Environment International最新文献

{"title":"Recycling process of decoration and demolition waste is a neglected source for emerging concerns in particulate phase: PAHs as an example","authors":"Nana Zang ,&nbsp;Pinjing He ,&nbsp;Hua Zhang ,&nbsp;Xiaoxing Zhang ,&nbsp;Fan Lü","doi":"10.1016/j.envint.2025.109393","DOIUrl":"10.1016/j.envint.2025.109393","url":null,"abstract":"<div><div>Decoration and demolition waste (DDW) has been widely studied because of its annual surge in output, complex composition, and high utilization potential. DDW recycling is a key element of circular economy, with the potential for emerging pollutants in the particulate phase. Thus, this study selected polycyclic aromatic hydrocarbons (PAHs) as the representative and investigated their emission characteristics and occupational risk in the particulate phase, including 2.5-μm (PM_2.5), inhalable (PM₁₀), total suspended particles (TSP), and dust samples of different sizes (75–100 μm, 50–75 μm, and &lt; 50 μm), from dust collectors during DDW recycling. Acenaphthylene (Acy), chrysene (Chr), benz[a]anthracene (BaA), fluoranthene (Fla), pyrene (Pyr), phenanthrene (Phe) were detected in all samples. PM_2.5 and dust in 75–100 μm own the highest total occupation risk of 1.51 × 10^-13 and 2.07 × 10^-15, respectively. Chr and BaA had the control priority with the converted toxicity of 162.82 ng/g and 233.35 ng/g. Moreover, nontarget screening was applied to mining out isophorone, benzophenone, and other carcinogenic micropollutants in the PM_2.5, PM₁₀, TSP, and dust samples. Global PAHs from DDW recycling production can reach 193.44 ± 241.80 kg/a under reasonable estimation. This study provides strong evidence that DDW recycling is a neglected source of concern in the particulate phase.</div></div>","PeriodicalId":308,"journal":{"name":"Environment International","volume":"198 ","pages":"Article 109393"},"PeriodicalIF":10.3,"publicationDate":"2025-03-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143703344","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparison of air pollution exposure assessment methods and the association with children’s respiratory health","authors":"Femke Bouma ,&nbsp;Gerard Hoek ,&nbsp;Gerard H. Koppelman ,&nbsp;Judith M. Vonk ,&nbsp;Nicole AH Janssen ,&nbsp;Sjoerd van Ratingen ,&nbsp;Wouter Hendricx ,&nbsp;Joost Wesseling ,&nbsp;Jules Kerckhoffs ,&nbsp;Roel Vermeulen ,&nbsp;Kees de Hoogh ,&nbsp;Ulrike Gehring","doi":"10.1016/j.envint.2025.109407","DOIUrl":"10.1016/j.envint.2025.109407","url":null,"abstract":"<div><h3>Introduction</h3><div>Epidemiological studies of the associations of long-term exposure to outdoor air pollution with asthma onset and lung function in children have used different exposure assessment methods. Little is known about how these different methods affect the magnitude of the effect estimates. The aim of this study was to compare associations of long-term air pollution exposures, estimated with different exposure assessment methods, with asthma incidence and lung function.</div></div><div><h3>Methods</h3><div>Eight exposure assessment methods, differing in modelling (dispersion, empirical) and monitoring strategy (fixed site, mobile), were applied to estimate annual average air pollution levels at the residential addresses of 3,687 participants of the Dutch PIAMA birth cohort. Associations of air pollution exposure with asthma and lung function were assessed and compared between methods. Heterogeneity in the associations was assessed with meta-analyses.</div></div><div><h3>Results</h3><div>Estimated exposure levels and contrasts differed substantially between methods. Exposure estimates from the different methods were moderately to highly correlated, with Pearson correlations ranging from 0.5 to 0.9. Higher air pollution levels were consistently associated with higher asthma incidence and lower FEV₁. However, the magnitude of the association differed between methods (e.g. the ORs (95 % CI) for asthma incidence ranged from 1.09 (0.99; 1.21) to 2.56 (1.50; 4.36) for BC per 1 µg/m³ increment).</div></div><div><h3>Conclusion</h3><div>Different air pollution exposure assessment methods resulted in consistent conclusions about the presence and direction of associations with asthma incidence and lung function in children, but associations differed in magnitude. Differences in exposure assessment methods may partially drive heterogeneity in associations between different studies.</div></div>","PeriodicalId":308,"journal":{"name":"Environment International","volume":"198 ","pages":"Article 109407"},"PeriodicalIF":10.3,"publicationDate":"2025-03-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143703211","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical impact of air pollution on SPECT myocardial perfusion imaging","authors":"Océane Bouchot ,&nbsp;Stephan Gabet ,&nbsp;Loïc Djaileb ,&nbsp;Aurélia Robin ,&nbsp;Nicolas De Leiris ,&nbsp;Julie Roux ,&nbsp;Laurent Riou ,&nbsp;Gerald Vanzetto ,&nbsp;Daniel Fagret ,&nbsp;Catherine Ghezzi ,&nbsp;Rémy Slama ,&nbsp;Gilles Barone-Rochette","doi":"10.1016/j.envint.2025.109406","DOIUrl":"10.1016/j.envint.2025.109406","url":null,"abstract":"<div><h3>Background</h3><div>Air pollution contributes to cardiovascular morbimortality. Air pollution effects on cardiovascular function assessed from non-invasive and invasive imaging have been reported but never on myocardial perfusion. This study aimed to characterize relations of air pollution exposure to myocardial perfusion imaging (MPI).</div></div><div><h3>Methods</h3><div>Patients referred to SPECT (single-photon emission computed tomography) MPI were prospectively enrolled between 2017 and 2020. Myocardial ischemia was assessed from the SPECT. Moderate-to-severe ischemia was defined as a &gt; 10 % ischemic myocardium. Exposures to particulate matter (PM_2.5 and PM₁₀) and NO₂ at the home address were characterized <em>via</em> a 10-meter resolution air pollutant-dispersion model and air quality monitoring system data. Associations of exposures with scintigraphy parameters were assessed through multivariable regressions, and potential modifying effects by sex and BMI were investigated.</div></div><div><h3>Results</h3><div>A total of 1,585 participants were prospectively included (mean age 67.7 ± 11.6 years, 63.3 % male); 148 (9.3 %) patients presented a moderate-to-severe ischemia. In multivariate analysis, the odds of moderate-to-severe ischemia was increased, with adjusted odds-ratio (ORa) of 1.39 [95 % confidence interval (95 % CI): 1.07–1.80; <em>p</em> = 0.013], 1.33 (95 % CI: 1.01–1.75; <em>p</em> = 0.042), and 1.22 (95 % CI: 0.96–1.57; <em>p</em> = 0.10) for each increase of one Interquartile Range (IQR) in PM_2.5, PM₁₀ and NO₂ exposure, respectively (IQR equal to 3.3, 4.3 and 10.0 µg/m³, respectively). With further adjustment for cardiometabolic diseases and symptoms, only the association with PM_2.5 remained statistically significant: ORa 1.34 (95 % CI: 1.03–1.75, <em>p</em> = 0.031) for each one-IQR increase. Associations with PM₁₀ and PM_2.5 tended to be stronger in women (interaction <em>p</em>-value equal to 0.11 and 0.077, respectively).</div></div><div><h3>Conclusion</h3><div>We provide new insights into a mechanism by which particulate air pollution may influence cardiovascular risk. Exposure to PM was associated with moderate-to-severe ischemia, particularly in women.</div></div>","PeriodicalId":308,"journal":{"name":"Environment International","volume":"198 ","pages":"Article 109406"},"PeriodicalIF":10.3,"publicationDate":"2025-03-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143675320","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Advancing non-target analysis of emerging environmental contaminants with machine learning: Current status and future implications","authors":"Alexa Canchola ,&nbsp;Lillian N. Tran ,&nbsp;Wonsik Woo ,&nbsp;Linhui Tian ,&nbsp;Ying-Hsuan Lin ,&nbsp;Wei-Chun Chou","doi":"10.1016/j.envint.2025.109404","DOIUrl":"10.1016/j.envint.2025.109404","url":null,"abstract":"<div><div>Emerging environmental contaminants (EECs) such as pharmaceuticals, pesticides, and industrial chemicals pose significant challenges for detection and identification due to their structural diversity and lack of analytical standards. Traditional targeted screening methods often fail to detect these compounds, making non-target analysis (NTA) using high-resolution mass spectrometry (HRMS) essential for identifying unknown or suspected contaminants. However, interpreting the vast datasets generated by HRMS is complex and requires advanced data processing techniques. Recent advancements in machine learning (ML) models offer great potential for enhancing NTA applications. As such, we reviewed key developments, including optimizing workflows using computational tools, improved chemical structure identification, advanced quantification methods, and enhanced toxicity prediction capabilities. It also discusses challenges and future perspectives in the field, such as refining ML tools for complex mixtures, improving inter-laboratory validation, and further integrating computational models into environmental risk assessment frameworks. By addressing these challenges, ML-assisted NTA can significantly enhance the detection, quantification, and evaluation of EECs, ultimately contributing to more effective environmental monitoring and public health protection.</div></div>","PeriodicalId":308,"journal":{"name":"Environment International","volume":"198 ","pages":"Article 109404"},"PeriodicalIF":10.3,"publicationDate":"2025-03-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143675363","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Combination of suspect and nontarget screening with exposure assessment for per- and polyfluoroalkyl substance prioritization in Chinese municipal wastewater","authors":"Hongxin Mu ,&nbsp;Ling Chen ,&nbsp;Rong Zhou ,&nbsp;Luyao Gu ,&nbsp;Yue Yu ,&nbsp;Jin Tang ,&nbsp;Houhu Zhang ,&nbsp;Hongqiang Ren ,&nbsp;Bing Wu ,&nbsp;Yuanqing Bu","doi":"10.1016/j.envint.2025.109384","DOIUrl":"10.1016/j.envint.2025.109384","url":null,"abstract":"<div><div>Municipal wastewater treatment plants (WWTPs) are significant sources of per- and polyfluoroalkyl substances (PFASs) in aquatic environments, making their identification and priority rank crucial for risk control. Wastewater samples were collected from 148 municipal WWTPs in China to determine the occurrence and risk prioritization of PFASs. A total of 61 PFASs were identified, including 14 legacy and 47 emerging PFASs, using machine learning prediction-enhanced suspect and nontarget screening techniques. PFASs were detected in all wastewater samples, with perfluorocarboxylic acid (PFCA), perfluorosulfonic acid (PFSA), fluoromeric sulfonic acid (FTSA), and perfluoroalkyl sulfonamide-like (PFSM) substances being the predominant classes. The exposure loads of legacy and emerging PFASs to the Chinese population were 71.8 and 52.9 μg·day⁻¹·people⁻¹, respectively, and textile and clothing products might be the primary PFAS exposure pathways. Through a risk prioritization method integrating toxicity and exposure data, ten legacy and five emerging PFASs were flagged as high-priority substances requiring additional attention. As the PFAS risk removal efficiency by conventional biological treatment processes was only 0.7 %, the PFAS risk priority patterns in influent and effluent were similar (<em>r</em> = 0.86, <em>p</em> &lt; 0.01). In addition, there were significant regional differences in the PFAS risk distribution, and the PFAS risk in eastern China was higher than that in other regions. This study offers novel insights for the identification and priority control assessment of PFASs and other emerging environmental contaminants.</div></div>","PeriodicalId":308,"journal":{"name":"Environment International","volume":"198 ","pages":"Article 109384"},"PeriodicalIF":10.3,"publicationDate":"2025-03-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143675364","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exploring the interaction between ambient air pollution and road traffic noise on stroke incidence in ten Nordic cohorts","authors":"Huyen Nguyen Thi Khanh ,&nbsp;Massimo Stafoggia ,&nbsp;Mette Sørensen ,&nbsp;Aslak Harbo Poulsen ,&nbsp;Ole Raaschou-Nielsen ,&nbsp;Jibran Khan ,&nbsp;Jørgen Brandt ,&nbsp;Anja Olsen ,&nbsp;Zorana Jovanovic Andersen ,&nbsp;Mette Kildevaeld Simonsen ,&nbsp;Youn-Hee Lim ,&nbsp;Jiawei Zhang ,&nbsp;Thomas Cole-Hunter ,&nbsp;Göran Pershagen ,&nbsp;Andrei Pyko ,&nbsp;Agneta Åkesson ,&nbsp;Leonard Stockfelt ,&nbsp;Eva M. Andersson ,&nbsp;Mikael Ögren ,&nbsp;David Segersson ,&nbsp;Jeroen de Bont","doi":"10.1016/j.envint.2025.109403","DOIUrl":"10.1016/j.envint.2025.109403","url":null,"abstract":"<div><h3>Introduction</h3><div>Ambient air pollution and road traffic noise are stroke risk factors, but evidence on their potential joint effects remains limited. This study investigated the independent and joint associations of air pollution and road traffic noise on stroke incidence using both multiplicative and additive scales.</div></div><div><h3>Methods</h3><div>We followed stroke incidence in ten cohorts in Sweden, Denmark, and Finland. We modelled annual average levels of outdoor particulate matter &lt; 2.5 µm (PM_2.5), nitrogen dioxide (NO₂) and road traffic noise at residential addresses. We applied Cox proportional hazards regression to evaluate their single association. We assessed multiplicative interaction with interaction terms in Cox models and additive interaction using the Relative Excess Risk due to Interaction method.</div></div><div><h3>Results</h3><div>We followed 136,897 adults for 20 years, and 8.0 % experienced stroke incidence. PM_2.5, NO₂ and road traffic noise were associated with higher stroke risk in single-exposure models. Multiplicative models showed higher HRs between PM_2.5 and stroke at higher levels of noise and vice versa: HRs per 5 μg/m³ of PM_2.5 were 1.06 (95 % CI:0.94–1.21) at 40 dB and 1.11 (95 % CI:0.85–1.44) at 80 dB of road traffic noise; HRs per 12 dB of road traffic noise were 1.06 (95 % CI:1.01–1.11) at 4 μg/m³ and 1.17 (95 % CI:0.82–1.68) at 48 μg/m³ of PM_2.5. Additive models showed that the combined association of PM_2.5 and road traffic noise was 4 % (RERI = 0.04 (95 % CI:-0.05;1.12)) higher than the sum of their individual association.</div></div><div><h3>Conclusion</h3><div>PM_2.5 and road traffic noise showed a non-significant synergistic association on stroke incidence.</div></div>","PeriodicalId":308,"journal":{"name":"Environment International","volume":"198 ","pages":"Article 109403"},"PeriodicalIF":10.3,"publicationDate":"2025-03-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143672779","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Nuclear hormone receptors control fundamental processes of human fetal neurodevelopment: Basis for endocrine disruption assessment","authors":"Katharina Koch ,&nbsp;Kevin Schlüppmann ,&nbsp;Saskia Hüsken ,&nbsp;Louisa Merit Stark ,&nbsp;Nils Förster ,&nbsp;Stefan Masjosthusmann ,&nbsp;Jördis Klose ,&nbsp;Arif Dönmez ,&nbsp;Ellen Fritsche","doi":"10.1016/j.envint.2025.109400","DOIUrl":"10.1016/j.envint.2025.109400","url":null,"abstract":"<div><div>Despite growing awareness of endocrine disrupting chemicals (EDCs), knowledge gaps remain regarding their effects on human brain development. EDC risk assessment focuses primarily on EATS modalities (estrogens, androgens, thyroid hormones, and steroidogenesis), overlooking the broader range of hormone receptors expressed in the developing brain. This limits the evaluation of chemicals for their potential to cause endocrine disruption-mediated developmental neurotoxicity (ED-DNT). The Neurosphere Assay, an in vitro test method for developmental neurotoxicity (DNT) evaluation, is an integral component of the DNT in vitro testing battery, which has been used to screen a broad domain of environmental chemicals. Here, we define the endocrine-related applicability domain of the Neurosphere Assay by assessing the impact and specificity of 14 hormone receptors on seven key neurodevelopmental processes (KNDPs), neural progenitor cell (NPC) proliferation, migration of radial glia, neurons, and oligodendrocytes, neurite outgrowth, and differentiation of neurons and oligodendrocytes. Comparative analyses in human and rat NPCs of both sexes revealed species- and sex-specific responses. Mechanistic insights were obtained through RNA sequencing and agonist/antagonist co-exposures. Most receptor agonists modulated KNDPs at concentrations in the range of physiologically relevant hormone concentrations. Phenotypic effects induced by glucocorticoid receptor (GR), liver X receptor (LXR), peroxisome proliferator-activated receptor beta/delta (PPARβδ), retinoic acid receptor (RAR) and retinoid X receptor (RXR) activation were counteracted by receptor antagonists, confirming specificity. Transcriptomics highlighted receptor crosstalk and the involvement of conserved developmental pathways (e.g. Notch and Wnt). Species comparisons identified limited concordance in hormone receptor-regulated KNDPs between human and rat NPCs. This study presents novel findings on cellular and molecular hormone actions in human fetal NPCs, highlights major species differences, and illustrates the Neurosphere Assay’s relevance for detecting endocrine MoAs, supporting its application in human-based ED-DNT risk assessment.</div></div>","PeriodicalId":308,"journal":{"name":"Environment International","volume":"198 ","pages":"Article 109400"},"PeriodicalIF":10.3,"publicationDate":"2025-03-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143666046","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ozone-induced lung injury and inflammation: Pathways and therapeutic targets for pulmonary diseases caused by air pollutants","authors":"Remo C. Russo ,&nbsp;Dieudonnée Togbe ,&nbsp;Isabelle Couillin ,&nbsp;Noria Segueni ,&nbsp;Lianyong Han ,&nbsp;Valérie F.J. Quesniaux ,&nbsp;Tobias Stoeger ,&nbsp;Bernhard Ryffel","doi":"10.1016/j.envint.2025.109391","DOIUrl":"10.1016/j.envint.2025.109391","url":null,"abstract":"<div><div>Exposure to ambient Ozone (O₃) air pollution directly causes by its oxidative properties, respiratory epithelial cell injury, and cell death, which promote inflammation and hyperreactivity, posing a significant public health concern. Recent clinical and experimental studies have made strides in elucidating the mechanisms underlying O₃-induced epithelial cell injury, inflammation, and airway hyperreactivity, which are discussed herein. The current data suggest that O₃-induced oxidative stress is a central event-inducing oxeiptotic cell death pathway. O₃-induced epithelial barrier damage and cell death, triggering the release of alarmins and damage-associated molecular patterns (DAMPs), with subsequent endogenous activation of Toll-like receptors (TLRs), DNA sensing pathways, and inflammasomes, activating interleukin-1-Myd88 inflammatory pathway with the production of a range of chemokines and cytokines. This cascade orchestrates lung tissue-resident cell activation in response to O₃ in leukocyte and non-leukocyte populations, driving sterile innate immune response. Chronic inflammatory response to O₃, by repeated exposures, supports a mixed phenotype combining asthma and emphysema, in which their exacerbation by other particulate pollutants potentially culminates in respiratory failure. We use data from lung single-cell transcriptomics to map genes of O₃-damage sensing and signaling pathways to lung cells and thereby highlight potential hotspots of O₃ responses. Deeper insights into these pathological pathways might be helpful for the identification of novel therapeutic targets and strategies.</div></div>","PeriodicalId":308,"journal":{"name":"Environment International","volume":"198 ","pages":"Article 109391"},"PeriodicalIF":10.3,"publicationDate":"2025-03-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143665972","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Periods of susceptibility for associations between phthalate exposure and preterm birth: Results from a pooled analysis of 16 US cohorts","authors":"Alexa Friedman ,&nbsp;Barrett M. Welch ,&nbsp;Alexander P. Keil ,&nbsp;Michael S. Bloom ,&nbsp;Joseph M. Braun ,&nbsp;Jessie P. Buckley ,&nbsp;Dana Dabelea ,&nbsp;Pam Factor-Litvak ,&nbsp;John D. Meeker ,&nbsp;Karin B. Michels ,&nbsp;Vasantha Padmanabhan ,&nbsp;Anne P. Starling ,&nbsp;Clarice R. Weinberg ,&nbsp;Jenny Aalborg ,&nbsp;Akram N. Alshawabkeh ,&nbsp;Emily S. Barrett ,&nbsp;Alexandra M. Binder ,&nbsp;Asa Bradman ,&nbsp;Nicole R. Bush ,&nbsp;Antonia M. Calafat ,&nbsp;Kelly K. Ferguson","doi":"10.1016/j.envint.2025.109392","DOIUrl":"10.1016/j.envint.2025.109392","url":null,"abstract":"<div><h3>Background</h3><div>Phthalate exposure during pregnancy has been associated with preterm birth, but mechanisms of action may depend on the timing of exposure.</div></div><div><h3>Objective</h3><div>Investigate critical periods of susceptibility during pregnancy for associations between urinary phthalate metabolite concentrations and preterm birth.</div></div><div><h3>Methods</h3><div>Individual-level data were pooled from 16 US cohorts (N = 6045, n = 539 preterm births). We examined trimester-averaged urinary phthalate metabolite concentrations. Most phthalate metabolites had 2248, 3703, and 3172 observations in the first, second, and third trimesters, respectively. Our primary analysis used logistic regression models with generalized estimating equations (GEE) under a multiple informant approach to estimate trimester-specific odds ratios (ORs) of preterm birth and significant (p &lt; 0.20) heterogeneity in effect estimates by trimester. Adjusted models included interactions between each covariate and trimester.</div></div><div><h3>Results</h3><div>Differences in trimester-specific associations between phthalate metabolites and preterm birth were most evident for di-2-ethylhexyl phthalate (DEHP) metabolites. For example, an interquartile range increase in mono (2-ethylhexyl) phthalate (MEHP) during the first and second trimesters was associated with ORs of 1.15 (95 % confidence interval [CI]: 0.99, 1.33) and 1.11 (95 % CI: 0.97, 1.28) for preterm birth, respectively, but this association was null in the third trimester (OR = 0.91 [95 % CI: 0.76, 1.09]) (p-heterogeneity = 0.03).</div></div><div><h3>Conclusion</h3><div>The association of preterm birth with gestational biomarkers of DEHP exposure, but not other phthalate metabolites, differed by the timing of exposure. First and second trimester exposures demonstrated the greatest associations. Our study also highlights methodological considerations for critical periods of susceptibility analyses in pooled studies.</div></div>","PeriodicalId":308,"journal":{"name":"Environment International","volume":"198 ","pages":"Article 109392"},"PeriodicalIF":10.3,"publicationDate":"2025-03-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143660637","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Phase-dependent hepatotoxicity of Aluminum oxide nanoparticles mediated through the intestinal microbiota","authors":"Mingshu Li ,&nbsp;Fuchang Deng ,&nbsp;Li Dong ,&nbsp;Xiaona Wang ,&nbsp;Haiyan Jiang ,&nbsp;Siyu Yao ,&nbsp;Yuanyuan Chen ,&nbsp;Lian Duan ,&nbsp;Huamao Du ,&nbsp;Guangqiu Qin ,&nbsp;Song Tang","doi":"10.1016/j.envint.2025.109398","DOIUrl":"10.1016/j.envint.2025.109398","url":null,"abstract":"<div><div>Aluminum oxide (Al₂O₃) nanoparticles (NPs) are extensively utilized in the food industry for applications such as food packaging, antimicrobial coatings, food processing equipment, and additives. Despite their widespread use, the mechanisms underlying Al₂O₃ NP-induced hepatotoxicity and the relationship between their physicochemical properties and toxicity remain inadequately understood. In this study, we explored the hepatotoxic effects of <em>α</em>-Al₂O₃ and <em>γ</em>-Al₂O₃ NPs in rats subjected to oral exposure for 28 days. Employing an integrated metabolomics and microbiome approach, we aimed to elucidate the potential mechanisms involved. Our findings revealed distinct hepatotoxic profiles for <em>α</em>-Al₂O₃ and <em>γ</em>-Al₂O₃ NPs, potentially mediated by differential interactions with the intestinal microbiome. <em>α</em>-Al₂O₃ NPs exhibited reduced hepatotoxicity, as evidenced by minimal liver oxidative stress, which may be associated with the upregulation of digestion-related intestinal flora such as <em>Peptococcaceae</em> and <em>Romboutsia</em>, potentially influencing Al₂O₃ accumulation in the liver. Conversely, <em>γ</em>-Al₂O₃ NPs demonstrated pronounced hepatotoxicity, characterized by liver histopathological changes and elevated levels of alanine aminotransferase, malondialdehyde, and glutathione. This increased toxicity was correlated with alterations in intestinal flora, including <em>Ruminococcaceae</em> and <em>Exiguobacterium</em>, which affected metabolites like L-phenylalanine and arachidonic acid, potentially contributing to hepatotoxicity. The results underscore the importance of the intestinal microbiome in mediating NP-induced toxicity and determining differences in toxicities of different NP phases. This study provides valuable insights into the differential toxicological impacts of Al₂O₃ NP phases, paving the way for safer nanomaterial design and application in the food industry.</div></div>","PeriodicalId":308,"journal":{"name":"Environment International","volume":"198 ","pages":"Article 109398"},"PeriodicalIF":10.3,"publicationDate":"2025-03-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143665971","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}