.jhazmat.2025.139950","DOIUrl":"https://doi.org/10.1016/j.jhazmat.2025.139950","url":null,"abstract":"Soil arsenic (As) contamination represents a global concern, as its accumulation leads to crop yield reduction and human health risks through food chain. Although the protective role of phosphorus (P) against As phytotoxicity has been widely documented, underlying mechanisms remained debated. This study systematically investigated the function of P in alleviating As toxicity in wheat <em>Triticum aestivum</em> L. by integrating individual uptake and growth parameters, physiological indices, visualized analysis, and metabolomic response. It was found that P supplementation (80 μm) significantly ameliorated As-induced (2.5 μm) root growth inhibition, oxidative stress, and membrane damage, with relative root elongation increased from 61.4% to 99.3% and MDA content reduced from 6.63 to 3.79 nmol/mg. Notably, under As (2.5 μm) treatment, As accumulation (0.156 to 0.149<!-- --> <!-- -->mg/g) did not differ significantly with elevated P uptake ranging from 5.32 to 7.46<!-- --> <!-- -->mg/g in wheat roots, suggesting toxic mitigation effect of P is not by suppressing As uptake. Non-targeted metabolomics revealed As exposure primarily disrupted biological pathways related to amino acids synthesis and activation, accompanied by dysregulation of the involved metabolites, such as arginine, alanine, tryptophan, threonine, and histidine, indicating that nitrogen metabolism disturbance at molecular level shaped the adverse effects at organismal level. Remarkably, these disturbances were eliminated at the highest P level, further supporting the ameliorative effect of P on As toxicity. Concurrently, P upregulated the defense-related riboflavin metabolism pathway, which are essential for multiple fundamental processes of plant. These findings demonstrated that the presence of P helped in counteracting As-induced harm not by limiting uptake but by enhancing stress defense response, thereby advancing our understanding of how P modifies As toxicity.","PeriodicalId":361,"journal":{"name":"Journal of Hazardous Materials","volume":"26 1","pages":""},"PeriodicalIF":13.6,"publicationDate":"2025-09-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145116702","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of polyethylene terephthalate microplastics on performance of sequencing-batch membrane bioreactor for simulated municipal wastewater treatment","authors":"Jianxing Wang, Jinxian Hao, Wenwen Jing, Yuxuan Gao, Shuoyu Qiu","doi":"10.1016/j.jhazmat.2025.139956","DOIUrl":"https://doi.org/10.1016/j.jhazmat.2025.139956","url":null,"abstract":"Municipal wastewater treatment plants (WWTPs) are recognized as key recipients of microplastics (MPs), with polyethylene terephthalate (PET) being among the most prevalent types in sewage. However, the systemic impact of PET MPs on integrated biological-membrane systems—especially their role in microbial ecology and membrane fouling—remains poorly understood. Therefore, the influence of PET MPs on the performance, microbial community and membrane fouling in a sequencing-batch membrane bioreactor (SMBR) was evaluated in this study. Based on the results, adding PET MPs decreased the MLSS from around 5000<!-- --> <!-- -->mg/L to 4500<!-- --> <!-- -->mg/L whereas the MLVSS/MLSS remain basically consistent. The SV₃₀ and SVI increased rapidly to 76% and 173.2<!-- --> <!-- -->mL/g on the 3^rd day (from 64% and 128.3<!-- --> <!-- -->mL/g on the 1^st day) of adding PET MPs, however, they could be restored in the following days. For pollutants removal, the COD and NH₄⁺-N removal were initially negatively affected but gradually recovered after several days of operation. The addition of PET MPs enhanced denitrification, resulting in a decrease in the effluent TN concentration from 15.1 ± 4.9<!-- --> <!-- -->mg/L to 10.4 ± 4.4<!-- --> <!-- -->mg/L. PET MPs changed microbial community structure and decreased the abundance of dominant bacteria and species diversity in activated sludge. <em>Arenimonas</em> and <em>Sphingopyxis</em> had strong relationships with PET MPs addition. PET MPs addition exacerbated membrane biofouling, and the microbial diversity on membrane at was basically consistent with activated sludge whereas the abundance changed significantly. This research provides a comprehensive understanding of how PET MPs affect the performance of integrated biological-membrane systems.","PeriodicalId":361,"journal":{"name":"Journal of Hazardous Materials","volume":"40 1","pages":""},"PeriodicalIF":13.6,"publicationDate":"2025-09-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145127366","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Composition, Distribution and Migration Processes of Cu-Cd in Various Environmental Media of the Glacial Watersheds in Tibetan Plateau","authors":"Xiaoran Wang, Zhiwen Dong, Xiaoyu Jiao, Giovanni Baccolo, Fangzhou Li","doi":"10.1016/j.jhazmat.2025.139953","DOIUrl":"https://doi.org/10.1016/j.jhazmat.2025.139953","url":null,"abstract":"The Tibetan Plateau (TP), known as the “Water Tower of Asia”, is the source of many major rivers in Asia and an important ecological security barrier in western China. It’s environmental sensitivity and unique high-altitude conditions make researching heavy metals critical. Copper (Cu) and Cadmium (Cd), as typical potentially toxic heavy elements, significantly influence biogeochemical processes in watershed ecosystems. This study systematically summarizes the composition, distribution, and enrichment characteristics of Cu and Cd in snow/cryoconite, soil, and river water within the TP. The results indicate that Cu-Cd in snow/cryoconite on TP shows moderate to heavy enrichments, which is mainly affected by local inputs and long-range pollutants via atmospheric circulation. Besides, the concentration and distribution patterns of Cu-Cd in river water of glacial watersheds varied considerably across regions, with both elements exhibiting notable enrichment. The Yarlung Zangbo River in particular, exhibited obvious impacts from anthropogenic activities. Moreover, the estimated atmospheric wet deposition fluxes of Cu and Cd in the glaciers of the TP are 127.62<!-- --> <!-- -->μg<!-- --> <!-- -->m⁻² a⁻¹ and 2.56<!-- --> <!-- -->μg<!-- --> <!-- -->m⁻² a⁻¹, respectively; while the corresponding release fluxes from glacial meltwater runoff are 10.52 ~ 3.9 × 10³ kg a⁻¹ for Cu and 0.23 ~ 12.72<!-- --> <!-- -->kg a⁻¹ for Cd. The Cu-Cd concentrations in the topsoils of the TP were unevenly distributed, with higher value in the east and lower in the west. The sources of heavy metals were complex and influenced by multiple factors, and the risk of Cd pollution in soil is widespread. Finally, we present a conceptual model illustrating the multi-source origins and migration dynamics of Cu and Cd in the glacial basins. While the TP is generally less polluted than many other global regions, Cu-Cd in glacial environments shows evident anthropogenic influence and elevated enrichment levels, potentially endangering downstream oasis ecosystems and human populations under the pressure of intensified glacier ablation.","PeriodicalId":361,"journal":{"name":"Journal of Hazardous Materials","volume":"156 1","pages":""},"PeriodicalIF":13.6,"publicationDate":"2025-09-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145116703","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Differential profiles of antibiotic resistance genes in activated sludge and biofilm in wastewater treatment plants","authors":"Haohao Sun, Weiyao Li, Shuning Zhang, Lingjue Yuan, Di Wang, Jiayue Sun, Hongyu Wang","doi":"10.1016/j.jhazmat.2025.139955","DOIUrl":"https://doi.org/10.1016/j.jhazmat.2025.139955","url":null,"abstract":"Wastewater treatment plants (WWTPs) serve as significant sources of antibiotic resistance genes (ARGs) in natural water bodies, with activated sludge and biofilm being the two most critical biological treatment processes in WWTPs. A systematic comparison of ARG composition in these two processes is essential for optimizing the design and operation of wastewater treatment systems. This study collected samples from 16 WWTPs, including one year of longitudinal monitoring data from a full-scale facility and encompassing five biofilm types. The high-throughput sequencing results revealed that the relative abundance of ARGs in activated sludge was significantly higher than in biofilms, with average relative abundances of 2075.05 ppm and 1288.78 ppm, respectively. We also identified plasmids and microbial community structure as key factors contributing to the differences in ARG composition between activated sludge and biofilm. Plasmids primarily influenced the ARGs associated with enzymatic modification mechanisms, while the microbial community structure mainly impacted the abundance of ARGs, particularly through its effect on <em>Bacteroidia</em>. This structural influence was particularly pronounced on ARGs related to enzymatic inactivation, enzymatic modification, efflux pumps, target modification, and target protection mechanisms. These findings provide valuable insights for improving the management of ARGs in WWTPs and contribute to the development of strategies for mitigating ARG proliferation in wastewater treatment systems.","PeriodicalId":361,"journal":{"name":"Journal of Hazardous Materials","volume":"11 1","pages":""},"PeriodicalIF":13.6,"publicationDate":"2025-09-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145127363","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Enhanced photo-ozonation for on-board marine oily wastewater treatment: An integrated study on efficiency and microbial trajectory","authors":"Guihua Dong, Baiyu Zhang, Renyuan Li, Yiqi Cao, Bing Chen","doi":"10.1016/j.jhazmat.2025.139949","DOIUrl":"https://doi.org/10.1016/j.jhazmat.2025.139949","url":null,"abstract":"On-board treatment of marine oily wastewater can avoid the costly transportation of large waste streams to shorelines. Employing on-board photo-ozonation, particularly ultraviolet (UV) plus ozone (O₃) (UVO₃) and persulfate (PS) enhanced UVO₃ (UVO₃PS), can realize promisingly rapid degradation of various oil components. However, direct discharge of treated effluents to marine environments would still bring unpredictable impacts on ecosystems. Herein, we integrate a photo-ozonation system with marine microcosms to clearly elucidate the treatment efficiency and microbial trajectory responding to the treated light and heavy oily wastewater over time. Results show that both processes can mineralize above 90% of crude oil within 60<!-- --> <!-- -->minutes by substantially removing n-alkanes and aromatics, and the incorporation of PS generates more powerful radicals to enhance the breakdown of products with nearly 36% lower operating cost. The microcosm results evidence that diverse hydrocarbon-degrading bacteria are enriched over time. Besides, the long-term incubation of UVO₃PS-treated oily wastewater enriches members capable of degrading labile organics, intensifies the co-occurrence of genera participating in nitrogen and sulfur metabolisms, and stimulates the microbial trajectory for natural attenuation. Due to the environmental and economic benefits provided by UVO₃PS, it is believed that this process can be selected as a promising option for on-board marine oily wastewater treatment.","PeriodicalId":361,"journal":{"name":"Journal of Hazardous Materials","volume":"15 1","pages":""},"PeriodicalIF":13.6,"publicationDate":"2025-09-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145116705","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Precise Li+ and Mg2+ Separation Enabled by Sodalite Ion Exchange Contribute to The Lithium Extraction from Low-Quality Brines","authors":"Jiayi Wang, Yichen Hao, Jinping Li, Jiangfeng Yang","doi":"10.1016/j.jhazmat.2025.139942","DOIUrl":"https://doi.org/10.1016/j.jhazmat.2025.139942","url":null,"abstract":"Adsorbents with accurate Li⁺ and Mg²⁺ separation have substantial potential for lithium extraction from low-quality brines to alleviate lithium supply shortages. Zeolites have become superior adsorbents for heavy metal adsorption in wastewater due to their unique cation exchange capacity. Herein, we utilize the difference in ion exchange kinetics between Li⁺ and Mg²⁺ to achieve efficient lithium extraction. The ion-selective adsorption behavior of sodalite (SOD), NaA and NaX zeolites is inversely proportional to their pore size (2.8, 4.1 and 7.4<!-- --> <!-- -->Å, respectively). Only small-pore SOD exhibits large Li⁺ and Mg²⁺ kinetic differences to achieve prioritized Li⁺ capture, while Mg²⁺ enters the pores more slowly, allowing the exchanged Li⁺ to be retained. Starting from the three steps of ion dehydration, ion migration and ion exchange, the exchange pathways of Li⁺ and Mg²⁺ in SOD and the energy differences required in each step are revealed. The dehydration free energy, migration energy and exchange energy barriers of Δ<em>E</em>_Li &lt; Δ<em>E</em>_Mg confirm the kinetic rate order of Li⁺ &gt; Mg²⁺, thus facilitating preferential Li⁺ capture and enabling Li⁺ and Mg²⁺ separation. This study of the regeneration cycle, batch synthesis and particle performance of SOD highlights its potential value for lithium extraction in actual brines.","PeriodicalId":361,"journal":{"name":"Journal of Hazardous Materials","volume":"54 1","pages":""},"PeriodicalIF":13.6,"publicationDate":"2025-09-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145103701","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Revealing the impact of side-chains in amino acids on the formation of haloacetamides during chlorination","authors":"Yan Shen, Xiaochen Liu, Junling Li, Jingsi Chen, Jiafu Li","doi":"10.1016/j.jhazmat.2025.139945","DOIUrl":"https://doi.org/10.1016/j.jhazmat.2025.139945","url":null,"abstract":"Haloacetamides (HAMs) is a class of highly toxic emerging nitrogenous disinfection byproducts (N-DBPs) in drinking water, however the factors influencing the formation of HAMs by amino acids remain incompletely understood. Besides, a quantitative data regarding how many HAMs in chlorinated drinking water can attribute to amino acids in source water is lacking. To address this gap, HAMs formation during chlorination for 20 amino acids with different side-chains was analyzed. HAMs yield of 20 common amino acids during chlorination was 0.04-132<!-- --> <!-- -->μg/mg-C. For different side-chains in amino acids, carboxyl group exhibited the highest HAM’s yield at 65.9<!-- --> <!-- -->μg/mg-C, followed by aromatic rings (10.2<!-- --> <!-- -->μg/mg-C), and containing nitrogen (10.1<!-- --> <!-- -->μg/mg-C), respectively. In contrast, hydroxyl groups, sulfur-containing amino acids and those with only hydrogen and alkyl groups showed the lowest HAM’s yield (&lt;1<!-- --> <!-- -->μg/mg-C). HAM yields of basic and neutral amino acids were lower than that of acidic amino acids. HAM yields of nonpolar amino acids were lower than polar amino acids. The HAM formation potentials of amino acids in source water during chlorination were 14.8-5138<!-- --> <!-- -->ng/L, with an average of 576<!-- --> <!-- -->ng/L. Aspartic acid, asparagine, and histidine accounted for as much as 97% of the theoretical HAMs formation. The theoretical calculation found that amino acids in source water contribute about 3.2% of HAMs in chlorinated drinking water, which is close to that of lab-controlled experiments (4.3%), suggesting that the role of amino acids on HAMs in chlorinated drinking water is overvalued. Our study reveals the role of precursor’s side-chains on toxic DBP formation as well their potential contribution to drinking water DBPs.","PeriodicalId":361,"journal":{"name":"Journal of Hazardous Materials","volume":"23 1","pages":""},"PeriodicalIF":13.6,"publicationDate":"2025-09-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145103753","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cotransport of zinc oxide and titanium dioxide nanoparticle aggregates with bacteria in saturated porous media: A coupled experimental and modeling approach","authors":"Rima Manik, N. Seetha, Waghela Deeksha, Eerappa Rajakumara","doi":"10.1016/j.jhazmat.2025.139941","DOIUrl":"https://doi.org/10.1016/j.jhazmat.2025.139941","url":null,"abstract":"The broad application of engineered nanoparticles in various fields leads to their inevitable release into the natural environment, causing soil and groundwater contamination. Bacteria, ubiquitous in the subsurface, can alter the transport behavior of nanoparticles. Hence, it is imperative to understand the interactions between nanoparticles and bacteria in the subsurface to protect drinking water wells from contamination. This study investigated the cotransport of metal oxide nanoparticle aggregates (zinc oxide, nZnO, and titanium dioxide, nTiO₂) with <em>E. coli</em> in saturated porous media in 1<!-- --> <!-- -->mM NaCl and pH 8 under various flow velocities (0.26 - 1.02<!-- --> <!-- -->cm/min) through column experiments and mathematical modeling. The injection concentrations of nanoparticles and <em>E. coli</em> were 15<!-- --> <!-- -->mg/L and 10⁷ CFU/mL, respectively. We observed enhanced transport of nZnO and nTiO₂ and reduced transport of <em>E. coli</em> during their cotransport compared to nanoparticle-only and <em>E. coli</em>-only transport. The contrasting transport behaviors of nanoparticles and <em>E. coli</em> are due to the formation of nanoparticle-<em>E. coli</em> heteroaggregates, which have different transport properties than free nanoparticles and <em>E. coli</em>, and the preferential attachment of nanoparticles over <em>E. coli</em> to sand surfaces. Further, nZnO transport was enhanced to a greater extent than nTiO₂ transport due to the greater rate of heteroaggregation of nZnO and <em>E. coli</em> in comparison to nTiO₂ and <em>E. coli</em>. The experimental results were successfully simulated using a model that accounted for the kinetics of heteroaggregation of nanoparticles and <em>E. coli</em>, and heteroaggregate retention in sand.<h3>Environmental Implication</h3>Engineered nanoparticles have significant health impacts on humans and ecosystems. Understanding their transport behavior in the subsurface is essential to protect wells from contamination. Bacteria are ubiquitous in soil and interact with nanoparticles. <em>E. coli</em> facilitated the transport of nanoparticles (nZnO and nTiO₂), resulting in greater groundwater contamination with nanoparticles. Moreover, bacteria lead to a greater concentration of nZnO than nTiO₂ in groundwater. However, the effect of bacteria on nanoparticle transport decreases with increasing groundwater velocity. Thus, the effect of co-contaminants, including bacteria, should be accounted for in assessing the risks of groundwater contamination caused by engineered nanoparticles.","PeriodicalId":361,"journal":{"name":"Journal of Hazardous Materials","volume":"17 1","pages":""},"PeriodicalIF":13.6,"publicationDate":"2025-09-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145116753","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Enhancing Effect of Humic Acid on Neurodevelopmental Impact of Cadmium Sulfide Nanoparticles to Zebrafish","authors":"Yizhen Xie, Xiaohong Wang, Shenqing Wang, Jiahui Wang, Li Zhou, Bing Yan","doi":"10.1016/j.jhazmat.2025.139947","DOIUrl":"https://doi.org/10.1016/j.jhazmat.2025.139947","url":null,"abstract":"Metal sulfide nanoparticles (MSNPs) are widespread in aquatic environments, where their stability and toxicity are affected by environmental factors. However, the role of dissolved organic matter (DOM) in modulating oxidative transformation and toxicity of MSNPs remains poorly understood. Here, we investigated the chemical stability and neurodevelopmental toxicity of cadmium sulfide nanoparticles (CdSNPs) in zebrafish, focusing on the effects of humic acid (HA), a representative DOM. Our results demonstrate that light promoted the generation of reactive oxygen species (ROS), thus accelerating CdSNPs dissolution and increasing cadmium uptake. However, the photoinduced release of cadmium ions was significantly decreased by HA, due to the formation of surface coating, thus inhibiting CdSNPs dissolution and decreasing cadmium uptake. Despite these opposing effects on cadmium release and uptake, light and HA did not proportionally influence the neurodevelopmental outcomes in zebrafish, as shown by behavioral response of transgenic line. The nanoparticulate form of CdSNPs and HA themselves also contributed substantially to neurotoxicity. Targeted metabolomic analyses revealed that these effects were mediated by disturbances in dopaminergic, glutamatergic, GABAergic, and glycinergic neurotransmission, with HA further enhancing the disruption of key enzymes and receptors involved in these systems. These findings provide new insights into environmental behavior and neurotoxic potential of MSNPs, informing their ecological risk assessment in natural aquatic systems.","PeriodicalId":361,"journal":{"name":"Journal of Hazardous Materials","volume":"40 1","pages":""},"PeriodicalIF":13.6,"publicationDate":"2025-09-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145116755","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}