Environment International最新文献

{"title":"Sexual behavior in male mice is impaired by an obesogenic-diabetogenic diet and worsened by exposure to a relevant environmental mixture of phthalates","authors":"Mahiddine Lina, Parmentier Caroline, Touarssi Kaoutar, Grange-Messent Valérie, Mhaouty-Kodja Sakina, Hardin-Pouzet Hélène","doi":"10.1016/j.envint.2025.109858","DOIUrl":"https://doi.org/10.1016/j.envint.2025.109858","url":null,"abstract":"The decrease in male fertility observed since the beginning of the 20th century in Western countries could be linked to changes in diets and exposure to molecules from industry, such as endocrine disruptors and, among them, phthalates. The combined effects of a high fat/high fructose diet (HFHF) and exposure to an environmental mixture of phthalates (mix) were evaluated on male murine sexual behavior. Four groups of adult male C57Bl/6J mice were exposed to a control diet (CD), a control diet coupled with the mix (CDmix), an HFHF diet, and an HFHF diet coupled with the mix (HFHFmix). Both HFHF diets induced metabolic alterations but only the HFHFmix diet altered the efficiency of sexual behavior, with a dramatic decrease in the number of animals reaching ejaculation and a subsequent increase in mating latency. This was associated with a decrease in testicular, seminal glands and Tyson glands weights and a loss in discrimination toward female counterparts in an olfactory preference test. No effects were recorded on locomotion activity. In the HFHFmix group, the protein amounts of synaptophysin, dopamine transporter (DAT), and glutamate receptor AMPA GluR1, known as modulatory pathways of sexual behavior, were modified in the hypothalamic medial preoptic area, the main integrating center in the control of this behavior. The additional effect of an HFHF diet and phthalates, at doses relevant for human exposure, on male sexual behavior, could be thus explained by an alteration in this neural network, revealing a specific vulnerability that requires special attention in term of public health recommendations.","PeriodicalId":308,"journal":{"name":"Environment International","volume":"37 1","pages":""},"PeriodicalIF":11.8,"publicationDate":"2025-10-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145261177","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Two decades of spatial and temporal pesticide risk to non-target invertebrates in England farmlands","authors":"Melanie Gibbs, Francesca Mancini, Claire Carvell, Gary Powney, Colin A. Harrower, Grace Skinner, Ellie Dearlove, Alexander Robinson, Carolin L. Schultz, Susan Jarvis, Richard Pywell, Ben A. Woodcock, David Spurgeon","doi":"10.1016/j.envint.2025.109856","DOIUrl":"https://doi.org/10.1016/j.envint.2025.109856","url":null,"abstract":"Pesticide impact assessment methods provide relevant approaches to quantifying risks to non-target terrestrial biodiversity in agricultural systems. Here we develop such an approach through combined analysis of pesticide usage, cropping patterns and ecotoxicological hazard datasets to generate a temporal series of maps (1994–2016) of the spatial risk of pesticides for invertebrates in England. Using data for 179 insecticides, fungicides and herbicides applied on arable crops, we assessed how pesticide risk for bees, earthworms, springtails, parasitic wasps and lacewings varied in space and time over two decades of usage shift. Change in the extent of risk associated with annual applied pesticide amounts differed depending on the organism examined. Organophosphates, pyrethroids, organochlorines and neonicotinoids all contributed to risk in bees. Insecticides, fungicides and herbicides all contributed to risk in springtails. Unexpectedly herbicides (particularly chlorotoluran) had the largest contribution to risk in lacewings, albeit with some uncertainty. Insecticides (particularly organophosphates) made the greatest contribution to risk in parasitic wasps. For earthworms, fungicides (particularly triazole fungicides and the diarylamine fluazinam) were important for risk. A noteworthy finding was that temporal risks linked to pesticide usage have changed only modestly from 1994 to 2016, despite the changes in approved authorisations and key policy such as the removal from use of most members of the neonicotinoid class of insecticides. We discuss how insights, particularly those relating to the magnitude of risk, should be considered in future studies, and how the provision of higher resolution usage data and better hazard information could improve past and future pesticide risk understanding.","PeriodicalId":308,"journal":{"name":"Environment International","volume":"2 1","pages":""},"PeriodicalIF":11.8,"publicationDate":"2025-10-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145261259","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Heavy metal risks in aquatic foods","authors":"Hao Xu, Richard Newton, David C. Love, Yong Zhao, Jogeir Toppe, Wenbo Zhang","doi":"10.1016/j.envint.2025.109831","DOIUrl":"https://doi.org/10.1016/j.envint.2025.109831","url":null,"abstract":"Aquatic foods provide essential nutrients but can also contain hazardous heavy metals like mercury, cadmium, lead, and arsenic, posing health risks. This study analysed over 138,000 records from the World Health Organization to assess heavy metal levels in aquatic foods, conducting health risk and risk–benefit assessments. Results showed that 97.6 % of aquatic products met safety standards, with mercury at 96.2 % and cadmium at 97.2 % compliance, but species standards varied, and regional compliance differences were observed. Mercury levels are relatively high in fish, while cadmium, lead, and arsenic levels are elevated in molluscs, and cadmium levels are high in cephalopods. Mercury is biomagnified through the food chain, while cadmium, lead, and arsenic exhibit biodilution. Health risk assessment showed that mercury is the primary non-cancer risk, while cadmium, lead, and arsenic are sources of cancer risk. Mercury from aquatic food consumption exceeded the non-cancer risk threshold in 69 countries, and cadmium exceeded cancer risk threshold in 20 countries, while 152 countries remained within acceptable health risk thresholds. Risk-benefit assessment indicated that the health benefits of EPA + DHA intake from aquatic food consumption outweigh the heavy metal-related risks, with net benefit limits higher than safe consumption limits. Current aquatic consumption level is below safe consumption limits, but reducing consumption of high-risk aquatic products can effectively lower health risks. This study provides a global comprehensive evidence base to inform targeted interventions, policies, industry practices, and consumer choices for mitigating risks while promoting sustainable aquatic food consumption as a vital nutritional resource.","PeriodicalId":308,"journal":{"name":"Environment International","volume":"8 1","pages":""},"PeriodicalIF":11.8,"publicationDate":"2025-10-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145261260","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Biodegradable microplastics show greater potential than conventional types in facilitating antibiotic resistance gene enrichment and transfer through viral communities","authors":"Xiaojing Hu, Haidong Gu, Yongbin Wang, Yingying Xu, Yansheng Li, Zhenhua Yu, Junjie Liu, Jian Jin, Xiaobing Liu, Guanghua Wang","doi":"10.1016/j.envint.2025.109855","DOIUrl":"https://doi.org/10.1016/j.envint.2025.109855","url":null,"abstract":"Whether and how conventional (CP) and biodegradable microplastics (BP) affect viral communities and virus-carried antibiotic resistance genes (ARGs) in agricultural soils remains largely unknown. Here, we established a soil microcosm incubation with addition of 1 % (w/w) microplastics (MPs) in maize-cultivated soil that had been treated with different fertilizers for over 10 years, and the dynamic variations of viral communities and ARG profiles were investigated using a combination of metagenomic and metatranscriptomic methods. Our results revealed that BP, but not CP, significantly decreased viral α-diversity, changed viral community structure, community resistance and taxonomic turnover in all fertilized treatments. Caudoviricetes was the most dominate viral class and BP significantly increased the abundances of viral families (<em>i.e.</em> Phycodnaviridae) in all fertilized treatments, while CP altered the viral family abundance mainly observed in manure-amended soils. Also, BP was associated with increased ARG α-diversity, altered ARG community structure and community resistance, especially at the transcriptional level. Particularly, BP significantly enriched high-risk ARGs and mobile genetic elements (MGEs) in soils regardless of fertilization regimes. Correlation analysis revealed the important role of lytic viruses in shaping the abundance of high-risk ARGs and MGEs. Furthermore, BP induced more variations in reconstructed metagenome-assembled genome (MAGs), and significantly enriched high-risk ARGs carried by phage genomes. Co-occurrence patterns revealed three Actinobacteriota MAGs as primary viral hosts sharing high-risk ARGs with phages and containing multiple MGEs. Notably, we identified four viral genomes carrying ARG transcripts identical to their hosts. Both CP and BP differentially stimulated ARG expression in these virus-host systems, with<!-- --> <!-- -->markedly<!-- --> <!-- -->stronger effects observed in manure-amended soils. In conclusion, this study revealed a high risk of ARG dissemination induced by biodegradable MP residues regardless of fertilization regimes, while conventional MPs strengthen the ARG health risks mainly in manure-amended soils.","PeriodicalId":308,"journal":{"name":"Environment International","volume":"121 1","pages":""},"PeriodicalIF":11.8,"publicationDate":"2025-10-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145261176","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Neurotoxicity of propylene glycol butyl ether: Multiomic evidence from human brainspheres","authors":"David Lopez-Rodriguez, David Pamies, Julien Boccard, Isabel Meister, Mathieu Galmiche, Tatjana Sajic, Estelle Maret, Noéline Héritier, Massimo Frangiamone, Aurélien Thomas, Nancy B. Hopf, Serge Rudaz, Marie-Gabrielle Zurich","doi":"10.1016/j.envint.2025.109852","DOIUrl":"https://doi.org/10.1016/j.envint.2025.109852","url":null,"abstract":"Exposure to solvents may contribute to the development of neurodevelopmental and neurodegenerative diseases. Glycol ethers consist in a widely used class of organic solvents leading to workers and consumers exposure via many applications. Ethylene glycol ethers are gradually being replaced by propylene glycol ethers thought to be less toxic. However, their neurotoxicity is not systematically assessed before placing them on the market. Therefore, this study investigated the potential neurotoxicity of propylene glycol butyl ether (PGBE) for which no official occupational limit has been established. To this aim, new approach methodologies have been used. Human induced pluripotent stem cells-derived BrainSpheres model was exposed to PGBE and to its assumed human main metabolite, 2-butoxypropanoic acid (2BPA). An integrative multiomic approach (transcriptomics, proteomics, metabolomics and lipidomics) was adopted to assess molecular alterations, derive benchmark concentrations and define potential mechanisms of action. PGBE was neurotoxic at occupationally relevant exposure concentrations. This was shown for the first time in human cells. Although PGBE was more cytotoxic than 2BPA, both compounds showed very similar neurotoxicity. PGBE and 2BPA strongly affected the cell cycle, induced oxidative stress and perturbed energy and lipid metabolism. They also targeted specific nervous system processes, such as axon guidance and synapse organization. Finally, 2BPA might trigger ferroptosis by increased iron uptake. Our in vitro results show an urgent need for public health authorities to carefully assess the risk glycol ethers pose to humans, to properly protect the workers as well as individuals in the general population unknowingly exposed from indoor air contaminations.","PeriodicalId":308,"journal":{"name":"Environment International","volume":"21 1","pages":""},"PeriodicalIF":11.8,"publicationDate":"2025-10-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145261178","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"National-scale investigation of EV charging stations in China reveals emerging microbial contaminant sources","authors":"Yifang Zhang, Changyi Lu, Anqi Sun, Chenhong Peng, Yong-Guan Zhu, Qing-Lin Chen","doi":"10.1016/j.envint.2025.109846","DOIUrl":"https://doi.org/10.1016/j.envint.2025.109846","url":null,"abstract":"As the adoption of electric vehicles (EVs) proliferates, EV charging stations, pivotal to transportation infrastructure, may become potential hubs for microbial contamination, posing public health risks. Here, we investigated the distribution patterns and underlying drivers of microbial contaminants on charging station surfaces across 63 service areas within the Chinese highway network. The results demonstrate the widespread distribution of human pathogenic bacteria (HPBs, 100%), human pathogenic fungi (HPFs, 49.21%), antibiotic resistance genes (ARGs, 100%), and virulence factor genes (VFGs, 100%) on charging station surfaces, with hierarchical partitioning analysis revealing that a multifaceted interplay of factors drives their distribution. The primary determinants, particularly road network density and service area size, influence the spatial pattern of ARGs and VFGs. Biotic factors significantly regulate the distribution of HPBs, whereas climatic factors emerge as the principal driver of shifts in human pathogenic fungal communities. Moreover, we assessed the potential risks associated with the detected ARGs, identifying 45 ARGs in high-risk categories Q1 and Q2 with a high prevalence (93.33%) and a pronounced abundance, particularly in southern coastal regions. These discoveries deepen our comprehension of microbial community distributions and potential assemblages on charging stations, thereby providing a robust scientific foundation for anticipatory assessments of their impacts on human health within highway systems. However, to fully understand the implications of these findings for public health, further studies should include microbial viability testing and longitudinal exposure assessments to evaluate actual infectivity and transmission potential.","PeriodicalId":308,"journal":{"name":"Environment International","volume":"114 1","pages":""},"PeriodicalIF":11.8,"publicationDate":"2025-10-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145254938","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Dried blood spots analysis for targeted and non-targeted exposomics","authors":"Vinicius Verri Hernandes, Maximilian Zeyda, Lukas Wisgrill, Benedikt Warth","doi":"10.1016/j.envint.2025.109814","DOIUrl":"https://doi.org/10.1016/j.envint.2025.109814","url":null,"abstract":"Dried blood spots (DBS) are an established sample type, widely used in newborn screening programs for monitoring metabolic diseases. Their minimally invasive nature offers great promise for assessing chemical exposures, particularly during early life stages and in large-scale epidemiological studies. However, comprehensive evaluations of key analytical parameters such as extraction efficiency and matrix effects across multiple chemical classes remain limited. Moreover, the promising approach of broadly combining targeted and non-targeted mass spectrometric data evaluation remains unexplored in DBS small-molecule omics. Here, we present an optimized LC-HRMS workflow for combined exposomic and metabolomic analysis in DBS samples. Four extraction protocols were systematically compared, with analytical performance evaluated for &gt;200 structurally diverse toxicants, pollutants, and other key biomarkers. The optimized protocol demonstrated acceptable recoveries (60–140 %) and reproducibility (median RSD: 18 %) for a majority of compounds. Matrix effects showed a median value of 76 % (median RSD: 14 %). In a proof-of-principle study, twelve exposure compounds of the target panel with diverse physicochemical properties were identified in real-life samples, with several reported for the first time in DBS human biomonitoring. Complementary non-targeted analysis further expanded the detectable chemical space, enabling reliable annotation of additional exposures. Moreover, high-confidence identification of endogenous metabolites, including amino acids, biogenic amines, fatty acids and acylcarnitines demonstrated the capacity to capture a broad snapshot of the human metabolome. These findings support the use of DBS for integrated exposomics and metabolomics applications, providing toxicological and biological insights from low-volume samples in both, prospective and retrospective studies.","PeriodicalId":308,"journal":{"name":"Environment International","volume":"89 1","pages":""},"PeriodicalIF":11.8,"publicationDate":"2025-10-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145254937","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Recombinant glutamine synthetase originating from high ammonium-assimilating Bacillus subtilis effectively reduces NH3 emissions and enhances the conversion into amino acids in liquid manure","authors":"Shaowenlan Lin, Xinfeng Han, Shujuan Chen, Fei Shen, Ke Zhao, Likou Zou","doi":"10.1016/j.envint.2025.109844","DOIUrl":"https://doi.org/10.1016/j.envint.2025.109844","url":null,"abstract":"Excessive ammonia (NH₃) emissions from livestock manure contribute to environmental pollution and nitrogen (N) loss, yet effective mitigation strategies remain limited. In this study, <em>Bacillus</em> strains capable of utilizing ammonia nitrogen (NH₄⁺) were screened from 166 probiotic strains. Nine strains exhibited utilization rates above 65.0 %, with <em>B. subtilis</em> M246 exceeding 80.0 %. Genome sequencing revealed the absence of key nitrification genes (e.g., <em>amoCAB</em>), suggesting NH₄⁺ is metabolized primarily through assimilation via the GS/GOGAT pathway. The <em>glnA</em> gene, encoding glutamine synthetase (GS), was identified as central to this process but was transcriptionally repressed under high NH₄⁺ concentrations (100 mM). To overcome this, <em>glnA</em> was heterologously expressed in <em>Pichia pastoris</em>, and the recombinant GS applied to liquid manure. GS treatments reduced NH₃ emissions by 19.57 %–45.91 %, outperforming M246 (6.45 %), and significantly decreasing total nitrogen loss (18.53 %–24.30 %) compared to CK (32.71 %, <em>p</em> &lt; 0.001) and M246 (29.31 %, <em>p</em> &lt; 0.001 for 1 % and 5 % GS; <em>p</em> = 0.003 for 2 % GS). Moreover, GS reduced nitrous oxide emissions by 18.29 %–33.59 % relative to CK, and increased readily degradable proteins, promoting their conversion into humic substances and significantly elevating glutamine (<em>p</em> &lt; 0.001) and glutamate (<em>p</em> = 0.001). GS significantly enriched microbial genera associated with N retention and mitigated emissions (<em>p</em> = 0.049); <em>Acholeplasma</em> and <em>Sedimentibacter</em> were enriched in both GS and M246 treatments, while <em>Sphaerochaeta</em> was specific to GS. Therefore, exogenous GS effectively reduces gaseous emissions, enhances N retention, promotes NH₄⁺ conversion into amino acids, and improves the biofertilizer quality of liquid manure.","PeriodicalId":308,"journal":{"name":"Environment International","volume":"204 1","pages":""},"PeriodicalIF":11.8,"publicationDate":"2025-10-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145254935","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Operational insights into carbon dynamics and decarbonization pathways in megacity water supply plants","authors":"Yuji Ji, Juchao Zhang, Bowen Lv, Chao Wang, Mengjie Yang, Yue Che, Tong Wang, Kai Yang, Kefeng Zhang, Julie B. Zimmerman","doi":"10.1016/j.envint.2025.109847","DOIUrl":"https://doi.org/10.1016/j.envint.2025.109847","url":null,"abstract":"Urban water supply systems are significant contributors to global greenhouse gas (GHG) emissions. Water supply plants in megacities, as crucial components of water supply systems, face unique challenges in achieving net-zero GHG emissions due to higher water quality and quantity requirements. However, detailed emission data and future pathways under climate change scenarios are currently lacking. In this study, we collected over 140,000 operation data entries from all 37 water supply plants in Shanghai. Based on real operational data, we have established GHG emissions inventory and projected emissions from 2023 to 2035. Future scenarios were developed through coordination with government officials, water plant managers, and academic experts. The results show that the GHG emission intensities from Shanghai’s water supply plants were 0.14 kg CO₂-eq/m³ in 2021 and 0.12 kg CO₂-eq/m³ in 2022. Suburban plants incur higher GHG emission intensity, while urban plants benefit from economies of scale. The dependence of GHG emission intensity on source water characteristics enables targeted mitigation strategy development. Scenario analysis shows implementation of five low-carbon measures under normal water quality conditions would reduce GHG emissions by up to 56.15 % by 2035, where smart platforms contribute the largest share (17.1 %). This study provides insights into low-carbon management policies and technologies for water supply plants in highly urbanized worldwide regions facing evolving environmental challenges.","PeriodicalId":308,"journal":{"name":"Environment International","volume":"26 1","pages":""},"PeriodicalIF":11.8,"publicationDate":"2025-10-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145254936","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Traffic-related air pollutant exposure and physical performance in the adult changes in thought cohort","authors":"Annie Doubleday, Magali Blanco, Sara D. Adar, Anjum Hajat, Ge Li, Eric B. Larson, Paul K. Crane, Lianne Sheppard","doi":"10.1016/j.envint.2025.109850","DOIUrl":"https://doi.org/10.1016/j.envint.2025.109850","url":null,"abstract":"<h3>Background</h3>Declining physical function is common among older adults and is associated with reduced quality of life. There is little research on the relationship between air pollution and physical limitations, though exposure to air pollution is associated with many chronic conditions that lead to worsening physical function. This is especially true for several traffic-related air pollutants (TRAPs), as these pollutants can enter the circulatory system and lead to systemic inflammation.<h3>Methods</h3>We conducted a longitudinal analysis in the Adult Changes in Thought study, a cohort of 5,305 older adults in the Puget Sound region of Washington state enrolled between 1994–2020. We estimated long-term average air pollution concentrations at residential addresses using spatial prediction models and examined associations between several TRAPs (BC, NO₂, and UFPs of various size ranges) and physical performance assessed using a modified version of the Short Physical Performance Battery (score 0–12). This measure combines three physical functioning assessments: chair-stand time, gait speed, and grip strength. We used linear mixed models to understand whether pollutant exposure was associated with physical performance, both cross-sectionally at baseline and longitudinally after adjustment for other risk factors.<h3>Results</h3>In models adjusted for baseline age, sex, race/ethnicity, education, neighborhood deprivation index and behavioral risk factors, 124 ng/m³ higher 5-year average BC and 2.1 ppb higher 5-year NO₂ exposure were suggestive of faster declines in physical performance (−0.046; 95 % CI: −0.096, 0.004) and (−0.032; 95 %CI: −0.074, 0.01), equivalent to an additional 2.6 months (−0.4, 5.6) and 1.8 months (−0.7, 4.3) of aging over 5 years, respectively. Higher UFP exposure was not associated with changes in physical performance over time.<h3>Discussion</h3>This work suggests that air pollution from traffic may impact the physical function of older adults, though more research is needed to confirm these findings.","PeriodicalId":308,"journal":{"name":"Environment International","volume":"24 1","pages":""},"PeriodicalIF":11.8,"publicationDate":"2025-10-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145254939","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}