参加自愿全氟烷基和多氟烷基物质减少治疗方案的消防员血清全氟辛烷磺酸和全氟己烷磺酸浓度的变化

IF 9.7 1区环境科学与生态学 Q1 ENVIRONMENTAL SCIENCES

Environment International Pub Date : 2025-06-16 DOI:10.1016/j.envint.2025.109609

Ian Delaere , Kerry Harris , Sharyn Gaskin , Yonatal Tefera , Krystle Mitchell , David Springer , Simon Mills

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引用次数: 0

摘要

2018/2019年，一项自愿基线生物监测调查（n = 916）发现，一个消防站的消防员血清中全氟辛烷磺酸（PFOS）和全氟己烷磺酸（PFHxS）浓度大幅升高。南澳大利亚大都会消防局（SAMFS）发起了一项自愿治疗计划（VTP）来解决这些暴露的影响（参与者n = 19）。在VTP结束时，独立于VTP对去识别和编码的血清PFOS和PFHxS浓度表进行回顾性分析。目的：本研究报告血清PFOS和PFHxS浓度的纵向变化，并将接受VTP治疗的参与者与未寻求治疗的观察组进行比较。方法数据集分为治疗组（n = 19）和观察组（n = 9）。治疗组进一步细分为三个亚组：(1)血浆捐献组（n = 2），(2)给胆甾胺组（n = 12），(3)血浆捐献和给胆甾胺组（n = 5）。重复取样确定了受试者血清中PFOS和PFHxS的最高和最低浓度。计算只包括血清全氟辛烷磺酸和PFHxS浓度下降的参与者的数据。用一室一级消除动力学估计表观半衰期。该研究没有进行统计比较；结论是根据目测得出的。结果治疗组全氟辛烷磺酸（PFOS）血药浓度的平均变化：最大下降162 ng/mL，年下降41 %，半衰期1.2 年；PFHxS：最大减少37 ng/mL，年减少32 %，半衰期2.5 年)与观察组比较(PFOS：最大减少41 ng/mL，年减少12 %，半衰期7.3 年；PFHxS：最大减少6 ng/mL，年减少10 %，半衰期9.4 年)。结论本研究表明，接受治疗的受试者血清中PFOS和PFHxS的清除率高于观察组。

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Changes in serum perfluorooctane sulfonic acid and perfluorohexane sulfonic acid concentrations in firefighters accessing a voluntary perfluoroalkyl and polyfluoroalkyl substances reduction treatment program

Background

In 2018/2019 a voluntary baseline biomonitoring survey (n = 916) identified firefighters at a fire station with substantially elevated serum perfluorooctane sulfonic acid (PFOS) and perfluorohexane sulfonic acid (PFHxS) concentrations. The South Australian Metropolitan Fire Service (SAMFS) initiated a voluntary treatment program (VTP) to address the impact of these exposures (participants n = 19). At the conclusion of the VTP, a retrospective analysis of a de-identified and coded serum PFOS and PFHxS concentration spreadsheet was conducted independently of the VTP.

Objective

This study reports longitudinal changes in serum PFOS and PFHxS concentrations and compares participants accessing the VTP with an observational group that did not seek treatment.

Methods

The dataset included a treatment group (n = 19) and an observation group (n = 9). The treatment group was further subdivided into three subgroups: (1) plasma donation (n = 2), (2) cholestyramine administration (n = 12), and (3) a combination of plasma donation and cholestyramine administration (n = 5). Repeat samples identified participants’ maximum and minimum serum PFOS and PFHxS concentrations. The calculations only included data from participants whose serum PFOS and PFHxS concentrations decreased. Apparent half-lives were estimated using one-compartment first-order elimination kinetics. The study did not conduct statistical comparisons; conclusions were drawn based on visual observations.

Results

The average change in serum concentration for the treatment group (PFOS: maximum decrease of 162 ng/mL, annual decrease of 41 %, with a half-life of 1.2 years; PFHxS: maximum decrease of 37 ng/mL, annual decrease of 32 %, with a half-life of 2.5 years) was compared with the observation group (PFOS: maximum decrease of 41 ng/mL, annual decrease of 12 %, with a half-life of 7.3 years; PFHxS: maximum decrease of 6 ng/mL, annual decrease of 10 %, with a half-life of 9.4 years).

Conclusion

This study shows that participants who received treatment eliminated PFOS and PFHxS from their serum at a greater rate than the observation group.

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来源期刊

Environment International 环境科学-环境科学

CiteScore

21.90

自引率

3.40%

发文量

734

审稿时长

2.8 months

期刊介绍： Environmental Health publishes manuscripts focusing on critical aspects of environmental and occupational medicine, including studies in toxicology and epidemiology, to illuminate the human health implications of exposure to environmental hazards. The journal adopts an open-access model and practices open peer review. It caters to scientists and practitioners across all environmental science domains, directly or indirectly impacting human health and well-being. With a commitment to enhancing the prevention of environmentally-related health risks, Environmental Health serves as a public health journal for the community and scientists engaged in matters of public health significance concerning the environment.