Environmental Health最新文献

{"title":"Temporal and Spatial Effects of Extreme Drought Events on Human Epidemics over Ancient China in 1784-1787 CE.","authors":"Xiaoyi Hang, Zhaobin Sun, Juan He, Jingyi Xin, Shuwen Zhang, Yuxin Zhao, Zhen Tan, Ling Han, Yu Hao","doi":"10.1186/s12940-025-01163-w","DOIUrl":"10.1186/s12940-025-01163-w","url":null,"abstract":"<p><p>Extreme drought events can impact human health, notably triggering epidemics that impose significant global health and economic burdens. Understanding these effects and developing response strategies is crucial. However, there is limited epidemiological evidence on how climate change influenced ancient epidemics before large-scale urbanization and frequent population movements. In this study, we utilized the Reconstructed East Asian Climate Historical Encoded Series (REACHES) climate database and the self-constructed ancient Chinese epidemics database to examine extreme drought events in ancient China from 1784-1787 CE. We analyzed factors like grain prices, population density, and socioeconomic conditions to explore the temporal and spatial mechanism and influence the degree of extreme drought events on epidemics outbreaks. The results show that there is a clear positive link between drought and the spread of epidemics, with a notable one-year lag effect of drought. Drought impacts epidemics directly and indirectly through locust plague, famine, crop failure, and social turmoil, with famine being the most crucial factor. Official disaster management can mitigate epidemics. This study intuitively shows the relationship between extreme drought events and epidemics in ancient China and offering insights into the climate change-epidemic relationship. Placing the conclusions of this paper in a broader context has global implications, providing historical experience for polycrisis and modern challenges.</p>","PeriodicalId":11686,"journal":{"name":"Environmental Health","volume":"24 1","pages":"8"},"PeriodicalIF":5.3,"publicationDate":"2025-03-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11895321/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143603804","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Perinatal exposure to ambient fine particle air pollution and risk of childhood ewing sarcoma in a population-based case-control study in California (1988-2015).","authors":"Cassandra J Clark, Rong Wang, Joseph L Wiemels, Catherine Metayer, Nicole C Deziel, Xiaomei Ma","doi":"10.1186/s12940-025-01159-6","DOIUrl":"10.1186/s12940-025-01159-6","url":null,"abstract":"<p><strong>Background: </strong>Incidence of childhood Ewing sarcoma, a rare cancer affecting bones and soft tissues, is increasing. Environmental exposures during the perinatal period, like air pollution, may play a role. We examined exposure to perinatal ambient fine particulate matter (PM_2.5) and childhood Ewing sarcoma risk in a case-control linkage study nested within a California birth cohort.</p><p><strong>Methods: </strong>The study included 388 children born in California (1982-2015) and diagnosed with Ewing sarcoma at age 0-19 years (1988-2015), and 19,341 California-born cancer-free controls frequency-matched to cases on birth year (50:1 ratio). Ambient PM_2.5 concentrations at the maternal residence were averaged separately over two time periods, gestation and the first year after birth, using a validated ensemble-based model (categorized as quartiles). We estimated odds ratios (ORs) and 95% confidence intervals (CIs) for the association between perinatal PM_2.5 exposure and Ewing sarcoma risk, adjusting for sex, birth year, race, ethnicity, birth weight, and maternal education and stratifying by Hispanic ethnicity to assess potential disparities in PM_2.5-related cancer risk.</p><p><strong>Results: </strong>In the overall population, perinatal ambient PM_2.5 exposure was not associated with Ewing sarcoma risk when considering exposure during gestation or the year after birth. Among Hispanic children, who experienced greater air pollution exposure compared to non-Hispanic children, higher PM_2.5 levels during gestation yielded elevated odds of Ewing sarcoma compared to the first quartile (Q2 OR [95% CI] = 1.53 [0.94-2.51]; Q3 = 1.56 [0.95-2.56]; Q4 = 1.39 [0.79-2.47]). Hispanic children also experienced elevated risk in relation to exposure during the year after birth.</p><p><strong>Conclusion: </strong>Our results provide new suggestive evidence that ambient PM_2.5 may contribute to Ewing sarcoma risk, although these findings were not statistically significant and were specific to Hispanic children. These findings require replication and underscore the need to further evaluate the potential role of ethnicity in the PM_2.5-cancer relationship with genetic ancestry measures and through the lens of environmental justice.</p>","PeriodicalId":11686,"journal":{"name":"Environmental Health","volume":"24 1","pages":"6"},"PeriodicalIF":5.3,"publicationDate":"2025-03-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11887085/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143585071","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"PM_2.5 constituent exposures and maternal circulatory homocysteine in early pregnancy.","authors":"Xuesong Li, Mingyue Ran, Mengyuan Wang, Ao Liu, Bin Qiao, Bin Han, Jianmei Wang, Zhipeng Bai, Yujuan Zhang","doi":"10.1186/s12940-025-01160-z","DOIUrl":"10.1186/s12940-025-01160-z","url":null,"abstract":"<p><strong>Background: </strong>Elevated homocysteine (Hcy) is a pathogenic mechanism of adverse pregnancy outcomes and PM_2.5-induced cardiovascular diseases. We investigated the associations of fine particulate matter (PM_2.5) and chemical constituent exposures with maternal circulatory Hcy in early pregnancy.</p><p><strong>Methods: </strong>Serum Hcy and 5-methyltetrahydrofolate in 324 women with pregnancy (162 normal early pregnancy [NEP] and 162 early pregnancy loss [EPL]) were measured by ultra-performance liquid chromatography-tandem triple quadrupole mass spectrometry. Daily exposures to PM_2.5 and constituents (black carbon [BC], organic matter, nitrate, ammonium, and sulfate) were accessed using data of Tracking Air Pollution in China platform. Nonlinear and linear associations of average pollutant exposures during the post-conception period with serum Hcy were estimated using generalized additive models and multivariable linear regression models, respectively. Weekly cumulative and distributed lag associations between pollutant exposures within three months before serum collection and Hcy were analyzed by distributed lag nonlinear models combined with multivariable linear regression models. Sensitivity analyses were conducted using constituent residuals instead of constituent concentrations.</p><p><strong>Results: </strong>Three-month PM_2.5 and the five constituent exposures were associated with elevated serum Hcy in all participants, EPL group, and NEP group, with 3-12 weeks before serum collection being the susceptible exposure time windows. Pollutants-related Hcy were generally higher in EPL group than in NEP group. Higher post-conception PM_2.5, BC, and sulfate exposures increased serum Hcy in lower but not in higher 5-methyltetrahydrofolate subgroup. Sulfate was the highest risk constituent with residual-related increased Hcy. BC residuals of both post-conception and three-month periods increased Hcy in EPL group but not in NEP group.</p><p><strong>Conclusions: </strong>Maternal circulatory Hcy in early pregnancy increased with PM_2.5 and constituent exposures, with sulfate being the highest risk constituent. BC-related increased Hcy may induce EPL.</p><p><strong>Trial registration: </strong>The study protocol was registered for clinical trials (ChiCTR1900028619) on December 29, 2019.</p>","PeriodicalId":11686,"journal":{"name":"Environmental Health","volume":"24 1","pages":"7"},"PeriodicalIF":5.3,"publicationDate":"2025-03-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11887181/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143585133","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impacts of COVID-19 lockdown on PM_2.5-bound polycyclic aromatic hydrocarbons in Hohhot, Northern China: characteristics, sources, and source-specific health risks.","authors":"Kailin Ji, Bing Sun, Haijun Zhou, Wenjing Sun, Xiaotao Fu, Ying Sun, Huifang Ren, Yangchao Lv, Xi Chun, Zhiqiang Wan","doi":"10.1186/s12940-025-01161-y","DOIUrl":"10.1186/s12940-025-01161-y","url":null,"abstract":"<p><p>Quantifying the impacts of reduction strategies on PM_2.5-bound polycyclic aromatic hydrocarbons (PAHs) is essential for reducing the health risks of PM_2.5. The COVID-19 lockdown provided an opportunity to reveal the quantitative relationship between lockdown measures and the health risks of PAHs. In this study, the characteristics, sources, and health risks of PAHs were investigated during the COVID-19 lockdown in Hohhot. The source-specific health risks of PAHs were assessed using a combination of incremental lifetime cancer risk models (ILCR) and positive matrix factorization (PMF). Compared with the pre-LD period (pre-LD, 87.41 ± 5.98 ng·m^-3), the total concentration of ∑PAHs during the lockdown period (LD, 32.52 ± 2.31 ng·m^-3) decreased by 62.8% in Hohhot. Coal combustion (51.5%), gasoline emissions (21.9%), diesel emissions (12.9%), industrial emissions (9.3%), and biomass burning (4.7%) were the predominant sources of PAHs in Hohhot. Except for male children, the ILCR of all groups exceeded the threshold for high health risks (1 × 10^- 4). Dermal contact is the predominant exposure pathway for carcinogenic risk. Compared with the pre-LD period, the ILCR values decreased by 62.5-62.7% during the LD period. The PMF-ILCR results indicated that industrial emissions (29.1%), coal combustion (28.4%), and diesel emissions (18.5%) were the main sources of ∑ILCR. A Monte Carlo simulation revealed that the cumulative carcinogenic risks at the 95th percentile of the six groups were 1.5-6.3 times the threshold of high health risk (1 × 10^- 4). These results emphasize that regulating industrial emissions and coal combustion is effective in reducing carcinogenic risks in industrial cities with large coal consumption.</p>","PeriodicalId":11686,"journal":{"name":"Environmental Health","volume":"24 1","pages":"5"},"PeriodicalIF":5.3,"publicationDate":"2025-02-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11863873/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143515081","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Short-term attributable risk and economic burden of hospital admissions for anxiety disorders due to air pollution: a multicity time-stratified case-crossover study.","authors":"Peng Fu, Wanyanhan Jiang, Xinyi Tan, Yang Shu, Lian Yang","doi":"10.1186/s12940-025-01157-8","DOIUrl":"10.1186/s12940-025-01157-8","url":null,"abstract":"<p><strong>Background: </strong>Anxiety disorders are a leading cause of severe quality of life impairment and are among the most common mental disorders globally. However, few studies have investigated the association between exposure to high levels of air pollution and an increased risk of developing anxiety disorders. This study aimed to investigate the relationship between air pollutants and hospitalisation for anxiety disorders and the associated economic burden of these hospitalisations in Sichuan, China.</p><p><strong>Methods: </strong>We collected 7,282 records of anxiety disorder hospitalisation from medical institutions across nine cities between January 1, 2017, and December 31, 2018. Concurrent meteorological and air pollution data, including temperature, humidity, PM_2.5, PM₁₀, SO₂, and CO, were obtained from 183 monitoring stations in Sichuan Province. After controlling for long-term trends, day of the week, and meteorological factors, we employed a time-stratified case-crossover design based on conditional logistic regression to assess the association between concentrations of the four pollutants (PM_2.5, PM₁₀, SO₂, and CO) and hospital admissions for anxiety disorders, with stratified analysis by age, sex, and season. The cost of hospitalisation was evaluated using the cost-of-illness method.</p><p><strong>Results: </strong>The finding indicated a positive correlation between short-term exposure to air pollutants and hospitalization rates of anxiety disorders. The effect of each 10 µg/m³ increase in airborne particulate matter (PM) and SO₂ on hospital admissions for people with anxiety disorders peaked with a lag of 5 days, and each 1 mg/m³ increase in CO had the greatest effect on the 0-7 day moving average lag, with OR values of PM_2.5:1.002 (95% CI: 1.001,1.004), PM₁₀:1.001 (95% CI: 1.000,1.002), SO₂:1.034 (95% CI: 1.020,1.047), and CO: 1.614 (95% CI: 1.247, 2.089). Air pollution increases the chances of anxiety disorders during the cold season. Furthermore, the elderly are particularly susceptible to these pollutants, which may contribute to an increased hospitalization rates of anxiety disorders (P < 0.05). The total economic cost of hospitalisation for anxiety disorders due to particulate matter pollution was ¥ 966,319 during the study period.</p><p><strong>Conclusion: </strong>Short-term exposure to PM_2.5, PM₁₀, SO_2, and CO may increase the risk of hospital admissions for anxiety disorders and impose significant financial burdens.</p>","PeriodicalId":11686,"journal":{"name":"Environmental Health","volume":"24 1","pages":"4"},"PeriodicalIF":5.3,"publicationDate":"2025-02-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11846161/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143476392","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association between annual concentration of air pollutants and incidence of metabolic syndrome among Korean adults: Korean Genome and Epidemiology Study (KoGES).","authors":"Hanuel Shin, Minkyo Song, Sanghyuk Bae","doi":"10.1186/s12940-025-01158-7","DOIUrl":"10.1186/s12940-025-01158-7","url":null,"abstract":"<p><strong>Background: </strong>Air pollution is a global public health concern and incidence rates of metabolic syndrome (MetS) are increasing. To evaluate the effect of long-term air pollution exposure, we examined the association between long-term exposure to ambient air pollution and the incidences of MetS among Korean adults.</p><p><strong>Methods: </strong>We used data from the Korean Genome and Epidemiology Study's Cardiovascular Disease Association Study, a population-based cohort consisting of community-dwelling Korean adults between 2005 and 2011, who were followed up with until 2016 (n = 7,428). Air pollution exposure was estimated using the Congestion Mitigation and Air Quality model based on the participants' addresses. The participants had a physical examination at every visit during follow-up, and MetS was defined based on the National Institute of Health's National Cholesterol Education Program-Adult Treatment Panel III. We used Cox proportional hazard model to analyze the association between long-term air pollution exposure and incidences of MetS per interquartile range (IQR) increment of the annual concentration after adjusting for potential confounders using single and two-pollutant analysis.</p><p><strong>Results: </strong>The hazard ratios (HR) of MetS per IQR increment in PM_2.5, SO₂, NO₂, and CO were 1.19 (95% CI: 1.12-1.27), 1.57 (95% CI: 1.47-1.68), 1.11 (95% CI: 1.03-1.20), and 1.63 (95% CI: 1.48-1.78), respectively. The incidences of MetS components, which are high blood pressure, elevated fasting glucose, abdominal obesity, high fasting triglyceride (TG), and low fasting high-density lipoprotein (HDL-C), were significantly associated with an IQR increment especially in SO₂ and CO. In subgroup analysis, males had higher risk of MetS than females. The HR was the highest in the 60-69 year old age group for all pollutants.</p><p><strong>Conclusion: </strong>In the present study, we found that long-term ambient air pollution exposure increased the incidences of MetS and its components among Korean adults, especially in males and the elderly population.</p>","PeriodicalId":11686,"journal":{"name":"Environmental Health","volume":"24 1","pages":"3"},"PeriodicalIF":5.3,"publicationDate":"2025-02-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11818349/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143398681","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Combined effects of global DNA methylation, blood lead and total urinary arsenic levels on developmental delay in preschool children.","authors":"Yuu-Hueih Hsu, Chih-Yin Wu, Hui-Ling Lee, Ru-Lan Hsieh, Ya-Li Huang, Horng-Sheng Shiue, Ying-Chin Lin, Mei-Chieh Chen, Yu-Mei Hsueh","doi":"10.1186/s12940-024-01151-6","DOIUrl":"10.1186/s12940-024-01151-6","url":null,"abstract":"<p><p>DNA methylation is a critical step in brain development, 5-Methyl-2'-deoxycytidine (5mdC) is one of the global DNA methylation markers. Arsenic and lead exposures have been associated with neurotoxicity, which may be linked to epigenetic changes. Our research sought to investigate the correlation between 5mdC and developmental delay (DD) among preschoolers. Additionally, we assessed whether 5mdC modified the impacts of blood lead and total urinary arsenic levels on DD. We analyzed the concentrations of 5mdC, blood cadmium and lead, and total urinary arsenic in 174 children with DD and 88 healthy children. Global DNA methylation levels are expressed as the ratio 5mdC/2'-dexyguanosine (dG), called 5mdC (%). In our findings, elevated levels of blood lead and total urinary arsenic were significantly associated with DD risk among preschoolers. Furthermore, high 5mdC (%) was related with reduced risk of DD, with an odds ratio (OR) and 95% confidence interval (CI) of 0.14 (0.06 - 0.32). A notable multiplicative interaction was observed between low 5mdC (%) and elevated blood lead levels to increase OR of DD, with OR and 95% CI was 9.51 (4.18 - 21.64). The findings provide evidence of the combined effects of reduced 5mdC (%) and high blood lead concentrations, increasing the OR of DD.</p>","PeriodicalId":11686,"journal":{"name":"Environmental Health","volume":"24 1","pages":"2"},"PeriodicalIF":5.3,"publicationDate":"2025-01-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11740333/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143002289","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Integrating human biomonitoring exposure data into a primary care morbidity database: a feasibility study.","authors":"Pieter Jansen, Elly Den Hond, Katleen De Brouwere, Endale Alemayehu Ali, Hamid Yimam Hassen, Ilona Gabaret, Gijs Van Pottelbergh","doi":"10.1186/s12940-024-01152-5","DOIUrl":"10.1186/s12940-024-01152-5","url":null,"abstract":"<p><strong>Background: </strong>The detection of a local per- and polyfluoroalkyl substances (PFAS) pollution hotspot in Zwijndrecht (Belgium) necessitated immediate action to address health concerns of the local community. Several human biomonitoring (HBM) studies were initiated, gathering cross-sectional exposure data from more than 10,000 participants. The linkage of these HBM data with primary care health registries might be a useful new tool in environmental health analysis.</p><p><strong>Aim: </strong>We assessed the feasibility of linking exposure data from HBM programs to health outcomes from the Intego registry, which collects data from general practitioners' electronic health records. This feasibility study uses exposure data from one of the completed PFAS HBM studies, which included 796 individuals. We describe the separate datasets, the process of integrating the HBM data into Intego, the analysis plan and the advantages and challenges of using this method.</p><p><strong>Results: </strong>We established the integration of HBM data into the Intego primary care morbidity database, adhering to stringent privacy regulations and quality standards to ensure result integrity. Because of the modest sample size used in this feasibility study, no conclusions about the impact of PFAS on health endpoints can be drawn. However, with PFAS data from more than 10,000 residents available soon, more robust studies will be possible with this new method.</p><p><strong>Interpretation: </strong>We introduce a novel approach for assessing the impact of environmental health hazards within primary care settings. The methods outlined here not only pave the way for larger-scale projects but also offer a promising avenue for long-term environmental health monitoring.</p>","PeriodicalId":11686,"journal":{"name":"Environmental Health","volume":"24 1","pages":"1"},"PeriodicalIF":5.3,"publicationDate":"2025-01-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142926532","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The association between different timeframes of air pollution exposure and COVID-19 incidence, morbidity and mortality in German counties in 2020.","authors":"Sophie Hermanns, Erika von Schneidemesser, Alexandre Caseiro, Susanne Koch","doi":"10.1186/s12940-024-01149-0","DOIUrl":"10.1186/s12940-024-01149-0","url":null,"abstract":"<p><strong>Background: </strong>Ambient air pollution is a known risk factor for several chronic health conditions, including pulmonary dysfunction. In recent years, studies have shown a positive association between exposure to air pollutants and the incidence, morbidity, and mortality of a COVID-19 infection, however the time period for which air pollution exposure is most relevant for the COVID-19 outcome is still not defined. The aim of this study was to analyze the difference in association when varying the time period of air pollution exposure considered on COVID-19 infection within the same cohort during the first wave of the pandemic in 2020.</p><p><strong>Methods: </strong>We conducted a cross-sectional study analyzing the association between long- (10- and 2-years) and short-term (28 days, 7 days, and 2 days) exposure to NO₂ and PM_2.5 on SARS-CoV-2 incidence, morbidity, and mortality at the level of county during the first outbreak of the pandemic in spring 2020. Health data were extracted from the German national public health institute (Robert-Koch-Institute) and from the German Interdisciplinary Association for Intensive Care and Emergency Medicine. Air pollution data were taken from the APExpose dataset (version 2.0). We used negative binomial models, including adjustment for risk factors (age, sex, days since first COVID-19 case, population density, socio-economic and health parameters).</p><p><strong>Results: </strong>We found that PM_2.5 and NO₂ exposure 28 days before COVID-19 infection had the highest association with infection, morbidity as well as mortality, as compared to long-term or short-term (2 or 7 days) air pollutant exposure. A 1 μg/m³ increase in PM_2.5 was associated with a 31.7% increase in incidence, a 20.6% need for ICU treatment, a 23.1% need for mechanical ventilation, and a 55.3% increase in mortality; an increase of 1 μg/m³ of NO₂ was associated with an increase for all outcomes by 25.2 - 29.4%.</p><p><strong>Conclusions: </strong>Our findings show a positive association between PM_2.5 and NO₂ exposure and the clinical course of a SARS-CoV2 infection, with the strongest association to 28 days of exposure to air pollution. This finding provides an indication as to the primary underlying pathophysiology, and can therefore help to improve the resilience of societies by implementing adequate measures to reduce the air pollutant impact on health outcomes.</p><p><strong>Trial registration: </strong>Not applicable.</p>","PeriodicalId":11686,"journal":{"name":"Environmental Health","volume":"23 1","pages":"112"},"PeriodicalIF":5.3,"publicationDate":"2024-12-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11670380/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142892959","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Maternal multivitamin supplementation mitigates the risk of fetal congenital heart disease associated with high indoor total volatile organic compounds exposure in east china: a case-control study.","authors":"Xuehua Ruan, Wenyuan Shang, Jieru Lu, Zhuoyan Li, Jing Yang, Jinping Cheng, Yurong Wu, Kun Sun, Jing Sun","doi":"10.1186/s12940-024-01150-7","DOIUrl":"10.1186/s12940-024-01150-7","url":null,"abstract":"<p><strong>Background: </strong>Congenital heart disease (CHD) is a common birth defect. Our previous studies suggest that indoor air pollution, especially total volatile organic compounds (TVOCs), may increase fetal CHD risk, whereas vitamin and folic acid (FA) supplements in early pregnancy might offer protection against CHD. However, limited research has explored whether FA or multivitamin supplementation can mitigate the effects of TVOCs exposure on CHD.</p><p><strong>Methods: </strong>We conducted a case-control study to investigate the association between maternal nutrient supplementation, household indoor air pollutant exposure during pregnancy, and CHD in offspring. Pregnant women with 22-30 gestational weeks were recruited from two hospitals in East China between January 2016 and March 2022. A comprehensive approach was used, incorporating questionnaires to collect nutrient supplement information, blood sample analysis to detect serum folate, vitamin B12, and homocysteine (HCY) concentrations, and field investigations to assess indoor benzene, toluene, xylene, formaldehyde, and TVOCs exposures. Logistic regression analysis was performed to identify CHD risk factors, and stratified analysis was used to evaluate the combined effects of nutrient supplementation and TVOCs on CHD.</p><p><strong>Results: </strong>The study included 53 cases and 77 controls. Logistic regression analysis identified high maternal serum HCY (> 6.125 µmol/L) and high household TVOCs exposure (> 0.0165 mg/m³) as risk factors for CHD in offspring, with adjusted odds ratios of 2.98 (95% CI: 1.31-6.36) and 9.23 (95% CI: 3.78-22.53), respectively. Regular multivitamin supplementation mitigated the risk of high TVOCs exposure on fetal CHD, while the adverse effect of high serum HCY-related CHD risk was attenuated in the group with regular FA supplementation.</p><p><strong>Conclusion: </strong>Exposure to high indoor TVOCs concentrations increases the risk of fetal CHD. Regular multivitamin supplementation may reduce the adverse effects of high TVOCs exposure on fetal CHD.</p>","PeriodicalId":11686,"journal":{"name":"Environmental Health","volume":"23 1","pages":"110"},"PeriodicalIF":5.3,"publicationDate":"2024-12-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11662493/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142871733","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}