Environmental Health最新文献

{"title":"Environmental contamination associated with biofuel production involving pesticide-coated seed corn as feedstock: a survey of community environmental and health impacts.","authors":"Kelli C Gribben, Kylie Johnson, Pierce Greenberg, Ruth Mencia, Jabeen Taiba, Kristina W Kintziger, Kaleb Michaud, Eleanor Rogan, Terra Uhing, Jesse E Bell","doi":"10.1186/s12940-025-01174-7","DOIUrl":"10.1186/s12940-025-01174-7","url":null,"abstract":"<p><strong>Background: </strong>A United States ethanol company used pesticide-coated seed corn for fuel ethanol production, resulting in highly contaminated byproducts. Improper storage and disposal of the waste led to widespread environmental contamination. Detectable levels of neonicotinoids have been found in soil, water, and air samples, raising questions about the potential impacts to the environment and human health. The study objective was to evaluate the community's perceived physical and mental health impacts and needs resulting from the contamination linked to bioenergy production by a single company.</p><p><strong>Methods: </strong>A 54-question survey was administered to households located within a 10-mile radius of the facility. Respondents could complete the paper survey and return it by mail or electronically. The general topics were household members' awareness, concerns, and perceptions of environmental and health impacts. Quantitative data were presented as frequencies and percentages, while qualitative data were grouped into themes based on keywords and summarized as counts.</p><p><strong>Results: </strong>A total of 459 respondents completed the survey, a 38% response rate. The average household size was 2.7 (SD = 1.4). Responding households were primarily single-family homes (89%) that were owned (85%), and were long-time residents (mean = 18.4 years, SD = 15.5). A total of 36% of households included children aged 18 or younger. Respondents were concerned about contaminants affecting water (82%), soil (79%), and air (72%) quality. Most respondents (74%) felt some or a lot of stress related to potentially compromised health; however, 51% did not believe they had health symptoms resulting from the contamination. The most common self-reported symptoms among primary respondents were sinus (n = 17), respiratory (n = 22), cognitive/neurological symptoms (n = 15), and allergies (n = 17). Depression and anxiety were the primary mental health symptoms reported with 31 mentions. The top community need was wanting the environment cleaned-up, including proper removal of waste and land restoration.</p><p><strong>Conclusions: </strong>This study evaluated community-level perceived impacts of environmental contamination directly related to an ethanol plant's improper handling of production waste containing pesticides. Findings can support immediate actions by state officials and community leaders and serve as a baseline for future health and environmental monitoring.</p>","PeriodicalId":11686,"journal":{"name":"Environmental Health","volume":"24 1","pages":"17"},"PeriodicalIF":5.3,"publicationDate":"2025-04-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11974023/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143794980","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association between long-term exposure to PM_2.5 and thyroid nodules in school-aged children and adolescents: a cross-sectional study in Eastern China.","authors":"Mao Liu, Pei-Hua Wang, Yun-Jie Ye, Li Shang, Yu-Ting Xia, Yang Wang, Zhen Ding, Yan Xu","doi":"10.1186/s12940-025-01172-9","DOIUrl":"10.1186/s12940-025-01172-9","url":null,"abstract":"<p><strong>Background: </strong>Long-term exposure to particulate matter with aerodynamic diameter ≤ 2.5 μm (PM_2.5) are linked to thyroid nodules in adults, but epidemiological evidence in children and adolescents and adjustments for key confounders are lacking. This study aimed to explore the association between long-term exposure to PM_2.5 and the prevalence of thyroid nodules in school-aged children and adolescents.</p><p><strong>Methods: </strong>A cross-sectional study including 10,739 primary and junior high school students was conducted in Jiangsu Province, China, in 2021. Annual PM_2.5 concentrations were estimated by a satellite based space-time model based on machine learning. Individual exposure concentrations were assigned according to the school addresses of the participants. High-resolution diagnostic ultrasound imaging was used to detect the thyroid nodules. After adjustment for covariates, the link between the two-year (2019-2020) average PM_2.5 concentrations and thyroid nodules was estimated using a generalized linear mixed-effects model. The concentration-response (C-R) curves were smoothed using a restricted cubic spline function. Stratified analyses were performed to evaluate the modification effects of covariates on associations.</p><p><strong>Results: </strong>The average age of the 10,067 participants (51.9% boys) was 11 years, with a thyroid nodule prevalence of 30.5%. A non-linear positive correlation was found between the increase in prevalence of thyroid nodules and two-year average exposure concentration of PM_2.5. The C-R relationship curve between thyroid nodules and PM_2.5 had a J-shaped structure with a threshold value of 39.7 µg/m³. Following covariates adjustment, the odds ratio (OR) and 95% confidence interval (CI) linked to thyroid nodules were 1.515 (1.199, 1.915) for per standard deviation (SD) increase in two-year average PM_2.5 concentrations (> 39.7 µg/m³). The sex-specific associations found among adults were not observed in our stratified analyses.</p><p><strong>Conclusions: </strong>Our findings demonstrated that long-term exposure to PM_2.5 was associated with a higher prevalence of thyroid nodules in children and adolescents. Strategies that consistently reduce PM_2.5 pollution levels to ease the burden of non-communicable diseases have important public health implications.</p>","PeriodicalId":11686,"journal":{"name":"Environmental Health","volume":"24 1","pages":"18"},"PeriodicalIF":5.3,"publicationDate":"2025-04-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143802834","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Serum concentrations of per- and poly-fluoroalkyl substances (PFAS) in Danish pregnant women-temporal trends during pregnancy, correlations with partners, associations with physical activity, and blood lipid concentrations.","authors":"Ida Karoline Bach Jensen, Esben Budtz-Jørgensen, Christian Lindh, Caroline Borup Roland, Signe de Place Knudsen, Jane M Bendix, Stig Molsted, Tine D Clausen, Bente Stallknecht, Ole H Mortensen, Ellen Løkkegaard, Lisbeth E Knudsen","doi":"10.1186/s12940-025-01170-x","DOIUrl":"10.1186/s12940-025-01170-x","url":null,"abstract":"<p><strong>Background: </strong>Per- and polyflouralkyl substances (PFAS) are a group of persistent chemicals used extensively in industries and consumer products due to their water-repellent properties. Studies have linked PFAS exposure to adverse health effects, and human exposure to PFAS, especially during pregnancy, is of great concern. In this study, we report how serum PFAS concentrations during pregnancy correlated with serum PFAS of partners from the same household. Further, we report how serum PFAS concentrations change during the course of pregnancy and associations between PFAS and blood lipid concentrations as well as exploratory analyses of associations between physical activity and PFAS concentrations.</p><p><strong>Methods: </strong>In this secondary analysis of data from the FitMum study conducted from 2018 to 2021, 216 healthy, pregnant women, and 110 of their partners were included. Non-fasting venous blood samples were collected from the mothers at three test visits during pregnancy and at delivery, where blood from partners were also collected. Serum samples from all timepoints were analyzed for 15 short- and long-chained PFAS using liquid chromatography triple quadrupole linear ion trap mass spectrometry. Total cholesterol, high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C) and triglyceride blood concentrations were measured at three test visits during pregnancy and at delivery. Physical activity was measured with a wrist-worn activity tracker 24/7 from inclusion before gestational age week 15 + 0 and throughout pregnancy.</p><p><strong>Results: </strong>In serum samples we detected the following PFAS: PFOS, PFOA, PFHxS, PFNA, PFDA, and PFUnDA. The maternal median concentrations at baseline were: PFOS: 4.09 ng/mL, PFOA: 0.81 ng/mL, PFHxS: 0.29 ng/mL, PFNA: 0.42 ng/mL, PFDA: 0.25 ng/mL, and PFUnDA: 0.19 ng/mL. Partner serum PFAS concentrations were 3-145% higher than maternal concentration (except for PFUnDA). PFAS concentrations correlated within couples. All PFAS decreased significantly during pregnancy (PFOS -23.1 percent 95%-CI [-31.9;-13.2] from baseline to delivery). All PFAS concentrations were associated with increased HDL-C concentrations. No associations between physical activity and maternal PFAS concentrations were found.</p><p><strong>Conclusions: </strong>Overall, serum PFAS concentrations decreased during pregnancy. PFAS concentrations within households were strongly correlated. PFAS and HDL-C concentrations were positively associated. We found no associations between physical activity and serum PFAS concentrations.</p><p><strong>Trial registration: </strong>The study was registered at ClinicalTrials.gov; NCT03679130; 20/09/2018.</p>","PeriodicalId":11686,"journal":{"name":"Environmental Health","volume":"24 1","pages":"16"},"PeriodicalIF":5.3,"publicationDate":"2025-04-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11963616/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143771521","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Maternal urinary concentrations of bisphenol A during pregnancy and birth size in children from the Odense Child Cohort.","authors":"Astrid L Beck, Elvira V Bräuner, Cecilie S Uldbjerg, Youn-Hee Lim, Henriette Boye, Hanne Frederiksen, Anna-Maria Andersson, Tina Kold Jensen","doi":"10.1186/s12940-025-01169-4","DOIUrl":"10.1186/s12940-025-01169-4","url":null,"abstract":"<p><strong>Background: </strong>Bisphenol A (BPA) is widely used in the manufacturing of plastics. BPA can pass the placental barrier and influence fetal development. Due to its estrogenic and anti-androgenic properties, BPA may contribute sex-specific differences in developmental effects. We examined associations between maternal urinary concentrations of BPA and birth size.</p><p><strong>Methods: </strong>In this cohort study of 832 mother-child pairs from the Odense Child Cohort, pregnant women provided spot urine samples at gestational week 28, which were analyzed for BPA by isotope diluted LC-MS/MS. Osmolality adjusted urinary BPA concentrations were categorized into quartiles. Mother-child characteristics were obtained from hospital records and questionnaires. Linear regression analyses examining the association between BPA concentrations and offspring birth size (weight, length, head, and abdominal circumference) were performed for the full cohort and stratified by offspring sex.</p><p><strong>Results: </strong>BPA was detected above the limit of detection in 85% of the urine samples with a median concentration of 1.33 ng/ml. In the full cohort, birth weight decreased significantly across increasing quartiles of maternal urinary BPA concentration, with the exception of the third quartile, which showed no significant association. In sex-stratified analyses, statistically significant decreases in birth weight were observed among male offspring in the highest quartile of maternal urinary BPA concentrations (β: -115 g, 95% CI: - 225, -4, p = 0.04) compared to male offspring of the lowest quartile and a possible dose-response association was suggested (p-trend = 0.06). No statistically significant associations were observed for birth weight amongst female offspring.</p><p><strong>Conclusions: </strong>Our findings suggest a negative association between maternal urinary BPA exposure and birth weight, driven by a lower birth weight in male offspring. Further research is required to explore the underlying mechanisms of BPA's possible sex-specific associations.</p>","PeriodicalId":11686,"journal":{"name":"Environmental Health","volume":"24 1","pages":"15"},"PeriodicalIF":5.3,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11960018/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143763171","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Maternal metabolomics linking prenatal exposure to fine particulate matter and birth weight: a cross-sectional analysis of the MADRES cohort.","authors":"Wu Chen, Chenyu Qiu, Jiayuan Hao, Jiawen Liao, Fred Lurmann, Nathan Pavlovic, Rima Habre, Dean P Jones, Theresa M Bastain, Carrie V Breton, Zhanghua Chen","doi":"10.1186/s12940-025-01162-x","DOIUrl":"10.1186/s12940-025-01162-x","url":null,"abstract":"<p><strong>Background: </strong>Prenatal exposure to air pollution has been associated with an increased risk of low birth weight. Disrupted metabolism may serve as an underlying mechanism, but the specific metabolic pathways involved remain unclear.</p><p><strong>Methods: </strong>In the Maternal and Developmental Risks from Environmental and Social Stressors (MADRES) study, 382 third-trimester maternal serum samples were analyzed for untargeted metabolomics using liquid chromatography with Fourier transform high-resolution mass spectrometry. Ambient concentrations of fine particulate matter (PM_2.5), particulate matter ≤ 10 μm in diameter (PM₁₀), nitrogen dioxide (NO₂), and ozone (O₃) were estimated using inverse-distance-squared weighted spatial interpolation based on daily residential histories. Birth weight was retrieved from medical records. Linear regression identified metabolomic features associated with air pollution exposure or birth weight, followed by Mummichog pathway enrichment and mediation analyses for the selected features.</p><p><strong>Results: </strong>Second-trimester PM_2.5 exposure was associated with lower birth weight. Fourteen metabolic pathways were significantly associated with second-trimester PM_2.5 exposure, with C21-steroid hormone biosynthesis and metabolism showing the most significant association. Sixteen metabolic pathways were significantly associated with birth weight, with vitamin A (retinol) metabolism being the most significantly enriched pathway. Seven pathways were associated with both PM_2.5 exposure and birth weight, including C21-steroid hormone biosynthesis and metabolism, bile acid biosynthesis, tyrosine metabolism, ascorbate (vitamin C) and aldarate metabolism, vitamin D3 (cholecalciferol) metabolism, vitamin A (retinol) metabolism, and pyrimidine metabolism. Overweight or obese women exhibited more metabolomic features and metabolic pathways associated with PM_2.5 exposure compared to underweight or normal-weight women. No associations were observed between PM₁₀, NO₂, or O₃ and birth weight.</p><p><strong>Conclusions: </strong>Maternal metabolic pathways involving steroid metabolism, oxidative stress and inflammation, vitamin metabolism, and DNA damage may link prenatal PM_2.5 exposure to lower birth weight, with overweight or obese women potentially more susceptible to these metabolic disruptions.</p>","PeriodicalId":11686,"journal":{"name":"Environmental Health","volume":"24 1","pages":"14"},"PeriodicalIF":5.3,"publicationDate":"2025-03-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11954335/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143742660","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Plasma perfluoroalkyl substances and breast cancer risk in Brazilian women: a case-control study.","authors":"Hiroaki Itoh, Kouji H Harada, Gerson Shigeaki Hamada, Zhaoqing Lyu, Tomoko Fujitani, Mariko Harada Sassa, Taiki Yamaji, Shoichiro Tsugane, Motoki Iwasaki","doi":"10.1186/s12940-025-01168-5","DOIUrl":"https://doi.org/10.1186/s12940-025-01168-5","url":null,"abstract":"<p><strong>Background: </strong>Per- and polyfluoroalkyl substances (PFAS) are persistent environmental pollutants, and have been detected in human blood. Although PFAS may increase the risk of breast cancer in humans, findings from previous epidemiological studies on the link between PFAS and breast cancer are controversial. Additionally, most studies of PFAS to date did not distinguish between isomers. Here, we examined the association of PFAS exposure and breast cancer risk in Brazilian women, who represent a racially and ethnically diverse group.</p><p><strong>Methods: </strong>We conducted a case-control study of 471 women with breast cancer and 471 matched controls attending hospitals in São Paulo, Brazil from 2001 to 2006. Plasma concentrations of PFAS congeners were measured using in-port arylation gas chromatography-isotope dilution mass spectrometry with electron capture negative ionization. Linear and branched PFAS isomers were isolated and quantified separately. We derived multivariable-adjusted odds ratios and 95% confidence intervals for breast cancer and hormone-receptor subtypes according to plasma PFAS concentration.</p><p><strong>Results: </strong>In overall analyses, higher plasma concentrations of n-perfluoroheptane sulfonate (n-PFHpS), perfluoro-3-methyl-heptane sulfonate (3 m-PFOS), and n-perfluorononanoic acid were significantly associated with increased risk of breast cancer. Adjusted odds ratios for low, medium, and high n-PFHpS concentrations were 1.00, 1.28, and 2.00 (95% confidence interval = 1.15, 3.48), respectively (P for trend = 0.015). Furthermore, plasma 3 m-PFOS concentration and total perfluorooctanoic acid concentration were significantly associated with increased risk of breast cancer among mixed-ethnicity women. In Caucasian women, a higher plasma perfluoro-4-methyl-heptane sulfonate concentration was also associated with increased risk of breast cancer. Increased plasma n-PFHpS concentration was significantly associated with higher risk of hormone receptor-positive breast cancer but not with increased risk of hormone receptor-negative breast cancer.</p><p><strong>Conclusions: </strong>Several plasma PFAS appear to increase the risk of breast cancer. Our findings suggest the importance of isomer analysis, subgroup analysis by ethnicity, and breast cancer subtype analysis for accurately characterizing this risk.</p><p><strong>Clinical trial number: </strong>Not applicable.</p>","PeriodicalId":11686,"journal":{"name":"Environmental Health","volume":"24 1","pages":"13"},"PeriodicalIF":5.3,"publicationDate":"2025-03-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11951677/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143742663","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Risk of longer-term endocrine and metabolic conditions in the Deepwater Horizon Oil Spill Coast Guard cohort study - five years of follow-up.","authors":"Hristina Denic-Roberts, Lawrence S Engel, Jeanine M Buchanich, Rachel G Miller, Evelyn O Talbott, Dana L Thomas, Jordan McAdam, Jill E Emerick, Tina Costacou, Jennifer A Rusiecki","doi":"10.1186/s12940-025-01164-9","DOIUrl":"10.1186/s12940-025-01164-9","url":null,"abstract":"<p><strong>Introduction: </strong>Long-term endocrine and metabolic health risks associated with oil spill cleanup exposures are largely unknown, despite the endocrine-disrupting potential of crude oil and oil dispersant constituents. We aimed to investigate risks of longer-term endocrine and metabolic conditions among U.S. Coast Guard (USCG) responders to the Deepwater Horizon (DWH) oil spill.</p><p><strong>Methods: </strong>Our study population included all active duty DWH Oil Spill Coast Guard Cohort members (N = 45,224). Self-reported spill exposures were ascertained from post-deployment surveys. Incident endocrine and metabolic outcomes were defined using International Classification of Diseases (9th Revision) diagnostic codes from military health encounter records up to 5.5 years post-DWH. Using Cox proportional hazards regression, we estimated adjusted hazard ratios (aHR) and 95% confidence intervals (CIs) for various incident endocrine and metabolic diagnoses (2010-2015, and separately during 2010-2012 and 2013-2015).</p><p><strong>Results: </strong>The mean baseline age was 30 years (~ 77% white, ~ 86% male). Compared to non-responders (n = 39,260), spill responders (n = 5,964) had elevated risks for simple and unspecified goiter (aHR = 2.09, 95% CI: 1.29-3.38) and disorders of lipid metabolism (aHR = 1.09, 95% CI: 1.00-1.18), including its subcategory other and unspecified hyperlipidemia (aHR = 1.10, 95% CI: 1.01-1.21). The dysmetabolic syndrome X risk was elevated only during 2010-2012 (aHR = 2.07, 95% CI: 1.22-3.51). Responders reporting ever (n = 1,068) vs. never (n = 2,424) crude oil inhalation exposure had elevated risks for disorders of lipid metabolism (aHR = 1.24, 95% CI: 1.00-1.53), including its subcategory pure hypercholesterolemia (aHR = 1.71, 95% CI: 1.08-2.72), the overweight, obesity and other hyperalimentation subcategory of unspecified obesity (aHR = 1.52, 95% CI: 1.09-2.13), and abnormal weight gain (aHR = 2.60, 95% CI: 1.04-6.55). Risk estimates for endocrine/metabolic conditions were generally stronger among responders reporting exposure to both crude oil and dispersants (vs. neither) than among responders reporting only oil exposure (vs. neither).</p><p><strong>Conclusion: </strong>In this large cohort of active duty USCG responders to the DWH disaster, oil spill cleanup exposures were associated with elevated risks for longer-term endocrine and metabolic conditions.</p>","PeriodicalId":11686,"journal":{"name":"Environmental Health","volume":"24 1","pages":"12"},"PeriodicalIF":5.3,"publicationDate":"2025-03-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11929317/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143691139","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Neuromotor effects of early-life exposure to a mixture of endocrine disruptors in Belgian preschool children.","authors":"Christophe Barrea, Patrice Dufour, Pirard Catherine, Corinne Charlier, Fanny Brevers, Anne-Simone Parent, Laurence Rousselle","doi":"10.1186/s12940-025-01156-9","DOIUrl":"10.1186/s12940-025-01156-9","url":null,"abstract":"<p><strong>Objective: </strong>Children gradually develop motor skills that enable them to move efficiently in various daily activities such as self-care, academics and sports. The impact of prenatal exposure to endocrine disruptors (EDCs) on these performances remains understudied and current results are inconsistent. This study aims at examining the neuromotor function of Belgian preschoolers exposed in utero to a mixture of some of these chemicals.</p><p><strong>Methods: </strong>From 2014 to 2016, 66 children (35 boys and 31 girls) were recruited for a longitudinal cohort study. Two polychlorinated biphenyls (PCBs) and four perfluoroalkyl substances (PFASs) were measured in cord serum. A standardized motor evaluation, the Movement Assessment Battery for Children II (MABC-II), and a clinical sensori-motor assessment examining minor neurological dysfunction were administered at 6 years of age. The impact of the mixture of EDCs on neuromotor outcome measures was evaluated using two validated statistical models. Sex-specific analyses were also conducted.</p><p><strong>Results: </strong>Using a principal component analysis, a negative association was identified between a mixture of PCB-153 and - 180 and the Total Clinical examination score in the whole population (β (95% CI) = -15.8 (-26.51; -5.09), p = 0.005). After stratification by sex, negative associations were observed between the Gross Motor score of the MABC-II test and prenatal exposure to a mixture of PFASs and PCB-180, specifically in boys. This association was consistent across both the weighted quantile sum regression model (β (95% CI) = -2.36 (-3.42; -0.62), p = 0.023) and the principal component approach (β (95% CI) = -1.09 (-2.15; -0.13), p = 0.044).</p><p><strong>Conclusion: </strong>Our findings suggest that the neuromotor function of young children is adversely influenced by prenatal exposure to toxicants in a sex-specific manner.</p>","PeriodicalId":11686,"journal":{"name":"Environmental Health","volume":"24 1","pages":"11"},"PeriodicalIF":5.3,"publicationDate":"2025-03-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11912637/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143647763","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Per- and poly-fluoroalkyl substances (PFAS) in circulation in a Canadian population: their association with serum-liver enzyme biomarkers and piloting a novel method to reduce serum-PFAS.","authors":"Jennifer J Schlezinger, Anila Bello, Kelsey M Mangano, Kushal Biswas, Paridhiben P Patel, Emily H Pennoyer, Thomas M S Wolever, Wendy J Heiger-Bernays, Dhimiter Bello","doi":"10.1186/s12940-025-01165-8","DOIUrl":"10.1186/s12940-025-01165-8","url":null,"abstract":"<p><p>Extensive use of per- and polyfluoroalkyl substances (PFAS) has resulted in their ubiquitous presence in human blood. PFAS exposures have been associated with multiple adverse human health effects. Biomonitoring studies have focused on long-chain PFASs, but these are being replaced by short-chain PFASs or with alternate PFAS chemistries (or replacement chemistries such as GenX), resulting in changes in human exposures with time. Here, we take advantage of serum samples collected as part of a clinical trial testing the efficacy of a dietary fiber intervention to reduce serum cholesterol to investigate exposure to PFASs in Canadian participants. Serum samples were collected from 72 participants (adult males with elevated cholesterol) in 2019-2020 at baseline and after 4 weeks of the intervention and were analyzed for 17 PFASs. The highest geometric mean serum concentrations of PFAS measured at baseline corresponded to PFOSA (7.1 ng/ml), PFOS (4.2, ng/ml), PFOA (1.8 ng/ml) and PFHxS (1.3 ng/ml). Four long-chain PFASs (PFOA, PFOS, PFOSA and PFHxS) and two short-chain PFASs (PFBA, PFHxA) were detected in 100% of participants. GenX was detected in 71% of participants. Analyses of associations between serum-PFAS concentrations and biomarkers of adverse health outcomes showed the PFBA, PFHxA, PFDA and PFOSA were associated with higher serum gamma-glutamyl transferase concentrations but not with measures of serum-total or low-density lipoprotein cholesterol. Comparison of PFAS concentrations at baseline and after a 4-week follow-up showed that the total PFAS detected decreased in both the control and cholesterol intervention groups. However, the suite of long-chain PFASs of concern identified by the United States National Academies of Sciences, Engineering, and Medicine, significantly decreased only in the cholesterol intervention group. This observation suggests that a sustained dietary fiber intervention may reduce long-chain PFAS body burden, but future intervention studies need to control for PFAS exposure sources and extend the dietary supplement intake beyond 4 weeks. Overall, the results show that exposures to short-chain and replacement chemistry PFASs are common in this Canadian population.</p>","PeriodicalId":11686,"journal":{"name":"Environmental Health","volume":"24 1","pages":"10"},"PeriodicalIF":5.3,"publicationDate":"2025-03-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11909942/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143633608","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Domestic water hardness, genetic risk, and distinct phenotypes of cardiovascular disease.","authors":"Feng Tian, Genfeng Yu, Mengyuan Yang, Ying Sun, Zihao Gui, Xiaoyu Zhao, Ningjian Wang, Heng Wan, Xuetao Peng","doi":"10.1186/s12940-025-01166-7","DOIUrl":"10.1186/s12940-025-01166-7","url":null,"abstract":"<p><strong>Aims: </strong>The study aimed to investigate the association between domestic water hardness and the incidence of AF and the interaction effects between water hardness and genetic susceptibility to incident AF risk. As a secondary objective, its associations with incident heart failure (HF), coronary heart disease (CHD), and stroke were measured.</p><p><strong>Methods: </strong>The UK Biobank is a prospective cohort study comprising over 500,000 participants recruited in the United Kingdom between 2006 and 2010, aged 37 to 73 years. A total of 447,950 participants did not have prevalent AF, and 423,946 participants who were free of HF, CHD, and stroke at baseline were included. Water hardness was assessed by CaCO₃ concentration. The genetic risk score for AF was based on the standard polygenic risk score. Cox proportional hazards regression models and restricted cubic spline (RCS) analysis were conducted.</p><p><strong>Results: </strong>During a median follow-up of 13.74 years, 30,726 (6.86%) individuals were diagnosed with AF for the first time. Compared with those with water hardness ≤ 60 mg/L, individuals with domestic water hardness 121-180 mg/L had a 17% lower risk of developing AF (HR 0.83, 95% CI 0.79-0.87), but water hardness of 61-120 mg/L and > 180 mg/L was associated with a higher risk of incident AF (both 1.04, 1.01-1.07). A non-linear relationship between water hardness and incident AF (P for non-linear = 0.001) was found. Individuals with water hardness 121-180 mg/L were also significantly associated with a lower risk of incident HF (HR 0.82, 95% CI 0.75-0.89), CHD (HR 0.80, 95% CI 0.76-0.84) and stroke (HR 0.88, 95% CI 0.81-0.95). There were no significant interaction effects between water hardness level and genetic susceptibility to AF, HF, CHD, and stroke risk (all P for interaction > 0.05).</p><p><strong>Conclusion: </strong>Potential U-shaped associations between domestic water hardness and incident AF across varying levels of genetic risk were found. Hard water (121-180 mg/L) may offer the most benefits compared to soft water when considering overall cardiovascular health, including AF, HF, CHD, and stroke.</p>","PeriodicalId":11686,"journal":{"name":"Environmental Health","volume":"24 1","pages":"9"},"PeriodicalIF":5.3,"publicationDate":"2025-03-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11907801/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143633604","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}