Environmental Health最新文献

{"title":"Childhood mercury exposure and early death in Grassy Narrows First Nation, Canada: a retrospective study.","authors":"Donna Mergler, Aline Philibert, Myriam Fillion, Judy Da Silva","doi":"10.1186/s12940-025-01190-7","DOIUrl":"https://doi.org/10.1186/s12940-025-01190-7","url":null,"abstract":"<p><strong>Background: </strong>In 1962, a chloralkali plant began discharging mercury (Hg) into the Wabigoon-English River system, contaminating the territorial waters of Grassy Narrows First Nation, whose traditions, livelihood and diet centered on fish. Data from 1970 to 1997 government Hg biomonitoring programs were repatriated by Grassy Narrows. Our researcher-community partnership carried out secondary analyses to examine the association between childhood Hg exposure (between 5 and 15y) and survival to July 1, 2024.</p><p><strong>Methods: </strong>Information from the governmental biomonitoring programs and from Grassy Narrows Registry of Band members were used to create a retrospective year-based equivalent hair Hg (HHg) database, with dates of birth, sampling and death (N = 317). Apparent cause of death was reported by community members. Different approaches were used to minimize potential unmeasured confounders in examining the relation between Hg exposure and early death: (i) matched pairs (deceased/alive; same sex, year of birth (± 1) (n = 81) pairs for dissymmetry analysis, Kaplan-Meier survival analysis and Cox proportional hazards regression models (ii) Longitudinal Mixed Effects Models (LMEM) with individuals who had at least 7 year-based HHg measurements (n = 35), and (iii) trajectory techniques modelling exposure.</p><p><strong>Results: </strong>HHg measurements (n = 1031) were available for 167 boys and 150 girls. Mean age at sampling was 10.5 y (SD: 2.9); 44.2% had HHg ≥ 4 µg/g at least once. By July 1, 2024, 97 individuals (30.6%) had died (median age: 39 years (IQR: 24-49)). The Cox Hazard Ratio for HHg ≥ 4 µg/g at least once was 1.96 [1.18-3.28]. LMEM showed that HHg was 1.46 µg/g higher over the sampling period for the deceased compared to the living. Significant associations (p ≤ 0.001) were also observed for early death with respect to HHg trajectory summary scores (OR: 1.14 to 1.24; SE ≤ 0.78). Reported suicide, liver disease and cardiovascular/metabolic conditions made up 60% of all deaths.</p><p><strong>Conclusions: </strong>Early mortality in Grassy Narrows First Nation is higher than other First Nations and the non-Indigenous populations in Canada. Convergent findings from different approaches and statistical techniques support an association between childhood Hg exposure and early death. Morbidity and mortality in this community require follow-up.</p>","PeriodicalId":11686,"journal":{"name":"Environmental Health","volume":"24 1","pages":"39"},"PeriodicalIF":5.3,"publicationDate":"2025-06-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144368712","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Environmental exposure to mixtures of per- and polyfluoroalkyl substances in Northeast China: exploring links to nodular goiter and papillary thyroid carcinoma.","authors":"Ziqing Sun, Boying Liu, Rui Ding, Xin Wang, Yanyan Chen, Yi Wang","doi":"10.1186/s12940-025-01194-3","DOIUrl":"10.1186/s12940-025-01194-3","url":null,"abstract":"<p><strong>Background: </strong>Environmental exposure to per- and polyfluoroalkyl substances (PFAS) has been related to some adverse health effects. An increasing number of people are suffering from nodular goiter (NG) and papillary thyroid carcinoma (PTC), the specific types of thyroid tumors with the highest prevalence. In vivo and in vitro studies have indicated that exposure to PFAS can disrupt thyroid homeostasis and exhibit apparent endocrine-disrupting toxicity, including the decreased thyroid hormone levels and abnormal expression of thyroid-related genes. However, epidemiological evidence supporting the cause-effect relationship between PFAS exposure and the risk of NG and PTC is still lacking.</p><p><strong>Methods: </strong>We enrolled 290 participants to explore the relationship between PFAS exposure and NG/PTC risk. 21 urinary PFAS were detected by ultra-high performance liquid chromatography-triple quadrupole mass spectrometry (UPLC-MS/MS). Logistic regression, restricted cubic spline (RCS), Bayesian Kernel Machine Regression (BKMR) and quantile g-computation (qgcomp) models were adopted to examine effects of single and mixed PFAS exposure on NG/PTC risk.</p><p><strong>Results: </strong>Our data showed that perfluoroheptane sulfonate (PFHpS) (P = 0.033) and perfluorohexane sulfonate (PFHxS) (P = 0.003) levels in NG cases and perfluoroheptanoic acid (PFHpA) (P = 0.008) levels in PTC cases were significantly higher than those in the controls. After adjustment for confounders, PFHxS was significantly related to higher NG/PTC risk (all P for trend < 0.05). A remarkable non-linear association was found between PFHpA exposure and PTC risk (P-overall < 0.001, P-non-linear = 0.001). The BKMR model indicated that PFAS mixtures significantly increased NG risk, with PFHxS contributing the most (groupPIP: 0.886, condPIP: 0.658). In stratified analyses, PFAS mixtures were positively associated with NG/PTC risk in females and normal-weight subjects.</p><p><strong>Conclusion: </strong>Our results suggest that environmental exposure to PFAS mixtures may be associated with increased NG/PTC risk, and each PFAS may contribute to NG/PTC risk in very different ways. To the best of our knowledge, this is the first epidemiological study to examine effects of PFAS exposure on NG/PTC risk.</p>","PeriodicalId":11686,"journal":{"name":"Environmental Health","volume":"24 1","pages":"38"},"PeriodicalIF":5.3,"publicationDate":"2025-06-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12168296/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144309724","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Changes in the short-term relationship between air pollution and mortality in New York City, 1990-2019.","authors":"Rebecca Goldberg, Ariel Spira-Cohen, Masha Pitiranggon, Sarah Johnson, Kazuhiko Ito","doi":"10.1186/s12940-025-01171-w","DOIUrl":"10.1186/s12940-025-01171-w","url":null,"abstract":"","PeriodicalId":11686,"journal":{"name":"Environmental Health","volume":"24 1","pages":"37"},"PeriodicalIF":5.3,"publicationDate":"2025-06-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12166610/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144293550","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Carcinogenic effects of long-term exposure from prenatal life to glyphosate and glyphosate-based herbicides in Sprague-Dawley rats.","authors":"Simona Panzacchi, Eva Tibaldi, Luana De Angelis, Laura Falcioni, Rita Giovannini, Federica Gnudi, Martina Iuliani, Marco Manservigi, Fabiana Manservisi, Isabella Manzoli, Ilaria Menghetti, Rita Montella, Roberta Noferini, Daria Sgargi, Valentina Strollo, Francesca Truzzi, Michael N Antoniou, Jia Chen, Giovanni Dinelli, Stefano Lorenzetti, Alberto Mantovani, Robin Mesnage, Melissa J Perry, Andrea Vornoli, Philip J Landrigan, Fiorella Belpoggi, Daniele Mandrioli","doi":"10.1186/s12940-025-01187-2","DOIUrl":"10.1186/s12940-025-01187-2","url":null,"abstract":"<p><strong>Background: </strong>Glyphosate-based herbicides (GBHs) are the world's most widely used weed control agents. Public health concerns have increased since the International Agency for Research on Cancer (IARC) classified glyphosate as a probable human carcinogen in 2015. To further investigate the health effects of glyphosate and GBHs, the Ramazzini Institute launched the Global Glyphosate Study (GGS), which is designed to test a wide range of toxicological outcomes. Reported here are the results of the carcinogenicity arm of the GGS.</p><p><strong>Methods: </strong>Glyphosate and two GBHs, Roundup Bioflow used in the European Union (EU) and RangerPro used in the U.S., were administered to male and female Sprague-Dawley (SD) rats, beginning at gestational day 6 (via maternal exposure) through 104 weeks of age. Glyphosate was administered through drinking water at three doses: the EU acceptable daily intake (ADI) of 0.5 mg/kg body weight/day, 5 mg/kg body weight/day and the EU no-observed adverse effect level (NOAEL) of 50 mg/kg body weight/day. The two GBH formulations were administered at the same glyphosate-equivalent doses.</p><p><strong>Results: </strong>In all 3 treatment groups, statistically significant dose-related increased trends or increased incidences of benign and malignant tumors at multiple anatomic sites were observed compared to historical and concurrent controls. These tumors arose in haemolymphoreticular tissues (leukemia), skin, liver, thyroid, nervous system, ovary, mammary gland, adrenal glands, kidney, urinary bladder, bone, endocrine pancreas, uterus and spleen (hemangiosarcoma). Increased incidences occurred in both sexes. Most of these involved tumors that are rare in SD rats (background incidence < 1%) with 40% of leukemias deaths in the treated groups occurring before 52 weeks of age and increased early deaths were also observed for other solid tumors.</p><p><strong>Conclusions: </strong>Glyphosate and GBHs at exposure levels corresponding to the EU ADI and the EU NOAEL caused dose-related increases in incidence of multiple benign and malignant tumors in SD rats of both sexes. Early-life onset and mortality were observed for multiple tumors. These results provide robust evidence supporting IARC's conclusion that there is \"sufficient evidence of carcinogenicity [of glyphosate] in experimental animals\". Furthermore, our data are consistent with epidemiological evidence on the carcinogenicity of glyphosate and GBHs.</p>","PeriodicalId":11686,"journal":{"name":"Environmental Health","volume":"24 1","pages":"36"},"PeriodicalIF":5.3,"publicationDate":"2025-06-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12150505/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144257601","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Per- and polyfluoroalkyl substances (PFAS), thyroid hormones, sexual hormones and pubertal development in adolescents residing in the neighborhood of a 3M factory.","authors":"Nicolas van Larebeke, Bianca Cox, Sylvie Remy, Stefan Voorspoels, Elly Den Hond, Ann Colles, Martine Leermakers, Greet Schoeters, Veerle Verheyen","doi":"10.1186/s12940-025-01188-1","DOIUrl":"10.1186/s12940-025-01188-1","url":null,"abstract":"<p><strong>Background: </strong>Near Antwerp a 3M factory has been active since 1971 emitting PFAS, mainly PFOS, in the local environment. Production of C8 compounds was stopped in 2002, production of other PFAS continued until 2024. This study aimed to examine the association between internal PFAS concentrations and thyroid hormones, sexual hormones, and pubertal development in adolescents living in the neighborhood of the factory.</p><p><strong>Methods: </strong>We measured PFAS in serum of 146 female and 139 male adolescents. For males sex hormones (LH, testosterone, estradiol, progesterone, inhibin B, FSH) and SHBG were measured in serum. For males and females we assessed serum thyroid hormone levels (TSH, T3, T4 and T3/T4) and pubertal development parameters self-assessed through a standardized questionnaire. Associations between PFAS concentrations and effect biomarkers/health effects were assessed through Generalized Estimating Equations (GEE), using linear models for continuous outcomes, logistic models for binary outcomes, and proportional odds models for ordinal outcomes.</p><p><strong>Results: </strong>For males LH, total and bioavailable testosterone showed significant negative associations with PFHxS and PFOA. LH and bioavailable testosterone also showed significant negative associations with other PFAS compounds. SHBG showed significant positive associations with PFDA, PFNA, PFHxS, PFOS and the sum of the linear forms of PFOS, PFOA, PFNA and PFHxS. Males' length and growth spurt showed significant negative associations with PFOS, PFOA and PFAS sum parameters and length and growth spurt separately also with other PFAS compounds. For females growth spurt showed significant negative association with PFOA and a significant positive association with PFOS(branched). For both males and females body hair development showed significant negative associations with PFHxS, and, for males and females separately also with other PFAS compounds. For females, breast development showed significant negative associations with PFOA, pubertal development scale showed significant negative associations with PFOA, PFHxS, PFOS(linear) and the sum of 4 PFAS. For males, TSH showed a significant negative association with PFDA and FT3 showed significant positive associations with PFOA, PFOA and PFNA. For females, FT3 showed a significant negative association with PFOS(branched).</p><p><strong>Conclusion: </strong>We observed significant, consistent and biologically relevant associations of PFAS serum concentrations with sex hormone and SHBG levels in male adolescents. Moreover, a significant delay in physiological processes occurring in puberty was observed in females and males. Associations with thyroid hormones differed significantly by sex.</p>","PeriodicalId":11686,"journal":{"name":"Environmental Health","volume":"24 1","pages":"34"},"PeriodicalIF":5.3,"publicationDate":"2025-06-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12144784/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144247037","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Extreme heat and pediatric health in a warming world: a space-time stratified case-crossover investigation in Ontario, Canada.","authors":"Hallah Kassem, Eric Lavigne, Kate Weinberger, Michael Brauer","doi":"10.1186/s12940-025-01153-y","DOIUrl":"10.1186/s12940-025-01153-y","url":null,"abstract":"<p><strong>Background: </strong>Globally, climate change is causing frequent and severe extreme heat events (EHEs). A large body of literature links EHEs to multiple health endpoints. While children's physiology and activity patterns differ from those of adults in ways that are hypothesized to increase susceptibility to such endpoints, research gaps remain regarding the specific impacts of EHEs on child health. This study evaluated pediatric emergency healthcare utilizations associated with EHEs in Ontario.</p><p><strong>Methods: </strong>Applying a space-time stratified case-crossover design, associations between EHEs (same-day or lagged exposure to 2 consecutive days of daily maximum temperatures above percentile thresholds) and 15 causes of pediatric emergency healthcare use in Ontario, Canada from 2005 to 2015 were analysed using conditional quasi-Poisson regression. In primary analyses, EHEs were defined as two or more consecutive days with temperatures above the 99th percentile of temperature within each respective forward sortation area (FSA). Emergency healthcare use was measured using hospital admissions as an indicator of severe outcomes, and emergency department (ED) visits as a sensitive measure of outcomes.</p><p><strong>Results: </strong>Relative to non-EHE days, EHEs increased the rates of pediatric hospital admissions for respiratory illnesses by 26% (95% CI: 14-40%), asthma by 29% (16-44%); infectious and parasitic diseases by 36% (24-50%), lower respiratory infections by 50% (36-67%), and enteritis by 19% (7-32%). EHEs also increased the rates of ED visits for lower respiratory infections by 10% (0-21%), asthma by 18% (7-29%), heat-related illnesses by 211% (193-230%), heatstroke by 590% (550-622%), and dehydration by 35% (25-46%), but not for other causes. Admissions and ED visits due to injuries and transportation related injuries were negatively associated with EHEs. Neither all-cause hospital admissions nor ED visits were associated with EHEs.</p><p><strong>Conclusions: </strong>In Ontario, EHEs decreased the rates of pediatric emergency healthcare utilization for injuries and increased the rates of respiratory illnesses, asthma, heat-related illnesses, heatstroke, dehydration, infectious and parasitic diseases, lower respiratory infections, and enteritis. Tailored policies and programs that reflect the specific heat-related vulnerabilities of children to respiratory and infectious illnesses are warranted in the face of a rapidly warming climate.</p>","PeriodicalId":11686,"journal":{"name":"Environmental Health","volume":"24 1","pages":"35"},"PeriodicalIF":5.3,"publicationDate":"2025-06-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12145649/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144247025","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exposure to violence and socioeconomic deprivation in susceptibility to nitrogen dioxide on term infant birthweight in New York City.","authors":"Richard V Remigio, Heather H Burris, Jane E Clougherty","doi":"10.1186/s12940-025-01189-0","DOIUrl":"10.1186/s12940-025-01189-0","url":null,"abstract":"<p><strong>Introduction: </strong>Air pollution has been associated with adverse birth outcomes, with variation by socioeconomic position (SEP). However, it remains unknown which aspects of lower SEP - comprised of myriad physical and psychosocial stressors - may best explain observed pollution susceptibilities. Building upon previous studies that estimated joint associations of air pollution and socioeconomic deprivation on term birth weight in New York City (NYC), this study seeks to identify specific social stressors underlying that relationship.</p><p><strong>Methods: </strong>We examined records for 243,853 term births in NYC from 2007-2010. Residence-specific pregnancy-average NO₂ was estimated using NYC Community Air Survey (NYCCAS) and EPA regulatory data. Twenty-six community social stressor indicators were tested as modifiers of NO₂-birthweight associations in linear mixed-effects models, adjusting for particulate matter (PM_2.5), individual-level maternal characteristics, and other covariates. In sensitivity analyses, we also examined non-linear interactions between continuous NO₂ and census-tract level violence and deprivation terms.</p><p><strong>Results: </strong>Consistent with previous work, a 1-IQR (6.2 ppb) increase in average prenatal NO₂ exposure was associated with a 12.6 (SE = 2.7)-gram decrease in term birthweight.We observed similar values in independent models for most stressors related to violent crime or SEP and significantly lower birthweights with higher stressor exposures. In models of effect modification, however, we found that - despite lower average birthweights in high-stressor communities - NO₂-birthweight associations were weaker in higher-stressor communities, particularly for violence-related stressors. For example, in the highest-quartile communities for assault, a 1-IQR increase in NO₂ exhibited a decrement of only 7.3 g, on average, compared to 16.9 g in the lowest-assault quartile (p = .01 trend across quartiles). Exposures to non-violent stressors were not significantly associated with lower birthweights, nor modified observed NO₂-birthweight associations.</p><p><strong>Conclusions: </strong>We found significantly lower term-infant birthweights with higher NO₂ or community stressors. Counter to hypotheses, however, in communities with very high stressor exposures (esp. violent crimes), despite lower overall birthweights, associations for NO₂ were weaker than in low-stressor communities. Our results suggest a possible saturation effect in stress-pollution interactions, wherein very high stressor exposures appear to overwhelm any effects of pollution. In addition, we observed stronger effects for violent crimes, in relation to other social stressors.</p>","PeriodicalId":11686,"journal":{"name":"Environmental Health","volume":"24 1","pages":"33"},"PeriodicalIF":5.3,"publicationDate":"2025-05-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12125727/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144191621","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The role of artificial intelligence in occupational health in radiation exposure: a scoping review of the literature.","authors":"Zohreh Fazli, Mehran Sadeghi, Mohebat Vali, Parvin Ahmadinejad","doi":"10.1186/s12940-025-01186-3","DOIUrl":"10.1186/s12940-025-01186-3","url":null,"abstract":"<p><strong>Introduction: </strong>Artificial intelligence (AI) has the potential to significantly enhance workplace safety and mitigate occupational radiation exposure risks by improving the accuracy of assessment and management of these hazards. This study aims to review research on the use of AI in the assessment, monitoring, control, and protection of occupational radiation exposure.</p><p><strong>Method: </strong>This review was conducted according to the PRISMA guidelines. A comprehensive search was performed in the Web of Science, Scopus, and PubMed databases from inception to April 2024. The search strategy was designed based on the PICO principle and included keywords related to artificial intelligence, occupational exposure, radiation, and industry. The inclusion criteria explored the application of artificial intelligence in the assessment, monitoring, control, and protection against occupational radiation exposure. The quality of the included studies was evaluated using the MMAT critical appraisal tool.</p><p><strong>Result: </strong>In this review, the initial literature search in the Web of Science, Scopus, and PubMed databases identified 2920 articles. After removing duplicate references, screened based on title, keywords, and abstract, Ultimately, 59 eligible articles were selected, which utilized various artificial intelligence tools, such as expert systems, machine learning, deep learning, and other applied AI models. Of all the articles, 76% had high scores and were considered strong. These studies were categorized into three groups: supervision and assessment, detection and monitoring, protection, control, and personal protective equipment.</p><p><strong>Conclusion: </strong>The successful application of AI can potentially improve occupational radiation exposure management, but several key challenges must be addressed. These include the need for high-quality training data, interpretability of complex AI algorithms, alignment with safety standards, integration with existing systems, and the lack of interdisciplinary expertise. Addressing these research gaps through further study and collaboration will be crucial to realizing the benefits of AI in this domain, which has long been a critical concern in human and work environments.</p>","PeriodicalId":11686,"journal":{"name":"Environmental Health","volume":"24 1","pages":"32"},"PeriodicalIF":5.3,"publicationDate":"2025-05-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12082979/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144085994","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exposure to polycyclic aromatic hydrocarbons, heavy metals, and per- and polyfluoroalkyl substances and their associations with serum lipid profiles in the general Korean adult population.","authors":"Sanghee Shin, Youlim Kim, Yunsoo Choe, Su Hwan Kim, Jaelim Cho, Changsoo Kim, Kyoung-Nam Kim","doi":"10.1186/s12940-025-01185-4","DOIUrl":"https://doi.org/10.1186/s12940-025-01185-4","url":null,"abstract":"<p><strong>Background: </strong>Previous studies on associations between polycyclic aromatic hydrocarbons (PAHs) and lipid profiles are limited. We investigated the associations between urinary PAH metabolites and serum lipid profiles using a representative sample of Korean adults.</p><p><strong>Methods: </strong>This study utilized data from the Korean National Environmental Health Survey (2018-2020) (n = 2,516). The associations of PAH metabolites, heavy metals, and per- and polyfluoroalkyl substances (PFASs), which are ubiquitous pollutants, with lipid indicators and dyslipidemia types were evaluated using linear and logistic regression models, respectively. We examined the associations between a mixture of PAH metabolites, heavy metals, and PFASs and lipid profiles using quantile g-computation analyses.</p><p><strong>Results: </strong>A doubling of 1-hydroxypyrene (1-OHP) concentrations was associated with higher total cholesterol (TC) [β = 2.50 mg/dL, 95% confidence interval (CI): 1.09, 3.91], low-density lipoprotein cholesterol (LDL-C) (β = 2.39 mg/dL, 95% CI: 1.14, 3.63), and non-high-density lipoprotein cholesterol (non-HDL-C) concentrations (β = 2.13 mg/dL, 95% CI: 0.77, 3.49). A doubling of 1-OHP concentrations was also linked to higher odds of high TC [odds ratio (OR) = 1.15, 95% CI: 1.02, 1.30]. Additionally, 2-naphthol concentrations were associated with higher odds of high TC (OR = 1.14, 95% CI: 1.00, 1.29) and high LDL-C (OR = 1.27, 95% CI: 1.06, 1.51). Lead concentrations were associated with higher levels of TC, LDL-C, non-HDL-C, and high-density lipoprotein cholesterol (HDL-C), as well as with higher odds of high TC, high LDL-C, and high non-HDL-C. Mercury concentrations were associated with higher levels of TC, LDL-C, and non-HDL-C, and with higher odds of high TC. Several PFASs, such as perfluorooctanoic acid, perfluorononanoic acid, and perfluorodecanoic acid, were also associated with lipid profiles. A mixture of PAH metabolites, heavy metals, and PFASs was associated with higher TC, LDL-C, non-HDL-C, and HDL-C concentrations. This mixture was also linked to higher odds of high TC and high LDL-C.</p><p><strong>Conclusion: </strong>Concentrations of PAH metabolites, heavy metals, and PFASs were associated with unfavorable lipid profiles in the general adult population.</p>","PeriodicalId":11686,"journal":{"name":"Environmental Health","volume":"24 1","pages":"30"},"PeriodicalIF":5.3,"publicationDate":"2025-05-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12067673/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143998192","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Adverse effects and underlying mechanism of rare earth elements.","authors":"Xuemei Wang, Feiyu Wang, Lirong Yan, Zhixiang Gao, Shengbo Yang, Zhigang Su, Wenting Chen, Yanan Li, Fenghong Wang","doi":"10.1186/s12940-025-01178-3","DOIUrl":"10.1186/s12940-025-01178-3","url":null,"abstract":"<p><strong>Background: </strong>Rare earth elements (REEs) have found broad application in a range of industries, including electronics, automotive, agriculture, and healthcare. However, their widespread utilization and release into the environment pose potential risks of human exposure. Despite extensive research on REEs toxicity, the relationship between exposure and subsequent health concerns remains ambiguous. Given that the biological effects of REEs can vary based on their design and application, assessing their toxicity can be highly challenging.</p><p><strong>Objective: </strong>This review is to offer a thorough comprehension of REEs' application and toxicity, guiding future research and policy-making to safeguard public health and environmental integrity.</p><p><strong>Methods: </strong>A systematic search across PubMed, Web of Science, Cochrane Library, and Embase was conducted using the terms: (\"rare earth\" OR \"lanthanoid\") AND (\"health hazard\" OR \"toxic\" OR \"adverse health effect\"). From 5,924 initial records, 89 studies were selected through deduplication and two-stage screening to assess systemic toxicity of REEs. An additional 100 articles on REEs mechanisms and applications were incorporated via citation tracking. All selections followed PRISMA guidelines with dual-author verification to ensure rigor.</p><p><strong>Conclusion: </strong>The review emphasizes REEs' applications in various domains and documents potential environmental pathways. Furthermore, it elaborates on current processes to assess REEs-related toxicity across different model organisms and cell lines, estimating health threats posed by REEs exposure. Finally, based on the findings of both in vivo and in vitro experiments, the potential toxic mechanisms of REEs are detailed. To guide future research and policy development to safeguard public health and environmental integrity.</p>","PeriodicalId":11686,"journal":{"name":"Environmental Health","volume":"24 1","pages":"31"},"PeriodicalIF":5.3,"publicationDate":"2025-05-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12067734/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143987111","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}