Environment International最新文献

{"title":"Chlorogenic acid counteracts mycophenolate mofetil-induced neurotoxicity in zebrafish and PC12 cells: A potential bioremediation strategy for aquatic pharmaceuticals","authors":"Jiao Wu ,&nbsp;Jiao-Jie Guo ,&nbsp;Fang-Chao Tong ,&nbsp;Shuang-Ling Zhang ,&nbsp;Jia-Long Zhang ,&nbsp;Meng-Yao Chen ,&nbsp;Hai-Chuan Yu","doi":"10.1016/j.envint.2025.109771","DOIUrl":"10.1016/j.envint.2025.109771","url":null,"abstract":"<div><div>Pharmaceutical pollution, particularly from immunosuppressants like mycophenolate mofetil (MMF), has emerged as a significant environmental contaminant in aquatic ecosystems, frequently detected in wastewater at concentrations of 0.1–2.5 μg/L with an occurrence rate exceeding 80 %. This study demonstrates that chlorogenic acid (CGA), a plant-derived polyphenol found in coffee, fruits, and medicinal plants, effectively counters MMF-induced neurotoxicity in both zebrafish and neuronal cells. Specifically, CGA significantly protected PC12 cells from H₂O₂-induced damage by promoting cell proliferation, inhibiting apoptosis, and reducing oxidative stress in a dose-dependent manner. Exposure to 1 µM MMF reduced PC12 cell proliferation to 46.1 %, increased ROS 2.8-fold, elevated MDA 4.6-fold, and decreased SOD by 40 %. In zebrafish, motor-neuron axonal length was shortened to 56.6 % of control. Co-treatment with 10 µM CGA restored PC12 proliferation to 74.7 %, normalized ROS and MDA levels, and recovered SOD to 89 %. In zebrafish larvae, 100 µM CGA can extend the MMF-induced shortening of motor neuron axon length from 56.6 % to 89.5 %. Network pharmacology and ESR1 knockdown studies identified estrogen receptor 1 (ESR1) as a critical mediator of CGA’s protective effects, supported by surface plasmon resonance (SPR) data confirming direct binding between CGA and ESR1. Notably, ESR1 silencing mitigated MMF-induced neurotoxicity, restoring PC12 cell proliferation to 64.8 % and zebrafish motor-neuron axonal length to 86 % of control. Our findings not only uncover the previously unrecognized environmental neurotoxicity of MMF but also elucidate CGA’s multimodal protective mechanisms via ESR1 modulation. Furthermore, this work highlights the potential of dietary polyphenols as sustainable, eco-friendly agents for bioremediating pharmaceutical pollutants. By providing mechanistic insights into detoxification strategies, our study advances nature-based solutions for mitigating immunosuppressant contamination in aquatic systems, offering a promising approach to address emerging environmental challenges.</div></div>","PeriodicalId":308,"journal":{"name":"Environment International","volume":"203 ","pages":"Article 109771"},"PeriodicalIF":9.7,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145043324","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Assessing the impact of perfluoroalkyl substances on liver health: a comprehensive study using multi-donor human liver spheroids","authors":"Lucy Golden-Mason ,&nbsp;Matthew P. Salomon ,&nbsp;Chikako Matsuba ,&nbsp;Yufen Wang ,&nbsp;Veronica Wendy Setiawan ,&nbsp;Lida Chatzi ,&nbsp;Ana C. Maretti-Mira","doi":"10.1016/j.envint.2025.109763","DOIUrl":"10.1016/j.envint.2025.109763","url":null,"abstract":"<div><h3>Background</h3><div>Although per- and polyfluoroalkyl substances (PFAS) have been linked to chronic liver diseases, the specific cellular and molecular mechanisms by which different PFAS contribute to human liver dysfunction remain unclear. This study aims to elucidate those mechanisms.</div></div><div><h3>Methods</h3><div>We exposed a multi-donor human liver spheroid model composed of multiple cell types to 20 µM of PFHxS, PFOA, PFOS, or PFNA for seven days, followed by single-cell RNA sequencing and lipid staining.</div></div><div><h3>Results</h3><div>PFAS impacted liver spheroids in a compound- and sex-specific manner. PFOA and PFHxS increased lipid accumulation, while PFOS and PFNA triggered multiple cancer-related pathways. PFOA upregulated de novo lipogenesis, particularly in female-derived hepatocytes, whereas PFHxS downregulated lipid transportation and efflux pathways across all hepatocytes. PFNA upregulated pathways involved in cell cycle progression, oxidative stress, DNA repair, and inflammation in hepatocytes from both sexes. Notably, 61.3% of the PFNA-exposed cells expressed a transcriptomic cancer signature. PFOS predominantly affected male-derived hepatocytes, showing a mild effect. All compounds impaired immune-related pathways in T/NK and Kupffer cells. Furthermore, PFAS exposure reduced cell–cell communication and elicited cellular interactions involved in angiogenesis, apoptosis, cell proliferation and adhesion, lipid metabolism, and inflammation.</div></div><div><h3>Conclusions</h3><div>Our findings suggest that PFAS disrupt liver metabolism and may promote pro-oncogenic signaling through compound- and sex-specific mechanisms. These insights enhance our understanding of PFAS hepatotoxicity and underscore the importance of considering sex as a biological variable in future toxicological and public health assessments.</div></div>","PeriodicalId":308,"journal":{"name":"Environment International","volume":"203 ","pages":"Article 109763"},"PeriodicalIF":9.7,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144928022","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cross-taxa sublethal impacts of plant protection products on honeybee in-hive and zebrafish swimming behaviours at environmentally relevant concentrations","authors":"Cassandra Uthoff ,&nbsp;Nadia K. Herold ,&nbsp;Abdulrahim T. Alkassab ,&nbsp;Beatrice Engelmann ,&nbsp;Ulrike Rolle-Kampczyk ,&nbsp;Jens Pistorius ,&nbsp;Nicole Schweiger ,&nbsp;Saskia Finckh ,&nbsp;Martin Krauss ,&nbsp;Andreas S. Thum ,&nbsp;Nico Jehmlich ,&nbsp;Tamara Tal ,&nbsp;Martin von Bergen","doi":"10.1016/j.envint.2025.109750","DOIUrl":"10.1016/j.envint.2025.109750","url":null,"abstract":"<div><div>Single and mixture exposure to plant protection products (PPPs) can affect non-target organisms at sublethal concentrations, yet the ecological relevance of behavioural effects remains underexplored. Behavioural disruptions can compromise survival and fitness, with exposure occurring across terrestrial and aquatic ecosystems. Here, we assess the behavioural impact of environmentally relevant PPP concentrations on two ecologically and toxicologically important model species: honeybees (<em>Apis mellifera</em>) and zebrafish (<em>Danio rerio</em>). These organisms represent distinct exposure pathways: pollinator-specific routes such as oral uptake of contaminated nectar and pollen or contact during overspray and foraging, and freshwater contamination via runoff. In honeybees, in-hive behaviours were monitored using a snapshot method from days three to ten after exposure, while zebrafish behavioural endpoints were quantified using a 26-endpoint visual and acoustic motor response (VAMR) assay. Sublethal PPP exposure (1.99–7.81 ng/µL in honeybee hives, 0.0253–27.5 ng/µL in zebrafish assay) caused significant, substance-specific behavioural alterations. In honeybees, flupyradifurone (SIVANTO® prime) significantly decreased foraging and nectar processing, while boscalid (Cantus®) and terbuthylazine (ClickPro®) minimised brood-tending behaviours. Insecticides and fungicides affected honeybees most, while zebrafish embryos were especially sensitive to the herbicide terbuthylazine. They exhibited concentration-dependent neurotoxic phenotypes, with behavioural profiles of the PPPs mixture (consistent with concentrations in German streams: 41.54 % boscalid, 0.013 % flupyradifurone, 58.45 % terbuthylazine) shifting along a terbuthylazine–boscalid gradient. These findings show that PPPs can elicit pronounced behavioural changes in non-target species, even at low environmental concentrations. These results support incorporating in-hive and early-life stage behavioural assays into pesticide risk assessments and warrant mechanistic studies on PPP-induced neurotoxicity.</div></div>","PeriodicalId":308,"journal":{"name":"Environment International","volume":"203 ","pages":"Article 109750"},"PeriodicalIF":9.7,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144906316","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The associations between prenatal rare earth elements exposure and preterm birth: integrate insights from birth cohort and in vitro study","authors":"Zhongqiang Cao ,&nbsp;Ziwen Kong ,&nbsp;Hongjian Gong ,&nbsp;Xiaoyuan Feng ,&nbsp;Ruizhen Li ,&nbsp;Shunqing Xu ,&nbsp;Han Xiao ,&nbsp;Aifen Zhou","doi":"10.1016/j.envint.2025.109757","DOIUrl":"10.1016/j.envint.2025.109757","url":null,"abstract":"<div><div>Rare earth elements (REEs) are emerging environmental contaminants, yet their effects on preterm birth (PTB) remain poorly understood. This study integrates epidemiological and mechanistic evidence to evaluate REEs-associated PTB risk and potential biological pathways. We analyzed 4,897 mother–child pairs from a large cohort in China and 13 REEs in maternal urine were measured. PTB risk was assessed via logistic regression and weighted quantile sum (WQS) models. HTR-8/SVneo trophoblasts were used to evaluate cell invasion (Transwell assays), matrix metalloproteinase-9(MMP-9)/ tissue inhibitor of matrix metalloproteinase-1 (TIMP-1) expression (western blot), and transcriptomic profiles (RNA-seq) after REEs treatment. Median concentrations (0.006–0.065 μg/g creatinine) and detection frequencies (90–100 %) of 12 REEs were higher in PTB cases (P &lt; 0.05). Each log₂-unit increase in individual and mixture of REEs exposure elevated PTB risk by 18–51 % after adjusting for covariates. Cerium (Ce), praseodymium (Pr) and gadolinium (Gd) were the primary contributors. Environmentally-relevant REEs concentrations (0.5–100 μg/L) treatment enhanced trophoblast invasion by 2.7–19.2 folds, accompanied by MMP-9 upregulation and TIMP-1 suppression in dose-dependently. Transcriptome analysis revealed 1,425 shared differentially expressed genes, prominently affecting ribosome biogenesis and oxidative phosphorylation pathways. These findings establish REEs as hazardous environmental contaminants impacting maternal-fetal health, providing crucial evidence for reevaluating exposure guidelines.</div></div>","PeriodicalId":308,"journal":{"name":"Environment International","volume":"203 ","pages":"Article 109757"},"PeriodicalIF":9.7,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144916191","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Metabolome informs about the chemical exposome and links to brain health","authors":"Matej Orešič ,&nbsp;Naama Karu ,&nbsp;Haoqi Nina Zhao ,&nbsp;Arthur Moseley ,&nbsp;Thomas Hankemeier ,&nbsp;David S. Wishart ,&nbsp;Pieter C. Dorrestein ,&nbsp;Oliver Fiehn ,&nbsp;Tuulia Hyötyläinen ,&nbsp;Rima Kaddurah Daouk ,&nbsp;The Alzheimer Gut Microbiome Project","doi":"10.1016/j.envint.2025.109741","DOIUrl":"10.1016/j.envint.2025.109741","url":null,"abstract":"<div><div>The metabolome is an intermediate phenotype, summarizing the profile of all small molecules (&lt;1.5 kDa) in biospecimens. The metabolome provides a readout for the net influence of the chemical exposome, diet, gut microbiome, and genome on human health. Metabolic changes observed in exposome studies may thus provide clues about adverse outcome pathways related to cancer, diabetes, heart disease, cognitive impairment and other neurological conditions such as Alzheimer’s disease (AD). Whilst the number of human cohort studies including both metabolomic and exposomic profiles is increasing, they are particularly limited in the domain of neurological conditions. Environmental exposures and chemical toxicants are known to have significant effects on the brain, gut microbiome, and gut-brain axis. Environmental chemicals of greatest interest include bisphenols, phthalates, persistent organic pollutants such as polychlorinated biphenyls (PCBs) and per- and poly-fluoroalkyl substances (PFAS), heavy metals, chemicals from household products and pesticides/herbicides; all of which may increase the risk of AD as they impact relevant biochemical mechanisms, especially with chronic exposure. In this review we describe how the chemical exposome can be assessed, including the approach our consortium is taking in the context of AD. Further, we review the current evidence about the impact of the chemical exposome on cognition as well as its influence on the risk and pathogenesis of AD. Finally, we highlight our approach to study the exposome in AD as part of large national and international collaborative efforts on the topic.</div></div>","PeriodicalId":308,"journal":{"name":"Environment International","volume":"203 ","pages":"Article 109741"},"PeriodicalIF":9.7,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144922286","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Air pollution and bone health outcomes: Periods of susceptibility from pregnancy to childhood","authors":"Lieke E.J.M. Scheepers ,&nbsp;Anne-Claire Binter ,&nbsp;Susana Santos ,&nbsp;Sami Petricola ,&nbsp;Fernando Rivadeneira ,&nbsp;Vincent W.V. Jaddoe ,&nbsp;Mònica Guxens ,&nbsp;Fay H. Johnston","doi":"10.1016/j.envint.2025.109739","DOIUrl":"10.1016/j.envint.2025.109739","url":null,"abstract":"<div><h3>Background</h3><div>Early life exposure to environmental factors can impact skeletal development. We aimed to identify periods of susceptibility to air pollution in early life in relation to bone health outcomes at age six.</div></div><div><h3>Methods</h3><div>Data were from the Generation R study, a population-based pregnancy cohort study, The Netherlands. We estimated daily concentrations of nitrogen dioxide (NO2) and particulate matter (PM10, PM2.5 and PM2.5 absorbance) at the home addresses during pregnancy and childhood, using land-use regression models. Bone mineral density and area-adjusted bone mineral content were measured by dual-energy x-ray absorptiometry at age six. We performed distributed lag modelling (DLM) adjusted for several socioeconomic characteristics to assess the associations between bone health and air pollution, using 28-day averaged exposure levels, and identify windows of susceptibility.</div></div><div><h3>Results</h3><div>Among 5966 children, we identified windows of susceptibility from ∼ 1 to ∼ 4 years of age for PM2.5 and PM2.5 absorbance with bone mineral density (e.g., −10.3; 95 % CI −15.8 to −4.7 per 5 µg/m³ increase in PM2.5) and for all air pollutants with bone mineral content (e.g., −14.6; 95 % CI −20.7 to −8.4 per 5 µg/m³ increase in PM2.5). Also, we identified an association between NO2 and PM2.5 absorbance during pregnancy and higher bone mineral content (e.g., 4.0; 95 % CI 1.4 to 6.6 per 10^-5 m⁻¹ increase in PM2.5 absorbance). In the sex-stratified analyses, associations across all exposures and outcome measures were in the same direction for both sexes, and similar to the main analyses, but statistically significance was observed only in boys.</div></div><div><h3>Conclusions</h3><div>Our findings suggest that exposure to air pollutants during childhood may already lead to poorer bone health outcomes.</div></div>","PeriodicalId":308,"journal":{"name":"Environment International","volume":"203 ","pages":"Article 109739"},"PeriodicalIF":9.7,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144922288","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exposure to per- and polyfluoroalkyl substances during fetal development and risk of testicular germ cell cancer in adulthood","authors":"Cecilie S. Uldbjerg ,&nbsp;Youn-Hee Lim ,&nbsp;Astrid L. Beck ,&nbsp;Jørgen H. Petersen ,&nbsp;Karina M. Sørensen ,&nbsp;David M. Kristensen ,&nbsp;Panu Rantakokko ,&nbsp;Brent A. Coull ,&nbsp;Christian Lindh ,&nbsp;Niels E. Skakkebæk ,&nbsp;Russ Hauser ,&nbsp;Elvira V. Bräuner ,&nbsp;Lærke Priskorn ,&nbsp;Anders Juul","doi":"10.1016/j.envint.2025.109762","DOIUrl":"10.1016/j.envint.2025.109762","url":null,"abstract":"<div><h3>Background</h3><div>Testicular germ cell cancer (TGCC) originates during fetal life. Fetal exposure to environmental chemicals may contribute to its development, but epidemiological data are lacking. We investigated per- and polyfluoroalkyl substances (PFAS), which can act as endocrine disruptors during fetal development, and TGCC risk in adulthood.</div></div><div><h3>Methods</h3><div>We conducted a nested case-control study of 549 mother-male offspring pairs (103 TGCC cases, 446 matched controls). The source population included over 100,000 pregnant women with biobanked serum samples collected during 1985–1994, a period before PFAS restrictions. Male offspring were followed for up to 38 years, and TGCC cases were identified from the Danish Cancer Registry based on histological confirmation. Eight PFAS were quantified in maternal serum using LC-MS/MS. Associations between individual PFAS and their mixtures with TGCC risk were assessed through Cox regression and quantile g-computation models.</div></div><div><h3>Results</h3><div>Associations between individual PFAS and TGCC risk were modest and not statistically significant. Hazard ratios (HRs) for perfluoroalkyl sulfonic acids (PFOS, PFHxS, PFHpS) suggested higher TGCC risks per quartile increase in concentrations, but lower risks for perfluoroalkyl carboxylic acids (PFOA, PFNA, PFDA, PFHpA, PFUnDA). Mixture analyses supported this pattern, with higher TGCC risk for the joint effect of sulfonic acids (HR 1.13, 95 % CI: 0.89; 1.44). Stratified analyses by histological subtype showed higher risk for seminomas than for nonseminomas across all PFAS.</div></div><div><h3>Conclusions</h3><div>We found limited evidence of an association between fetal PFAS exposure and TGCC risk. Indications of a potential adverse effect of perfluoroalkyl sulfonic acids, particularly for seminomas, merit further research.</div></div>","PeriodicalId":308,"journal":{"name":"Environment International","volume":"203 ","pages":"Article 109762"},"PeriodicalIF":9.7,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144910814","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"High temperature and mental health in 3.3 million adults living in Barcelona metropolitan area: a 12-year time series analysis of primary care data","authors":"Andrea Pistillo ,&nbsp;Agustina Giuliodori ,&nbsp;Anna Palomar-Cros ,&nbsp;Elisa Gallo ,&nbsp;Enric Aragonès ,&nbsp;Joan Ballester ,&nbsp;Marc Marí-Dell’Olmo ,&nbsp;Xavier Basagaña ,&nbsp;Talita Duarte-Salles","doi":"10.1016/j.envint.2025.109748","DOIUrl":"10.1016/j.envint.2025.109748","url":null,"abstract":"<div><div>Extreme temperatures and mental health are both public health concerns. Yet, evidence on the impact of extreme temperature on mental health is still scarce. Here, we studied the short-term association between daily temperatures and the risk of a primary care diagnoses, medication prescription and sick leaves for anxiety and depression.</div><div>We conducted a time series analysis of adults living in the Barcelona metropolitan area from 2011 to 2022 using a primary care individual-level database in Catalonia, Spain. We defined outcomes related to anxiety and depression (diagnoses, medication prescriptions and sick leaves). We estimated daily mean temperature extracted from Meteocat for the area. We fitted a quasi-Poisson regression with distributed lag non-linear models for assessing the short-term association of temperature on the events of interest.</div><div>Among 3,303,841 adults, 11.7 % and 4.2 % had a diagnosis of anxiety and depression, 32.3 % and 20.1 % had at least a prescription of anxiolytics or antidepressants, and 4.9 % and 0.9 % at least a sick leave for anxiety or depression, respectively. High daily mean temperatures (26 °C, 95th percentile), with respect to the temperature of minimum risk (1 °C), increased the risk of anxiety (43 %), anxiolytic prescriptions (20 %), sick leaves for anxiety (65 %), depression (26 %) and sick leaves for depression (43 %). The exposure and most of the outcomes showed an increasing trend.</div><div>High temperatures may be associated with increased risk of anxiety and depression outcomes in the Barcelona Metropolitan Area.</div></div>","PeriodicalId":308,"journal":{"name":"Environment International","volume":"203 ","pages":"Article 109748"},"PeriodicalIF":9.7,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144901099","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Assessing cold exposure risk during cold waves in Beijing using high spatiotemporal resolution population data and temperature variations","authors":"Yaqin Bu ,&nbsp;Zhaobin Sun ,&nbsp;Yan Tao ,&nbsp;Wenxi Ruan ,&nbsp;Xiaoling Zhang ,&nbsp;Yinglin Liang ,&nbsp;Yuxin Zhao","doi":"10.1016/j.envint.2025.109773","DOIUrl":"10.1016/j.envint.2025.109773","url":null,"abstract":"<div><div>In the context of global warming, the frequency and intensity of extreme weather events are intensifying. Although cold waves have significant impacts on human health, related research remains insufficient. This study integrates high-resolution population dynamics and temperature data to assess cold exposure risks during cold waves in Beijing, addressing a critical research gap in urban public health. We have developed an advanced cold exposure risk assessment framework aimed at uncovering the potential health threats posed by winter cold waves to urban residents. Our findings reveal that population movement between urban and suburban areas significantly affects cold exposure risks, with nighttime dynamics exacerbating exposure levels. Specifically, nighttime population dynamics substantially exacerbate cold exposure levels, while daytime population dynamics, due to the urban heat island effect, to some extent reduce cold exposure risks. Additionally, compared to traditional average temperature metrics, dynamically population-weighted temperatures more accurately reflect actual cold exposure risks. The findings of this study provide valuable insights for urban public health management, emphasizing the importance of considering population mobility in public health strategies for responding to extreme weather events.</div></div>","PeriodicalId":308,"journal":{"name":"Environment International","volume":"203 ","pages":"Article 109773"},"PeriodicalIF":9.7,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144928028","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Early-life nutritional additives, household environment, and air pollution in relation to childhood food allergies: A multi-city mother–child study in China","authors":"Chan Lu ,&nbsp;Ying Jiang ,&nbsp;Wen Deng ,&nbsp;Mengju Lan ,&nbsp;Lin Wang ,&nbsp;Yeqing Tong ,&nbsp;Zipeng Qiao ,&nbsp;Wanxue Xu ,&nbsp;Ting Li ,&nbsp;Weiwei Liu ,&nbsp;Faming Wang","doi":"10.1016/j.envint.2025.109774","DOIUrl":"10.1016/j.envint.2025.109774","url":null,"abstract":"<div><h3>Background</h3><div>Nutritional supplements and environments have been linked with food allergy (FA), but little research has explored their interactions on children’s FA.</div></div><div><h3>Objectives</h3><div>To explore the associations between early-life nutritional supplements, household environmental factors (HEFs), and outdoor air pollutant (OAP) exposures, and their interactions on children’s FAs.</div></div><div><h3>Methods</h3><div>We collected 20,730 surveyed questionnaires from five Chinese cities, covering data on individual characteristics, health outcomes, and HEFs. Multilevel logistic regression models were conducted to establish the impacts of early-life nutritional supplements, HEFs, and OAP exposures on children’s FAs.</div></div><div><h3>Results</h3><div>Children’s FA was negatively associated with maternal intake of iron, vitamins A-E, cod-liver oil, docosahexaenoic acid (DHA), protein powder, and prebiotic/probiotics/synbiotics during pregnancy, as well as childhood intake of iron, selenium, vitamin A, B, C, E, and cod-liver oil. Childhood intake of vitamin D and prebiotic/probiotics/synbiotics increased FA risk. Using ceramic tile/stone/cement floor, silicone rubber baby bottle, and fresh air filter reduced FA risk. Conversely, using glass baby bottle, plastic toy, air conditioning in summer, and mosquitos increased FA risk. FA was consistently positively associated with NO₂ exposure within the first trimester, while not consistently related with other pollutants in different models. Maternal and childhood intake of nutritional supplements mitigated adverse impacts of HEFs and OAP exposure on FA, while amplifying protective effects, indicating a nutrition-pollution interaction.</div></div><div><h3>Conclusions</h3><div>Early-life nutritional supplements, HEFs, and OAP exposures separately and jointly influence children’s FA. However, the possibility of false positives due to multiple testing cannot be excluded, which should be interpreted with caution pending replication.</div></div>","PeriodicalId":308,"journal":{"name":"Environment International","volume":"203 ","pages":"Article 109774"},"PeriodicalIF":9.7,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144928133","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}