Yan Tong, Miriam Nakalembe, Collins Mpamani, Carolyn Nakisige, Jane Namugga, Grace Banturaki, Philiph Tonui, Omenge Orang'o, Kapten Muthoka, Anthony Ngeresa, John Groopman, Sean Burke, Aaron Ermel, Beverly Musick, Patrick Loehrer, Darron R Brown
{"title":"在乌干达妇女中，较高的血浆AFB1浓度与HPV 16和HPV 18检测和持续风险增加有关。","authors":"Yan Tong, Miriam Nakalembe, Collins Mpamani, Carolyn Nakisige, Jane Namugga, Grace Banturaki, Philiph Tonui, Omenge Orang'o, Kapten Muthoka, Anthony Ngeresa, John Groopman, Sean Burke, Aaron Ermel, Beverly Musick, Patrick Loehrer, Darron R Brown","doi":"10.1186/s12940-025-01197-0","DOIUrl":null,"url":null,"abstract":"<p><strong>Introduction: </strong>Aflatoxins are environmental hazards; potent carcinogenic and immunosuppressive agents that contaminates corn and other crops. A high proportion of hepatocellular carcinoma cases are caused by exposure to dietary aflatoxins. Cervical cancer is common among Ugandan women; this malignancy is caused by persistent infection with oncogenic HPV types. An analysis was performed to examine associations between plasma aflatoxin B<sub>1</sub> (AFB<sub>1</sub>) detection and oncogenic HPV detection (HPV types 16, 18, 31, 33, 35, 39, 45, 51, 52, 56, 58, 59, 66, and 68) and persistence among Ugandan women.</p><p><strong>Methods: </strong>Ugandan women were enrolled in a prospective cohort study. Annual cervical swabs (Enrollment, Month 12 and Month 24) were tested for oncogenic HPV. Plasma AFB<sub>1</sub> concentration was measured (as AFB<sub>1</sub>-lysine conjugate, or AFB<sub>1</sub>-lys) at Enrollment and Month 12. Multivariable regression models were fitted to examine associations of plasma AFB<sub>1</sub>-lys concentrations and oncogenic HPV controlling for demographic and behavioral characteristics.</p><p><strong>Results: </strong>The analytical sample consisted of 114 women with a mean age of 33.2 years; 60 women were living with HIV; 59 were receiving antiretroviral therapy (ART) at enrollment. AFB<sub>1</sub>-lysine adducts (AFB<sub>1</sub>-lys) was detected in plasma from all 114 women. Multivariable regression models showed that plasma AFB<sub>1</sub>-lys concentration was associated with a higher risk of detection of HPV 16 (OR = 2.64, 95% CI = 1.42-4.90, p = 0.002) and HPV 18 (OR = 2.24, 95% CI = 1.27-3.96, p = 0.005), and persistence of HPV 16 (OR = 3.16, 95% CI = 1.59-6.26, p = 0.001) and HPV 18 (OR = 2.06, 95% CI = 1.09-3.90, p = 0.025), controlling for age, marital status, years of education, home ownership, distance to health care, number of lifetime sex partners, age of first sex, and HIV status.</p><p><strong>Conclusions: </strong>AFB<sub>1</sub> is an environmental hazard that is prevalent among Ugandan women. Higher plasma AFB<sub>1</sub>-lys concentration was associated with detection and persistence of HPV 16 and HPV 18; this association was independent of HIV status. As a result, these women may be at increased risk of cervical cancer. Further studies are needed to determine the mechanisms involved.</p>","PeriodicalId":11686,"journal":{"name":"Environmental Health","volume":"24 1","pages":"45"},"PeriodicalIF":5.3000,"publicationDate":"2025-07-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12235798/pdf/","citationCount":"0","resultStr":"{\"title\":\"Higher plasma AFB1 concentration is associated with increased risk of HPV 16 and HPV 18 detection and persistence among Ugandan women.\",\"authors\":\"Yan Tong, Miriam Nakalembe, Collins Mpamani, Carolyn Nakisige, Jane Namugga, Grace Banturaki, Philiph Tonui, Omenge Orang'o, Kapten Muthoka, Anthony Ngeresa, John Groopman, Sean Burke, Aaron Ermel, Beverly Musick, Patrick Loehrer, Darron R Brown\",\"doi\":\"10.1186/s12940-025-01197-0\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Introduction: </strong>Aflatoxins are environmental hazards; potent carcinogenic and immunosuppressive agents that contaminates corn and other crops. A high proportion of hepatocellular carcinoma cases are caused by exposure to dietary aflatoxins. Cervical cancer is common among Ugandan women; this malignancy is caused by persistent infection with oncogenic HPV types. An analysis was performed to examine associations between plasma aflatoxin B<sub>1</sub> (AFB<sub>1</sub>) detection and oncogenic HPV detection (HPV types 16, 18, 31, 33, 35, 39, 45, 51, 52, 56, 58, 59, 66, and 68) and persistence among Ugandan women.</p><p><strong>Methods: </strong>Ugandan women were enrolled in a prospective cohort study. Annual cervical swabs (Enrollment, Month 12 and Month 24) were tested for oncogenic HPV. Plasma AFB<sub>1</sub> concentration was measured (as AFB<sub>1</sub>-lysine conjugate, or AFB<sub>1</sub>-lys) at Enrollment and Month 12. Multivariable regression models were fitted to examine associations of plasma AFB<sub>1</sub>-lys concentrations and oncogenic HPV controlling for demographic and behavioral characteristics.</p><p><strong>Results: </strong>The analytical sample consisted of 114 women with a mean age of 33.2 years; 60 women were living with HIV; 59 were receiving antiretroviral therapy (ART) at enrollment. AFB<sub>1</sub>-lysine adducts (AFB<sub>1</sub>-lys) was detected in plasma from all 114 women. Multivariable regression models showed that plasma AFB<sub>1</sub>-lys concentration was associated with a higher risk of detection of HPV 16 (OR = 2.64, 95% CI = 1.42-4.90, p = 0.002) and HPV 18 (OR = 2.24, 95% CI = 1.27-3.96, p = 0.005), and persistence of HPV 16 (OR = 3.16, 95% CI = 1.59-6.26, p = 0.001) and HPV 18 (OR = 2.06, 95% CI = 1.09-3.90, p = 0.025), controlling for age, marital status, years of education, home ownership, distance to health care, number of lifetime sex partners, age of first sex, and HIV status.</p><p><strong>Conclusions: </strong>AFB<sub>1</sub> is an environmental hazard that is prevalent among Ugandan women. Higher plasma AFB<sub>1</sub>-lys concentration was associated with detection and persistence of HPV 16 and HPV 18; this association was independent of HIV status. As a result, these women may be at increased risk of cervical cancer. 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引用次数: 0
摘要
简介：黄曲霉毒素是环境危害；污染玉米和其他作物的强致癌物和免疫抑制剂。高比例的肝细胞癌病例是由暴露于饮食黄曲霉毒素引起的。宫颈癌在乌干达妇女中很常见；这种恶性肿瘤是由致癌型HPV持续感染引起的。分析了血浆黄曲霉毒素B1 （AFB1）检测与致癌HPV检测（HPV型16、18、31、33、35、39、45、51、52、56、58、59、66和68）和乌干达妇女持续性之间的关系。方法：乌干达妇女被纳入前瞻性队列研究。每年宫颈拭子（入组12个月和24个月）检测致瘤性HPV。在入组和第12个月测定血浆AFB1浓度（AFB1-赖氨酸偶联物，或AFB1-赖氨酸）。采用多变量回归模型检验血浆afb1 - lyys浓度与控制人口统计学和行为特征的致癌HPV之间的关系。结果：分析样本包括114名女性，平均年龄33.2岁；60名妇女感染艾滋病毒；59人在入组时接受抗逆转录病毒治疗（ART）。114名妇女血浆中均检测到afb1 -赖氨酸加合物（AFB1-lys）。多变量回归模型表明,等离子体AFB1-lys浓度与检测HPV 16的风险更高(OR = 2.64, 95% CI -4.90 = 1.42, p = 0.002)和人乳头状瘤病毒18 (OR = 2.24, 95% CI -3.96 = 1.27, p = 0.005),和持久性的HPV 16 (OR = 3.16, 95% CI -6.26 = 1.59, p = 0.001)和人乳头状瘤病毒18 (OR = 2.06, 95% CI -3.90 = 1.09, p = 0.025),控制了年龄,婚姻状况,多年的教育,拥有住房,距离医疗、终生性伴侣,第一次性行为的年龄和艾滋病毒状况。结论：AFB1是一种在乌干达妇女中普遍存在的环境危害。较高的血浆afb1 - lyys浓度与HPV 16和HPV 18的检测和持续有关；这种联系与艾滋病毒状况无关。因此，这些妇女患子宫颈癌的风险可能会增加。需要进一步的研究来确定所涉及的机制。
Higher plasma AFB1 concentration is associated with increased risk of HPV 16 and HPV 18 detection and persistence among Ugandan women.
Introduction: Aflatoxins are environmental hazards; potent carcinogenic and immunosuppressive agents that contaminates corn and other crops. A high proportion of hepatocellular carcinoma cases are caused by exposure to dietary aflatoxins. Cervical cancer is common among Ugandan women; this malignancy is caused by persistent infection with oncogenic HPV types. An analysis was performed to examine associations between plasma aflatoxin B1 (AFB1) detection and oncogenic HPV detection (HPV types 16, 18, 31, 33, 35, 39, 45, 51, 52, 56, 58, 59, 66, and 68) and persistence among Ugandan women.
Methods: Ugandan women were enrolled in a prospective cohort study. Annual cervical swabs (Enrollment, Month 12 and Month 24) were tested for oncogenic HPV. Plasma AFB1 concentration was measured (as AFB1-lysine conjugate, or AFB1-lys) at Enrollment and Month 12. Multivariable regression models were fitted to examine associations of plasma AFB1-lys concentrations and oncogenic HPV controlling for demographic and behavioral characteristics.
Results: The analytical sample consisted of 114 women with a mean age of 33.2 years; 60 women were living with HIV; 59 were receiving antiretroviral therapy (ART) at enrollment. AFB1-lysine adducts (AFB1-lys) was detected in plasma from all 114 women. Multivariable regression models showed that plasma AFB1-lys concentration was associated with a higher risk of detection of HPV 16 (OR = 2.64, 95% CI = 1.42-4.90, p = 0.002) and HPV 18 (OR = 2.24, 95% CI = 1.27-3.96, p = 0.005), and persistence of HPV 16 (OR = 3.16, 95% CI = 1.59-6.26, p = 0.001) and HPV 18 (OR = 2.06, 95% CI = 1.09-3.90, p = 0.025), controlling for age, marital status, years of education, home ownership, distance to health care, number of lifetime sex partners, age of first sex, and HIV status.
Conclusions: AFB1 is an environmental hazard that is prevalent among Ugandan women. Higher plasma AFB1-lys concentration was associated with detection and persistence of HPV 16 and HPV 18; this association was independent of HIV status. As a result, these women may be at increased risk of cervical cancer. Further studies are needed to determine the mechanisms involved.
期刊介绍：
Environmental Health publishes manuscripts on all aspects of environmental and occupational medicine and related studies in toxicology and epidemiology.
Environmental Health is aimed at scientists and practitioners in all areas of environmental science where human health and well-being are involved, either directly or indirectly. Environmental Health is a public health journal serving the public health community and scientists working on matters of public health interest and importance pertaining to the environment.
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