Environment International最新文献

{"title":"Exposure to the growth promoter tylosin elicits gut microbiota disruption and metabolic imbalance in mouse model","authors":"Hongyuhang Ni ,&nbsp;Jing Wang ,&nbsp;Haoze Wu ,&nbsp;Bill Kwan-wai Chan ,&nbsp;Kaichao Chen ,&nbsp;Han Wang ,&nbsp;Edward Wai-Chi Chan ,&nbsp;Fuyong Li ,&nbsp;Sheng Chen","doi":"10.1016/j.envint.2025.109684","DOIUrl":"10.1016/j.envint.2025.109684","url":null,"abstract":"<div><div>The environmental risk associated with the usage of the antibiotic tylosin as an animal growth promoter (AGPs) needs to be assessed because such agents are used in abundance and contamination of the environment is common, yet their effects on the physiology and gut microbiota composition of animals and humans are poorly understood. In this work, we performed metagenomic analysis and revealed that tylosin significantly disrupted the gut microbiota structure of animals, reduced species diversity, and caused the increase in the relative abundance of <em>Blautia</em> (60.95%). Enrichment of multiple contigs containing ARGs was observed, indicating that tylosin promotes antimicrobial resistance (AMR) development. Transcriptomic analyses of ileum tissues revealed perturbation in gene expression patterns suggestive of mitochondrial dysfunction and energy metabolism imbalance. These alterations might compromise nutrient absorption and utilization in the GI tract, and heighten the risk of development of obesity and non-alcoholic fatty liver disease (NAFLD). Furthermore, downregulation of immune-related gene expression was observed, indicating that tylosin caused immunosuppression and increased susceptibility to microbial infections when used over extended periods. Integrated omics analysis of the liver also showed significant disturbances in metabolism through activation of the arachidonic acid metabolism pathway, exacerbating inflammatory responses, and precipitating the occurrence of metabolic disorders such as type 2 diabetes mellitus (T2DM) and NAFLD. Our findings unveil the detrimental effects of tylosin on animal gut microbiota and metabolic functions and highlight the potential health risks to wildlife and humans when released into the environment. These findings highlight a need for cautious use of AGPs and the development of safer alternatives.</div></div>","PeriodicalId":308,"journal":{"name":"Environment International","volume":"202 ","pages":"Article 109684"},"PeriodicalIF":10.3,"publicationDate":"2025-07-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144622596","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mitochondrial metabolism reprogramming-mediated cardiomyocyte senescence involved in arsenic stress-evoked heart failure","authors":"Yán Wāng ,&nbsp;Yapeng Han ,&nbsp;De-Xiang Xu","doi":"10.1016/j.envint.2025.109686","DOIUrl":"10.1016/j.envint.2025.109686","url":null,"abstract":"<div><div>Chronic exposure to environmental inorganic arsenic is associated with cardiotoxicity, but the underlying mechanisms remain poorly understood. This study investigated how arsenite disrupts mitochondrial metabolism, focusing on the tricarboxylic acid (TCA) cycle, and its role in cardiomyocyte senescence and dysfunction. Proteomics and metabolomics analysis revealed that environmental arsenic exposure altered mitochondrial electron transport chain (ETC) proteins and impaired key enzymes in the TCA cycle, including citrate synthase and succinate dehydrogenase. <em>In vivo</em> drinking exposure to environmental arsenite for six months significantly downregulated mitochondrial metabolic enzymes, leading to disruptions in energy metabolism and cardiac aging. <em>In vitro</em> experiments using AC16 human cardiomyocytes confirmed that environmental arsenite exposure induced early senescence, characterized by increased expression of the aging-related marker <em>CDKN1A</em> and the cardiac injury marker <em>NPPB</em>. Even sub-cytotoxic doses of arsenite impaired mitochondrial TCA cycle function before inducing senescence and injury. Dietary supplementation with nicotinamide mononucleotide (NMN) <em>in vivo</em> and administration with NMN <em>in vitro</em> mitigated cardiomyocyte senescence-associated secretory phenotype and heart failure, suggesting that cardiac aging plays a central role in arsenic-induced functional impairment. Treatment with the mitochondrial antioxidant Mito-TEMPO alleviated these effects, restoring TCA cycle enzyme activity, reducing senescence, and improving cardiomyocyte function across multiple cell generations. These findings suggest that mitochondrial metabolic reprogramming plays a central role in environmental stressor arsenite-induced cardiomyocyte aging and identify mitochondrial metabolism as a potential target to mitigate arsenic-induced cardiac dysfunction.</div></div>","PeriodicalId":308,"journal":{"name":"Environment International","volume":"202 ","pages":"Article 109686"},"PeriodicalIF":10.3,"publicationDate":"2025-07-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144622584","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"From microbiota to metabolism: Unveiling the hidden ecological threat of galaxolide (HHCB) to zebrafish through aquatic microcosm","authors":"Jiaqi Wang ,&nbsp;Fan Wu ,&nbsp;Xusheng Wang ,&nbsp;Shunhao Ai ,&nbsp;Jiayin Xi ,&nbsp;Zhengtao Liu ,&nbsp;Xiaonan Wang","doi":"10.1016/j.envint.2025.109683","DOIUrl":"10.1016/j.envint.2025.109683","url":null,"abstract":"<div><div>The widespread use of Galaxolide (HHCB) and its environmental persistence and bioaccumulation potential pose risks to both the environment and living organisms. This study integrates an innovative aquatic microcosm experimental platform with multi-omics techniques to explore the ecological toxicity of HHCB, simulating aquatic ecosystems and assessing its impacts on zebrafish. The results indicate that HHCB, whether at environmentally relevant concentrations (0.1, 2.5 μg/L) or at higher levels (62.5 μg/L), significantly alters the diversity and composition of the zebrafish gut microbiota, suggesting that HHCB may promote more complex interactions within microbial communities. HHCB also induces metabolic disturbances in the zebrafish gut, significantly affecting multiple metabolic pathways. Moreover, this impact exhibits a dose-dependent effect, with higher concentrations of HHCB leading to more pronounced disruptions. Integrated analysis reveals a notable correlation between gut microbiota and metabolites. Gene set enrichment analysis (GSEA) further suggests that HHCB may drive dynamic changes in microbial ecological functions by disrupting microbial metabolic processes, thereby increasing the risk of metabolic imbalance. This study suggests that HHCB induces metabolic disorders in zebrafish through its multiple effects on gut microbiota and metabolic functions. By leveraging the aquatic microcosm approach, the study offers a more realistic simulation of environmental conditions, providing critical insights into the mechanisms by which HHCB affects gut microbiota and metabolism in aquatic organisms. The findings contribute new scientific evidence for assessing the ecological risks of environmental pollutants.</div></div>","PeriodicalId":308,"journal":{"name":"Environment International","volume":"202 ","pages":"Article 109683"},"PeriodicalIF":10.3,"publicationDate":"2025-07-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144622583","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Revisiting the association between transportation noise and heart disease reported in the World Health Organization Environmental Noise Guidelines for the European Region: a systematic review and meta-analysis","authors":"Michaela Minkin ,&nbsp;Lisa Woodland ,&nbsp;Owen A. Williams ,&nbsp;Sophie Hamilton ,&nbsp;Anna L. Hansell ,&nbsp;Danielle Vienneau ,&nbsp;Xiangpu Gong ,&nbsp;Benjamin Fenech","doi":"10.1016/j.envint.2025.109667","DOIUrl":"10.1016/j.envint.2025.109667","url":null,"abstract":"&lt;div&gt;&lt;h3&gt;Background&lt;/h3&gt;&lt;div&gt;Whilst the link between long-term exposure to transportation noise and cardiovascular disease has been discussed for several decades, there are still uncertainties in the exact quantitative relationship between the two. A systematic review and &lt;em&gt;meta&lt;/em&gt;-analysis that informed recommendations in the World Health Organization Environmental Noise Guidelines for the European Region included studies published up to 2015. Since then, there has been a rapid increase in publications from epidemiological studies exploring the risk over a larger noise exposure range, and with more precise exposure assignment. Given the influential nature of the WHO Guidelines, we investigated whether the inclusion of studies published up to December 2023 changes the quantitative relationship.&lt;/div&gt;&lt;/div&gt;&lt;div&gt;&lt;h3&gt;Methods&lt;/h3&gt;&lt;div&gt;We carried out a systematic review and &lt;em&gt;meta&lt;/em&gt;-analysis on the association between transportation noise (road, rail, and aircraft) and heart disease, specifically ischaemic heart disease (ICD-10 I20-25), atrial fibrillation (ICD-10 I48) and heart failure (ICD-10 I50). We followed the same methodology (search terms, inclusion criteria, risk of bias evaluation and assessment of the quality of evidence) of the WHO systematic review. Pooled effect estimates were calculated for road, railway, aircraft and mixed noise sources using random effects models. For road traffic noise we investigated potential sources of between-study heterogeneity using &lt;em&gt;meta&lt;/em&gt;-regression. We also explored the potential effect of noise exposure assignment precision on the effect estimates.&lt;/div&gt;&lt;/div&gt;&lt;div&gt;&lt;h3&gt;Results&lt;/h3&gt;&lt;div&gt;Fifty-three studies were included in the systematic review: 85 % investigated associations for road, 23 % for rail and 30 % for aircraft noise exposure. The papers spanned 15 countries, with the majority (87 %) of studies investigating populations within European countries. In total 35 studies were included in the &lt;em&gt;meta&lt;/em&gt;-analyses for heart disease incidence, 28 for mortality and five for prevalence. We found positive associations between long-term exposure to road traffic and aircraft noise and heart disease incidence (relative risk (RR) = 1.02 [95 % confidence interval (CI),1.01 to 1.04]; RR = 1.03 [0.99 to 1.07], per 10 dB increase in L&lt;sub&gt;den&lt;/sub&gt;, respectively) and between long-term road, rail and aircraft noise exposure and heart disease mortality (RR = 1.03 [ 1.01 to 1.05]; RR = 1.02 [1.02 to 1.03]; RR = 1.07 [1.01 to 1.14], per 10 dB increase in L&lt;sub&gt;den&lt;/sub&gt;, respectively). The pooled estimates for aircraft noise were attenuated when we excluded small-area studies from the analysis (RR = 1.00 [0.99 to 1.01] for incidence and RR = 1.03 [0.98 to 1.07] for mortality). When combining all sources of transport noise, we found similar pooled effect estimates for heart disease incidence (RR = 1.03 [1.01 to 1.04]) and mortality (RR = 1.03 [1.02 to 1.05]) per 10 dB L&lt;sub&gt;den&lt;/sub&gt; increase in long-term ","PeriodicalId":308,"journal":{"name":"Environment International","volume":"202 ","pages":"Article 109667"},"PeriodicalIF":10.3,"publicationDate":"2025-07-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144612914","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Personal care product use and risk of adult-onset asthma: Prospective cohort analyses of U.S. Women from the sister study","authors":"Jungeun Lim, Che-Jung Chang, Alexandra J. White, Shelton Lo, Hantao Wang, Gabriel Goodney, Rui Miao, Amisha V. Barochia, Véronique L. Roger, Dale P. Sandler, Jason Y.Y. Wong","doi":"10.1016/j.envint.2025.109681","DOIUrl":"https://doi.org/10.1016/j.envint.2025.109681","url":null,"abstract":"<h3>Background</h3>Population studies have found associations between prenatal exposure to endocrine-disrupting chemicals (EDCs) in personal care products (PCPs) and childhood asthma; however, few have investigated adult-onset asthma. We investigated the associations between commonly used PCPs and the risk of adult-onset asthma in a prospective cohort study of U.S. women.<h3>Methods</h3>We analyzed 39,408 participants from the Sister Study (2003–2009) who self-reported their usage frequency of 41 PCPs in the 12-month period before baseline. In our combined PCP analyses, we used Least Absolute Shrinkage and Selection Operator (LASSO) to select key PCPs that predict the risk of adult-onset asthma. In group-specific analyses, PCPs were aggregated into four product groups (i.e., beauty, everyday hair, hygiene, and skincare products). Subsequently, we conducted latent class analysis to identify groups of individuals with similar patterns of PCP use (e.g., infrequent (reference), moderate, and frequent). Multivariable Cox regression models were used to assess the associations between PCP use and incident adult-onset asthma.<h3>Results</h3>Over an average 12.5-year follow-up, 1,774 incident asthma cases were identified. We found a positive association between combined PCP use and adult-onset asthma risk (moderate users, hazard ratio [HR] = 1.19 (95 % confidence interval (CI):1.05,1.33) and frequent users, HR = 1.19 (95 %CI:1.06,1.34)). In group-specific analyses, moderate (HR = 1.21 (95 % CI:1.07,1.37)) and frequent (HR = 1.22 (95 %CI:1.08,1.38)) users of beauty products had a higher asthma risk, compared to infrequent users. Similar associations were observed for hygiene (moderate: HR = 1.14 (95 %CI:1.01,1.29) and frequent: HR = 1.20 (95 %CI:1.06,1.36)) and skincare products (moderate: HR = 1.21 (95 %CI:1.06,1.38) and frequent: HR = 1.20 (95 %CI:1.06,1.35)).<h3>Conclusions</h3>Our findings suggest that PCP use potentially contributes to future risk of adult-onset asthma among women.","PeriodicalId":308,"journal":{"name":"Environment International","volume":"22 1","pages":""},"PeriodicalIF":11.8,"publicationDate":"2025-07-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144603734","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"How to safeguard soil health against silver nanoparticles through a microbial functional gene-based approach?","authors":"Sandhya Mishra,&nbsp;Xiaodong Yang","doi":"10.1016/j.envint.2025.109680","DOIUrl":"10.1016/j.envint.2025.109680","url":null,"abstract":"<div><div>Silver nanoparticles (AgNPs), a major anthropogenic stressor, can threaten soil health by disrupting vital microbial processes critical to maintaining key soil functions such as nutrient cycling, organic matter decomposition, and soil structure formation. Their safe use demands proactive strategies to preserve soils, a globally essential and non-renewable resource that acts as the ultimate sink for nanoparticles released into ecosystems. As functionally critical components of soil ecosystems, microorganisms warrant central consideration in developing nanotoxicity mitigation strategies. This review establishes a framework for soil health protection through systematic examination of (a) AgNPs-mediated ecotoxicological impacts on soil ecosystems, (b) microbial community tolerance thresholds, and (c) ecosystem functions most vulnerable to AgNPs exposure. Through bibliometric analysis of 61 studies, we synthesized comprehensive data on AgNPs-tolerant/sensitive microbial taxa and functional genes, while highlighting critical research gaps and priority research area. Our assessment identifies the following key challenges in predicting AgNPs ecotoxicity in soil systems: (1) a wide toxicity dose–response range, with significant effects observed even at environmentally relevant concentrations (≤1.0 mg/kg), (2) high microbial taxonomic heterogeneity complicating targeted identification, as most taxa remain unculturable, uncharacterized, or classifiable only at higher taxonomic ranks, and (3) limited knowledge of soil-AgNPs-environment interactions hindering identification of critical factors controlling AgNPs toxicity in soils. We then demonstrate how functional gene analysis can improve toxicity prediction accuracy and identify compromised soil processes. This functional genomics approach outperforms taxonomic characterization in predicting AgNPs impacts on soil health by directly quantifying disturbances to critical ecosystem processes. This framework will guide future research in predicting AgNPs’ impacts on soil microbial functionality and overall soil health, while offering a broadly applicable approach to assess toxicity for other emerging anthropogenic stressors, including engineered nanomaterials, pesticides, microplastics, and other soil contaminants.</div></div>","PeriodicalId":308,"journal":{"name":"Environment International","volume":"202 ","pages":"Article 109680"},"PeriodicalIF":10.3,"publicationDate":"2025-07-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144611461","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A scheme for safety testing and assessment of biochemicals under the EU plant protection products regulation (BiochemPPP-STAS)","authors":"Rosa Criollo, Marie-Noelle Douaiher, Orçun Gürkan, Julie Montagnac, Emmanuelle Bonneris, Hanno Bothe, Siân Ellis, Sara Lamperti, Jyotigna Mehta, Benjamin Rignall, Ursula G. Sauer, Christian Strupp, Seamus Taylor, Michael Werner","doi":"10.1016/j.envint.2025.109675","DOIUrl":"https://doi.org/10.1016/j.envint.2025.109675","url":null,"abstract":"Biochemicals (e.g. substances that originate from nature) are often of lower risk to humans and the environment. Nonetheless, when intended for use as active substances in the European Union (EU), they are subject to the same, extensive data requirements as conventional active substances. This impairs their applicability to support a sustainable agriculture. Here, a Scheme for Safety Testing and Assessment of Biochemicals under the EU Plant Protection Products Regulation (BiochemPPP-STAS) is proposed. The BiochemPPP-STAS provides a flexible approach to identify relevant endpoints and studies, the scientific rationale to justify the waiving of studies that would not contribute to the safety assessment and general advice to prepare a ‘fit-for-purpose’ dossier for approval of the biochemical active substance. If the background exposure to the naturally occurring counterpart of the biochemical active substance is not substantially increased through its agricultural use, there is no relevant exposure and further risk assessments are not needed. Prior to the generation of new data, all available information is retrieved and evaluated to address areas of concern and resulting uncertainties. Preferably, data needs are identified following an iterative process, in close alignment between applicant and authority. A base dataset is generated to determine triggers of concern that require follow up in vertebrate animal intensive studies, which are, thus, only conducted as a last resort. To facilitate its regulatory applicability, the BiochemPPP-STAS has been closely aligned with EU legislation. Nonetheless, it has been designed generically and can be adapted to fulfil the legal requirements implemented in other jurisdictions.","PeriodicalId":308,"journal":{"name":"Environment International","volume":"92 1","pages":""},"PeriodicalIF":11.8,"publicationDate":"2025-07-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144594626","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Antibiotic exposure at environmental concentrations under high-fat diet: Impacts on gut microbiota and metabolism","authors":"Liang Zhao ,&nbsp;Jian Xu ,&nbsp;Xiaowei Li,&nbsp;Saiwa Liu,&nbsp;Jingjing Du,&nbsp;Xi Jia,&nbsp;Zhinan Wang,&nbsp;Lirui Ge,&nbsp;Kexin Cui,&nbsp;Yu Ga,&nbsp;Jianzhong Shen,&nbsp;Xi Xia","doi":"10.1016/j.envint.2025.109679","DOIUrl":"10.1016/j.envint.2025.109679","url":null,"abstract":"<div><div>Antibiotics are ubiquitously present in various environments, and exposure to antibiotics at environmental concentrations is even inevitable. Here, we investigate the impact of environmentally relevant concentrations of Azithromycin (AZI) and Ciprofloxacin (CIP) on the gut microbiota and host metabolism in mice under High-Fat Diet (HFD) conditions, administered via drinking water. Long-term exposure to trace antibiotics was observed to induce significant alterations in the microbial community structure. AZI significantly altered Short-Chain Fatty Acid (SCFA) profiles, markedly increasing acetate, butyrate, and propionate production in both male and female mice. AZI and CIP significantly elevated body weight in male mice and altered serum hormones levels along with the serum metabolic profile. Moreover, antibiotic exposure significantly restructured the microbe-host interactions, encompassing both microbe-SCFA and microbe-metabolite relationships. Notably, Lactobacillus has played an essential role in shaping the overall SCFA profile in female mice exposed to AZI. Our findings indicated that exposure to trace antibiotics in conjunction with HFD elicits distinct effects on the gut microbiota and host metabolism, underscoring the need for further investigation into the potential health risks faced by susceptible populations.</div></div>","PeriodicalId":308,"journal":{"name":"Environment International","volume":"202 ","pages":"Article 109679"},"PeriodicalIF":10.3,"publicationDate":"2025-07-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144594628","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Seasonal and spatial detection of pesticide residues in the ambient air of the Alsace region across different land use conditions","authors":"Dani Khoury ,&nbsp;Supansa Chimjarn ,&nbsp;Olivier Delhomme ,&nbsp;Maurice Millet","doi":"10.1016/j.envint.2025.109677","DOIUrl":"10.1016/j.envint.2025.109677","url":null,"abstract":"<div><div>Pesticide contamination in the atmosphere is an escalating environmental and public health concern, particularly in regions with intensive agricultural activity. This study investigates the distribution of 104 semi- and non-volatile pesticides in the air of the Strasbourg metropolitan area over a two-year period, located in the Alsace region of northeastern France. Using NMC@SiC passive samplers, we assessed pesticide concentrations across six diverse sampling sites—urban, suburban, and rural. A total of 104 pesticide compounds, including 35 fungicides, 43 herbicides, and 26 insecticides, were analyzed, with detection frequencies exceeding 30 % for multiple pesticides. Notably, banned pesticides such as chlorpyrifos (61 %, 0.2–1.2 ng m^-3) and lindane (18 %, 0.1–0.9 ng m^-3) were still present, indicating either illegal use or long-range atmospheric transport. Average total pesticide concentrations varied spatially, with herbicide levels ranging from 3.0 to 6.6 ng m^-3, fungicides from 2.0 to 5.3 ng m^-3, and insecticides showing higher variability between two periods: 3.4–12.6 ng m^-3 (2018–2019) and 1.9–3.4 ng m^-3 (2019–2020). Urban sites consistently exhibited higher pesticide burdens compared to suburban and rural sites. Statistically significant differences were observed between urban and rural zones for fungicides (p = 0.0176) and herbicides (p &lt; 0.05), but not for insecticides. Temporal trends revealed clear seasonality, with higher pesticide concentrations during warmer months, supported by a positive correlation with temperature (r ∼0.5, p &lt; 0.01) and a negative correlation with rainfall (r ∼–0.5 to –0.6, p &lt; 0.01). Principal Component Analysis (PCA) distinguishing high total pesticide events and compositional shifts between fungicide- and insecticide-dominated periods. Back-trajectory confirmed predominant westerly and southwesterly airflows, indicating atmospheric transport from upwind agricultural areas. Risk assessments revealed extremely low chronic hazard quotients (HQ &lt; 10^-3) and lifetime cancer risks (&lt; 10^-6), indicating negligible health risks via inhalation exposure for both adults and children. These findings underscore the pervasive yet low-level nature of atmospheric pesticide contamination in <em>peri</em>-urban agricultural regions and highlight the need for continued monitoring to capture seasonal dynamics and potential regulatory impacts.</div></div>","PeriodicalId":308,"journal":{"name":"Environment International","volume":"202 ","pages":"Article 109677"},"PeriodicalIF":10.3,"publicationDate":"2025-07-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144594627","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Volatile organic compounds from typical industries in North China Plain: emissions, air pollution contribution, health risks, and policy implications","authors":"Jiqi Zhu ,&nbsp;Shoujun Xia ,&nbsp;Hejingying Niu ,&nbsp;Jian Xu ,&nbsp;Yueqian Wang ,&nbsp;Xuena Yu ,&nbsp;Ling Huang ,&nbsp;Kun Zhang ,&nbsp;Yangjun Wang ,&nbsp;Limin Zeng ,&nbsp;Qing Li ,&nbsp;Li Li","doi":"10.1016/j.envint.2025.109673","DOIUrl":"10.1016/j.envint.2025.109673","url":null,"abstract":"<div><div>Volatile Organic Compounds (VOCs) are key precursors of ozone (O₃) and secondary organic aerosols (SOA), which significantly impact air quality, human health, and climate. As China enhances VOCs emissions control, industry-specific strategies integrating emission characteristics, air pollution contribution, health risks and warming potential are urgently needed. This study measured VOCs emissions in 28 typical enterprises across 13 industries in an industrial city in Noth China Plain (NCP) through in-situ sampling to investigate the comprehensive impact of VOCs from industries. The entropy weight method is further utilized to investigate the integrated impacts and identify priorities of VOCs from industrial sectors. Results indicate that: (1) Current emission factors of industrial VOCs diverged substantially, with petrochemical (15.93 kg/t) and pharmaceutical (135 kg/t) industries being the most obvious emission sectors. (2) Chemical composition of VOCs varied across different industries, with surface coating emitting 69 % halogenated hydrocarbons, petrochemicals releasing 58 % aromatics, and pharmaceuticals discharging 53 % oxygenated VOCs (OVOCs). (3) Ozone formation potential peaked in surface coating (351.9 mg/m³, aromatics-driven) and olefin-rich organic chemical processes, while secondary organic aerosol potential was dominated by petrochemical aromatics (5,750 μg/m³). (4) Health risks are high in resin and plastic, pharmaceutical, and petroleum industries, with acrolein (HQ = 0.96) and acetaldehyde (cancer risk = 3.9 × 10^-7) as priority hazards. (5) Based on detected greenhouse-effect VOCs, Freon-12/11 emissions dominated climate impacts (83 %, 467.1 tCO₂-eq) in the petrochemical industry. (6) Entropy-weighted analysis prioritized petroleum for Tier-1 controls. Our results highlight the necessity of industry-specific emission factor revisions, reactivity-oriented controls, and multi-pollutant synergies in policy frameworks to address air quality, health, and climate challenges in the future.</div></div>","PeriodicalId":308,"journal":{"name":"Environment International","volume":"202 ","pages":"Article 109673"},"PeriodicalIF":10.3,"publicationDate":"2025-07-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144587013","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}