Environment International最新文献

{"title":"An assessment of organophosphate ester mixtures and the placental transcriptome","authors":"Samantha Lapehn ,&nbsp;Mariana Parenti ,&nbsp;Evan J. Firsick ,&nbsp;Dennis Khodasevich ,&nbsp;Brennan H. Baker ,&nbsp;Drew B. Day ,&nbsp;James W. MacDonald ,&nbsp;Theo K. Bammler ,&nbsp;Kurunthachalam Kannan ,&nbsp;Hyo Young Choi ,&nbsp;Emily S. Barrett ,&nbsp;Caitlin G. Howe ,&nbsp;Kecia N. Carroll ,&nbsp;Kaja Z. LeWinn ,&nbsp;Qi Zhao ,&nbsp;Andres Cardenas ,&nbsp;Adam A. Szpiro ,&nbsp;Sheela Sathyanarayana ,&nbsp;Alison G. Paquette","doi":"10.1016/j.envint.2025.109402","DOIUrl":"10.1016/j.envint.2025.109402","url":null,"abstract":"<div><div>Prenatal exposure to organophosphate ester (OPE) chemicals, commonly used as flame retardants and plasticizers, has been associated with adverse birth outcomes. The placenta is a critical fetal organ and therefore may be involved in pathogenesis of birth outcomes. The goal of this study was to evaluate associations of 10 maternal urinary OPE metabolites, individually and as a mixture, with the placental transcriptome at birth in the Conditions Affecting Neurocognitive Development and Learning in Early Childhood (CANDLE) study. Individual OPE metabolites were evaluated for associations with individual genes as well as co-expressed gene modules. Mixtures analysis was conducted using quantile g-computation. The analyses were performed with the entire data set (N = 737) as well as the sex-stratified subsets. Two genes (<em>HAP1</em> and <em>RAP1GAP</em>) were associated with bis(1,3-dichloro-2-propyl) phosphate (BDCPP), and six genes were associated the mixture in the full data set. 3 genes were associated with diphenyl phosphate (DPHP) and 36 genes were associated with the mixture in a male stratified analysis. 2 genes were associated with DPHP, and 1 gene was associated with diethyl phosphate (DEP) in a female stratified analysis. Three gene modules were associated with BDCPP or diphenyl phosphate (DPHP) and one module was associated with the OPE mixture. 12 WGCNA modules were associated with individual OPE metabolites or the mixture in males, and 1 WGCNA module was associated with DEP in females. Five of the OPE-associated gene modules were enriched for a total of 17 KEGG pathways, and 11 modules were enriched with targets of 12 nuclear hormone receptor transcription factors. Overall, novel associations were identified between the placental transcriptome and OPE metabolites, individually and in mixture, including differences based on fetal sex. These findings highlight the need for additional research on mechanisms of OPE-associated gene expression changes in the placenta and associated health outcomes.</div></div>","PeriodicalId":308,"journal":{"name":"Environment International","volume":"198 ","pages":"Article 109402"},"PeriodicalIF":10.3,"publicationDate":"2025-03-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143660600","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Unveiling the hidden impact of long-term metal-rich volcanic pollution on male reproductive functions using isotope metallomics","authors":"Lucie Sauzéat ,&nbsp;Mélanie Moreira ,&nbsp;Hélène Holota ,&nbsp;Claude Beaudoin ,&nbsp;David H. Volle","doi":"10.1016/j.envint.2025.109388","DOIUrl":"10.1016/j.envint.2025.109388","url":null,"abstract":"<div><div>Volcanic eruptions release particles in a range of sizes that can chronically affect the health of communities within tens of kilometers of the volcano. Many years after an eruption, resuspension of volcanic ash can exacerbate the health impact of primary eruptive events. So far, our global understanding of the health effects triggered by chronic exposure to volcanic particles at the whole-body scale is limited. Recently, it has been shown that mice chronically exposed to metal-rich volcanic ash deposits present metallome deregulations associated with pathophysiological changes. These deregulations preferentially impact the reproductive functions, questioning about the impact of ash on fertility. This work aims to further assess the mechanisms driving the ash-related fertility disorders and develop predictive biomarkers. For that, elemental concentrations and Cu-Zn-Fe isotope measurements coupled to metabolomic, proteomic and transcriptomic analyses were measured in blood, liver and two organs of the male reproductive system (testis, seminal vesicle). The samples were collected on wild-type and mice exposed over two months to volcanic ash. Mice exposed to ash are characterized by (i) significant metallomic deregulations, (ii) higher oxidative stress correlating with isotopic variations of redox-sensitive elements and (iii) testicular and hepatic alterations, marked by gains in organ mass, hepatic lipid accumulation and circulating bile acids overload, all of which might exacerbate testicular defects. Together, these results demonstrate that prolonged exposure to metal-rich ash is a threat for male reproduction and that investigating redox-sensitive isotopes might help identifying early signs of oxidative stress-related testicular injuries, with future implications for hepato-testicular disease prevention.</div></div>","PeriodicalId":308,"journal":{"name":"Environment International","volume":"198 ","pages":"Article 109388"},"PeriodicalIF":10.3,"publicationDate":"2025-03-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143660638","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Examining the social distributions in neighbourhood black carbon and ultrafine particles in Montreal and Toronto, Canada","authors":"Emmanuelle Batisse ,&nbsp;Marshall Lloyd ,&nbsp;Alicia Cavanaugh ,&nbsp;Arman Ganji ,&nbsp;Junshi Xu ,&nbsp;Marianne Hatzopoulou ,&nbsp;Jill Baumgartner ,&nbsp;Scott Weichenthal","doi":"10.1016/j.envint.2025.109395","DOIUrl":"10.1016/j.envint.2025.109395","url":null,"abstract":"<div><h3>Background</h3><div>Socioeconomic inequities in outdoor ultrafine particles (UFP) and black carbon (BC) are understudied in Canada, where metropoles like Montreal and Toronto feature distinct sociodemographic diversity and urban characteristics compared to U.S. cities.</div></div><div><h3>Methods</h3><div>We collected vulnerability indicators, including social, economic, household composition, and immigration status, at the dissemination area level for Montreal and Toronto using data from the 2006 and 2021 Canadian Census of Population. Areas were classified as disadvantaged, intermediate, or advantaged following K-means clustering analysis. We aggregated and calculated population-weighted average concentrations of BC and UFP, and UFP size at the dissemination area and cluster levels using high-resolution exposure surfaces, derived from year-long mobile monitoring campaigns conducted in each city during 2020–2021. Final exposure surfaces were generated by integrating predictions from land-use regression models and deep convolutional neural network models.</div></div><div><h3>Findings</h3><div>We observed high within-city variations in aggregated air pollutant levels, with higher outdoor BC and UFP concentrations and smaller UFP sizes in areas near local sources such as major roads, railways, airports, and densely populated regions. Advantaged areas experienced the lowest median UFP concentrations in both Montreal (10,707 pt/cm³) and Toronto (10,988 pt/cm³), as well as the lowest BC concentrations (650 ng/m³) in Montreal. The highest median UFP concentrations were observed in intermediate areas in Montreal (15,709 pt/cm³) and disadvantaged areas in Toronto (12,228 pt/cm³). Conversely, the highest BC concentrations were observed in disadvantaged and intermediate areas in Montreal (805–811 ng/m³), and disadvantaged and advantaged areas in Toronto (1,228–1,252 ng/m³). Notably, high priority areas for the double burden of vulnerability and high BC and UFP concentrations were located near air pollutants local emission sources.</div></div><div><h3>Interpretation</h3><div>Our findings highlight the importance of prioritizing exposure mitigation for populations residing near local sources and to understand contextual factors influencing inequities across cities and pollutants.</div></div>","PeriodicalId":308,"journal":{"name":"Environment International","volume":"198 ","pages":"Article 109395"},"PeriodicalIF":10.3,"publicationDate":"2025-03-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143654158","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Bioaccumulation and sources of typical emerging pollutants via farming activities: Insight from risk assessment and mitigation","authors":"Qiongping Sun ,&nbsp;Jingru Zhang ,&nbsp;Zhixin Zheng ,&nbsp;Qianqian Yu ,&nbsp;Ting Wei ,&nbsp;Jieyi Diao ,&nbsp;Xuan Yu ,&nbsp;Lulu Zhang ,&nbsp;Qiusen Huang ,&nbsp;Tieyu Wang","doi":"10.1016/j.envint.2025.109399","DOIUrl":"10.1016/j.envint.2025.109399","url":null,"abstract":"<div><div>Emerging contaminants are increasingly and ubiquitously found in both aquatic and terrestrial farms. However, their sources poorly understood, which results in limited capacity to manage and control the ecological and human health risks. The targeted pollutants such as hormones, antibiotics, and phenols were analyzed in farming water, surrounding rivers, feed, biota and feces in the present study. In farming water, the phenols were more prevalent contaminants in aquatic farms, whereas antibiotics were predominant in terrestrial farms, which was partially attributable to the distribution of targeted pollutants in used feed. Notably, the sewage treatment system of terrestrial farms effectively reduced hormones (removal rate: 98.38%) and antibiotics (removal rate: 91.98%), but showed poorly in removing phenols, with their concentrations actually increasing by 37%. This raised significant concerns, as phenols from treated wastewater into rivers posed a threat to aquatic organisms such as fish and daphnia. Moreover, daily pollutant exposure was higher for females than for males, with the highest exposure resulting from the consumption of <em>Penaeus vannamei</em>. The higher exposure to emerging contaminants among females aged 18–29, the critical reproductive phase, warrants special attention due to the potential risks to both their maternal health and fetal development. Overall, this study can propose guidance for all stakeholders to control emerging pollutant emissions from farming and ensure food safety, which is the crucial element for managing the ecological environment and preventing risks.</div></div>","PeriodicalId":308,"journal":{"name":"Environment International","volume":"198 ","pages":"Article 109399"},"PeriodicalIF":10.3,"publicationDate":"2025-03-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143654157","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Development of a multi-module data-driven integrated framework for identifying drivers of atmospheric particulate nitrate and reduction emissions: An application in an industrial city, China","authors":"Jiaqi Dong ,&nbsp;Yulong Yan ,&nbsp;Lin Peng ,&nbsp;Xingcheng Lu ,&nbsp;Ke Yue ,&nbsp;Yueyuan Niu ,&nbsp;Junjie Li ,&nbsp;Yunfei Ge ,&nbsp;Kai Xie ,&nbsp;Xiaolin Duan","doi":"10.1016/j.envint.2025.109394","DOIUrl":"10.1016/j.envint.2025.109394","url":null,"abstract":"<div><div>Atmospheric particulate nitrate (pNO₃^-), a crucial component of fine particulate matter, significantly contributes to haze pollution. The formation of pNO₃^- is driven by multiple factors including meteorology, emissions, and atmospheric chemistry. Understanding the key drivers of pNO₃^- formation and developing an accurate and physically meaningful method for the timely assessment of the direct causes of pNO₃^- pollution are essential. In this study, we propose a multi-module data-driven integrated framework that incorporates and improves four distinct machine learning modules. This framework enhances the physical interpretability of the statistical outcomes of the driving factors of pNO₃^-, quantifies the impacts of multiple factors on pNO₃^-, and reveals emission reduction trends. Our findings show that meteorology and emissions affect pNO₃^- by 35.3 % and 64.7 %, respectively, while atmospheric chemistry (48.0 %) and humidity (17.1 %) are the key drivers of its formation. Photochemistry promotes the formation of pNO₃^- in summer, whereas liquid-phase reactions dominate in winter at higher humidity levels (&gt;60 %). The industry source (IS) (14.3 %), combustion source (CS) (12.8 %), and transportation source (TS) (11.8 %) are the main emission sources. The formation of pNO₃^- by the primary emissions and the transformation of NOx emitted from CS and TS is more sensitive to the changes of meteorological conditions, and controlling CS has the greater benefits to reduce pNO₃^-. The proposed framework could provide a reliable method for identifying drivers of pNO₃^- pollution at different haze events, supporting the formulation of control measures.</div></div>","PeriodicalId":308,"journal":{"name":"Environment International","volume":"198 ","pages":"Article 109394"},"PeriodicalIF":10.3,"publicationDate":"2025-03-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143654159","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Long term exposure to multiple environmental stressors induces mitochondrial dynamics imbalance in testis: Insights from metabolomics and transcriptomics","authors":"Shiqin Jiang ,&nbsp;Tianli Nong ,&nbsp;Ting Yu ,&nbsp;Zhiyan Qin ,&nbsp;Junyuan Huang ,&nbsp;Zhaokun Yin ,&nbsp;Shiqi Luo ,&nbsp;Yating Lai ,&nbsp;Jing Jin","doi":"10.1016/j.envint.2025.109390","DOIUrl":"10.1016/j.envint.2025.109390","url":null,"abstract":"<div><div>Long-term exposure to adverse environment stressors (e.g. noise pollution, temperature, and crowding) impaired human health. However, research on the toxic effects of adverse environmental stressors on the male reproductive system is limited. This study employed integrated phenomics, metabolomics, and transcriptomics to investigate physiological disturbances in the testis of mice exposed to multiple adverse environmental stressors for two months. Phenotypic studies indicated that long-term environmental stimuli resulted in significant damage to the blood-testis barrier (BTB) and testes, evidenced by reduced testicular index, disrupted testicular tissue structure, abnormal tight junction protein expression, and spermatozoa abnormalities. Comprehensive multi-omics analysis revealed that long-term exposure to environmental stressors disrupted the BTB and testes, which was associated with mitochondrial metabolism disorders, including oxidative phosphorylation and fatty acid beta-oxidation, as well as glutathione and lipid metabolism alterations. Among these dysregulated pathways, significant alterations were observed in the critical regulators of mitochondrial fusion (MFN2) and fission (DRP1) within the BTB. Specifically, corticosterone treatment decreased tight junction protein expression, increased reactive oxygen species (ROS) levels, and impaired mitochondrial morphology and function, as evidenced by reduced mitochondrial membrane potential, elevated calcium ion concentration, and shortened mitochondrial length and network <em>in vitro</em>. Moreover, inhibiting DRP1 with Mdivi-1 or overexpressing MFN2 mitigated the corticosterone-induced reduction of tight junctions and mitochondrial dysregulation in TM4 cells. Collectively, maintaining mitochondrial homeostasis emerges as a promising strategy to alleviate the BTB and testicular injury induced by long-term exposure to multiple environmental stressors.</div></div>","PeriodicalId":308,"journal":{"name":"Environment International","volume":"198 ","pages":"Article 109390"},"PeriodicalIF":10.3,"publicationDate":"2025-03-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143640261","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Artificial intelligence: A key fulcrum for addressing complex environmental health issues","authors":"Lei Huang ,&nbsp;Qiannan Duan ,&nbsp;Yuxin Liu ,&nbsp;Yangyang Wu ,&nbsp;Zenghui Li ,&nbsp;Zhao Guo ,&nbsp;Mingliang Liu ,&nbsp;Xiaowei Lu ,&nbsp;Peng Wang ,&nbsp;Fan Liu ,&nbsp;Futian Ren ,&nbsp;Chen Li ,&nbsp;Jiaming Wang ,&nbsp;Yujia Huang ,&nbsp;Beizhan Yan ,&nbsp;Marianthi-Anna Kioumourtzoglou ,&nbsp;Patrick L. Kinney","doi":"10.1016/j.envint.2025.109389","DOIUrl":"10.1016/j.envint.2025.109389","url":null,"abstract":"<div><div>Environmental health (EH) is a complex and interdisciplinary field dedicated to the examination of environmental behaviours, toxicological effects, health risks, and strategies for mitigating harmful environmental factors. Traditional EH research investigates correlations between risk factors and health outcomes through control variables, but this route is difficult to address complex EH issue. Artificial intelligence (AI) technology not only has accelerated the innovation of the scientific research paradigm but also has become an important tool for solving complex EH problems. However, the in-depth and comprehensive implementation of AI in the field of EH still faces many barriers, such as model generalizability, data privacy protection, algorithm transparency, and regulatory and ethical issues. This review focuses on the compound exposures of EH and explores the potential, challenges, and development directions of AI in four key phases of EH research: (1) data collection, fusion, and management, (2) hazard identification and screening, (3) risk modeling and assessment and (4) EH management. It is not difficult to see that in the future, artificial intelligence technology will inevitably carry out multidimensional simulation of complex exposure factors through multi-mode data fusion, so as to achieve accurate identification of environmental health risks, and eventually become an efficient tool for global environmental health management. This review will help researchers re-examine this strategy and provide a reference for AI to solve complex exposure problems.</div></div>","PeriodicalId":308,"journal":{"name":"Environment International","volume":"198 ","pages":"Article 109389"},"PeriodicalIF":10.3,"publicationDate":"2025-03-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143640259","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Persistent effects of early-life exposure to dibutyl phthalate on zebrafish: Immune system dysfunction via HPA axis","authors":"Yue Tao ,&nbsp;Yanyan Gu ,&nbsp;Haorui Wang ,&nbsp;Guanyu Zhong ,&nbsp;Aoxue Wang ,&nbsp;Jianhua Qu ,&nbsp;Jiayi Feng ,&nbsp;Ying Zhang","doi":"10.1016/j.envint.2025.109386","DOIUrl":"10.1016/j.envint.2025.109386","url":null,"abstract":"<div><div>The plasticizer dibutyl phthalate (DBP) is one of the common contaminants in the aquatic environment and has been verified to be detrimental to aquatic organisms. In this research, zebrafish was employed to explore the toxic mechanism of DBP at environmental concentrations. The findings indicated that DBP led to abnormal development of zebrafish larvae, encompassing an increase in heart rate and malformation rate, as well as a reduction in survival rate and hatching rate. DBP also induced HPA axis activation, increased glucocorticoid content and microglia activation in zebrafish larvae. Moreover, adult zebrafish in the early-life exposure and long-term exposure groups demonstrated anxiety-like and depression-like behaviors. RNA-seq analysis revealed that early embryonic exposure to DBP led to persistent damage in zebrafish that could not be recovered in adulthood. The HPA axis was more severely disorganized in males than in females, and sex-specific differences were also shown in immunotoxicity. It is speculated that the immune system disorder could partially attribute to the out-of-control HPA axis, while the activation of inflammatory cells and inflammatory factors will further exacerbate the situation of HPA axis dysregulation.</div></div>","PeriodicalId":308,"journal":{"name":"Environment International","volume":"198 ","pages":"Article 109386"},"PeriodicalIF":10.3,"publicationDate":"2025-03-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143635595","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Serum biomonitoring of per- and polyfluoroalkyl substances (PFASs) in the adult population of Switzerland: Results from the pilot phase of the Swiss health study","authors":"Alexandra Jaus ,&nbsp;Céline Fragnière Rime ,&nbsp;Julien Riou ,&nbsp;Beat J. Brüschweiler ,&nbsp;Murielle Bochud ,&nbsp;Natalie von Goetz","doi":"10.1016/j.envint.2025.109382","DOIUrl":"10.1016/j.envint.2025.109382","url":null,"abstract":"<div><div>Monitoring human exposure to per- and polyfluoroalkyl substances (PFASs) is of significant public health relevance, given the documented associations between PFAS exposure and a range of adverse health outcomes. This study aimed to provide a sensitive and reliable analytical approach for the determination of PFASs in human serum and to advance the understanding of PFAS exposure.</div><div>Serum samples from 630 adult participants from the population-based Swiss Health Study pilot phase were analysed for 30 legacy and emerging PFASs. Quantitative analysis was performed after specific sample preparation using high-performance liquid chromatography coupled to mass spectrometry. The association between PFAS serum concentrations and selected demographic and behavioural parameters of interest was assessed using linear regression.</div><div>The developed method enabled sensitive high-throughput analysis and resulted in reliable validation parameters and robust quantification performance. The study revealed that, while the prevalence of emerging PFASs was observed to be marginal, legacy PFASs predominated. Perfluorooctane sulfonic acid (PFOS, geometric mean (GM) 6.6 ng/mL), perfluorooctanoic acid (PFOA, GM 1.3 ng/mL) and perfluorohexane sulfonic acid (PFHxS, GM 1.2 ng/mL) were detected in all serum samples and contributed 88 % to the median sum of determined PFASs (10.3 ng/mL). The levels of PFOA and PFOS were found to be associated with age and gender. Furthermore, PFOS levels were associated with consumption of fish, particularly freshwater species, while PFOA levels were negatively associated with the duration of breastfeeding. Regional disparities were also observed. Several results exceeded specific health thresholds for PFAS intake or human biomonitoring, but the observed values were overall comparable to similar studies conducted worldwide.</div><div>The provision of comprehensive information on a wide range of legacy and emerging PFASs facilitates a more complete identification of possible sources of exposure, not only in the regions concerned, but also beyond, and establishes a robust foundation for the guidance of future investigations.</div></div>","PeriodicalId":308,"journal":{"name":"Environment International","volume":"198 ","pages":"Article 109382"},"PeriodicalIF":10.3,"publicationDate":"2025-03-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143635594","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Associations between long-term air pollution exposure and mortality and cardiovascular morbidity: A comparison of mobility-integrated and residential-only exposure assessment","authors":"Aisha Ndiaye ,&nbsp;Danielle Vienneau ,&nbsp;Benjamin Flückiger ,&nbsp;Nicole Probst-Hensch ,&nbsp;Ayoung Jeong ,&nbsp;Medea Imboden ,&nbsp;Oliver Schmitz ,&nbsp;Meng Lu ,&nbsp;Roel Vermeulen ,&nbsp;Kalliopi Kyriakou ,&nbsp;Youchen Shen ,&nbsp;Derek Karssenberg ,&nbsp;Kees de Hoogh ,&nbsp;Gerard Hoek","doi":"10.1016/j.envint.2025.109387","DOIUrl":"10.1016/j.envint.2025.109387","url":null,"abstract":"<div><div>Epidemiological studies investigating the health effects of long-term air pollution exposure typically only consider the participants’ residential addresses when determining exposure. Neglecting mobility may introduce measurement error, potentially leading to bias or reduced precision of exposure-health relationships in epidemiological studies. In this study we compared the exposure-health associations between residential-only and mobility-integrated air pollution exposures.</div><div>We evaluated two major pollutants, NO₂ and PM_2.5, and four health outcomes, natural and cause-specific mortality and coronary and cerebrovascular events. Agent-based modeling (ABM) was used to simulate the mobility patterns of the participants in the EPIC-NL cohort in the Netherlands and the Swiss National Cohort (SNC) in Switzerland, based on travel survey information. To obtain mobility-integrated exposures, hourly air pollution surfaces were developed and overlaid with the time-dependent location data from the ABM. We used Cox proportional hazards models within each cohort separately to evaluate the association between residential-only and mobility-integrated exposure and mortality and cardiovascular events, adjusting for major individual and area-level covariates.</div><div>The mobility-integrated exposure and the residential exposure showed very high correlations for both pollutants and cohorts (R² &gt; 0.97). The mean exposure was 1–2 % and the exposure contrast 10–20 % lower for the mobility-integrated exposure. For all health outcomes, both pollutants and both cohorts, there were only small differences between residential-only and mobility-integrated exposure effect estimates. For the SNC, Hazard ratios (HRs) for natural mortality were 1.04 (1.03 – 1.04) and 1.03 (1.03 – 1.04) per interquartile range (IQR) increase in NO₂ for residential and mobility-integrated exposure, respectively. For PM_2.5 the corresponding estimates were 1.01 (1.01 – 1.02) per IQR increase for both approaches. Our findings support the growing evidence that assessment of long-term air pollution exposure at the residential address only in epidemiological studies may not lead to substantial bias and loss of precision in health effects estimates.</div></div>","PeriodicalId":308,"journal":{"name":"Environment International","volume":"198 ","pages":"Article 109387"},"PeriodicalIF":10.3,"publicationDate":"2025-03-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143635592","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}