Journal of Hazardous Materials最新文献_第3页

Tracing atmospherically deposited cadmium accumulation in rice using stable isotopes 利用稳定同位素追踪水稻大气沉积镉积累

IF 12.2 1区环境科学与生态学

Journal of Hazardous Materials Pub Date : 2025-05-06 DOI: 10.1016/j.jhazmat.2025.138524

Buyun Du , Ruizhi Xia , Daniel Obrist , Yufang Sun , Ting Wang , Jun Zhou

{"title":"Tracing atmospherically deposited cadmium accumulation in rice using stable isotopes","authors":"Buyun Du , Ruizhi Xia , Daniel Obrist , Yufang Sun , Ting Wang , Jun Zhou","doi":"10.1016/j.jhazmat.2025.138524","DOIUrl":"10.1016/j.jhazmat.2025.138524","url":null,"abstract":"<div><div>Understanding the plant uptake of atmospherically deposited cadmium (Cd) is limited. Factorial soil and atmospheric exposure experiments conducted in both field and greenhouse settings, in conjunction with stable Cd isotopes and synchrotron microscopic X-ray fluorescence (SR-μXRF), were performed to differentiate the impact of newly deposited Cd from legacy Cd in the soil. Root uptake of newly deposited Cd in soils contributed 43–48 %, 6.3–30 %, and 6.3–30 % to the leaves, stems, and grains, respectively. In contrast, foliar uptake contributed the most to rice leaves, which were subsequently limited in their translocation to stems and grains, accounting for 18–31 %, 5.7–12 %, and 5.7–11 % of Cd in leaves, stems, and grains, respectively. Stem nodes appear to restrict Cd translocation from leaves to grains while simultaneously facilitating both bi-directional xylem and phloem transport. Geochemical analyses and diffusive gradients in thin films extractions indicated that newly deposited Cd constituted the major bioavailable Cd fractions in soil solutions. In the rice growing season, the atmospherically deposited Cd only accounted 0.8–5.5 % of soil pools, but they substantially contributed 27–45 % to grains, raising important questions about how atmospheric Cd deposition may impact food security. The accumulation of Cd in rice grains from atmospheric deposition primarily occurs during the filling stage, making the management of emissions during this period crucial compared to the remediation of affected soils.</div></div>","PeriodicalId":361,"journal":{"name":"Journal of Hazardous Materials","volume":"494 ","pages":"Article 138524"},"PeriodicalIF":12.2,"publicationDate":"2025-05-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143910658","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Comparative transcriptome and physiological analyses reveal involvement of photosynthesis, phytohormone signaling, and cysteine-methionine metabolism in arsenic toxicity tolerance in Brassica napus 比较转录组和生理分析揭示了光合作用、植物激素信号和半胱氨酸-蛋氨酸代谢参与甘蓝型油菜的砷毒性耐受

IF 12.2 1区环境科学与生态学

Journal of Hazardous Materials Pub Date : 2025-05-06 DOI: 10.1016/j.jhazmat.2025.138521

Muhammad Ahsan Farooq , Fakhir Hannan , Hui-Xi Zou , Weijun Zhou , Dong-Sheng Zhao , Toqueer Abbas , Rehan Ahmad , Ahsan Ayyaz , Xiufeng Yan

{"title":"Comparative transcriptome and physiological analyses reveal involvement of photosynthesis, phytohormone signaling, and cysteine-methionine metabolism in arsenic toxicity tolerance in Brassica napus","authors":"Muhammad Ahsan Farooq , Fakhir Hannan , Hui-Xi Zou , Weijun Zhou , Dong-Sheng Zhao , Toqueer Abbas , Rehan Ahmad , Ahsan Ayyaz , Xiufeng Yan","doi":"10.1016/j.jhazmat.2025.138521","DOIUrl":"10.1016/j.jhazmat.2025.138521","url":null,"abstract":"<div><div>This study investigates the physiological, biochemical, and molecular responses of two <em>Brassica napus</em> (<em>B. napus</em>) cultivars, ZD622 and ZD630, exposed to arsenic (As) stress. ZD630 was more resistant to As-induced toxicity, as demonstrated by higher biomass retention, less chlorophyll degradation, and less impairment of photosynthetic activity than ZD622. Photosynthetic parameters like as Pn and chlorophyll fluorescence were less influenced in ZD630, indicating a higher resilience in maintaining photosynthetic machinery integrity. Ultrastructural study demonstrated that ZD630 caused less damage to cellular components such thylakoid membranes and mitochondria. Moreover, ZD630 more efficient As exclusion mechanism, as seen by decreased arsenic accumulation in aerial tissues, led to its higher stress performance. Comparative transcriptome analysis was conducted to further dissect the molecular mechanisms underlying these morpho-physiological traits. KEGG pathway analysis revealed that the pathways for photosynthesis, auxin signaling, and amino acid metabolism were overrepresented suggesting these pathways may play important roles in the differential response to As between the two cultivars. ZD630 revealed activation of genes related to photosystem II repair, auxin transport, MAPK signaling, and ABA receptors, which might contribute to its improved stress response. Additionally, the differential control of cysteine and methionine metabolism contributes to ZD630 improved capacity to detoxify As via glutathione production.</div></div>","PeriodicalId":361,"journal":{"name":"Journal of Hazardous Materials","volume":"494 ","pages":"Article 138521"},"PeriodicalIF":12.2,"publicationDate":"2025-05-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143910625","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Co-sorption of phthalate esters and Cd2+ on biochar-sulfhydryl modified montmorillonite composites 邻苯二甲酸酯和Cd2+在生物炭-巯基改性蒙脱土复合材料上的共吸附

IF 12.2 1区环境科学与生态学

Journal of Hazardous Materials Pub Date : 2025-05-06 DOI: 10.1016/j.jhazmat.2025.138526

Wenjie Li, Pengfei Mao, Xuwen Chen, Wanting Ling, Chao Qin, Yanzheng Gao

{"title":"Co-sorption of phthalate esters and Cd2+ on biochar-sulfhydryl modified montmorillonite composites","authors":"Wenjie Li, Pengfei Mao, Xuwen Chen, Wanting Ling, Chao Qin, Yanzheng Gao","doi":"10.1016/j.jhazmat.2025.138526","DOIUrl":"10.1016/j.jhazmat.2025.138526","url":null,"abstract":"<div><div>Developing efficient passivating sorption materials for the treatment of combined pollution by phthalate esters (PAEs) and Cd<sup>2+</sup> has become a critical focus in environmental protection and soil remediation. In this study, biochar-sulfhydryl modified montmorillonite composites (BC-SHMMT) were synthesized, characterized, and evaluated for the co-sorption of PAEs (DMP, DEP) and Cd<sup>2+</sup>. The integration of sulfhydryl-modified montmorillonite (MMT-SH) with biochar improved the material's surface structure, enhancing both co-sorption capacity and structural stability. Molecular dynamics simulation indicated a monolayer chemical sorption of pollutants by BC-SHMMT, in alignment with the sorption theoretical model. In the co-sorption system, the coexistence of pollutants increased the adsorption of Cd<sup>2+</sup> and decreased the sorption of PAEs. The smaller molecular size and higher diffusion coefficient of Cd<sup>2+</sup> facilitated its pore filling and interaction with oxygen-containing functional groups of the material, leading to competition with PAEs for sorption sites. Notably, the ion exchange and complexation of Cd<sup>2+</sup> adsorption by MMT-SH are pivotal in enhancing BC-SHMMT co-sorption capacity. These findings provide valuable insights into the development of eco-friendly novel materials and the improvement of co-pollution remediation efficiency.</div></div>","PeriodicalId":361,"journal":{"name":"Journal of Hazardous Materials","volume":"494 ","pages":"Article 138526"},"PeriodicalIF":12.2,"publicationDate":"2025-05-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143915379","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Organ-specific lithium accumulation and its toxic effects on female reproduction 器官特异性锂积累及其对雌性生殖的毒性作用

IF 13.6 1区环境科学与生态学

Journal of Hazardous Materials Pub Date : 2025-05-06 DOI: 10.1016/j.jhazmat.2025.138516

Qigang Fan, Yi Sun, Qingjun Shen, Yuxin Wang, Jisheng Nie, Yanbing Lin, Shuaishuai Xing, Yan Li, Benhong Xu, Jianjun Liu, Xiaoting Shen, Guangbo Qu, Jun Xie, Liqin Zeng, Huidong Zhang

{"title":"Organ-specific lithium accumulation and its toxic effects on female reproduction","authors":"Qigang Fan, Yi Sun, Qingjun Shen, Yuxin Wang, Jisheng Nie, Yanbing Lin, Shuaishuai Xing, Yan Li, Benhong Xu, Jianjun Liu, Xiaoting Shen, Guangbo Qu, Jun Xie, Liqin Zeng, Huidong Zhang","doi":"10.1016/j.jhazmat.2025.138516","DOIUrl":"https://doi.org/10.1016/j.jhazmat.2025.138516","url":null,"abstract":"Li exposure is becoming a new prominent major issue in energy-environment-health field. However, its reproductive health risk has been less explored. In this study, we find that exposure to 28-fold REED (<u>r</u>eally <u>e</u>nvironmental <u>e</u>xposure <u>d</u>ose) of Li is enough to induce mouse miscarriage by altering the structures and functions of placenta. Exposure to ≥ 5.6-fold REED of Li is enough to alter the structure and functions of ovary and placenta, and exposure to ≥ 28-fold REED of Li alters fetus morphology and uterus functions, showing a susceptibility to Li exposure as the order ovary > placenta > fetus > uterus. Some characteristics (such as AMH (anti-müllerian hormone) levels in serum, the mRNA levels of Pgr (progesterone receptor) and Nr2f2 in placenta, and the mRNA levels of Cyp19A1 and Sohlh2 in Ovary) are significantly altered with exposure to 5.6-fold REED of Li, which could be used as sensitive targets to predict reproductive health risk with Li exposure. Moreover, the doses of Li in clinical Li treatment (28- or 56-fold REED of Li) should be more cautious, especially for women. Collectively, this study identifies Li exposure as a new risk factor for female reproductive healthy in energy-environment-health field, which deserves the critical attention by governments, enterprises, and hospitals.","PeriodicalId":361,"journal":{"name":"Journal of Hazardous Materials","volume":"35 1","pages":""},"PeriodicalIF":13.6,"publicationDate":"2025-05-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143910634","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Multi-omics integration uncovers the zinc metabolic regulatory network in the hyperaccumulating ecotype of Sedum alfredii Hance 多组学整合揭示了景天超积累生态型锌代谢调控网络

IF 13.6 1区环境科学与生态学

Journal of Hazardous Materials Pub Date : 2025-05-06 DOI: 10.1016/j.jhazmat.2025.138523

M.J.I. Shohag, Qianying Yang, Zhenli He, Islam Mostafa, Sixue Chen, Xiaoe Yang

{"title":"Multi-omics integration uncovers the zinc metabolic regulatory network in the hyperaccumulating ecotype of Sedum alfredii Hance","authors":"M.J.I. Shohag, Qianying Yang, Zhenli He, Islam Mostafa, Sixue Chen, Xiaoe Yang","doi":"10.1016/j.jhazmat.2025.138523","DOIUrl":"https://doi.org/10.1016/j.jhazmat.2025.138523","url":null,"abstract":"Plants require a fine balance of zinc (Zn) for proper growth and development. This fine-tuning of Zn metabolism is tightly regulated and often challenging task for plants. Hyperaccumulating ecotype of <em>Sedum alfredii</em> Hance, a Zn hyperaccumulator form the Crassulaceae family, offers a unique model to study Zn homeostasis. To date, their complex molecular mechanisms underlying Zn regulation remain largely unknown. Here, we present a large-scale comparative investigation of Zn homeostasis networks in Zn hyperaccumulating and non-hyperaccumulating ecotypes of <em>S. alfredii.</em> By integrating transcriptomics, proteomics, metabolomics, and ionomics, we uncovered that transcriptional and translational changes play critical roles in maintaining Zn homeostasis. These adaptations include enhanced photosynthetic efficiency, improved Zn ion binding in shoots, and increased antioxidative capacities. Additionally, carbon and sulfur metabolic pathways were found to respond significantly to Zn treatment. Key components of the tricarboxylic acid (TCA) cycle, along with stress-related amino acids, fatty acids, sugars, antioxidants, and Zn-binding phenolics, were coordinately modulated under Zn exposure. This multi-omics integration provides novel insights into the functional genomics and metabolic adaptations of the Zn hyperaccumulator <em>S. alfredii and</em> will facilitate biotechnological applications of Zn hyperaccumulation traits for biofortification, phytoremediation and food crop safety.","PeriodicalId":361,"journal":{"name":"Journal of Hazardous Materials","volume":"56 1","pages":""},"PeriodicalIF":13.6,"publicationDate":"2025-05-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143910635","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Understanding silver structural rearrangement on zeolite Y for methyl iodide capture in nuclear safety system 了解Y型沸石上银结构重排对核安全系统中碘化甲酯捕获的影响

IF 12.2 1区环境科学与生态学

Journal of Hazardous Materials Pub Date : 2025-05-06 DOI: 10.1016/j.jhazmat.2025.138520

Young-Ho Cho , Keon Ho , Hyun-Chul Lee , Kyung-Min Kim , Dae Woo Kim , Chang-Ha Lee

{"title":"Understanding silver structural rearrangement on zeolite Y for methyl iodide capture in nuclear safety system","authors":"Young-Ho Cho , Keon Ho , Hyun-Chul Lee , Kyung-Min Kim , Dae Woo Kim , Chang-Ha Lee","doi":"10.1016/j.jhazmat.2025.138520","DOIUrl":"10.1016/j.jhazmat.2025.138520","url":null,"abstract":"<div><div>To enhance nuclear power safety, the adsorptive passive capture of emitted radioactive organic iodine under harsh conditions is essential. Silver states and CH<sub>3</sub>I reactive adsorption on silver zeolite Y were studied under simulated accident conditions (10 ppm CH<sub>3</sub>I at 7 bar, 0–80 % RH, and 150 °C). The roles of Ag⁺ ions, silver clusters, and external silver aggregates in silver zeolite Y during CH<sub>3</sub>I capture were analyzed. Ag⁺ ions enabled near-complete CH<sub>3</sub>I removal (<0.1 ppm), while silver clusters and external silver aggregates enhanced the overall adsorption capacity. It was also noted that the formation of <span><math><msubsup><mrow><mi>Ag</mi></mrow><mrow><mi>n</mi></mrow><mrow><mi>Y</mi><mo>+</mo></mrow></msubsup></math></span> clusters within sodalite cages could potentially block pores, leading to immediate breakthrough. Pelletized silver zeolite Y adsorbents demonstrated optimal CH<sub>3</sub>I capture capacity at sufficiently auto-reduced states. Under dry conditions, Ag⁺ ions primarily promoted light hydrocarbon by-products, whereas silver clusters contributed to the formation of heavier hydrocarbons. Humid conditions led to the weakening of adsorption affinity and rate of CH<sub>3</sub>I, along with oxygenated by-products. The findings, including silver structural rearrangement by auto-reduction, provide critical guidance for understanding the adsorption mechanism and improving the design efficiency of a nuclear containment system.</div></div>","PeriodicalId":361,"journal":{"name":"Journal of Hazardous Materials","volume":"494 ","pages":"Article 138520"},"PeriodicalIF":12.2,"publicationDate":"2025-05-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143910713","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Global impact of fire emission on ambient nitrate (NO3-) and health effects during 2005–2019 2005-2019年全球火灾排放对环境硝酸盐（NO3-）和健康影响的影响

IF 12.2 1区环境科学与生态学

Journal of Hazardous Materials Pub Date : 2025-05-05 DOI: 10.1016/j.jhazmat.2025.138509

Wenwen Sun , Dongmei Tang , Rui Li

{"title":"Global impact of fire emission on ambient nitrate (NO3-) and health effects during 2005–2019","authors":"Wenwen Sun , Dongmei Tang , Rui Li","doi":"10.1016/j.jhazmat.2025.138509","DOIUrl":"10.1016/j.jhazmat.2025.138509","url":null,"abstract":"<div><div>Smoke from fires often aggravate ambient nitrate pollution and pose significant threats to human health because nitrate showed high exposure-response coefficient. To better assess the impact of fire emissions on ambient nitrate and public health, a multi-stage model was developed to optimize fire-related ambient nitrate concentrations globally. Then, the mortalities caused by fire-sourced ambient nitrate exposure were estimated based on the health risk assessment model. The results suggest that the global annual mean fire-induced nitrate (NO<sub>3</sub><sup>-</sup>) concentration during 2005–2019 was 0.19 ± 0.14 μg/m<sup>3</sup>. Spatially, fire-related NO<sub>3</sub><sup>-</sup> showed the highest concentration in Sub-Saharan Africa (1.47 ± 0.78 μg/m<sup>3</sup>), followed by Australia (0.40 ± 0.22 μg/m<sup>3</sup>) and South America (0.30 ± 0.18 μg/m<sup>3</sup>), with the lowest level in Western Europe (0.11 ± 0.06 μg/m<sup>3</sup>), which was closely linked with burned areas and fuel consumption. Additionally, fire-related NO<sub>3</sub><sup>-</sup> levels in India (89 %), Australia (66 %), and North America (57 %) experienced rapid increases from 2005 to 2019. Unlike exposure concentrations, fire-induced mortalities were higher in China (113,372 deaths) and India (82,880 deaths) because regions with frequent fires overlapped with high population density areas in these countries. These results demonstrate the necessity of refraining from such burns to improve global air quality and mitigate health damages. Furthermore, our study challenges the traditional view and confirms that both of China and India experience the most serious fire-related nitrate health risks.</div></div>","PeriodicalId":361,"journal":{"name":"Journal of Hazardous Materials","volume":"494 ","pages":"Article 138509"},"PeriodicalIF":12.2,"publicationDate":"2025-05-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143910636","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Boosting nitrate removal efficiency via synergistic strategy: Oxygen vacancy engineering and morphological control 通过协同策略提高硝酸盐去除效率：氧空位工程和形态控制

IF 12.2 1区环境科学与生态学

Journal of Hazardous Materials Pub Date : 2025-05-05 DOI: 10.1016/j.jhazmat.2025.138514

Xiaofeng Cui, Fei Chen, Shuo Zhang, Xiang Liu, Miao Li

{"title":"Boosting nitrate removal efficiency via synergistic strategy: Oxygen vacancy engineering and morphological control","authors":"Xiaofeng Cui, Fei Chen, Shuo Zhang, Xiang Liu, Miao Li","doi":"10.1016/j.jhazmat.2025.138514","DOIUrl":"10.1016/j.jhazmat.2025.138514","url":null,"abstract":"<div><div>The nitrate reduction reaction (NO<sub>3</sub><sup>−</sup>RR) is a promising strategy for groundwater remediation. However, the development of electrocatalysts with high performance and low energy consumption remains a significant challenge. Here, we developed a new method with a dual modulation strategy involving vacancy engineering and morphology modulation engineering to synthesize rough surface nanospheres (c-Fe<sub>2</sub>O<sub>3</sub>) enriched with oxygen vacancies. The c-Fe<sub>2</sub>O<sub>3</sub> exhibits excellent catalytic performance, with a Faraday efficiency of up to 95.54 %. More importantly, this electrocatalyst simultaneously achieves high performance and low energy consumption (EC = 0.35 kWh/mol, E<sub>EO</sub> = 1.40 kWh/m<sup>3</sup>) in under low concentration. Theoretical research verify that morphology modulation enriches the reaction substrate and improves the active site utilization efficiency. Moreover, in addition to optimizing the electronic structure of Fe<sub>2</sub>O<sub>3</sub> and improving the charge transfer efficiency, the presence of oxygen vacancies (O<sub>v</sub>) provides active sites that enhance the adsorption and dissociation of NO<sub>3</sub><sup>−</sup> and reduce the energy barrier of the reaction step. This study develops a new method for preparing electrode materials that exhibit low energy consumption and high performance through a dual modulation strategy involving morphological regulation and vacancy engineering. The developed strategy also provides a broader technical route for the activity enhancement of other metal oxide catalysts.</div></div>","PeriodicalId":361,"journal":{"name":"Journal of Hazardous Materials","volume":"494 ","pages":"Article 138514"},"PeriodicalIF":12.2,"publicationDate":"2025-05-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143910640","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Perfluoroalkyl and polyfluoroalkyl substances interact with platelet glycoprotein Ibα and exacerbate thrombosis 全氟烷基和多氟烷基物质与血小板糖蛋白Ibα相互作用，加重血栓形成

IF 12.2 1区环境科学与生态学

Journal of Hazardous Materials Pub Date : 2025-05-05 DOI: 10.1016/j.jhazmat.2025.138506

Ming Liu , Weiqing Zhao , Chaoyu Ma , Muhammad Awais , Xue Chen , Yiting Feng , Tianyu Wang , Shaoyun Zhou , Yan Bai , Shuai Jiang , Dachuan Zhang , Guangheng Zhu , Xiaohong Ruby Xu , Miao Xu , Heyu Ni , Chuanbin Shen

{"title":"Perfluoroalkyl and polyfluoroalkyl substances interact with platelet glycoprotein Ibα and exacerbate thrombosis","authors":"Ming Liu , Weiqing Zhao , Chaoyu Ma , Muhammad Awais , Xue Chen , Yiting Feng , Tianyu Wang , Shaoyun Zhou , Yan Bai , Shuai Jiang , Dachuan Zhang , Guangheng Zhu , Xiaohong Ruby Xu , Miao Xu , Heyu Ni , Chuanbin Shen","doi":"10.1016/j.jhazmat.2025.138506","DOIUrl":"10.1016/j.jhazmat.2025.138506","url":null,"abstract":"<div><div>Perfluoroalkyl and polyfluoroalkyl substances (PFAS) are highly stable man-made chemicals. They have recently garnered significant attention due to their ubiquitous presence in the environment and deleterious effects on human health including cardiovascular diseases (CVDs). Thrombosis due to platelet activation is a major aspect in CVDs. However, the direct effect and underlying mechanism of PFAS on the platelets remains elusive. Here, we observed that PFAS engagement with the extracellular domain of platelet GPIbα, transduced GPIbα-driven inward signals, resulting in intracellular calcium mobilization, activation of Akt and αⅡbβ3 integrin, culminating in platelet aggregation and procoagulant platelet formation. PFAS pretreatment enhanced GPIb-mediated platelet spreading and thrombus formation under high shear conditions. PFAS-induced platelet activation was markedly decreased in <em>Gpibα</em>-deficient mice. PFAS-primed platelets drove neutrophil extracellular traps formation through GPIbα-dependent pathway. Further, PFAS-exposed mice showed heightened risk of thrombus growth and ischemic stroke. Our findings provide experimental evidence for the causal links between PFAS exposure and thrombotic CVDs. Blockade of GPIbα and the downstream pathways could be an instrumental strategy against PFAS-induced platelet activation and thrombosis.</div></div>","PeriodicalId":361,"journal":{"name":"Journal of Hazardous Materials","volume":"494 ","pages":"Article 138506"},"PeriodicalIF":12.2,"publicationDate":"2025-05-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143905676","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Sorption-desorption processes contributing to the natural attenuation of cis-1,2-dichloroethene in porous media 多孔介质中顺式-1,2-二氯乙烯自然衰减的吸附-解吸过程

IF 12.2 1区环境科学与生态学

Journal of Hazardous Materials Pub Date : 2025-05-05 DOI: 10.1016/j.jhazmat.2025.138500

Katelyn A. Anderson , Uriel Garza-Rubalcava , Mark A. Widdowson , Eric J. Suchomel , Natalie L. Cápiro , Kurt D. Pennell

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