Environment International最新文献

{"title":"Gestational exposure to particulate matter from urban wildfires is associated with changes in circulating oxylipins but not flame retardants 7 to 13 months post-exposure","authors":"Eunyoung Park, Qing Shen, Zhichao Zhang, Claire E. O’Brien, Amanda J. Goodrich, Elizabeth E. Angel, Irva Hertz-Picciotto, Daniel J. Tancredi, Sean Raffuse, Deborah H. Bennett, Rebecca J. Schmidt, Ameer Y. Taha","doi":"10.1016/j.envint.2025.109468","DOIUrl":"https://doi.org/10.1016/j.envint.2025.109468","url":null,"abstract":"Exposure to fine particulate matter (PM_2.5) from wildfire smoke has been linked to immune dysregulation underlying multiple health conditions, but data on the long-term effects of these exposures during gestation are lacking. Smoke PM_2.5 from wildfires occurring in urban areas is of particular concern because it can carry persistent chemicals within household furniture or soil, as well as polyaromatic hydrocarbons (PAHs) from combusted materials. The present study investigated the long-term associations between wildfire PM_2.5 and serum polybrominated diphenyl ethers (PBDEs), polychlorinated biphenyls (PCBs), PAHs and lipid mediators (i.e., oxylipins) involved in immune regulation in participants from the B-SAFE (Bio-Specimen Assessment of Fire Effects) study, which enrolled women pregnant during or shortly after the 2017 Tubbs Fire in California (n = 140). Serum samples were collected and assayed 7 to 13 months post-exposure, at which point 20 women were still pregnant and 120 women were postpartum. Adjusted linear regression models revealed a significant positive association between increasing PM_2.5 (μg/m³) exposure and serum concentrations of benzo[k]fluoranthene, a PAH (β = 0.866, <em>P</em> = 0.0403, [95 %CI: 0.0389, 1.69]). No associations were observed between PM_2.5 exposure and serum PBDEs, PCBs or other PAHs. Increased exposure to PM_2.5 was associated with lower serum concentrations of lipoxygenase (LOX)-derived free oxylipins and increased concentrations of LOX-derived oxylipins esterified to circulating lipids. These findings provide new evidence of long-term effects of gestational wildfire PM_2.5 exposure on the turnover of oxylipins involved in inflammation and vasoconstriction via the LOX pathway. Additional studies are warranted to better understand the impact of these changes on maternal and child health.","PeriodicalId":308,"journal":{"name":"Environment International","volume":"137 1","pages":""},"PeriodicalIF":11.8,"publicationDate":"2025-04-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143853215","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Antimicrobial effects, and selection for AMR by non-antibiotic drugs in a wastewater bacterial community","authors":"April Hayes ,&nbsp;Lihong Zhang ,&nbsp;Edward Feil ,&nbsp;Barbara Kasprzyk-Hordern ,&nbsp;Jason Snape ,&nbsp;William H Gaze ,&nbsp;Aimee K Murray","doi":"10.1016/j.envint.2025.109490","DOIUrl":"10.1016/j.envint.2025.109490","url":null,"abstract":"<div><div>Antimicrobial resistance (AMR) is a major threat to human, animal, and crop health. AMR can be directly selected for by antibiotics, and indirectly co-selected for by biocides and metals, at environmentally relevant concentrations. Some evidence suggests that non-antibiotic drugs (NADs) can co-select for AMR, but previous work focused on exposing single model bacterial species to predominately high concentrations of NADs. There is a significant knowledge gap in understanding a range of NAD concentrations, (including lower µg/L concentrations found in the environment) on mixed bacterial communities containing a diverse mobile resistome. Here, we determined the antimicrobial effect and selective potential of diclofenac, metformin, and 17-β-estradiol, NADs that are commonly found environmental pollutants, in a complex bacterial community using a combination of culture based, metagenome, and metratranscriptome approaches. We found that diclofenac, metformin, and 17-β-estradiol at 50 µg/L, 26 µg/L, and 24 µg/L respectively, significantly reduced growth of a bacterial community although only 17-β-estradiol selected for an AMR marker using qPCR (from 7 µg/L to 5400 µg/L). Whole metagenome sequencing indicated that there was no clear selection by NADs for antibiotic resistance genes, or effects on community composition. Additionally, increases in relative abundance of some specific metal resistance genes (such as <em>arsB</em>) were observed after exposure to diclofenac, metformin, and 17-β-estradiol. These results indicate that environmentally relevant concentrations of NADs are likely to affect community growth, function, and potentially selection for specific metal resistance genes.</div></div>","PeriodicalId":308,"journal":{"name":"Environment International","volume":"199 ","pages":"Article 109490"},"PeriodicalIF":10.3,"publicationDate":"2025-04-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143853115","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluating inhalation risks and toxicological impacts of lithium-ion battery thermal runaway emissions","authors":"Maureen Meister ,&nbsp;Shaligram Sharma ,&nbsp;Xiaojia He ,&nbsp;Patrick S. Chepaitis ,&nbsp;Taryn Waddey ,&nbsp;Mark Wilson ,&nbsp;Vinay Premnath ,&nbsp;Judith Jeevarajan ,&nbsp;Marilyn Black ,&nbsp;Christa Wright","doi":"10.1016/j.envint.2025.109466","DOIUrl":"10.1016/j.envint.2025.109466","url":null,"abstract":"<div><div>The occurrence of thermal runaway (TR) events continues to rise as the need for lithium-ion batteries (LIB) for energy storage increases. However, the inhalation risks associated with LIB TR events remain widely unknown. The objective of this study was to evaluate the impact of LIB TR particulate emission exposures on primary small airway epithelial cells (SAEC). TR was triggered by subjecting lithium-ion cells to thermal abuse at different states of charge (SOC). Two different battery cathode chemistry compositions, namely, nickel manganese cobalt (NMC) or lithium iron phosphate (LFP) were evaluated. Aerosol monitoring and sampling instrumentation were employed followed by physicochemical particle characterization and inhalation dosimetry modeling. SAEC were treated with TR particulate emission extracts for 24 h and 7 days at doses representing a cumulative 1- and 5-year inhalation exposure. Following treatment, cellular viability, reactive oxygen species (ROS) production, and protein expression of DNA damage and epithelial mesenchymal transition (EMT) markers were assessed. TR particulate emissions consisted of ultrafine particles containing a variety of heavy metals. Cellular senescence was induced by NMC-derived TR extracts, but not LFP-derived TR extracts. SAEC treated with the 5-year dose of NMC-derived TR extract, induced significant ROS production. In cells treated with NMC-derived TR extract, regulators of DNA repair and cell cycle arrest were perturbed. Oxidative stress subsequently induced EMT, as SAEC treated with NMC-derived TR particulate emissions reduced E-cadherin expression and upregulated Fascin and Vimentin expression. This study reveals the respiratory implications of TR particulate emissions and the role of battery chemistry.</div></div>","PeriodicalId":308,"journal":{"name":"Environment International","volume":"199 ","pages":"Article 109466"},"PeriodicalIF":10.3,"publicationDate":"2025-04-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143853858","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A comprehensive assessment of non-indigenous species requires the combination of multi-marker eDNA metabarcoding with classical taxonomic identification","authors":"Stefano Varrella ,&nbsp;Silvia Livi ,&nbsp;Cinzia Corinaldesi ,&nbsp;Luca Castriota ,&nbsp;Teresa Maggio ,&nbsp;Pietro Vivona ,&nbsp;Massimo Pindo ,&nbsp;Sebastiano Fava ,&nbsp;Roberto Danovaro ,&nbsp;Antonio Dell’Anno","doi":"10.1016/j.envint.2025.109489","DOIUrl":"10.1016/j.envint.2025.109489","url":null,"abstract":"<div><div>In marine environment, non-indigenous species (NIS) can alter natural habitats and cause biodiversity loss with important consequences for ecosystems and socio-economic activities. With more than 1000 NIS introduced over the last century, the Mediterranean Sea is one of the most threatened regions worldwide, requiring an early identification of newly entered alien species for a proper environmental management. Here, we carried out environmental-DNA (eDNA) metabarcoding analyses, using multiple molecular markers (i.e., <em>18S rRNA</em>, <em>COI</em>, and <em>rbcL</em>) and different genetic databases (i.e., NCBI, PR2, SILVA, MIDORI2, MGZDB, and BOLD), on seawater and sediment samples collected on a seasonal basis in three Mediterranean ports located in the North Adriatic, Ionian and Tyrrhenian Sea to identify marine species, and particularly NIS. The use of the multi-marker eDNA metabarcoding allowed the identification of a higher number of species compared to the morphological analyses (1484 vs. 752 species), with a minor portion of species shared by both approaches. Overall, only 4 NIS were consistently identified by both morphological and molecular approaches, whereas 27 and 17 NIS were exclusively detected by using eDNA metabarcoding and classical taxonomic analyses, respectively. The eDNA metabarcoding allowed also identifying the genetic signatures of 5 NIS never reported in the Italian waters. We conclude that eDNA metabarcoding can represent a highly sensitive tool for the early identification of NIS, but a comprehensive census of the NIS requires the combination of molecular and morphological approaches.</div></div>","PeriodicalId":308,"journal":{"name":"Environment International","volume":"199 ","pages":"Article 109489"},"PeriodicalIF":10.3,"publicationDate":"2025-04-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143853860","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Urban heat island impacts on mental health in middle-aged and older adults","authors":"Yujia Bao ,&nbsp;Yongxuan Li ,&nbsp;Jiawei Gu ,&nbsp;Chen Shen ,&nbsp;Yuzheng Zhang ,&nbsp;Xiaobei Deng ,&nbsp;Lefei Han ,&nbsp;Jinjun Ran","doi":"10.1016/j.envint.2025.109470","DOIUrl":"10.1016/j.envint.2025.109470","url":null,"abstract":"<div><h3>Background</h3><div>Urban heat island (UHI), attributed to rapid urbanization, might be a latent modifiable risk factor for human health, yet little is known about whether UHI puts a strain on public mental health. This study aimed to assess the effect of the summer UHI on mental health.</div></div><div><h3>Methods</h3><div>Leveraging 338,363 urban residents from the UK Biobank, this study estimated the associations of summer UHI effect with incidence risks of mental disorders, substance use disorder, depressive disorder, and anxiety disorder using both time-independent and time-dependent Cox regression models with full adjustment for possible confounders. Furthermore, the effect of UHI on related psychiatric symptoms and brain microstructure were explored through logistic regression models and multiple linear regression models, respectively.</div></div><div><h3>Results</h3><div>In this study, summer UHI was significantly associated with the elevated risks of psychiatric disorders. The hazard ratio with a 95% confidence interval (CI) from the time-dependent Cox model was 1.04 (95% CI, 1.03–1.05) for mental disorders, 1.12 (1.11–1.14) for substance use disorder, 1.08 (1.06–1.10) for depressive disorder, and 1.06 (1.04–1.08) for anxiety disorder per standard deviation of UHI intensity, respectively. Subgroup analyses showed that females and individuals with hypertension or coronary artery disease were more vulnerable to the UHI effect on mental health. The detrimental effects on psychiatric symptoms and white matter microstructure were also observed.</div></div><div><h3>Conclusion</h3><div>The study suggested UHI could be an environmental stressor and induce a heavier burden on mental health. The effective mitigation of urban heat stress could benefit both public health and sustainable development.</div></div>","PeriodicalId":308,"journal":{"name":"Environment International","volume":"199 ","pages":"Article 109470"},"PeriodicalIF":10.3,"publicationDate":"2025-04-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143853859","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Genomic analysis of Proteus mirabilis: Unraveling global epidemiology and antimicrobial resistance dissemination − emerging challenges for public health and biosecurity","authors":"Shaqiu Zhang ,&nbsp;Qianlong Li ,&nbsp;Mingshu Wang ,&nbsp;Renyong Jia ,&nbsp;Shun Chen ,&nbsp;Mafeng Liu ,&nbsp;Dekang Zhu ,&nbsp;Xinxin Zhao ,&nbsp;Ying Wu ,&nbsp;Qiao Yang ,&nbsp;Juan Huang ,&nbsp;Xumin Ou ,&nbsp;Di Sun ,&nbsp;Bin Tian ,&nbsp;Yu He ,&nbsp;Zhen Wu ,&nbsp;Anchun Cheng","doi":"10.1016/j.envint.2025.109487","DOIUrl":"10.1016/j.envint.2025.109487","url":null,"abstract":"<div><div>Given the escalating public health threat posed by<!--> <em>Proteus mirabilis</em> <!-->(<em>P. mirabilis</em>) and its rapidly evolving drug resistance, it is imperative to elucidate its global epidemiology and resistance mechanisms through a comprehensive genomic lens. As of August 2024, 3,403 high-quality<!--> <em>P. mirabilis</em> <!-->genomes were retrieved from public databases (total 3,752), spanning 58 countries/regions, with the United States showing the highest report rate (52.51 %). Human-derived isolates, particularly from urine (34.47 %), were the primary source. A total of 239 antibiotic resistance genes (ARGs) were identified in <em>P. mirabilis</em>, with β-lactamase and carbapenemase genes being particularly widespread and isolates from China harboring the highest ARG counts. Globally,<!--> <em>P. mirabilis</em> <!-->isolates were categorized into 17 distinct clusters, with U.S. isolates showing the widest phylogenetic spread. Minimal SNP variations among isolates from different countries and hosts suggest transnational and cross-host clonal propagation. Frequent clonal transmission was also observed among diverse hosts and clinical sources.<!--> <em>P. mirabilis</em> <!-->carries numerous integrative and conjugative elements (ICEs), some facilitating ARG dissemination (n = 215). Prophages, though ubiquitous, contributed minimally to ARG spread. Spearman’s analysis revealed significant correlations between ARGs and insertion sequences (ISs), replicons, and ICEs. Ancestral state analysis indicated prophages were mainly acquired horizontally, while other mobile genetic elements (MGEs) were largely clonally transmitted. This study provides the first comprehensive genomic analysis of<!--> <em>P. mirabilis</em>’s global resistance landscape, highlighting the need to designate it as a novel antimicrobial resistance indicator and implement long-term surveillance.</div></div>","PeriodicalId":308,"journal":{"name":"Environment International","volume":"199 ","pages":"Article 109487"},"PeriodicalIF":10.3,"publicationDate":"2025-04-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143846983","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Emergence of antibiotic-resistant pathogens in ancient deep-sea sediments predates anthropogenic antibiotic use","authors":"Zhitao Wu,&nbsp;Xiaobo Zhang","doi":"10.1016/j.envint.2025.109488","DOIUrl":"10.1016/j.envint.2025.109488","url":null,"abstract":"<div><div>The rapid escalation of antibiotic resistance of pathogenic bacteria has become a critical global public health threat. Despite the extensive use of antibiotics in medicine, debates on the origins of antibiotic-resistance pathogenic bacterium remain unresolved. In this study, five antibiotic-resistant pathogenic bacteria (<em>S. epidermidis</em>, <em>S. warneri</em>, <em>A. viridans</em>, <em>B. cereus</em> or <em>S. haemolyticus</em>), which could destroy the mouse intestines, were isolated from the deep-sea sediments with the geological ages of 8,008–23,931 years, indicating that the emergence of antibiotic-resistant pathogens predated the anthropogenic antibiotic use. The deep-sea pathogenic bacteria carried multiple antibiotic-resistant genes in their genomes, which exhibited the antibiotic resistance comparable to those of the current antibiotic-resistant pathogens. During the long history of coexistence with the antibiotic-producing bacterium in the deep sea, the deep-sea pathogenic bacteria evolved the resistance to antibiotics. The antibiotic-resistant pathogenic bacteria were distributed in the deep sea, the extreme ecosystem largely unaffected by human activities. In this context, our findings contributed novel insights into the natural origin and evolution of antibiotic-resistant pathogenic bacteria, providing a foundation for developing sustainable strategies to mitigate the global health challenge of antibiotic resistance.</div></div>","PeriodicalId":308,"journal":{"name":"Environment International","volume":"199 ","pages":"Article 109488"},"PeriodicalIF":10.3,"publicationDate":"2025-04-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143846944","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Incidence and mortality of acute aflatoxicosis: A systematic review","authors":"Tess Goessens ,&nbsp;Kokeb Tesfamariam ,&nbsp;Patrick Berka Njobeh ,&nbsp;Limbikani Matumba ,&nbsp;Nyadani Jali-Meleke ,&nbsp;Yun Yun Gong ,&nbsp;Zdenko Herceg ,&nbsp;Chibundu N. Ezekiel ,&nbsp;Sarah De Saeger ,&nbsp;Carl Lachat ,&nbsp;Marthe De Boevre","doi":"10.1016/j.envint.2025.109461","DOIUrl":"10.1016/j.envint.2025.109461","url":null,"abstract":"<div><h3>Background</h3><div>Aflatoxins are mycotoxins produced by <em>Aspergillus</em> fungi in crops intended for food and feed. Acute exposure to high levels of aflatoxin B1, one of the most toxic mycotoxins, can result in severe poisoning, defined as acute aflatoxicosis, which manifests as acute hepatic failure followed by death in severe cases. Currently global burden estimates of acute aflatoxicosis are lacking – in contrast to burden estimates of chronic exposure – making it difficult to implement and prioritize risk management strategies in the prevention and control of aflatoxin exposure.</div></div><div><h3>Aim</h3><div>This systematic review assessed global evidence on the incidence and mortality of acute aflatoxicosis from 1990 to 2023. While symptomology &amp; disease duration was also examined, it served as a secondary outcome to provide additional clinical context.</div></div><div><h3>Search Strategy and Eligibility</h3><div>A structured search was conducted in PubMed, Web of Science, Embase, Scopus, INASP and grey literature. Studies were imported into Covidence for review.</div></div><div><h3>Study Selection and Extraction</h3><div>Two independent reviewers screened and extracted titles, abstracts, and full texts. Eligible studies included all human studies.</div></div><div><h3>Results</h3><div>From 11,539 references, 9 studies were included. Heterogeneity existed in study design, region, age of the study population and aflatoxin analysis. Number of cases ranged from 1 to 317, with aflatoxin concentrations varying widely, <em>i.e.</em> between 10 and 51,100 µg/kg in food, 36 and 209,000 pg/mg albumin in serum, and 19 and 18,521 pg/g in tissue. Only one outbreak provided sufficient data to estimate an attack rate of 8 cases per 100,000. Mortality ranged from 16.2 to 76.5 %, affecting children under 15 and adults over 40 most severely. Common symptoms included vomiting (77–100 %), jaundice (88–100 %), and abdominal pain (8–87 %). The risk of bias was generally low.</div></div><div><h3>Conclusion</h3><div>This review shows that acute aflatoxicosis remains a significant public health burden, especially among vulnerable groups in African countries, although the variability in studies and lack of standardized reporting make burden estimation difficult, highlighting the need for better warning systems and standardized reporting, despite challenges with infrastructure and resources in affected areas.</div></div>","PeriodicalId":308,"journal":{"name":"Environment International","volume":"199 ","pages":"Article 109461"},"PeriodicalIF":10.3,"publicationDate":"2025-04-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143845241","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Associations of prenatal glyphosate exposure with child neurodevelopment in a Canadian pregnancy cohort study","authors":"Meaghan Hall, Jillian Ashley-Martin, Christine Till, Janice Hu, Bruce Lanphear, Cynthia Curl, Tye E. Arbuckle, Michel Boivin, Linda Booij, Gina Muckle, Mandy Fisher, Elizabeth Asztalos, Maryse F. Bouchard, Amanda J. MacFarlane, Carly Hyland","doi":"10.1016/j.envint.2025.109480","DOIUrl":"https://doi.org/10.1016/j.envint.2025.109480","url":null,"abstract":"<h3>Objective</h3>Glyphosate is the most widely used pesticide worldwide. Few epidemiologic studies have examined the potential for neurotoxicity by glyphosate or its degradate, aminomethylphosphonic acid (AMPA). We examined associations of maternal urinary glyphosate and AMPA concentrations with child cognitive, social, and behavioural functioning in participants enrolled in the Maternal-Infant Research on Environmental Chemicals (MIREC) study.<h3>Methods</h3>Maternal urinary glyphosate and AMPA concentrations were measured in first trimester spot urine samples. We assessed children’s cognition (IQ) at 3–4 years of age (n = 572) using the Wechsler Preschool and Primary Scale of Intelligence-III. Social (n = 566) and behavioural (n = 840) functioning were assessed using parent-report versions of the Social Responsiveness Scale-2 and Behavioral Assessment System for Children-2. We quantified associations between maternal urinary glyphosate and AMPA concentrations and child neurodevelopmental outcomes using multivariable linear regression models and assessed effect modification by child sex, maternal folic acid, and plasma folate.<h3>Results</h3>Median (IQR) urinary glyphosate and AMPA concentrations were 0.31 (0.33) μg/L and 0.25 (0.25) μg/L. Maternal urinary glyphosate and AMPA concentrations were not significantly associated with children’s cognitive, social or behavioural functioning, and there was no evidence of effect modification. We found a non-significant inverse trend between maternal urinary AMPA concentrations and Performance IQ (B = -0.85; 95 %CI: −1.71,0.01).<h3>Conclusion</h3>In this primarily urban cohort of Canadian mother–child pairs, prenatal glyphosate and AMPA exposure were not significantly associated with child neurodevelopment. Further evaluation of glyphosate as a potential developmental neurotoxicant in a study with multiple urine samples per participant and at higher exposure levels is warranted.","PeriodicalId":308,"journal":{"name":"Environment International","volume":"9 1","pages":""},"PeriodicalIF":11.8,"publicationDate":"2025-04-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143846957","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Microplastics exposed by respiratory tract and exacerbation of community-acquired pneumonia: The potential influences of respiratory microbiota and inflammatory factors","authors":"Shaojie Liu ,&nbsp;Jianheng Zheng ,&nbsp;Wenbin Lan ,&nbsp;Zhiping Yang ,&nbsp;Meizhen Li ,&nbsp;Jing Li ,&nbsp;Jianguo Yu ,&nbsp;Shuyu Yang ,&nbsp;Jun Du ,&nbsp;Ruihua Dong ,&nbsp;Yihua Lin","doi":"10.1016/j.envint.2025.109485","DOIUrl":"10.1016/j.envint.2025.109485","url":null,"abstract":"<div><div>The relationships between microplastics (MP) exposure through respiratory and exacerbation of community-acquired pneumonia (CAP), as well as the potential influences of respiratory microbiota and inflammatory factors remain unknown in adults. Therefore, we conducted a cross-sectional study involving 50 non-severe CAP (NSCAP) and severe CAP (SCAP) patients to examine the associations of MP exposure in sputum (SP) and bronchoalveolar lavage fluid (BALF) samples with SCAP risk, and the underlying influences of respiratory microbiota and inflammatory factors. The average concentration of total MP was 23.24 μg/g dw and 4.49 μg/g dw in SP and BALF samples, with the detection rates of 98 % and 94 %. Participants who performing housework often or sedentary time ≤ 5h exhibited a higher proportion of high exposure to MP. Multivariable logistic regression and weighted quantile sum regression models showed the significantly positive relationships of single type or overall MP exposure with SCAP risk. Correlation analysis revealed that MP concentrations in BALF samples were significantly associated with multiple respiratory microbiota and inflammatory factors, particularly with the reduction in α-diversity indices of the respiratory microbiota. Our findings demonstrated that respiratory exposure to MP may cause the risk increase of SCAP, along with the alterations of respiratory microbiota and inflammatory factors. It is recommended that patients with CAP should reduce the respiratory exposure to MP for preventing the exacerbation of CAP in clinical practice.</div></div>","PeriodicalId":308,"journal":{"name":"Environment International","volume":"199 ","pages":"Article 109485"},"PeriodicalIF":10.3,"publicationDate":"2025-04-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143846975","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}