Environment International最新文献

{"title":"Country-level impact of climate change on maternal and newborn health: Associations between temperature, precipitation, maternal mortality, stillbirth, and neonatal mortality in the Democratic Republic of the Congo","authors":"Carrie Ngongo, Donal Bisanzio, Gabriella Corrigan, Karl B. Angendu, Alisha Smith-Arthur, Brian Hutchinson, Pierre Akilimali","doi":"10.1016/j.envint.2025.109564","DOIUrl":"https://doi.org/10.1016/j.envint.2025.109564","url":null,"abstract":"<h3>Background</h3>Evidence connecting extreme heat to maternal and newborn health outcomes is needed at country level, especially in tropical areas. DHIS2 (District Health Information Software 2) collects aggregated population health data by health zone in the Democratic Republic of the Congo (DRC).<h3>Methods</h3>Drawing from DHIS2 records of 22·7 million DRC births 2018–2023, spatio-temporal modeling assessed associations between maternal mortality, stillbirth, and neonatal mortality and same-month, remotely sensed temperature, precipitation, anomalous high temperature (&gt;95th percentile), and anomalous heavy precipitation (&gt;95th percentile), controlling for month, year, remoteness, and health zone.<h3>Findings</h3>Temperatures &gt; 34 °C and anomalous heavy precipitation were strongly associated with increases in same-month stillbirth and maternal mortality and less strongly associated with neonatal mortality. The stillbirth rate rose by 2·3/1,000 births for every degree increase above 34 °C (95 % CI: 1·9; 2·5) or by 5·9/1,000 births in months &gt; 95th percentile (32·9 °C; 95 % CI: 5·1; 6·7). Maternal mortality rose by 27·3 deaths/100,000 live births for every degree increase above 34 °C (95 % CI: 19·1; 35·7) or by 95·3 deaths/100,000 live births in months &gt; 95th percentile (95 % CI: 71·3; 119·4). Months with anomalous heavy precipitation were associated with an increase of 5·4 stillbirths/1,000 births (95 % CI: 4·8; 6·2) and with 120 maternal deaths/100,000 live births (95 % CI: 100·9; 139·5).<h3>Interpretation</h3>DHIS2 data offer a readily available opportunity to assess associations between climate and country-level population health outcomes. Further work is needed to hone and evaluate effective approaches that protect mothers and newborns in the face of projected warming and rainfall changes. Risk-based planning, geographic targeting, and stakeholder coordination will support appropriate, context-specific responses.","PeriodicalId":308,"journal":{"name":"Environment International","volume":"29 1","pages":""},"PeriodicalIF":11.8,"publicationDate":"2025-05-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144165128","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Teleost fish metamorphosis under the influence of estrogenic hormones: targeting the thyroid axis – a literature review","authors":"Nathalie Leroux, Sébastien Baekelandt, Patrick Kestemont","doi":"10.1016/j.envint.2025.109570","DOIUrl":"https://doi.org/10.1016/j.envint.2025.109570","url":null,"abstract":"Estrogens, whether naturally excreted by humans and livestock or introduced through pharmaceuticals, are endocrine-disrupting chemicals (EDCs) with strong estrogenic activity. While their effects on the reproductive functions of teleosts are well-documented, their influence on other vital biological functions such as metamorphosis remains understudied. Teleost metamorphosis represents a critical life stage involving profound morphological, physiological, and behavioral transformations essential for survival. This process is tightly regulated by multiple endocrine factors, with the thyroid axis playing a central role. This review synthesizes current knowledge on the impact of estrogens on teleost metamorphosis, focusing on the thyroid hormonal pathway. Several studies have examined estrogen effects on specific aspects of metamorphosis, such as skeletal development, salinity adaptation, and migratory behaviours. However, these investigations often remain fragmented and lack an integrative analysis of metamorphosis as a whole. Furthermore, few studies directly link estrogen-induced disruptions to thyroid axis alterations, despite findings of such links in other aquatic species, such as amphibians, and with other EDCs. While the impact of estrogens on the thyroid cascade of teleosts has been documented, observations are sometimes contradictory due to experimental and methodological differences, complicating data interpretation and hindering mechanistic understanding. Nonetheless, available studies suggest that estrogens are potent modulators of thyroid function at multiple levels of the hormonal cascade. Such disruptions may significantly affect thyroid-regulated functions, including metamorphosis, whose long-term ecological implications warrant greater attention. Given the environmental threat posed by estrogenic pollution, driven by human activities such as hormonal contraceptive use and agricultural runoff, further research in this field is necessary.","PeriodicalId":308,"journal":{"name":"Environment International","volume":"19 1","pages":""},"PeriodicalIF":11.8,"publicationDate":"2025-05-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144165130","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Research progress of microcystin-LR toxicity to the intestine, liver, and kidney and its mechanism","authors":"Yaqi Wang, Xiaodie Zhou, Yue Yang, Jun Liu, Fei Yang","doi":"10.1016/j.envint.2025.109547","DOIUrl":"https://doi.org/10.1016/j.envint.2025.109547","url":null,"abstract":"Global warming and eutrophication of water bodies have exacerbated the occurrence of cyanobacterial blooms in recent years. Microcystin-LR (MC-LR) produced by cyanobacterial blooms is present in water bodies. Humans and livestock are at significant risk of exposure to MC-LR through drinking water, consuming contaminated food, or inhalation of aerosols containing MC-LR. This article systematically summarizes the formation, fate, and distribution of MC-LR in the body, and explores its toxic effects and mechanisms on the multiple organs containing intestines, liver and kidneys. The study comparatively elucidated MC-LR exerted toxicity primarily through the following classical mechanisms: (1) inhibiting protein phosphatase 2A (PP2A), thereby affecting signaling pathways such as JNK/P38, MAPK/ERK, and PI3K/AKT, leading to abnormal cell proliferation; (2) inducing oxidative stress, such as IL-6, NLRP3, α-SMA, which promotes inflammation and fibrosis. Additionally, we summarized new mechanisms: (1) MC-LR affects mitophagy or induces mitochondrial structure damage; (2) MC-LR can induce intestinal microbiota dysbiosis, which in turn causes liver and kidney damage via the “gut-liver” axis and “gut-kidney” axis. This study presents the first systematic analysis of the multi-organ toxic effects induced by MC-LR, elucidates potential specific and shared toxic mechanistic pathways and proposes some future research directions to mitigate MC-LR-associated health risks.","PeriodicalId":308,"journal":{"name":"Environment International","volume":"33 1","pages":""},"PeriodicalIF":11.8,"publicationDate":"2025-05-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144165126","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Fine particulate matter air pollution and longitudinal gray matter development changes during early adolescence: variation by neighborhood disadvantage level","authors":"Alethea V. de Jesus, Hedyeh Ahmadi, Daniel A. Hackman, Carlos Cardenas-Iniguez, Jared Schachner, Joel Schwartz, W. James Gauderman, Jiu-Chiuan Chen, Megan M. Herting","doi":"10.1016/j.envint.2025.109561","DOIUrl":"https://doi.org/10.1016/j.envint.2025.109561","url":null,"abstract":"The adolescent brain is vulnerable to ambient air pollution. Importantly, community-level factors – such as neighborhood disadvantage – that co-occur with air pollution may further enhance this vulnerability and impact brain development. The current study investigated if neighborhood disadvantage moderates the association between residential fine particulate matter (PM_2.5) pollution and adolescent brain development, including longitudinal changes in cortical thickness, surface area, and subcortical/white matter volume from ages 9–13 years (n = 8,321 participants from the ABCD Study®; 12,634 observations). We found that, in more disadvantaged neighborhoods, higher PM_2.5 levels were associated with greater age-related cortical thinning in temporal areas and in most regions of the occipital lobe. Furthermore, independent of neighborhood disadvantage, higher PM_2.5 exposure was associated with larger age-related surface area decreases in parietal, occipital, and temporal regions, but smaller age-related increases in right cerebral white matter volume and frontal and temporal region surface area. Similarly, higher PM_2.5 exposure was independently associated with greater age-related cortical thinning in the frontal regions, cingulate, and insula, but smaller age-related cortical thickening in temporal regions. Findings have policy implications for air quality improvements alongside investment in disadvantaged neighborhoods to bolster adolescent brain development.","PeriodicalId":308,"journal":{"name":"Environment International","volume":"5 1","pages":""},"PeriodicalIF":11.8,"publicationDate":"2025-05-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144165127","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Increased particle mass deposition on lung tissue due to industrial and waste-burning activities","authors":"Anusmita Das, Erwin W. Karg, George A. Ferron, Jürgen Schnelle-Kreis, Anil Kumar Mandariya, Gazala Habib, Alfred Wiedensohler, Mira L. Pöhlker, Ralf Zimmermann, Ajit Ahlawat","doi":"10.1016/j.envint.2025.109548","DOIUrl":"https://doi.org/10.1016/j.envint.2025.109548","url":null,"abstract":"Understanding airborne particle mass deposition in the lungs is crucial for assessing health effects, particularly in regions with severe air pollution. While several studies have modelled lung deposition, there is limited information on lung tissue deposition that incorporates factors like hygroscopicity and density in polluted environments or source-specific exposures. This study examines the impact of atmospheric aerosol properties, including particle number size distribution, effective density, and hygroscopic growth, on lung tissue deposition using data from a measurement campaign in Delhi, India.Using the Hygroscopic Particle Lung Deposition (HPLD) model, the number (<em>TD_n</em>) and mass (<em>TD_m</em>) of tissue-deposited particles were calculated for various episodes: biomass burning (<em>BB</em>), chloride (<em>Cl</em>), hydrocarbon-like organic aerosol (<em>HOA</em>), and relatively clean (<em>RC</em>) periods. Chloride episodes, linked to industrial and waste burning activities, showed the highest deposition rate at 28 pg cm⁻²h⁻¹, followed by <em>BB</em> (22pg cm⁻²h⁻1), <em>HOA</em> (17pg cm⁻²h⁻1), and <em>RC</em> (14pg cm⁻²h⁻1). In addition, Incorporating hygroscopicity and density increased deposition estimates by 1.8–2.8 times.This study underscores the importance of quantifying tissue deposition doses for improving exposure assessments, particularly in highly polluted regions where elevated particulate levels exacerbate lung inflammation, respiratory issues, and cancer risk.","PeriodicalId":308,"journal":{"name":"Environment International","volume":"58 1","pages":""},"PeriodicalIF":11.8,"publicationDate":"2025-05-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144165133","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Associations of road traffic noise with adipose tissue depots and hepatic fat content – Results from the German National Cohort (NAKO)","authors":"Fiona Niedermayer, Susanne Rospleszcz, Clara Matthiessen, Barbara Hoffmann, Sophia Stoecklein, Tobias Haueise, Tobias Norajitra, Christopher L. Schlett, Johanna Nattenmüller, Fabian Bamberg, Jürgen Machann, Matthias Günther, Jochen Hirsch, Rajini Nagrani, Henry Völzke, Claudia Meinke-Franze, Norbert Hosten, Tobias Nonnenmacher, Bettina Katalin Budai, Viktoria Palm, Annette Peters","doi":"10.1016/j.envint.2025.109566","DOIUrl":"https://doi.org/10.1016/j.envint.2025.109566","url":null,"abstract":"Little is known about the relation between traffic noise exposure, an established environmental risk factor for cardiovascular disease, and early obesity-related risk markers such as adipose tissue (AT) and hepatic fat. Therefore, we aimed to assess associations of long-term road traffic noise exposure with AT depots measures from whole-body magnetic resonance imaging (MRI). We analyzed cross-sectional data from 11,343 participants from the population-based German National Cohort (NAKO) who underwent MRI examination between 2014 and 2016, considering visceral (VAT), subcutaneous abdominal (SCAAT), subcutaneous thoracic AT (SCTAT) and hepatic fat content as outcomes. Annual road traffic noise (L_den) data from the year 2017 (source: central EIONET data repository) was used to calculate weighted mean noise levels on a continuous scale within 10 and 100-meter buffers of participants’ residencies. Among 11,101 participants with complete outcome data, 48.7 % were women, and the mean age was 51.9 years. Higher annual L_den was associated with increased AT depots and hepatic fat content in men (e.g., VAT: 1.72 %-change [95 % confidence interval: [0.14 %; 3.30 %]; SCAAT: 2.18 %-change [0.43 %; 3.93 %], hepatic fat content: 3.57 %-change [1.41 %; 5.78 %] per 10 dB(A) increase in L_den (10 m)) and women (e.g., VAT: 3.13 %-change [1.09 %; 5.18 %]; SCAAT: 2.38 %-change [0.55 %; 4.20 %], hepatic fat content: 3.08 %-change [1.00 %; 5.21 %] per 10 dB(A) increase in L_den (10 m)). Associations were robust with all outcomes after adjusting for air pollutants and surrounding greenness, and effect modification by obesity and hypertension was observed for SCAAT, SCTAT and hepatic fat content. Our findings indicate that annual exposure to road traffic noise is associated with increased adipose tissue depots and hepatic fat content, and thus present novel evidence for the cross-sectional association between noise and early MRI-derived metabolic health markers.","PeriodicalId":308,"journal":{"name":"Environment International","volume":"5 1","pages":""},"PeriodicalIF":11.8,"publicationDate":"2025-05-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144165135","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The role of heatwave characteristics in cardiovascular mortality in the Eastern Mediterranean region","authors":"Panayiotis Kouis, Kyriaki Psistaki, Panayiotis K. Yiallouros, Anastasia Κ. Paschalidou","doi":"10.1016/j.envint.2025.109563","DOIUrl":"https://doi.org/10.1016/j.envint.2025.109563","url":null,"abstract":"Heatwaves constitute a major public health risk and climate change is projected to exacerbate this risk by increasing their intensity, duration, and frequency. This study focused on the Eastern Mediterranean and explored the impact of heatwave characteristics on cardiovascular (CVD) mortality in three typical sites (Athens, Thessaloniki and Cyprus). We demonstrated that the heatwave order and timing in the season, as well as the intensity and evolution, may determine the exposure–response relationship. Specifically, heatwave days occurring during the 1st heatwave were associated with a higher increase in CVD mortality risk compared to heatwave days of the 2nd and 3rd (or subsequent) event (e.g. for Athens: 28.3 %, 95%CI: 23.2 %, 33.6 % for 1st event; 17.0 %, 95% CI: 9.8 %, 24.7 % for 2nd event), while hotter heatwave days also amplified the health impact (increase in CVD risk per °C above the site-specific heatwave threshold for Athens: 11.79 %, 95%CI: 9.80 %, 13.79 %; for Thessaloniki: 18.44 %, 95 % 13.81 %, 23.13 %; for Cyprus: 36.14 %, 95% CI: 23.95 %, 49.14%). Heatwave days lagging from the onset of the event resulted in increased CVD mortality risk (e.g. for Athens: 7.96 %, 95%CI: 1.04 %, 15.02 % for the 1st heatwave day; 36.31 %, 95% CI; 27.59 %, 45.44 % for the 4th heatwave day and above) and the time-distance of heatwaves from the warm season onset was also found to be associated with increased CVD mortality. These findings suggest that tailored heatwave action plans and risk communication strategies could mitigate the higher risks associated with specific characteristics of more intense and prolonged heatwaves anticipated in the future.","PeriodicalId":308,"journal":{"name":"Environment International","volume":"145 1","pages":""},"PeriodicalIF":11.8,"publicationDate":"2025-05-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144165132","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Down-regulation of serum SIRT6 levels is associated with an increased risk of chronic intestinal inflammation in children exposed to airborne particulate matter and polycyclic aromatic hydrocarbons from e-waste","authors":"Tengyang Huang, Xijin Xu, Shuqin Chen, Zhiping Liu, Yu Huang, Xia Huo, Guangcan Chen","doi":"10.1016/j.envint.2025.109549","DOIUrl":"https://doi.org/10.1016/j.envint.2025.109549","url":null,"abstract":"Informal e-waste recycling releases airborne particulate matter (PM) and polycyclic aromatic hydrocarbons (PAHs), which are linked to intestinal barrier dysfunction and chronic inflammation. SIRT6, a histone deacetylase, modulates inflammation by suppressing NF-κB signaling, but its role in mitigating e-waste pollutant-induced childhood enteritis remains unclear. This cross-sectional study evaluated associations between e-waste exposure, intestinal inflammation, and SIRT6 levels in 217 preschool children from Guiyu (e-waste-exposed, <em>n</em> = 109) and Haojiang (non-exposed control, <em>n</em> = 108), China. Airborne pollutant exposure was quantified via the Air Quality Composite Index (AQCI) and average daily dose (ADD) for PM_2.5, PM₁₀, NO₂, and SO₂. Urinary PAH metabolites, serum SIRT6, inflammatory markers (GM-CSF, IL-10), and intestinal barrier biomarkers (IFABP, endotoxins) were measured using GC/MS, ELISA, and automated hematology analyzers. Dietary patterns, residential proximity to e-waste sites, and gastrointestinal symptoms were assessed via questionnaires. Statistical analyses included Spearman correlations, multivariate regression, and Bayesian kernel machine regression (BKMR) to evaluate pollutant effects on SIRT6 and inflammation. Children residing in Guiyu demonstrated significantly elevated urinary PAH metabolites and higher ADD of PM_2.5, PM₁₀, NO₂, and SO₂ compared to reference populations. Concurrently, this cohort exhibited biomarker patterns indicative of intestinal barrier compromise, including elevated IFABP and systemic endotoxin levels. Serum analyses revealed quantifiable reductions in SIRT6 and GM-CSF concentrations, accompanied by increased circulating monocytes and lymphocytes. Notably, BKMR modeling identified non-linear U-shaped associations between mixed PM/PAH exposures and progressive SIRT6 suppression. Proximity to e-waste sites, lower parental education, and poor household ventilation correlated with heightened pollutant exposure and gastrointestinal morbidity. Chronic e-waste exposure was associated with decreased serum SIRT6 levels and concurrent elevation of intestinal inflammatory biomarkers in children. Our cross-sectional analysis revealed significant correlations between SIRT6 downregulation, altered GM-CSF/IL-10 signaling profiles, and disrupted macrophage-Treg homeostasis. These observational findings suggest SIRT6 may serve as a potential protective mediator in environmental enteritis.","PeriodicalId":308,"journal":{"name":"Environment International","volume":"53 1","pages":""},"PeriodicalIF":11.8,"publicationDate":"2025-05-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144165134","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Personal exposure to PM2.5 and its chemical components in individuals with COPD: associations with lifestyle and lung function","authors":"Jiyoung Hwang, Eri Saikawa, Alexander Avramov, Siran Chen, Sandeep Shelly, Khaled Altartoor, Tomorrow Bowen, Munish Luthra, Adviteeya N. Dixit, Adam M. Klein","doi":"10.1016/j.envint.2025.109560","DOIUrl":"https://doi.org/10.1016/j.envint.2025.109560","url":null,"abstract":"Exposure to fine particulate matter (PM_2.5) is a major environmental health concern, particularly for patients with Chronic Obstructive Pulmonary Disease (COPD). However, research examining how PM_2.5 exposure and lifestyle influence disease severity remains limited. This study aimed to assess personal PM_2.5 exposure levels and analyze its chemical composition among COPD patients in Atlanta, Georgia, along with investigating the association between exposure levels, lifestyles, and lung functions. We enrolled 28 COPD patients, and a Pulmonary Function Test (PFT) was performed prior to the exposure measurement. Personal PM_2.5 exposure was measured over a 24-hour period using MicroPEM, followed by a survey to assess participants’ lifestyle and track their daily activities. Concentrations of PM_2.5 and 33 inorganic elements were quantified and Black Carbon (BC), Brown Carbon (BrC) and Environmental Tobacco Smoke (ETS) were estimated from filter-based optical measurements. Associations between pollutant exposure, lifestyle factors, and lung function were evaluated using multivariable linear regression. PM_2.5 levels ranged from 1.81 to 154.48 µg/m³, showing substantial individual variability. Window opening hours were associated with increased levels of PM_2.5, BC, Br, K, and S, while smoking was correlated with elevated ETS, Ca, and K. Time spent outdoors was linked to higher Cu and Ti, while cooking duration was associated with elevated Na and Ca. In addition, BC and K showed negative associations with Forced Vital Capacity (FVC), indicating potential impact on lung function. These findings highlight the importance of considering both lifestyle factors and PM_2.5 composition in developing strategies to reduce exposure and mitigate lung function impacts.","PeriodicalId":308,"journal":{"name":"Environment International","volume":"36 1","pages":""},"PeriodicalIF":11.8,"publicationDate":"2025-05-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144165131","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Air pollution and anti-Müllerian hormone: the Doetinchem Cohort Study","authors":"Runyu Zou, Amanda Durkin, Annelien de Kat, Yvonne T. van der Schouw, Gerard Hoek, W.M.Monique Verschuren, Roel Vermeulen, Virissa Lenters","doi":"10.1016/j.envint.2025.109565","DOIUrl":"https://doi.org/10.1016/j.envint.2025.109565","url":null,"abstract":"Emerging epidemiologic studies have investigated the relationship between exposure to air pollutants and anti-Müllerian hormone (AMH), a biomarker for ovarian reserve. However, findings remain inconclusive, and there is a lack of longitudinal studies with repeated AMH measurements, which could better characterize the impact of air pollutants on ovarian reserve across the lifespan. In 2574 women with a mean baseline age of 37.6 years from a prospective population-based cohort in the Netherlands, we used linear mixed models to investigate the associations between long-term exposure to four regulated air pollutants (NO₂, O₃, PM₁₀, and PM_2.5) and longitudinal serum AMH levels. Annual average concentrations of air pollutants were estimated at baseline residential addresses using an enhanced European hybrid land-use regression model. Serum AMH was measured up to five times over a period exceeding 20 years using the highly sensitive picoAMH assay. Results showed that, despite marginal AMH differences after age 60, there were no associations between the air pollutant exposures and AMH levels across the reproductive lifespan in single-pollutant models, and the observed differences were further attenuated in two-pollutant models. In addition, none of the air pollutants were related to age at menopause. To summarize, we did not find clinically relevant associations between long-term air pollutant exposure and longitudinal AMH levels. Further studies are needed to confirm these findings in diverse populations and higher exposure scenarios, as well as to explore vulnerable periods of exposure during early life.","PeriodicalId":308,"journal":{"name":"Environment International","volume":"58 1","pages":""},"PeriodicalIF":11.8,"publicationDate":"2025-05-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144154156","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}