Environment International最新文献

{"title":"Human kinetics of glyphosate: Controlled exposure data supporting the development of a physiologically-based kinetic model for reverse dosimetry","authors":"Nina C. Wieland,&nbsp;Noa Dominicus,&nbsp;Jonatan Dias,&nbsp;Hans Mol,&nbsp;Ad M.J. Ragas,&nbsp;Paul T.J. Scheepers,&nbsp;Frans G.M. Russel","doi":"10.1016/j.envint.2026.110487","DOIUrl":"10.1016/j.envint.2026.110487","url":null,"abstract":"<div><div>Glyphosate is a widely used non-selective herbicide to control weeds, and also used as desiccant before harvest. This study aimed to integrate human kinetic data into a physiologically-based pharmacokinetic (PBK) model to improve risk assessment through reverse dosimetry.</div><div>Kinetics were investigated in a human volunteer study following oral or dermal administration of glyphosate. Glyphosate and its metabolite, aminomethylphosphonic acid (AMPA), were analyzed in plasma, urine, and feces over a period of 96 h. Following oral exposure, peak plasma concentrations were reached at 2.5 h, while urinary concentrations peaked at 161 µg/L after 13 h. Fecal analysis indicated a substantial unabsorbed fraction, and dermal exposure resulted in minimal systemic uptake reflected by low urinary and blood plasma levels. The urinary excretion kinetics observed here are consistent with previously published findings.</div><div>Using these data, a PBK model was developed and validated using an external dataset. Reverse dosimetry was then applied to an independent oral dosing study, accurately reconstructing the administered doses with a maximum deviation of 0.4-fold.</div><div>While the model demonstrates high accuracy and utility for population biomonitoring, uncertainties about glyphosate kinetics remain. Knowledge gaps include glyphosate’s interaction with blood proteins and its ionization behavior at physiological pH, which makes it difficult to predict distribution to bone tissue. Despite these limitations, this human dosing study advances the understanding of glyphosate kinetics and provides a validated PBK model capable of converting urinary biomonitoring data into accurate dose estimates, thereby improving the accuracy of glyphosate risk assessment.</div></div>","PeriodicalId":308,"journal":{"name":"Environment International","volume":"215 ","pages":"Article 110487"},"PeriodicalIF":10.2,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148885823","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"PFAS internal exposure levels across two generations and endocrine-metabolic biomarker associations in women from the French E3N-Generations cohort","authors":"Francesca Romana Mancini,&nbsp;Claire Perrin,&nbsp;Régine Billmann,&nbsp;Hélène Blanché,&nbsp;Pauline Frénoy,&nbsp;Xuan Ren,&nbsp;Grégoire Petitjean,&nbsp;Ronan Pommereuil,&nbsp;German Cano-Sancho,&nbsp;Bruno Le Bizec,&nbsp;Jean-Philippe Antignac,&nbsp;Gianluca Severi","doi":"10.1016/j.envint.2026.110462","DOIUrl":"10.1016/j.envint.2026.110462","url":null,"abstract":"<div><h3>Background</h3><div>Per- and polyfluoroalkyl substances (PFAS) are environmentally persistent chemicals suspected to act as endocrine-active compounds, disrupting lipid metabolism and hormonal homeostasis, while possible multigenerational effects are an emerging concern. Although legacy PFAS such as perfluorooctane sulfonic acid (PFOS) and perfluorooctanoic acid (PFOA) have been restricted in France since 2009, the impact of these measures on long-term exposure remains unclear.</div></div><div><h3>Objectives</h3><div>We aimed to (1) compare serum PFAS concentrations across two generations of adult French women and identify determinants of exposure; (2) evaluate associations between PFAS (individually and as mixtures) and early hormonal and metabolic biomarkers; and (3) explore potential intergenerational associations between maternal PFAS exposure and adult daughters’ biomarkers.</div></div><div><h3>Methods</h3><div>We analyzed serum PFAS concentrations among two generations of women from the E3N-Generations cohort (1995–1999 and 2024). Biomarkers included thyroid-stimulating hormone (TSH), testosterone, sex hormone–binding globulin (SHBG), triglycerides, and total, HDL, and LDL cholesterol. Multivariable models assessed determinants of exposure and PFAS–biomarker associations, with exploratory analyses of maternal–daughter pairs.</div></div><div><h3>Results</h3><div>Total PFAS concentrations decreased substantially over time, particularly for PFOS and PFOA, although these compounds remained the predominant PFAS detected in both generations. Sociodemographic, anthropometric, and reproductive factors were associated with PFAS serum concentrations, with generation-specific patterns. The results showed a positive cumulative association between PFAS and testosterone and a negative association with TSH and HDL cholesterol, while associations with other lipid biomarkers were heterogeneous. No consistent associations were observed between maternal PFAS concentrations and adult daughters’ biomarkers.</div></div><div><h3>Conclusions</h3><div>Despite regulatory-driven declines, PFAS exposure remains widespread and associated with endocrine and metabolic biomarkers in adult women. These findings are consistent with the need for strengthened, class-based PFAS regulation and dedicated studies to rigorously evaluate potential multigenerational associations.</div></div>","PeriodicalId":308,"journal":{"name":"Environment International","volume":"215 ","pages":"Article 110462"},"PeriodicalIF":10.2,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148755980","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mercury exposure and potential hazards through vegetation intake to large herbivores along an elevational gradient in the Central Himalayas","authors":"Huihui Song,&nbsp;Yiming Hu,&nbsp;Ruiping Luo,&nbsp;Huina Lin,&nbsp;Zuxiu Yao,&nbsp;Yizhu Yan,&nbsp;Liuxuan Lv,&nbsp;Yaning Zhang,&nbsp;Wei Zhang,&nbsp;Wu Chen,&nbsp;Yanju Ma,&nbsp;Veerle L.B. Jaspers,&nbsp;Lihai Shang","doi":"10.1016/j.envint.2026.110460","DOIUrl":"10.1016/j.envint.2026.110460","url":null,"abstract":"<div><div>Vegetation in mountains offers specific habitats for endemic wildlife while serving as a sink for long-range transported pollutants such as mercury (Hg). Over half of the atmospheric Hg is absorbed by vegetation, making it a major pathway for Hg transfer into terrestrial ecosystems. As one of the world’s 22 biodiversity hotspots and situated between the major Hg emitters in Asia, the Himalayas host numerous endemic and endangered species, including large herbivores that play vital ecological roles. We investigated total Hg (THg) in vegetation across five vegetation zones along the longest elevational gradient (1800 <span><math><mrow><mo>∼</mo></mrow></math></span> 5400 m) in the Central Himalayas. Mean vegetation THg was 20.2 ± 10.7 ng g⁻¹ (6.0 <span><math><mrow><mo>∼</mo></mrow></math></span> 62.9 ng g⁻¹, 60 sampling sites). Overall, vegetation THg decreased significantly with elevation (<em>y = (−0.004 ± 0.001) x + (33.5 ± 4.8)</em>, <em>R</em> ² = 0.13, <em>p</em> = 0.005), with soil THg explaining the variation most. We found 6 herbivore species inhabiting evergreen broad-leaved forest and 10 species inhabiting subalpine coniferous forest, could be facing potential Hg exposure risk in those vegetation zones. When we combine this with captive daily intake estimation of vegetation, we identified endangered high-altitude species, such as Himalayan tahr (<em>Hemitragus jemlahicus</em>) and kiang (<em>Equus kiang</em>), which could be more at Hg exposure risk under climate change due to potential habitat shrinkage. Our findings highlight that, in addition to predators, large herbivores may also face elevated Hg exposure risk due to their substantial consumption of vegetation, which is important when evaluating the Minamata Convention’s effectiveness.</div></div>","PeriodicalId":308,"journal":{"name":"Environment International","volume":"215 ","pages":"Article 110460"},"PeriodicalIF":10.2,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148811715","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"From environmental toxicology to integrated environmental health: understanding environmental change, chemical complexity and health in a changing world","authors":"Frederic Coulon,&nbsp;Hong Chen,&nbsp;Hefa Cheng,&nbsp;Kyungho Choi,&nbsp;Albert Juhasz,&nbsp;Xiaobo Liu,&nbsp;Yang Song,&nbsp;Hao Zhu","doi":"10.1016/j.envint.2026.110454","DOIUrl":"10.1016/j.envint.2026.110454","url":null,"abstract":"","PeriodicalId":308,"journal":{"name":"Environment International","volume":"215 ","pages":"Article 110454"},"PeriodicalIF":10.2,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148705033","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Novel and rigorous methods for identifying cancer hazards: The updated Report on Carcinogens Handbook","authors":"RM. Lunn,&nbsp;WD. Arroyave,&nbsp;N. Guha,&nbsp;ST. Atwood,&nbsp;W. Bisson,&nbsp;D. Cuomo,&nbsp;AD. Ewens,&nbsp;SC. Garner,&nbsp;M.E. Hodgson,&nbsp;GD. Jahnke,&nbsp;ME. Marder,&nbsp;AF. Peters,&nbsp;AA. Rooney,&nbsp;PJ. Schwingl,&nbsp;A. Wang,&nbsp;SS. Mehta","doi":"10.1016/j.envint.2026.110517","DOIUrl":"10.1016/j.envint.2026.110517","url":null,"abstract":"<div><div>Cancer hazard identification is the first step in preventing cancer. Robust and transparent methods for rigorous interrogation of published research are vital for a high-quality assessment of the scientific evidence resulting in cancer hazard identification. The National Toxicology Program publishes cancer hazard assessments for possible listing in the Report on Carcinogens (RoC), which are conducted using a four-part systematic review (SR) process described in the RoC Handbook. This Handbook provides guidance for developing a substance-specific evaluation framework, assessing study informativeness, evaluating and integrating data across studies within each evidence stream (e.g., human, experimental animal, and mechanistic studies) and then integrating across evidence streams to reach a cancer hazard conclusion.</div><div>The recently updated RoC Handbook incorporates advances in SR methods and provides an updated suite of tools, approaches, and resources to ensure scientific rigor, transparency, and confidence in conclusions reached in cancer hazard evaluations. The most significant advancements include a new fit-for-purpose SR strategy and guidance for assessing and integrating evidence from mechanistic studies, including read-across approaches, and clearer approaches for integrating evidence across evidence streams to reach causal conclusions. We also added toolkits for determining the informativeness of human, animal cancer, and mechanistic studies, and resources related to literature search strings, exposure assessment, and information on biomarkers and assays for the Key Characteristics of Carcinogens. These innovations have significantly enhanced the transparency and scientific integrity of RoC cancer hazard assessments and can be used by the scientific community for their own assessments.</div></div>","PeriodicalId":308,"journal":{"name":"Environment International","volume":"215 ","pages":"Article 110517"},"PeriodicalIF":10.2,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148928420","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Health in nationally determined contributions: a policy analysis of 191 countries","authors":"Ana-Catarina Pinho-Gomes,&nbsp;Katherine C. Dibbon,&nbsp;Gabriela Cipriano-Flores,&nbsp;Rachel Hulme,&nbsp;Jessica Gong,&nbsp;Jane Hirst,&nbsp;Alice Witt,&nbsp;Kate Womersley,&nbsp;Celestine Donovan-Bradley,&nbsp;Edward Mullins","doi":"10.1016/j.envint.2026.110473","DOIUrl":"10.1016/j.envint.2026.110473","url":null,"abstract":"<div><h3>Background</h3><div>Nationally Determined Contributions (NDCs) describe the commitments made by each country to reduce its greenhouse gas emissions. Assessing how health is considered in NDCs is critical to understand how countries plan to protect their populations’ health from climate change.</div></div><div><h3>Methods</h3><div>This policy analysis investigated how health was considered by NDCs for 191 countries across seven domains: health co-benefits, health adaptation, health impacts, sustainable healthcare, health inequalities, women, and other. It included quantitative analysis, which summarised the score for each domain, and qualitative analysis using content analysis to identify common themes (i.e., recurring patterns/concepts).</div></div><div><h3>Results</h3><div>The mean of the total score was 4.7 (SD 3.5) points for the first submission, with median of 5 [range 0–12] points. For the second submission, the mean of the total score was 3.2 (SD 3.7) points, with median of 2 [range 0–12] points. The mean of the total score for the third submission was 7.3 (SD 3.2) points, with median of 9 [range 0–13] points. Latin American and Caribbean States achieved the highest scores. Content analysis identified important themes, such as the direct and indirect impacts of climate change on health, the need to adopt bold policies to protect the population with early warning systems and other health protection interventions, the need to build resilient health systems, the co-benefits of transitioning to renewable energy sources, the unequal impact of climate change, and the importance of gender equality and women’s vulnerability.</div></div><div><h3>Conclusions</h3><div>Although health is considered by the NDCs of most countries, this is often superficial and does not capture the entirety of the health impacts and co-benefits. There is a need to consider health across all domains of climate mitigation and adaptation to prevent climate change from widening health inequalities and to inform planning to mitigate negative impacts on population health. Full consideration of health impacts and co-benefits is likely to strengthen the moral and economic cases for nations to prioritise action on climate change and to prevent ideology-based minimisation of the need for action.</div></div>","PeriodicalId":308,"journal":{"name":"Environment International","volume":"215 ","pages":"Article 110473"},"PeriodicalIF":10.2,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148786527","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Source fingerprint-guided species-specific concentration mapping for targeted malodor source management in industrial park","authors":"Manyun Long,&nbsp;Xuejie Shen,&nbsp;Tianqi Feng,&nbsp;Zhan Zhang,&nbsp;Yusheng Qin,&nbsp;Xiangxian Li,&nbsp;Xin Han,&nbsp;Lichao Lu,&nbsp;Zhen Cao,&nbsp;Xue Li,&nbsp;Xiaoxiao Li,&nbsp;Yang Luo,&nbsp;Jingkun Jiang,&nbsp;Wenqing Liu,&nbsp;Zehui Li","doi":"10.1016/j.envint.2026.110470","DOIUrl":"10.1016/j.envint.2026.110470","url":null,"abstract":"<div><div>Malodorous compounds (MCs) feature ultra-low olfactory thresholds, episodic emissions and rapid dispersion, which complicate the analysis of their spatiotemporal behaviors and hinders real-time identification and spatial mapping of individual odorants in industrial park malodor management. Here, we developed a cost-effective sensor array network guided by source-specific emission fingerprints. The network, calibrated in situ using XGBoost models, achieved species-specific, real-time concentration mapping of multiple MCs across a 3 km² industrial park. A standardized protocol integrating olfactory screening and multi-platform instrumental analysis identified trimethylamine, ethanethiol, hydrogen sulfide and ammonia as the dominant MCs. Dedicated sensor arrays were then constructed based on these source-specific signatures and calibrated in situ against co‑located Fourier transform infrared (FTIR) measurements. A high-density monitoring network of 42 monitors equipped with sensor arrays was established, acquiring data at 10-minute intervals. Real-time concentration mapping based on the monitoring network directly linked MCs to their respective sources. Validated by independent mobile FTIR measurements, the network localized hotspots with &lt;150 m deviation. This source fingerprint-guided spatial monitoring network transforms odor management from a complaint-driven response to source-targeted precision monitoring, offering a paradigm for industrial environmental supervision.</div></div>","PeriodicalId":308,"journal":{"name":"Environment International","volume":"215 ","pages":"Article 110470"},"PeriodicalIF":10.2,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148849625","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A novel dual-pathway AhR mechanism underpins cardiac senescence induced by 6PPDQ","authors":"Baoqiang Fu,&nbsp;Jinhao Li,&nbsp;Mingxuan Zhang,&nbsp;Changyi Shang,&nbsp;Yaru Wu,&nbsp;Qian Zhang,&nbsp;Xiaoyu Wu,&nbsp;Bin Jiang,&nbsp;Tao Chen,&nbsp;Yan Jiang","doi":"10.1016/j.envint.2026.110483","DOIUrl":"10.1016/j.envint.2026.110483","url":null,"abstract":"<div><div>N-(1,3-dimethylbutyl)-N’-phenyl-p-phenylenediamine quinone (6PPDQ), an emerging tire-wear-derived environmental pollutant, has been associated with cardiac senescence, though its pathogenic mechanism remains unclear. Using in vitro (differentiated H9c2 cardiomyocytes, mechanistically optimized dose, 500 μg/L) and in vivo (zebrafish, environmentally relevant concentrations, 2 μg/L) models, we demonstrate that 6PPDQ induces cardiac senescence through indoleamine 2,3-dioxygenase 1 (IDO1)/kynurenine-mediated activation of the aryl hydrocarbon receptor (AhR). This process engages two parallel and functionally independent AhR signaling branches. In the canonical genomic pathway, AhR transcriptionally upregulates Cyp1a1, leading to reactive oxygen species overproduction, DNA damage, and ultimately cellular senescence evidenced by an increased proportion of SA-β-galactosidase positive cells, elevated p21 and p16 expression, compromised Lamin B1 integrity, and diminished cardiac function. Concurrently, non-genomic AhR pathway is initiated via Src kinase, which propagates signals through PI3K/AKT. This signaling cascade functionally correlates with transcription factor EB (TFEB) cytoplasmic retention, impairing its nuclear translocation and the subsequent transcription of key autophagy-lysosomal genes such as Lamp1 and Lamp2. Consequently, 6PPDQ disrupts lysosomal biogenesis and autophagic flux, marked by lysosomal depletion, p62 accumulation and defective autophagosome clearance, thereby accelerating cardiac senescence. Importantly, pharmacological inhibition of AhR attenuates DNA damages, facilitates TFEB nuclear translocation, recovers the autophagic flux, thereby mitigating the senescent phenotype induced by 6PPDQ. Reciprocal cross-pathway inhibition further confirmed that these branches do not functionally interact.</div><div>Collectively, our findings delineate a kynurenine-driven, dual-pathway mechanism: genomic (Cyp1a1/ROS/DNA damage) and non-genomic (autophagy-lysosomal disruption) AhR signaling underlying 6PPDQ induced cardiac aging. These results establish AhR as pivotal node in pollutant related cardiovascular aging, offering novel mechanistic insights and potential therapeutic targets.</div></div>","PeriodicalId":308,"journal":{"name":"Environment International","volume":"215 ","pages":"Article 110483"},"PeriodicalIF":10.2,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148856797","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The extractive classroom: indoor school environments as reservoirs of mining legacy","authors":"Nicolás C. Zanetta-Colombo,&nbsp;Manuel Prieto,&nbsp;Carlos A. Manzano,&nbsp;Zoë L. Fleming,&nbsp;Manuel Leiva,&nbsp;Javiera Machuca,&nbsp;Lara Nigro,&nbsp;Camilla Della Torre,&nbsp;Anja Eichler,&nbsp;Petrus le Roux,&nbsp;Johanna R.C. Von Holdt,&nbsp;Alexander Varychev,&nbsp;Lucie Tajcmanova,&nbsp;Leah Chibwe,&nbsp;Javier A. Sánchez-Moreno,&nbsp;Christian Scholz,&nbsp;Stefan Rheinberger,&nbsp;Paola Rubilar,&nbsp;Estela Blanco,&nbsp;Josefa Alarcon-Paredes,&nbsp;Marcus Nüsser","doi":"10.1016/j.envint.2026.110478","DOIUrl":"10.1016/j.envint.2026.110478","url":null,"abstract":"<div><div>The global energy transition is accelerating the demand for copper and other energy-transition minerals worldwide, potentially expanding the existing large-scale mining across the Global South. Sustainability assessments of mining currently focus primarily on ambient outdoor concentrations of chemicals (metals) and commonly assume that buildings can buffer human exposure. Here we test this assumption in Calama, Chile, a desert city downwind of one of the world’s largest copper-mining complexes (Chuquicamata). We combined elemental, isotopic, and mineralogical analyses with oxidative potential measurements and zebrafish embryo assays to examine paired indoor and outdoor settled dust from 38 schools in Calama. Indoor concentrations of Cu, As, Pb, and Mo closely tracked outdoor levels and exceeded regional desert background by up to one order of magnitude, with minimal attenuation for As and Pb. Mineralogical and isotopic evidence indicated that the dust is not connected to fresh vehicles or combustion emissions, but rather to the mining industry. Additionally, the evidence showed enrichment in oxidized mining-derived particles, and indoor dust exhibited substantial oxidative potential. Zebrafish embryos exposed to dust extracts showed elevated heart rate under sublethal conditions. These results indicate that indoor environments in intensive mining landscapes, including classrooms, may be physically integrated into the surrounding extractive environment and should be incorporated into regular environmental monitoring, mine-closure planning, and just-transition governance.</div></div>","PeriodicalId":308,"journal":{"name":"Environment International","volume":"215 ","pages":"Article 110478"},"PeriodicalIF":10.2,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148860230","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prenatal exposure to a mixture of non-persistent endocrine-disrupting chemicals and attention and hyperactivity symptoms in children in the ECHO cohort","authors":"Teresa Herrera,&nbsp;Sara Hyman,&nbsp;Roger Newman,&nbsp;Aisha S. Dickerson,&nbsp;Lesliam Quirós-Alcalá,&nbsp;Deborah H. Bennett,&nbsp;Jiwon Oh,&nbsp;Gredia Huerta-Montañez,&nbsp;Andrea R. Titus,&nbsp;Iván Díaz,&nbsp;Deborah J. Watkins,&nbsp;Leonardo Trasande,&nbsp;Brennan H. Baker,&nbsp;Assiamira Ferrara,&nbsp;Andrea E. Cassidy-Bushrow,&nbsp;Marnie Hazlehurst,&nbsp;Akhgar Ghassabian,&nbsp;for the Environmental influences on Child Health Outcomes (ECHO) Cohort Consortium","doi":"10.1016/j.envint.2026.110488","DOIUrl":"10.1016/j.envint.2026.110488","url":null,"abstract":"<div><h3>Objective</h3><div>To examine the association between prenatal exposure to a mixture of EDCs and attention-deficit/hyperactivity disorder (ADHD) symptoms in children.</div></div><div><h3>Methods</h3><div>Participating were mother–child pairs from the Environmental influences on Child Health Outcomes (ECHO) Cohort (n = 3,962, 18 Sites, 2001–2021). Maternal spot urine samples collected during pregnancy were sent to the Wadsworth Center Human Health Exposure Analysis Resource laboratory and analyzed using a single assay workflow. From those samples, 24 urinary metabolites of EDCs with detection frequency &gt; 70%, were grouped as molar sum of high- and low-molecular-weight phthalates, polycyclic aromatic hydrocarbons, bisphenol S, organophosphate esters, and organophosphate and pyrethroid pesticides. Child ADHD symptoms were assessed using raw scores from the Child Behavior Checklist for preschool-aged (CBCL/1½-5) and school-aged (CBCL/6–18) Attention-Deficit/Hyperactivity Problems subscale. Scores ≥ the 85th and 95th percentiles were respectively classified as borderline and clinical thresholds. Quantile g-computation estimated the expected change in ADHD outcome associated with a one-quartile increase in all prenatal EDC mixture concentrations, using negative binomial models for raw scores and binomial models for percentile thresholds.</div></div><div><h3>Results</h3><div>Prenatal exposure to the EDC mixture was not associated with child ADHD symptoms in preschool-aged or school-aged children in adjusted models for either continuous raw scores or percentile thresholds.</div></div><div><h3>Conclusion</h3><div>Overall our findings on prenatal EDC mixture exposure and ADHD symptoms were not robust to full adjustment. Future research that can delineate factors such as windows of vulnerability and trajectories of ADHD-related symptoms may help clarify mixed findings in the literature.</div></div>","PeriodicalId":308,"journal":{"name":"Environment International","volume":"215 ","pages":"Article 110488"},"PeriodicalIF":10.2,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148883853","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}