Journal of Hazardous Materials最新文献_第9页

Comparing acute toxicity testing and extensive targeted chemical screening for risk assessment of urban stormwater pond sediments 城市雨水塘沉积物急性毒性试验与广泛靶向化学筛选风险评价的比较

IF 12.2 1区环境科学与生态学

Journal of Hazardous Materials Pub Date : 2025-05-02 DOI: 10.1016/j.jhazmat.2025.138451

Kelsey Flanagan, Godecke-Tobias Blecken, Heléne Österlund, Maria Viklander

{"title":"Comparing acute toxicity testing and extensive targeted chemical screening for risk assessment of urban stormwater pond sediments","authors":"Kelsey Flanagan, Godecke-Tobias Blecken, Heléne Österlund, Maria Viklander","doi":"10.1016/j.jhazmat.2025.138451","DOIUrl":"10.1016/j.jhazmat.2025.138451","url":null,"abstract":"<div><div>32 urban stormwater pond sediment samples were analyzed for 259 organic substances, 13 trace elements, physico-chemical parameters and acute toxicity of eluates to the bioluminescent bacteria <em>Aliivibrio fischeri</em> according to the Microtox® method. Five of these samples showed some toxicity to <em>Aliivibrio fischeri</em>. Statistical analysis was conducted to identify substances with significantly different concentrations between toxic and non-toxic samples, as well as differences in contaminant patterns between these sets. Results showed no significant differences in trace element, organic contaminant concentrations or overall contaminant patterns between toxic and non-toxic samples. However, dissolved oxygen was significantly lower in toxic than in non-toxic samples, likely due to an influence on the lability of contaminants. This work highlights the difficulty of conducting a pertinent and robust environmental hazard assessment for complex matrices composed of a large number of substances present at low concentrations and discusses the advantages and limitations of both chemical and biological approaches to environmental hazard assessment for urban stormwater sediments. Because the evaluation of urban stormwater sediments is so complex, to comprehensively and accurately analyse its risks, it is very important to consider both biological and chemical factors. Considering both will provide an accurate identification of possible risks and enhanced control of environmental risks in urban areas.</div></div>","PeriodicalId":361,"journal":{"name":"Journal of Hazardous Materials","volume":"494 ","pages":"Article 138451"},"PeriodicalIF":12.2,"publicationDate":"2025-05-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143897849","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Norgestrel shows androgenic properties and triggers reproductive neuroendocrine toxicity in the testes of Pacific oysters (Crassostrea gigas) 诺孕酮显示雄激素特性，并引发太平洋牡蛎睾丸的生殖神经内分泌毒性。

IF 12.2 1区环境科学与生态学

Journal of Hazardous Materials Pub Date : 2025-05-02 DOI: 10.1016/j.jhazmat.2025.138467

Yan Fang , Baojun Liu , Juan Wang , Haoyang Zhong , Linlin Fan , Yuchao Huang , Changkun Chen , Songtao Lu , Tao Zheng

{"title":"Norgestrel shows androgenic properties and triggers reproductive neuroendocrine toxicity in the testes of Pacific oysters (Crassostrea gigas)","authors":"Yan Fang , Baojun Liu , Juan Wang , Haoyang Zhong , Linlin Fan , Yuchao Huang , Changkun Chen , Songtao Lu , Tao Zheng","doi":"10.1016/j.jhazmat.2025.138467","DOIUrl":"10.1016/j.jhazmat.2025.138467","url":null,"abstract":"<div><div>Norgestrel (NGT), a prevalent progestin in the aquatic environment, can pose risks to vertebrates even at very low concentrations (<1 ng/L). Nevertheless, the understanding of NGT's effects on invertebrates is limited. Therefore, through histology and multi-omics, we explored the toxic effects of NGT (0, 10, and 1000 ng/L) on Pacific oysters <em>Crassostrea gigas</em> testes over 21 days. NGT accumulated in the testes and exhibited androgenic characteristics. Furthermore, transcriptomic sequencing revealed that differentially expressed genes were significantly enriched in the neurotransmitter ligand-receptor signaling pathway. A significant decrease in G protein-coupled receptors (GPCRs) and Calmodulin/ Calmodulin -dependent protein kinase gene expression was identified as the potential mechanism preventing hyperphosphorylation and G protein overactivation. Notably, the 1000 ng/L group showed clear Cytochrome P450/glutathione-s-transferase detoxification characteristics. Metabolomics analysis indicated that small peptides and organic acids were the most abundant differential metabolites, accounting for 26.96 %. The positive correlation between neuroendocrine related metabolites and several important G protein-coupled receptor genes, as revealed by correlation analysis, might play a major role in regulating NGT toxicity. In conclusion, NGT affects the reproductive neuroendocrine system in the <em>C. gigas</em> testis and triggers detoxification mechanisms. These findings provide new targets and a theoretical basis for environmental progestin toxicity and ecological risk assessment.</div></div>","PeriodicalId":361,"journal":{"name":"Journal of Hazardous Materials","volume":"494 ","pages":"Article 138467"},"PeriodicalIF":12.2,"publicationDate":"2025-05-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143898000","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Biofilm-overproducing Bacillus amyloliquefaciens strain B9ΔywcC reduces cadmium uptake in lettuce by upregulating the expression of proteins associated with root surface biofilm formation and cell membrane homeostasis 过量产生生物膜的解淀粉芽孢杆菌B9ΔywcC菌株通过上调与根表面生物膜形成和细胞膜稳态相关的蛋白质表达来减少生菜对镉的吸收

IF 12.2 1区环境科学与生态学

Journal of Hazardous Materials Pub Date : 2025-05-02 DOI: 10.1016/j.jhazmat.2025.138481

Lijing Sun , Rongrong Gao , Qian Zeng , Zhanbiao Ge , Xiafang Sheng , Linyan He

{"title":"Biofilm-overproducing Bacillus amyloliquefaciens strain B9ΔywcC reduces cadmium uptake in lettuce by upregulating the expression of proteins associated with root surface biofilm formation and cell membrane homeostasis","authors":"Lijing Sun , Rongrong Gao , Qian Zeng , Zhanbiao Ge , Xiafang Sheng , Linyan He","doi":"10.1016/j.jhazmat.2025.138481","DOIUrl":"10.1016/j.jhazmat.2025.138481","url":null,"abstract":"<div><div>In this study, <em>Bacillus amyloliquefaciens</em> strain B9 and its biofilm-overproducing B9Δ<em>ywcC</em> mutant (Δ<em>ywcC</em>M) were characterized for their effects on Cd accumulation in Italian lettuce and the underlying molecular mechanisms under hydroponic conditions. Both B9 and Δ<em>ywcC</em>M significantly reduced Cd contents in lettuce tissues compared with the controls. Furthermore, Δ<em>ywcC</em>M exhibited significantly decreased Cd accumulation and increased root surface biofilm biomass and biofilm-mediated Cd immobilization compared with B9. Proteomic analysis of lettuce root surface biofilms revealed that Δ<em>ywcC</em>M significantly upregulated the expression of several proteins compared to B9. These included IolC and IolD (associated with inositol metabolism), GlpK (associated with glycerol metabolism), TyrS (associated with tRNA synthesis and transport), and LepA and PepT (associated with protein translation and modification), which are associated with biofilm formation; ArgS and AspS (associated with tRNA synthesis and transport), LepA (associated with protein translation and modification), and GcvT (associated with aminomethyltransferase), which are involved in cell membrane homeostasis. Furthermore, Δ<em>ywcC</em>M significantly upregulated the expression of <em>iolD</em>, <em>iolI</em>, and <em>pepT</em> in the root surface biofilms relative to B9. These findings demonstrated that the biofilm-overproducing Δ<em>ywcC</em>M enhances root surface biofilm formation and stability, thereby promoting Cd immobilization and reducing Cd accumulation in lettuce leaves grown in Cd-contaminated solutions.</div></div>","PeriodicalId":361,"journal":{"name":"Journal of Hazardous Materials","volume":"494 ","pages":"Article 138481"},"PeriodicalIF":12.2,"publicationDate":"2025-05-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143897769","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Bioelectronics based on antibody-conjugated graphene field-effect transistor for response of Staphylococcal enterotoxin B as a biological weapon 基于抗体共轭石墨烯场效应晶体管响应葡萄球菌肠毒素B作为生物武器的生物电子学

IF 12.2 1区环境科学与生态学

Journal of Hazardous Materials Pub Date : 2025-05-02 DOI: 10.1016/j.jhazmat.2025.138457

Kyung Ho Kim , Eun-Ha Hwang , Ju Hong Jang , Sung Eun Seo , Jung Joo Hong , Jangwook Lee , Oh Seok Kwon

{"title":"Bioelectronics based on antibody-conjugated graphene field-effect transistor for response of Staphylococcal enterotoxin B as a biological weapon","authors":"Kyung Ho Kim , Eun-Ha Hwang , Ju Hong Jang , Sung Eun Seo , Jung Joo Hong , Jangwook Lee , Oh Seok Kwon","doi":"10.1016/j.jhazmat.2025.138457","DOIUrl":"10.1016/j.jhazmat.2025.138457","url":null,"abstract":"<div><div><em>Staphylococcal enterotoxin B</em> (SEB) is a potent toxin that is produced by <em>Staphylococcus aureus</em> and is classified as an agent for biological weapons. Various nanotechnology-based biosensors have been developed to respond to SEB-based biological weapons; however, these biosensors exhibit various limitations. A novel chimeric antibody was developed from SEB-specific hybridoma clones that were generated using native-like SEB antigen expressed via a baculovirus system. The chimeric antibody exhibited high binding specificity and subnanomolar affinity and was subsequently conjugated onto a graphene field-effect transistor-based bioelectronic (SEB bioelectronic). This device exhibited high performance with a limit of detection of 1 pg/mL and a detection range of 1 pg/mL to 100 ng/mL, demonstrating superior specific detection performance even in the presence of various interference toxin substances at 10<sup>3</sup> times higher concentrations. Moreover, the SEB bioelectronic was evaluated using nonhuman primate infection models, and the detection performance was investigated based on those for standard SEB substances. These results indicate that the SEB bioelectronic can be utilized for noncontact SEB detection in SEB-exposed onsite locations and can be applied for bioelectronic development to respond to other biological weapons through bioprobe exchanges.</div></div>","PeriodicalId":361,"journal":{"name":"Journal of Hazardous Materials","volume":"494 ","pages":"Article 138457"},"PeriodicalIF":12.2,"publicationDate":"2025-05-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143897852","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Assessing the nicotinic acetylcholine receptor-mediated enantioselective neurotoxicity of a neonicotinoid-like pollutant, chiral sulfoxaflor: Insight from the two asymmetric centers 评估烟碱乙酰胆碱受体介导的新烟碱类污染物手性亚砜的对端选择性神经毒性：来自两个不对称中心的见解

IF 12.2 1区环境科学与生态学

Journal of Hazardous Materials Pub Date : 2025-05-02 DOI: 10.1016/j.jhazmat.2025.138468

Zhi-Cong He , Tao Zhang , Xin-Fang Lu , Rui Li , Wei Peng , Qiong Mei , Qi-Zhao Wang , Fei Ding

{"title":"Assessing the nicotinic acetylcholine receptor-mediated enantioselective neurotoxicity of a neonicotinoid-like pollutant, chiral sulfoxaflor: Insight from the two asymmetric centers","authors":"Zhi-Cong He , Tao Zhang , Xin-Fang Lu , Rui Li , Wei Peng , Qiong Mei , Qi-Zhao Wang , Fei Ding","doi":"10.1016/j.jhazmat.2025.138468","DOIUrl":"10.1016/j.jhazmat.2025.138468","url":null,"abstract":"<div><div>Chiral sulfoxaflor is widely present in environmental matrices; however, the health hazards of this neonicotinoid-like pollutant remain poorly understood. This study investigated the nicotinic acetylcholine receptor (nAChR)-mediated neurotoxicity of sulfoxaflor at the enantiomeric level and elucidated the distinct roles of its two chiral centers. Results showed that the toxic response of nAChR to sulfoxaflor exhibits significant enantioselectivity and the affinity of <em>α</em><sub>7</sub> nAChR with (<em>R</em>,<em>S</em>)-/(<em>S</em>,<em>S</em>)-sulfoxaflor (－35.34/－34.84 kcal mol<sup>−1</sup>) is higher than those of their antipodes (－22.08/－22.76 kcal mol<sup>−1</sup>). The conjugations of (<em>R</em>,<em>S</em>)-/(<em>S</em>,<em>S</em>)-sulfoxaflor in agonistic mode at the orthosteric site induces crucial residues (e.g., Trp-147, Tyr-186, Leu-117) to shift toward the binding position (RMSF: 0.0968 nm to 0.3959/0.3801 nm), which disturbs the intrinsic conformational flexibility of <em>α</em><sub>7</sub> nAChR (random coil: 18.16–23.65 %/22.15 %), prompting (<em>R</em>,<em>S</em>)-/(<em>S</em>,<em>S</em>)-sulfoxaflor to exhibit enhanced activated efficacy. Furthermore, chirality at the sulfur atom plays a key role in the electrostatic contribution (Δ<em>G</em><sub>ele</sub>) to be different (－23.55/－22.3/－11.39/－12.73 kcal mol<sup>−1</sup>), rendering sulfoxaflor a higher enantioselective neurotoxicant. This study could pave away for untangling the health hazards associated with sulfoxaflor and prompt the legislature to develop environmental regulations for pollutants containing multiple chiral centers.</div></div>","PeriodicalId":361,"journal":{"name":"Journal of Hazardous Materials","volume":"494 ","pages":"Article 138468"},"PeriodicalIF":12.2,"publicationDate":"2025-05-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143897771","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Reduction recovery of Sb(III) and Sb(V) from wastewater by UV/thiourea dioxide system: Efficiency, radical generation and mechanism UV/二氧化硫脲体系还原回收废水中Sb（III）和Sb(V)：效率、自由基生成及机理

IF 12.2 1区环境科学与生态学

Journal of Hazardous Materials Pub Date : 2025-05-02 DOI: 10.1016/j.jhazmat.2025.138473

Feng Zhu , Chong Zhao , XianJia Peng , Linghao Kong , Zhenyu Xi , Chenlin Zhang , Chang Liu , Fengyu Ren , Junlong Zhao , Xinmiao Zhang

{"title":"Reduction recovery of Sb(III) and Sb(V) from wastewater by UV/thiourea dioxide system: Efficiency, radical generation and mechanism","authors":"Feng Zhu , Chong Zhao , XianJia Peng , Linghao Kong , Zhenyu Xi , Chenlin Zhang , Chang Liu , Fengyu Ren , Junlong Zhao , Xinmiao Zhang","doi":"10.1016/j.jhazmat.2025.138473","DOIUrl":"10.1016/j.jhazmat.2025.138473","url":null,"abstract":"<div><div>For antimony-containing wastewater, conventional methods, such as chemical precipitation, adsorption and membrane separation inevitably generate substantial quantities of hazardous waste. This paper introduces a UV/thiourea dioxide(TDO) reduction method, which efficiently recovers Sb(III)/Sb(V) from wastewater as the metalloid Sb(0) within 30 min, achieving a purity greater than 99.8 wt%. This work innovatively found that TDO could generate SO<sub>2</sub><sup>•-</sup> and e<sub>aq</sub><sup>-</sup> under UV light. The e<sub>aq</sub><sup>-</sup> primarily originates from the photodecomposition of TDO and SO<sub>3</sub><sup>2-</sup>, an oxidation product of SO<sub>2</sub><sup>•-</sup>. Mechanistic investigations revealed that SO<sub>2</sub><sup>•-</sup> and e<sub>aq</sub><sup>-</sup> jointly played the pivotal role in antimony reduction. The estimated contribution ratios of SO<sub>2</sub><sup>•-</sup> and e<sub>aq</sub><sup>-</sup> were approximately 2.5 % and 97.5 % for Sb(III) removal and 1.5 % and 98.5 % for Sb(V) removal. The enhancement of antimony removal as the increased pH was attributed to the accelerated cleavage of C–S bond in TDO and the enhanced photolysis of TDO. The presence of dissolved oxygen and humic acid(HA) suppressed the antimony removal due to the scavenging effect of e<sub>aq</sub><sup>-</sup> and light absorbance. This method could hierarchically recover antimony and arsenic, with antimony being removed first followed by arsenic, which has a practical prospect for antimony and arsenic-containing wastewater treatment.</div></div>","PeriodicalId":361,"journal":{"name":"Journal of Hazardous Materials","volume":"494 ","pages":"Article 138473"},"PeriodicalIF":12.2,"publicationDate":"2025-05-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143897853","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

PFHxA and PFHxS promote breast cancer progression in 3D culture: MEX3C-associated immune infiltration revealed by bioinformatics and machine learning PFHxA和PFHxS在3D培养中促进乳腺癌进展：生物信息学和机器学习揭示的mex3c相关免疫浸润

IF 12.2 1区环境科学与生态学

Journal of Hazardous Materials Pub Date : 2025-05-02 DOI: 10.1016/j.jhazmat.2025.138458

Huan Wang , Guangming Xie , Zhijin Zhang , Jing Han , Yue Zhang , Ting Xu , Daqiang Yin

{"title":"PFHxA and PFHxS promote breast cancer progression in 3D culture: MEX3C-associated immune infiltration revealed by bioinformatics and machine learning","authors":"Huan Wang , Guangming Xie , Zhijin Zhang , Jing Han , Yue Zhang , Ting Xu , Daqiang Yin","doi":"10.1016/j.jhazmat.2025.138458","DOIUrl":"10.1016/j.jhazmat.2025.138458","url":null,"abstract":"<div><div>Per- and polyfluoroalkyl substances (PFAS) are persistent environmental contaminants with widespread use and bioaccumulative potential. Short-chain PFAS such as perfluorohexanoic acid (PFHxA) and perfluorohexane sulfonate (PFHxS) have been introduced as safer alternatives to long-chain PFAS, yet their toxicological impacts remain poorly defined. In this study, we employed a 3D Gelatin methacryloyl (GelMA) hydrogel model to mimic the tumor microenvironment and investigated the effects of PFHxA and PFHxS on triple-negative breast cancer (TNBC) progression. At environmentally relevant concentrations (0.1–10 μM), both compounds significantly enhanced proliferation, migration, and invasion of MDA-MB-231 cells. Transcriptomic and machine learning analyses identified MEX3C as a key gene upregulated by PFAS exposure. Gene set enrichment analysis (GSEA) revealed activation of the PI3K-AKT-mTOR signaling pathway, which was further supported by siRNA-mediated knockdown of MEX3C, leading to a marked reduction in the expression levels of phosphorylated PI3K, AKT, and mTOR proteins. Furthermore, immune cell co-culture experiments showed that MDA-MB-231 cells with high MEX3C expression promoted M2 macrophage polarization, suppressed M1 polarization, and enhanced macrophage chemotactic activity, the immunomodulatory effects were significantly attenuated upon MEX3C knockdown. These findings establish MEX3C as a central mediator of PFAS-induced tumor progression and immune remodeling. This study provides mechanistic insight into the carcinogenic potential of emerging short-chain PFAS and underscores the need for stricter regulation to safeguard public health.</div></div>","PeriodicalId":361,"journal":{"name":"Journal of Hazardous Materials","volume":"494 ","pages":"Article 138458"},"PeriodicalIF":12.2,"publicationDate":"2025-05-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143897848","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Genome-wide identification of HIPP genes family in sorghum reveals the novel role of SbHIPP40 in accumulation of cadmium 高粱HIPP基因家族的全基因组鉴定揭示了sbhip40在镉积累中的新作用

IF 12.2 1区环境科学与生态学

Journal of Hazardous Materials Pub Date : 2025-05-02 DOI: 10.1016/j.jhazmat.2025.138478

Heng Zhang , Guowei Zhai , Xianlin Ni , Ziwen Liu , Tao Song , Yu Han , Yao Wang , Yu Shao , Fulin Wang , Guihua Zou , Xiangyang Hu , Zhengge Zhu , Ying Zhu

{"title":"Genome-wide identification of HIPP genes family in sorghum reveals the novel role of SbHIPP40 in accumulation of cadmium","authors":"Heng Zhang , Guowei Zhai , Xianlin Ni , Ziwen Liu , Tao Song , Yu Han , Yao Wang , Yu Shao , Fulin Wang , Guihua Zou , Xiangyang Hu , Zhengge Zhu , Ying Zhu","doi":"10.1016/j.jhazmat.2025.138478","DOIUrl":"10.1016/j.jhazmat.2025.138478","url":null,"abstract":"<div><div>Excessive Cadmium (Cd) content in soil poses a significant threat to plant growth and human health. Heavy metal-associated isoprenylated plant proteins (HIPPs) are pivotal regulators of metal homeostasis and detoxification. While Sorghum (<em>Sorghum bicolor</em>) is a promising phytoremediation crops, the functional roles of its HIPPs family remain poorly characterized. Here, we identified 45 <em>SbHIPP</em> genes in sorghum through genome-wide analysis. Among these, <em>SbHIPP40</em> exhibited predominantly expression in leaves and roots, with marked upregulated under Cd exposure. Subcellular localization assays revealed nuclear and plasma membrane targeting of SbHIPP40. Functional validation in yeast demonstrated <em>SbHIPP40</em> overexpression enhanced Cd tolerance in the <em>ycf1</em> mutant strain. Transgenic rice <em>SbHIPP40</em> overexpressing accumulated 1.68–3.92 fold higher Cd in stems, leaves, and grains compared to wild-type plants. Transcriptomic profiling revealed that <em>SbHIPP40</em> modulates key pathway in signal transduction and stress responses. Mutagenesis studies highlighted the indispensable role of the HMA domain in Cd binding, as its deleting drastically reduced Cd accumulation and impaired yeast growth, whereas truncation of other domain, such as isoprenylation motif, had no significant effect. Our findings establish <em>SbHIPP40</em> as a pivotal Cd accumulator via its HMA domain, advancing understanding of sorghum’s Cd detoxification mechanisms and offering a genetic resource for enhancing phytoremediation strategies.</div></div>","PeriodicalId":361,"journal":{"name":"Journal of Hazardous Materials","volume":"494 ","pages":"Article 138478"},"PeriodicalIF":12.2,"publicationDate":"2025-05-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143901274","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Pesticide exposure induces risks of gestational anemia by maternal gut microbiota: A prospective cohort study 农药暴露通过母体肠道菌群诱发妊娠贫血风险：一项前瞻性队列研究

IF 12.2 1区环境科学与生态学

Journal of Hazardous Materials Pub Date : 2025-05-02 DOI: 10.1016/j.jhazmat.2025.138465

Chao Dong , Shumin Yu , Siting Deng , Ziye Xia , Flores Carpintero Rigoberto , Mazhar Sultan , Xiaoyu Xu , Bowen Jin , Quanquan Guan , Zhibin Sun , Yankai Xia

{"title":"Pesticide exposure induces risks of gestational anemia by maternal gut microbiota: A prospective cohort study","authors":"Chao Dong , Shumin Yu , Siting Deng , Ziye Xia , Flores Carpintero Rigoberto , Mazhar Sultan , Xiaoyu Xu , Bowen Jin , Quanquan Guan , Zhibin Sun , Yankai Xia","doi":"10.1016/j.jhazmat.2025.138465","DOIUrl":"10.1016/j.jhazmat.2025.138465","url":null,"abstract":"<div><div>Gut microbiota regulates host hematopoiesis, with notable alterations observed in individuals with gestational anemia (GA). Pregnancy-induced susceptibility to environmental stressors, including widespread pesticide residuals, may disrupt gut microbiota, further contributing to the development of GA. This study sought to investigate population-level associations between pesticide exposure and GA, with a focus on the mediating role of gut microbiota. Pregnant women were prospectively recruited with blood and stool samples collected in the second trimester. Red blood cell (RBC) count and hemoglobin (Hb) were assessed in the second and third trimesters. GA was diagnosed in 22.7 % of participants during the second trimester and 29.8 % during the third trimester. Robust associations were found between serum pesticides, such as atrazine and clomazone, and an increased risk of GA and reduced Hb and RBC count, both at a single time point and longitudinally. Pesticide exposure was linked to altered microbial Shannon index, with 24 significant associations identified between pesticides and individual taxa, nearly half of which involved <em>Roseburia</em>. Furthermore, both Shannon index and the Firmicutes/Bacteroidetes (F/B) ratio were negatively associated with RBC count. A total of 20 taxa showed associations with GA and hematological parameters. Finally, mediation analysis demonstrated that Shannon index and <em>Roseburia</em> mediated the relationships of pesticide exposure with RBC count and GA, respectively. These findings not only highlight the anemia-inducing effects of pesticides, but also inform microbiota-based interventions for managing GA and maternal health.</div></div>","PeriodicalId":361,"journal":{"name":"Journal of Hazardous Materials","volume":"494 ","pages":"Article 138465"},"PeriodicalIF":12.2,"publicationDate":"2025-05-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143901275","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Incidence of respiratory diseases associated with per- and polyfluoroalkyl substances (PFAS) in PM2.5: New evidence from a population-based survey of Pearl River Delta (PRD), China 与PM2.5中全氟和多氟烷基物质（PFAS）相关的呼吸系统疾病发病率：来自中国珠江三角洲（PRD）人群调查的新证据

IF 12.2 1区环境科学与生态学

Journal of Hazardous Materials Pub Date : 2025-05-02 DOI: 10.1016/j.jhazmat.2025.138485

Lu-Yin Wu , Wan-Ting He , Mohammed Zeeshan , Yang Zhou , Yun-Ting Zhang , Li-Xia Liang , Jing-Wen Huang , Jia-Xin Zhou , Kun Zhao , Wen-Wen Bao , Li-Zi Lin , Zhao-Huan Gui , Ru-Qing Liu , Li-Wen Hu , Zhi Wang , Guang-Hui Dong

{"title":"Incidence of respiratory diseases associated with per- and polyfluoroalkyl substances (PFAS) in PM2.5: New evidence from a population-based survey of Pearl River Delta (PRD), China","authors":"Lu-Yin Wu , Wan-Ting He , Mohammed Zeeshan , Yang Zhou , Yun-Ting Zhang , Li-Xia Liang , Jing-Wen Huang , Jia-Xin Zhou , Kun Zhao , Wen-Wen Bao , Li-Zi Lin , Zhao-Huan Gui , Ru-Qing Liu , Li-Wen Hu , Zhi Wang , Guang-Hui Dong","doi":"10.1016/j.jhazmat.2025.138485","DOIUrl":"10.1016/j.jhazmat.2025.138485","url":null,"abstract":"<div><div>Epidemiological studies have evinced that particulate matter (PM) is linked to respiratory diseases, but the relationship between the specific constituents of PM and respiratory diseases remains scarce. Here, we evaluated the relationship between PFAS in PM<sub>2.5</sub> with respiratory diseases. In this study, from May 2016 to May 2018, we recruited 131,346 school-aged children and adolescents living in Pearl River Delta, Guangdong Province, China. Participants self-reported the respiratory diseases, including asthma, wheezing, phlegm, cough and rhinitis. Logistic regression and qg-comp models were used to analyze the relationship between PFAS exposure and respiratory diseases. We found several PFAS were significantly associated with higher prevalence of respiratory diseases. For instance, higher quintiles of PFSA exposure (Q2-Q4), as compared to Q1, were associated with greater odds of respiratory diseases: 1.35 (95 %CI: 1.23, 1.48) in Q2, 1.95 (95 %CI: 1.78, 2.14) in Q3 and 2.83 (95 %CI: 2.76, 3.11) in Q4. Furthermore, qg-comp model analysis revealed PFCA as the most important weight in respiratory diseases. Moreover, the effect estimates were higher in boys, older children (>12 years old) and overweight/obesity, indicating the vulnerability of these subpopulations. In summary, exposure to PFAS, a specific PM<sub>2.5</sub> constituent, potentially increases the risk of respiratory diseases among school-aged children and adolescents.</div></div>","PeriodicalId":361,"journal":{"name":"Journal of Hazardous Materials","volume":"494 ","pages":"Article 138485"},"PeriodicalIF":12.2,"publicationDate":"2025-05-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143897851","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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