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Non-targeted screening of organic micropollutants in drinking water: Evidence of contamination from purification systems and plastic materials 饮用水中有机微污染物的非目标筛选:净化系统和塑料材料污染的证据
IF 11.8 1区 环境科学与生态学
Environment International Pub Date : 2025-07-24 DOI: 10.1016/j.envint.2025.109685
Kailin Shen, Daeho Kang, Heewon Jang, Junho Jeon
{"title":"Non-targeted screening of organic micropollutants in drinking water: Evidence of contamination from purification systems and plastic materials","authors":"Kailin Shen, Daeho Kang, Heewon Jang, Junho Jeon","doi":"10.1016/j.envint.2025.109685","DOIUrl":"https://doi.org/10.1016/j.envint.2025.109685","url":null,"abstract":"Concerns over organic micropollutants (MPs) in drinking water are growing due to their persistence in aquatic environments and the limitations of conventional tap water treatment methods. Alternative pathways, including water purifiers, cause potential human exposure to MPs through<!-- --> <!-- -->drinking water. This study investigates potential human exposure to MPs through drinking water by analyzing five sample sets: (1) water from 12 campus purifiers, (2) water from tap and 2 purifiers over 12 weeks, (3) purified water from 21 public buildings, (4) bottled water from sources across Korea, and (5) sonicated water extract of purifier-filter-elements. All samples were pretreated via solid-phase extraction and then<!-- --> <!-- -->analyzed to identify MPs through suspect and nontarget screening using liquid chromatography high-resolution mass spectrometry.<!-- --> <!-- -->A total of 41 MPs were tentatively identified through MS/MS spectral pattern diagnosis, including plasticizers, plastic derivatives, organophosphorus flame retardants (OPFRs), pesticides, and pharmaceuticals. Among these, 24 MPs were confirmed with standards, 6 were quantified with standards, and 4 were semi-quantified without standards. Notably, four OPFRs were found in purified water (up to 3900 ng/L) and tap water (up to 130 ng/L). Additionally, plastic-derived PA6 oligomers were detected in purified water, with concentrations reaching 5300 ng/L.<!-- --> <!-- -->The presence of OPFRs and plastic-derived oligomers in household purified water was suggested to be linked to the water’s contact with plastic tanks and pipes, as well as the use of fiber wipers during purifier cleaning. The findings suggest the potential utility of non-targeted monitoring of drinking water and support its use to inform future targeted monitoring efforts.","PeriodicalId":308,"journal":{"name":"Environment International","volume":"46 1","pages":""},"PeriodicalIF":11.8,"publicationDate":"2025-07-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144693751","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Future control pathways of PM2.5 constituents and emission sources under different SSPs from a health perspective 健康视角下不同ssp下PM2.5组分及排放源的未来控制路径
IF 11.8 1区 环境科学与生态学
Environment International Pub Date : 2025-07-24 DOI: 10.1016/j.envint.2025.109698
Guangling Chen, Li Chen, Die Su, Shuangqin Yang, Jing Li, Hui Zhang, Shuang Gao, Zhipeng Bai, Merched Azzi
{"title":"Future control pathways of PM2.5 constituents and emission sources under different SSPs from a health perspective","authors":"Guangling Chen, Li Chen, Die Su, Shuangqin Yang, Jing Li, Hui Zhang, Shuang Gao, Zhipeng Bai, Merched Azzi","doi":"10.1016/j.envint.2025.109698","DOIUrl":"https://doi.org/10.1016/j.envint.2025.109698","url":null,"abstract":"PM<sub>2.5</sub> constituents may exhibit greater toxicity than the total mass of PM<sub>2.5</sub>. However, the number of avoided premature deaths due to the changes in PM<sub>2.5</sub> constituents concentrations and the the control pathways under future different Shared Socioeconomic Pathways (SSPs) are unclear. We projected the avoided premature deaths related to different health endpoints (all-cause disease, cardiovascular disease, respiratory disease, ischemic heart disease and stroke) attributable to PM<sub>2.5</sub> constituents (BC, NH<sub>4</sub><sup>+</sup>, NO<sub>3</sub><sup>−</sup>, OM and SO<sub>4</sub><sup>2−</sup>) from 2022 to 2100 in China across different SSPs. The SSP1-2.6 scenario was expected to achieve approximately 380 thousand avoided premature deaths attributable to all PM<sub>2.5</sub> constituents. With age structure taken into account, the total avoided premature deaths were expected to increase by 37.5 %, 61.2 % and 80.5 % under SSP1-2.6, SSP2-4.5 and SSP5-8.5 scenarios, respectively. The total avoided premature deaths attributable to all-cause disease were expected to be mainly attributable to SO<sub>4</sub><sup>2−</sup> due to a relatively large gap between SO<sub>4</sub><sup>2−</sup> concentration in 2022 and the goals of SSPs as well as a higher β value, suggesting the priority of controls on residential coal combustion, power, and industrial boilers. The avoided premature deaths showed the highest sensitivity to BC and it is essential to prioritize the controls of residential coal combustion, residential biofuel combustion and off-road mobile source. Each province is advised to take targeted control measures in different seasons and for specific age groups.","PeriodicalId":308,"journal":{"name":"Environment International","volume":"115 1","pages":""},"PeriodicalIF":11.8,"publicationDate":"2025-07-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144693750","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Future temperature-related mortality in Latin American cities under climate change and population scenarios 气候变化和人口情景下拉丁美洲城市未来与温度相关的死亡率
IF 11.8 1区 环境科学与生态学
Environment International Pub Date : 2025-07-23 DOI: 10.1016/j.envint.2025.109694
Maryia Bakhtsiyarava, Josiah L. Kephart, Brisa N. Sanchez, M.V.S. Ramarao, Saravanan Arunachalam, Nelson Gouveia, Iryna Dronova, Leah H. Schinasi, Usama Bilal, Waleska T. Caiaffa, Andrea Jaffe, Ana V. Diez Roux, Daniel A. Rodriguez
{"title":"Future temperature-related mortality in Latin American cities under climate change and population scenarios","authors":"Maryia Bakhtsiyarava, Josiah L. Kephart, Brisa N. Sanchez, M.V.S. Ramarao, Saravanan Arunachalam, Nelson Gouveia, Iryna Dronova, Leah H. Schinasi, Usama Bilal, Waleska T. Caiaffa, Andrea Jaffe, Ana V. Diez Roux, Daniel A. Rodriguez","doi":"10.1016/j.envint.2025.109694","DOIUrl":"https://doi.org/10.1016/j.envint.2025.109694","url":null,"abstract":"<h3>Background</h3>In Latin America, climate change, urbanization, and an aging population are intensifying health risks from extreme temperatures. To accurately assess future temperature-related mortality impacts, evidence that integrates key demographic factors—such as the dynamics of population age composition, mortality rates, and population size—is essential.<h3>Methods</h3>We projected the impact of nonoptimal temperatures on all-age and age-specific mortality during 2045–2054 for 326 cities in Latin America. Our analysis combined city-level daily mortality counts, gridded temperature data, downscaled and bias-corrected temperature simulations, and demographic data. We projected temperature-mortality impacts under two climate change scenarios while also considering changing population size, age structure, and age-specific mortality rates.<h3>Findings</h3>By 2045–2054, the percentage of heat-attributable deaths under the most extreme temperature scenario will more than double from 0.87 % (95 % CI 0.77; 0.96) to 2.06 % (95% CI 1.80; 2.33), but cold-related mortality will decrease. Population growth and aging will exacerbate heat-related risks and offset reductions in cold-related deaths. For example, changes in population age structure will drive an increase in the heat-related mortality rate of 176% from baseline for a moderate temperature scenario.<h3>Interpretation</h3>Beyond temperature changes, demographic shifts—particularly population growth and aging—will significantly amplify mid-century temperature impacts on mortality, underscoring the need for targeted climate adaptation and public health strategies.","PeriodicalId":308,"journal":{"name":"Environment International","volume":"18 1","pages":""},"PeriodicalIF":11.8,"publicationDate":"2025-07-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144693755","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Supervised machine learning for nutrient and contaminant profiling and benefit-risk assessment of Arctic seafood 监督机器学习用于北极海产品的营养和污染物分析和利益风险评估
IF 11.8 1区 环境科学与生态学
Environment International Pub Date : 2025-07-23 DOI: 10.1016/j.envint.2025.109699
Quang Tri Ho, Ole Jakob Nøstbakken, Monica Sanden, Lene Secher Myrmel, Martin Wiech, Annette Bernhard, Bente M. Nilsen, Amund Maage, Lisbeth Dahl
{"title":"Supervised machine learning for nutrient and contaminant profiling and benefit-risk assessment of Arctic seafood","authors":"Quang Tri Ho, Ole Jakob Nøstbakken, Monica Sanden, Lene Secher Myrmel, Martin Wiech, Annette Bernhard, Bente M. Nilsen, Amund Maage, Lisbeth Dahl","doi":"10.1016/j.envint.2025.109699","DOIUrl":"https://doi.org/10.1016/j.envint.2025.109699","url":null,"abstract":"Arctic seafood is a crucial source of nutrients due to its richness in proteins, omega-3 polyunsaturated fatty acids, vitamins and minerals. However, contaminants including Hg and persistent organic pollutants (POPs) in fish may pose a health concern for consumers. This study aimed to profile concentration patterns including interspecies and regional variations between Barents Sea and Norwegian Sea, and to explore correlations of nutrients and contaminants in five commercially important Arctic marine fish species using supervised machine learning applied to analytical data. These multivariate patterns were subsequently used as input in Monte Carlo simulations to assess the benefit and risk of fish consumption. Except for Atlantic mackerel, fish from the Barents Sea generally had lower concentrations of Hg and POPs than those from the Norwegian Sea, while nutrient concentrations were largely comparable across both regions. Fatty fish, especially Atlantic mackerel and herring had higher nutrient scores than lean fish. Consuming lean fish from 300 to 450 g per week did not entail risk of excessive Hg, dioxins and DL-PCBs exposure. Although weekly consumption of more than 190 g of mackerel or 130 g of herring from the Norwegian Sea, may exceed the tolerable weekly intake for dioxins and DL-PCBs (P &gt; 0.05), both species are excellent sources of EPA + DHA, Se and vitamin D. The nutritional benefits may outweigh the potentially risk of dioxins and DL-PCBs exposure. Arctic fish rich in many essential nutrients are important for food security.","PeriodicalId":308,"journal":{"name":"Environment International","volume":"118 1","pages":""},"PeriodicalIF":11.8,"publicationDate":"2025-07-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144693749","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
PXR-dependant dysregulation of glucose metabolism induced by chronic exposure to NOAEL-level pesticide cocktail in mice 长期暴露于noael水平的农药鸡尾酒诱导小鼠pxr依赖性葡萄糖代谢失调
IF 11.8 1区 环境科学与生态学
Environment International Pub Date : 2025-07-22 DOI: 10.1016/j.envint.2025.109697
Yannick Dauwe, Lucile Marie, Marina Grimaldi, Patrick Balaguer, Yannick Lippi, Veronique Gayrard, Laila Mselli-Lakhal
{"title":"PXR-dependant dysregulation of glucose metabolism induced by chronic exposure to NOAEL-level pesticide cocktail in mice","authors":"Yannick Dauwe, Lucile Marie, Marina Grimaldi, Patrick Balaguer, Yannick Lippi, Veronique Gayrard, Laila Mselli-Lakhal","doi":"10.1016/j.envint.2025.109697","DOIUrl":"https://doi.org/10.1016/j.envint.2025.109697","url":null,"abstract":"Pesticides are essential in modern agriculture but raise concerns about long-term metabolic effects, particularly through nuclear receptor activation. This study examines the impact of chronic exposure to a cocktail of five pesticides (dieldrin, propiconazole, boscalid, bupirimate, and pendimethalin) with or without tributyltin (TBT) on glucose and lipid metabolism in mice, focusing on the role of the constitutive androstane receptor (CAR) and pregnane X receptor (PXR). TBT was included for its strong affinity for RXR, a key heterodimerization partner of CAR and PXR, to assess whether RXR activation modulates or amplifies the metabolic effects of pesticide exposure. Results showed that pesticide exposure at NOAEL levels altered CAR and PXR dependent metabolic pathways. CAR knockout mice exhibited reduced free fatty acids and fasting glycemia, while PXR activation led to lower peak glycemia in oral glucose tolerance tests. Transcriptomic analysis identified disrupted pathways linked to glucose uptake and insulin sensitivity. These findings suggest that low-dose pesticide exposure can subtly affect metabolism via nuclear receptor interactions. The inclusion of TBT emphases RXR’s role in metabolic regulation. Overall the study underscores the need to consider cocktail effects in risk assessment.","PeriodicalId":308,"journal":{"name":"Environment International","volume":"667 1","pages":""},"PeriodicalIF":11.8,"publicationDate":"2025-07-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144684751","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Global analysis links ambient fine particulate matter to bacterial antimicrobial resistance based on 110,000 + genomes 基于11万个 + 基因组的全球分析将环境细颗粒物与细菌抗菌素耐药性联系起来
IF 11.8 1区 环境科学与生态学
Environment International Pub Date : 2025-07-22 DOI: 10.1016/j.envint.2025.109696
Wenyong Zhou, Zexuan Wen, Bowen Sun, Renjie Chen, Haiyan Xiong, Weibing Wang
{"title":"Global analysis links ambient fine particulate matter to bacterial antimicrobial resistance based on 110,000 + genomes","authors":"Wenyong Zhou, Zexuan Wen, Bowen Sun, Renjie Chen, Haiyan Xiong, Weibing Wang","doi":"10.1016/j.envint.2025.109696","DOIUrl":"https://doi.org/10.1016/j.envint.2025.109696","url":null,"abstract":"Antimicrobial resistance (AMR) is a global health challenge. Recent overwhelming evidence suggests a possible association between fine particulate matter (PM<sub>2.5</sub>) and bacterial AMR. However, the PM<sub>2.5</sub>-AMR association was poorly understood. In this global analysis, we aim to provide in-depth and comprehensive insights into the PM<sub>2.5</sub>-AMR association. Based on multiple global databases, two Bayesian multivariable models (negative binomial regression model and logistic regression model) with different lag time were used to estimate the association, quantify the lag-response effects, and identify potential effect modifiers. A total of 114,488 isolates with genome data, collected between 2000 and 2022 from 139 countries and regions, were examined. For every 10 μg/m<sup>3</sup> increase in PM<sub>2.5</sub> exposure over the past 12 months, there was a corresponding 11.2 % increase (95 % CI: 10.6 %, 11.7 %) in the percentage of total resistance genes per isolate and an odds ratio of 1.18 (95 % CI: 1.17, 1.20) for carrying at least one resistance gene. There was a dose–response relationship between PM<sub>2.5</sub> level and AMR. The PM<sub>2.5</sub>-AMR association might be highest at cumulative exposure during the past 12 months, and modified by bacterial species, sample sources, environmental factors, and other national-level economic, medical, and social factors. To summarize, we found significant associations between PM<sub>2.5</sub> exposure and AMR. Further studies are needed in phenotypic resistance data and possible intervention experiments in animals or humans to confirm these findings.","PeriodicalId":308,"journal":{"name":"Environment International","volume":"13 1","pages":""},"PeriodicalIF":11.8,"publicationDate":"2025-07-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144684752","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
An exposomics analysis of 125 biomarkers of exposure to food contaminants and biomarkers of oxidative stress: a randomized cross-over chrononutrition trial of healthy adults 125个食物污染物暴露生物标志物和氧化应激生物标志物的暴露组学分析:健康成人随机交叉时间营养试验
IF 11.8 1区 环境科学与生态学
Environment International Pub Date : 2025-07-19 DOI: 10.1016/j.envint.2025.109682
Hayley Kunde, Elina I. Ioannou, Jasmin Chovatiya, Ravikumar Jagani, Pantelis Charisiadis, Manish Arora, Syam S. Andra, Konstantinos C. Makris
{"title":"An exposomics analysis of 125 biomarkers of exposure to food contaminants and biomarkers of oxidative stress: a randomized cross-over chrononutrition trial of healthy adults","authors":"Hayley Kunde, Elina I. Ioannou, Jasmin Chovatiya, Ravikumar Jagani, Pantelis Charisiadis, Manish Arora, Syam S. Andra, Konstantinos C. Makris","doi":"10.1016/j.envint.2025.109682","DOIUrl":"https://doi.org/10.1016/j.envint.2025.109682","url":null,"abstract":"<h3>Background</h3>Contaminants in food counteract the beneficial effects of nutrients by interfering with their absorption/distribution/metabolism/excretion characteristics and implicated in chronic disease pathogenesis. The CIRCA CHEM chrononutrition trial was used to expand and replicate its earlier results from two biomarkers of exposure to pesticides to 125 biomarkers of exposure to food contaminants/xenobiotics, using exposomics.<h3>Objectives</h3>We determined i) the effect of time restricted eating (TRE) consumption of fruits and vegetables either in light or dark phases of the 24-h period (five-a-day portions for 14 days), within <em>ad libitum</em> diet on 125 biomarkers of exposure to food-associated contaminants in healthy adults, ii) the chrono-metabolism patterns in biomarker concentrations across/within treatment phases (light vs dark); and iii) the contaminants associated with oxidative stress, including 4-hydroxy-2-nonenal mercapturic acid (HNEMA) and 8-iso prostaglandin F2α (F2A8IP).<h3>Methods</h3>We characterized the temporal patterns of the TRE treatment effectiveness on biomarkers of exposure using an exposome-wide association study (ExWAS) approach, by applying linear mixed-effects models (LME) to evaluate treatment phase effects and interactions of treatment x time. Associations between contaminants and oxidative stress were further explored using LASSO regression, followed by additional LME, while adjusting for sociodemographics, body mass index and cortisol.<h3>Results</h3>A wide within-subject concentration variability for most biomarkers of exposure to food contaminants/xenobiotics was observed. The ExWAS approach confirmed that TRE significantly influenced the concentration and temporal patterns of multiple food contaminants/xenobiotics, including pesticides, smoking, volatile organics, phytoestrogens, parabens, and flame retardants, demonstrating their chrono-differentiated metabolism, depending on the timing of fruit and vegetable consumption within the 24-h period. Some of them (pesticides and VOCs) exhibited significant associations with lipid oxidative stress.<h3>Discussion</h3>Understanding how the circadian rhythm interacts with metabolic systems to influence the metabolism of both nutrients/bioactives and food contaminants would be of high importance in the era of precision health and precision nutrition","PeriodicalId":308,"journal":{"name":"Environment International","volume":"19 1","pages":""},"PeriodicalIF":11.8,"publicationDate":"2025-07-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144664389","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Global, regional and national cardiovascular mortality costs associated with non-optimal temperatures over two decades (2000–2021) 二十年(2000-2021年)与非最佳温度相关的全球、区域和国家心血管死亡率
IF 10.3 1区 环境科学与生态学
Environment International Pub Date : 2025-07-18 DOI: 10.1016/j.envint.2025.109693
Sasan Faridi , Hao Yin , Mohammad Khanizadeh , Robert D. Brook , Thomas Münzel , Omar Hahad , Mohammad Sadegh Hassanvand , Kazem Naddafi , Sanjay Rajagopalan , Khurram Nasir , Sadeer Al-Kindi
{"title":"Global, regional and national cardiovascular mortality costs associated with non-optimal temperatures over two decades (2000–2021)","authors":"Sasan Faridi ,&nbsp;Hao Yin ,&nbsp;Mohammad Khanizadeh ,&nbsp;Robert D. Brook ,&nbsp;Thomas Münzel ,&nbsp;Omar Hahad ,&nbsp;Mohammad Sadegh Hassanvand ,&nbsp;Kazem Naddafi ,&nbsp;Sanjay Rajagopalan ,&nbsp;Khurram Nasir ,&nbsp;Sadeer Al-Kindi","doi":"10.1016/j.envint.2025.109693","DOIUrl":"10.1016/j.envint.2025.109693","url":null,"abstract":"<div><h3>Background and Aims</h3><div>We designed this study to investigate the mortality costs of cardiovascular disease (CVD) deaths associated with non-optimal, cold and hot temperatures—as an emerging environmental risk factor for CVD—globally, regionally, and nationally between 2000 and 2021.</div></div><div><h3>Methods</h3><div>We obtained disease burden estimates from the Global Burden of Disease (GBD) 2021 study and estimated the cost of CVD deaths linked to non-optimal, cold and hot temperatures using two valuation measures: the age-adjusted and age-invariant value of a statistical life (VSL). To identify key drivers of mortality costs, we performed multiple linear regression (MLR) analysis, examining the effects of climate, socio-economic, and demographic factors.</div></div><div><h3>Results</h3><div>The global mortality costs due to CVD increased by 51 %, rising from US$550.8 billion to US$833.2 billion using the age-adjusted VSL between 2000 and 2021. Cold temperatures accounted for the majority of the global mortality costs linked to non-optimal temperatures, between US$519.6 and US$745.5 billion over the study period. High-income GBD super-region demonstrated the greatest mortality costs, contributing 36–63 % of global mortality cost of CVD due to non-optimal temperatures over the study period. Among the top 5 countries (the USA, China, Russia, Japan, and Germany) with the greatest mortality cost of CVD deaths attributable to non-optimal temperatures, China experienced the most significant increase in mortality costs, rising by over 700 % during the study period and reaching nearly US$230 billion in 2021. Based on MLR findings, the primary factors influencing mortality costs were the age-standardized CVD death rate, gross domestic product (GDP) per capita, and population age structure.</div></div><div><h3>Conclusions</h3><div>Our results underscore the importance of the growing global mortality costs from CVD associated with non-optimal temperatures. The findings should serve to alert the global community regarding the urgent need to develop policies that aim to protect the public, particularly in regions with the highest costs and aging populations.</div></div>","PeriodicalId":308,"journal":{"name":"Environment International","volume":"202 ","pages":"Article 109693"},"PeriodicalIF":10.3,"publicationDate":"2025-07-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144652192","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Temporal trends of antibiotic resistance in culturable bacteria reveal the role of potential pathogens as pioneering carriers and resistance accumulators 可培养细菌中抗生素耐药性的时间趋势揭示了潜在病原体作为先锋携带者和耐药性积累者的作用
IF 11.8 1区 环境科学与生态学
Environment International Pub Date : 2025-07-18 DOI: 10.1016/j.envint.2025.109692
Biyi Zhao, Wei Chen, Yanxia Ren, Liping Dai, Chaohui Tang, Xian Wang, Lingjie Xie, Yahao Huang, Yong Xiao
{"title":"Temporal trends of antibiotic resistance in culturable bacteria reveal the role of potential pathogens as pioneering carriers and resistance accumulators","authors":"Biyi Zhao, Wei Chen, Yanxia Ren, Liping Dai, Chaohui Tang, Xian Wang, Lingjie Xie, Yahao Huang, Yong Xiao","doi":"10.1016/j.envint.2025.109692","DOIUrl":"https://doi.org/10.1016/j.envint.2025.109692","url":null,"abstract":"Understanding the occurrence and temporal trends of antibiotic resistance genes (ARGs) within bacteria is crucial for controlling and predicting the proliferation of antibiotic-resistant bacteria. However, gaps remain in understanding the long-term trends across different bacterial species and in assessing related health risks. We collected 22,360 bacterial complete genome sequences with collection time and compiled a temporal dataset of ARGs in culturable bacteria. Our results revealed the widespread presence of ARGs among culturable bacterial species, with potential pathogens carrying significantly more ARGs than non-pathogenic species. Temporal trend analysis revealed that only 11.0 % of bacterial species experienced an increase of more than one unit in ARG quantity and diversity over one century, with 83.3 % of them being potential pathogenic species. The temporal accumulation of ARGs in many potential pathogenic species is influenced by the abundance of mobile genetic elements, with several species also exhibiting temporal accumulation of plasmid-borne ARGs. Notably, <em>Shigella flexneri</em> and <em>Klebsiella pneumoniae</em> exhibited an accumulation of high-risk ARGs associated with at least five antibiotic types over at least 40 years. Furthermore, the distribution of ARG-carrying strains before the use of antibiotics revealed a wide range of bacterial species and antibiotic types for intrinsic resistance, including some synthetic antibiotics. This work reveals the significant role of potential pathogens in the expansion of antibiotic resistance and highlights the importance of strengthening vigilance against the emergence of novel multidrug-resistant pathogens.","PeriodicalId":308,"journal":{"name":"Environment International","volume":"8 1","pages":""},"PeriodicalIF":11.8,"publicationDate":"2025-07-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144652191","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Wide-scope screening of micropollutants in stormwater ponds within Swedish urban catchments 瑞典城市集水区雨水池中微污染物的大范围筛选
IF 10.3 1区 环境科学与生态学
Environment International Pub Date : 2025-07-17 DOI: 10.1016/j.envint.2025.109691
Alberto Celma , Victoria Eriksson , Oksana Golovko , Karin Wiberg
{"title":"Wide-scope screening of micropollutants in stormwater ponds within Swedish urban catchments","authors":"Alberto Celma ,&nbsp;Victoria Eriksson ,&nbsp;Oksana Golovko ,&nbsp;Karin Wiberg","doi":"10.1016/j.envint.2025.109691","DOIUrl":"10.1016/j.envint.2025.109691","url":null,"abstract":"<div><div>Stormwater refers to the resulting water from precipitation events. In urbanized areas, impervious surfaces result in an increased runoff and, consequently, mobilize pollutants occurring in urban environments to freshwater bodies. Stormwater ponds function as a treatment step of the water before it enters the recipient water body. However, their efficiency to remediate organic micropollutants remains largely unknown. Hence, there is a need to explore the ability of these man-made barriers to remediate organic micropollutants. In this work, we have investigated both influent and effluent water streams from two stormwater ponds during distinct hydrological events to assess their contribution to pollution transport by means of wide-scope screening of organic micropollutants.</div><div>Several chemicals have been detected. The observed differences in the chemical profile in samples from different ponds highlighted that the activities in the catchment area heavily impacted the composition of the stormwater. Unexpectedly, the chemical profiles of the stormwater during dry and rainy periods were found to be comparable. Additionally, increased contamination was detected in effluent stormwater, indicating poor treatment and the potential redissolution of previously retained chemicals, highlighting the need for better treatment and remediation strategies in man-made stormwater ponds to ensure sustainability of recipient water bodies.</div></div>","PeriodicalId":308,"journal":{"name":"Environment International","volume":"202 ","pages":"Article 109691"},"PeriodicalIF":10.3,"publicationDate":"2025-07-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144645364","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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