Environmental Health最新文献

{"title":"Short-term attributable risk and economic burden of hospital admissions for anxiety disorders due to air pollution: a multicity time-stratified case-crossover study.","authors":"Peng Fu, Wanyanhan Jiang, Xinyi Tan, Yang Shu, Lian Yang","doi":"10.1186/s12940-025-01157-8","DOIUrl":"https://doi.org/10.1186/s12940-025-01157-8","url":null,"abstract":"<p><strong>Background: </strong>Anxiety disorders are a leading cause of severe quality of life impairment and are among the most common mental disorders globally. However, few studies have investigated the association between exposure to high levels of air pollution and an increased risk of developing anxiety disorders. This study aimed to investigate the relationship between air pollutants and hospitalisation for anxiety disorders and the associated economic burden of these hospitalisations in Sichuan, China.</p><p><strong>Methods: </strong>We collected 7,282 records of anxiety disorder hospitalisation from medical institutions across nine cities between January 1, 2017, and December 31, 2018. Concurrent meteorological and air pollution data, including temperature, humidity, PM_2.5, PM₁₀, SO₂, and CO, were obtained from 183 monitoring stations in Sichuan Province. After controlling for long-term trends, day of the week, and meteorological factors, we employed a time-stratified case-crossover design based on conditional logistic regression to assess the association between concentrations of the four pollutants (PM_2.5, PM₁₀, SO₂, and CO) and hospital admissions for anxiety disorders, with stratified analysis by age, sex, and season. The cost of hospitalisation was evaluated using the cost-of-illness method.</p><p><strong>Results: </strong>The finding indicated a positive correlation between short-term exposure to air pollutants and hospitalization rates of anxiety disorders. The effect of each 10 µg/m³ increase in airborne particulate matter (PM) and SO₂ on hospital admissions for people with anxiety disorders peaked with a lag of 5 days, and each 1 mg/m³ increase in CO had the greatest effect on the 0-7 day moving average lag, with OR values of PM_2.5:1.002 (95% CI: 1.001,1.004), PM₁₀:1.001 (95% CI: 1.000,1.002), SO₂:1.034 (95% CI: 1.020,1.047), and CO: 1.614 (95% CI: 1.247, 2.089). Air pollution increases the chances of anxiety disorders during the cold season. Furthermore, the elderly are particularly susceptible to these pollutants, which may contribute to an increased hospitalization rates of anxiety disorders (P < 0.05). The total economic cost of hospitalisation for anxiety disorders due to particulate matter pollution was ¥ 966,319 during the study period.</p><p><strong>Conclusion: </strong>Short-term exposure to PM_2.5, PM₁₀, SO_2, and CO may increase the risk of hospital admissions for anxiety disorders and impose significant financial burdens.</p>","PeriodicalId":11686,"journal":{"name":"Environmental Health","volume":"24 1","pages":"4"},"PeriodicalIF":5.3,"publicationDate":"2025-02-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143476392","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association between annual concentration of air pollutants and incidence of metabolic syndrome among Korean adults: Korean Genome and Epidemiology Study (KoGES).","authors":"Hanuel Shin, Minkyo Song, Sanghyuk Bae","doi":"10.1186/s12940-025-01158-7","DOIUrl":"10.1186/s12940-025-01158-7","url":null,"abstract":"<p><strong>Background: </strong>Air pollution is a global public health concern and incidence rates of metabolic syndrome (MetS) are increasing. To evaluate the effect of long-term air pollution exposure, we examined the association between long-term exposure to ambient air pollution and the incidences of MetS among Korean adults.</p><p><strong>Methods: </strong>We used data from the Korean Genome and Epidemiology Study's Cardiovascular Disease Association Study, a population-based cohort consisting of community-dwelling Korean adults between 2005 and 2011, who were followed up with until 2016 (n = 7,428). Air pollution exposure was estimated using the Congestion Mitigation and Air Quality model based on the participants' addresses. The participants had a physical examination at every visit during follow-up, and MetS was defined based on the National Institute of Health's National Cholesterol Education Program-Adult Treatment Panel III. We used Cox proportional hazard model to analyze the association between long-term air pollution exposure and incidences of MetS per interquartile range (IQR) increment of the annual concentration after adjusting for potential confounders using single and two-pollutant analysis.</p><p><strong>Results: </strong>The hazard ratios (HR) of MetS per IQR increment in PM_2.5, SO₂, NO₂, and CO were 1.19 (95% CI: 1.12-1.27), 1.57 (95% CI: 1.47-1.68), 1.11 (95% CI: 1.03-1.20), and 1.63 (95% CI: 1.48-1.78), respectively. The incidences of MetS components, which are high blood pressure, elevated fasting glucose, abdominal obesity, high fasting triglyceride (TG), and low fasting high-density lipoprotein (HDL-C), were significantly associated with an IQR increment especially in SO₂ and CO. In subgroup analysis, males had higher risk of MetS than females. The HR was the highest in the 60-69 year old age group for all pollutants.</p><p><strong>Conclusion: </strong>In the present study, we found that long-term ambient air pollution exposure increased the incidences of MetS and its components among Korean adults, especially in males and the elderly population.</p>","PeriodicalId":11686,"journal":{"name":"Environmental Health","volume":"24 1","pages":"3"},"PeriodicalIF":5.3,"publicationDate":"2025-02-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11818349/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143398681","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Combined effects of global DNA methylation, blood lead and total urinary arsenic levels on developmental delay in preschool children.","authors":"Yuu-Hueih Hsu, Chih-Yin Wu, Hui-Ling Lee, Ru-Lan Hsieh, Ya-Li Huang, Horng-Sheng Shiue, Ying-Chin Lin, Mei-Chieh Chen, Yu-Mei Hsueh","doi":"10.1186/s12940-024-01151-6","DOIUrl":"10.1186/s12940-024-01151-6","url":null,"abstract":"<p><p>DNA methylation is a critical step in brain development, 5-Methyl-2'-deoxycytidine (5mdC) is one of the global DNA methylation markers. Arsenic and lead exposures have been associated with neurotoxicity, which may be linked to epigenetic changes. Our research sought to investigate the correlation between 5mdC and developmental delay (DD) among preschoolers. Additionally, we assessed whether 5mdC modified the impacts of blood lead and total urinary arsenic levels on DD. We analyzed the concentrations of 5mdC, blood cadmium and lead, and total urinary arsenic in 174 children with DD and 88 healthy children. Global DNA methylation levels are expressed as the ratio 5mdC/2'-dexyguanosine (dG), called 5mdC (%). In our findings, elevated levels of blood lead and total urinary arsenic were significantly associated with DD risk among preschoolers. Furthermore, high 5mdC (%) was related with reduced risk of DD, with an odds ratio (OR) and 95% confidence interval (CI) of 0.14 (0.06 - 0.32). A notable multiplicative interaction was observed between low 5mdC (%) and elevated blood lead levels to increase OR of DD, with OR and 95% CI was 9.51 (4.18 - 21.64). The findings provide evidence of the combined effects of reduced 5mdC (%) and high blood lead concentrations, increasing the OR of DD.</p>","PeriodicalId":11686,"journal":{"name":"Environmental Health","volume":"24 1","pages":"2"},"PeriodicalIF":5.3,"publicationDate":"2025-01-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11740333/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143002289","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Integrating human biomonitoring exposure data into a primary care morbidity database: a feasibility study.","authors":"Pieter Jansen, Elly Den Hond, Katleen De Brouwere, Endale Alemayehu Ali, Hamid Yimam Hassen, Ilona Gabaret, Gijs Van Pottelbergh","doi":"10.1186/s12940-024-01152-5","DOIUrl":"10.1186/s12940-024-01152-5","url":null,"abstract":"<p><strong>Background: </strong>The detection of a local per- and polyfluoroalkyl substances (PFAS) pollution hotspot in Zwijndrecht (Belgium) necessitated immediate action to address health concerns of the local community. Several human biomonitoring (HBM) studies were initiated, gathering cross-sectional exposure data from more than 10,000 participants. The linkage of these HBM data with primary care health registries might be a useful new tool in environmental health analysis.</p><p><strong>Aim: </strong>We assessed the feasibility of linking exposure data from HBM programs to health outcomes from the Intego registry, which collects data from general practitioners' electronic health records. This feasibility study uses exposure data from one of the completed PFAS HBM studies, which included 796 individuals. We describe the separate datasets, the process of integrating the HBM data into Intego, the analysis plan and the advantages and challenges of using this method.</p><p><strong>Results: </strong>We established the integration of HBM data into the Intego primary care morbidity database, adhering to stringent privacy regulations and quality standards to ensure result integrity. Because of the modest sample size used in this feasibility study, no conclusions about the impact of PFAS on health endpoints can be drawn. However, with PFAS data from more than 10,000 residents available soon, more robust studies will be possible with this new method.</p><p><strong>Interpretation: </strong>We introduce a novel approach for assessing the impact of environmental health hazards within primary care settings. The methods outlined here not only pave the way for larger-scale projects but also offer a promising avenue for long-term environmental health monitoring.</p>","PeriodicalId":11686,"journal":{"name":"Environmental Health","volume":"24 1","pages":"1"},"PeriodicalIF":5.3,"publicationDate":"2025-01-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142926532","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The association between different timeframes of air pollution exposure and COVID-19 incidence, morbidity and mortality in German counties in 2020.","authors":"Sophie Hermanns, Erika von Schneidemesser, Alexandre Caseiro, Susanne Koch","doi":"10.1186/s12940-024-01149-0","DOIUrl":"10.1186/s12940-024-01149-0","url":null,"abstract":"<p><strong>Background: </strong>Ambient air pollution is a known risk factor for several chronic health conditions, including pulmonary dysfunction. In recent years, studies have shown a positive association between exposure to air pollutants and the incidence, morbidity, and mortality of a COVID-19 infection, however the time period for which air pollution exposure is most relevant for the COVID-19 outcome is still not defined. The aim of this study was to analyze the difference in association when varying the time period of air pollution exposure considered on COVID-19 infection within the same cohort during the first wave of the pandemic in 2020.</p><p><strong>Methods: </strong>We conducted a cross-sectional study analyzing the association between long- (10- and 2-years) and short-term (28 days, 7 days, and 2 days) exposure to NO₂ and PM_2.5 on SARS-CoV-2 incidence, morbidity, and mortality at the level of county during the first outbreak of the pandemic in spring 2020. Health data were extracted from the German national public health institute (Robert-Koch-Institute) and from the German Interdisciplinary Association for Intensive Care and Emergency Medicine. Air pollution data were taken from the APExpose dataset (version 2.0). We used negative binomial models, including adjustment for risk factors (age, sex, days since first COVID-19 case, population density, socio-economic and health parameters).</p><p><strong>Results: </strong>We found that PM_2.5 and NO₂ exposure 28 days before COVID-19 infection had the highest association with infection, morbidity as well as mortality, as compared to long-term or short-term (2 or 7 days) air pollutant exposure. A 1 μg/m³ increase in PM_2.5 was associated with a 31.7% increase in incidence, a 20.6% need for ICU treatment, a 23.1% need for mechanical ventilation, and a 55.3% increase in mortality; an increase of 1 μg/m³ of NO₂ was associated with an increase for all outcomes by 25.2 - 29.4%.</p><p><strong>Conclusions: </strong>Our findings show a positive association between PM_2.5 and NO₂ exposure and the clinical course of a SARS-CoV2 infection, with the strongest association to 28 days of exposure to air pollution. This finding provides an indication as to the primary underlying pathophysiology, and can therefore help to improve the resilience of societies by implementing adequate measures to reduce the air pollutant impact on health outcomes.</p><p><strong>Trial registration: </strong>Not applicable.</p>","PeriodicalId":11686,"journal":{"name":"Environmental Health","volume":"23 1","pages":"112"},"PeriodicalIF":5.3,"publicationDate":"2024-12-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11670380/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142892959","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Maternal multivitamin supplementation mitigates the risk of fetal congenital heart disease associated with high indoor total volatile organic compounds exposure in east china: a case-control study.","authors":"Xuehua Ruan, Wenyuan Shang, Jieru Lu, Zhuoyan Li, Jing Yang, Jinping Cheng, Yurong Wu, Kun Sun, Jing Sun","doi":"10.1186/s12940-024-01150-7","DOIUrl":"10.1186/s12940-024-01150-7","url":null,"abstract":"<p><strong>Background: </strong>Congenital heart disease (CHD) is a common birth defect. Our previous studies suggest that indoor air pollution, especially total volatile organic compounds (TVOCs), may increase fetal CHD risk, whereas vitamin and folic acid (FA) supplements in early pregnancy might offer protection against CHD. However, limited research has explored whether FA or multivitamin supplementation can mitigate the effects of TVOCs exposure on CHD.</p><p><strong>Methods: </strong>We conducted a case-control study to investigate the association between maternal nutrient supplementation, household indoor air pollutant exposure during pregnancy, and CHD in offspring. Pregnant women with 22-30 gestational weeks were recruited from two hospitals in East China between January 2016 and March 2022. A comprehensive approach was used, incorporating questionnaires to collect nutrient supplement information, blood sample analysis to detect serum folate, vitamin B12, and homocysteine (HCY) concentrations, and field investigations to assess indoor benzene, toluene, xylene, formaldehyde, and TVOCs exposures. Logistic regression analysis was performed to identify CHD risk factors, and stratified analysis was used to evaluate the combined effects of nutrient supplementation and TVOCs on CHD.</p><p><strong>Results: </strong>The study included 53 cases and 77 controls. Logistic regression analysis identified high maternal serum HCY (> 6.125 µmol/L) and high household TVOCs exposure (> 0.0165 mg/m³) as risk factors for CHD in offspring, with adjusted odds ratios of 2.98 (95% CI: 1.31-6.36) and 9.23 (95% CI: 3.78-22.53), respectively. Regular multivitamin supplementation mitigated the risk of high TVOCs exposure on fetal CHD, while the adverse effect of high serum HCY-related CHD risk was attenuated in the group with regular FA supplementation.</p><p><strong>Conclusion: </strong>Exposure to high indoor TVOCs concentrations increases the risk of fetal CHD. Regular multivitamin supplementation may reduce the adverse effects of high TVOCs exposure on fetal CHD.</p>","PeriodicalId":11686,"journal":{"name":"Environmental Health","volume":"23 1","pages":"110"},"PeriodicalIF":5.3,"publicationDate":"2024-12-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11662493/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142871733","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Air pollution is linked to cognitive decline independent of hypersensitive C-reactive protein: insights from middle-aged and older Chinese.","authors":"Li Huang, Xiangming Hu, Jia Liu, Jiajia Wang, Yingling Zhou, Guang Li, Guanghui Dong, Haojian Dong","doi":"10.1186/s12940-024-01148-1","DOIUrl":"10.1186/s12940-024-01148-1","url":null,"abstract":"<p><strong>Background: </strong>Long-term air pollution exposure and inflammation are considered to be associated with cognitive decline. However, whether air pollution exposure related cognitive decline is dependent on inflammation remains uncertain.</p><p><strong>Materials and methods: </strong>The present study collected data from China Health and Retirement Longitudinal Study (CHARLS) at baseline in 2011, with a follow up period in 2015. Concentration of air pollutants (particles with diameters ≤ 1.0 μm [PM₁], ≤ 2.5 μm [PM_2.5], ≤ 10 μm [PM₁₀], nitrogen dioxide [NO₂] and ozone [O₃]) were obtained from China High Air Pollutants (CHAP) dataset. Hypersensitive C-reactive protein (hs-CRP), a systemic inflammation marker, was measured in blood of subjects and cognitive function was assessed by standardized questionnaire.</p><p><strong>Results: </strong>A total of 6434 participants were included in the study. Lower exposure to PM_2.5, PM₁, PM₁₀ and NO₂ were associated with mitigated cognitive decline. The odds ratios (ORs) for air pollutants changes and cognitive decline and 95% confidence intervals (CIs) were as follows: PM_2.5-0.934(0.925, 0.943), PM₁- 0.945 (0.935,0.955), PM₁₀-0.977(0.972,0.982) and NO₂-0.962(0.950,0.975), respectively. Hs-CRP showed no significant correlation with cognitive decline or change in levels of air pollution. The interaction regression analyses, both unadjusted and adjusted, did not uncover any significant correlation between hs-CRP and air pollution with respect to cognitive decline. Bootstrap test exhibited no significant mediating effect of hs-CRP on the relationship between any air pollutants and cognitive decline, the indirect effects of hs-CRP in conjunction with exposure to different air pollutants were all found to be non-significant, with the following bootstrap CIs and p-values: PM_2.5-1.000([1.000,1.000], P = 0.480),PM₁-1.000([1.000,1.000], P = 0.230),PM₁₀-1.000([1.000,1.000], P = 0.650), O₃-1.000([1.000,1.000], P = 0.470), ΔNO₂-1.000([1.000,1.000], P = 0.830) .</p><p><strong>Conclusion: </strong>Ambient air pollution exposure was linked to cognitive decline independent of hs-CRP level.</p>","PeriodicalId":11686,"journal":{"name":"Environmental Health","volume":"23 1","pages":"111"},"PeriodicalIF":5.3,"publicationDate":"2024-12-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11662488/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142871731","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correction: Epidemiologic and clinical features of cyanobacteria harmful algal bloom exposures reported to the National Poison Data System, United States, 2010-2022: a descriptive analysis.","authors":"Rebecca A Bloch, Michael C Beuhler, Elizabeth D Hilborn, Grace Faulkner, Sarah Rhea","doi":"10.1186/s12940-024-01142-7","DOIUrl":"10.1186/s12940-024-01142-7","url":null,"abstract":"","PeriodicalId":11686,"journal":{"name":"Environmental Health","volume":"23 1","pages":"109"},"PeriodicalIF":5.3,"publicationDate":"2024-12-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11650831/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142834758","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Per- and polyfluoroalkyl substances, apolipoproteins and the risk of coronary heart disease in US men and women.","authors":"Lu Zhu, Binkai Liu, Yang Hu, Molin Wang, Jeremy D Furtado, Eric B Rimm, Philippe Grandjean, Qi Sun","doi":"10.1186/s12940-024-01147-2","DOIUrl":"10.1186/s12940-024-01147-2","url":null,"abstract":"<p><strong>Background: </strong>Existing evidence for associations of per- and polyfluoroalkyl substances (PFASs) with blood lipids, lipoproteins and apolipoproteins (apo), and coronary heart disease (CHD) risk is limited and inconsistent. This study aims to explore associations between plasma PFASs, blood lipoprotein subspecies defined by apolipoproteins, and CHD risk.</p><p><strong>Methods: </strong>A case-control study of CHD was conducted in the Health Professionals Follow-Up Study (HPFS) and Nurses' Health Study (NHS). Among participants initially free of cardiovascular disease at blood collection in 1994 (HPFS) or 1990 (NHS), 101 participants who developed non-fatal myocardial infarction or fatal CHD were identified and confirmed. A healthy control was matched to each case for age, smoking status, and date of blood draw. Plasma levels of perfluorohexane sulfonic acid (PFHxS), perfluorooctanoic acid (PFOA), total perfluorooctane sulfonic acid (PFOS), branched PFOS (brPFOS), linear PFOS (nPFOS), perfluorononanoic acid (PFNA), and perfluorodecanoic acid (PFDA) were measured. Conditional logistic regression and cubic spline regression models were used to examine associations between baseline PFASs and CHD risk. Linear regression models were applied to study PFAS associations with lipids and their subfractions.</p><p><strong>Results: </strong>After multivariate adjustments, total PFOS, brPFOS and nPFOS were significantly associated with increased risk of developing CHD, and HRs (95% CIs) per log(ng/mL) increment of PFASs were 3.66 (1.36-9.89), 3.68 (1.55-8.76), and 3.01 (1.16-7.86), respectively. Significant positive dose-response relationships were identified for these PFASs (P_linearity = 0.01, 0.002, 0.02, respectively). Other PFASs were not associated with CHD risk. PFNA and PFDA were positively associated with total apoE levels among HDL particles with or without apoC-III. No associations were observed for other PFASs with blood lipid subspecies. Blood lipid subfractions did not explain the association between PFOS and CHD risk.</p><p><strong>Conclusions: </strong>Plasma PFOS and its isomers were positively associated with CHD risk. These findings suggest that PFOS exposure causes public health risks that are greater than hitherto believed.</p>","PeriodicalId":11686,"journal":{"name":"Environmental Health","volume":"23 1","pages":"108"},"PeriodicalIF":5.3,"publicationDate":"2024-12-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11613683/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142767143","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The risk of thyroid cancer in relation to residential proximity to nuclear power plants: a systematic review and meta-analysis.","authors":"Susanna Abraham Cottagiri, Will King, Laura Rodriguez-Villamizar, Paul J Villeneuve","doi":"10.1186/s12940-024-01143-6","DOIUrl":"10.1186/s12940-024-01143-6","url":null,"abstract":"<p><strong>Introduction: </strong>Ionizing radiation is a human carcinogen, and there is a public concern but limited evidence that it increases the incidence of cancer among those who live near nuclear power plants (NPPs). Previous analyses of thyroid cancer in these populations have been inconsistent, and the last synthesis was published nearly a decade ago. To address these gaps, we undertook a systematic review and meta-analysis.</p><p><strong>Methods: </strong>A search strategy was developed and applied to PubMed, Scopus, and Web of Science databases. A total of 2006 publications were identified, with 11 studies of thyroid cancer incidence that met the inclusion criteria. Study quality was assessed using the Office of Health Assessment and Translation (OHAT) tool. Summary risk estimates relating residential proximity to the NPPs and thyroid cancer were generated using a random effects model. Heterogeneity in the risk estimates was assessed for study features that included: distance to the NPP, study quality, and biological sex.</p><p><strong>Results: </strong>The 11 studies were categorized as either highly (n = 8) or plausibly (n = 3) prone to bias, primarily due to the reliance on ecological study designs. The meta-analysis summary relative risk of thyroid cancer among those who live close to NPPs (defined by ≤ 25 km distance or jurisdictional areas (e.g., community, county) relative to those who lived further away was 1.09 (95% CI: 0.93-1.29). The risk estimates were higher for studies that modelled more proximal residential distances (≤ 5 km) to NPPs than larger distances (≤ 25 km and jurisdictional areas). We found that the summary risk (RR=1.29, 95% CI: 0.77-2.16) was stronger among those studies less prone to bias. A non-significant increased risk was found among both men and women, but there was no evidence of sex differences in risk.</p><p><strong>Conclusion: </strong>Overall, the findings suggest that living near a nuclear power plant increases the risk of thyroid cancer. The small number of studies on this topic, and the finding of higher risks in studies less prone to bias highlights the need for better-designed studies.</p>","PeriodicalId":11686,"journal":{"name":"Environmental Health","volume":"23 1","pages":"106"},"PeriodicalIF":5.3,"publicationDate":"2024-11-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11606113/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142754824","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}