Environmental Health最新文献

{"title":"The burden and trend prediction of ischemic heart disease associated with lead exposure: Insights from the Global Burden of Disease study 2021.","authors":"Yunfa Ding, Anxia Deng, Teng Fei Qi, Hao Yu, Liang Ping Wu, Hongbin Zhang","doi":"10.1186/s12940-025-01155-w","DOIUrl":"https://doi.org/10.1186/s12940-025-01155-w","url":null,"abstract":"<p><strong>Aim: </strong>The purpose of this study was to quantify the global burden of ischemic heart disease associated with lead exposure, utilizing data from the Global Burden of Disease (GBD) Study, 2021.</p><p><strong>Methods: </strong>Data on the burden of ischemic heart disease (IHD) associated with lead exposure were compiled globally from 1990 to 2021. These data were further stratified by dimensions including gender, age, GBD regions, and countries. Utilizing the Joinpoint regression model, we analyzed long-term trends in the burden of IHD disease associated with lead exposure and derived estimated annual percentage changes (EAPC). For future projections, we used an ARIMA model to predict potential trends in the burden of IHD disease associated with lead exposure over the next decade.</p><p><strong>Results: </strong>The study's findings reveal that in 2021, there were 590,370 deaths attributed to IHD (95% UI (Uncertainty interval (UI) is derived from the Bayesian school of statistical analysis used in the GBD studies. Unlike the frequency school of thought, which constructs confidence intervals (CI), the Bayesian school of thought views probability as a measure of confidence in an event, and in this approach the actual mean is viewed as a random variable dependent on the data and prior knowledge, with UI indicating that there is a specific probability (e.g., 95%) that the actual mean will fall within the interval.): -83,778 to 1,233,628) and 11,854,661 disability-adjusted life years (DALYs) (95% UI: -1,668,553 to 24,791,275) globally due to lead exposure, reflecting an increasing and then stabilizing trend from 1990 to 2021. Comparative analysis across study regions indicated a higher disease burden for IHD in regions with lower Socio-Demographic Index (SDI) values, contrasting with the lower burden in regions with higher SDI values. Furthermore, IHD mortality and DALYs peak in the 70-80 age cohort, with males exhibiting higher rates compared to females. Decadal projections indicate a downward trend in IHD mortality and DALYs for regions with higher SDI, in contrast to an anticipated upward trend in regions with lower SDI.</p><p><strong>Conclusion: </strong>The global burden of ischemic heart disease associated with lead exposure is increasing, particularly in regions with low SDI values and within the elderly population. Considering the profound threat posed by lead exposure to the global burden of IHD, there is an imperative to consistently reinforce and execute robust prevention strategies to mitigate environmental lead exposure.</p>","PeriodicalId":11686,"journal":{"name":"Environmental Health","volume":"24 1","pages":"23"},"PeriodicalIF":5.3,"publicationDate":"2025-04-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12013041/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143985709","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Associations between dietary exposure to profiles of metalloestrogens and estrogen-receptor positive breast cancer risk in the French E3N cohort.","authors":"Florian Saint-Martin, Chloé Marques, Xuan Ren, Emeline Lequy, Francesca Romana Mancini, Pauline Frénoy","doi":"10.1186/s12940-025-01167-6","DOIUrl":"https://doi.org/10.1186/s12940-025-01167-6","url":null,"abstract":"<p><p>Metalloestrogens are ionic metals and metalloids that can activate estrogen receptor, and are suspected to play a role in breast cancer occurrence. This study explored the relationship between dietary exposure profiles to metalloestrogens and estrogen-receptor positive breast cancer (ERP-BC) risk among women in the French E3N cohort.A prospective study was conducted involving 66 722 women who completed a food frequency questionnaire in 1993. Food consumption data were combined with food contamination data obtained from the Second French Total Diet Study, to estimate the dietary intake of 14 metalloestrogens. A principal component analysis was performed to identify the main dietary exposure profiles to metalloestrogens. The retained principal components were included in Cox regression models, used to estimate Hazard Ratios (HR) and their 95% confidence intervals (95% CI) for the associations between the adherence to the identified profiles and ERP-BC risk identified until 2014, adjusted for confounding factors selected using a directed acyclic graph.After an average follow-up of 17.7 years, 3 739 incident cases of ERP-BC were identified. Four principal components were retained, explaining 80.5% of the variance. A statistically significant positive association between the third principal component, mainly characterized by dietary intake of inorganic arsenic and vanadium, and ERP-BC risk was estimated (HR: 1.04, 95% CI: 1.00-1.07, p-value: 0.03). No statistically significant association was found when evaluating the effect of each metalloestrogen individually.The results suggests that even relatively low levels of exposure to inorganic arsenic and vanadium, when combined, could increase the risk of ERP-BC.</p>","PeriodicalId":11686,"journal":{"name":"Environmental Health","volume":"24 1","pages":"22"},"PeriodicalIF":5.3,"publicationDate":"2025-04-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12007364/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143987668","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sex differences in the impact of extreme heat on cardiovascular disease outcomes: a systematic review and meta-analysis.","authors":"Yusheng Zhou, Léa Larochelle, Fahima Afsari Khan, Louise Pilote","doi":"10.1186/s12940-025-01175-6","DOIUrl":"https://doi.org/10.1186/s12940-025-01175-6","url":null,"abstract":"<p><strong>Background: </strong>Climate change is intensifying extreme heat events, posing significant risks to cardiovascular health. While sex differences in heat vulnerability have been observed, the evidence remains inconsistent. This systematic review and meta-analysis examined sex-specific associations between extreme heat exposure and cardiovascular disease (CVD) outcomes over the past decade.</p><p><strong>Methods: </strong>We searched PubMed, Embase, and Scopus for studies published between 2004 and 2024 that reported sex-stratified cardiovascular outcomes associated with heat exposure following the PRISMA guidelines. The quality of the evidence was evaluated following the Navigation Guide Criteria. Random-effects meta-analysis was conducted to calculate pooled relative risk ratios (RRR) comparing males to females for studies addressing incremental temperature increase. Heat wave studies were synthesized narratively due to methodological heterogeneity.</p><p><strong>Results: </strong>Of 6126 articles, 79 met inclusion criteria (62 in meta-analysis, 17 in narrative synthesis), primarily from East Asia, Europe, and North America. A 1 °C temperature increase was associated with elevated cardiovascular risks for both sexes. The pooled relative risk ratio (RRR) comparing males to females was 1.008 [1.002-1.014] for mortality, suggesting slightly higher female vulnerability, but not for morbidity (RRR 0.996 [0.987-1.004]). Significant heterogeneity was noted (Mortality I² = 50.3%, Morbidity I² = 70.3%). Heat wave studies showed inconsistent sex-specific impacts across populations.</p><p><strong>Conclusions: </strong>Females showed marginally higher vulnerability to heat-related cardiovascular mortality compared to males, while no significant sex differences were observed for morbidity outcomes. Future research should focus on understanding these mechanisms and developing sex-specific interventions.</p>","PeriodicalId":11686,"journal":{"name":"Environmental Health","volume":"24 1","pages":"20"},"PeriodicalIF":5.3,"publicationDate":"2025-04-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11992858/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143984696","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Spatial distribution of acute myeloid leukaemia in Denmark.","authors":"Rikke Hedegaard Jensen, Christian Teglgaard, Lars Hernández Nielsen, Lise Dueholm Bertelsen, Heidi Søgaard Christensen, Martin Bøgsted, Marianne Tang Severinsen","doi":"10.1186/s12940-025-01177-4","DOIUrl":"https://doi.org/10.1186/s12940-025-01177-4","url":null,"abstract":"<p><strong>Background: </strong>Although various occupational and environmental exposures are suspected risk factors for acute myeloid leukaemia (AML), the aetiology of AML is largely unknown. We present an analysis of the spatial distribution of AML in Denmark on an unprecedented, detailed scale. Such investigations have the potential to uncover geographical areas of increased risk, which may in turn be tied to environmental or occupational exposures.</p><p><strong>Methods: </strong>Individuals diagnosed with AML during 2000-2020 were obtained from the Danish National Acute Leukaemia Registry and assigned to a parish based on their residence six months prior to diagnosis. The incidence rate ratio (IRR) by parish was calculated as the ratio between the age- and sex-standardised incidence rate and the national incidence rate. The IRRs were smoothed using a spatial Poisson distributed generalised linear mixed model with a conditional autoregressive correlation structure. Parishes with a smoothed IRR > 1.10 with a posterior probability > 75% were considered to have an increased risk of AML.</p><p><strong>Results: </strong>The study included 5,177 AML cases. The spatial model showed a homogeneous distribution of AML in Denmark with no parishes having an increased risk.</p><p><strong>Conclusion: </strong>The study indicates that the risk of developing AML in Denmark is not affected by place of residence, suggesting that if an unknown environmental or occupational risk factor is present, it does not seem to be associated with specific areas.</p>","PeriodicalId":11686,"journal":{"name":"Environmental Health","volume":"24 1","pages":"21"},"PeriodicalIF":5.3,"publicationDate":"2025-04-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11992828/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143973420","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of early life exposure to heat and cold on linguistic development in two-year-old children: findings from the ELFE cohort study.","authors":"Guillaume Barbalat, Ariane Guilbert, Lucie Adelaïde, Marie-Aline Charles, Ian Hough, Ludivine Launay, Itai Kloog, Johanna Lepeule","doi":"10.1186/s12940-025-01173-8","DOIUrl":"https://doi.org/10.1186/s12940-025-01173-8","url":null,"abstract":"<p><strong>Background: </strong>A number of negative developmental outcomes in response to extreme temperature have been documented. Yet, to our knowledge, environmental research has left the question of the effect of temperature on human neurodevelopment largely unexplored. Here, we aimed to investigate the effect of ambient temperature on linguistic development at the age of 2 years-old.</p><p><strong>Methods: </strong>We used data from the prospective national French birth cohort ELFE (N = 12,163) and highly-resolved exposure models with daily temporal resolution and 200 m to 1 km spatial resolution. We investigated the effect of weekly averages of overall, daytime and night-time temperature in the prenatal (first 30 weeks of gestation) and postnatal (91 weeks after birth) period on vocabulary production scores from the MacArthur-Bates Communicative Development Inventories (MB-CDI) at 2 years-old. Exposure-response and lag-response relationships were modeled with confounder-adjusted distributed lag non-linear models.</p><p><strong>Results: </strong>Scores at the MB-CDI decreased by 3.2% (relative risk (RR) 0.968, 95% confidence interval (CI): 0.939-0.998) following exposure to severe night-time heat of 15.6 °C (95th percentile) vs. 8.3 °C (median) throughout gestational weeks 14 to 19. In the postnatal period, scores at the MB-CDI decreased by 14.8% (RR 0.852; 95% CI: [0.756-0.96]) for severe overall heat of 21.9 °C (95th percentile) vs. 11.5 °C (median) throughout weeks 1 to 28. Consistent results were found for daytime and night-time heat. We observed positive effects of overall and night-time heat in the first few weeks of pregnancy. Night-time cold in the pre-natal period also resulted in improved scores at the MB-CDI. Adjusting our models for air pollutants (PM2.5, PM10 and NO2) tended to confirm these observations. Finally, there were no significant differences in temperature effects between boys and girls.</p><p><strong>Conclusion: </strong>In this large cohort study, we showed a negative impact of hot temperatures during pregnancy and after birth on language acquisition. Positive associations observed in the first few weeks of pregnancy are likely the results of methodological artifacts. Positive associations with night-time cold during the prenatal period are likely truly protective, as colder temperatures may encourage staying indoors at a comfortable temperature. Policymakers should consider neurodevelopment impairments as a deleterious effect of climate change.</p>","PeriodicalId":11686,"journal":{"name":"Environmental Health","volume":"24 1","pages":"19"},"PeriodicalIF":5.3,"publicationDate":"2025-04-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11980264/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143985708","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Environmental contamination associated with biofuel production involving pesticide-coated seed corn as feedstock: a survey of community environmental and health impacts.","authors":"Kelli C Gribben, Kylie Johnson, Pierce Greenberg, Ruth Mencia, Jabeen Taiba, Kristina W Kintziger, Kaleb Michaud, Eleanor Rogan, Terra Uhing, Jesse E Bell","doi":"10.1186/s12940-025-01174-7","DOIUrl":"10.1186/s12940-025-01174-7","url":null,"abstract":"<p><strong>Background: </strong>A United States ethanol company used pesticide-coated seed corn for fuel ethanol production, resulting in highly contaminated byproducts. Improper storage and disposal of the waste led to widespread environmental contamination. Detectable levels of neonicotinoids have been found in soil, water, and air samples, raising questions about the potential impacts to the environment and human health. The study objective was to evaluate the community's perceived physical and mental health impacts and needs resulting from the contamination linked to bioenergy production by a single company.</p><p><strong>Methods: </strong>A 54-question survey was administered to households located within a 10-mile radius of the facility. Respondents could complete the paper survey and return it by mail or electronically. The general topics were household members' awareness, concerns, and perceptions of environmental and health impacts. Quantitative data were presented as frequencies and percentages, while qualitative data were grouped into themes based on keywords and summarized as counts.</p><p><strong>Results: </strong>A total of 459 respondents completed the survey, a 38% response rate. The average household size was 2.7 (SD = 1.4). Responding households were primarily single-family homes (89%) that were owned (85%), and were long-time residents (mean = 18.4 years, SD = 15.5). A total of 36% of households included children aged 18 or younger. Respondents were concerned about contaminants affecting water (82%), soil (79%), and air (72%) quality. Most respondents (74%) felt some or a lot of stress related to potentially compromised health; however, 51% did not believe they had health symptoms resulting from the contamination. The most common self-reported symptoms among primary respondents were sinus (n = 17), respiratory (n = 22), cognitive/neurological symptoms (n = 15), and allergies (n = 17). Depression and anxiety were the primary mental health symptoms reported with 31 mentions. The top community need was wanting the environment cleaned-up, including proper removal of waste and land restoration.</p><p><strong>Conclusions: </strong>This study evaluated community-level perceived impacts of environmental contamination directly related to an ethanol plant's improper handling of production waste containing pesticides. Findings can support immediate actions by state officials and community leaders and serve as a baseline for future health and environmental monitoring.</p>","PeriodicalId":11686,"journal":{"name":"Environmental Health","volume":"24 1","pages":"17"},"PeriodicalIF":5.3,"publicationDate":"2025-04-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11974023/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143794980","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association between long-term exposure to PM_2.5 and thyroid nodules in school-aged children and adolescents: a cross-sectional study in Eastern China.","authors":"Mao Liu, Pei-Hua Wang, Yun-Jie Ye, Li Shang, Yu-Ting Xia, Yang Wang, Zhen Ding, Yan Xu","doi":"10.1186/s12940-025-01172-9","DOIUrl":"10.1186/s12940-025-01172-9","url":null,"abstract":"<p><strong>Background: </strong>Long-term exposure to particulate matter with aerodynamic diameter ≤ 2.5 μm (PM_2.5) are linked to thyroid nodules in adults, but epidemiological evidence in children and adolescents and adjustments for key confounders are lacking. This study aimed to explore the association between long-term exposure to PM_2.5 and the prevalence of thyroid nodules in school-aged children and adolescents.</p><p><strong>Methods: </strong>A cross-sectional study including 10,739 primary and junior high school students was conducted in Jiangsu Province, China, in 2021. Annual PM_2.5 concentrations were estimated by a satellite based space-time model based on machine learning. Individual exposure concentrations were assigned according to the school addresses of the participants. High-resolution diagnostic ultrasound imaging was used to detect the thyroid nodules. After adjustment for covariates, the link between the two-year (2019-2020) average PM_2.5 concentrations and thyroid nodules was estimated using a generalized linear mixed-effects model. The concentration-response (C-R) curves were smoothed using a restricted cubic spline function. Stratified analyses were performed to evaluate the modification effects of covariates on associations.</p><p><strong>Results: </strong>The average age of the 10,067 participants (51.9% boys) was 11 years, with a thyroid nodule prevalence of 30.5%. A non-linear positive correlation was found between the increase in prevalence of thyroid nodules and two-year average exposure concentration of PM_2.5. The C-R relationship curve between thyroid nodules and PM_2.5 had a J-shaped structure with a threshold value of 39.7 µg/m³. Following covariates adjustment, the odds ratio (OR) and 95% confidence interval (CI) linked to thyroid nodules were 1.515 (1.199, 1.915) for per standard deviation (SD) increase in two-year average PM_2.5 concentrations (> 39.7 µg/m³). The sex-specific associations found among adults were not observed in our stratified analyses.</p><p><strong>Conclusions: </strong>Our findings demonstrated that long-term exposure to PM_2.5 was associated with a higher prevalence of thyroid nodules in children and adolescents. Strategies that consistently reduce PM_2.5 pollution levels to ease the burden of non-communicable diseases have important public health implications.</p>","PeriodicalId":11686,"journal":{"name":"Environmental Health","volume":"24 1","pages":"18"},"PeriodicalIF":5.3,"publicationDate":"2025-04-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11974047/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143802834","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Serum concentrations of per- and poly-fluoroalkyl substances (PFAS) in Danish pregnant women-temporal trends during pregnancy, correlations with partners, associations with physical activity, and blood lipid concentrations.","authors":"Ida Karoline Bach Jensen, Esben Budtz-Jørgensen, Christian Lindh, Caroline Borup Roland, Signe de Place Knudsen, Jane M Bendix, Stig Molsted, Tine D Clausen, Bente Stallknecht, Ole H Mortensen, Ellen Løkkegaard, Lisbeth E Knudsen","doi":"10.1186/s12940-025-01170-x","DOIUrl":"10.1186/s12940-025-01170-x","url":null,"abstract":"<p><strong>Background: </strong>Per- and polyflouralkyl substances (PFAS) are a group of persistent chemicals used extensively in industries and consumer products due to their water-repellent properties. Studies have linked PFAS exposure to adverse health effects, and human exposure to PFAS, especially during pregnancy, is of great concern. In this study, we report how serum PFAS concentrations during pregnancy correlated with serum PFAS of partners from the same household. Further, we report how serum PFAS concentrations change during the course of pregnancy and associations between PFAS and blood lipid concentrations as well as exploratory analyses of associations between physical activity and PFAS concentrations.</p><p><strong>Methods: </strong>In this secondary analysis of data from the FitMum study conducted from 2018 to 2021, 216 healthy, pregnant women, and 110 of their partners were included. Non-fasting venous blood samples were collected from the mothers at three test visits during pregnancy and at delivery, where blood from partners were also collected. Serum samples from all timepoints were analyzed for 15 short- and long-chained PFAS using liquid chromatography triple quadrupole linear ion trap mass spectrometry. Total cholesterol, high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C) and triglyceride blood concentrations were measured at three test visits during pregnancy and at delivery. Physical activity was measured with a wrist-worn activity tracker 24/7 from inclusion before gestational age week 15 + 0 and throughout pregnancy.</p><p><strong>Results: </strong>In serum samples we detected the following PFAS: PFOS, PFOA, PFHxS, PFNA, PFDA, and PFUnDA. The maternal median concentrations at baseline were: PFOS: 4.09 ng/mL, PFOA: 0.81 ng/mL, PFHxS: 0.29 ng/mL, PFNA: 0.42 ng/mL, PFDA: 0.25 ng/mL, and PFUnDA: 0.19 ng/mL. Partner serum PFAS concentrations were 3-145% higher than maternal concentration (except for PFUnDA). PFAS concentrations correlated within couples. All PFAS decreased significantly during pregnancy (PFOS -23.1 percent 95%-CI [-31.9;-13.2] from baseline to delivery). All PFAS concentrations were associated with increased HDL-C concentrations. No associations between physical activity and maternal PFAS concentrations were found.</p><p><strong>Conclusions: </strong>Overall, serum PFAS concentrations decreased during pregnancy. PFAS concentrations within households were strongly correlated. PFAS and HDL-C concentrations were positively associated. We found no associations between physical activity and serum PFAS concentrations.</p><p><strong>Trial registration: </strong>The study was registered at ClinicalTrials.gov; NCT03679130; 20/09/2018.</p>","PeriodicalId":11686,"journal":{"name":"Environmental Health","volume":"24 1","pages":"16"},"PeriodicalIF":5.3,"publicationDate":"2025-04-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11963616/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143771521","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Maternal urinary concentrations of bisphenol A during pregnancy and birth size in children from the Odense Child Cohort.","authors":"Astrid L Beck, Elvira V Bräuner, Cecilie S Uldbjerg, Youn-Hee Lim, Henriette Boye, Hanne Frederiksen, Anna-Maria Andersson, Tina Kold Jensen","doi":"10.1186/s12940-025-01169-4","DOIUrl":"10.1186/s12940-025-01169-4","url":null,"abstract":"<p><strong>Background: </strong>Bisphenol A (BPA) is widely used in the manufacturing of plastics. BPA can pass the placental barrier and influence fetal development. Due to its estrogenic and anti-androgenic properties, BPA may contribute sex-specific differences in developmental effects. We examined associations between maternal urinary concentrations of BPA and birth size.</p><p><strong>Methods: </strong>In this cohort study of 832 mother-child pairs from the Odense Child Cohort, pregnant women provided spot urine samples at gestational week 28, which were analyzed for BPA by isotope diluted LC-MS/MS. Osmolality adjusted urinary BPA concentrations were categorized into quartiles. Mother-child characteristics were obtained from hospital records and questionnaires. Linear regression analyses examining the association between BPA concentrations and offspring birth size (weight, length, head, and abdominal circumference) were performed for the full cohort and stratified by offspring sex.</p><p><strong>Results: </strong>BPA was detected above the limit of detection in 85% of the urine samples with a median concentration of 1.33 ng/ml. In the full cohort, birth weight decreased significantly across increasing quartiles of maternal urinary BPA concentration, with the exception of the third quartile, which showed no significant association. In sex-stratified analyses, statistically significant decreases in birth weight were observed among male offspring in the highest quartile of maternal urinary BPA concentrations (β: -115 g, 95% CI: - 225, -4, p = 0.04) compared to male offspring of the lowest quartile and a possible dose-response association was suggested (p-trend = 0.06). No statistically significant associations were observed for birth weight amongst female offspring.</p><p><strong>Conclusions: </strong>Our findings suggest a negative association between maternal urinary BPA exposure and birth weight, driven by a lower birth weight in male offspring. Further research is required to explore the underlying mechanisms of BPA's possible sex-specific associations.</p>","PeriodicalId":11686,"journal":{"name":"Environmental Health","volume":"24 1","pages":"15"},"PeriodicalIF":5.3,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11960018/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143763171","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Maternal metabolomics linking prenatal exposure to fine particulate matter and birth weight: a cross-sectional analysis of the MADRES cohort.","authors":"Wu Chen, Chenyu Qiu, Jiayuan Hao, Jiawen Liao, Fred Lurmann, Nathan Pavlovic, Rima Habre, Dean P Jones, Theresa M Bastain, Carrie V Breton, Zhanghua Chen","doi":"10.1186/s12940-025-01162-x","DOIUrl":"10.1186/s12940-025-01162-x","url":null,"abstract":"<p><strong>Background: </strong>Prenatal exposure to air pollution has been associated with an increased risk of low birth weight. Disrupted metabolism may serve as an underlying mechanism, but the specific metabolic pathways involved remain unclear.</p><p><strong>Methods: </strong>In the Maternal and Developmental Risks from Environmental and Social Stressors (MADRES) study, 382 third-trimester maternal serum samples were analyzed for untargeted metabolomics using liquid chromatography with Fourier transform high-resolution mass spectrometry. Ambient concentrations of fine particulate matter (PM_2.5), particulate matter ≤ 10 μm in diameter (PM₁₀), nitrogen dioxide (NO₂), and ozone (O₃) were estimated using inverse-distance-squared weighted spatial interpolation based on daily residential histories. Birth weight was retrieved from medical records. Linear regression identified metabolomic features associated with air pollution exposure or birth weight, followed by Mummichog pathway enrichment and mediation analyses for the selected features.</p><p><strong>Results: </strong>Second-trimester PM_2.5 exposure was associated with lower birth weight. Fourteen metabolic pathways were significantly associated with second-trimester PM_2.5 exposure, with C21-steroid hormone biosynthesis and metabolism showing the most significant association. Sixteen metabolic pathways were significantly associated with birth weight, with vitamin A (retinol) metabolism being the most significantly enriched pathway. Seven pathways were associated with both PM_2.5 exposure and birth weight, including C21-steroid hormone biosynthesis and metabolism, bile acid biosynthesis, tyrosine metabolism, ascorbate (vitamin C) and aldarate metabolism, vitamin D3 (cholecalciferol) metabolism, vitamin A (retinol) metabolism, and pyrimidine metabolism. Overweight or obese women exhibited more metabolomic features and metabolic pathways associated with PM_2.5 exposure compared to underweight or normal-weight women. No associations were observed between PM₁₀, NO₂, or O₃ and birth weight.</p><p><strong>Conclusions: </strong>Maternal metabolic pathways involving steroid metabolism, oxidative stress and inflammation, vitamin metabolism, and DNA damage may link prenatal PM_2.5 exposure to lower birth weight, with overweight or obese women potentially more susceptible to these metabolic disruptions.</p>","PeriodicalId":11686,"journal":{"name":"Environmental Health","volume":"24 1","pages":"14"},"PeriodicalIF":5.3,"publicationDate":"2025-03-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11954335/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143742660","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}