Environment International最新文献

{"title":"Combining fugacity and physiologically based toxicokinetic concepts in a mechanistic model describing the fate of lipophilic contaminants in lactating cows","authors":"Sylvain Lerch ,&nbsp;Olivier Martin ,&nbsp;Agnés Fournier ,&nbsp;Isabelle Ortigues-Marty ,&nbsp;Jérôme Henri","doi":"10.1016/j.envint.2025.109509","DOIUrl":"10.1016/j.envint.2025.109509","url":null,"abstract":"<div><div>Quantifying the fate of lipophilic contaminants in lactating cows is the cornerstone for ensuring the chemical safety of dairy products and beef meat. Exploring the effects of cow feeding and physiology on the toxicokinetics of several lipophilic contaminants requires an integrative approach. This study developed and evaluated a mechanistic model (RuMoPOP) of the absorption, distribution, metabolism, and excretion (ADME) of lipophilic contaminant in lactating cows. The model’s rationale relies on the coupling of ADME with physiological sub-models. The ADME sub-model merges the concepts and advantages of former fugacity and physiologically based toxicokinetic models. The physiological sub-model is based on a model that finely describes the dynamics of lipids in the digestive contents, body, and milk, depending on the milk production level (from a low-yielding suckler cow to a high-yielding dairy cow). The model was fitted to toxicokinetic data from two dairy cow experiments for polychlorinated biphenyls, dibenzo-<em>p</em>-dioxins, and dibenzofurans. Model performances for predicting milk accumulation and depuration kinetics were judged satisfactory, with an average root mean square error relative to the observed mean of 27%. The model makes it possible to predict the variability in accumulation and depuration kinetics, depending on contaminant lipophilicity, hepatic clearance rate, and diet lipid content and digestibility, over the whole lifespan of low- and high-yielding cows. The RuMoPOP model is a valuable tool for exploring the complex interplay between lipophilic contaminant properties and cow physiology and ultimately contributes to the chemical safety of diverse dairy and beef production systems towards legacy and emerging lipophilic contaminants.</div></div>","PeriodicalId":308,"journal":{"name":"Environment International","volume":"199 ","pages":"Article 109509"},"PeriodicalIF":10.3,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143889850","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Triggering tumorigenic signaling: Succinate dehydrogenase inhibitor (SDHi) fungicides induce oncometabolite accumulation and metabolic shift in human colon cells","authors":"Carolina Duarte Hospital ,&nbsp;Arnaud Tête ,&nbsp;Kloé Debizet ,&nbsp;Clémence Rives ,&nbsp;Jules Imler ,&nbsp;Sofiane Safi-Stibler ,&nbsp;Lara Gales ,&nbsp;Floriant Bellvert ,&nbsp;Julien Dairou ,&nbsp;Auriane Hagimont ,&nbsp;Agnès Burel ,&nbsp;Dominique Lagadic-Gossmann ,&nbsp;Robert Barouki ,&nbsp;Jerry W. Shay ,&nbsp;Jean Bastin ,&nbsp;Sophie Mouillet-Richard ,&nbsp;Anthony Lemarié ,&nbsp;Fatima Djouadi ,&nbsp;Sandrine Ellero-Simatos ,&nbsp;Xavier Coumoul ,&nbsp;Sylvie Bortoli","doi":"10.1016/j.envint.2025.109503","DOIUrl":"10.1016/j.envint.2025.109503","url":null,"abstract":"<div><div>Succinate dehydrogenase inhibitors (SDHi) are fungicides used worldwide to control the proliferation of fungi in crops. They act by blocking the activity of succinate dehydrogenase (SDH), a universal enzyme involved in mitochondrial functions and metabolism. While SDH-encoding genes are tumour suppressors, which loss-of-function mutations predispose to different types of rare tumors in humans, the consequences of chemical inactivation of SDH by SDHi remain largely unknown, particularly regarding their carcinogenic potential. Here, we investigated the metabolic and cellular impact of SDHi on human non-cancer and transformed colon cells. We show that SDHi inhibit SDH activity and increase the level of succinate, known to act as an oncometabolite in SDH-deficient cancers. SDHi exposure also induces a Warburg-like metabolic reprogramming typical of cancer cells, associated with transcriptomic and morphological changes promoting cell migration and invasion. These effects are enhanced in transformed colon cells carrying mutations in colorectal cancer (CRC) driver genes. These findings provide the first evidence that SDHi-mediated chemical inactivation of SDH mimics some metabolic and phenotypic features previously described in human tumors with SDH genetic deficiencies. Given that loss of SDH expression in CRC patients correlates with a poor prognosis, these patients could represent a population sensitive to SDHi exposure. Therefore, it would be wise to include them in biomonitoring programs. Finally, our work highlights the need to improve regulatory assessment procedures to take better account of SDHi mode of action, by developing relevant tests to cover the multiple key events linked to SDH inactivation and assess the resulting mitochondrial toxicity.</div></div>","PeriodicalId":308,"journal":{"name":"Environment International","volume":"199 ","pages":"Article 109503"},"PeriodicalIF":10.3,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143897896","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Population aging exacerbates heat stroke-related ambulance transportations in Japan","authors":"Qiang Guo ,&nbsp;Lina Madaniyazi ,&nbsp;Shuhei Nomura ,&nbsp;Kai Chen ,&nbsp;Masahiro Hashizume","doi":"10.1016/j.envint.2025.109506","DOIUrl":"10.1016/j.envint.2025.109506","url":null,"abstract":"<div><div>Rapid aging significantly increases Japan’s population vulnerability to severe heat stress, yet the precise impact on heat stroke-related morbidity remains unclear. This study integrates multiple datasets and develops predictive models for daily heat stroke-related emergency ambulance dispatches (HT-EADs) among younger and older populations in Japan for 2010–2019. By adjusting the proportion of older adults and incorporating pseudo climate warming, we assessed how aging and warming could amplify total HT-EADs. Compared to the simulation using demographic conditions of 1995, recent aging trends have led to a 15% increase in total HT-EADs in Japan during 2010–2019, an effect equivalent to a 0.3℃ warming. This increase could rise to 30% under a super-aging demographic scenario by 2045, surpassing the impact of a 0.5℃ warming. Our findings emphasize that aging has comparable negative impacts on heat stroke morbidity as climate change, highlighting the urgent need of enhanced protections for older residents during hot summers.</div></div>","PeriodicalId":308,"journal":{"name":"Environment International","volume":"199 ","pages":"Article 109506"},"PeriodicalIF":10.3,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143889847","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Organophosphate pesticides modulate gut microbiota and influence bile acid metabolism in an in vitro fermentation model","authors":"Weijia Zheng ,&nbsp;Wouter Bakker ,&nbsp;Maojun Jin ,&nbsp;Jing Wang ,&nbsp;Ivonne M.C.M. Rietjens","doi":"10.1016/j.envint.2025.109469","DOIUrl":"10.1016/j.envint.2025.109469","url":null,"abstract":"<div><div>Widely used organophosphate (OP) pesticides are shown to be of acute neurotoxicity; however, OP residues were frequently reported to be present in our living surroundings, posing a risk to human health. In this study, the effects of OP pesticides on gut microbiota mediated bile acid metabolism were investigated using a simple batch fermentation in vitro model, in which mouse fecal samples were incubated with six OPs and a mixture of bile acids. Samples were taken during the 24 h incubation and bile acid profiles were quantified by LC-MS/MS. OP treatment induced microbiota dependent alterations of primary and secondary bile acid levels, including especially substantially increased production of ω-muricholate and decreased levels of β-muricholate. As a result, phorate led to the most significant effects on the bile acid profile and was selected for further determination of accompanying effects on the bacterial profile by 16S rRNA sequencing. Results showed that richness of the <em>Muribaculaceae</em> spp. significantly decreased after the exposure to phorate. In summary, OP treatment could lead to perturbation of gut microbiota resulting in correlated changes in related bile acid metabolism.</div></div>","PeriodicalId":308,"journal":{"name":"Environment International","volume":"199 ","pages":"Article 109469"},"PeriodicalIF":10.3,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143853857","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Occurrence and profiles of glyphosate and aminomethylphosphonic acid in paired urine and feces of humans, cats, and dogs","authors":"Zhong-Min Li ,&nbsp;HuiHo Jeong ,&nbsp;Kurunthachalam Kannan","doi":"10.1016/j.envint.2025.109497","DOIUrl":"10.1016/j.envint.2025.109497","url":null,"abstract":"<div><div>We determined glyphosate and its degradation product, aminomethylphosphonic acid (AMPA), in paired urine and feces of humans (N = 14), cats (N = 10) and dogs (N = 21). The geometric mean (GM) concentrations of ∑Gly (sum of glyphosate and AMPA) in urine of humans, cats, and dogs were 0.89, 33.2, and 8.38 ng/mL, respectively, whereas those in corresponding feces were 304, 1290, and 424 ng/g dry weight (dw), respectively. The concentrations of glyphosate and AMPA were positively correlated in both urine and feces (R: 0.64–0.79, <em>p</em> &lt; 0.001), indicating co-exposure to these chemicals. Furthermore, the target analyte concentrations measured in paired urine and feces were significantly correlated (R: 0.72–0.75, <em>p</em> &lt; 0.001). The fecal excretion rates of ∑Gly (GM: 130–3350 ng/kg body weight (BW)/day) in humans and pets were 4–7 times higher than the corresponding urinary excretion rates (GM: 20.9–930 ng/kg BW/day), emphasizing that glyphosate and AMPA are predominantly excreted in feces. The cumulative daily intakes (CDI) of glyphosate and AMPA were estimated based on urinary and fecal excretion rates. The GM CDI of ∑Gly were 170, 4840, and 2410 ng/kg BW/day for humans, cats, and dogs, respectively, which were at least two orders of magnitude below the acceptable daily intake (ADI) of glyphosate (0.5 mg/kg BW/day). This study provides an important insight into exposure to and excretion of glyphosate in humans and companion animals.</div></div>","PeriodicalId":308,"journal":{"name":"Environment International","volume":"199 ","pages":"Article 109497"},"PeriodicalIF":10.3,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143872262","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Stroke risk associated with cold spells occurring during the warm season","authors":"Cheng He ,&nbsp;Susanne Breitner ,&nbsp;Siqi Zhang ,&nbsp;Markus Naumann ,&nbsp;Claudia Traidl-Hoffmann ,&nbsp;Gertrud Hammel ,&nbsp;Annette Peters ,&nbsp;Michael Ertl ,&nbsp;Alexandra Schneider","doi":"10.1016/j.envint.2025.109514","DOIUrl":"10.1016/j.envint.2025.109514","url":null,"abstract":"<div><h3>Background</h3><div>Recent climate changes have resulted in a rising frequency of extreme cold events that take place during the warm season. Few studies have investigated the impact of these warm-season cold spells on cardiovascular health. Here, we aimed to investigate the potential relationship between exposure to relatively low temperature exposure during the warm season and stroke risk.</div></div><div><h3>Methods</h3><div>We conducted a time-stratified case-crossover study using a validated, complete, and detailed registration of all stroke cases in the city of Augsburg, Germany, from 2006 to 2020 to assess the association between the occurrence of stroke and exposure to cold spell events during the warm season (May–October). Six cold spell definitions were created using different relative temperature thresholds (1st, 2.5th, and 5th percentiles) and durations (more than 1–2 consecutive days). Conditional logistic regression with distributed lag models was then applied to assess the accumulated effects of these warm-season cold spells on stroke risk over a lag period of 0–6 days, with adjustments for daily mean temperature.</div></div><div><h3>Results</h3><div>Results confirmed that warm-season cold spells were significantly linked to an elevated risk of stroke with effects that could persist three days after exposure. The cumulative odds ratio (OR) estimates for the cold spells using the 2.5th percentile as air temperature threshold reached 1.29 (95% confidence interval (CI): 1.09–1.53) and 1.23 (95%CI: 1.05–1.44) for durations more than one and two days, respectively. Warm-season cold spells also had significant associations with both transient ischemic attacks and ischemic strokes. The stratified analysis showed that the elderly population (aged ≥ 65 years), females, and stroke cases characterized by minor symptoms demonstrated a significantly increased stroke risk of the effects of warm season cold spells.</div></div><div><h3>Conclusions</h3><div>This study presents strong evidence for an overlooked association between warm-season cold spells and an increased risk of stroke occurrence. These findings further highlight the multifaceted ways in which climate change can affect human health.</div></div>","PeriodicalId":308,"journal":{"name":"Environment International","volume":"199 ","pages":"Article 109514"},"PeriodicalIF":10.3,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143894003","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of microplastics and tetracycline induced intestinal damage, intestinal microbiota dysbiosis, and antibiotic resistome: metagenomic analysis in young mice","authors":"Yanan Xia ,&nbsp;Yuzhi Lan ,&nbsp;Yunping Xu ,&nbsp;Faqun Liu ,&nbsp;Xiangxiang Chen ,&nbsp;Jinghua Luo ,&nbsp;Hengyi Xu ,&nbsp;Yang Liu","doi":"10.1016/j.envint.2025.109512","DOIUrl":"10.1016/j.envint.2025.109512","url":null,"abstract":"<div><div>Microplastics (MPs) and antibiotic tetracycline (TC) are widespread in the environment and constitute emerging combined contaminants. Young individuals are particularly vulnerable to agents that disrupt intestinal health and development. However, the combined effects of MPs and TC remain poorly understood. In this study, we developed a young mouse model exposed to polystyrene MPs, either alone or in combination with TC for 8 weeks to simulate real-life dietary exposure during early life. Our findings revealed that concurrent exposure to MPs and TC caused the most severe intestinal barrier dysfunction driven by inflammatory activation and oxidative imbalance. Moreover, exposure to MPs and TC reduced the abundance of potential probiotics while promoting the growth of opportunistic pathogens. Metagenomic analysis further indicated that co-exposure to MPs and TC enhanced the abundance of bacteria carrying either antibiotic resistance genes (ARGs) or virulence factor genes (VFGs), contributing to the widespread dissemination of potentially harmful genes. Finally, a strong positive correlation was observed between microbiota dysbiosis, ARGs, and VFGs. In general, this study highlighted the hazards of MPs and antibiotics to intestinal health in young mice, which provided a new perspective into the dynamics of pathogens, ARGs, and VFGs in early-life intestinal environments.</div></div>","PeriodicalId":308,"journal":{"name":"Environment International","volume":"199 ","pages":"Article 109512"},"PeriodicalIF":10.3,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143904344","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Untapped potential of wastewater for animal and potentially zoonotic virus surveillance: Pilot study to detect non-human animal viruses in urban settings","authors":"Mustafa Karatas ,&nbsp;Mandy Bloemen ,&nbsp;Jill Swinnen ,&nbsp;Inge Roukaerts ,&nbsp;Steven Van Gucht ,&nbsp;Marc Van Ranst ,&nbsp;Elke Wollants ,&nbsp;Jelle Matthijnssens","doi":"10.1016/j.envint.2025.109500","DOIUrl":"10.1016/j.envint.2025.109500","url":null,"abstract":"<div><h3>Introduction</h3><div>Wastewater surveillance has become an essential tool for monitoring viral outbreaks and surveillance of human viruses. While PCR-based methods are most frequently used, more advanced techniques, such as shotgun metagenomics in combination with viral capture methods, have been developed. These capture methods significantly improve the ability to detect nearly all (known) viruses at once in complex samples, including wastewater. In this study, we focus on tracking animal specific and zoonotic viruses in city wastewater using metagenomics combined with hybrid-capture approach.</div></div><div><h3>Methods</h3><div>We collected 6 wastewater samples from Leuven and Brussels, situated in the center of Belgium. Automated wastewater samplers collected 50 mL samples every 10 min resulting in a 24 h composite influent wastewater. All samples were processed using the TWIST comprehensive research panel capture, designed to target over 3,000 human and animal viruses species and 15,000 strains. Sequencing was performed on the AVITI sequencing platform, targeting an average of ten million reads per sample. The sequencing data were analyzed using the EsViritu tool.</div></div><div><h3>Results</h3><div>Over 2294 viral genomes or segments were recovered from wastewater samples. Of these, 168 were associated with non-human vertebrate animals, including cats, dogs, pigeons, and rats, spanning 51 virus species. We identified near-complete genomes of clinically relevant animal viruses, such as pigeon circovirus, chicken anemia virus, feline bocaparvovirus 2, canine minute virus, rat coronavirus, canine parvovirus, and porcine circovirus. Additionally, we noted the presence of viruses with known cross-species transmission potential, including porcine torovirus, rosavirus, hepatitis E virus, rat hepatitis virus, and cardiovirus.</div></div><div><h3>Conclusion</h3><div>The results demonstrate the ability to track a wide range of animal viruses in urban wastewater, potentially forming an early warning system for zoonotic diseases, ultimately being a useful tool for One Health based public health approaches.</div></div>","PeriodicalId":308,"journal":{"name":"Environment International","volume":"199 ","pages":"Article 109500"},"PeriodicalIF":10.3,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143878012","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ontogenetic, diurnal, and environmental impacts on VOC emission from sugarcane","authors":"Bin Hu ,&nbsp;Ann-Mareike Jarosch ,&nbsp;Rüdiger Grote ,&nbsp;Mbezele Junior Yannick Ngaba ,&nbsp;Jörg-Peter Schnitzler ,&nbsp;Jürgen Kreuzwieser ,&nbsp;Heinz Rennenberg","doi":"10.1016/j.envint.2025.109502","DOIUrl":"10.1016/j.envint.2025.109502","url":null,"abstract":"<div><div>Sugarcane (<em>Saccharum</em> spp. hybrid) is a key crop for bioenergy production due to its high productivity in tropical and subtropical climates. Despite this economic importance, there is currently no information available on the emission of volatile organic compounds (VOCs) during the growth phase of this crop. This is despite the fact that the sustainability of sugarcane cultivation has been questioned due to the associated land-use changes and possible atmospheric pollution by VOCs. The present study investigated the VOC emissions from sugarcane and their dependence on ontogenetic, diurnal, seasonal and environmental factors. By GC–MS and PTR-MS analysis, the emission of 40 different VOCs from sugarcane leaves was recorded based on their molecular weight that were divided into seven chemical groups (<em>i.e.,</em> alkanes, alkenes, aromatics, aldehydes, alcohols, ketones and terpenoids). In addition, complementary PTR-MS analysis showed strong emission of methanol, acetaldehyde and ethanol and minor release of monoterpenes, fatty acid derivatives (<em>i.e.,</em> LOX products) and a compound with <em>m</em>/<em>z</em> 69 (which was not validated as isoprene). Compared to other bioenergy crops, <em>e.g.,</em> maize, <em>Salix, Miscanthus</em> and poplar/aspen, terpenoid emissions play a quantitatively smaller role, indicating that sugarcane is a low impact species in terms of air chemistry. The VOC emissions from sugarcane leaves vary with plant developmental stages, during the day and between the seasons and are dependent on light intensity and temperature. Thus, our results could provide a valuable basis for future modelling efforts to upscale VOC emissions from sugarcane cultivation in different climatic zones.</div></div>","PeriodicalId":308,"journal":{"name":"Environment International","volume":"199 ","pages":"Article 109502"},"PeriodicalIF":10.3,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143880901","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Corrigendum to “Associations of dietary intake and longitudinal measures of per- and polyfluoroalkyl substances (PFAS) in predominantly Hispanic young Adults: a multicohort study” [Environ. Int 185 (2024) 108454]","authors":"Hailey E. Hampson ,&nbsp;Elizabeth Costello ,&nbsp;Douglas I. Walker ,&nbsp;Hongxu Wang ,&nbsp;Brittney O. Baumert ,&nbsp;Damaskini Valvi ,&nbsp;Sarah Rock ,&nbsp;Dean P. Jones ,&nbsp;Michael I. Goran ,&nbsp;Frank D. Gilliland ,&nbsp;David V. Conti ,&nbsp;Tanya L. Alderete ,&nbsp;Zhanghua Chen ,&nbsp;Leda Chatzi ,&nbsp;Jesse A. Goodrich","doi":"10.1016/j.envint.2025.109520","DOIUrl":"10.1016/j.envint.2025.109520","url":null,"abstract":"","PeriodicalId":308,"journal":{"name":"Environment International","volume":"199 ","pages":"Article 109520"},"PeriodicalIF":10.3,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143926682","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}