Environment International最新文献

{"title":"Prenatal and prepubertal exposures to organochlorine compounds and perfluoroalkyl substances and pubertal development at age 12: The PELAGIE cohort study","authors":"Lola Menant, Florence Rouget, Hélène Tillaut, Charline Warembourg, Elke Rouxel, Fabrice Lainé, Éric Gaudreau, Sylvaine Cordier, Ronan Garlantézec, Christine Monfort, Cécile Chevrier","doi":"10.1016/j.envint.2025.109845","DOIUrl":"https://doi.org/10.1016/j.envint.2025.109845","url":null,"abstract":"<h3>Background</h3>Emerging evidence suggests that prenatal and prepubertal exposure to organochlorine compounds (OCs) and perfluoroalkyl substances (PFASs) is associated with children’s reproductive health. This study examines the potential impact of these exposures on pubertal development in 12-year-old children.<h3>Methods</h3>Based on the French PELAGIE mother–child cohort, concentrations of OCs and PFASs were measured in cord blood (from 2003 to 2006) and in blood at age 12 (from 2016 to 2018). Medical staff assessed pubertal development (Tanner stages) at age 12, and girls self-reported age at menarche annually (ages 9–16). Associations between exposures and delayed or earlier pubertal development were analyzed using multinomial logistic and Cox regression models, adjusting for confounders, and using quantile g-computation for compound mixtures.<h3>Results</h3>Among 502 children (250 girls, 252 boys; median age: 12.8 years), prenatal PFUdA exposure in girls was associated with delayed breast development [OR (95 %CI): 2.05 (1.03,4.06)]. In boys, prenatal PFHxS exposure was associated with reduced risk of earlier gonadal development [0.47 (0.26,0.83)], and β-HCH with reduced risks of both delayed [0.66 (0.43,0.99)] and earlier [0.69 (0.48,0.97)] pubic hair development.Prepubertal exposure in girls to HCB, PCBs, and PFASs was associated with increased risk of delayed breast development [e.g., PFOA: 2.53 (1.04,6.12)] and later age at menarche [e.g., ΣPCBs: HR 0.77 (0.61,0.97)]. In boys, prepubertal p,p’-DDE was associated with increased risk of earlier puberty [gonadal development: 1.77 (1.09,2.88); pubic hair growth: 1.56 (1.01,2.44)], while PCB-118 was associated with delayed development. Prepubertal PFASs were associated with reduced risk of earlier puberty [e.g., PFHxS-gonadal stages: 0.39 (0.20,0.75)].In mixture analyses, no associations were observed with regards to prenatal exposure, but prepubertal exposure was associated with delayed pubertal development in girls.<h3>Conclusion</h3>Prenatal and prepubertal exposure to OCs and PFASs may alter pubertal development at age 12 in girls and boys, underscoring the need for further research.","PeriodicalId":308,"journal":{"name":"Environment International","volume":"41 1","pages":""},"PeriodicalIF":11.8,"publicationDate":"2025-10-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145255373","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Protocol for a systematic evidence map of environmental research related to autism spectrum disorders: the aWARE project","authors":"Anisha Singh, Johanna R. Rochester, Robyn Blain, Vickie R. Walker, Katherine E. Pelch, Anthony Hannani, Jeremy Frye, Cindy P. Lawler, Astrid C. Haugen, Amanda E. Garton, Andrew A. Rooney","doi":"10.1016/j.envint.2025.109839","DOIUrl":"https://doi.org/10.1016/j.envint.2025.109839","url":null,"abstract":"<h3>Introduction</h3>Emerging data supporting the potential contribution of environmental chemical exposures to the etiology of autism spectrum disorders (ASD) led to increased interest, research, and publications. This diverse and rapidly growing body of evidence covers a range of study designs, environmental exposures, and ASD-related outcomes. The amount and complexity of research present barriers to identifying, characterizing, and synthesizing relevant evidence to better understand potential associations. The objective of this protocol is to describe a systematic evidence map (SEM) method for identifying and characterizing published scientific research on early-life environmental chemical and physical exposures and ASD or ASD-related outcomes into an interactive resource called aWARE − a Web-based tool for Autism Research and the Environment.<h3>Methods</h3>A comprehensive search for ASD-related studies will be conducted in PubMed, Web of Science, and Scopus, without limits on publication year or language. Eligibility criteria focused on early-life environmental exposure will guide the selection of relevant articles using DistillerSR® and study characteristics will be extracted using DEXTR, a web-based semi-automated data extraction software. Studies will be categorized based on key concepts including major categories of exposure (e.g., air pollution), evidence stream (human, experimental animal), study design, and ASD outcomes, and visualized as SEMs in aWARE a queryable and interactive database created using Tableau. Input from the autism community will be used to guide the scope of this project and format of the SEMs to increase the utility of the tool. The results of the SEMs will also be summarized in a brief narrative format.<h3>Conclusion</h3>This protocol reports pre-specified SEM methods for developing the aWARE tool on ASD and environmental exposures including outreach to the autism community for important input. The resulting project will advance ASD research with the protocol ensuring transparency and replicability.","PeriodicalId":308,"journal":{"name":"Environment International","volume":"54 1","pages":""},"PeriodicalIF":11.8,"publicationDate":"2025-10-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145254940","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Diverse in vitro liver models reveal comprehensive biotransformation pathways of Tetrabromobisphenol A","authors":"Hongrui Zhang, Xingwang Hou, Jiyan Liu, Jiahui Su, Shiyu Li, Weifang Chen, Feng Guo, Guibin Jiang","doi":"10.1016/j.envint.2025.109848","DOIUrl":"https://doi.org/10.1016/j.envint.2025.109848","url":null,"abstract":"Tetrabromobisphenol A is a widely used brominated flame retardant. Its biotransformation in human liver has raised significant environmental and health concerns. This study investigated and compared the metabolism of TBBPA in three <em>in vitro</em> liver models—human liver microsome (HLM), human hepatoblastoma (HepG2) cell, and human normal hepatocyte (MIHA) cell systems. At the end of exposure, 92.4%, 13.6%, and 98.4% of TBBPA was metabolized in HLM, HepG2 cell, and MIHA cell systems, respectively. According to the nontarget analysis, a total of 21 metabolites of TBBPA, including 7 for HLM, 9 for HepG2 cell, and 16 for MIHA, were found. A novel metabolite TBBPA mono-<em>β</em>-<span>d</span>-glucopyranoside mono-<em>β</em>-<span>d</span>-glucuronide was identified for the first time. The metabolism degrees and metabolite types differed significantly across the three <em>in vitro</em> models, which might be related to the different expression and activity of enzymes. By combining these three <em>in vitro</em> models, complex transformation pathways were confirmed, including glucuronidation, deglucuronidation, sulfation, methylation, glycosylation, debromination, coupling elimination reaction, and substitution, contributing to a better understanding of the environmental fate and health risk assessment of TBBPA in human body.","PeriodicalId":308,"journal":{"name":"Environment International","volume":"24 1","pages":""},"PeriodicalIF":11.8,"publicationDate":"2025-10-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145247248","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prenatal green space exposure and child’s cognition: mediation by cord blood IGF1 in the ENVIRONAGE birth cohort","authors":"Anna E. Soerensen, Esmée M. Bijnens, Yinthe Dockx, Dries S. Martens, Hanne Sleurs, Lore Verheyen, Michelle Plusquin, Tim S. Nawrot","doi":"10.1016/j.envint.2025.109849","DOIUrl":"https://doi.org/10.1016/j.envint.2025.109849","url":null,"abstract":"<h3>Background</h3>Green space exposure has been linked to improved cognitive functioning over the life course. We examined whether newborn insulin-like growth factor 1 (IGF1) plays a part in this.<h3>Methods</h3>We measured cord blood plasma IGF1 in 317 mother–child pairs from the ENVIR<em>ON</em>AGE birth cohort. Prenatal green space exposure was assessed within several radii (50–1000 m) around the maternal residence. Multivariable linear regression models were used to associate IGF1 levels with green space exposure. Cognitive functioning was assessed at follow-up at 4 to 6 years of age, using the Cambridge Neuropsychological Test Automated Battery (CANTAB), and converted to components by principal component analysis. Mediation analysis was conducted to examine the relationship between green space exposure and cognitive functioning, with IGF1 as a mediator.<h3>Findings</h3>Prenatal short vegetation (&lt;3 m in height) exposure associated with newborn IGF1 within 50, 100 and 1000 m (P ≤ 0.05), and newborn IGF1 significantly predicted the neurocognitive domain of attention/psychomotor speed during childhood (P &lt; 0.01). Newborn IGF1 significantly mediated the association between prenatal short vegetation exposure and the latencies of the Motor Screening task and the Big/Little Circle task: Per IQR increase in short vegetation within 50 m, the latencies decreased by 0.45 % (95 % CI: −0.986 to −0.047, P = 0.014) and 0.48 % (95 % CI: −1.164 to −0.016, P = 0.044) via IGF1.<h3>Interpretation</h3>Residential surrounding green space during pregnancy may be associated with long-lasting cognitive benefits for the child, mediated through higher cord blood IGF1 protein levels at birth.","PeriodicalId":308,"journal":{"name":"Environment International","volume":"69 1","pages":""},"PeriodicalIF":11.8,"publicationDate":"2025-10-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145254943","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Human liver perfluorooctane sulfonate associates with steatotic liver disease in a sex-dependent manner","authors":"Emily Flam, Viktor Liénard, Violeta Raverdy, Mehdi Derhourhi, Philippe Froguel, Amélie Bonnefond, Philippe Lefebvre, François Pattou, Delphine Eberlé, Joel T. Haas, Bart Staels","doi":"10.1016/j.envint.2025.109838","DOIUrl":"https://doi.org/10.1016/j.envint.2025.109838","url":null,"abstract":"Perfluorooctane sulfonate (PFOS) is a persistent and widespread contaminant found in the environment and, as a consequence, in the human body, and is linked to adverse health effects, including steatotic liver disease (SLD). Human studies on the role of PFOS in SLD have been largely epidemiological, relying on plasma without measuring liver PFOS. However, using plasma PFOS levels to evaluate fatty liver disease is not comprehensive, and the effects of PFOS in human liver have not been described. We investigated the association of PFOS in plasma (P-PFOS) and liver (L-PFOS) with clinical parameters of Metabolic dysfunction-Associated SLD (MASLD) in a large human cohort with obesity and histology-confirmed MASLD. Combining liver RNA-seq and metabolomic data from liver and plasma, we correlated L- and P-PFOS with mRNA transcripts and metabolites to identify dysregulated transcriptional and metabolic pathways. In women, L-PFOS negatively correlated with MASLD prevalence and severity. Conversely, in men, P-PFOS and L-PFOS positively associated with fibrosis. L-PFOS quartile analysis showed potential threshold effects in several histological parameters in men only. In women, L-PFOS negatively correlated with metabolites from pathways implicated in MASLD progression, including diacylglycerol and sphingolipid species. At the gene expression level, L-PFOS correlated negatively with many fibrosis-related genes involved in collagen formation and extracellular matrix organization in women only. Generally, L-PFOS correlated with many disease-relevant variables in women, but with few in men. These correlations in women were opposite the clinical and molecular changes seen in MASLD progression, while the positive correlation between L-PFOS and liver fibrosis in men suggests a positive relationship with liver disease","PeriodicalId":308,"journal":{"name":"Environment International","volume":"20 1","pages":""},"PeriodicalIF":11.8,"publicationDate":"2025-10-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145254941","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impacts of fertilization on metal(loid) transfer from soil to wheat in a long-term fertilization experiment – using 87Sr/86Sr isotopes as metal(loid) tracer","authors":"Robert C. Hill, Aleksandra Pieńkowska, Ines Merbach, Thomas Reitz, E.Marie Muehe, Avner Vengosh","doi":"10.1016/j.envint.2025.109851","DOIUrl":"https://doi.org/10.1016/j.envint.2025.109851","url":null,"abstract":"Fertilizers are widely used to sustain food production but can alter soil chemistry and potentially contribute toxic metal(loid)s to agricultural systems. For the first time, this study examined the occurrence of select metal(loid)s (Zn, Sr, V, As, Cd, Pb, and U) alongside the ⁸⁷Sr/⁸⁶Sr isotope ratio in agricultural soil— both total and mobile pools— and wheat grain. Samples were collected from one of four fertilization treatments— mineral (NPK), organic (manure), combined mineral + organic, and unfertilized controls— within the 120-year Static Fertilization Experiment in Bad Lauchstädt, Germany. Fertilization treatments altered soil pH and organic carbon resulting in mineral fertilization lowering pH and increasing cation mobility (Cd, Zn, Sr), whereas organic fertilization increased pH and enhanced the mobility of non-cationic elements (V, As). These effects translated into higher Cd in mineral-fertilized wheat grain and higher As in mineral + organic wheat grain. Fertilization shifted the ⁸⁷Sr/⁸⁶Sr ratios in soils and wheat grains toward that of the applied fertilizers, with mineral and mineral + organic wheat grains inheriting the triple super phosphate signature (0.70778) and organic wheat grains matching manure (0.70883). The ⁸⁷Sr/⁸⁶Sr ratio in the mobile soil pool was correlated with mobile As, V, and P, demonstrating that the ⁸⁷Sr/⁸⁶Sr ratio reflects both fertilizer source and the mobility of select co-occurring metal(loid)s. Overall, this study demonstrates metal(loid) enrichment in soil and wheat from fertilization and establishes ⁸⁷Sr/⁸⁶Sr ratio as a robust tracer of fertilizer impacts. These findings underscore the need for targeted fertilization strategies to reduce contaminant accumulation in agroecosystems.","PeriodicalId":308,"journal":{"name":"Environment International","volume":"70 1","pages":""},"PeriodicalIF":11.8,"publicationDate":"2025-10-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145247247","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of climate change on PM2.5 formation chemistry, and the associated human health impacts and economic costs in Southeast Asia","authors":"Tingting Fang, Yefu Gu, Jiaying Li, Joseph Sung, Steve Hung Lam Yim","doi":"10.1016/j.envint.2025.109835","DOIUrl":"https://doi.org/10.1016/j.envint.2025.109835","url":null,"abstract":"Climate change poses a significant threat to both the environment and human health. Fine particulate matter (PM_2.5) pollution is one of the major issues affected by climate change, especially in tropical areas such as Southeast Asia. However, the PM_2.5 formation mechanism and the climate-driven impacts on PM_2.5 levels, compositions, human health, and economy in Southeast Asia have yet to be thoroughly assessed. Here we employed regional climate and air quality models to simulate PM_2.5 over Southeast Asia, identifying the PM_2.5 regime in Southeast Asia and analyzing the role of ammonia (NH₃) in the PM_2.5 formation. We then projected PM_2.5 under various Shared Socioeconomic Pathways (SSPs) scenarios, evaluating the impacts of climate change on PM_2.5 and the resultant human health impacts and economic costs. We found that NH₃ reductions had minimal impact on PM_2.5 concentration in Southeast Asia due to the prevalent NH₃-rich conditions in the region. Controlling volatile organic compounds (VOC) and sulfur dioxides (SO₂) is more effective in reducing secondary PM_2.5 in Southeast Asia. Under climate change, the overall PM_2.5 concentration in Southeast Asia is projected to decrease by ∼2–10 % by 2050 under all scenarios, notably for secondary organic aerosol (SOA) levels (∼41–61 %) driven by future warmer climate conditions. The total PM_2.5-attributed premature mortality in Southeast Asia is projected to increase by ∼7 % under SSP126 and ∼10 % under SSP585 by 2050, particularly in Indonesia and Thailand. The increased PM_2.5-attributable premature mortality was estimated to induce an economic loss of $447 and $591 billion (in 2019 USD), respectively, under SSP126 and SSP585 by 2050. Therefore, a more stringent PM_2.5 control policy is essential to mitigate PM_2.5 pollution and the adverse human health impacts and economic costs in Southeast Asia under climate change.","PeriodicalId":308,"journal":{"name":"Environment International","volume":"35 1","pages":""},"PeriodicalIF":11.8,"publicationDate":"2025-10-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145247622","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of fine particulate matter air pollution (PM2·5) on Nigerian children’s performance on tests of cognitive and neurobehavioral development at age seven years","authors":"Susan D. Duncan, Celia Yetunde Adeniyi, Folasayo I. Ayoola, Mihai Giurcanu, Tope Ibigbami, Ryan T. Chartier, Bethann Conover, Mary Nyakato, Dezheng Huo, Oladosu Ojengbede, Adegoke G. Falade, John Olalekan Taiwo, Olatunbosun G. Arinola, Samuel Adekunle, Oluseyi Fatile, Oluwafunmilade Deji-Abiodun, Iyanuoluwa M. Adebanjo, Oluwatimilehin Ojo, Awwal Adetunji, Tanimowo Abraham, Christopher O. Olopade","doi":"10.1016/j.envint.2025.109843","DOIUrl":"https://doi.org/10.1016/j.envint.2025.109843","url":null,"abstract":"<h3>Background</h3>Elevated exposures to fine particulate matter (PM_2·5) air pollution threaten child health and development. Kerosene and biomass cooking fuels are a source of PM_2·5 in sub-Saharan Africa. Potential impacts on child cognitive and neurobehavioral development require investigation.<h3>Methods</h3>In a cross-sectional observational study, September 2021 − March 2023, we assessed cognitive and neurobehavioral development in 208 Nigerian seven-year-old children using the performance-based KABC-II (neurocognition) and two parent questionnaires: VABS-3 (adaptive behavior) and SDQ (psychological adjustment). We collected data on sociodemographic covariates. We conducted 48-hour PM_2·5 (µg/m³) exposure monitoring twice using two RTI MicroPEM™ sensors: indoor (in-home) and personal (body-worn). We examined the relationship between mean PM_2·5 exposures and child developmental assessment scores using multiple linear regression, adjusting for child’s age and sex, mother/caregiver’s age and education, and household wealth.<h3>Findings</h3>A two-fold increase in mean personal PM_2·5 exposures was associated with 3·04-unit lower (95 % CI: −4·62, −1·46; p &lt; 0·001) KABC-II scores and 2·18-unit lower (95 % CI: −4·79, 0·43; p = 0·10) VABS-3 scores, after adjustment for covariates. Children in households using clean fuels scored higher on both assessments, although the differences were not significant after adjustment. Those in households using exclusively polluting fuel had lower KABC-II scores after adjustment (−4·07, 95 % CI: −8·12, −0·02; p = 0·049). We found no associations between PM_2·5 levels or fuel types and SDQ scores.<h3>Interpretation</h3>Elevated personal PM_2·5 exposures during middle childhood are associated with lower developmental assessment scores in Nigerian seven-year-old children. Household use of polluting cooking fuels contributes to these exposures.","PeriodicalId":308,"journal":{"name":"Environment International","volume":"213 1","pages":""},"PeriodicalIF":11.8,"publicationDate":"2025-10-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145247251","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Quantitative assessment of the radon (222Rn) decay product 210Pb in human toenails as a sensitive measure of personalized long-term radon gas exposure history","authors":"Kerri A. Miller, Dustin D. Pearson, Sophie C. Pett, Michael E. Wieser, Aaron A. Goodarzi","doi":"10.1016/j.envint.2025.109781","DOIUrl":"https://doi.org/10.1016/j.envint.2025.109781","url":null,"abstract":"Lung cancer mortality can be lowered through early-diagnostic screening of people demonstrating a ≥1.5 % 6-year risk of tumor development. However, many who develop lung cancer are ineligible for screening (∼40 % of Canadian patients) as they have insufficient tobacco smoking history. Tools to assess individual lung cancer risk based on exposure to other prevalent environmental carcinogens such as radon (²²²Rn) gas are lacking. Here, we explore ultrasensitive quantification of the ²²²Rn decay product ²¹⁰Pb in toenails (n = 39) as an indicator of personalized, long-term radon exposure history. Toenail cuttings from adults inhaling elevated indoor radon in their primary house (average radon = 354.9 Bq/m³) over a mean of 26.5y (equating to 427 mSv radiation dose) contained 0.298 femtograms of ²¹⁰Pb per nanogram of stable Pb. By contrast, only 0.075 femtograms ²¹⁰Pb per nanogram Pb were detected in toenails from low radon exposure controls (28.4 Bq/m³ over 22.5y equating to 22.8 mSv) – a 397 % difference. Notably, elevated radon decay products (0.245 femtograms of ²¹⁰Pb per nanogram Pb) persisted in toenails from highly radon-exposed people (545.6 Bq/m³ over 18.5y equating to 283 mSv) who, up to 6 years prior to toenail collection, had mitigated their primary residence to reduce radon (post-mitigation radon = 28.1 Bq/m³). No differences were detected on the basis of sex, age, tobacco smoking history, or ²¹⁰Pb-rich game meat consumption. These data suggest that toenail ²¹⁰Pb/Pb isotope (amount) ratios show promise for evaluating individualized retrospective radon dosimetry history – an approach that may become helpful to assess non-tobacco lung cancer risk in the future.","PeriodicalId":308,"journal":{"name":"Environment International","volume":"209 1","pages":""},"PeriodicalIF":11.8,"publicationDate":"2025-10-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145241493","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Beyond boundaries: the combined threats of air pollution and rising surface temperatures","authors":"Tenley Weil, Robert M. Tighe, Linda S. Birnbaum","doi":"10.1016/j.envint.2025.109841","DOIUrl":"https://doi.org/10.1016/j.envint.2025.109841","url":null,"abstract":"Anthropogenic activities contribute to global warming. Despite global efforts to limit temperature rise, recent data show temperature targets continue to be exceeded. Furthermore, human activities have substantially increased the number of chemicals in our environment. These chemicals can both exacerbate global warming, and their toxicity can be impacted by a warming climate. This paper explores how rising temperatures and increased exposure to chemical pollutants interact to amplify adverse health outcomes. We examine the synergistic effects of environmental stressors, focusing on air pollution and extreme weather events. Additionally, we highlight how these environmental threats disproportionately affect socially and economically disadvantaged communities, exacerbating existing health disparities. By integrating insights on climate change, pollution, and social inequities, we aim to underscore the importance of understanding the compounding effects of climate change on human health. This understanding will facilitate a holistic approach essential for creating informed policies and interventions that protect both the environment and human health.","PeriodicalId":308,"journal":{"name":"Environment International","volume":"79 1","pages":""},"PeriodicalIF":11.8,"publicationDate":"2025-10-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145229403","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}