Journal of Hazardous Materials最新文献

{"title":"Integration of comparative cytology, ionome, transcriptome and metabolome provide a basic framework for the response of foxtail millet to Cd stress","authors":"Jie Zheng, Xinyue Wang, Rong Huang, Peiyu Xian, Jian Cui, Aduragbemi Amo, Liang Chen, Yuanhuai Han, Siyu Hou, Yang Yang","doi":"10.1016/j.jhazmat.2025.137684","DOIUrl":"https://doi.org/10.1016/j.jhazmat.2025.137684","url":null,"abstract":"Apart from directly affecting the growth and development of crops, Cd in the soil can easily enter the human body through the food chain and pose a threat to human health. Therefore, understanding the toxicity of Cd to specific crops and the molecular mechanisms of their response to Cd is essential. In this study, hydroponic experiments were utilized to study the response of foxtail millet to Cd stress through phenotypic investigation, enzyme activity determination, ultrastructure, ionome, transcriptome and metabolome. With the increase in cadmium concentration, both the growth and photosynthetic capacity of foxtail millet seedlings are severely inhibited. The ultrastructure of cells is damaged, cells are deformed, chloroplasts swell and disappear, and cell walls thicken. Cd stress affects the absorption, transport, and redistribution of beneficial metal ions in the seedlings. Multi-omics analysis reveals the crucial roles of glycolysis, glutathione metabolism and phenylpropanoid and lignin biosynthesis pathways in Cd detoxification via energy metabolism, the antioxidant system and cell wall changes. Finally, a schematic diagram of foxtail millet in response to Cd stress was we preliminarily drew. This work provides a basic framework for further revealing the molecular mechanism of Cd tolerance in foxtail millet.","PeriodicalId":361,"journal":{"name":"Journal of Hazardous Materials","volume":"65 1","pages":""},"PeriodicalIF":13.6,"publicationDate":"2025-02-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143463136","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Characterization of per- and polyfluoroalkyl substances (PFASs) in Chinese river and lake sediments","authors":"Roberto Xavier Supe Tulcan, Christian Miguel Huarez Yarleque, Xiaoxia Lu, Gulijiazi Yeerkenbieke, Valeria Ochoa Herrera, Viraj Gunarathne, Gabriela Salome Yánez-Jácome","doi":"10.1016/j.jhazmat.2025.137680","DOIUrl":"https://doi.org/10.1016/j.jhazmat.2025.137680","url":null,"abstract":"Sediment pollution by per- and polyfluoroalkyl substances (PFASs) is an emerging environmental concern with far-reaching implications, attracting considerable public, scientific and regulatory attention. This study analyzed 72 articles published since 2010 to assess the accumulation, sources, spatiotemporal trends, and contributing factors of PFAS pollution in surface sediments across China. The total concentrations of PFASs at the reviewed sites ranged from 0.001 to 10700<!-- --> <!-- -->ng/g, with the maximum concentration detected in the Xiaoqing River, Shandong province. Excluding the Xiaoqing River, the mean total PFAS concentrations at other sites were below 200<!-- --> <!-- -->ng/g. Although long-chain PFASs have been frequently associated with sediment phases due to their hydrophobicity, short-chain legacy and emerging PFASs also exhibited high concentrations, often being the dominant analytes at several sites because of their significant partition coefficients in sediments of China. Fluorochemical industries were identified as the most significant contributors to sediment PFAS accumulation, with concentrations up to ten times higher than those in areas affected by other sources. Risk assessments revealed differing outcomes based on chronic and acute toxicological data. Acute data indicated high ecological risks to aquatic organisms—including daphnids, green algae, mysids, and fish—from long-chain PFCAs and PFOS exposure at up to 19 sites. In contrast, chronic data derived from SSD for PFOS and PFOA, considering the maximum concentrations found across sites, suggested high chronic risks at only 1 and 4 sites, respectively. These findings, combined with the widespread occurrence of fluorochemical industries and the adsorption and bioaccumulative behavior of legacy and emerging PFASs in sediments, underscore the need for expanded assessments in underrepresented regions of China to comprehensively evaluate ecological and human health risks.","PeriodicalId":361,"journal":{"name":"Journal of Hazardous Materials","volume":"2 1","pages":""},"PeriodicalIF":13.6,"publicationDate":"2025-02-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143451698","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The impact of microplastics on antibiotic resistance genes, metal resistance genes, and bacterial community in aquaculture environment","authors":"Haochang Su, Wujie Xu, Xiaojuan Hu, Yu Xu, Guoliang Wen, Yucheng Cao","doi":"10.1016/j.jhazmat.2025.137704","DOIUrl":"https://doi.org/10.1016/j.jhazmat.2025.137704","url":null,"abstract":"Microplastics are emerging contaminants. However, their effects on antibiotic resistance genes (ARGs), metal resistance genes (MRGs), and the structure and abundance of bacterial communities, particularly pathogens, in aquaculture environments remains poorly understood. Therefore, this study investigated the effect of microplastics of different sizes on the abundance and distribution of ARGs, MRGs, and bacterial communities in aquaculture environments. The results revealed that, compared with pond water, large microplastics harbored significantly higher ARG abundances, particularly for multidrug-resistant genes; notably, level-I- and -II-risk ARGs were more prevalent on microplastics, highlighting the potential for horizontal gene transfer. Microplastics also exhibited a propensity to aggregate pathogenic bacteria such as <em>Brucella</em> and <em>Pseudomonas</em>, which could pose direct risks to aquatic product safety and public health. Network and differential network analyses revealed significant correlations between bacterial genera and ARG/MRG abundance, particularly on microplastics. Therefore, our findings suggest that microplastics act as vectors for the spread of ARGs, MRGs, and pathogens in aquaculture, potentially leading to the formation of complexes of these materials that threaten ecosystem health and human well-being. This study provides critical insights into the need for targeted management strategies to mitigate microplastic pollution in aquaculture settings.","PeriodicalId":361,"journal":{"name":"Journal of Hazardous Materials","volume":"12 1","pages":""},"PeriodicalIF":13.6,"publicationDate":"2025-02-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143451815","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Novel mechanisms for selenite biotransformation and selenium nanoparticles biogenesis in Acinetobacter sp. SX5 isolated from seleniferous soil","authors":"Sheng-Wei Huang, Yuan-yuan Yao, Hua-xu Zhang, Wan-ying Guo, Ming-hui Fang, Hai-bo Wang, Yu-jun Sun, Ming-hao Li","doi":"10.1016/j.jhazmat.2025.137694","DOIUrl":"https://doi.org/10.1016/j.jhazmat.2025.137694","url":null,"abstract":"The high biotoxicity of selenium (Se) has spurred research into its microbial biotransformation into less toxic Se nanoparticles (SeNPs). However, the molecular mechanisms underlying microbially driven selenite transformation remain largely unknown. In the present study, <em>Acinetobacter</em> sp. SX5, a bacterial strain with high Se reduction capacity, was isolated from soil. The biotransformation of selenite by SX5 and the molecular mechanisms underlying the formation of SeNPs were investigated. SX5 almost completely transformed 5.0<!-- --> <!-- -->mM selenite into intracellular and extracellular spherical SeNPs within 48<!-- --> <!-- -->h. Fourier-transform infrared spectroscopy indicated that lipids, proteins, and carbohydrates were present on the surface of these SeNPs. Transcriptomic data subsequently revealed the significant upregulation of genes related to redox homeostasis and arsenate, pyruvate, and butanoate metabolism pathways. Gene mutation/complementation analysis confirmed that arsenate reductase (arsC) and NAD(P)-dependent alcohol dehydrogenase (dhaT1) facilitated selenite reduction <em>in vivo</em>. <em>In vitro</em> assays found that arsC and dhaT1 catalyzed Se(IV) reduction with NADPH acting as co-factor. To the best of our knowledge, this study is the first to present evidence for the participation of arsC and dhaT1 in selenite reduction <em>in vivo</em>, providing important insights into the molecular mechanisms underlying the biotransformation of Se(IV) and the biogenesis of SeNPs using Se-reducing bacteria.","PeriodicalId":361,"journal":{"name":"Journal of Hazardous Materials","volume":"16 1","pages":""},"PeriodicalIF":13.6,"publicationDate":"2025-02-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143451811","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"PFOS causes lysosomes-regulated mitochondrial fission through TRPML1-VDAC1 and oligomerization of MCU/ATP5J2","authors":"Wei Yang, Yu Li, Ruzhen Feng, Peiyao Liang, Kefan Tian, Lingli Hu, Kejing Wang, Tianming Qiu, Jingyuan Zhang, Xiance Sun, Xiaofeng Yao","doi":"10.1016/j.jhazmat.2025.137685","DOIUrl":"https://doi.org/10.1016/j.jhazmat.2025.137685","url":null,"abstract":"Perfluorooctane sulfonate (PFOS), a listed persistent organic pollutant, poses risks to human health and is closely linked to chronic metabolic diseases. Although the role of mitochondrial fission in these diseases has garnered attention, whether and how PFOS induces mitochondrial fission remains obscure. Here, we found that PFOS induced mitochondrial fission, as demonstrated by the fragmentation of mitochondria and the upregulation of dynamin-related protein 1 (DRP1), phospho-DRP1 and mitochondrial fission protein 1 (FIS1) in human hepatocytes MIHA and mice liver. Blocking the calcium transfer from lysosomes to mitochondria that was executed by transient receptor potential mucolipin 1 (TRPML1) of lysosomes and voltage-dependent anion channel 1 (VDAC1) of mitochondria, did not affect PFOS-induced mitochondrial fission. In contrast, knockdown of TRPML1 or VDAC1 reversed this process. Knockdown of mitochondrial calcium uniporter (MCU), rather than inhibiting its activity, effectively alleviated PFOS-induced mitochondrial fission. Additionally, PFOS increased MCU oligomers without affecting MCU monomer. Inhibiting autophagy reversed the MCU oligomerization. Further investigation unveiled the interactions of MCU with VDAC1, TRPML1, mitochondrial Fo complex subunit F2 (ATP5J2) and DRP1 in PFOS-exposed mice liver and MIHA cells. We also discovered that knockdown of ATP5J2 alleviated PFOS-induced mitochondrial fission. Ulteriorly, PFOS upregulated ATP5J2 that underwent oligomerization. Knockdown of MCU reversed the increase in ATP5J2. Our study uncovers the presence and molecular basics of lysosomes-regulated mitochondrial fission under PFOS exposure, explains the regulatory pathways on MCU and ATP5J2 oligomerization and their pivotal roles in mitochondrial fission, highlighting the involvement of mitochondrial fission in PFOS-related health risks.","PeriodicalId":361,"journal":{"name":"Journal of Hazardous Materials","volume":"25 1","pages":""},"PeriodicalIF":13.6,"publicationDate":"2025-02-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143451816","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Distribution and diversity of microplastics along the aquatic food web in the largest mangrove reserve of China","authors":"Jingyu Wang, Zhaohui Zhang","doi":"10.1016/j.jhazmat.2025.137697","DOIUrl":"https://doi.org/10.1016/j.jhazmat.2025.137697","url":null,"abstract":"Knowledge of microplastics (MPs) in consumers at different trophic levels and with different feeding strategies in mangroves is essential to evaluate pathways and ecological effects from exposure to MPs. We conducted a comprehensive study on the distribution of MPs along the food web in the largest natural mangrove reserve in China, and applied diversity index of MPs, D’(MP), in terms of color, size, shape and type, to investigate complexity of MPs through the trophic cascades. The highest abundance of total MPs occurred at 5.7±2.6 items/individual in fish, followed by 4.8 ± 1.9, 3.2 ± 0.5, 2.2 ± 0.9 items/individual in crabs, bivalves and shrimps, respectively. There was a correlation between the abundance of MPs in the gastrointestinal tracts (GITs) or soft tissues of organisms and trophic levels (r=0.47, <em>p</em> &lt;0.01), while microplstic abundance were also correlated with body wet weights. The abundance and diversity of MPs in mangrove organisms were influenced by their feeding behaviors and living habitats, as consumers through indirect ingestion had significantly higher abundance of MPs than discriminate feeders. For MPs in their GITs, crabs had the highest shape D’(MP), but the lowest size D’(MP) and color D’(MP), while fish had highest color D’(MP), but significantly lower shape D’(MP). Our application of diversity index of MPs to mangrove ecosystem for the first time reveals a rather complicated distribution of MPs along the aquatic food web, demonstrating an urgent need for measures to reduce the discharge of MPs into mangrove and develop a remediation strategy.","PeriodicalId":361,"journal":{"name":"Journal of Hazardous Materials","volume":"52 1","pages":""},"PeriodicalIF":13.6,"publicationDate":"2025-02-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143451802","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Stereoselective Behavior of Naproxen Chiral Enantiomers in Promoting Horizontal Transfer of Antibiotic Resistance Genes","authors":"Shuhan Li, Yu Liu, Yi Zhang, Pan Huang, Mark Bartlam, Yingying Wang","doi":"10.1016/j.jhazmat.2025.137692","DOIUrl":"https://doi.org/10.1016/j.jhazmat.2025.137692","url":null,"abstract":"Antibiotic resistance poses a global threat to public health, with recent studies highlighting the role of non-antibiotic pharmaceuticals in the transmission of Antibiotic resistance genes (ARGs). This study provides insights into the comprehensive profile, horizontal gene transfer potential, hosts, and public health risks associated with antibiotic resistomes in river ecosystems exposed to chiral naproxen (NAP). Our findings demonstrate that NAP stress selectively enriches ARGs and mobile genetic elements (MGEs), thereby bolstering bacterial resistance to specific antibiotics. Importantly, the spatial variation of NAP chiral enantiomers influences the enantioselective response of bacterial communities to antibiotics. While (S)-NAP and (R)-NAP exhibit differing degrees of horizontal transfer potential, (S/R)-NAP notably facilitates microbial aggregation and DNA transport via type IV secretion system (T4SS)-related functional genes, promoting the conjugation of <em>sul1</em>. Moreover, (S/R)-NAP promotes the horizontal transfer of ARGs by stimulating ROS production and altering cell membrane permeability. Chiral NAP exposure induces pathogens to acquire ARGs and accelerates the proliferation of <em>Burkholderia</em>. ARG-Rank analysis indicates that the health risk posed by (R)-NAP exposure surpasses that of (S)-NAP, with the highest risk observed when both enantiomers are present. This study elucidates the horizontal transfer and transmission mechanisms of ARGs under chiral NAP stress, underscoring the potential health hazards associated with NAP chiral enantiomers.","PeriodicalId":361,"journal":{"name":"Journal of Hazardous Materials","volume":"15 1","pages":""},"PeriodicalIF":13.6,"publicationDate":"2025-02-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143451696","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Assessment of aerobic-anoxic biotrickling filtration for the desulfurization of high-strength H2S streams from sugarcane vinasse fermentation","authors":"André Do Vale Borges, Márcia Helena Rissato Zamariolli Damianovic, Raúl Muñoz Torre","doi":"10.1016/j.jhazmat.2025.137696","DOIUrl":"https://doi.org/10.1016/j.jhazmat.2025.137696","url":null,"abstract":"The increasing demand for renewable energy has heightened interest in biogas production from agro-industrial residues, such as sugarcane vinasse—a byproduct of ethanol production. During vinasse fermentation, sulfate reduction generates biogas with high hydrogen sulfide (H₂S) concentrations, reaching up to 50000 ppm_v. This study assessed the performance of two bench-scale biotrickling filters (BTFs) treating synthetic sulfide-rich acidogenic off-gas (7000 ppm_v) from mesophilic sugarcane vinasse fermentation. The systems were packed with materials of high (950 m² m^-3, BTF_H) and low (460 m² m^-3, BTF_L) specific surface areas and inoculated with sulfur-oxidizing bacteria (SOB). Operational conditions included decreasing empty bed residence times (EBRTs) of 9, 6, and 4<!-- --> <!-- -->minutes and nitrate-to-sulfur ratios of 0.1, 0.3, and 0.5, respectively. Both BTFs achieved complete H₂S removal at the shortest EBRT, with elimination capacities (ECs) exceeding 140<!-- --> <!-- -->g S-H₂S m^-3 h^-1. However, BTF_H exhibited reduced EC at higher H₂S loads due to elemental sulfur (S⁰) accumulation, resulting in clogging, pH instability, and diminished denitrification activity. Despite these challenges, the system demonstrated resilience by restoring nitrate reduction and H₂S oxidation. This study underscores the efficacy of hybrid aerobic-anoxic BTFs for treating H₂S-rich biogas and highlights the critical role of packing material selection and nitrogen-to-sulfur ratio control for long-term operational stability.","PeriodicalId":361,"journal":{"name":"Journal of Hazardous Materials","volume":"23 1","pages":""},"PeriodicalIF":13.6,"publicationDate":"2025-02-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143451814","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Electrochemical membranes for rare earth mine water treatment: sequential removal of rare earth ions and ammonia nitrogen","authors":"Zhiwei Lin, Chunhui Zhang, Peidong Su, Ping Qiao, Junqiang Guo","doi":"10.1016/j.jhazmat.2025.137668","DOIUrl":"https://doi.org/10.1016/j.jhazmat.2025.137668","url":null,"abstract":"The compound pollution caused by rare earth elements (REEs) and high concentrations of ammonia and nitrogen in the drainage water of rare earth mines poses a serious threat to water ecological safety, necessitating urgent resolution. To address this challenge, (Sb, F)-doped SnO₂-modified ceramic membranes (AFTO-CM) were developed for use in an integrated electro-flocculation-electro-oxidation-membrane separation treatment system. Physicochemical characterization revealed that AFTO-CM possesses excellent electrical conductivity (2.84 Ω/sq), electrocatalytic properties (charge transfer resistance of 1.41 Ω), operational stability (sustained performance at 30<!-- --> <!-- -->mA for over 45<!-- --> <!-- -->h), hydrophilicity (contact angle of 0°), and a porous structure. In the integrated treatment system, optimization of key factors achieved removal of REEs and ammonia nitrogen (99.84-99.98%). In addition, physicochemical characterization analyses confirmed the removal of REEs and Al³⁺ hydrolysis products through the formation of hydroxyl complexes. Product analysis further indicated that ammonia nitrogen removal primarily occurred through oxidation by free chlorine. Theoretical calculations showcased that Sb and F doping reduced the energy barrier of Cl₂ desorption in the SnO₂-based conducting layer while increasing the barrier for oxygen evolution reaction (OER) intermediates (*OOH), thus enhancing chlorine evolution reaction (CER) activity. Hence, this study provides valuable insights into the efficient purification of rare earth mine drainage.","PeriodicalId":361,"journal":{"name":"Journal of Hazardous Materials","volume":"76 1","pages":""},"PeriodicalIF":13.6,"publicationDate":"2025-02-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143451697","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Low dose of micro-/nano-plastics mixture induced cardiac hypertrophy and reductive stress: the liver-heart crosstalk and hepatic-cardiac organoids-on-a-chip","authors":"Wei Cheng, Hange Chen, Yue Zhou, Yifei You, Yan Feng, Yan Wang","doi":"10.1016/j.jhazmat.2025.137686","DOIUrl":"https://doi.org/10.1016/j.jhazmat.2025.137686","url":null,"abstract":"&lt;h2&gt;Section snippets&lt;/h2&gt;&lt;section&gt;&lt;section&gt;&lt;section&gt;&lt;h2&gt;Preparation and characterization of aPPs after artificial digestive juices treatment &lt;em&gt;in vitro&lt;/em&gt;&lt;/h2&gt;The PPs derived from plastic cap lids, were prepared and subjected to UV-aging following the methodology described in our previous study [18]. The aPPs subjected to UV-light treatment (100&lt;!-- --&gt; &lt;!-- --&gt;h and 700&lt;!-- --&gt; &lt;!-- --&gt;h) were subsequently digested using artificial digestive juices (DJ), which included oral, gastric, duodenal, and bile juices, based on formulations derived from the Chinese Pharmacopoeia and previous studies [18]. Following digestion with DJ, the aPPs were thoroughly washed and characterized in terms&lt;/section&gt;&lt;/section&gt;&lt;/section&gt;&lt;section&gt;&lt;section&gt;&lt;h2&gt;Results and Discussion&lt;/h2&gt;Firstly, the micro-/nano-plastics mixture derived from plastic caps were prepared and subjected to UV photoaging and DJ to simulate realistic PP particles to which humans are exposed. Subsequently, &lt;em&gt;in vivo&lt;/em&gt; and &lt;em&gt;in vitro&lt;/em&gt; studies were conducted to explore the potential molecular mechanism induced by low-dose of PPs in forms of liver-heart crosstalk.The PPs were irregular fragmented-shape with rough surface, the size distribution was ranged from 12 to 0.10 μm, the mean diameters decreased from 5.26&lt;/section&gt;&lt;/section&gt;&lt;section&gt;&lt;section&gt;&lt;h2&gt;Conclusion&lt;/h2&gt;In summary, the micro-/nano-plastics mixture, acquired following UV-photoageing and DJ treatment, could produce cardiac hypertrophy with reductive feature in vivo. In vitro, we have established an integrated hepatic-cardiac-organoids-on-chip model and observed accordant adverse cardiac effect. The cytokine FGF21, produced by the liver, were found to involve in the PP-induced cardiotoxicity under circumstance of liver-heart crosstalk, even at low-dose that being equivalent to human internal&lt;/section&gt;&lt;/section&gt;&lt;section&gt;&lt;section&gt;&lt;h2&gt;Environmental implication&lt;/h2&gt;&lt;ul&gt;&lt;li&gt;&lt;span&gt;1.&lt;/span&gt;&lt;span&gt;The micro-/nano-sized polypropylene (PP) mixtures derived from plastic caps, which were subjected to UV photoaging and exposure to artificial digestive juices to simulate realistic PP particles to which humans are exposed.&lt;/span&gt;&lt;/li&gt;&lt;li&gt;&lt;span&gt;2.&lt;/span&gt;&lt;span&gt;For &lt;em&gt;in vitro&lt;/em&gt;, PPs (at concentrations of 6, 60, and 600&lt;!-- --&gt; &lt;!-- --&gt;ng/mL, with the lower concentrations representing human internal exposure levels) were used.&lt;/span&gt;&lt;/li&gt;&lt;li&gt;&lt;span&gt;3.&lt;/span&gt;&lt;span&gt;For &lt;em&gt;in vivo&lt;/em&gt;, PPs were given to mice via drinking water &lt;em&gt;ad libitum&lt;/em&gt;, and the dose was 6&lt;!-- --&gt; &lt;!-- --&gt;ng/mL, when the micro-scale PP were quantified&lt;/span&gt;&lt;/li&gt;&lt;/ul&gt;&lt;/section&gt;&lt;/section&gt;&lt;section&gt;&lt;section&gt;&lt;h2&gt;CRediT authorship contribution statement&lt;/h2&gt;&lt;strong&gt;Cheng Wei:&lt;/strong&gt; Writing – original draft, Methodology, Funding acquisition, Conceptualization. &lt;strong&gt;Chen Hange:&lt;/strong&gt; Investigation, Formal analysis, Data curation. &lt;strong&gt;Zhou Yue:&lt;/strong&gt; Writing – original draft, Validation, Investigation, Data curation. &lt;strong&gt;Feng Yan:&lt;/strong&gt; Resources. &lt;s","PeriodicalId":361,"journal":{"name":"Journal of Hazardous Materials","volume":"25 1","pages":""},"PeriodicalIF":13.6,"publicationDate":"2025-02-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143451805","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}