Environment International最新文献

{"title":"Effects of a liquefied petroleum gas stove and fuel intervention on head circumference and length at birth: A multi-country household air pollution intervention network (HAPIN) trial","authors":"Hina Raheel, Sheela Sinharoy, Anaité Diaz-Artiga, Sarada S. Garg, Ajay Pillarisetti, Kalpana Balakrishnan, Marilu Chiang, Amy Lovvorn, Miles Kirby, Usha Ramakrishnan, Shirin Jabbarzadeh, Alexie Mukeshimana, Michael Johnson, John P. McCracken, Luke P. Naeher, Ghislaine Rosa, Jiantong Wang, Joshua Rosenthal, William Checkley, Thomas F. Clasen, Lisa M. Thompson","doi":"10.1016/j.envint.2024.109211","DOIUrl":"https://doi.org/10.1016/j.envint.2024.109211","url":null,"abstract":"<h3>Background</h3>Air pollution may impair child growth and cognitive development, with potential markers including birth length and head circumference.<h3>Methods</h3>The Household Air Pollution Intervention Network (HAPIN) trial was an open label multi-country-randomized controlled trial, with 3200 pregnant women aged 18–34 years (9–19 weeks of gestation) randomly assigned in a 1:1 ratio to receive liquefied petroleum gas (LPG) stove intervention compared to women continuing to cook with solid fuels for 18 months. Particulate matter ≤ 2.5 μm (PM2.5), black carbon (BC) and carbon monoxide (CO) 24-hour personal exposures were measured three times during pregnancy. Head circumference and length were measured &lt; 24 h of birth. We conducted intention-to-treat and exposure–response analyses to determine the intervention effects and associations between household air pollution (HAP) exposure during pregnancy and head circumference, head circumference-for-gestational age Z-score, length, and length-for-gestational age Z-scores at birth. The study is registered with <span><span>ClinicalTrials.gov</span><svg aria-label=\"Opens in new window\" focusable=\"false\" height=\"20\" viewbox=\"0 0 8 8\"><path d=\"M1.12949 2.1072V1H7V6.85795H5.89111V2.90281L0.784057 8L0 7.21635L5.11902 2.1072H1.12949Z\"></path></svg></span> (Identifier NCT02944682).<h3>Results</h3>Between May 2018, and Feb 2020, 3200 pregnant women were randomly assigned to intervention (n = 1593) and control groups (n = 1607) with 3060 births included in the analysis. There was a 71.9 % reduction in PM2.5 in the intervention group with similar reductions for BC and CO. Intention-to-treat analysis showed that the intervention did not affect head circumference (β = -0.01 cm, 95 %CI −0.11, 0.09), head circumference-for-gestational age Z-score (β = -0.01, 95 %CI −0.08, 0.07), or birth length (β = 0.14 cm, 95 %CI −0.01, 0.29) but did increase birth length-for-gestational age Z-score (β = 0.09, 95 %CI 0.01, 0.16). After covariate adjustment, exposure–response analysis revealed that each log-unit increase in BC was associated with a decrease in birth length-for-gestational age Z-score (β = -0.07, 95 %CI −0.13, −0.005). There was no evidence of hypothesized associations with PM2.5 or CO.<h3>Conclusion</h3>An LPG intervention reduced HAP exposure during pregnancy but had minor effects on birth length-for-gestational age Z-score. Birth length-for-gestational age was only associated with BC.<strong>Clinical Trial Registration:</strong> The study has been registered with <span><span>ClinicalTrials.gov</span><svg aria-label=\"Opens in new window\" focusable=\"false\" height=\"20\" viewbox=\"0 0 8 8\"><path d=\"M1.12949 2.1072V1H7V6.85795H5.89111V2.90281L0.784057 8L0 7.21635L5.11902 2.1072H1.12949Z\"></path></svg></span> (Identifier NCT02944682).","PeriodicalId":308,"journal":{"name":"Environment International","volume":"2 1","pages":""},"PeriodicalIF":11.8,"publicationDate":"2024-12-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142879783","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A comprehensive characterization biotransformation of chlorinated paraffin by human and carp liver microsomes via liquid chromatography-high-resolution mass spectrometry and screening algorithm","authors":"Liujun Chen, Caiming Tang, Zhiqiang Yu, Yanhong Zeng, Bixian Mai, Xiaojun Luo","doi":"10.1016/j.envint.2024.109235","DOIUrl":"https://doi.org/10.1016/j.envint.2024.109235","url":null,"abstract":"The chlorinated paraffin (CP) monomer 1,2,5,6,9,10-Hexachlorodecane (CP-4) was subjected to in vitro biotransformation using human and carp liver microsomes. Five types of CP-4 metabolites (OH–, keto-, enol-, aldehyde- and carboxy-CP-4) were identified in human liver microsomer while only mono-OH-CP-4 was found in the carp liver microsomes. Kinetic studies revealed that the formation of mono-, di-, tri-hydroxylated CP-4, keto-, enol-, and aldehyde-CP-4 in human liver microsomes was best described by substrate inhibition models, whereas the formation of carboxylated CP-4 metabolites best fit the Michaelis–Menten model. Notably, keto-CP-4, enol-CP-4 and aldehyde-CP-4 were the predominant metabolites. The estimated <em>V</em>_max values for these metabolites were significantly higher in the human liver microsomes than in the carp liver microsomes. The intrinsic hepatic clearance (CL_int) of CP-4 was higher in humans than in carp, indicating species-specific differences in its metabolism. This study also highlighted potential toxicity concerns, with computational predictions showing varying degrees of acute oral toxicity for CP-4 and its metabolites. These findings indicate significant species-specific differences in the biotransformation of CP-4, emphasizing the potential health and environmental risks associated with chlorinated paraffins and their metabolites, and underscore the need for further research to address these concerns.","PeriodicalId":308,"journal":{"name":"Environment International","volume":"25 1","pages":""},"PeriodicalIF":11.8,"publicationDate":"2024-12-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142879831","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Urbanization enhances consumer protist-driven ARGs dissemination in riverine ecosystems","authors":"Bob Adyari, Lanping Zhang, Ana Maravić, Jiaxin Chen, Laiyi Li, Mahmoud Gad, Changping Yu, Anyi Hu","doi":"10.1016/j.envint.2024.109238","DOIUrl":"https://doi.org/10.1016/j.envint.2024.109238","url":null,"abstract":"Despite the emergence of antibiotic resistance genes (ARGs) and antibiotic resistant bacteria (ARBs), how biological inter-trophic interactions, modulated by watershed urbanization, shape the resistome remains unexplored. We collected water samples from the highly urbanized (western: 65 % built land, sewage-affected) and lesser-urbanized (northern: 25 % built land, drinking water source) downstream tributaries of the Jiulong River in southeast China over dry and wet seasons. We utilized metagenomic and amplicon (16S and 18S rRNA) sequencing to investigate the relationships among microeukaryotic algae, consumer protists, bacterial communities, and the resistome. Metagenomic results showed that ARG-MGE-carrying contigs (mobile ARGs), rather than ARG-carrying contigs (non-mobile ARGs), exhibited more pronounced discrepancies between tributaries. A higher total abundance of ARGs and a greater number of co-shared ARGs between pathogen and non-pathogen bacteria were observed in the more urbanized western tributary. Structural equation modeling revealed that consumer protist-bacteria and algae-bacteria cohesions predominantly influenced the resistome in the western and northern tributaries, respectively. Additionally, consumer protists had more significant associations (511 out of 634) with bacteria carrying mobile ARGs in western tributary, while algae had more significant associations (73 out of 105) in northern tributary. These results highlight the distinct inter-trophic driving factors of the resistome modulated by watershed urbanization.","PeriodicalId":308,"journal":{"name":"Environment International","volume":"1 1","pages":""},"PeriodicalIF":11.8,"publicationDate":"2024-12-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142879782","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"High antimony resistance strain Enterobacter sp. Z1 mediates biomineralization of antimony trioxide","authors":"Zijie Zhou, Hongbo Yu, Gejiao Wang, Mingshun Li, Kaixiang Shi","doi":"10.1016/j.envint.2024.109237","DOIUrl":"https://doi.org/10.1016/j.envint.2024.109237","url":null,"abstract":"The increasing antimony (Sb) contamination prevalence poses a concern owing to its toxicity and potential carcinogenic properties. However, mechanisms underlying the microbial conversion of soluble Sb into insoluble Sb minerals remain unclear. In the present study, <em>Enterobacter</em> sp. Z1 strain demonstrated remarkable resistance to antimony potassium tartrate [Sb(III)] (&gt;250 mM) in R2A medium. Furthermore, <em>Enterobacter</em> sp. Z1 produced antimony trioxide (Sb₂O₃) via biomineralization during cultivation. Omics analysis revealed the upregulation of pyruvate metabolism and accumulation of DL-3-hydroxy-3-methylglutaryl-CoA (HMG-CoA) in the presence of Sb(III).Using pyruvate as the sole carbon source in a chemically defined medium significantly enhanced Sb(III) biomineralization ratio from 20.8 % to 90.4 % compared with that using R2A medium. Additionally, reduced Sb(III) biomineralization and intracellular pH levels were observed following <em>aceE</em> gene knockout in <em>Enterobacter</em> sp. Z1. However, this impaired phenotype was rescued by complementing the <em>aceE</em> gene or introducing purified AceE into the bacterial lysates. Notably, AceE exhibited binding affinity for Sb(III). Our findings revealed the pyruvate–HMG-CoA pathway as the mechanism underlying Sb biomineralization, facilitating the release of Sb ions from tartrate and maintaining intracellular pH stability, thereby catalyzing Sb₂O₃ synthesis. This study provides insights into the Sb biogeochemical cycle.","PeriodicalId":308,"journal":{"name":"Environment International","volume":"71 1","pages":""},"PeriodicalIF":11.8,"publicationDate":"2024-12-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142879832","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Genome-wide CRISPR-based screen identifies E2F transcription factor 1 as a Regulator and therapeutic target of aristolochic acid-induced nephrotoxicity","authors":"Ziqi Liu, Huan Gao, Guoliang Li, Yongjiang Yu, Mengxing Cui, Honghao Peng, Xinchao Guan, Xue Zhang, Zhihan Zhang, Xiaoyu Shen, Shen Chen, Daochuan Li, Liping Chen, Yongmei Xiao, Wen Chen, Lili Liu, Qing Wang","doi":"10.1016/j.envint.2024.109234","DOIUrl":"https://doi.org/10.1016/j.envint.2024.109234","url":null,"abstract":"Aristolochic Acid I (AAI) is widely present in traditional Chinese medicines derived from the Aristolochia genus and is known to cause significant damage to renal tubular epithelial cells. Genome-wide screening has proven to be a powerful tool in identifying critical genes associated with the toxicity of exogenous substances. To identify undiscovered key genes involved in AAI-induced renal toxicity, a genome-wide CRISPR library screen was conducted in the human kidney-2 (HK-2) cell line. Among the altered sgRNAs, a significant enrichment of those targeting the E2F transcription factor 1 (E2F1) gene was observed in surviving HK-2 cells in the AAI-treated group. Interestingly, the role of E2F1 had not been previously explored in studies of AAI nephrotoxicity. Further investigations revealed that E2F1 promotes apoptosis by activating the p53 signaling pathway and upregulating pro-apoptotic genes, such as BAK and BAX. Additionally, using the high-throughput experiment- and reference-guided database of traditional Chinese medicine (HERB), cannabidiol (CBD) was identified as an inhibitor of E2F1 by suppressing the activity of NF-κB pathway. In vitro and in vivo models confirmed that CBD inhibits AAI-induced upregulation of E2F1, thereby suppressing p53-mediated apoptosis. In conclusion, this study highlights the crucial role of E2F1 in AAI-induced renal cell apoptosis and identifies CBD as a novel therapeutic candidate for mitigating AAI nephrotoxicity.","PeriodicalId":308,"journal":{"name":"Environment International","volume":"31 1","pages":""},"PeriodicalIF":11.8,"publicationDate":"2024-12-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142870074","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Development of a framework to structure decision-making in environmental and occupational health: A systematic review and Delphi study","authors":"Emily Senerth, Paul Whaley, Elie Akl, Brandy Beverly, Pablo Alonso-Coello, Ezza Jalil, Jayati Khattar, Nicole R. Palmer, Andrew Rooney, Holger J. Schünemann, Kristina A. Thayer, Katya Tsaioun, Rebecca L. Morgan","doi":"10.1016/j.envint.2024.109209","DOIUrl":"https://doi.org/10.1016/j.envint.2024.109209","url":null,"abstract":"&lt;h3&gt;Background&lt;/h3&gt;Environmental and occupational health (EOH) assessments increasingly utilize systematic review methods and structured frameworks for evaluating evidence about the human health effects of exposures. However, there is no prevailing approach for how to integrate this evidence into decisions or recommendations. Grading of Recommendations Assessment, Development and Evaluation (GRADE) evidence-to-decision (EtD) frameworks provide a structure to support standardized and transparent consideration of relevant criteria to inform health decisions. This study identifies and synthesizes available EOH decision frameworks and evaluates the applicability and usability of an existing GRADE EtD perspective to advance the development of a tailored EOH EtD framework.&lt;h3&gt;Methods&lt;/h3&gt;We performed a systematic review of MEDLINE, EMBASE, and Cochrane Library, and a manual search of gray literature to identify frameworks that inform decision-making about EOH exposures from the years 2011 to 2021. We abstracted and analyzed decision considerations from each framework through narrative synthesis. Next, we conducted a two-round Delphi process, engaging stakeholders from the following perspectives within environmental and occupational health: risk assessment and management, nutrition and food safety, cancer, and socio-economic analysis. Panelists rated the relevance and wording of each consideration on a 7-point Likert scale and provided free-text comments during both phases. Considerations that did not meet predetermined thresholds were excluded.&lt;h3&gt;Results&lt;/h3&gt;Out of 5,196 unique references, we identified 22 published reports of EOH decision frameworks. We identified another 16 frameworks in a search of gray literature, totaling 38 source frameworks. We abstracted 560 individual decision considerations from these frameworks, 104 of which may contribute additional information to the guidance, scope, context, or assessment criteria of the GRADE EtD framework. In round 1 of the Delphi study, 50 decision considerations were aggregated or removed, and 9 were aggregated or removed after round 2, for a final total of 47. No new decision considerations were added in either round. We identified several differences between decision criteria that are applied in EOH and the GRADE EtD framework, including vocabulary that is specific to EOH (e.g., toxicity, the precautionary principle), and granularity of the EOH decision considerations (e.g., detailed signaling questions to assess feasibility and resources required). However, this study did not identify any EOH decision criteria that are completely distinct from the GRADE EtD framework.&lt;h3&gt;Conclusions&lt;/h3&gt;Findings of this mixed-methods study comprise a foundation for a GRADE EtD that is applicable for use in EOH decision-making, with implications for approaches to regulation of environmental and occupational exposures and the formulation of recommendations for interventions to prevent or mitigate undesirable health ","PeriodicalId":308,"journal":{"name":"Environment International","volume":"32 1","pages":""},"PeriodicalIF":11.8,"publicationDate":"2024-12-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142867171","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"PFOA, PFOS and PFHxS toxicokinetic considerations for the development of an in vivo approach for assessing PFAS relative bioavailability in soil","authors":"Albert L. Juhasz, Farzana Kastury, Ruby Jones, Mahima Seeborun, Tanya Caceres, Carina Herde, Michelle Cavallaro, Sarah Dilmetz, Joshua Hutchings, Yevgeniya Grebneva, Chris Desire, Peter Hoffmann","doi":"10.1016/j.envint.2024.109232","DOIUrl":"https://doi.org/10.1016/j.envint.2024.109232","url":null,"abstract":"A Sprague-Dawley rat model was utilized to elucidate perfluorooctanoic acid (PFOA), perfluorooctanesulfonic acid (PFOS) and perfluorohexanesulfonic acid (PFHxS) toxicokinetics with a goal of developing an <em>in vivo</em> approach for quantifying PFAS relative bioavailability in impacted soil. Following single dose administration (gavage) of ∼ 0.2–2000 µg kg⁻¹ BW of PFOA, PFOS or PFHxS, differences in PFAS blood, organ and excreta concentrations were observed over 120 h although linear dose responses were determined for area under the blood plasma time curves (AUC; PFOA, PFHxS), liver accumulation (LA: PFOS) and urinary excretion (UE; PFOA, PFHxS). Oral and intravenous dose (∼20 µg kg⁻¹ body weight) comparisons highlighted the high absolute bioavailability of PFOA (AUC: 100.3 ± 23.4 %; UE: 94.7 ± 26.6 %), PFOS (LA: 102.9 ± 15.6 %) and PFHxS (AUC: 88.3 ± 15.1 %; UE: 90.9 ± 7.3 %). Two spiked (¹⁴C-PFOA: 4360 ± 218 µg kg⁻¹) and two PFAS impacted soils (PFOS: 1880–2250 µg kg⁻¹; PFHxS: 61.2–65.5 µg kg⁻¹) were utilized to measure PFAS relative bioavailability in soil matrices. In all soils, PFAS relative bioavailability was &gt; 86 % (PFOA: 87.0–90.9 %; PFOS: 86.1–90.4 %; PFHxS: 86.5–97.0 %) although the method could quantify bioavailability reductions (25.6–88.9 %) when hydrophobic and electrostatic interactions were enhanced through the addition of carbon-based amendments (5–10 % w/w).","PeriodicalId":308,"journal":{"name":"Environment International","volume":"24 1","pages":""},"PeriodicalIF":11.8,"publicationDate":"2024-12-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142867167","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Heat-related mortality in Mexico: A multi-scale spatial analysis of extreme heat effects and municipality-level vulnerability","authors":"Lara Schwarz, Chen Chen, Javier Emmanuel Castillo Quiñones, L.C. Aguilar-Dodier, Kristen Hansen, Jaime Reyes Sanchez, David J.X. González, Gordon McCord, Tarik Benmarhnia","doi":"10.1016/j.envint.2024.109231","DOIUrl":"https://doi.org/10.1016/j.envint.2024.109231","url":null,"abstract":"Understanding effects of extreme heat across diverse settings is critical as social determinants play an important role in modifying heat-related risks. We apply a multi-scale analysis to understand spatial variation in the effects of heat across Mexico and explore factors that are explaining heterogeneity. Daily all-cause mortality was collected from the Mexican Secretary of Health and municipality-specific extreme heat events were estimated using population-weighted temperatures from 1998 to 2019 using Daymet and WorldPop datasets. We analyzed the association between single-day extreme heat events defined at the 99th percentile of the same-day maximum temperature and mortality, and seven heat threshold metrics based on relative and absolute scales were considered as sensitivity analyses. A time-stratified case-crossover was applied to evaluate heat impacts across 32 states in Mexico. A within-community matched design with Bayesian Hierarchical model explored effects across 2456 municipalities. A random-effects <em>meta</em>-regression was applied to understand which municipality-level socio-demographic characteristics such as education, age and housing predicted observed spatial heterogeneity. Extreme heat increased the odds of mortality overall, and this was consistent across extreme heat thresholds. At the state level, extreme heat events showed highest impact on mortality in Tabasco [OR: 1.23, 95% CI: 1.17, 1.30]. The municipality-level spatial analysis showed substantial differences across regions with highest effects observed along the eastern, southwestern and Sonora coasts. Municipalities with older populations, higher marginalization, lower education, and poorer housing conditions were more vulnerable to heat effects. Understanding the differential risks of extreme heat events at varying scales is important to prioritize at-risk populations in action plans and policies to reduce their burden.","PeriodicalId":308,"journal":{"name":"Environment International","volume":"22 1","pages":""},"PeriodicalIF":11.8,"publicationDate":"2024-12-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142867176","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Influence of prenatal hexachlorobenzene, PCB and selenium levels on growth trajectories in the first year of life: Findings from the NEHO birth cohort","authors":"Ilaria Cosentini, Silvia Ruggieri, Paolo Colombo, Fabrizio Bianchi, Liliana Cori, Melania Casella, Elisa Eleonora Tavormina, Fabio Cibella, Gaspare Drago","doi":"10.1016/j.envint.2024.109225","DOIUrl":"https://doi.org/10.1016/j.envint.2024.109225","url":null,"abstract":"Prenatal exposure to endocrine-disrupting chemicals (EDCs) may impact postnatal growth trajectories, increasing the risk of various diseases later in life. This issue is of particular concern in industrially contaminated areas, where environmental matrices contain mixtures of pollutants. This study aimed to evaluate the associations between cord serum concentrations of organochlorine pollutants (hexachlorobenzene-HCB and polychlorinated biphenyls-PCBs) and essential elements (EEs), and weight growth trajectories during the first year of life. We analyzed data from 237 infants enrolled in the Neonatal Environment and Health Outcomes (NEHO) cohort. Using the Group-Based Multivariate Trajectory modeling approach, we identified three distinct growth trajectories from birth to 12 months, classified as “Higher,” “Normal,” and “Lower.” Multinomial regression models were then applied to the whole sample and stratified by sex to assess the associations between individual exposures and the identified child growth trajectories. HCB exposure was associated with an increased risk of reduced growth during the first year of life in both the overall sample and among males [higher vs normal: OR_Male = 0.33 (95 % CI_Male:0.12;0.87); lower vs normal: OR_Male = 2.17 (95 % CI_Male:0.94;5.00)]. Conversely, PCB-180 exposure was linked to higher growth only in females [higher vs normal: OR_Female = 24.10 (95 % CI_Female:1.33;438.24)]. Elevated levels of selenium in cord serum were negatively associated with excessive growth [higher vs normal: OR_Overall = 0.50 (95 % CI_Overall: 0.26;0.97)]. These findings suggest sex-specific effects on the growth profile during the first year of life, with different chemical exposures contributing to different outcomes.","PeriodicalId":308,"journal":{"name":"Environment International","volume":"23 1","pages":""},"PeriodicalIF":11.8,"publicationDate":"2024-12-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142857571","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Corrigendum to “Large scale survey of enteric viruses in river and waste water underlines the health status of the local population” [Environ. Int. 79 (2015) 42–50]","authors":"B. Prevost, F.S. Lucas, A. Goncalves, F. Richard, L. Moulin, S. Wurtzer","doi":"10.1016/j.envint.2024.109197","DOIUrl":"https://doi.org/10.1016/j.envint.2024.109197","url":null,"abstract":"The authors regret a typing error in Table 1 concerning the sequence of the NVGI_P5318 probe for norovirus I detection. Modified LNA bases (in <strong><u>bold underlined</u></strong> in corrected revision) do not appear in the original published version and resulted in poor PCR efficiency.","PeriodicalId":308,"journal":{"name":"Environment International","volume":"171 1","pages":""},"PeriodicalIF":11.8,"publicationDate":"2024-12-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142857575","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}