Environment International最新文献

{"title":"Modifying effects of vitamin D on associations between per- and polyfluoroalkyl substances exposure and risk of gestational diabetes mellitus: A prospective cohort study in Beijing, China","authors":"Feng Han ,&nbsp;Ziwei Pei ,&nbsp;Bing Lyu ,&nbsp;Xin Zhang ,&nbsp;Jian Zhang ,&nbsp;Jiaying Liu","doi":"10.1016/j.envint.2025.109641","DOIUrl":"10.1016/j.envint.2025.109641","url":null,"abstract":"<div><div>Epidemiology studies suggested that exposure to Per- and Polyfluoroalkyl Substances (PFAS) might elevate the incidence of Gestational Diabetes Mellitus (GDM), but no study considered the modifying roles of vitamin D, an important nutrient related to GDM development. Thus, this study evaluated the modifying effects of maternal vitamin D on correlations of PFAS exposure with GDM by conducting a cohort study in Beijing, China. We recruited 111 pregnant women who had either one or more high risk factors for GDM in Beijing, China, in 2022. Blood samples collected from pregnant women in 11–13 gestational weeks were analyzed to detect 19 PFAS and 25-hydroxy vitamin D. GDM was confirmed via the Oral Glucose Tolerance Test (OGTT). All subjects were classed as possessing sufficient, insufficient, or deficient vitamin D concentrations. Vitamin D deficiency status was observed to be a significant modifier for associations between GDM risk and PFAS exposure, as well as continuous glucose concentrations in an OGTT (interaction <em>p</em>-value &lt; 0.05). For women with vitamin D deficiency, exposure to five long-chain perfluoroalkyl carboxylates significantly elevated the GDM risk (<em>p</em> &lt; 0.05), and the overall estimated risk ratio for GDM associated with 1 ng/mL increases in PFAS ranged from 3.750 to 8.097. The results suggested that adequate supplementation of vitamin D during early pregnancy could prevent the elevated risk of GDM caused by PFAS exposure.</div></div>","PeriodicalId":308,"journal":{"name":"Environment International","volume":"202 ","pages":"Article 109641"},"PeriodicalIF":10.3,"publicationDate":"2025-06-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144488484","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Adherence to the 3+30+300 urban green space rule and mental health, physical activity, and overweight: A population-based study in the Netherlands","authors":"Marco Helbich ,&nbsp;Matthew H.E.M. Browning ,&nbsp;Dirk Voets ,&nbsp;Payam Dadvand","doi":"10.1016/j.envint.2025.109643","DOIUrl":"10.1016/j.envint.2025.109643","url":null,"abstract":"<div><h3>Background</h3><div>The 3+30+300 guideline aims to establish a standard for healthier cities to enhance population health through the provision of trees and green space; however, little empirical evidence to support its effectiveness is available.</div></div><div><h3>Objectives</h3><div>We aimed to 1) evaluate the adherence to the 3+30+300 urban green space rule in the Netherlands; 2) examine the associations between the 3+30+300 rule (and its components) and adults’ health and behavioral outcomes; and 3) assess possible effect modifications by age, sex, income, and urbanicity.</div></div><div><h3>Methods</h3><div>We used population-based health survey data for 2022 from the Netherlands. Adults’ general health, psychological complaints, anxiety and depression symptoms, psychological resilience, physical activity, and overweight were assessed alongside the 3+30+300 rule at the residential addresses. Covariate-adjusted mixed effects logistic regressions estimated the associations of health and behavioral outcomes with the 3+30+300 components—individually and jointly. Subgroup analyses based on age, sex, income, and urbanicity were also conducted.</div></div><div><h3>Results</h3><div>Of the 180,949 respondents, 16.4 % met the 3+30+300 rule. Respondents meeting the 3+30+300 rule were significantly less likely to be overweight and were significantly more likely to be physically active than those not meeting the rule. Neither meeting the 3+30+300 rule nor its components showed any association with other health or behavioral outcomes. We found no notable effect modification by age, sex, income, and urbanicity.</div></div><div><h3>Conclusions</h3><div>Our findings suggest that meeting the 3+30+300 green space rule may promote certain health benefits, particularly by supporting better weight management and higher physical activity levels, though its role in mental health remains inconclusive.</div></div>","PeriodicalId":308,"journal":{"name":"Environment International","volume":"202 ","pages":"Article 109643"},"PeriodicalIF":10.3,"publicationDate":"2025-06-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144488754","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Development of a highly sensitive reporter gene cell line for detecting estrogenic activity (the ER Isjaki assay)","authors":"Aline Colonnello Montero,&nbsp;Geeta Mandava,&nbsp;Agneta Oskarsson,&nbsp;Johan Lundqvist","doi":"10.1016/j.envint.2025.109635","DOIUrl":"10.1016/j.envint.2025.109635","url":null,"abstract":"<div><div>Monitoring of estrogens in water sources faces significant challenges, as proposed changes in the European Union regulation for environmental protection of water bodies, compromise the ability of conventional analytical methods to detect low concentrations of estrogens. The proposed changes involve the decrease of the environmental quality standards for 17β-estradiol, estrone and 17α-ethinyl estradiol in surface waters and the obligation to monitor estrogenic substances in water bodies, using effect-based methods. In this study, the optimal experimental conditions for developing a novel and highly sensitive reporter gene assay were established. For this purpose, optimization of transfection plasmid concentration, exposure time and basement membrane matrix effect as well as assessment of assay reproducibility and relative effect potency of natural estrogens and estrogenic substances were conducted. With the optimal experimental conditions set as 5 ng per well in 96-well uncoated plates for plasmid transfection and 24 h exposure to treatments, the assay yielded an average sensitivity, measured as effect level 20 % for 17β-estradiol, estrone and 17α-ethinyl estradiol of 0.29, 1.36 and 0.02 pM, respectively. The assay showed a reproducibility variation of approximately 20 % and was able to differentiate the relative effect potency between 17α-ethinyl estradiol and 17β-estradiol with the capacity of detecting 17α-ethinyl estradiol with a high relative effect potency. Moreover, this assay is approximately 10–100 times more sensitive compared to the current state-of-the-art <em>in vitro</em> assays used to measure estrogenicity, indicating that the assay can be used to detect 17β-estradiol, estrone and 17α-ethinyl estradiol at the low levels needed to meet regulatory standards.</div></div>","PeriodicalId":308,"journal":{"name":"Environment International","volume":"202 ","pages":"Article 109635"},"PeriodicalIF":10.3,"publicationDate":"2025-06-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144479601","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of intermediate and long-term exposure to ambient air pollution and temperature on hospital admissions with second cardiovascular events among medicare beneficiaries","authors":"Mahdieh Danesh Yazdi ,&nbsp;Yaguang Wei ,&nbsp;Qian Di ,&nbsp;Weeberb J. Requia ,&nbsp;Adjani A. Peralta ,&nbsp;Francesca Dominici ,&nbsp;Joel D. Schwartz","doi":"10.1016/j.envint.2025.109617","DOIUrl":"10.1016/j.envint.2025.109617","url":null,"abstract":"<div><h3>Background</h3><div>Air pollution has been linked to cardiovascular diseases (CVDs). In this study, we assess whether exposure to air pollutants and ambient temperature is associated with repeated admissions with adverse cardiovascular outcomes.</div></div><div><h3>Methods</h3><div>We used data from Medicare beneficiaries between 2000 and 2016 to look at the effects of intermediate and long-term exposure to ambient PM_2.5, NO₂, O₃, and temperature on second admissions with myocardial infarction (MI) and ischemic stroke. We derived exposure levels from high-resolution spatiotemporal models. We adjusted for demographic, socioeconomic, and access-to-care characteristics. Cox proportional hazards models were used to assess these relationships. We further looked at the effects of exposure at lower air pollution concentrations defined as PM_2.5 &lt; 9 µg/m³, NO₂ &lt; 25 ppb, and O₃ &lt; 50 ppb.</div></div><div><h3>Results</h3><div>PM_2.5 and NO₂ increased the hazard of second admissions with both MI and stroke. For PM_2.5, the effects were more pronounced for longer exposure time windows. Each µg/m³ increase in one-year PM_2.5 levels before the first admission increased the hazard of a second admission with MI by 1.1% (95% CI: 1.0%-1.2%) and stroke by 0.9% (95% CI: 0.8%-1.1%). O₃ exhibited a slight protective effect for both outcomes. Higher temperatures were associated with a higher hazard of second admissions with stroke. These results persisted at lower concentrations.</div></div><div><h3>Conclusion</h3><div>Our study demonstrates that exposures to PM_2.5 and NO₂ are associated with increased rates of second admissions with MIs and strokes. Higher temperatures were also further associated with an increase in the rate of second admissions with stroke.</div></div>","PeriodicalId":308,"journal":{"name":"Environment International","volume":"202 ","pages":"Article 109617"},"PeriodicalIF":10.3,"publicationDate":"2025-06-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144479604","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Potential systemic availability classification of chemicals for safety assessment","authors":"René Geci ,&nbsp;Alicia Paini ,&nbsp;Andrew P Worth ,&nbsp;Lars Kuepfer ,&nbsp;Stephan Schaller","doi":"10.1016/j.envint.2025.109636","DOIUrl":"10.1016/j.envint.2025.109636","url":null,"abstract":"<div><div>The assessment of chemical safety is essential for protecting human health, yet current approaches have severe limitations. They are unable to address the rapidly growing number of substances requiring evaluation and further rely on animal testing, which the public expects to be phased out for ethical reasons. To address this, the European Partnership for Alternative Approaches to Animal Testing (EPAA) proposed the use of a novel framework for the classification of systemic toxicity based on new approach methodologies. One dimension of this framework is the grouping of substances into different classes of Potential Systemic Availability (PSA) concern (low, medium, high). But so far it remained conceptually and practically unclear how this classification can be achieved. Here, we outline the theoretical considerations for a health-protective definition of PSA concern classes and present a method for the quantitative evaluation of this property. Using high-throughput physiologically based kinetic modelling, we are able to classify the PSA concerns of 139 out of 150 EPAA NAM Designathon compounds. Further, we manually annotate these compounds to evaluate the plausibility of predicted classifications against expert judgement. Our results outline under which circumstances it is appropriate to prioritise or deprioritise chemicals due to their toxicokinetic properties. However, we find that most compounds cannot be assessed on their PSA alone and need to be considered medium PSA concern so that classification into any overall systemic toxicity concern class remains possible. Future integration of bioactivity data will be necessary to fully judge the utility of our method and of the entire framework.</div></div>","PeriodicalId":308,"journal":{"name":"Environment International","volume":"202 ","pages":"Article 109636"},"PeriodicalIF":10.3,"publicationDate":"2025-06-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144479539","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exploring the relationship between the androgen receptor and structural configuration of benzophenones: a combination of computational analysis and laboratory models","authors":"Da-Hyun Jeong ,&nbsp;Rajesh Kumar Pathak ,&nbsp;Da-Woon Jung ,&nbsp;Jun-Mo Kim ,&nbsp;Hee-Seok Lee","doi":"10.1016/j.envint.2025.109632","DOIUrl":"10.1016/j.envint.2025.109632","url":null,"abstract":"<div><div>This study explored the interactions between benzophenones (BPs) and androgen receptors (AR) using computational and experimental approaches. BPs are potential endocrine disruptors that are commonly found in cosmetics, such as sunscreen. Molecular docking and molecular mechanics with generalized Born and surface area continuum solvation calculations revealed that dihydroxylation form of BP-1, BP-2 had higher binding affinities to AR compared with BP-1, BP-3. Key interactions with residues, such as Gln711 and Asn705, were identified. Density functional theory analysis revealed that BP-2 has a balanced energy gap, which contributes to its stability and reactivity. Cell-based assays validated these computational results, showing that BP-2 had stronger AR antagonistic effect than BP-1 and BP-3. Furthermore, BP-2 enhances the AR-mediated luciferase signal at specific concentration through inducing dimerization of cytosolic AR, whereas BP-1 and BP-3 had no AR agonistic effects. These changes in AR-mediated transcriptional activation activity were observed in flutamide and hydroxyflutamide as well. As expected, changes in AR-mediated endocrine disrupting potential due to configurational modification of BP-1 to BP-2 by dihydroxylation resulted in whole AR protein expression. These findings suggest that BP-2 is a strong AR modulator and a potential endocrine disruptor, offering insights into how similar compounds may interact with AR.</div></div>","PeriodicalId":308,"journal":{"name":"Environment International","volume":"202 ","pages":"Article 109632"},"PeriodicalIF":10.3,"publicationDate":"2025-06-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144371068","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exposure to “Forever Chemical” perfluorooctanoic acid induces depression-like behaviors in mice by activating the HPA axis","authors":"Ya Wang ,&nbsp;Yuning Chen ,&nbsp;Houlin Chen ,&nbsp;James N Samsom ,&nbsp;Minfei Shu ,&nbsp;Xuehui Gao ,&nbsp;Qiyu Li ,&nbsp;Kangmin Chen ,&nbsp;Le Wang ,&nbsp;Fang Liu","doi":"10.1016/j.envint.2025.109631","DOIUrl":"10.1016/j.envint.2025.109631","url":null,"abstract":"<div><div>Perfluorooctanoic acid (PFOA), an environmental endocrine disruptor, has been found to increase the expression of corticotropin-releasing factor (CRF) in the paraventricular nucleus (PVN). In this study, adult male mice were given PFOA by oral gavage (p.o.) to evaluate whether it disrupts systems related to mood disorders. PFOA exposure (5 mg/kg) for 10 consecutive days caused depression-like behaviors in male mice. We measured increased corticosterone in serum and in the hippocampus of PFOA-exposed mice, which were linked to enhanced CRF expression measured in the PVN. Elevated corticosterone was associated with reductions in glucocorticoid receptor (GR) protein expression within the hippocampus. CRFR1 antagonist injected into the PVN and intracerebroventricular (i.c.v.) GR antagonist both reduced depression-like behaviors, respectively. In addition, NMDA-dependent Schaeffer collateral-CA3 synaptic transmission in PFOA-exposed mice was disrupted. Synaptic deficits could be corrected by either CRFR1 or GR antagonists. In summary, we found exposure of male mice to PFOA enhances CRF expression, which then activates the HPA axis to disrupt GR expression in the hippocampus, leading to depression-like behaviors. This data is relevant for understanding the potential harmful health effects of PFOA.</div></div>","PeriodicalId":308,"journal":{"name":"Environment International","volume":"202 ","pages":"Article 109631"},"PeriodicalIF":10.3,"publicationDate":"2025-06-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144371058","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Meet-in-the-middle meets multi-omics identifying molecular signatures of environmental drivers of childhood overweight","authors":"Congrong Wang ,&nbsp;Brigitte Reimann ,&nbsp;Tim S Nawrot ,&nbsp;Dries S Martens ,&nbsp;John Wright ,&nbsp;Rosemary McEachan ,&nbsp;Johanna Lepeule ,&nbsp;Wenlun Yuan ,&nbsp;Leda Chatzi ,&nbsp;Marina Vafeiadi ,&nbsp;Regina Grazuleviciene ,&nbsp;Sandra Andrusaityte ,&nbsp;Oliver Robinson ,&nbsp;Jordi Sunyer ,&nbsp;Hector Keun ,&nbsp;Chung-Ho E. Lau ,&nbsp;Alexandros P. Siskos ,&nbsp;Muireann Coen ,&nbsp;Eva Borràs ,&nbsp;Eduard Sabidó ,&nbsp;Rossella Alfano","doi":"10.1016/j.envint.2025.109630","DOIUrl":"10.1016/j.envint.2025.109630","url":null,"abstract":"<div><h3>Background</h3><div>Obesity is a multi-cause chronic disease recognized across the lifespan, with childhood obesity prevalence rising over the past decades. Although exposome-wide association studies have identified early-life environmental drivers of child obesity, and explored the multi-omics signatures of the exposome of children, it is understudied whether the combined effects of multiple exposures are potentially mediated by multi-omics.</div></div><div><h3>Methods</h3><div>Within the Human Early Life Exposome (HELIX) project, 1041 mother–child pairs were surveyed for a wide range of environmental exposures including over 354 prenatal and childhood exposures. Multi-omics molecular features were measured during childhood, encompassing the blood methylome and transcriptome, plasma proteins and urinary and serum metabolites. Exposome and multi-omics features were integrated into latent factors by Multi-omics Factor Analysis, based on which structural equation modelling was used to assess whether multi-omics mediated associations between exposome and child body mass index (BMI).</div></div><div><h3>Results</h3><div>Key findings included: (i) prenatal nutrition, exercise, and passive smoking influencing BMI via DNA methylation of <em>HOXA5</em> and <em>Tenascin XB</em>; (ii) childhood exposure to PCBs and phenols linked with BMI through inflammation and coagulation pathways; and (iii) childhood PCB and dietary exposures associated with BMI via immune pathways.</div></div><div><h3>Conclusions</h3><div>This novel untargeted workflow elucidated biological mechanisms linking environmental exposures to child obesity, potentially supporting targeted public health interventions.</div></div>","PeriodicalId":308,"journal":{"name":"Environment International","volume":"202 ","pages":"Article 109630"},"PeriodicalIF":10.3,"publicationDate":"2025-06-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144370936","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"High-resolution modelling of particulate matter chemical composition over Europe: brake wear pollution","authors":"Abhishek Upadhyay ,&nbsp;Jianhui Jiang ,&nbsp;Yun Cheng ,&nbsp;Petros Vasilakos ,&nbsp;Ying Chen ,&nbsp;Daniel Trejo Banos ,&nbsp;Benjamin Flückiger ,&nbsp;Manousos I. Manousakas ,&nbsp;André S.H. Prévôt ,&nbsp;Robin L. Modini ,&nbsp;Ana Sánchez de la Campa ,&nbsp;Andrea Schemmel ,&nbsp;Andrés Alastuey ,&nbsp;Benjamin Bergmans ,&nbsp;Célia A. Alves ,&nbsp;Christoph Hueglin ,&nbsp;Cristina Colombi ,&nbsp;Cristina Reche ,&nbsp;Daniel Sánchez-Rodas ,&nbsp;Dario Massabò ,&nbsp;Imad El-Haddad","doi":"10.1016/j.envint.2025.109615","DOIUrl":"10.1016/j.envint.2025.109615","url":null,"abstract":"<div><div>In today’s rapidly evolving society, the sources of atmospheric particulate matter (PM) emissions are shifting significantly. Stringent regulations on vehicle tailpipe emissions, in combination with a lack of control of non-exhaust vehicular emissions, have led to an increase in the relative contribution of non-exhaust PM in Europe. This study analyzes the spatial distribution, temporal trends, and impacts of brake wear PM pollution across Europe by modeling copper (Cu) concentrations at a high spatial resolution of ∼250 m which is a key tracer of brake-wear emissions. We integrated coarse-resolution brake-wear Cu from CAMx chemical transport model and high-resolution land use data into a random forest (RF) model to predict Cu concentrations at ∼250 m over whole of continental Europe. The RF model was trained using an unprecedented dataset of over 50,000 daily Cu measurements from 152 sites. It corrected CAMx underestimation and downscaled Cu to a higher spatial resolution. In validation, the model showed robust spatial and temporal prediction with good Pearson’s correlation coefficients of 0.6 and 0.7, respectively. We generated 10 years (2010–2019) of daily Cu concentrations over Europe, revealing spatial patterns aligned with urbanization and road networks, with peaks in cities and lower values in rural areas. Temporal trends reveal that Cu concentrations generally peak on weekdays and in winter. Despite a decline in PM across Europe over decades, Cu concentrations showed no decrease in many cities from 2010 to 2019. Cu levels are strongly correlated with population density with more than 12 million Europeans exposed to levels exceeding 40 ng/m³, equivalent to around 1 μg/m³ of total PM₁₀ from brake wear. Our findings highlight the need for expanded metal measurement for non-exhaust tracers for a better understanding of the health relevance of PM composition including Cu, and more effective regulations of non-exhaust PM emissions as included in EURO 7 vehicles.</div></div>","PeriodicalId":308,"journal":{"name":"Environment International","volume":"202 ","pages":"Article 109615"},"PeriodicalIF":10.3,"publicationDate":"2025-06-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144337909","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Strong bioaccumulation of a wide variety of PFAS in a contaminated terrestrial and aquatic ecosystem","authors":"Ioanna S. Gkika ,&nbsp;J. Arie Vonk ,&nbsp;Thomas L. ter Laak ,&nbsp;Cornelis A.M. van Gestel ,&nbsp;Jildou Dijkstra ,&nbsp;Thimo Groffen ,&nbsp;Lieven Bervoets ,&nbsp;Michiel H.S. Kraak","doi":"10.1016/j.envint.2025.109629","DOIUrl":"10.1016/j.envint.2025.109629","url":null,"abstract":"<div><div>The widespread use of Per- and Poly Fluorinated Substances (PFAS) in a multitude of industrial and consumer applications, together with their persistence and mobility, has led to global contamination of the abiotic and biotic environment. Nevertheless, important knowledge gaps remain concerning PFAS occurrence and bioaccumulation, with studies tending to focus either on aquatic or on terrestrial ecosystems, with a bias towards the aquatic environment. The aim of the present study was therefore to investigate the distribution and bioaccumulation of various PFAS in a contaminated terrestrial and aquatic ecosystem. Subsequently, it was examined if the calculated bioaccumulation factors are related to PFAS molecular descriptors. Abiotic and biotic samples were collected from the aquatic and terrestrial compartments of a PFAS contaminated ecosystem and screened for 44 compounds. PFAS were present in all environmental compartments with varying profiles and concentrations. Generally, higher concentrations were found in aquatic than in terrestrial biota as well as in animals compared to plants. Biota-to-soil and biota-to-sediment accumulation factors (BSAFs) demonstrated a strong bioaccumulation of PFAS, reaching 96,708 kg sediment/kg biota. Similarly, a high bioconcentration potential from water was observed, with bioconcentration factors (BCFs) reaching 55,597 L water/kg biota. The membrane-water partition coefficient (K_mw) explained PFAS bioaccumulation to some extent, but the still limited understanding of factors driving PFAS bioaccumulation calls for further mechanistic research. Nonetheless, it is concluded that many of the 44 analyzed PFAS strongly bioaccumulate in terrestrial and aquatic primary producers and animals, making these compounds of great environmental concern for the coming decades.</div></div>","PeriodicalId":308,"journal":{"name":"Environment International","volume":"202 ","pages":"Article 109629"},"PeriodicalIF":10.3,"publicationDate":"2025-06-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144337868","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}