Environment International最新文献

{"title":"Retraction notice to \"High-throughput screening of ancient forest plant extracts shows cytotoxicity towards triple-negative breast cancer\" [Environ. Int. 181 (2023) 108279].","authors":"Yiyang Li, Nyuk Ling Ma, Huiling Chen, Jiateng Zhong, Dangquan Zhang, Wanxi Peng, Su Shiung Lam, Yafeng Yang, Xiaochen Yue, Lijun Yan, Ting Wang, Bjarne Styrishave, Tomasz Maciej Ciesielski, Christian Sonne","doi":"10.1016/j.envint.2026.110443","DOIUrl":"https://doi.org/10.1016/j.envint.2026.110443","url":null,"abstract":"","PeriodicalId":308,"journal":{"name":"Environment International","volume":" ","pages":"110443"},"PeriodicalIF":10.2,"publicationDate":"2026-09-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148885820","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Fish consumption guidelines during pregnancy: are they effective in minimising mercury exposure in Spain?","authors":"Lourdes Herraiz-Recuenco, Ana I Cañas-Portilla, Marta Esteban-López","doi":"10.1016/j.envint.2026.110489","DOIUrl":"https://doi.org/10.1016/j.envint.2026.110489","url":null,"abstract":"<p><p>Fish and seafood consumption provides essential nutrients for fetal and child development but is also the main source of human exposure to methylmercury, a neurotoxic substance of public health concern. To ensure safe consumption during pregnancy and early life, food safety authorities have issued recommendations; however, their integration into clinical guidelines and practice remains unclear. This study assessed whether fish consumption advice during pregnancy in Spain adequately addresses mercury exposure by integrating evidence from biomonitoring studies, guideline analysis, and healthcare professionals' practices. A scoping review identified studies measuring mercury biomarkers in pregnant women and children. In parallel, international, national, and regional guidelines in Spain were reviewed to evaluate the presence, accuracy, and clarity of recommendations. Additionally, a nationwide cross-sectional survey was conducted among healthcare professionals involved in maternal and childcare. The scoping review showed consistent evidence of mercury exposure in pregnant women and children, largely influenced by fish consumption patterns. Guideline analysis revealed substantial heterogeneity, frequent omissions of official recommendations, and the use of outdated or incomplete information. Survey results indicated limited awareness of official guidance among healthcare professionals and inconsistent communication of advice to pregnant women. Overall, despite the availability of scientific evidence and official recommendations, fish consumption advice during pregnancy in Spain is inadequately integrated into clinical guidelines and healthcare practice. Strengthening dissemination and implementation of clear, updated, and evidence-based recommendations is essential to support healthcare professionals and ensure safe fish consumption during pregnancy.</p>","PeriodicalId":308,"journal":{"name":"Environment International","volume":"215 ","pages":"110489"},"PeriodicalIF":10.2,"publicationDate":"2026-09-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148885839","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prenatal and early life phthalate exposure and early life stress: no interactions with adolescent internalizing symptoms.","authors":"Mariah DeSerisy, Gabriella Meltzer, Arin Balalian, Shabnaz Siddiq, Autumn M Clemons, Julie B Herbstman, Virginia A Rauh, Frederica P Perera, Amy E Margolis, Pam Factor-Litvak","doi":"10.1016/j.envint.2026.110500","DOIUrl":"https://doi.org/10.1016/j.envint.2026.110500","url":null,"abstract":"<p><p>Prenatal and early life exposure to phthalates has been increasingly implicated in adverse neurodevelopmental outcomes. However, associations between phthalate exposure in early life and later adolescent mental health remain understudied, particularly when also considering co-exposure to early life psychosocial stressors. We examined the independent and combined associations of prenatal and early life (ages three, five, and seven) phthalate exposure with adolescent internalizing symptoms in a longitudinal cohort of 563 Black and Latiné mother-child dyads living in a low-income urban neighborhood. We further explored whether early life stress modified these associations or predicted internalizing symptoms independently. Exposure to eleven common phthalates was assessed using urinary metabolites measured in the third trimester of pregnancy and in children ages three, five, and seven. Early life stress was operationalized by a composite measure of material hardship and maternal demoralization measured concurrently with phthalate exposure. Youth self-reported anxiety and depression symptoms were measured between ages 13-15 with the Revised Children's Manifest Anxiety Scale and Center for Epidemiological Studies Depression Inventory, respectively. Bayesian kernel machine regression assessed effects of the phthalate mixture on anxiety and depression symptoms. False discovery rate-corrected, pooled linear regressions tested individual phthalate effects, stratified by sex, and tested early life stress as an effect modifier. We did not detect significant associations between prenatal or postnatal phthalate exposure-either independently or jointly-and adolescent depression or anxiety; early life stress did not modify these associations or independently predict symptomology. However, uncertainty in effect estimates necessitates future research to clarify if these null effects hold in larger samples. If replicated, our findings suggest that there may be important, as yet unknown resilience factors protecting youth from long term effects of early phthalate exposure.</p>","PeriodicalId":308,"journal":{"name":"Environment International","volume":"215 ","pages":"110500"},"PeriodicalIF":10.2,"publicationDate":"2026-09-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148885889","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Long-term exposure to trihalomethanes in drinking water and risk of liver and kidney cancer: a population-based cohort study","authors":"Emilie Helte, Melle Säve-Söderbergh, Agneta Åkesson","doi":"10.1016/j.envint.2026.110501","DOIUrl":"https://doi.org/10.1016/j.envint.2026.110501","url":null,"abstract":"Chlorination of drinking water effectively prevents waterborne infections but also results in the formation of potentially carcinogenic disinfection by-products, including trihalomethanes (THMs). Experimental animal studies indicate that the liver and kidney are target organs for THM carcinogenicity, yet epidemiological evidence remains limited for these sites. In this study we assessed the association of long-term exposure to THMs in drinking water with incidence of liver and kidney cancer in two large Swedish population-based cohorts. We included 58,664 adults from the Swedish Infrastructure for Medical Population-Based Life-Course and Environmental Research (SIMPLER), who were supplied by public drinking water. Individual residential histories were linked to a national database of drinking-water monitoring results to estimate long-term exposure to total THMs. Incident liver and kidney cancer cases were ascertained through linkage to the Swedish Cancer Registry. Multivariable-adjusted Cox proportional hazards regression models were fitted to estimate adjusted hazard ratios (HRs) and 95% confidence intervals (CIs). Over 25 years of follow-up, 183 liver cancer cases and 347 kidney cancer cases were ascertained. Residential drinking water THM exposure was not associated with liver cancer. For kidney cancer, THM was dose-dependently associated with higher risk (p-trend = 0.047) among men with HR 1.54 (95% CI 1.00, 2.38) comparing ≥15 µg THM/L with no drinking water chlorination. No association was observed among women. Although based on a limited number of cases, these findings provide novel prospective cohort evidence on the potential association between long-term THM exposure and kidney cancer at exposure levels below current regulatory limits for drinking water. The observed association warrant confirmation in future independent studies.","PeriodicalId":308,"journal":{"name":"Environment International","volume":"46 1","pages":""},"PeriodicalIF":11.8,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148883953","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mercury exposure and potential hazards through vegetation intake to large herbivores along an elevational gradient in the Central Himalayas","authors":"Huihui Song,&nbsp;Yiming Hu,&nbsp;Ruiping Luo,&nbsp;Huina Lin,&nbsp;Zuxiu Yao,&nbsp;Yizhu Yan,&nbsp;Liuxuan Lv,&nbsp;Yaning Zhang,&nbsp;Wei Zhang,&nbsp;Wu Chen,&nbsp;Yanju Ma,&nbsp;Veerle L.B. Jaspers,&nbsp;Lihai Shang","doi":"10.1016/j.envint.2026.110460","DOIUrl":"10.1016/j.envint.2026.110460","url":null,"abstract":"<div><div>Vegetation in mountains offers specific habitats for endemic wildlife while serving as a sink for long-range transported pollutants such as mercury (Hg). Over half of the atmospheric Hg is absorbed by vegetation, making it a major pathway for Hg transfer into terrestrial ecosystems. As one of the world’s 22 biodiversity hotspots and situated between the major Hg emitters in Asia, the Himalayas host numerous endemic and endangered species, including large herbivores that play vital ecological roles. We investigated total Hg (THg) in vegetation across five vegetation zones along the longest elevational gradient (1800 <span><math><mrow><mo>∼</mo></mrow></math></span> 5400 m) in the Central Himalayas. Mean vegetation THg was 20.2 ± 10.7 ng g⁻¹ (6.0 <span><math><mrow><mo>∼</mo></mrow></math></span> 62.9 ng g⁻¹, 60 sampling sites). Overall, vegetation THg decreased significantly with elevation (<em>y = (−0.004 ± 0.001) x + (33.5 ± 4.8)</em>, <em>R</em> ² = 0.13, <em>p</em> = 0.005), with soil THg explaining the variation most. We found 6 herbivore species inhabiting evergreen broad-leaved forest and 10 species inhabiting subalpine coniferous forest, could be facing potential Hg exposure risk in those vegetation zones. When we combine this with captive daily intake estimation of vegetation, we identified endangered high-altitude species, such as Himalayan tahr (<em>Hemitragus jemlahicus</em>) and kiang (<em>Equus kiang</em>), which could be more at Hg exposure risk under climate change due to potential habitat shrinkage. Our findings highlight that, in addition to predators, large herbivores may also face elevated Hg exposure risk due to their substantial consumption of vegetation, which is important when evaluating the Minamata Convention’s effectiveness.</div></div>","PeriodicalId":308,"journal":{"name":"Environment International","volume":"215 ","pages":"Article 110460"},"PeriodicalIF":10.2,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148811715","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Health in nationally determined contributions: a policy analysis of 191 countries","authors":"Ana-Catarina Pinho-Gomes,&nbsp;Katherine C. Dibbon,&nbsp;Gabriela Cipriano-Flores,&nbsp;Rachel Hulme,&nbsp;Jessica Gong,&nbsp;Jane Hirst,&nbsp;Alice Witt,&nbsp;Kate Womersley,&nbsp;Celestine Donovan-Bradley,&nbsp;Edward Mullins","doi":"10.1016/j.envint.2026.110473","DOIUrl":"10.1016/j.envint.2026.110473","url":null,"abstract":"<div><h3>Background</h3><div>Nationally Determined Contributions (NDCs) describe the commitments made by each country to reduce its greenhouse gas emissions. Assessing how health is considered in NDCs is critical to understand how countries plan to protect their populations’ health from climate change.</div></div><div><h3>Methods</h3><div>This policy analysis investigated how health was considered by NDCs for 191 countries across seven domains: health co-benefits, health adaptation, health impacts, sustainable healthcare, health inequalities, women, and other. It included quantitative analysis, which summarised the score for each domain, and qualitative analysis using content analysis to identify common themes (i.e., recurring patterns/concepts).</div></div><div><h3>Results</h3><div>The mean of the total score was 4.7 (SD 3.5) points for the first submission, with median of 5 [range 0–12] points. For the second submission, the mean of the total score was 3.2 (SD 3.7) points, with median of 2 [range 0–12] points. The mean of the total score for the third submission was 7.3 (SD 3.2) points, with median of 9 [range 0–13] points. Latin American and Caribbean States achieved the highest scores. Content analysis identified important themes, such as the direct and indirect impacts of climate change on health, the need to adopt bold policies to protect the population with early warning systems and other health protection interventions, the need to build resilient health systems, the co-benefits of transitioning to renewable energy sources, the unequal impact of climate change, and the importance of gender equality and women’s vulnerability.</div></div><div><h3>Conclusions</h3><div>Although health is considered by the NDCs of most countries, this is often superficial and does not capture the entirety of the health impacts and co-benefits. There is a need to consider health across all domains of climate mitigation and adaptation to prevent climate change from widening health inequalities and to inform planning to mitigate negative impacts on population health. Full consideration of health impacts and co-benefits is likely to strengthen the moral and economic cases for nations to prioritise action on climate change and to prevent ideology-based minimisation of the need for action.</div></div>","PeriodicalId":308,"journal":{"name":"Environment International","volume":"215 ","pages":"Article 110473"},"PeriodicalIF":10.2,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148786527","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Source fingerprint-guided species-specific concentration mapping for targeted malodor source management in industrial park","authors":"Manyun Long,&nbsp;Xuejie Shen,&nbsp;Tianqi Feng,&nbsp;Zhan Zhang,&nbsp;Yusheng Qin,&nbsp;Xiangxian Li,&nbsp;Xin Han,&nbsp;Lichao Lu,&nbsp;Zhen Cao,&nbsp;Xue Li,&nbsp;Xiaoxiao Li,&nbsp;Yang Luo,&nbsp;Jingkun Jiang,&nbsp;Wenqing Liu,&nbsp;Zehui Li","doi":"10.1016/j.envint.2026.110470","DOIUrl":"10.1016/j.envint.2026.110470","url":null,"abstract":"<div><div>Malodorous compounds (MCs) feature ultra-low olfactory thresholds, episodic emissions and rapid dispersion, which complicate the analysis of their spatiotemporal behaviors and hinders real-time identification and spatial mapping of individual odorants in industrial park malodor management. Here, we developed a cost-effective sensor array network guided by source-specific emission fingerprints. The network, calibrated in situ using XGBoost models, achieved species-specific, real-time concentration mapping of multiple MCs across a 3 km² industrial park. A standardized protocol integrating olfactory screening and multi-platform instrumental analysis identified trimethylamine, ethanethiol, hydrogen sulfide and ammonia as the dominant MCs. Dedicated sensor arrays were then constructed based on these source-specific signatures and calibrated in situ against co‑located Fourier transform infrared (FTIR) measurements. A high-density monitoring network of 42 monitors equipped with sensor arrays was established, acquiring data at 10-minute intervals. Real-time concentration mapping based on the monitoring network directly linked MCs to their respective sources. Validated by independent mobile FTIR measurements, the network localized hotspots with &lt;150 m deviation. This source fingerprint-guided spatial monitoring network transforms odor management from a complaint-driven response to source-targeted precision monitoring, offering a paradigm for industrial environmental supervision.</div></div>","PeriodicalId":308,"journal":{"name":"Environment International","volume":"215 ","pages":"Article 110470"},"PeriodicalIF":10.2,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148849625","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Green space is associated with better directed attention and higher crystallized intelligence in middle childhood: Evidence from the ABCD study","authors":"Carina H. Fowler, Joan L. Luby, Theresa M. Bastain, Carrie V. Breton, Deanna M. Barch","doi":"10.1016/j.envint.2026.110502","DOIUrl":"https://doi.org/10.1016/j.envint.2026.110502","url":null,"abstract":"In the United States, rising attention problems and falling academic achievement in childhood are a public health concern given the importance of childhood directed attention (e.g., effortful, top-down driven attention) and achievement in predicting long-term outcomes. Guided by Attention Restoration Theory (ART), several papers have tested the hypothesis that greater green space exposure may support improved directed attention and achievement in children, with mixed results. To help clarify the role of green space in supporting childhood directed attention and achievement, we tested this hypothesis in the large, diverse Adolescent Brain Cognitive Development (ABCD) Study. American children (<ce:italic>N</ce:italic> = 11,868, <ce:italic>M</ce:italic><ce:inf loc=\"post\">age</ce:inf> = 9.96 years; 52.16% assigned female) completed a performance-based assessment of their directed attention and crystallized intelligence (a proxy measure of achievement) and had their green space exposure assessed as the average of the proportion of tree canopy and the proportion of park cover in their census tracts. Linear mixed-effects models with random intercepts for site and family revealed that green space was positively associated with both directed attention (<ce:italic>β =</ce:italic> 0.76, <ce:italic>p &lt; 0</ce:italic>.001) and crystallized intelligence (<ce:italic>β =</ce:italic> 0.83, <ce:italic>p &lt; 0</ce:italic>.001), adjusting for area deprivation index (ADI), assigned sex, ADHD diagnosis, stimulant use, sleep problems, perceived safety, media use, prenatal tobacco exposure, air pollution (PM<ce:inf loc=\"post\">2.5</ce:inf>), and physical activity. Additionally, PM<ce:inf loc=\"post\">2.5</ce:inf> mediated the association between green space and directed attention (indirect effect: <ce:italic>β =</ce:italic> 0.06, 95% CI = [0.02, 0.11]) and between green space and crystallized intelligence (<ce:italic>β</ce:italic> = 0.06, 95% CI = [0.01, 0.11]). These cross-sectional results indicate that green space is positively associated with childhood attention and crystallized intelligence and that these associations may be explained by improved air quality.","PeriodicalId":308,"journal":{"name":"Environment International","volume":"23 1","pages":""},"PeriodicalIF":11.8,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148883920","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sparse group lasso weighted quantile sum regression for analyzing chemical mixture effects: bidirectional effect estimation with two-stage group-level evaluation","authors":"Takayuki Kawashima,&nbsp;Kohki Takaguchi,&nbsp;Norimichi Suzuki,&nbsp;Akifumi Eguchi","doi":"10.1016/j.envint.2026.110480","DOIUrl":"10.1016/j.envint.2026.110480","url":null,"abstract":"<div><div>Chemical mixture studies often require methods that account for predefined exposure groups, prioritize active components within correlated groups, and allow positive and negative associations in the same analysis. We developed Sparse Group Lasso Weighted Quantile Sum regression (SGL-WQS), an index-based method that combines WQS regression with sparse group lasso regularization. SGL-WQS estimates group- and direction-specific indices in training data and evaluates downstream associations in held-out data as exploratory conditional summaries. Evaluation included a large-scale simulation; 30-seed studies of correlation, component prioritization, sample size, dimensionality, outcome family, group-size imbalance, and signal heterogeneity; repeated split-stability analyses; benchmark comparisons; and a survey-aware urinary VOC demonstration. In the large-scale simulation, estimates were consistent with the expected positive PCB, mixed-direction metal, and null PFAS patterns. In matched Gaussian simulations, direction assignment improved with sample size and remained stable from p = 50 to 200 under baseline signals, although component attribution and validation-stage conditional informativeness declined with dimensionality. Within-scenario group-size imbalance did not produce a consistent loss of direction accuracy; weak and dense signals had a larger effect across methods. In exactly paired binary/Gaussian global-null analyses, conditional p &lt; 0.05 proportions did not exceed 0.05 (0.025–0.045). In the survey-aware VOC demonstration, SGL-WQS provided group- and direction-specific summaries across four metabolite groups using NHANES subsample weights in the downstream refit. SGL-WQS may therefore be useful for exploratory, group-aware bidirectional prioritization rather than estimation of a single overall mixture effect or formal selective inference.</div></div>","PeriodicalId":308,"journal":{"name":"Environment International","volume":"215 ","pages":"Article 110480"},"PeriodicalIF":10.2,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148838699","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Diquat exposure disrupts ferroportin–dependent iron homeostasis and drives ferroptosis–associated white matter injury","authors":"Pengyu Bai, Xueshan Cao, Songhang Wang, Qi Cao, Tianyuan Li, Shanshan Li, Yubo Liu, Bailin Wu, Bo Song","doi":"10.1016/j.envint.2026.110496","DOIUrl":"https://doi.org/10.1016/j.envint.2026.110496","url":null,"abstract":"Diquat (DQ) is one of the most widely used bipyridyl herbicides and has been identified as a potential neurotoxin; however, its primary central nervous system (CNS) targets and the underlying mechanisms remain unclear. In cases of acute human DQ poisoning, subcortical white matter lesions have been reported to emerge approximately two weeks after exposure, with demyelination representing the predominant pathological finding. We used an acute oral DQ exposure rat model that mimics human DQ poisoning. Magnetic resonance imaging (MRI) revealed prominent white matter abnormalities in the corpus callosum, while histological analyses confirmed demyelination, impaired myelin integrity, reduced myelin basic protein (MBP) and myelin oligodendrocyte glycoprotein (MOG) expression, and marked mitochondrial ultrastructural damage. RNA sequencing indicated significant enrichment of ferroptosis-associated pathways. DQ induced sustained intracellular reactive oxygen species (ROS) accumulation and reduced nuclear factor erythroid 2-related factor 2 (Nrf2) expression. DQ exposure also reduced ferroportin (FPN) expression, accompanied by intracellular Fe<ce:sup loc=\"post\">2</ce:sup>⁺ accumulation, enhanced lipid peroxidation, and ferroptotic cell death. <ce:italic>In vivo</ce:italic>, ferrostatin-1 pretreatment significantly attenuated DQ-induced demyelination. <ce:italic>In vitro</ce:italic>, N-acetylcysteine (NAC) partially restored Nrf2 expression and attenuated DQ-induced lipid peroxidation, whereas FPN overexpression reduced intracellular Fe<ce:sup loc=\"post\">2</ce:sup>⁺ accumulation and lipid peroxidation. Collectively, these findings suggest that DQ disrupts redox balance and iron homeostasis in association with reduced Nrf2 signaling and FPN expression. Targeting FPN-mediated iron homeostasis warrants further investigation as a potential strategy for limiting DQ-induced neurotoxicity.","PeriodicalId":308,"journal":{"name":"Environment International","volume":"9 1","pages":""},"PeriodicalIF":11.8,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148883954","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}