Environment International最新文献

{"title":"Meet-in-the-middle meets multi-omics identifying molecular signatures of environmental drivers of childhood overweight","authors":"Congrong Wang ,&nbsp;Brigitte Reimann ,&nbsp;Tim S Nawrot ,&nbsp;Dries S Martens ,&nbsp;John Wright ,&nbsp;Rosemary McEachan ,&nbsp;Johanna Lepeule ,&nbsp;Wenlun Yuan ,&nbsp;Leda Chatzi ,&nbsp;Marina Vafeiadi ,&nbsp;Regina Grazuleviciene ,&nbsp;Sandra Andrusaityte ,&nbsp;Oliver Robinson ,&nbsp;Jordi Sunyer ,&nbsp;Hector Keun ,&nbsp;Chung-Ho E. Lau ,&nbsp;Alexandros P. Siskos ,&nbsp;Muireann Coen ,&nbsp;Eva Borràs ,&nbsp;Eduard Sabidó ,&nbsp;Rossella Alfano","doi":"10.1016/j.envint.2025.109630","DOIUrl":"10.1016/j.envint.2025.109630","url":null,"abstract":"<div><h3>Background</h3><div>Obesity is a multi-cause chronic disease recognized across the lifespan, with childhood obesity prevalence rising over the past decades. Although exposome-wide association studies have identified early-life environmental drivers of child obesity, and explored the multi-omics signatures of the exposome of children, it is understudied whether the combined effects of multiple exposures are potentially mediated by multi-omics.</div></div><div><h3>Methods</h3><div>Within the Human Early Life Exposome (HELIX) project, 1041 mother–child pairs were surveyed for a wide range of environmental exposures including over 354 prenatal and childhood exposures. Multi-omics molecular features were measured during childhood, encompassing the blood methylome and transcriptome, plasma proteins and urinary and serum metabolites. Exposome and multi-omics features were integrated into latent factors by Multi-omics Factor Analysis, based on which structural equation modelling was used to assess whether multi-omics mediated associations between exposome and child body mass index (BMI).</div></div><div><h3>Results</h3><div>Key findings included: (i) prenatal nutrition, exercise, and passive smoking influencing BMI via DNA methylation of <em>HOXA5</em> and <em>Tenascin XB</em>; (ii) childhood exposure to PCBs and phenols linked with BMI through inflammation and coagulation pathways; and (iii) childhood PCB and dietary exposures associated with BMI via immune pathways.</div></div><div><h3>Conclusions</h3><div>This novel untargeted workflow elucidated biological mechanisms linking environmental exposures to child obesity, potentially supporting targeted public health interventions.</div></div>","PeriodicalId":308,"journal":{"name":"Environment International","volume":"202 ","pages":"Article 109630"},"PeriodicalIF":10.3,"publicationDate":"2025-06-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144370936","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"High-resolution modelling of particulate matter chemical composition over Europe: brake wear pollution","authors":"Abhishek Upadhyay ,&nbsp;Jianhui Jiang ,&nbsp;Yun Cheng ,&nbsp;Petros Vasilakos ,&nbsp;Ying Chen ,&nbsp;Daniel Trejo Banos ,&nbsp;Benjamin Flückiger ,&nbsp;Manousos I. Manousakas ,&nbsp;André S.H. Prévôt ,&nbsp;Robin L. Modini ,&nbsp;Ana Sánchez de la Campa ,&nbsp;Andrea Schemmel ,&nbsp;Andrés Alastuey ,&nbsp;Benjamin Bergmans ,&nbsp;Célia A. Alves ,&nbsp;Christoph Hueglin ,&nbsp;Cristina Colombi ,&nbsp;Cristina Reche ,&nbsp;Daniel Sánchez-Rodas ,&nbsp;Dario Massabò ,&nbsp;Imad El-Haddad","doi":"10.1016/j.envint.2025.109615","DOIUrl":"10.1016/j.envint.2025.109615","url":null,"abstract":"<div><div>In today’s rapidly evolving society, the sources of atmospheric particulate matter (PM) emissions are shifting significantly. Stringent regulations on vehicle tailpipe emissions, in combination with a lack of control of non-exhaust vehicular emissions, have led to an increase in the relative contribution of non-exhaust PM in Europe. This study analyzes the spatial distribution, temporal trends, and impacts of brake wear PM pollution across Europe by modeling copper (Cu) concentrations at a high spatial resolution of ∼250 m which is a key tracer of brake-wear emissions. We integrated coarse-resolution brake-wear Cu from CAMx chemical transport model and high-resolution land use data into a random forest (RF) model to predict Cu concentrations at ∼250 m over whole of continental Europe. The RF model was trained using an unprecedented dataset of over 50,000 daily Cu measurements from 152 sites. It corrected CAMx underestimation and downscaled Cu to a higher spatial resolution. In validation, the model showed robust spatial and temporal prediction with good Pearson’s correlation coefficients of 0.6 and 0.7, respectively. We generated 10 years (2010–2019) of daily Cu concentrations over Europe, revealing spatial patterns aligned with urbanization and road networks, with peaks in cities and lower values in rural areas. Temporal trends reveal that Cu concentrations generally peak on weekdays and in winter. Despite a decline in PM across Europe over decades, Cu concentrations showed no decrease in many cities from 2010 to 2019. Cu levels are strongly correlated with population density with more than 12 million Europeans exposed to levels exceeding 40 ng/m³, equivalent to around 1 μg/m³ of total PM₁₀ from brake wear. Our findings highlight the need for expanded metal measurement for non-exhaust tracers for a better understanding of the health relevance of PM composition including Cu, and more effective regulations of non-exhaust PM emissions as included in EURO 7 vehicles.</div></div>","PeriodicalId":308,"journal":{"name":"Environment International","volume":"202 ","pages":"Article 109615"},"PeriodicalIF":10.3,"publicationDate":"2025-06-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144337909","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Strong bioaccumulation of a wide variety of PFAS in a contaminated terrestrial and aquatic ecosystem","authors":"Ioanna S. Gkika ,&nbsp;J. Arie Vonk ,&nbsp;Thomas L. ter Laak ,&nbsp;Cornelis A.M. van Gestel ,&nbsp;Jildou Dijkstra ,&nbsp;Thimo Groffen ,&nbsp;Lieven Bervoets ,&nbsp;Michiel H.S. Kraak","doi":"10.1016/j.envint.2025.109629","DOIUrl":"10.1016/j.envint.2025.109629","url":null,"abstract":"<div><div>The widespread use of Per- and Poly Fluorinated Substances (PFAS) in a multitude of industrial and consumer applications, together with their persistence and mobility, has led to global contamination of the abiotic and biotic environment. Nevertheless, important knowledge gaps remain concerning PFAS occurrence and bioaccumulation, with studies tending to focus either on aquatic or on terrestrial ecosystems, with a bias towards the aquatic environment. The aim of the present study was therefore to investigate the distribution and bioaccumulation of various PFAS in a contaminated terrestrial and aquatic ecosystem. Subsequently, it was examined if the calculated bioaccumulation factors are related to PFAS molecular descriptors. Abiotic and biotic samples were collected from the aquatic and terrestrial compartments of a PFAS contaminated ecosystem and screened for 44 compounds. PFAS were present in all environmental compartments with varying profiles and concentrations. Generally, higher concentrations were found in aquatic than in terrestrial biota as well as in animals compared to plants. Biota-to-soil and biota-to-sediment accumulation factors (BSAFs) demonstrated a strong bioaccumulation of PFAS, reaching 96,708 kg sediment/kg biota. Similarly, a high bioconcentration potential from water was observed, with bioconcentration factors (BCFs) reaching 55,597 L water/kg biota. The membrane-water partition coefficient (K_mw) explained PFAS bioaccumulation to some extent, but the still limited understanding of factors driving PFAS bioaccumulation calls for further mechanistic research. Nonetheless, it is concluded that many of the 44 analyzed PFAS strongly bioaccumulate in terrestrial and aquatic primary producers and animals, making these compounds of great environmental concern for the coming decades.</div></div>","PeriodicalId":308,"journal":{"name":"Environment International","volume":"202 ","pages":"Article 109629"},"PeriodicalIF":10.3,"publicationDate":"2025-06-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144337868","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Spatially resolved analysis of speciated VOC emissions and their contributions to secondary pollutant formation: a comparative assessment of anthropogenic and biogenic sources in China","authors":"Yu Wang ,&nbsp;Haomiao Cheng ,&nbsp;Tianfang Kang ,&nbsp;Wei Wei ,&nbsp;Xiaoli Liu","doi":"10.1016/j.envint.2025.109627","DOIUrl":"10.1016/j.envint.2025.109627","url":null,"abstract":"<div><div>Volatile organic compounds (VOCs) significantly impact ozone (O₃) and particulate matter (PM_2.5) formation, requiring spatially resolved emission and reactivity assessments for air pollution control. Here, we developed a 27 km-grid speciated VOC emission inventory involving both anthropogenic and biogenic sources over mainland China in 2021, by combining the traditional emission factor method with refined spatial allocation method. Total VOC emissions reached 66.7 Tg, with biogenic sources contributing 65.0 % and anthropogenic sources 35.0 %, and their emission intensities varied from 0 to 684.9 t/km², peaking in South (24.7 t/km²) and East China (23.8 t/km²), while lowest in the Northwest (1.7 t/km²). Then, the speciated VOC emissions were further combined with their OH reaction rates and secondary organic aerosol (SOA) yield, to respectively achieve their OH reactivity (OHR_E) and SOA formation potential (SOAP_E). The national average OHR_E, calculated across all grid cells in China, for VOCs was 3028.9 s⁻¹, far exceeding the counterparts for inorganic components, while the national mean SOAP_E was 0.3 t/km², contributing 38.3 % to PM_2.5 emission. Both OHR_E and SOAP_E displayed significant spatial heterogeneity, with OHR_E decreasing from south to north, peaking in South China (11016.0 s⁻¹) and reaching its lowest in the Northwest (602.6 s⁻¹). In contrast, SOAP_E showed less regional variation but was highest in urban agglomerations, including the Pearl River Delta (1.6 t/km²), Yangtze River Delta (1.3 t/km²), and Beijing-Tianjin-Hebei (0.6 t/km²). This study is the first to quantify the spatial variability of OHR_E and SOAP_E using a gridded emission inventory, uncovering differences between anthropogenic and biogenic contributions and supporting targeted regional pollution control strategies.</div></div>","PeriodicalId":308,"journal":{"name":"Environment International","volume":"202 ","pages":"Article 109627"},"PeriodicalIF":10.3,"publicationDate":"2025-06-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144337856","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The impact of particle size and volatile organics on the light absorption of wildfire-like brown carbon emissions from wood combustion","authors":"Constantinos Moularas ,&nbsp;Irini Tsiodra ,&nbsp;Nikolaos Mihalopoulos ,&nbsp;Philip Demokritou ,&nbsp;Georgios A. Kelesidis","doi":"10.1016/j.envint.2025.109626","DOIUrl":"10.1016/j.envint.2025.109626","url":null,"abstract":"<div><div>Here, the light absorption of brown carbon (BrC) emitted by wood combustion and denuded from volatile organic carbon (VOC) at 300 °C is elucidated using a recently developed thermal decomposition platform coupled with a suite of real-time aerosol instrumentation and time-integrated sampling systems. The BrC particle size distribution, morphology and optical properties are closely controlled by increasing the combusted wood mass from 50 to 600 mg to emulate those measured for “real world” wildfire particulate matter (PM) emissions. Size-fractionation of such wildfire-like BrC reveals that the PM_0.1–2.5 fraction contains high molecular weight, carcinogenic polycyclic aromatic hydrocarbons (PAHs) and absorbs up to five times more light compared to the PM_0.1 fraction. Thus, increasing the combusted wood mass from 50 to 600 mg increases the PM_0.1–2.5 concentration by a factor of about eight and enhances the overall BrC mass absorption cross-section, <em>MAC</em>, up to a factor of two at a wavelength of 405 nm. Condensation of VOC on BrC reduces its <em>MAC</em> up to 40 %. Still, the particle size seems to largely determine the BrC light absorption, as large VOC-rich particles absorb more light compared to small VOC-lean ones. The size-resolved BrC <em>MAC</em> measured here can be interfaced with climate models to estimate the climate impact of wildfire PM emissions.</div></div>","PeriodicalId":308,"journal":{"name":"Environment International","volume":"202 ","pages":"Article 109626"},"PeriodicalIF":10.3,"publicationDate":"2025-06-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144334856","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Identification of VOC emission hotspots in industrial parks by high-spatiotemporal-resolution sensor networks","authors":"Xiaocan Bai ,&nbsp;Yuhan Huang ,&nbsp;Yanhui Wang ,&nbsp;Ziyi Wang ,&nbsp;Xue Li ,&nbsp;Ruixue Du ,&nbsp;Manyun Long ,&nbsp;Huawei Zhang ,&nbsp;Yan Tan ,&nbsp;Ting Liu ,&nbsp;Chun Chen ,&nbsp;Xianhui Fan ,&nbsp;Yanru Xu ,&nbsp;Jinping Cheng ,&nbsp;Shengao Jing ,&nbsp;Zizhen Ma ,&nbsp;Zehui Li ,&nbsp;Jingkun Jiang","doi":"10.1016/j.envint.2025.109628","DOIUrl":"10.1016/j.envint.2025.109628","url":null,"abstract":"<div><div>Industrial emissions are a significant contributor to volatile organic compound (VOC) pollution. However, timely and accurate tracking of high-emitting plants within industrial parks remains a challenge. Here, we deployed three high-density VOC sensor networks across a package printing industrial park (103 sites/km²), a fine chemical industrial park (8.57 sites/km²), and an urban area in central China. These networks enabled the identification of VOC pollution characteristics and sources in regions. The hourly average VOC concentrations in the package printing industrial park (320 ± 262 ppb) and the fine chemical industrial park (155 ± 62 ppb) were 1.62 to 2.75 times and 1.27 to 1.70 times higher compared to the urban area. Pollution levels in these two industrial parks were more severe than other reported industrial parks, primarily due to the higher VOC emission factors or higher VOC emission fluxes associated with these industries. Importantly, by integrating VOC concentration contour maps with meteorological data, major polluting plants in the package printing industrial park and the fine chemical industrial park were identified. These were further validated through downwind tracing of VOC species using gas chromatography-mass spectrometry. The results highlight that a VOC sensor network is an effective tool for real-time monitoring of VOC variations and the precise identification of high-pollution plants across various industrial parks, which can provide valuable insights for the refined control and management of VOC pollution emissions.</div></div>","PeriodicalId":308,"journal":{"name":"Environment International","volume":"202 ","pages":"Article 109628"},"PeriodicalIF":10.3,"publicationDate":"2025-06-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144334855","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Corrigendum to “A three-dimensional mouse liver organoid platform for assessing EDCs metabolites simulating liver metabolism” [Environ. Int. 195 (2025) 109184]","authors":"Ji Hyun Moon, Hyun-Soo Roh, Young Jae Park, Hyun Ho Song, Jieun Choi, Da Woon Jung, Soo Jin Park, Ho Jin Park, So-Hyeon Park, Da-Eun Kim, Gahee Kim, Joong-Hyuck Auh, Dong Ha Bhang, Hong Jin Lee, Do Yup Lee","doi":"10.1016/j.envint.2025.109623","DOIUrl":"https://doi.org/10.1016/j.envint.2025.109623","url":null,"abstract":"The authors regret, the correct affiliation of the author ‘<strong>Ho Jin Park</strong>’ is updated as above.","PeriodicalId":308,"journal":{"name":"Environment International","volume":"8 1","pages":""},"PeriodicalIF":11.8,"publicationDate":"2025-06-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144334858","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Assessing the risk of antimicrobial resistance and potential environmental harm through national-scale surveillance of antimicrobials in hospital and community wastewater","authors":"Neil Andrew Byrnes ,&nbsp;Reshma Silvester ,&nbsp;Gareth Cross ,&nbsp;Andrew J. Weightman ,&nbsp;Davey L. Jones ,&nbsp;Barbara Kasprzyk-Hordern","doi":"10.1016/j.envint.2025.109606","DOIUrl":"10.1016/j.envint.2025.109606","url":null,"abstract":"<div><div>Antimicrobial resistance (AMR) is a major public health concern. Antimicrobial residues enter wastewater where their continued presence can lead to an increased risk of AMR while also causing environmental harm when untreated wastewater is discharged into the environment. This research presents the antimicrobial residue surveillance results of a national-scale wastewater sampling campaign across Wales. Wastewater from 15 sites—effluent from 7 hospitals and influent from 8 community wastewater treatment plants—was collected for 5 consecutive days monthly from May–July 2023. This campaign captured more than 30 % of the Welsh population and over 30 % of the population receiving care as hospital inpatients. Using a quantitative approach, over 175 unique wastewater samples were analyzed by ultra-performance liquid chromatography tandem mass spectrometry (UPLC–MS/MS) for more than 40 antimicrobials including: β-lactams, macrolides, quinolones, sulfonamides, a veterinary antibiotic, an antifungal, antivirals, and numerous metabolites. The most prevalent antimicrobials were clarithromycin, its metabolite N-desmethyl clarithromycin, fluconazole, and trimethoprim as they were detected in all samples. Sulfamethoxazole concentrations ranged from 724–28031 ng/L and trimethoprim ranged from 785–44539 ng/L in hospital effluent—concentrations significantly higher than those reported in published literature. In hospital wastewater, many antimicrobials were present at concentrations which were orders of magnitude higher than their respective predicted no-effect concentrations (PNECs) for antibiotic resistance selection (e.g., metronidazole, trimethoprim). These concentrations create a selective pressure which can drive AMR emergence. Furthermore, some antimicrobials remained at high-risk concentrations even after dilution in community wastewater (e.g., ciprofloxacin, clarithromycin). Environmental risk assessments also identified clarithromycin and ciprofloxacin as agents of concern while vancomycin posed the highest environmental risk (concentrations ca. 1000–38000-fold &gt; PNEC in hospital effluent) should this wastewater enter the environment untreated (e.g., combined sewer overflows). Instances of direct disposal of antimicrobials were clearly identified in hospital wastewater. These results demonstrate the importance of regular monitoring of AMR and potential environmental risk posed by antimicrobials in wastewater, while demonstrating the need for comprehensive national action (e.g., treatment of hospital wastewater on-site, tertiary/quaternary treatment of community wastewater, tailored stewardship programs, focussed control efforts on high-risk antimicrobials) to minimize risks to public health and the environment.</div></div>","PeriodicalId":308,"journal":{"name":"Environment International","volume":"202 ","pages":"Article 109606"},"PeriodicalIF":10.3,"publicationDate":"2025-06-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144334860","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Regional variations in the impacts of high temperature on hospital admissions in Brazil","authors":"Huiqi Chen ,&nbsp;Ivan Augusto Cecilio e Silva ,&nbsp;Shakoor Hajat ,&nbsp;Letícia Xander Russo ,&nbsp;Kai Wan ,&nbsp;Cherie Part ,&nbsp;Zhifu Mi ,&nbsp;Josephine Borghi ,&nbsp;Dorothea Nitsch ,&nbsp;Everton Nunes da Silva ,&nbsp;Anna M. Foss","doi":"10.1016/j.envint.2025.109620","DOIUrl":"10.1016/j.envint.2025.109620","url":null,"abstract":"<div><h3>Background</h3><div>High temperatures driven by climate change significantly threaten global health. Their impact on health systems, particularly within low- and middle-income countries, remains underexplored.</div></div><div><h3>Methods</h3><div>Daily non-elective hospital admissions were collected from the Brazil Hospital Information System for 5,459 (98%) Brazilian municipalities, 2008–2019. Gridded daily maximum temperatures were obtained from the European Centre for Medium-Range Weather Forecasts Reanalysis V5 for the historical period (2008–2023) and projected up to 2060 under three SSP emission scenarios. Population projections were derived from WorldPop. We used a case time-series design and distributed lag non-linear models to examine the relationship between temperature and hospitalisation risk for each state, estimating the number of heat-attributable hospitalisations from 2008 to 2060. Related economic costs were estimated using a cost-of-illness approach including direct and indirect costs.</div></div><div><h3>Findings</h3><div>Without adaptation, high-temperature-related annual hospitalisations were projected to reach 51 (95 % CI: 19–103), 54 (21–106), and 59 (25–112) per 100,000 population in the 2050s under SSP1-2.6, SSP2-4.5, and SSP5-8.5 scenarios, respectively, representing 54 %, 62 %, and 78 % increases from the 2010s baseline of 33 (9–67) per 100,000. Annual economic costs were projected to reach $228–$264 million in the 2050s, with higher absolute costs in the South and faster relative increases in the North.</div></div><div><h3>Interpretation</h3><div>The substantial impact of heat on hospitalisations, and its associated costs to the health sector and wider economy, worsen under future climate and demographic change. Regional adaptation and targeted healthcare investments are crucial to manage rising health burdens.</div></div><div><h3>Funding</h3><div>UK Research and Innovation; China Scholarship Council.</div></div>","PeriodicalId":308,"journal":{"name":"Environment International","volume":"202 ","pages":"Article 109620"},"PeriodicalIF":10.3,"publicationDate":"2025-06-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144334862","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Towards circular food production systems: Identification of chemical, microbial, and physical food safety hazards in municipal sludge and excess aerobic biomass of the food industry","authors":"Katja C.W. van Dongen ,&nbsp;Gijs W. Spaans ,&nbsp;Edwin M. Foekema ,&nbsp;Johan W. van Groenestijn ,&nbsp;A. Maarten J. Kootstra ,&nbsp;Michael S.M. Brouwer ,&nbsp;Dirkjan Schokker ,&nbsp;Paul B. Stege ,&nbsp;Bas van Dijk ,&nbsp;René A.M. Dirks ,&nbsp;Denise van de Kamer ,&nbsp;Ruben Kause ,&nbsp;Erik de Lange ,&nbsp;Stefan P.J. van Leeuwen ,&nbsp;Katharina Verhaelen ,&nbsp;Menno van der Voort ,&nbsp;Elise F. Hoek-van den Hil","doi":"10.1016/j.envint.2025.109624","DOIUrl":"10.1016/j.envint.2025.109624","url":null,"abstract":"<div><div>There is a need in Europe to re-use residual streams to move towards a more circular food production system in the future. Sludge from both municipal wastewater (sewage) treatment plants and from wastewater treatment plants of the food industry (i.e., aerobic biomass) are present in large volumes, contain nutrients, and are currently mostly incinerated in the Netherlands. This makes them an interesting source for re-use in food production systems. However, prior to re-use of these streams in a food production system, the presence of hazardous substances (chemicals, microbiological, and physical) needs to be evaluated to safeguard food safety of such systems. This study aims to evaluate this in sewage sludge collected from multiple locations and in excess aerobic biomass from food industry plants, sampled at 2 – 4 time points. Hazards were analyzed in all samples and included pathogenic bacteria, microbial composition, antimicrobial resistance (genes), viruses, heavy metals, pharmaceutical and pesticide residues, short-chain per- and polyfluoroalkyl substances, dioxins, and physical hazards. Generally, aerobic biomass from wastewater treatment plants of the food industry contained less of the above-mentioned hazards as compared to sludge from municipal wastewater treatment plants. When available, hazard concentrations were compared with maximum limits for fertilizer applications. For heavy metals, these limits were especially exceeded by found cadmium concentrations. Overall, the results of the present study will contribute to the design of safe circular food production systems and showcase the need for a fit-for-purpose and safe-by-design approach in the application of residual streams in food production systems.</div></div>","PeriodicalId":308,"journal":{"name":"Environment International","volume":"202 ","pages":"Article 109624"},"PeriodicalIF":10.3,"publicationDate":"2025-06-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144329427","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}