Environment International最新文献

{"title":"Revisiting the association between transportation noise and heart disease reported in the World Health Organization Environmental Noise Guidelines for the European Region: a systematic review and meta-analysis","authors":"Michaela Minkin , Lisa Woodland , Owen A. Williams , Sophie Hamilton , Anna L. Hansell , Danielle Vienneau , Xiangpu Gong , Benjamin Fenech","doi":"10.1016/j.envint.2025.109667","DOIUrl":"10.1016/j.envint.2025.109667","url":null,"abstract":"<div><h3>Background</h3><div>Whilst the link between long-term exposure to transportation noise and cardiovascular disease has been discussed for several decades, there are still uncertainties in the exact quantitative relationship between the two. A systematic review and <em>meta</em>-analysis that informed recommendations in the World Health Organization Environmental Noise Guidelines for the European Region included studies published up to 2015. Since then, there has been a rapid increase in publications from epidemiological studies exploring the risk over a larger noise exposure range, and with more precise exposure assignment. Given the influential nature of the WHO Guidelines, we investigated whether the inclusion of studies published up to December 2023 changes the quantitative relationship.</div></div><div><h3>Methods</h3><div>We carried out a systematic review and <em>meta</em>-analysis on the association between transportation noise (road, rail, and aircraft) and heart disease, specifically ischaemic heart disease (ICD-10 I20-25), atrial fibrillation (ICD-10 I48) and heart failure (ICD-10 I50). We followed the same methodology (search terms, inclusion criteria, risk of bias evaluation and assessment of the quality of evidence) of the WHO systematic review. Pooled effect estimates were calculated for road, railway, aircraft and mixed noise sources using random effects models. For road traffic noise we investigated potential sources of between-study heterogeneity using <em>meta</em>-regression. We also explored the potential effect of noise exposure assignment precision on the effect estimates.</div></div><div><h3>Results</h3><div>Fifty-three studies were included in the systematic review: 85 % investigated associations for road, 23 % for rail and 30 % for aircraft noise exposure. The papers spanned 15 countries, with the majority (87 %) of studies investigating populations within European countries. In total 35 studies were included in the <em>meta</em>-analyses for heart disease incidence, 28 for mortality and five for prevalence. We found positive associations between long-term exposure to road traffic and aircraft noise and heart disease incidence (relative risk (RR) = 1.02 [95 % confidence interval (CI),1.01 to 1.04]; RR = 1.03 [0.99 to 1.07], per 10 dB increase in L<sub>den</sub>, respectively) and between long-term road, rail and aircraft noise exposure and heart disease mortality (RR = 1.03 [ 1.01 to 1.05]; RR = 1.02 [1.02 to 1.03]; RR = 1.07 [1.01 to 1.14], per 10 dB increase in L<sub>den</sub>, respectively). The pooled estimates for aircraft noise were attenuated when we excluded small-area studies from the analysis (RR = 1.00 [0.99 to 1.01] for incidence and RR = 1.03 [0.98 to 1.07] for mortality). When combining all sources of transport noise, we found similar pooled effect estimates for heart disease incidence (RR = 1.03 [1.01 to 1.04]) and mortality (RR = 1.03 [1.02 to 1.05]) per 10 dB L<sub>den</sub> increase in long-term ","PeriodicalId":308,"journal":{"name":"Environment International","volume":"202 ","pages":"Article 109667"},"PeriodicalIF":10.3,"publicationDate":"2025-07-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144612914","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Personal care product use and risk of adult-onset asthma: Prospective cohort analyses of U.S. Women from the sister study","authors":"Jungeun Lim, Che-Jung Chang, Alexandra J. White, Shelton Lo, Hantao Wang, Gabriel Goodney, Rui Miao, Amisha V. Barochia, Véronique L. Roger, Dale P. Sandler, Jason Y.Y. Wong","doi":"10.1016/j.envint.2025.109681","DOIUrl":"https://doi.org/10.1016/j.envint.2025.109681","url":null,"abstract":"<h3>Background</h3>Population studies have found associations between prenatal exposure to endocrine-disrupting chemicals (EDCs) in personal care products (PCPs) and childhood asthma; however, few have investigated adult-onset asthma. We investigated the associations between commonly used PCPs and the risk of adult-onset asthma in a prospective cohort study of U.S. women.<h3>Methods</h3>We analyzed 39,408 participants from the Sister Study (2003–2009) who self-reported their usage frequency of 41 PCPs in the 12-month period before baseline. In our combined PCP analyses, we used Least Absolute Shrinkage and Selection Operator (LASSO) to select key PCPs that predict the risk of adult-onset asthma. In group-specific analyses, PCPs were aggregated into four product groups (i.e., beauty, everyday hair, hygiene, and skincare products). Subsequently, we conducted latent class analysis to identify groups of individuals with similar patterns of PCP use (e.g., infrequent (reference), moderate, and frequent). Multivariable Cox regression models were used to assess the associations between PCP use and incident adult-onset asthma.<h3>Results</h3>Over an average 12.5-year follow-up, 1,774 incident asthma cases were identified. We found a positive association between combined PCP use and adult-onset asthma risk (moderate users, hazard ratio [HR] = 1.19 (95 % confidence interval (CI):1.05,1.33) and frequent users, HR = 1.19 (95 %CI:1.06,1.34)). In group-specific analyses, moderate (HR = 1.21 (95 % CI:1.07,1.37)) and frequent (HR = 1.22 (95 %CI:1.08,1.38)) users of beauty products had a higher asthma risk, compared to infrequent users. Similar associations were observed for hygiene (moderate: HR = 1.14 (95 %CI:1.01,1.29) and frequent: HR = 1.20 (95 %CI:1.06,1.36)) and skincare products (moderate: HR = 1.21 (95 %CI:1.06,1.38) and frequent: HR = 1.20 (95 %CI:1.06,1.35)).<h3>Conclusions</h3>Our findings suggest that PCP use potentially contributes to future risk of adult-onset asthma among women.","PeriodicalId":308,"journal":{"name":"Environment International","volume":"22 1","pages":""},"PeriodicalIF":11.8,"publicationDate":"2025-07-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144603734","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"How to safeguard soil health against silver nanoparticles through a microbial functional gene-based approach?","authors":"Sandhya Mishra,&nbsp;Xiaodong Yang","doi":"10.1016/j.envint.2025.109680","DOIUrl":"10.1016/j.envint.2025.109680","url":null,"abstract":"<div><div>Silver nanoparticles (AgNPs), a major anthropogenic stressor, can threaten soil health by disrupting vital microbial processes critical to maintaining key soil functions such as nutrient cycling, organic matter decomposition, and soil structure formation. Their safe use demands proactive strategies to preserve soils, a globally essential and non-renewable resource that acts as the ultimate sink for nanoparticles released into ecosystems. As functionally critical components of soil ecosystems, microorganisms warrant central consideration in developing nanotoxicity mitigation strategies. This review establishes a framework for soil health protection through systematic examination of (a) AgNPs-mediated ecotoxicological impacts on soil ecosystems, (b) microbial community tolerance thresholds, and (c) ecosystem functions most vulnerable to AgNPs exposure. Through bibliometric analysis of 61 studies, we synthesized comprehensive data on AgNPs-tolerant/sensitive microbial taxa and functional genes, while highlighting critical research gaps and priority research area. Our assessment identifies the following key challenges in predicting AgNPs ecotoxicity in soil systems: (1) a wide toxicity dose–response range, with significant effects observed even at environmentally relevant concentrations (≤1.0 mg/kg), (2) high microbial taxonomic heterogeneity complicating targeted identification, as most taxa remain unculturable, uncharacterized, or classifiable only at higher taxonomic ranks, and (3) limited knowledge of soil-AgNPs-environment interactions hindering identification of critical factors controlling AgNPs toxicity in soils. We then demonstrate how functional gene analysis can improve toxicity prediction accuracy and identify compromised soil processes. This functional genomics approach outperforms taxonomic characterization in predicting AgNPs impacts on soil health by directly quantifying disturbances to critical ecosystem processes. This framework will guide future research in predicting AgNPs’ impacts on soil microbial functionality and overall soil health, while offering a broadly applicable approach to assess toxicity for other emerging anthropogenic stressors, including engineered nanomaterials, pesticides, microplastics, and other soil contaminants.</div></div>","PeriodicalId":308,"journal":{"name":"Environment International","volume":"202 ","pages":"Article 109680"},"PeriodicalIF":10.3,"publicationDate":"2025-07-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144611461","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A scheme for safety testing and assessment of biochemicals under the EU plant protection products regulation (BiochemPPP-STAS)","authors":"Rosa Criollo, Marie-Noelle Douaiher, Orçun Gürkan, Julie Montagnac, Emmanuelle Bonneris, Hanno Bothe, Siân Ellis, Sara Lamperti, Jyotigna Mehta, Benjamin Rignall, Ursula G. Sauer, Christian Strupp, Seamus Taylor, Michael Werner","doi":"10.1016/j.envint.2025.109675","DOIUrl":"https://doi.org/10.1016/j.envint.2025.109675","url":null,"abstract":"Biochemicals (e.g. substances that originate from nature) are often of lower risk to humans and the environment. Nonetheless, when intended for use as active substances in the European Union (EU), they are subject to the same, extensive data requirements as conventional active substances. This impairs their applicability to support a sustainable agriculture. Here, a Scheme for Safety Testing and Assessment of Biochemicals under the EU Plant Protection Products Regulation (BiochemPPP-STAS) is proposed. The BiochemPPP-STAS provides a flexible approach to identify relevant endpoints and studies, the scientific rationale to justify the waiving of studies that would not contribute to the safety assessment and general advice to prepare a ‘fit-for-purpose’ dossier for approval of the biochemical active substance. If the background exposure to the naturally occurring counterpart of the biochemical active substance is not substantially increased through its agricultural use, there is no relevant exposure and further risk assessments are not needed. Prior to the generation of new data, all available information is retrieved and evaluated to address areas of concern and resulting uncertainties. Preferably, data needs are identified following an iterative process, in close alignment between applicant and authority. A base dataset is generated to determine triggers of concern that require follow up in vertebrate animal intensive studies, which are, thus, only conducted as a last resort. To facilitate its regulatory applicability, the BiochemPPP-STAS has been closely aligned with EU legislation. Nonetheless, it has been designed generically and can be adapted to fulfil the legal requirements implemented in other jurisdictions.","PeriodicalId":308,"journal":{"name":"Environment International","volume":"92 1","pages":""},"PeriodicalIF":11.8,"publicationDate":"2025-07-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144594626","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Antibiotic exposure at environmental concentrations under high-fat diet: Impacts on gut microbiota and metabolism","authors":"Liang Zhao ,&nbsp;Jian Xu ,&nbsp;Xiaowei Li,&nbsp;Saiwa Liu,&nbsp;Jingjing Du,&nbsp;Xi Jia,&nbsp;Zhinan Wang,&nbsp;Lirui Ge,&nbsp;Kexin Cui,&nbsp;Yu Ga,&nbsp;Jianzhong Shen,&nbsp;Xi Xia","doi":"10.1016/j.envint.2025.109679","DOIUrl":"10.1016/j.envint.2025.109679","url":null,"abstract":"<div><div>Antibiotics are ubiquitously present in various environments, and exposure to antibiotics at environmental concentrations is even inevitable. Here, we investigate the impact of environmentally relevant concentrations of Azithromycin (AZI) and Ciprofloxacin (CIP) on the gut microbiota and host metabolism in mice under High-Fat Diet (HFD) conditions, administered via drinking water. Long-term exposure to trace antibiotics was observed to induce significant alterations in the microbial community structure. AZI significantly altered Short-Chain Fatty Acid (SCFA) profiles, markedly increasing acetate, butyrate, and propionate production in both male and female mice. AZI and CIP significantly elevated body weight in male mice and altered serum hormones levels along with the serum metabolic profile. Moreover, antibiotic exposure significantly restructured the microbe-host interactions, encompassing both microbe-SCFA and microbe-metabolite relationships. Notably, Lactobacillus has played an essential role in shaping the overall SCFA profile in female mice exposed to AZI. Our findings indicated that exposure to trace antibiotics in conjunction with HFD elicits distinct effects on the gut microbiota and host metabolism, underscoring the need for further investigation into the potential health risks faced by susceptible populations.</div></div>","PeriodicalId":308,"journal":{"name":"Environment International","volume":"202 ","pages":"Article 109679"},"PeriodicalIF":10.3,"publicationDate":"2025-07-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144594628","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Seasonal and spatial detection of pesticide residues in the ambient air of the Alsace region across different land use conditions","authors":"Dani Khoury ,&nbsp;Supansa Chimjarn ,&nbsp;Olivier Delhomme ,&nbsp;Maurice Millet","doi":"10.1016/j.envint.2025.109677","DOIUrl":"10.1016/j.envint.2025.109677","url":null,"abstract":"<div><div>Pesticide contamination in the atmosphere is an escalating environmental and public health concern, particularly in regions with intensive agricultural activity. This study investigates the distribution of 104 semi- and non-volatile pesticides in the air of the Strasbourg metropolitan area over a two-year period, located in the Alsace region of northeastern France. Using NMC@SiC passive samplers, we assessed pesticide concentrations across six diverse sampling sites—urban, suburban, and rural. A total of 104 pesticide compounds, including 35 fungicides, 43 herbicides, and 26 insecticides, were analyzed, with detection frequencies exceeding 30 % for multiple pesticides. Notably, banned pesticides such as chlorpyrifos (61 %, 0.2–1.2 ng m^-3) and lindane (18 %, 0.1–0.9 ng m^-3) were still present, indicating either illegal use or long-range atmospheric transport. Average total pesticide concentrations varied spatially, with herbicide levels ranging from 3.0 to 6.6 ng m^-3, fungicides from 2.0 to 5.3 ng m^-3, and insecticides showing higher variability between two periods: 3.4–12.6 ng m^-3 (2018–2019) and 1.9–3.4 ng m^-3 (2019–2020). Urban sites consistently exhibited higher pesticide burdens compared to suburban and rural sites. Statistically significant differences were observed between urban and rural zones for fungicides (p = 0.0176) and herbicides (p &lt; 0.05), but not for insecticides. Temporal trends revealed clear seasonality, with higher pesticide concentrations during warmer months, supported by a positive correlation with temperature (r ∼0.5, p &lt; 0.01) and a negative correlation with rainfall (r ∼–0.5 to –0.6, p &lt; 0.01). Principal Component Analysis (PCA) distinguishing high total pesticide events and compositional shifts between fungicide- and insecticide-dominated periods. Back-trajectory confirmed predominant westerly and southwesterly airflows, indicating atmospheric transport from upwind agricultural areas. Risk assessments revealed extremely low chronic hazard quotients (HQ &lt; 10^-3) and lifetime cancer risks (&lt; 10^-6), indicating negligible health risks via inhalation exposure for both adults and children. These findings underscore the pervasive yet low-level nature of atmospheric pesticide contamination in <em>peri</em>-urban agricultural regions and highlight the need for continued monitoring to capture seasonal dynamics and potential regulatory impacts.</div></div>","PeriodicalId":308,"journal":{"name":"Environment International","volume":"202 ","pages":"Article 109677"},"PeriodicalIF":10.3,"publicationDate":"2025-07-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144594627","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Volatile organic compounds from typical industries in North China Plain: emissions, air pollution contribution, health risks, and policy implications","authors":"Jiqi Zhu ,&nbsp;Shoujun Xia ,&nbsp;Hejingying Niu ,&nbsp;Jian Xu ,&nbsp;Yueqian Wang ,&nbsp;Xuena Yu ,&nbsp;Ling Huang ,&nbsp;Kun Zhang ,&nbsp;Yangjun Wang ,&nbsp;Limin Zeng ,&nbsp;Qing Li ,&nbsp;Li Li","doi":"10.1016/j.envint.2025.109673","DOIUrl":"10.1016/j.envint.2025.109673","url":null,"abstract":"<div><div>Volatile Organic Compounds (VOCs) are key precursors of ozone (O₃) and secondary organic aerosols (SOA), which significantly impact air quality, human health, and climate. As China enhances VOCs emissions control, industry-specific strategies integrating emission characteristics, air pollution contribution, health risks and warming potential are urgently needed. This study measured VOCs emissions in 28 typical enterprises across 13 industries in an industrial city in Noth China Plain (NCP) through in-situ sampling to investigate the comprehensive impact of VOCs from industries. The entropy weight method is further utilized to investigate the integrated impacts and identify priorities of VOCs from industrial sectors. Results indicate that: (1) Current emission factors of industrial VOCs diverged substantially, with petrochemical (15.93 kg/t) and pharmaceutical (135 kg/t) industries being the most obvious emission sectors. (2) Chemical composition of VOCs varied across different industries, with surface coating emitting 69 % halogenated hydrocarbons, petrochemicals releasing 58 % aromatics, and pharmaceuticals discharging 53 % oxygenated VOCs (OVOCs). (3) Ozone formation potential peaked in surface coating (351.9 mg/m³, aromatics-driven) and olefin-rich organic chemical processes, while secondary organic aerosol potential was dominated by petrochemical aromatics (5,750 μg/m³). (4) Health risks are high in resin and plastic, pharmaceutical, and petroleum industries, with acrolein (HQ = 0.96) and acetaldehyde (cancer risk = 3.9 × 10^-7) as priority hazards. (5) Based on detected greenhouse-effect VOCs, Freon-12/11 emissions dominated climate impacts (83 %, 467.1 tCO₂-eq) in the petrochemical industry. (6) Entropy-weighted analysis prioritized petroleum for Tier-1 controls. Our results highlight the necessity of industry-specific emission factor revisions, reactivity-oriented controls, and multi-pollutant synergies in policy frameworks to address air quality, health, and climate challenges in the future.</div></div>","PeriodicalId":308,"journal":{"name":"Environment International","volume":"202 ","pages":"Article 109673"},"PeriodicalIF":10.3,"publicationDate":"2025-07-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144587013","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Droughts and PM2.5 air pollution in California: the roles of wildfires","authors":"Hyung Joo Lee ,&nbsp;Min Young Shin ,&nbsp;Na Rae Kim","doi":"10.1016/j.envint.2025.109678","DOIUrl":"10.1016/j.envint.2025.109678","url":null,"abstract":"<div><div>Although individual relationships between droughts, wildfires, and ambient PM_2.5 air pollution have been reported, the role of wildfires in the pathways from droughts to PM_2.5 remains uncertain. This study investigated the association between droughts, defined by the Standardized Precipitation Evapotranspiration Index (SPEI), and PM_2.5 concentrations in California, U.S., from 2006 to 2020. A generalized linear mixed model showed that PM_2.5 concentrations increased by 1.47 μg/m³ (SE = 0.10; p &lt; 0.0001), on average, as drought conditions intensified by 1 unit of SPEI (lower SPEI values indicating drier conditions and greater drought severity). In stratified analysis, drought-related PM_2.5 increases were larger during wildfire days [3.29 μg/m³ (SE = 0.36)] compared to non-wildfire days [0.97 μg/m³ (SE = 0.08)] per unit decrease in SPEI. The likelihood of wildfire-impacted days increased by 89.9 % [odds ratio (OR) = 1.899] per unit decrease in SPEI, rising with the severity of droughts. On wildfire days, wildfire-induced PM_2.5 increased by 3.11 μg/m³ (SE = 0.33) per unit decrease in SPEI, on average. Wildfires were a crucial contributor to the drought-related PM_2.5 increases, as supported by the decline in the association per unit decrease in SPEI from 3.29 μg/m³ (p &lt; 0.0001) to −0.10 μg/m³ (p = 0.1307) after adjusting for wildfire-induced PM_2.5 during wildfire days. PM_2.5 increases due to droughts and wildfires pose substantial challenges for air quality management because the likelihood of PM_2.5 exceedance days was elevated by wildfires during droughts (OR = 2.978 per unit decrease in SPEI). Understanding the role of wildfires informs air quality management in preparation for future droughts and wildfires.</div></div>","PeriodicalId":308,"journal":{"name":"Environment International","volume":"202 ","pages":"Article 109678"},"PeriodicalIF":10.3,"publicationDate":"2025-07-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144587012","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"PFAS in first-time mothers from Sweden: temporal trends and the impact from fish/seafood consumption and drinking water exposure","authors":"Irina Gyllenhammar ,&nbsp;Jonathan P. Benskin ,&nbsp;Merle Plassmann ,&nbsp;Martin Kruså ,&nbsp;Philip McCleaf ,&nbsp;Pernilla Hedvall Kallerman ,&nbsp;Erik Lampa ,&nbsp;Anders Glynn","doi":"10.1016/j.envint.2025.109671","DOIUrl":"10.1016/j.envint.2025.109671","url":null,"abstract":"<div><div>Per- and polyfluoroalkyl substance (PFAS)-contaminated drinking water has been a significant source of human exposure to PFAS in Uppsala, Sweden. Herein, we investigated temporal trends of PFAS in serum samples collected three weeks after delivery from first-time mothers in Uppsala (1996–2022; n = 869), to determine whether efforts to remediate drinking water contamination have reduced maternal PFAS exposure. In addition, the impact of fish/seafood consumption as an exposure source was evaluated. PFAS were analysed by ultra-high performance liquid chromatography-tandem mass spectrometry (UPLC-MS/MS) and temporal trends were evaluated using adjusted cubic spline models.</div><div>Linear (lin) and branched (br) perfluorooctane sulfonate (PFOS) and perfluoroctanoate (PFOA) showed declining temporal trends, likely due to international regulation and phase-out initiatives. Later initiatives to restrict use and emissions of perfluorononanoate (PFNA), perfluorodecanoate (PFDA) and perfluoroundecanoate (PFUnDA) likely explained the initial increased concentrations by 3–7% per year, up to 2007 or 2010, followed by decreasing trends, on average 2–3% per year. Drinking water contamination was likely responsible for the increase in serum br and lin perfluorohexanesulfonate (PFHxS) concentrations early in the study period, followed by a decline over the last decade associated with remediation of the drinking water contamination around 2012. However, even after remediation, drinking water appeared to contribute to perfluoropentanesulfonate (PFPeS) and PFHxS. Fish/seafood consumption was significantly associated with serum levels of lin PFOS, PFNA, PFDA, and PFUnDA.</div><div>Overall, PFAS exposure among first-time mothers in Uppsala has declined, resulting in a marked reduction in the proportion of mothers exceeding the serum reference value established by the European Food Safety Authority. Nevertheless, 54% of the mothers sampled from 2018 to 2022 still exceeded this level, showing that efforts to reduce PFAS exposure must continue for many years to come.</div></div>","PeriodicalId":308,"journal":{"name":"Environment International","volume":"202 ","pages":"Article 109671"},"PeriodicalIF":10.3,"publicationDate":"2025-07-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144578446","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Unveiling the gut’s plastic predicament: How micro- and nano-plastics drive distinct toxicological pathways in Enchytraeus crypticus","authors":"Xing Li ,&nbsp;Hao Qiu ,&nbsp;Wenxing Li ,&nbsp;Cornelis A.M. Van Gestel ,&nbsp;Chao Jin ,&nbsp;Erkai He","doi":"10.1016/j.envint.2025.109670","DOIUrl":"10.1016/j.envint.2025.109670","url":null,"abstract":"<div><div>The gut microenvironment is crucial for maintaining health of its host. However, there is currently limited mechanistic understanding of how stress from microplastics (MPs) and nanoplastics (NPs) alter this environment and its resulting biotoxicity. Here, we systematically investigated the biological responses — from physiology to pathology and from molecular interactions to phenotypic changes — of the soil invertebrate <em>Enchytraeus crypticus</em> exposed to environmentally relevant concentrations of polystyrene MPs (50 μm) and NPs (100 nm). Exposure in a simulated soil matrix spiked with MPs and NPs differently reshaped the gut microenvironment of the worms due to their distinct gastrointestinal fate, thereby inducing different adverse effects via distinct molecular signaling pathways. The high bioaccumulation potential and prolonged retention of NPs in the gut facilitated their interaction with the gut interface, leading to gut acidification and an overaccumulation of H₂O₂ in gut. As a signal molecule, excessive H₂O₂ activated the TNF signaling pathway, which subsequently perturbed membrane-associated lipid metabolism and compromised gut barrier integrity through apoptosis. Unlike NPs, MP accumulation in the gut stimulated mucus secretion as a protective mechanism against physical damage, but disrupted fat digestion and absorption pathways, ultimately inducing cell aging through cardiolipin-mediated mitochondrial dysfunction alongside abnormal lipid droplet accumulation. Collectively, our findings provide mechanistic insights into the different biological and molecular responses to MPs and NPs within the context of an altered enchytraeid gut microenvironment.</div></div>","PeriodicalId":308,"journal":{"name":"Environment International","volume":"202 ","pages":"Article 109670"},"PeriodicalIF":10.3,"publicationDate":"2025-07-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144578447","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}