Jiwon Oh, Lesliam Quirós-Alcalá, Xuan Li, Kurunthachalam Kannan, Wenjie Lyu, Lyndsay A. Avalos, Emily S. Barrett, Theresa M. Bastain, Jessie P. Buckley, Patricia Cintora, Lisa A. Croen, Anne L. Dunlop, Akhgar Ghassabian, Rima Habre, Julie B. Herbstman, Ixel Hernandez-Castro, Irva Hertz-Picciotto, Donghai Liang, Cindy T. McEvoy, Thomas G. O’Connor, Sheela Sathyanarayana, Susan L. Schantz, Rebecca J. Schmidt, Julie B. Schweitzer, Anne P. Starling, Heather E. Volk, Megan L. Woodbury, Tracey J. Woodruff, Qi Zhao, Yeyi Zhu, Deborah H. Bennett, for the ECHO Cohort Consortium
{"title":"Prenatal exposure to organophosphate ester flame retardants and behavioral outcomes in early childhood in the Environmental influences on Child Health Outcomes (ECHO) cohort","authors":"Jiwon Oh, Lesliam Quirós-Alcalá, Xuan Li, Kurunthachalam Kannan, Wenjie Lyu, Lyndsay A. Avalos, Emily S. Barrett, Theresa M. Bastain, Jessie P. Buckley, Patricia Cintora, Lisa A. Croen, Anne L. Dunlop, Akhgar Ghassabian, Rima Habre, Julie B. Herbstman, Ixel Hernandez-Castro, Irva Hertz-Picciotto, Donghai Liang, Cindy T. McEvoy, Thomas G. O’Connor, Sheela Sathyanarayana, Susan L. Schantz, Rebecca J. Schmidt, Julie B. Schweitzer, Anne P. Starling, Heather E. Volk, Megan L. Woodbury, Tracey J. Woodruff, Qi Zhao, Yeyi Zhu, Deborah H. Bennett, for the ECHO Cohort Consortium","doi":"10.1016/j.envint.2025.109649","DOIUrl":"https://doi.org/10.1016/j.envint.2025.109649","url":null,"abstract":"Prenatal exposure to organophosphate esters (OPEs) has been linked to neurotoxic effects in children; however, epidemiological evidence remains inconclusive. We investigated associations of prenatal OPE exposure with child behaviors.","PeriodicalId":308,"journal":{"name":"Environment International","volume":"100 1","pages":""},"PeriodicalIF":11.8,"publicationDate":"2025-06-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144515914","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Regina Ntsubise Molomo, Adriana Fernandes Veludo, Paola Viglietti, Hannah Wey, Anouk Petitpierre, Christian Lindh, Martin Röösli, Mohamed Aqiel Dalvie, Samuel Fuhrimann
{"title":"Spatiotemporal variability of urinary pesticide biomarker levels in 201 South African children sampled five times over two years","authors":"Regina Ntsubise Molomo, Adriana Fernandes Veludo, Paola Viglietti, Hannah Wey, Anouk Petitpierre, Christian Lindh, Martin Röösli, Mohamed Aqiel Dalvie, Samuel Fuhrimann","doi":"10.1016/j.envint.2025.109651","DOIUrl":"https://doi.org/10.1016/j.envint.2025.109651","url":null,"abstract":"Understanding pesticide exposure variability over time among children is crucial towards understanding potential acute and long-term health effects of pesticides but data is lacking.","PeriodicalId":308,"journal":{"name":"Environment International","volume":"654 1","pages":""},"PeriodicalIF":11.8,"publicationDate":"2025-06-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144515945","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Haitong Zhe Sun , Han Chen , Yijia Tian , Zekun Wang , Juan Zhou , Lina Zhang , Jing Fang , Juan Gao , Kim Robin van Daalen , Lynette P. Shek , Wei Jie Seow , Yuming Guo , Nick Watts , Xiaoxia Bai
{"title":"Synergistic risks of ambient air particulate matter and ozone exposure on low birth weight: An 11-year longitudinal Chinese maternity cohort study","authors":"Haitong Zhe Sun , Han Chen , Yijia Tian , Zekun Wang , Juan Zhou , Lina Zhang , Jing Fang , Juan Gao , Kim Robin van Daalen , Lynette P. Shek , Wei Jie Seow , Yuming Guo , Nick Watts , Xiaoxia Bai","doi":"10.1016/j.envint.2025.109640","DOIUrl":"10.1016/j.envint.2025.109640","url":null,"abstract":"<div><div>Observational epidemiological studies have demonstrated that maternal exposure to air pollution increases the risk of adverse pregnancy outcomes. However, interactions among multiple environmental exposures remain underexplored. In this study, we performed an epidemiological analysis on 147,979 pregnant women recruited from nine provinces in southeastern China between 2013 and 2023, focusing on the risk of low birth weight (LBW). We found that the critical exposure windows for PM<sub>2.5</sub> and ozone (O<sub>3</sub>) extend from six months prior to conception through the end of second trimester, with hazard ratio of HR = 1.152 (95 % confidence interval [CI]: 1.128–1.177) per 10-μg/m<sup>3</sup> incremental PM<sub>2.5</sub> exposure and HR = 1.028 (95 % CI: 1.024–1.031) per 10-ppb increase in O<sub>3</sub>. Our estimates indicate that in 2021, approximately 47,500 (95 % uncertainty interval [UI]: 41,200–53,600) live-born LBW infants nationwide in China could be attributed to ambient air pollution, declining from 79,800 (95 % UI: 71,700–87,900) in 2002. We observed statistically significant synergistic risk effects, neglecting which could lead to an underestimation of 11,600 (95 % UI: 9,300–13,900) LBW cases. Although air pollution-associated LBW burden is decreasing, the rapidly rising LBW prevalence remains a significant public health concern, particularly as China is implementing the “three-child policy”. Therefore, our study offers precisely quantified, evidence-based policy guidance for safeguarding reproductive health.</div></div>","PeriodicalId":308,"journal":{"name":"Environment International","volume":"202 ","pages":"Article 109640"},"PeriodicalIF":10.3,"publicationDate":"2025-06-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144515912","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Stephanie E. Cleland, William Steinhardt, Lucas M. Neas, J.Jason West, Ana G. Rappold
{"title":"Corrigendum to “Urban heat island impacts on heat-related cardiovascular morbidity: A time series analysis of older adults in US metropolitan areas” [Environ. Int. 178 (2023) 108005]","authors":"Stephanie E. Cleland, William Steinhardt, Lucas M. Neas, J.Jason West, Ana G. Rappold","doi":"10.1016/j.envint.2025.109613","DOIUrl":"https://doi.org/10.1016/j.envint.2025.109613","url":null,"abstract":"No Abstract","PeriodicalId":308,"journal":{"name":"Environment International","volume":"21 1","pages":""},"PeriodicalIF":11.8,"publicationDate":"2025-06-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144488831","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Zhe Xu , Dun Li , Qiao Liu , Sheng Li , Yujian Li , Shu Li , Yuhong Bian , Xuan Kan , Yaogang Wang , Jue Liu
{"title":"Global, regional, and national burden of neonatal diseases attributable to fine particulate matter air pollution, 1990–2050","authors":"Zhe Xu , Dun Li , Qiao Liu , Sheng Li , Yujian Li , Shu Li , Yuhong Bian , Xuan Kan , Yaogang Wang , Jue Liu","doi":"10.1016/j.envint.2025.109638","DOIUrl":"10.1016/j.envint.2025.109638","url":null,"abstract":"<div><div>Fine particulate matter (PM<sub>2.5</sub>) air pollution constitutes a significant hazard to the well-being and survival of children everywhere, posing particularly dire risks to neonates. However, the neonatal disease burden attributable to PM<sub>2.5</sub> pollution remains unclear worldwide. Data on neonatal diseases attributable to PM<sub>2.5</sub> pollution were obtained and collected from the Global Burden of Disease Study (GBD) 2021. The main outcome was the age-standardized disability-adjusted life-years (DALYs) rate (ASDR) and age-standardized mortality rate (ASMR) per 100 000 population of neonatal diseases caused by PM<sub>2.5</sub> pollution. These metrics were stratified by sex, region, country, and disease. The correlations, trends, and projections of the burden were also analyzed. Globally, there were approximately 497.0 thousand deaths and 44737.3 thousand DALYs from neonatal diseases caused by PM<sub>2.5</sub> pollution in 2021. From 1990 to 2021, the overall ASDR (1120.4 to 723.1) and ASMR (12.5 to 8.0) showed a downward trend. However, the ASDR of neonatal diseases attributable to PM<sub>2.5</sub> pollution was high in Sub-Saharan Africa (1717.1 to 1235.8) and South Asia (2010.4 to 1148.1), especially regarding household PM<sub>2.5</sub> pollution. The higher ASDR attributable to PM<sub>2.5</sub> pollution was observed in neonatal encephalopathy due to birth asphyxia and trauma and neonatal preterm birth. By 2050, the ASDR of neonatal disease impacts from household PM<sub>2.5</sub> pollution remain persistently high. Neonatal disease burden attributable to PM<sub>2.5</sub> pollution remains a crucial health issue in children. Targeted strategies to improve PM<sub>2.5</sub> air quality and neonatal disease burden are essential.</div></div>","PeriodicalId":308,"journal":{"name":"Environment International","volume":"202 ","pages":"Article 109638"},"PeriodicalIF":10.3,"publicationDate":"2025-06-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144479540","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Mengyi Li , Qiping Fan , Yi Sun , Tarik Benmarhnia , Jiu-Chiuan Chen , Anqi Jiao , John Molitor , David A. Sacks , Jeff M. Slezak , Vicki Y. Chiu , Chantal C. Avila , Darios Getahun , Jun Wu
{"title":"Plant species richness, green spaces, and preterm birth risk in urban areas","authors":"Mengyi Li , Qiping Fan , Yi Sun , Tarik Benmarhnia , Jiu-Chiuan Chen , Anqi Jiao , John Molitor , David A. Sacks , Jeff M. Slezak , Vicki Y. Chiu , Chantal C. Avila , Darios Getahun , Jun Wu","doi":"10.1016/j.envint.2025.109644","DOIUrl":"10.1016/j.envint.2025.109644","url":null,"abstract":"<div><h3>Background</h3><div>Growing evidence suggests that urban biodiversity may influence human health, though this relationship remains incompletely understood. While green spaces have shown beneficial effects on birth outcomes, the specific role of plant species richness has not been investigated in relation to preterm birth (PTB, <37 weeks’ gestation).</div></div><div><h3>Methods</h3><div>Using Kaiser Permanente Southern California electronic health records (2015–2021), we analyzed 232,452 births to examine associations between plant species richness and PTB. Plant species richness was assessed at the maternal neighborhood level, defined using circular buffers of 1.5 km around maternal residences.</div></div><div><h3>Results</h3><div>We found that increased plant species richness was associated with decreased PTB risk (adjusted odds ratio per interquartile range: 0.959, 95 % CI: 0.941, 0.977). The observed association persisted after further adjustment for multiple green space indicators. The proportions of mediation effects attributable to mean temperature during pregnancy ranged from 7.0 % to 7.8 % across plant species diversity indicators. In the subgroup analysis, plant species diversity demonstrated significantly stronger protective associations against PTB among mothers exposed to higher levels of Ozone, high ambient temperatures, and those gave birth during the pandemic period. Conversely, protective associations were more pronounced among mothers with lower NO<sub>2</sub> exposure during pregnancy. Notably, the significant relationship between plant species richness and reduced PTB persisted in pandemic-period analyses after adjusting for COVID-19 infection during pregnancy.</div></div><div><h3>Conclusions</h3><div>Our findings highlight a complex interplay of sociodemographic and environmental factors influencing PTB risks and underscore the critical need for public health interventions that consider the unique attributes of urban green space.</div></div>","PeriodicalId":308,"journal":{"name":"Environment International","volume":"202 ","pages":"Article 109644"},"PeriodicalIF":10.3,"publicationDate":"2025-06-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144479542","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Kendalem Asmare Atalell , Gavin Pereira , Bereket Duko , Sylvester Dodzi Nyadanu , Melissa O’Donnell , Gizachew A Tessema
{"title":"Prenatal and early childhood exposure to biothermal stress and developmental vulnerability at school entry in Western Australia: a population-based cohort study","authors":"Kendalem Asmare Atalell , Gavin Pereira , Bereket Duko , Sylvester Dodzi Nyadanu , Melissa O’Donnell , Gizachew A Tessema","doi":"10.1016/j.envint.2025.109642","DOIUrl":"10.1016/j.envint.2025.109642","url":null,"abstract":"<div><h3>Backgrounds</h3><div>Rising global temperatures, including in Australia, increase biothermal stress. However, the impact of prenatal and childhood exposure to extreme biothermal stress, measured by the Universal Thermal Climate Index (UTCI), on early childhood developmental vulnerability remains unclear. This study aimed to examine the association between prenatal and early childhood exposure to biothermal stress and early childhood developmental vulnerability at school entry in Western Australia.</div></div><div><h3>Methods</h3><div>A population-based retrospective cohort study of 59,771 children from the 2009–2015 Australian Early Development Census (AEDC) was conducted. UTCI was spatiotemporally linked to maternal residential addresses at the time of birth at the Statistical Area 1 (SA1) level. The average UTCI exposure from conception to AEDC assessment was calculated for each child, with separate analyses for prenatal (conception to birth) and postnatal (birth to AEDC assessment) exposure. Mixed-effect logistic regression models were used to examine the association between childhood developmental vulnerability and biothermal stress.</div></div><div><h3>Result</h3><div>The mean UTCI exposure from conception to AEDC assessment was 14.4 ± 2.5 °C. After adjusting for potential confounders, children exposed to heat stress during this period had 29 % higher odds of DV1 (developmentally vulnerable in one or more AEDC domain(s)) than those exposed to optimal thermal conditions (9–26 °C) (OR: 1.29; 95 % CI: 1.05–1.58). Prenatal exposure to heat stress was associated with 34 % higher odds of DV1 (OR: 1.34; 95 % CI: 1.10–1.65).</div></div><div><h3>Conclusion</h3><div>Exposure to heat stress from conception to the AEDC assessment date increases developmental vulnerability, with the strongest effect observed during the prenatal period. Policymakers might integrate heat exposure considerations into maternal and child health strategies to mitigate risks for vulnerable populations.</div></div>","PeriodicalId":308,"journal":{"name":"Environment International","volume":"202 ","pages":"Article 109642"},"PeriodicalIF":10.3,"publicationDate":"2025-06-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144488718","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Navigating the complexity of exposure to multiclass organic pollutants in respirable size-resolved particles and implications for oxidative potential","authors":"Ying-Jie Zhang, Ting-Ting Xu, Yu-Ling Luan, Hui-Min Shen, Ying Guo","doi":"10.1016/j.envint.2025.109646","DOIUrl":"10.1016/j.envint.2025.109646","url":null,"abstract":"<div><div>Chronic exposure to inhalable atmospheric particulate matter is linked to millions of annual premature deaths globally. Yet the sources and factors driving oxidative potential (OP) remain poorly understood, especially regarding the coexistence of multi-organic pollutants. This longitudinal study examined the size-distribution, respiratory deposition efficiency and daily exposure of 41 chemicals covering polycyclic aromatic hydrocarbons (PAHs), brominated flame retardants (BFRs), and phthalates (PAEs), as well as the dithiothreitol-based OP in size-fractioned PM<sub>10</sub> from distinct waste recycling plants in Guangzhou, South China. From September to December 2020, five parallel samples were successively collected within each of the four plants using an eight-stage cascade sampler. The particle size-dependent correlations were explored between co-existing pollutants and acellular OP, with a weighted quantile sum regression model to rank the relative contribution ratios. The ∑<sub>8</sub>PAE levels in PM<sub>10</sub> were 100 and 1000 times higher than those of ∑<sub>16</sub>PAH and ∑<sub>17</sub>BFR respectively, aligning with the exposure outcomes of dermal contact and inhalation pathways. Compounds in the coarse fractions of PM<sub>9.0–10</sub> primarily deposited in the upper respiratory tract, while 37%–73% in pulmonary alveoli were attributed to finer PM<sub>2.1</sub>. The high-molecular-weight PAHs and BFRs in PM<sub>9.0–10</sub> were more effective in enhancing OP generation than PAEs, with benzo[g,h,i]perylene identified as the most potent oxidizing agent with the highest weight (22%). The findings underscore that elevated pollution burden doses may not necessarily represent severe oxidative toxicity, and the targeted prevention strategies are warranted to mitigate oxidative toxicity from respirable particle.</div></div>","PeriodicalId":308,"journal":{"name":"Environment International","volume":"202 ","pages":"Article 109646"},"PeriodicalIF":10.3,"publicationDate":"2025-06-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144479541","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Xuan Chen , Ulrike Gehring , Georgia M.C. Dyer , Kees de Hoogh , Sasha Khomenko , Haneen Khreis , Natalie Mueller , Roel Vermeulen , Harry Williams , Belen Zapata-Diomedi , Mark Nieuwenhuijsen , Gerard Hoek
{"title":"Exposure-response functions of the correlated environmental exposures green space, noise, and air pollution for quantifying mortality burden in health impact assessment","authors":"Xuan Chen , Ulrike Gehring , Georgia M.C. Dyer , Kees de Hoogh , Sasha Khomenko , Haneen Khreis , Natalie Mueller , Roel Vermeulen , Harry Williams , Belen Zapata-Diomedi , Mark Nieuwenhuijsen , Gerard Hoek","doi":"10.1016/j.envint.2025.109645","DOIUrl":"10.1016/j.envint.2025.109645","url":null,"abstract":"<div><h3>Objective</h3><div>Environmental health impact assessments (HIA)<!--> <!-->on green space, air pollution (fine particulate matter (PM<sub>2.5</sub>) or nitrogen dioxide (NO<sub>2</sub>)), and noise use exposure–response functions (ERF) based on single-exposure models from epidemiological studies, not accounting for potential confounding by other commonly correlated exposures. We assessed differences in ERFs between single- and multi-exposure models for calculation of joint health impacts in HIA.</div></div><div><h3>Methods</h3><div>We systematically searched cohort studies that reported both single- and multi-exposure models for associations of long-term exposure to any combination of the following exposures green space, PM<sub>2.5</sub>, NO<sub>2</sub>, and noise, with all-cause mortality. For each exposure, pooled hazard ratios (HRs) were calculated by meta-analyses and compared between single- and two-exposure models. The joint effects of two exposures in each exposure pair were expressed as joint HRs calculated by multiplying the individual HRs. Coefficient differences were calculated, and population attributable fractions (PAF) were used to estimate joint health impacts.</div></div><div><h3>Results</h3><div>Eleven studies were identified, examining associations between multiple exposures and mortality in the general population. The studies show substantial variability in exposure levels and correlations between exposures. For most exposure pairs, adjusting for a second exposure resulted in moderately attenuated HRs compared to single-exposure models. The mortality PAFs estimated from joint single-exposure model HRs were higher than those from two-exposure models, indicating an overestimation of mortality burden when not accounting for other co-exposures. For example, when adjusted for green space or noise, the mortality HRs for PM<sub>2.5</sub> were attenuated from 1.071 to 1.061 and 1.072 to 1.055, respectively. As for PAFs, for the green space-PM<sub>2.5</sub> pair, the single-exposure model PAF (0.090) was 18.4% higher than the two-exposure model (0.076). For all exposure pairs, the joint PAFs of two-exposure models were higher than the PAFs from the single-exposure models for each exposure individually.</div></div><div><h3>Conclusion</h3><div>The pooled coefficient differences from this study can be used to adjust single-exposure ERFs from meta-analyses and allow the calculation of combined impacts from multiple environmental exposures, making HIA estimates more robust and realistic.</div></div>","PeriodicalId":308,"journal":{"name":"Environment International","volume":"202 ","pages":"Article 109645"},"PeriodicalIF":10.3,"publicationDate":"2025-06-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144479670","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Feng Han , Ziwei Pei , Bing Lyu , Xin Zhang , Jian Zhang , Jiaying Liu
{"title":"Modifying effects of vitamin D on associations between per- and polyfluoroalkyl substances exposure and risk of gestational diabetes mellitus: A prospective cohort study in Beijing, China","authors":"Feng Han , Ziwei Pei , Bing Lyu , Xin Zhang , Jian Zhang , Jiaying Liu","doi":"10.1016/j.envint.2025.109641","DOIUrl":"10.1016/j.envint.2025.109641","url":null,"abstract":"<div><div>Epidemiology studies suggested that exposure to Per- and Polyfluoroalkyl Substances (PFAS) might elevate the incidence of Gestational Diabetes Mellitus (GDM), but no study considered the modifying roles of vitamin D, an important nutrient related to GDM development. Thus, this study evaluated the modifying effects of maternal vitamin D on correlations of PFAS exposure with GDM by conducting a cohort study in Beijing, China. We recruited 111 pregnant women who had either one or more high risk factors for GDM in Beijing, China, in 2022. Blood samples collected from pregnant women in 11–13 gestational weeks were analyzed to detect 19 PFAS and 25-hydroxy vitamin D. GDM was confirmed via the Oral Glucose Tolerance Test (OGTT). All subjects were classed as possessing sufficient, insufficient, or deficient vitamin D concentrations. Vitamin D deficiency status was observed to be a significant modifier for associations between GDM risk and PFAS exposure, as well as continuous glucose concentrations in an OGTT (interaction <em>p</em>-value < 0.05). For women with vitamin D deficiency, exposure to five long-chain perfluoroalkyl carboxylates significantly elevated the GDM risk (<em>p</em> < 0.05), and the overall estimated risk ratio for GDM associated with 1 ng/mL increases in PFAS ranged from 3.750 to 8.097. The results suggested that adequate supplementation of vitamin D during early pregnancy could prevent the elevated risk of GDM caused by PFAS exposure.</div></div>","PeriodicalId":308,"journal":{"name":"Environment International","volume":"202 ","pages":"Article 109641"},"PeriodicalIF":10.3,"publicationDate":"2025-06-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144488484","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}