Journal of Hazardous Materials最新文献

{"title":"Health Impacts of Asphalt Emissions: Examining Neurological Risks and the Need for Long-Term Exposure Mitigation","authors":"Elham H. Fini, Farideh Pahlavan, Natalie Ortiz Vega, Adriana Bibo, Harpreet Kaur, Hamid Ghasemi, Sand Aldagari, Albert Hung, Latha Kannan, Hessam Yazdani, R. Grace Zhai, Nichole Link, Laura K.G. Ackerman-Biegasiewicz, Judith Klein-Seetharaman","doi":"10.1016/j.jhazmat.2024.136849","DOIUrl":"https://doi.org/10.1016/j.jhazmat.2024.136849","url":null,"abstract":"Asphalt, widely used in infrastructure, emits complex chemical mixtures throughout its service life, posing significant risks to human health and the environment. This expanded understanding extends the concern from a construction-related hazard to a broader public health issue, especially affecting vulnerable populations like children who play on blacktop surfaces. Despite increased awareness, the specific mechanisms behind asphalt emissions, their impact on asphalt deterioration, and their effects on the human nervous system remain poorly understood. Our study addresses these knowledge gaps by examining the long-term health effects of asphalt emissions, focusing on neurological impacts. We investigate how environmental stressors and asphalt’s chemical composition influence emission types and severity, using a combination of in vitro experiments, Drosophila melanogaster models, and advanced computational analyses. FTIR analysis reveals that as asphalt ages, emissions evolve from aliphatic to aromatic compounds, increasing toxicity. Our results demonstrate significant neurological damage from asphalt emissions, with effects worsening with age and being more pronounced in females, as shown in the Drosophila model, emphasizing the need for gender-specific health risk research. In vitro studies using 3T3L1 cells show that VOC exposure disrupts lipid droplet formation and metabolism, processes linked to neurodegenerative disorders. To mitigate emissions, our novel approach introduces wood-based biochar as a functional carbon to enhance intermolecular interactions within asphalt. GC-MS analysis indicates that biochar reduces VOC emissions by up to 76%, while molecular dynamics (MD) simulations highlight biochar's effectiveness in hindering free-radical diffusion. Density functional theory (DFT) calculations confirm biochar's role, with adsorption energies of -20.4<!-- --> <!-- -->kcal/mol, demonstrating strong and stable interactions that decelerate oxidative aging and mass loss. These findings offer a comprehensive understanding of emission mechanisms and propose a sustainable strategy to enhance asphalt durability while reducing environmental and health risks. This in turn provides evidence-based recommendations for the asphalt industry, emphasizing proactive measures toward long-term exposure mitigation.<h3>Synopsis</h3>Asphalt emits chemicals throughout its service life, posing neurological risks, especially to vulnerable groups, and needs emission mitigation.","PeriodicalId":361,"journal":{"name":"Journal of Hazardous Materials","volume":"142 1","pages":""},"PeriodicalIF":13.6,"publicationDate":"2024-12-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142820965","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Distinct baseline toxicity of volatile organic compounds (VOCs) in gaseous and liquid phases: mixture effects and potential molecular mechanisms","authors":"Shuo Yang, Zhiwei Shao, Ling N. Jin, Liuwen Chen, Xiang Zhang, Mingliang Fang, , Jianmin Chen","doi":"10.1016/j.jhazmat.2024.136890","DOIUrl":"https://doi.org/10.1016/j.jhazmat.2024.136890","url":null,"abstract":"Volatile organic compounds (VOCs) are significant pollutants found in various environments, posing health risks. Traditionally, the gaseous VOCs are adsorbed and eluted in liquid phases, and then subjected to toxicity testing, which deviates from the actual exposure scenarios of gaseous VOCs. How the physical states of VOCs (gaseous or liquid) affect their toxicity has not been well understood. This study examined the baseline toxicity of VOCs in both gaseous and liquid phases using a self-assembled passive colonization hydrogel (SAPCH) with luminous bacteria (<em>Vibrio fischeri</em>). The findings revealed that gaseous VOCs exhibited higher baseline toxicity than their liquid counterparts, attributed to the higher free energy and electronic activity of gaseous VOC molecules. Furthermore, the study elucidated that the differences in electronic transitions and energy gaps significantly impact the combined toxicity of VOC mixtures in different phases. Understanding these differences is crucial for assessing the real-world impact of VOCs on health and the environment.","PeriodicalId":361,"journal":{"name":"Journal of Hazardous Materials","volume":"248 1","pages":""},"PeriodicalIF":13.6,"publicationDate":"2024-12-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142820945","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Potential ecological risk of microplastics contamination to environment in protect area lakes","authors":"Li Naying, Mei Xintong, Zhong Bo, Wang Xiaofeng, Liu Xin, Yang zao, Lin Honghui, He Yixin","doi":"10.1016/j.jhazmat.2024.136863","DOIUrl":"https://doi.org/10.1016/j.jhazmat.2024.136863","url":null,"abstract":"Microplastics (MPs) in freshwater have been extensively studied on a global scale. However, a deeper understanding is still required regarding the occurrence characteristics and ecological risks of MPs in protected area lakes(PAL). Here, the study investigated MPs pollution in PAL, outside protected areas lakes (OPAL), and ponds (OPAP) in the eastern Qinghai-Tibetan Plateau, and a comprehensive analysis was conducted comparing lakes or ponds from different income regions. The results showed that PAL has a single source of contamination, while OPAL and OPAP exhibited more diverse MP sources. The surface of all samples showed significant physicochemical changes like oxygen-containing functional groups and potential signs of biodegradation. Microbiome analysis identified potential plastic-degrading bacteria on MPs, which varied by polymer type. Ecological risk assessment revealed that OPAL and OPAP face higher ecological risks, particularly from polymers like PVC and PC, while PAL has low risk. However, we should also consider the environmental changes over the past 100 years of history in this region and emphasize the environmental health of PAL. Notably, MPs pollution is more severe in lower-middle-income regions, highlighting the urgent need for stricter controls.","PeriodicalId":361,"journal":{"name":"Journal of Hazardous Materials","volume":"14 1","pages":""},"PeriodicalIF":13.6,"publicationDate":"2024-12-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142820971","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Selective cesium extraction from highly saline solution using hybrid capacitive deionization with zinc-doped manganese hexacyanoferrate electrode","authors":"Mengdie Pang, Jianguo Zhou, Hengjian Mao, Yingsheng Xu, Hongjian Zhou","doi":"10.1016/j.jhazmat.2024.136889","DOIUrl":"https://doi.org/10.1016/j.jhazmat.2024.136889","url":null,"abstract":"Recently, hybrid capacitive deionization (HCDI) has garnered significant attention for its potential in the selective extraction of cesium (Cs) from radioactive wastewater and salt lakes, which is crucial for resolving the supply-demand imbalance of cesium resources and eliminating radioactive contamination. However, developing HCDI electrodes capable of effectively separating and extracting Cs remains a significant challenge. In this work, we proposed an innovative strategy involving the doping of inactive metal ions to develop zinc-doped manganese hexacyanoferrate (ZMFC) as an HCDI cathode. This approach leveraged the synergistic effects of ion sieving of three-dimensional lattice and zinc doping to regulate electrochemical activity, enabling the selective electrochemical extraction of Cs⁺ ions from highly saline solutions. The optimized ZMFC-0.1 electrodes exhibited a maximum electrosorption capacity of 299.9<!-- --> <!-- -->mg<!-- --> <!-- -->g^–1 in a 400<!-- --> <!-- -->mg<!-- --> <!-- -->L^–1 Cs⁺ ion solution and maintained a high-capacity retention rate of 80.1% after 50 consecutive absorption-desorption cycles in a 200<!-- --> <!-- -->mg<!-- --> <!-- -->L^–1 Cs⁺ ion solution. Moreover, ZMFC-0.1 showed a high selectivity coefficient of 27.4 at a Cs⁺/Na⁺ molar ratio of 1:40. Density functional theory (DFT) simulation revealed that manganese hexacyanoferrate (MnHCF) retains high stability and electrochemical activity following zinc atom doping. In-situ X-ray diffraction and theoretical calculations provided deeper insights into the mechanisms underlying reversible capacitive adsorption and selective Cs⁺ ion separation. The effectiveness of cesium selective extraction from brine in Xizang suggests that the ZMFC-0.1 electrodes hold significant promise for cesium recovery from salt lakes. This work presents a promising strategy for the electrochemical extraction of cesium from radioactive wastewater and salt lakes.","PeriodicalId":361,"journal":{"name":"Journal of Hazardous Materials","volume":"29 1","pages":""},"PeriodicalIF":13.6,"publicationDate":"2024-12-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142820961","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pyraclostrobin repeated treatment altered the degradation behavior in soil and negatively affected soil bacterial communities and functions","authors":"Lingxi Han, Yiran Wang, Yajie Wang, Han Xu, Mingyu Liu, Jiyun Nie, Bin Huang, Qianwen Wang","doi":"10.1016/j.jhazmat.2024.136876","DOIUrl":"https://doi.org/10.1016/j.jhazmat.2024.136876","url":null,"abstract":"This study investigated the degradation dynamics of the fungicide pyraclostrobin in three apple orchard soils, along with the responses of soil bacterial community compositions, functions, co-occurrence patterns, and soil nitrogen cycling, under repeated treatment strategies in laboratory conditions. The degradation half-lives of pyraclostrobin varied across the soil types, ranging from 15.7 to 43.4 days, in the following order: Anyang soil &gt; Qingdao soil &gt; Yangling soil. Repeated pyraclostrobin treatment affected degradation behaviors across the different soils. Pyraclostrobin significantly inhibited soil microbial activity and reduced soil bacterial diversity, with more pronounced negative effects observed at high-concentration treatment. Pyraclostrobin clearly changed soil bacterial community structures, significantly enriching potentially degradative bacterial genera such as <em>Methylibium</em> and <em>Nocardioides</em>, which showed increases in the relative abundances of 3.0%–181.8% compared with control. Additionally, pyraclostrobin reduced the complexity of soil bacterial networks and modified the diversity of functional modules. Notably, repeated treatment severely disrupted soil nitrogen cycling, with the absolute abundances of <em>amoA</em>, <em>amoB</em>, <em>nifH</em>, <em>nirK</em>, and <em>nirS</em> in high-concentration treatment decreasing by up to 19.4%–91.8% compared with control. Collectively, pyraclostrobin repeated application altered the degradation behavior, inhibited soil microbial activities, modified soil bacterial community structures and co-occurrence patterns, and seriously disrupted soil nitrogen cycling.<h3>Environmental Implication</h3>Substantial and frequent application of a fungicide pyraclostrobin in apple production has caused serious soil pollution. However, the degradation characteristics of pyraclostrobin in different soil types and the ecological effects after repeated application remains unknown.Here, the degradation dynamics of pyraclostrobin in three apple orchard soils and the responses of the soil bacterial community compositions, functions, co-occurrence patterns, and soil nitrogen cycling were investigated under repeated treatment strategies. The results can provide guidance for pyraclostrobin rational and safe application in apple production and provide basic data for soil ecological risk assessments and pollution control in long-term pyraclostrobin-contaminated apple orchard soils.","PeriodicalId":361,"journal":{"name":"Journal of Hazardous Materials","volume":"51 1","pages":""},"PeriodicalIF":13.6,"publicationDate":"2024-12-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142820962","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Switchable surface FeII/III sites for water/sediment remediation through enhanced selective oxidation and ROS regulation: Performance, mechanism and application","authors":"Yi Ren, Jun Li, Chao Liu, Weiming Zhang, Bo Lai","doi":"10.1016/j.jhazmat.2024.136799","DOIUrl":"https://doi.org/10.1016/j.jhazmat.2024.136799","url":null,"abstract":"Selective oxidation relying on high-valent iron-oxo species (Fe(IV/V)) is a promising way of effective organic decontamination. However, Fe(IV/V) formation and further purposeful reinforcement production are commonly insufficient and unsustainable. Herein, cerium (Ce) modification strategy was adopted for efficient micropollutants removal through boosting Fe(IV/V) generation. Kinetic rate of sulfamethoxazole (SMX) removal through peracetic acid (PAA) activation by FeCe-O-CN is 4.1-fold of that without Ce doping. Ce modification lowered energy barrier of the key reaction pathway (*OH→*O) during Fe(IV/V) formation and accelerated the exposure of the surface Fe^II site for Fe(IV) production. Steady-state concentration of Fe(IV) and Fe(V) in FeCe-O-CN/PAA process is 2.5 × 10⁻⁸ and 9.7 × 10⁻¹¹ M with its corresponding contribution to SMX removal as 64 % and 36 %. Not only intensified SMX removal, Ce modification significantly reduced the toxicity of transformation products. Furthermore, FeCe-O-CN/PAA system satisfies favorable decontaminant in long-term runs, anti-interference, and significantly alleviated bioaccumulation in plants. This study provides a new insight into the association between Ce modification and Fe(IV/V) generation in PAA activation and offered a feasible way for enhanced selective oxidation.","PeriodicalId":361,"journal":{"name":"Journal of Hazardous Materials","volume":"16 1","pages":""},"PeriodicalIF":13.6,"publicationDate":"2024-12-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142820972","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ensemble learning-assisted quantitative identifying influencing factors of cadmium and arsenic concentration in rice grain based multiplexed data","authors":"Yakun Wang, Zhuo Zhang, Cheng Cheng, Chouyuan Liang, Hejing Wang, Mengsi He, Haochong Huang, Kai Wang","doi":"10.1016/j.jhazmat.2024.136869","DOIUrl":"https://doi.org/10.1016/j.jhazmat.2024.136869","url":null,"abstract":"Rapid and accurate prediction of rice Cd (rCd) and rice As (rAs) bioaccumulation are important for assessing the safe utilization of rice. Currently, there is lack of comprehensive and systematic exploration of the factors of rCd and rAs. Herein, ensemble learning (EL) was first used to analysis the 23 factors in 8 categories (heavy metal pollution characteristics, soil properties, geographical characteristics, meteorological factors, socio-economic factors, environmental factors, rice type, and nutrient element) in typical regions of China based on the results of 193 research papers from 2000 to 2024 in Web of Science database. Three machine learning methods were used to predict rCd and rAs concentrations and identify the key factors in each region, and explored the mechanism of Cd and As uptake in rice. The results showed that there were large differences in the factors affecting rice enrichment for the same heavy metal in different regions. For Cd, rice type (48.30 %), soil characteristics (28.14 %), and environmental factors (61.30 %) were the most important factors in Central South, East China, and Southwest China, respectively. For As, soil properties (34.01 %) and geographical characteristics (50.22 %) had the greatest influence in Central South and East China, respectively. Our study provided valuable insights into the prediction of rCd and rAs, thus contributing to ensuring food safety and preventing Cd and As exposure-associated health risks.","PeriodicalId":361,"journal":{"name":"Journal of Hazardous Materials","volume":"29 1","pages":""},"PeriodicalIF":13.6,"publicationDate":"2024-12-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142820969","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mechanistic insights into the viral microorganism inactivation during lime stabilization for wastewater sludges","authors":"Weijun Zhang, Yuxi Zong, Jianbo Zhang, Jing Ai, Hang He, Lanfeng Li, Sainan Peng, Hao Zhou, Dongsheng Wang, Qilin Wang","doi":"10.1016/j.jhazmat.2024.136884","DOIUrl":"https://doi.org/10.1016/j.jhazmat.2024.136884","url":null,"abstract":"The pathogens inactivation in wastewater sludges is vitally important for safely managing solid wastes and protecting public and environmental health especially in the emergency. Reports have shown the effectiveness of lime to kill virus pathogens in sludges, but mechanism of virus inactivation and related human diseases is unclear. This study evaluated representative limes of CaO/CaO₂ on actual viral microorganism inactivation by viral metagenomic sequencing technology. As results, the CaO₂ treatment enhanced the sludge hydrolysis and enveloped viral pathogens suppression via EPS structure destruction by oxidative radical generations; while CaO suppressed most of none-enveloped plant related viral pathogens. Most of the viromes of plant virus including <em>Virgaviridae</em> and <em>Nodaviridae</em> were inactivated by CaO, but the human virus-<em>Feirsviridae</em> and plant virus-<em>Solemoviridae</em> were occurred after lime stabilization compared to untreated sludge, with abundances of 1%-37% and 21%-32% in CaO-treated (CaO-T) and CaO₂-treated (CaO₂-T) samples, respectively. In addition, metatranscriptome analysis revealed distinct gene expression patterns between the CaO-T and CaO₂-T sludges, in which <em>lipopolysaccharide biosynthesis</em> (LPS) and <em>aminoacyl-tRNA synthetases</em> (ARSs) in CaO-T, the formation of <em>ribosome</em> in CaO₂-T were crucial to RNA virus regrowth in sludge. These findings suggested neither of CaO and CaO₂ could completely suppress pathogens in sludge, and the effect of representative limes of CaO and CaO₂ on the viral pathogen diversity, abundance, and metabolic function of the core microbiome on virus suppression and regrowth were ignored. Therefore, combined processes were recommended to provide possible alternatives for sludge safe management in pandemic emergencies.","PeriodicalId":361,"journal":{"name":"Journal of Hazardous Materials","volume":"47 1","pages":""},"PeriodicalIF":13.6,"publicationDate":"2024-12-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142820966","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Co-resistance is the dominant mechanism of co-selection and dissemination of antibiotic resistome in nano zinc oxide polluted soil","authors":"R. Dinesh, CP Sreena, TE Sheeja, V Srinivasan, KP Subila, Charles Sona, IP Vijesh Kumar, M Anusree, M Alagupalamuthirsolai, K Jayarajan, V Sajith","doi":"10.1016/j.jhazmat.2024.136885","DOIUrl":"https://doi.org/10.1016/j.jhazmat.2024.136885","url":null,"abstract":"The broader soil bacterial community responses at eco-toxicologically relevant levels of nano ZnO (nZnO) focussing on co-selection of antibiotic resistance (AR) was investigated. nZnO imposed a stronger influence than the bulk counterpart (bZnO) on antibiotic resistance genes (ARGs) with multidrug resistance (MDR) systems being predominant (63% of total ARGs). Proliferation of biomarker ARGs especially for last resort antibiotic like vancomycin was observed and <em>Streptomyces</em> hosted multiple ARGs. nZnO was the major driver of resistome with efflux systems dominating the AR mechanism. Environmental risk associated with nZnO was mediated through metal driven co-selection of ARGs and their probable transfer to eukaryotic hosts through horizontal gene transfer (HGT) <em>via</em> mobile genetic elements (MGEs). Novel resistance genes <em>tetA, mdtA, int</em> and <em>tnpA</em> validated in our study can be used as biomarkers for rapid detection of nZnO toxicity in agricultural soils. qRT-PCR validation of resistome in the rhizosphere soil microbiome of turmeric indicated that Zn levels in rhizosphere soil decreased by 16% compared to bulk soil with 80% bioaccumulation in rhizomes at 1000<!-- --> <!-- -->mg Zn kg^-1 and subsequent down regulation of ARGs. Expression of key biosynthetic genes for curcumin in turmeric rhizomes showed an increase up to 500<!-- --> <!-- -->mg Zn kg^-1 as nZnO. Validation of co-selection phenomenon in microcosm with 10<!-- --> <!-- -->mg<!-- --> <!-- -->kg^-1 tetracycline without added Zn indicated 20% upregulation of Zn resistance genes (ZRGs) like <em>czcA, yiip</em> and <em>zntA</em>.","PeriodicalId":361,"journal":{"name":"Journal of Hazardous Materials","volume":"35 1","pages":""},"PeriodicalIF":13.6,"publicationDate":"2024-12-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142820963","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pd/Cu-TCPP(Fe)-Polydopamine Mediated Magnetic Relaxation Switching Immunosensor for Sensitive Detection of Chlorpyrifos","authors":"Yongzhen Dong, Jiawei Liu, Liqin Kong, Dongyang Deng, Long Wu, Yiping Chen","doi":"10.1016/j.jhazmat.2024.136882","DOIUrl":"https://doi.org/10.1016/j.jhazmat.2024.136882","url":null,"abstract":"This study presents the development of a magnetic relaxation switching (MRS) immunosensor for the sensitive detection of chlorpyrifos (CPF) with a signal amplification strategy using Pd/Cu-TCPP(Fe) hybrid nanosheets and polydopamine (PDA). Pd/Cu-TCPP(Fe) nanosheets, which exhibit high peroxidase-like activity and excellent storage stability, making them suitable replacements for natural enzymes in biosensors, are further functionalized with goat anti-mouse IgG (Ab₂) to construct an immunosensor. The mechanism relies on the competition between free CPF and the immobilized bovine serum albumin-CPF conjugates for antibody binding, which modulates the aggregation of magnetic nanoparticles (MNPs) that are related to the transverse relaxation time. The optimized immunosensor shows a linear detection range from 0.5<!-- --> <!-- -->ng/mL to 100<!-- --> <!-- -->ng/mL and a limit of detection (LOD) of 0.24<!-- --> <!-- -->ng/mL, outperforming traditional enzyme-linked immunosorbent assay (ELISA) methods by achieving an LOD that is about 9 times lower. Real sample analysis demonstrates the applicability of the Pd/Cu-TCPP(Fe)-PDA-MRS immunosensor for detecting CPF residues in tomato and water samples, with results well consistent with those obtained using gas chromatography. This work highlights the potential of nanomaterials in enhancing the performance of MRS immunosensors for pesticide residue analysis in environmental and food safety monitoring.","PeriodicalId":361,"journal":{"name":"Journal of Hazardous Materials","volume":"17 1","pages":""},"PeriodicalIF":13.6,"publicationDate":"2024-12-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142820964","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}