Environment International最新文献

{"title":"Sustaining low-cost PM2.5 monitoring networks in South-Asian Countries: technical challenges and solutions","authors":"Talha Saeed ,&nbsp;Muhammad Mahad Khaliq ,&nbsp;Michael Howard Bergin ,&nbsp;Prakash V. Bhave ,&nbsp;Noora Khaleel ,&nbsp;Enna Mool ,&nbsp;Mahesh Senarathna ,&nbsp;Shahid Uz Zaman ,&nbsp;Shatabdi Roy ,&nbsp;Abdus Salam ,&nbsp;Jas Raj Subba ,&nbsp;Suhaib Malik ,&nbsp;Darren Y. Wu ,&nbsp;Muhammad Fahim Khokhar","doi":"10.1016/j.envint.2026.110275","DOIUrl":"10.1016/j.envint.2026.110275","url":null,"abstract":"<div><div>The need to monitor South Asia’s air quality stems from its significant negative effects on human and environmental health. Traditional, regulatory-grade air quality monitoring systems have proven costly to operate and very difficult to maintain in most South-Asian countries. Low-cost sensor (LCS) networks have been touted as a viable alternative, but the challenges to sustain them have not been evaluated or thoroughly documented. The acceptance of such monitors, specifically by regulatory agencies, across South-Asian countries is still lacking. Lack of acceptance is due to prevailing myths (especially, in the regulatory circles of South-Asian countries) about their accuracy, precision, consistency, dependability, maintenance, and calibration concerns. The present study fills that knowledge gap through a systematic multi-country empirical analysis while also providing evidence-based solutions to enhance the longevity of LCS across diverse operational environments. Specifically, this study describes strategies and maintenance plans for operating large LCS networks of TSI BlueSky (8143) Sensors across several South-Asian countries, with a focus on problems caused by power outages, power surges, weather conditions, and continued exposure to high amounts of dust and pollution. The article provides further support that incorporating LCS networks into the regulatory framework can facilitate the enforcement of environmental regulations and legislation against polluters. The goal is to develop a more reliable and long-lasting air quality monitoring system that will assist regional environmental regulatory authorities in reducing air pollution-related health hazards and consequent socio-economic disruptions.</div></div>","PeriodicalId":308,"journal":{"name":"Environment International","volume":"211 ","pages":"Article 110275"},"PeriodicalIF":9.7,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147756187","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Multi-omics integration identifies PFOS-associated immune signatures in Kawasaki disease","authors":"Jia Quan ,&nbsp;Juxiang Tu ,&nbsp;Dan Li ,&nbsp;Zongli Zhang ,&nbsp;Lisha Xue ,&nbsp;Tao Li ,&nbsp;Shibing Xi","doi":"10.1016/j.envint.2026.110279","DOIUrl":"10.1016/j.envint.2026.110279","url":null,"abstract":"<div><div>Kawasaki disease (KD), also known as mucocutaneous lymph node syndrome (MCLS), remains the leading cause of acquired heart disease in children younger than 5 years; coronary artery lesions (CALs) develop in 20–30% of untreated patients. Although environmental exposures have been implicated, evidence is inconclusive, and systematic analyses linking exposure profiles to KD-associated immune signatures are still lacking. Despite rising global incidence, the etiology remains unclear, and systematic exploration of potential associations between environmental exposure and KD immune signatures is insufficient. This study employed integrated multi-omics analysis to explore potential associations between perfluorooctane sulfonate (PFOS) exposure and KD immune transcriptomic signatures. By intersecting KD transcriptomic signatures with PFOS toxicological targets, we identified 83 candidate genes significantly enriched in immune-inflammatory pathways. Permutation testing demonstrated PFOS-specific enrichment compared with structurally related compounds (enrichment fold = 2.45; <em>P</em> &lt; 0.001). Machine learning combined with SHAP analysis identified four candidate hub genes (ALPL, IL4R, PGD, SLC22A4) showing consistent expression patterns across independent cohorts. Computational molecular simulations predicted potential binding interfaces between PFOS and candidate proteins, with more favorable docking scores compared to non-fluorinated analogs (6.4–8.9 kcal/mol). Single-cell RNA sequencing revealed hub gene expression in CD14/CD16 Mono and CD8⁺ T, which exhibited elevated PFOS response scores. Transcription factor network analysis predicted CEBPB and CDX2 as candidate regulators associated with hub gene expression, with their regulatory activities correlated with PFOS response scores (activity differences and score-dependent monotonic trends; both <em>P</em> &lt; 2.2 × 10⁻¹⁶). These computational findings suggest potentially PFOS-associated transcriptomic signatures in KD, providing candidate targets for subsequent mechanistic validation and epidemiological studies.</div></div>","PeriodicalId":308,"journal":{"name":"Environment International","volume":"211 ","pages":"Article 110279"},"PeriodicalIF":9.7,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147803636","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Neglected but potentially significant emissions of unintentional persistent organic pollutants from primary copper smelting industry.","authors":"Yuxiang Sun, Changzhi Chen, Qiuting Yang, Jianghui Yun, Minghui Zheng, Guorui Liu","doi":"10.1016/j.envint.2026.110282","DOIUrl":"https://doi.org/10.1016/j.envint.2026.110282","url":null,"abstract":"<p><p>Copper smelting is an important source of unintentional persistent organic pollutants (POPs). Yet emission assessment and inventories remain limited by two key field-evidence gaps: (i) scarce measurement-based emission factors (EFs) for primary copper smelting and (ii) a lack of quantitative constraints on fugitive-derived POP releases. In this study, we conduct field measurements at three primary copper smelting plants and compare POP burdens across end-of-pipe stack gas and a secondary-capture stream capturing fugitive-derived gas. For primary copper smelting using an Ausmelt furnace with electrostatic precipitation as the end-of-pipe control, EFs of polychlorinated dibenzo-p-dioxins and dibenzofurans (PCDD/Fs), dioxin-like polychlorinated biphenyls, and polybrominated dibenzo-p-dioxins and dibenzofurans were estimated at 0.03-0.14, 0.004-0.023, and 0.055-0.062 μg TEQ t⁻¹, respectively. In contrast, reported PCDD/F EFs could be as high as 0.65 μg TEQ t⁻¹ for oxygen-enriched side-blown furnace smelting equipped with baghouse filtration. These results indicate that emissions from primary copper smelting warrant attention in regions with concentrated production activity. The secondary-capture stream exhibited comparable POP concentrations to those in end-of-pipe emissions. Fugitive-related pathways could contribute emissions on the same order as end-of-pipe releases. Fugitive releases should be explicitly considered to reduce systematic underestimation in inventories and associated risk assessments.</p>","PeriodicalId":308,"journal":{"name":"Environment International","volume":"211 ","pages":"110282"},"PeriodicalIF":9.7,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147831914","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Integrating machine learning and metabolomics to identify PFAS-associated metabolic alterations related to lung cancer risk","authors":"Jianli Qu ,&nbsp;Xinguo Zhang ,&nbsp;Qianxun Jin ,&nbsp;Yasheng Guo ,&nbsp;Haomiao Yu ,&nbsp;Guoyin Zhan ,&nbsp;Weili Mao ,&nbsp;Sicheng Xiang ,&nbsp;Meirong Zhao ,&nbsp;Hangbiao Jin","doi":"10.1016/j.envint.2026.110276","DOIUrl":"10.1016/j.envint.2026.110276","url":null,"abstract":"<div><div>Per- and polyfluoroalkyl substances (PFAS) are pervasive environmental contaminants increasingly implicated in lung cancer risk. However, the metabolic features and biological pathways associated with human PFAS exposure in relation to lung cancer remain poorly characterized. We conducted a nested case-control study within the Quzhou Environment Exposure and Human Health cohort (408 lung cancer cases and 421 controls) to examine whether serum PFAS concentrations are associated with lung cancer risk and to identify metabolic alterations associated with both PFAS exposure and lung cancer. Seven PFAS were quantified and associations assessed with multivariable logistic regression, Bayesian Kernel Machine Regression, and Weighted Quantile Sum (WQS) regression models, alongside high-resolution serum metabolomics (1,403 features) and machine learning classification. Higher serum levels of perfluorooctanoic acid (PFOA), perfluorononanoate (PFNA), perfluorohexane sulfonate (PFHxS), perfluorooctanesulfonic acid (PFOS) and 6:2 chlorinated polyfluoroether sulfonic acid (6:2Cl-PFESA) were associated with increased risk, with dose–response patterns for several chemicals. Highest-quartile odds ratios were 7.94 for PFOA, 3.82 for PFNA, 4.55 for PFHxS, 2.84 for PFOS, and 5.54 for 6:2Cl-PFESA (all trend <em>p</em> &lt; 0.05). Mixture analyses supported a positive joint effect (WQS <em>β</em> = 1.95, 95% CI 1.61–2.38), with greatest weights for PFOA, PFHxS and PFNA. Metabolomics revealed broad metabolic alterations in cases (886 features up-regulated and 202 down-regulated). Among the evaluated metabolomics-based models, the least absolute shrinkage and selection operator (LASSO) showed the highest performance under the present analytical framework. The LASSO model identified candidate discriminative metabolites including adenosine triphosphate, citrulline, L-carnitine, 1-methylhistidine, and ethanolamine (<em>β</em> = 1.05–51.04, <em>p</em> &lt; 0.05). Pathway enrichment analysis indicated significant perturbations in phosphatidylcholine biosynthesis, phospholipid biosynthesis, phosphatidylethanolamine biosynthesis, and aspartate metabolism. This study provides novel evidence that PFAS exposure is associated with metabolic alterations that may be relevant to lung cancer-related processes.</div></div>","PeriodicalId":308,"journal":{"name":"Environment International","volume":"211 ","pages":"Article 110276"},"PeriodicalIF":9.7,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147803627","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Metabolome-wide association study to decipher the risk of exogenous chemical exposure to liver cancer in a Chinese nested case-control cohort","authors":"Chengnan Fang ,&nbsp;Pengwei Guan ,&nbsp;Huan Yang ,&nbsp;Xiaokun Wang ,&nbsp;Lei You ,&nbsp;Qi Li ,&nbsp;Xiaolin Wang ,&nbsp;Yaorui Ye ,&nbsp;Jinhu Fan ,&nbsp;Guowang Xu ,&nbsp;Youlin Qiao ,&nbsp;Xinyu Liu","doi":"10.1016/j.envint.2026.110274","DOIUrl":"10.1016/j.envint.2026.110274","url":null,"abstract":"<div><div>Exogenous chemical exposures are a global health concern due to their hepatotoxic potential, yet the extent to which endogenous metabolic disruption bridges these exposures to long-term liver cancer risk remains unclear. In a nested case-control study within a prospective Chinese cohort (n = 200), we conducted a metabolome-wide association analysis integrating 254 serum exogenous chemical residues with 478 endogenous metabolites to characterize pre-diagnostic metabolic disorders occurring up to 10 years before liver cancer onset and to delineate exposure-risk relationships. Individuals who later developed liver cancer exhibited pronounced metabolic perturbations, particularly involving bile acid metabolism, acylcarnitine pathways, glycerophospholipid turnover, sphingomyelin composition, and acylglycerol metabolism. A candidate early-warning panel comprising Phe/Tyr, FFA 24:1, PC (16:0_20:5), TG (18:1_18:1_21:0), and TG (18:3_17:1_18:2) was identified for liver cancer risk stratification. Exposure to salmeterol, diethylstilbestrol, and dibutyl phosphate showed positive associations with liver cancer risk, and mediation analysis highlighted tyrosine, PC (19:0_18:2), and SM (d18:1/24:1) as significant intermediators, suggesting hepatocarcinogenesis arises from the combined impact of exogenous chemical exposure and endogenous metabolic disorders. Overall, these findings indicate that early disturbances in bile acid, lipid, and amino acid metabolism precede clinical diagnosis by years and may serve as mechanistic links and early-warning biomarkers for exposure-related liver carcinogenesis.</div></div>","PeriodicalId":308,"journal":{"name":"Environment International","volume":"211 ","pages":"Article 110274"},"PeriodicalIF":9.7,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147739212","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Corrigendum to “Bisphenol-A from environment macro-circulation to human micro-circulation: a novel link to abdominal aortic aneurysm” [Environ. Int. 210 (2026) 110217]","authors":"Shuli Zhang, Feilong Zhang, Dandan Liu, Xiaozeng Wang, Yajing Guo, Nan Zhang, Chunge Dang, Ruichen Wang","doi":"10.1016/j.envint.2026.110267","DOIUrl":"https://doi.org/10.1016/j.envint.2026.110267","url":null,"abstract":"<strong>The incorrect content:</strong> Funding: This work was supported by the National Natural Science Foundation of China (82200535), and the Liaoning Science and Technology Project (2022JH2/101300054).","PeriodicalId":308,"journal":{"name":"Environment International","volume":"22 1","pages":""},"PeriodicalIF":11.8,"publicationDate":"2026-04-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147756179","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Systematic review on internal exposure to per- and polyfluoroalkyl substances (PFAS) and risk of ischemic heart diseases.","authors":"Moritz L Bauer, Cornelia Weikert, Sven Knüppel, Bernhard H Monien, Klaus Abraham, Juliane Menzel","doi":"10.1016/j.envint.2026.110278","DOIUrl":"https://doi.org/10.1016/j.envint.2026.110278","url":null,"abstract":"<p><p>Per- and polyfluoroalkyl substances (PFAS) may elevate blood lipids, suggesting that PFAS may also target the cardiovascular system. This systematic review aimed to investigate the relationship between internal human exposure to main PFAS, i.e., perfluorooctanoic acid (PFOA), perfluorooctanesulfonic acid (PFOS), perfluorononanoic acid (PFNA), and perfluorohexanesulfonic acid (PFHxS) and ischemic heart diseases (IHD). Two systematic literature searches were performed in MEDLINE and EMBASE - most recently on January 8, 2025. Eligible studies analyzed associations between individual blood PFAS exposure and IHD among humans. Risk of bias was assessed using the OHAT Risk of Bias Rating Tool and evidence was synthesized using structured tables and vote counting based on direction of effect, as meta-analyses and dose-response analyses did not provide meaningfully interpretable results. The 16 studies included comprised 79,313 participants. Seven studies estimated rate ratios (RR) and nine estimated odds ratios (OR). Associations between PFOA exposure and IHD (RR) were small and exposure levels were heterogeneous. In the vote counting analysis of the association between PFOA exposure and IHD, 82.4% (95%-CI: 56.6%-96.2%) of effect estimates (RR) pointed in the harmful direction (low certainty). A harmful tendency was less pronounced for PFOS and IHD, with 60.0% (95%-CI: 14.7%-94.7%) of RR and 46.4% (95%-CI 27.5%-66.1%) of OR indicating a harmful relationship. For PFHxS, PFNA, and the sum of PFAS, the overall direction of the vote counting results differed between RR and OR (very low or low certainty). The relationship between PFAS and IHD remains unclear, so further longitudinal studies investigating dose-dependent effects are required.</p>","PeriodicalId":308,"journal":{"name":"Environment International","volume":"211 ","pages":"110278"},"PeriodicalIF":9.7,"publicationDate":"2026-04-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147831880","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Extractable organofluorine (EOF) and target PFAS, including trifluoroacetic acid (TFA), in human serum from a Norwegian cohort, with a case study on the impact of fluorinated pharmaceuticals","authors":"Leo W.Y. Yeung, Trine Husøy, Enmiao Jiao, Welmoed Nauta, Dorte Herzke, Line Småstuen Haug, Jana Geuer, Monica Andreassen, Hubert Dirven","doi":"10.1016/j.envint.2026.110280","DOIUrl":"https://doi.org/10.1016/j.envint.2026.110280","url":null,"abstract":"This study investigated the amount and proportion of unidentified organofluorine (UOF) in human serum and assessed short-term variability in exposure using extractable organofluorine (EOF) analysis and a fluorine mass balance approach. Serum samples were obtained from the well-characterized EuroMix cohort, comprising residents living in and around Oslo, Norway, collected between September 2016 and November 2017. Short-term intra-individual variability was evaluated using 72 paired serum samples collected 2–3 weeks apart. An extended target list of 64 PFAS, including trifluoroacetic acid (TFA), was applied to quantify identified and unidentified EOF. UOF accounted for up to 81% of EOF (median: 38%) in EuroMix samples. In 36% of paired samples, EOF concentrations varied by more than 25% over the 2–3-week interval, indicating the presence of compounds with relatively short biological half-lives. TFA was the most abundant individual PFAS detected, with median concentrations approximately twice those of PFOS. In a separate case study, serum samples from individuals using the fluorinated pharmaceutical Fluoxetine showed substantially elevated EOF and TFA concentrations (EOF: median 140 ng F/mL; TFA: median 27.7 ng/mL) compared with samples from individuals not using Fluoxetine (EOF: median &lt; 8 ng F/mL; TFA: median 6.22 ng/mL). These findings indicate that fluorinated pharmaceuticals may contribute significantly to circulating EOF and TFA in humans. The large fraction of UOF and the widespread occurrence of TFA highlight the need to identify their sources relevant to human exposure. Together, these findings indicate that current PFAS including TFA biomonitoring approaches capture only a fraction (estimated to be 50%) of total human exposure to fluorinated substances and highlight the need to complement target analysis with fluorine mass balance approaches in future exposure assessment.","PeriodicalId":308,"journal":{"name":"Environment International","volume":"97 1","pages":""},"PeriodicalIF":11.8,"publicationDate":"2026-04-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147756170","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Corrigendum to “Street-view-measured greenspace components and childhood myopia: A population-based cross-sectional and prospective cohort study” [Environ. Int. 210 (2026) 110230]","authors":"Yingan Li, Yuzhou Zhang, Charlene C. Yim, Lixian Su, Ka Wai Kam, Poemen Chan, Patrick Ip, Wei Zhang, Alvin Young, Chi Pui Pang, Clement C. Tham, Li Jia Chen, Mei Po Kwan, Jason C. Yam","doi":"10.1016/j.envint.2026.110266","DOIUrl":"https://doi.org/10.1016/j.envint.2026.110266","url":null,"abstract":"The authors regret a typographical error occurred in the Abstract (Methods section) concerning the definition of myopia. The published text incorrectly states “≤− 80.50 diopters”, whereas the correct value is “≤− 0.50 diopters”.","PeriodicalId":308,"journal":{"name":"Environment International","volume":"20 1","pages":"110266"},"PeriodicalIF":11.8,"publicationDate":"2026-04-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147739208","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Corrigendum to \"Towards safe plastic recycling: A novel framework for identifying chemicals of concern in plastic waste\" [Environ. Int., 209 (2026) 110177].","authors":"Golnoush Abbasi, Miguel Las Heras Hernández, Émilien Bourgé, Mikael Harju, Marina Jennifer Hauser, Vladimir Nikiforov","doi":"10.1016/j.envint.2026.110265","DOIUrl":"https://doi.org/10.1016/j.envint.2026.110265","url":null,"abstract":"","PeriodicalId":308,"journal":{"name":"Environment International","volume":" ","pages":"110265"},"PeriodicalIF":9.7,"publicationDate":"2026-04-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147758624","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}