Environment International最新文献

{"title":"Artificial intelligence technology in environmental research and health: Development and prospects","authors":"Zhuling Guo ,&nbsp;Lei Huang ,&nbsp;Jia Yan ,&nbsp;Hongguo Zhang ,&nbsp;Xue Jia ,&nbsp;Meng Li ,&nbsp;Hao Li","doi":"10.1016/j.envint.2025.109788","DOIUrl":"10.1016/j.envint.2025.109788","url":null,"abstract":"<div><div>As the research in the environmental field continues to delve into deeper mechanisms, the traditional research paradigm has become inadequate. The introduction of artificial intelligence technology has provided a clear definition for the “green technology revolution”. Compared with traditional methods, AI has achieved a significant improvement in computational efficiency in environmental data analysis, reducing decision-making time by more than 60%. This effectively supports the efficient resolution of complex environmental issues. Meanwhile, the rapid leap-forward development of artificial intelligence (AI) technology is giving rise to a green technological revolution in environmental research. Based on this survey and the developing Digital Catalysis Platform, this commentary systematically summarizes the typical applications of AI in five major areas: treatment of water pollution, control of air pollution, disposal of solid waste, remediation of soil, and environmental health. It focuses on analyzing the remarkable effectiveness demonstrated by AI through machine learning (ML) methods. Such effectiveness is shown in aspects like material screening, performance prediction, instant detection, global distribution simulation of pollutants, and the control of human health. Notably, the current large-scale application of AI technology in the environmental field still faces multiple challenges, especially the scarcity of data samples in complex environmental systems. For instance, small-sample models to overfit, and the uneven geographical coverage of observational data in global pollutant distribution prediction. They all urgently need to be solved. In response to the above-mentioned bottlenecks, this study proposes corresponding solutions. As the technological bottlenecks are gradually overcome, AI is expected to become the core driving force for promoting environmentally sustainable development and contribute to the achievement of the “dual carbon” goals and the restoration of the global ecosystem.</div></div>","PeriodicalId":308,"journal":{"name":"Environment International","volume":"203 ","pages":"Article 109788"},"PeriodicalIF":9.7,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145043325","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The association between glyphosate use and mosaic loss of chromosome Y in buccal samples among male pesticide applicators in the Agricultural Health Study","authors":"Vicky C. Chang ,&nbsp;Stella Koutros ,&nbsp;Lauren M. Hurwitz ,&nbsp;Weiyin Zhou ,&nbsp;Gabriella Andreotti ,&nbsp;Christine G. Parks ,&nbsp;Dale P. Sandler ,&nbsp;Nathaniel Rothman ,&nbsp;Mitchell J. Machiela ,&nbsp;Laura E. Beane Freeman ,&nbsp;Jonathan N. Hofmann ,&nbsp;Sonja I. Berndt","doi":"10.1016/j.envint.2025.109755","DOIUrl":"10.1016/j.envint.2025.109755","url":null,"abstract":"<div><div>Glyphosate-based herbicides are the most widely applied pesticides worldwide and have been implicated in the development of certain hematologic malignancies; however, the underlying biological mechanisms are not well-understood. High lifetime use of glyphosate-based herbicides, hereafter referred to as glyphosate, was previously associated with mosaic loss of chromosome Y (mLOY), a biomarker of genomic instability potentially linked to cancer and immune dysregulation, in circulating blood of male farmers from a subcohort of the Agricultural Health Study (AHS). Here, we further investigated the association between glyphosate use and mLOY using buccal-derived DNA among 1,868 male pesticide applicators in an independent AHS study. We detected mLOY using genotyping array intensity data in the male-specific region of the Y chromosome. Information on cumulative lifetime use of glyphosate was derived from questionnaires. Logistic regression analyses were used to estimate odds ratios (ORs) and 95 % confidence intervals (CIs) for the associations of glyphosate use with overall mLOY and mLOY affecting a high cell fraction (≥ median), adjusted for potential confounders. Overall, mLOY was detected in buccal samples of 298 (16 %) pesticide applicators. High intensity-weighted lifetime days of glyphosate use was associated with overall mLOY (OR_{highest vs. lowest quartile of glyphosate use} = 1.54; 95 % CI: 1.01, 2.37), although the exposure–response trend was not statistically significant (<em>P</em>_trend = 0.40). For mLOY affecting a high fraction of cells, positive associations were observed for both high lifetime days (OR_{highest vs. lowest quartile of glyphosate use} = 1.76; 95 % CI: 1.04, 2.99; <em>P</em>_trend = 0.06) and high intensity-weighted lifetime days (OR_{highest vs. lowest quartile of glyphosate use} = 2.02; 95 % CI: 1.12, 3.64; <em>P</em>_trend = 0.16). Together, these findings support previous evidence linking glyphosate and mLOY and help inform our understanding of the biological impact of glyphosate on human health and its potential role in carcinogenesis.</div></div>","PeriodicalId":308,"journal":{"name":"Environment International","volume":"203 ","pages":"Article 109755"},"PeriodicalIF":9.7,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144919093","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Associations of urinary metabolite concentrations of phthalates and their alternatives with reproductive outcomes among women receiving in vitro fertilization: A repeated measurement analysis","authors":"Xi Qian ,&nbsp;Xiao Luo ,&nbsp;Yalin Duan ,&nbsp;Li Luo ,&nbsp;Ruijia Li ,&nbsp;Qi Zhang ,&nbsp;Xiaodong Zhang ,&nbsp;Jun Shuai ,&nbsp;Juxiao Li ,&nbsp;Guoning Huang ,&nbsp;Yanjian Wan","doi":"10.1016/j.envint.2025.109767","DOIUrl":"10.1016/j.envint.2025.109767","url":null,"abstract":"<div><h3>Background</h3><div>Studies suggest that phthalates (PAEs) may disrupt female reproductive health, but few have explored repeated measurements of PAE and their alternative exposure and their joint impact on reproductive outcomes.</div></div><div><h3>Objectives</h3><div>To evaluate the associations of repeatedly measured urinary levels of PAE and their alternative metabolites with reproductive outcomes in women receiving <em>in vitro</em> fertilization (IVF).</div></div><div><h3>Methods</h3><div>This study included 704 women undergoing IVF between February and October 2023 in Chongqing, China. Concentrations of 23 PAE and PAE alternative metabolites were determined in three urine samples of each participant collected at the IVF treatment appointment (visit 1) and during ovarian stimulation (visits 2 and 3). IVF outcomes were obtained from electronic medical records. Generalized linear models, generalized estimating equations, and quantile g computation (QGC) were applied to evaluate the relationships of individual metabolites and the mixture with the IVF outcomes.</div></div><div><h3>Results</h3><div>Health risk assessment indicated that 19.7 % of the participants had dibutyl phthalate exposure levels exceeding the safety threshold. Urinary concentrations of mono-(6-oxo-2-propylheptyl) phthalate [a metabolite of di-(2-propylheptyl) phthalate (DPHP)] and sum concentrations of DPHP metabolites (ΣDPHP) were related to decreased probability of good-quality embryos on day 3 (percent differences in each interquartile ratio-fold increase of the analyte concentrations ranged from −14.0 % to −15.2 %). These associations were more prominent during ovarian stimulation. QGC analyses also showed a negative association between the mixture and the probability of day 3 good-quality embryos, with ∑DPHP contributing the most.</div></div><div><h3>Conclusions</h3><div>Exposure to DPHP may impair embryo quality in women receiving IVF. The ovarian stimulation stage seems to be a sensitive period. Additional studies are needed to validate these results.</div></div>","PeriodicalId":308,"journal":{"name":"Environment International","volume":"203 ","pages":"Article 109767"},"PeriodicalIF":9.7,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144928024","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The effect of polychlorinated biphenyls on type 2 diabetes risk is mediated via DNA methylation","authors":"Noora Kartiosuo ,&nbsp;Kari Auranen ,&nbsp;Toby Mansell ,&nbsp;Boris Novakovic ,&nbsp;Jaakko Nevalainen ,&nbsp;Katja Pahkala ,&nbsp;Suvi Rovio ,&nbsp;Juha Mykkänen ,&nbsp;Jorma Viikari ,&nbsp;Markus Juonala ,&nbsp;Panu Rantakokko ,&nbsp;Hannu Kiviranta ,&nbsp;Jari Kaikkonen ,&nbsp;Terho Lehtimäki ,&nbsp;Emma Raitoharju ,&nbsp;Pashupati P. Mishra ,&nbsp;Mika Kähönen ,&nbsp;Anne-Louise Ponsonby ,&nbsp;Sam Tanner ,&nbsp;David Burgner ,&nbsp;Richard Saffery","doi":"10.1016/j.envint.2025.109779","DOIUrl":"10.1016/j.envint.2025.109779","url":null,"abstract":"<div><div>Polychlorinated biphenyls (PCBs) have been identified as diabetogens and potential epigenetic regulators. Epigenetic variation is implicated in the pathogenesis of type 2 diabetes (T2D) and is therefore a potential mechanism linking PCB exposure and T2D. We here investigate the effect of PCB exposure on T2D risk and the extent to which this is mediated via DNA methylation (DNAm) using two epigenome-wide association studies and mediation analysis.</div><div>Exposure to PCBs, especially congeners 74, 99, 118, 138 and 183, increased the risk of T2D (range of ORs 1.38–1.54). Five CpG sites were identified as potential mediators. Together, methylation at these sites was estimated to mediate 40 % (95 % CI: 20, 60 %) of the effect of PCBs on T2D. The strongest evidence was obtained for cg00574958, located in the first intron of the <em>CPT1A</em> gene.</div><div>This study is among the largest to date assessing the link between PCBs and T2D, and the first to investigate the mediation by DNAm. The evidence for methylation at cg00574958 as a mediator of the PCB–T2D relationship supports the widely-replicated link of <em>CPT1A</em> DNA methylation to a range of metabolic phenotypes including obesity, dyslipidemia and T2D and indicates a possible future target for epigenetic intervention.</div></div>","PeriodicalId":308,"journal":{"name":"Environment International","volume":"203 ","pages":"Article 109779"},"PeriodicalIF":9.7,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144983359","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Corrigendum to “Environmental contaminants, heavy metals, and essential elements in Norwegian children and adolescents: Data from the Norwegian environmental biobank”. [Environ. Int. 202 (2025) 109633]","authors":"Mari Mohn Paulsen ,&nbsp;Nina Iszatt ,&nbsp;Amrit Kaur Sakhi ,&nbsp;Mahin Karimi ,&nbsp;Sharon Lynn Broadwell ,&nbsp;Eleni Papadopoulou ,&nbsp;Helle Margrete Meltzer ,&nbsp;Berit Granum ,&nbsp;Anne Lise Brantsæter ,&nbsp;Cathrine Thomsen ,&nbsp;Line Småstuen Haug","doi":"10.1016/j.envint.2025.109765","DOIUrl":"10.1016/j.envint.2025.109765","url":null,"abstract":"","PeriodicalId":308,"journal":{"name":"Environment International","volume":"203 ","pages":"Article 109765"},"PeriodicalIF":9.7,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144995321","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Compound drought and heatwave events and childhood diarrhea: current impacts and future risk in low- and middle-income countries","authors":"Wenhao Yu ,&nbsp;Mingxiao Guo ,&nbsp;Guoao Li ,&nbsp;Wen Li ,&nbsp;Yanwen Cao ,&nbsp;Kejia Hu ,&nbsp;Haitao Wang ,&nbsp;Wei Ma ,&nbsp;Qi Zhao ,&nbsp;Lixiang Li ,&nbsp;Jie Yan","doi":"10.1016/j.envint.2025.109792","DOIUrl":"10.1016/j.envint.2025.109792","url":null,"abstract":"<div><h3>Background</h3><div>The risk of childhood diarrhea related to compound drought and heatwave (CDHW) remain unclear at present and in the future under climate change scenarios.</div></div><div><h3>Methods</h3><div>We used information on diarrhea prevalence from the Demographic and Health Surveys. Three indicators considering heatwave frequency (HWF), intensity (HWEMD), and cumulative heat (CH) were used. CDHW was defined as drought and heatwave occurred simultaneously. A modified Poisson regression model was employed to estimate the association between CDHW and diarrhea. Then the association was used to project the excess risk of CDHW-related childhood diarrhea by climate zones and regions under different climate scenarios.</div></div><div><h3>Results</h3><div>A total of 64,429 children under five years were included. The relative risk (RR) of CDHWs (e.g., compound severe HWF and severe drought; RR = 1.392, 95 %CI: 1.247–1.553) were significantly higher than heatwave alone (e.g., severe HWF only; RR = 1.150, 95 %CI: 1.044–1.268). The effect of severe CDHWs disappeared from subgroups with low to high Water, sanitation and hygiene (WASH) scores. The average excess risk (ER) per hot season attributed to compound drought and HWF increased by 16.4–84.8 % during 2021–2100 under various climate change scenarios. Future CDHW-related ER of childhood diarrhea varied by climate zones and geographic regions.</div></div><div><h3>Conclusion</h3><div>There was a stronger association between CDHW and diarrhea risk than that of heatwave alone, while good WASH had a potential protective effect. Our findings highlight the need of integrated public health and climate adaptation strategies to address the escalating burden of childhood diarrhea associated with compound climate extremes.</div></div>","PeriodicalId":308,"journal":{"name":"Environment International","volume":"203 ","pages":"Article 109792"},"PeriodicalIF":9.7,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145067847","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Complex interplay between composted manure application, metal contamination, and antibiotic resistance genes profile under tropical field conditions","authors":"Julio Flavio Osti ,&nbsp;Rafael Marques Pereira Leal ,&nbsp;Adijailton José de Souza ,&nbsp;Luiz Gustavo Paulon Rezende ,&nbsp;Douglas Gomes Viana ,&nbsp;Fernando Dini Andreote ,&nbsp;Rafael Santana Mendonça ,&nbsp;Adriano Jakelaitis ,&nbsp;Jussara Borges Regitano","doi":"10.1016/j.envint.2025.109783","DOIUrl":"10.1016/j.envint.2025.109783","url":null,"abstract":"<div><div>Manure applications in agricultural soils are a major driver of antibiotic resistance gene (ARG) dissemination, yet long-term effects of composted manure applications under tropical real field conditions remain unclear. This study assessed how successive composted manure applications influence soil physicochemical attributes, bacteriome and resistome profiles in the Brazilian Cerrado, including one site with naturally high heavy metal content. Across all sites, multidrug resistance genes were most abundant, followed by macrolide-lincosamide-streptogramin (MLS), tetracycline, β-lactam and glycopeptides resistance, aligning with predominance of Actinomycetota and Pseudomonadota as key ARG hosts. Manure increased soil pH and available phosphorus (P), with pH significantly shaping bacterial communities and pH and P the resistome in uncontaminated sites (2 and 3). However, in the metal-rich site (1), Cu was the dominant driver. Manure increased ARG richness and changed resistome structure but did not affect clinically relevant genes or resistome diversity. Metal resistance genes (MRGs), particularly for Cu and Zn, strongly influenced resistome dynamics, highlighting co-selection. Integrons integrase genes (<em>intl</em>) abundance increased in metal-depleted but not in metal-rich soils. While composting appears to mitigate ARG spread, particularly for clinically relevant genes, the high antibiotic use in livestock, large manure volumes, and potential for ARG persistence in tropical soils highlight the need for further research on manure treatment strategies and ARG fate in these environments.</div><div>Environmental Implication.</div><div>Our study highlights the environmental risks of antibiotic resistance gene (ARG) dissemination in tropical agricultural soils, emphasizing the role of manure application and heavy metal contamination in shaping soil resistome. While composted manure increased bacterial diversity and ARG richness, it did not significantly impact clinically relevant genes and resistome diversity, suggesting that composting may help mitigate ARG spread but does not eliminate it. Metals were the dominant drivers of ARG selection in the contaminated site, underscoring the role of co-selection mechanisms in maintaining resistance. However, manure applications increased integrons abundance, raising concerns about horizontal gene transfer and potential ARG proliferation into pathogens. These findings stress the urgent need for improved manure management policies in Brazil, where high antibiotic use in livestock and large manure volumes pose significant environmental and public health risks. Developing sustainable manure treatment strategies and monitoring ARG persistence are essential to limit antibiotic resistance proliferation in tropical agricultural ecosystems.</div></div>","PeriodicalId":308,"journal":{"name":"Environment International","volume":"203 ","pages":"Article 109783"},"PeriodicalIF":9.7,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145003491","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Multi-omics investigation of Bisphenol A in gastrointestinal carcinogenesis: a network toxicology and molecular docking approach","authors":"Jiayun Guan ,&nbsp;Kaican Yang ,&nbsp;Tianyang Chen ,&nbsp;Zewei Li ,&nbsp;Ya Gao ,&nbsp;Yue Huang ,&nbsp;Rui Zhou ,&nbsp;Zhenhua Huang ,&nbsp;Yangfeng Du ,&nbsp;Ting Li ,&nbsp;Baoxiong Zhuang ,&nbsp;Xiaoxiang Rong","doi":"10.1016/j.envint.2025.109785","DOIUrl":"10.1016/j.envint.2025.109785","url":null,"abstract":"<div><div>Our study aims to systematically investigate the potential carcinogenic mechanisms of bisphenol A (BPA) in three gastrointestinal tumors: intrahepatic cholangiocarcinoma (ICC), colorectal cancer (CRC), and esophageal cancer. By systematically integrating multi-omics databases, including transcriptomics and single-cell transcriptomics, we identified overlapping targets between BPA-associated molecules and tumor-related genes. Functional enrichment revealed that these targets converge on key oncogenic pathways, including<!--> <!-->cellular metabolic reprogramming (particularly glycolysis), tumor microenvironment remodeling via cancer-associated fibroblast (CAF) activation, and dysregulation of cell cycle progression. Molecular docking verified strong binding affinity between BPA and key targets. Survival analysis linked GAPDH and HSP90AA1 in ICC, CDKN1A, CEBPB, and EGR1 in CRC, and DCN and CXCL12 in esophageal cancer to poor survival rates, highlighting their potential as prognostic biomarkers. Our findings demonstrate that BPA promotes gastrointestinal carcinogenesis<!--> <!-->through disrupting energy metabolism, activating CAFs to remodel the tumor microenvironment, and enhancing cancer cell proliferation. This multi-level evidence advances the risk assessment of BPA and identifies potential targets for prevention and therapy of BPA-linked gastrointestinal cancers.</div><div>Environmental Implication.</div><div>In addition to well-documented role in promoting endocrine-related diseases, the mechanisms by which hazardous compound bisphenol A (BPA) contributes to other pathological conditions must not be overlooked. Through systematic integration of biological evidence chains, this study revealed BPA’s triple carcinogenic mechanism involving interference with cell cycle checkpoints, remodeling of tumor microenvironment stroma, and disruption of epigenetic regulation, thereby providing a novel target system for preventing environmental toxicant-induced gastrointestinal tumors.</div></div>","PeriodicalId":308,"journal":{"name":"Environment International","volume":"203 ","pages":"Article 109785"},"PeriodicalIF":9.7,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145009510","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Integrated network toxicology, machine learning, molecular docking and experimental validation to elucidate mechanism of polyethylene terephthalate microplastics inducing periodontitis","authors":"Yaoling Han ,&nbsp;Zhengchuan Zhang ,&nbsp;Zijun Wang ,&nbsp;Yiming Li ,&nbsp;Guanhui Chen ,&nbsp;Chen Yi ,&nbsp;Rui Wang ,&nbsp;Dongsheng Yu ,&nbsp;Yi He","doi":"10.1016/j.envint.2025.109784","DOIUrl":"10.1016/j.envint.2025.109784","url":null,"abstract":"<div><div>Growing evidence highlights the health risks of micro-plastics (MPs) exposure, with reported accumulations in enclosed anatomical sites such as the heart, placenta, and circulatory system. However, the role of MPs in periodontitis remains unexplored. This study employed bioinformatics, network toxicology, machine learning, molecular docking, and experimental approaches to explore the effects and underlying mechanisms of polyethylene terephthalate microplastics (PET-MPs) induced periodontitis. Multi-database screening, including GEO, ChEMBL, STITCH, GeneCards, OMIM, identified 23 candidate targets linked to PET-MPs exposure. Furthermore, we used STRING, Cytoscape software and machine learning approaches to identified 13 core targets. Gene Ontology (GO), Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway enrichment and immune cell infiltration analyses revealed that PET-MPs influence immune-related pathways, such as C-type lectin receptor signaling, VEGF receptor signaling, and TNF signaling. Molecular docking revealed high-affinity binding interactions between PET-MPs and core targets, implicating direct interference with cellular processes. Experimental assays using gingival fibroblasts (GFs) exposed to PET-MPs showed dose-dependent cytotoxicity oxidative stress induction, and pro-inflammatory activation. PET-MPs upregulated inflammation-related markers including Caspase 3, KDR, PIM2, PTGS2, MTOR, MAPK14; while downregulating AKT1 and ALPL. These findings establish a mechanistic framework linking PET-MPs exposure to periodontitis progression via redox-inflammatory crosstalk, offering novel insight into the potential pathogenesis of microplastics on periodontitis.</div></div>","PeriodicalId":308,"journal":{"name":"Environment International","volume":"203 ","pages":"Article 109784"},"PeriodicalIF":9.7,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145025753","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Systematic reviews and meta-analyses for the WHO assessment of health effects of exposure to radiofrequency electromagnetic fields, an introduction","authors":"Jos Verbeek ,&nbsp;Hajo Zeeb ,&nbsp;Emilie van Deventer ,&nbsp;Sharea Ijaz ,&nbsp;Jean-François Doré ,&nbsp;Sarah Driessen ,&nbsp;Nicolas Roth ,&nbsp;Paul Whaley","doi":"10.1016/j.envint.2025.109751","DOIUrl":"10.1016/j.envint.2025.109751","url":null,"abstract":"","PeriodicalId":308,"journal":{"name":"Environment International","volume":"203 ","pages":"Article 109751"},"PeriodicalIF":9.7,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144910897","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}