Environment International最新文献

{"title":"Environmental heat exposure triggers neuronal apoptosis via NCOA4-mediated ferritinophagy","authors":"Fei Wang,&nbsp;Jingsi Meng,&nbsp;Shaomeng Kang,&nbsp;Jiaqian Gao,&nbsp;Yan-Zhong Chang","doi":"10.1016/j.envint.2026.110364","DOIUrl":"10.1016/j.envint.2026.110364","url":null,"abstract":"<div><div>Global warming increases the frequency and intensity of environmental heat exposure, posing a growing threat to public health. While heat-related mortality is well-documented, the neurological consequences of heat exposure remain poorly characterized at the mechanistic level. Here, by integrating epidemiological data from the US National Health and Nutrition Examination Survey (NHANES), clinical transcriptomic data from heatstroke patients, and experimental models, we identified intracellular iron dyshomeostasis as a critical driver of heat-induced neuronal injury. Mechanistically, severe heat exposure activates the extracellular signal-regulated kinase pathway, which stabilizes nuclear receptor coactivator 4 by suppressing its ubiquitination. The subsequent accumulation of Nuclear receptor coactivator 4 (NCOA4) recruits microtubule-associated protein 1 light chain 3B (LC3B) to drive excessive ferritin degradation via ferritinophagy. This process expands the labile iron pool (LIP) and triggers reactive oxygen species (ROS) production, which primarily executes neuronal apoptosis. Notably, pharmacological intervention with the iron chelator deferasirox (DFX) effectively alleviated heat-induced neurological damage by disrupting this iron-dependent cascade. Our findings establish the ERK/NCOA4/LC3B-mediated ferritinophagy pathway as a promising therapeutic target, providing a translational foundation for interventions against heat-induced neurological injuries.</div></div>","PeriodicalId":308,"journal":{"name":"Environment International","volume":"213 ","pages":"Article 110364"},"PeriodicalIF":10.2,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148256603","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Corrigendum to “Bisphenol-A from environment macro-circulation to human micro-circulation: a novel link to abdominal aortic aneurysm” [Environ. Int. 210 (2026) 110217]","authors":"Shuli Zhang ,&nbsp;Feilong Zhang ,&nbsp;Dandan Liu ,&nbsp;Xiaozeng Wang ,&nbsp;Yajing Guo ,&nbsp;Nan Zhang ,&nbsp;Chunge Dang ,&nbsp;Ruichen Wang","doi":"10.1016/j.envint.2026.110267","DOIUrl":"10.1016/j.envint.2026.110267","url":null,"abstract":"","PeriodicalId":308,"journal":{"name":"Environment International","volume":"212 ","pages":"Article 110267"},"PeriodicalIF":9.7,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147756179","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Atmospheric aging of tire rubber antioxidants forms complex mixtures that trigger inflammation in human macrophages","authors":"Chao Peng ,&nbsp;John Liggio ,&nbsp;Samar G. Moussa ,&nbsp;Yitian Tang ,&nbsp;Cassandra Johannessen ,&nbsp;Xianming Zhang ,&nbsp;Zhizhen Zhang ,&nbsp;Li Li ,&nbsp;Tom Harner ,&nbsp;Amandeep Saini ,&nbsp;Hayley Hung ,&nbsp;Jeremy Wentzell ,&nbsp;Michael J. Wheeler ,&nbsp;Ewa Dabek-Zlotorzynska ,&nbsp;Mahmoud Yassine ,&nbsp;Qifan Liu ,&nbsp;Mingjin Tang ,&nbsp;Zoey Friel-Bartlett ,&nbsp;Ali A. Abdul-Sater","doi":"10.1016/j.envint.2026.110307","DOIUrl":"10.1016/j.envint.2026.110307","url":null,"abstract":"<div><div>Antioxidants added to tires to prevent degradation have recently been recognized as emerging environmental contaminants. While their acute aquatic toxicity has raised concern, these compounds are also emitted to the atmosphere and can be associated with particulate matter (PM). On PM they can react heterogeneously with oxidants, producing a range of transformation products (TPs) with unknown impacts to human health via inhalation. Here, we show through laboratory experiments that many previously unrecognized TPs are formed in complex mixtures from both OH radical and ozone heterogeneous reactions of N-(1,3-dimethylbutyl)-N’-phenyl-p-phenylenediamine (6PPD) and N,N’-diphenyl-1,4-phenylenediamine (DPPD). In the presence of nitrogen oxides, 13 TPs incorporated additional nitrogen atoms in the form of potentially toxic nitrosamines and nitramines. Overall, &gt;150 TPs were detected in oxidation experiments, with &gt; 88 also identified in ambient near-road and urban PM samples. When tested in human macrophages, these TP mixtures induced potent inflammatory responses and rapid cell death. The effects consistently exceeded those caused by the parent antioxidants and by the single quinone compound (6PPD-Q), commonly assumed to trigger toxicity, even at total mixture concentrations comparable to those recently measured in human blood serum. These findings suggest that atmospheric processing of tire-wear chemicals produces PM-associated transformation products, which could potentially contribute to an elevated risk of inflammation-driven diseases near roads. The work highlights the importance of evaluating atmospherically derived tire-wear TPs as dynamic, interactive mixtures rather than isolated compounds, particularly as electric vehicles with higher tire wear emissions become more prevalent.</div></div>","PeriodicalId":308,"journal":{"name":"Environment International","volume":"212 ","pages":"Article 110307"},"PeriodicalIF":9.7,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148025411","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Corrigendum to “Towards safe plastic recycling: A novel framework for identifying chemicals of concern in plastic waste” [Environ. Int., 209 (2026) 110177]","authors":"Golnoush Abbasi ,&nbsp;Miguel Las Heras Hernández ,&nbsp;Émilien Bourgé ,&nbsp;Mikael Harju ,&nbsp;Marina Jennifer Hauser ,&nbsp;Vladimir Nikiforov","doi":"10.1016/j.envint.2026.110265","DOIUrl":"10.1016/j.envint.2026.110265","url":null,"abstract":"","PeriodicalId":308,"journal":{"name":"Environment International","volume":"212 ","pages":"Article 110265"},"PeriodicalIF":9.7,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147758624","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Corrigendum to “Street-view-measured greenspace components and childhood myopia: A population-based cross-sectional and prospective cohort study” [Environ. Int. 210 (2026) 110230]","authors":"Yingan Li ,&nbsp;Yuzhou Zhang ,&nbsp;Charlene C. Yim ,&nbsp;Lixian Su ,&nbsp;Ka Wai Kam ,&nbsp;Poemen Chan ,&nbsp;Patrick Ip ,&nbsp;Wei Zhang ,&nbsp;Alvin Young ,&nbsp;Chi Pui Pang ,&nbsp;Clement C. Tham ,&nbsp;Li Jia Chen ,&nbsp;Mei Po Kwan ,&nbsp;Jason C. Yam","doi":"10.1016/j.envint.2026.110266","DOIUrl":"10.1016/j.envint.2026.110266","url":null,"abstract":"","PeriodicalId":308,"journal":{"name":"Environment International","volume":"212 ","pages":"Article 110266"},"PeriodicalIF":9.7,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147739208","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Positive body image is a pathway between nature contact and life satisfaction across 58 nations","authors":"Viren Swami ,&nbsp;Martin Voracek ,&nbsp;Stefan Stieger ,&nbsp;Toivo Aavik ,&nbsp;Hamed Abdollahpour Ranjbar ,&nbsp;Sulaiman Olanrewaju Adebayo ,&nbsp;Reza Afhami ,&nbsp;Oli Ahmed ,&nbsp;Annie Aimé ,&nbsp;Marwan Akel ,&nbsp;Hussam Al Halbusi ,&nbsp;George Alexias ,&nbsp;Khawla F. Ali ,&nbsp;Nursel AlpDal ,&nbsp;Anas B. Alsalhani ,&nbsp;Sara ÁlvarezSolas ,&nbsp;Ana Carolina Soares Amaral ,&nbsp;Sonny Andrianto ,&nbsp;Trefor Aspden ,&nbsp;Marios Argyrides ,&nbsp;Ulrich S. Tran","doi":"10.1016/j.envint.2026.110277","DOIUrl":"10.1016/j.envint.2026.110277","url":null,"abstract":"<div><div>Time spent in nature benefits human mental and physical well-being. However, much of the variance in outcomes of nature contact remains unexplained, suggesting that new mechanistic pathways need to be considered. Here, we tested a novel conceptual model linking nature contact with life satisfaction via pathways involving positive experiences of living in and experiencing the world through the physical self. Using data from the Body Image in Nature Survey (BINS; <em>N</em> = 50,363), representing respondents from 58 nations and speaking 36 different languages, we find that nature contact is associated with greater self-compassion and greater perceived restoration in nature, which in turn are associated with more positive body image. In addition, more positive body image is associated with greater life satisfaction. These associations were robust to sensitivity tests, generalised to all gender identities and age groups, and held individually in almost all national groups and languages. Although replications are needed, we propose that the materialities of natural environments help to link bodily experiences to the production and experience of well-being, a process that is largely stable across national groups.</div></div>","PeriodicalId":308,"journal":{"name":"Environment International","volume":"212 ","pages":"Article 110277"},"PeriodicalIF":9.7,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147939810","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sustaining low-cost PM2.5 monitoring networks in South-Asian Countries: technical challenges and solutions","authors":"Talha Saeed ,&nbsp;Muhammad Mahad Khaliq ,&nbsp;Michael Howard Bergin ,&nbsp;Prakash V. Bhave ,&nbsp;Noora Khaleel ,&nbsp;Enna Mool ,&nbsp;Mahesh Senarathna ,&nbsp;Shahid Uz Zaman ,&nbsp;Shatabdi Roy ,&nbsp;Abdus Salam ,&nbsp;Jas Raj Subba ,&nbsp;Suhaib Malik ,&nbsp;Darren Y. Wu ,&nbsp;Muhammad Fahim Khokhar","doi":"10.1016/j.envint.2026.110275","DOIUrl":"10.1016/j.envint.2026.110275","url":null,"abstract":"<div><div>The need to monitor South Asia’s air quality stems from its significant negative effects on human and environmental health. Traditional, regulatory-grade air quality monitoring systems have proven costly to operate and very difficult to maintain in most South-Asian countries. Low-cost sensor (LCS) networks have been touted as a viable alternative, but the challenges to sustain them have not been evaluated or thoroughly documented. The acceptance of such monitors, specifically by regulatory agencies, across South-Asian countries is still lacking. Lack of acceptance is due to prevailing myths (especially, in the regulatory circles of South-Asian countries) about their accuracy, precision, consistency, dependability, maintenance, and calibration concerns. The present study fills that knowledge gap through a systematic multi-country empirical analysis while also providing evidence-based solutions to enhance the longevity of LCS across diverse operational environments. Specifically, this study describes strategies and maintenance plans for operating large LCS networks of TSI BlueSky (8143) Sensors across several South-Asian countries, with a focus on problems caused by power outages, power surges, weather conditions, and continued exposure to high amounts of dust and pollution. The article provides further support that incorporating LCS networks into the regulatory framework can facilitate the enforcement of environmental regulations and legislation against polluters. The goal is to develop a more reliable and long-lasting air quality monitoring system that will assist regional environmental regulatory authorities in reducing air pollution-related health hazards and consequent socio-economic disruptions.</div></div>","PeriodicalId":308,"journal":{"name":"Environment International","volume":"211 ","pages":"Article 110275"},"PeriodicalIF":9.7,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147756187","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Multi-omics integration identifies PFOS-associated immune signatures in Kawasaki disease","authors":"Jia Quan ,&nbsp;Juxiang Tu ,&nbsp;Dan Li ,&nbsp;Zongli Zhang ,&nbsp;Lisha Xue ,&nbsp;Tao Li ,&nbsp;Shibing Xi","doi":"10.1016/j.envint.2026.110279","DOIUrl":"10.1016/j.envint.2026.110279","url":null,"abstract":"<div><div>Kawasaki disease (KD), also known as mucocutaneous lymph node syndrome (MCLS), remains the leading cause of acquired heart disease in children younger than 5 years; coronary artery lesions (CALs) develop in 20–30% of untreated patients. Although environmental exposures have been implicated, evidence is inconclusive, and systematic analyses linking exposure profiles to KD-associated immune signatures are still lacking. Despite rising global incidence, the etiology remains unclear, and systematic exploration of potential associations between environmental exposure and KD immune signatures is insufficient. This study employed integrated multi-omics analysis to explore potential associations between perfluorooctane sulfonate (PFOS) exposure and KD immune transcriptomic signatures. By intersecting KD transcriptomic signatures with PFOS toxicological targets, we identified 83 candidate genes significantly enriched in immune-inflammatory pathways. Permutation testing demonstrated PFOS-specific enrichment compared with structurally related compounds (enrichment fold = 2.45; <em>P</em> &lt; 0.001). Machine learning combined with SHAP analysis identified four candidate hub genes (ALPL, IL4R, PGD, SLC22A4) showing consistent expression patterns across independent cohorts. Computational molecular simulations predicted potential binding interfaces between PFOS and candidate proteins, with more favorable docking scores compared to non-fluorinated analogs (6.4–8.9 kcal/mol). Single-cell RNA sequencing revealed hub gene expression in CD14/CD16 Mono and CD8⁺ T, which exhibited elevated PFOS response scores. Transcription factor network analysis predicted CEBPB and CDX2 as candidate regulators associated with hub gene expression, with their regulatory activities correlated with PFOS response scores (activity differences and score-dependent monotonic trends; both <em>P</em> &lt; 2.2 × 10⁻¹⁶). These computational findings suggest potentially PFOS-associated transcriptomic signatures in KD, providing candidate targets for subsequent mechanistic validation and epidemiological studies.</div></div>","PeriodicalId":308,"journal":{"name":"Environment International","volume":"211 ","pages":"Article 110279"},"PeriodicalIF":9.7,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147803636","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Systematic review on internal exposure to per- and polyfluoroalkyl substances (PFAS) and risk of ischemic heart diseases","authors":"Moritz L. Bauer ,&nbsp;Cornelia Weikert ,&nbsp;Sven Knüppel ,&nbsp;Bernhard H. Monien ,&nbsp;Klaus Abraham ,&nbsp;Juliane Menzel","doi":"10.1016/j.envint.2026.110278","DOIUrl":"10.1016/j.envint.2026.110278","url":null,"abstract":"<div><div>Per- and polyfluoroalkyl substances (PFAS) may elevate blood lipids, suggesting that PFAS may also target the cardiovascular system. This systematic review aimed to investigate the relationship between internal human exposure to main PFAS, i.e., perfluorooctanoic acid (PFOA), perfluorooctanesulfonic acid (PFOS), perfluorononanoic acid (PFNA), and perfluorohexanesulfonic acid (PFHxS) and ischemic heart diseases (IHD).</div><div>Two systematic literature searches were performed in MEDLINE and EMBASE – most recently on January 8, 2025. Eligible studies analyzed associations between individual blood PFAS exposure and IHD among humans. Risk of bias was assessed using the OHAT Risk of Bias Rating Tool and evidence was synthesized using structured tables and vote counting based on direction of effect, as <em>meta</em>-analyses and dose–response analyses did not provide meaningfully interpretable results.</div><div>The 16 studies included comprised 79,313 participants. Seven studies estimated rate ratios (RR) and nine estimated odds ratios (OR). Associations between PFOA exposure and IHD (RR) were small and exposure levels were heterogeneous. In the vote counting analysis of the association between PFOA exposure and IHD, 82.4% (95%–CI: 56.6%–96.2%) of effect estimates (RR) pointed in the harmful direction (low certainty). A harmful tendency was less pronounced for PFOS and IHD, with 60.0% (95%-CI: 14.7%–94.7%) of RR and 46.4% (95%-CI 27.5%–66.1%) of OR indicating a harmful relationship. For PFHxS, PFNA, and the sum of PFAS, the overall direction of the vote counting results differed between RR and OR (very low or low certainty).</div><div>The relationship between PFAS and IHD remains unclear, so further longitudinal studies investigating dose-dependent effects are required.</div></div>","PeriodicalId":308,"journal":{"name":"Environment International","volume":"211 ","pages":"Article 110278"},"PeriodicalIF":9.7,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147831880","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Neglected but potentially significant emissions of unintentional persistent organic pollutants from primary copper smelting industry","authors":"Yuxiang Sun ,&nbsp;Changzhi Chen ,&nbsp;Qiuting Yang ,&nbsp;Jianghui Yun ,&nbsp;Minghui Zheng ,&nbsp;Guorui Liu","doi":"10.1016/j.envint.2026.110282","DOIUrl":"10.1016/j.envint.2026.110282","url":null,"abstract":"<div><div>Copper smelting is an important source of unintentional persistent organic pollutants (POPs). Yet emission assessment and inventories remain limited by two key field-evidence gaps: (i) scarce measurement-based emission factors (EFs) for primary copper smelting and (ii) a lack of quantitative constraints on fugitive-derived POP releases. In this study, we conduct field measurements at three primary copper smelting plants and compare POP burdens across end-of-pipe stack gas and a secondary-capture stream capturing fugitive-derived gas. For primary copper smelting using an Ausmelt furnace with electrostatic precipitation as the end-of-pipe control, EFs of polychlorinated dibenzo-p-dioxins and dibenzofurans (PCDD/Fs), dioxin-like polychlorinated biphenyls, and polybrominated dibenzo-p-dioxins and dibenzofurans were estimated at 0.03–0.14, 0.004–0.023, and 0.055–0.062 μg TEQ t⁻¹, respectively. In contrast, reported PCDD/F EFs could be as high as 0.65 μg TEQ t⁻¹ for oxygen-enriched side-blown furnace smelting equipped with baghouse filtration. These results indicate that emissions from primary copper smelting warrant attention in regions with concentrated production activity. The secondary-capture stream exhibited comparable POP concentrations to those in end-of-pipe emissions. Fugitive-related pathways could contribute emissions on the same order as end-of-pipe releases. Fugitive releases should be explicitly considered to reduce systematic underestimation in inventories and associated risk assessments.</div></div>","PeriodicalId":308,"journal":{"name":"Environment International","volume":"211 ","pages":"Article 110282"},"PeriodicalIF":9.7,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147831914","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}