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Rap1 and mTOR signaling pathways drive opposing immunotoxic effects of structurally similar aryl-OPFRs, TPHP and TOCP Rap1和mTOR信号通路驱动结构相似的芳基-OPFR(TPHP和TOCP)产生截然相反的免疫毒性效应
IF 11.8 1区 环境科学与生态学
Environment International Pub Date : 2024-12-16 DOI: 10.1016/j.envint.2024.109215
Bilin Zhao, Shuang Zheng, Gaoxiang Yang, Zhijun He, Jiewei Deng, Lijuan Luo, Xinyan Li, Tiangang Luan
{"title":"Rap1 and mTOR signaling pathways drive opposing immunotoxic effects of structurally similar aryl-OPFRs, TPHP and TOCP","authors":"Bilin Zhao, Shuang Zheng, Gaoxiang Yang, Zhijun He, Jiewei Deng, Lijuan Luo, Xinyan Li, Tiangang Luan","doi":"10.1016/j.envint.2024.109215","DOIUrl":"https://doi.org/10.1016/j.envint.2024.109215","url":null,"abstract":"Aryl organophosphorus flame retardants (aryl-OPFRs), commonly used product additives with close ties to daily life, have been regrettably characterized by multiple well-defined toxicity risks. Triphenyl phosphate (TPHP) and tri-o-cresyl phosphate (TOCP), two structurally similar aryl-OPFRs, were observed in our previous study to exhibit contrasting immunotoxic effects on THP-1 macrophages, yet the underlying mechanisms remain unclear. This study sought to address the knowledge gap by integrating transcriptomic and metabolomic analyses to elucidate the intricate mechanisms. During individual omics analyses, we unfortunately only obtained highly similar results for both TPHP and TOCP, failing to identify the key reasons for their differences. These results revealed comparable disturbances induced by both compounds, including disruptions in nucleic acid synthesis and energy metabolism, blocking ADP to ATP conversion by reducing TCA cycle intermediates, consequently leading to ATP depletion. However, through integrative analysis, specific pathways affected by each compound were successfully identified, shedding light on their unique effects. TPHP reduced GTP levels necessary for Rap1 activation, thereby inhibiting phagocytosis and adhesion of THP-1 macrophages. Conversely, TOCP stimulated the mTOR signaling pathway, enhancing phosphorylation of downstream proteins S6K, RHOA, and PKC, consequently promoting immune responses. This study not only clarified the distinct immunotoxic mechanisms of TPHP and TOCP but also provided critical insights into how structural variations in aryl-OPFRs can lead to markedly different immune responses, thereby informing future risk assessments and regulatory strategies for these compounds.","PeriodicalId":308,"journal":{"name":"Environment International","volume":"20 1","pages":""},"PeriodicalIF":11.8,"publicationDate":"2024-12-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142832646","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
An extended PFAS profiling of a Swedish subpopulation and mixture risk assessments using multiple approaches 采用多种方法对瑞典的一个亚群进行全氟辛烷磺酸扩展分析和混合物风险评估
IF 11.8 1区 环境科学与生态学
Environment International Pub Date : 2024-12-16 DOI: 10.1016/j.envint.2024.109214
Josefin A. Engelhardt, Merle M. Plassmann, Jana M. Weiss
{"title":"An extended PFAS profiling of a Swedish subpopulation and mixture risk assessments using multiple approaches","authors":"Josefin A. Engelhardt, Merle M. Plassmann, Jana M. Weiss","doi":"10.1016/j.envint.2024.109214","DOIUrl":"https://doi.org/10.1016/j.envint.2024.109214","url":null,"abstract":"Per- and polyfluoroalkyl substances (PFAS) have been detected worldwide, from the deep seas to polar regions. A previous review showed that PFAS are risk drivers of the chemical mixture present in human blood. This study focused on establishing the PFAS exposure of a Swedish subpopulation and investigated whether the exposure poses a risk of adverse health effects. Human serum from 60 blood donors in Stockholm, Sweden, was analyzed. A target method including 32 PFAS analytes and over 270 suspect features was used to detect and quantify PFAS. Twenty-six PFAS were quantified, and 7 suspect PFAS features (6H-PFCAs and PFECHS) were semi-quantified. Nine mixture risk assessment (MRA) strategies were used to assess the risk of health outcomes. Fifteen effect levels were derived and used, along with 15 already established values. The certainty of various derivation techniques was discussed. The MRAs showed that the entire studied population exceeded some of the risk thresholds, with effects including high cholesterol and immune suppression. However, the certainty was lower when deriving these two effect levels. The MRA, using human biomonitoring guidance values (high certainty), concluded that for 63 % of the individuals, a risk for adverse health effects cannot be excluded. This study has demonstrated that there is a reason for concern regarding PFAS exposure in the general population of Sweden. To our knowledge, this is the first time the H-PFCAs have been semi-quantified in human blood using a reference standard.","PeriodicalId":308,"journal":{"name":"Environment International","volume":"38 1","pages":""},"PeriodicalIF":11.8,"publicationDate":"2024-12-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142832647","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Effects of diesel exhaust inhalation on cognitive performance in human volunteers: A randomized controlled crossover study
IF 11.8 1区 环境科学与生态学
Environment International Pub Date : 2024-12-15 DOI: 10.1016/j.envint.2024.109213
Jason Curran, A.J. Hirsch Allen, Christopher F. Rider, Robin Shutt, Chris Carlsten
{"title":"Effects of diesel exhaust inhalation on cognitive performance in human volunteers: A randomized controlled crossover study","authors":"Jason Curran, A.J. Hirsch Allen, Christopher F. Rider, Robin Shutt, Chris Carlsten","doi":"10.1016/j.envint.2024.109213","DOIUrl":"https://doi.org/10.1016/j.envint.2024.109213","url":null,"abstract":"<h3>Background</h3>Mounting evidence links exposure to traffic-related air pollution (TRAP) to impairment in cognitive functioning.<h3>Objectives</h3>To determine if short-term, controlled exposure to diesel exhaust (DE) adversely affects one or more cognitive function domains.<h3>Methods</h3>We carried out a double-blinded crossover design with 28 healthy, adult volunteers. Volunteers were exposed to two conditions for 120 min each, on separate order-randomized occasions: filtered air (FA) and DE (300 µg/m<sup>3</sup> PM<sub>2.5</sub>) at the Air Pollution Exposure Laboratory (APEL) at Vancouver General Hospital (VGH). Volunteers were blinded to the two exposure conditions. Volunteers completed five computerised neuropsychological tests of the Cambridge Neuropsychological Test Automated Battery (CANTAB) prior to (2-hr before) and at three timepoints following each exposure condition (0-hr, 3-h post-, and 24-h post-exposure). The selected CANTAB tests were related to five cognitive domains – attention, spatial working memory, strategy use, executive function, and processing speed. We hypothesized that short-term diesel exposure would adversely affect one or more cognitive function domains.<h3>Results</h3>Following screening, 15 volunteers were randomized to receive FA followed by DE and 14 volunteers were randomized to receive the exposures in the reverse sequence. A total of 28 volunteers contributed to the final analysis. Short-term exposure to DE was associated with slower reaction times in the Reaction Time Index task. DE was associated with a decrease of 18.2 ms (p = 0.05) in simple reaction time and 23.5 ms (p = 0.04) in five-choice reaction time.<h3>Conclusions</h3>This first study to investigate the effects of TRAP on the cognitive performance of humans in a controlled environment shows slowed reaction times similar to those previously demonstrated with blood alcohol levels of 0.05%. Important implications exist for workers in occupations where attention and reaction time are connected to safety and performance.","PeriodicalId":308,"journal":{"name":"Environment International","volume":"28 1","pages":""},"PeriodicalIF":11.8,"publicationDate":"2024-12-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142823220","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Improving WRF-Chem PM2.5 predictions by combining data assimilation and deep-learning-based bias correction 通过结合数据同化和基于深度学习的偏差校正改进 WRF-Chem PM2.5 预测
IF 11.8 1区 环境科学与生态学
Environment International Pub Date : 2024-12-15 DOI: 10.1016/j.envint.2024.109199
Xingxing Ma, Hongnian Liu, Zhen Peng
{"title":"Improving WRF-Chem PM2.5 predictions by combining data assimilation and deep-learning-based bias correction","authors":"Xingxing Ma, Hongnian Liu, Zhen Peng","doi":"10.1016/j.envint.2024.109199","DOIUrl":"https://doi.org/10.1016/j.envint.2024.109199","url":null,"abstract":"In numerical model simulations, data assimilation (DA) on the initial conditions and bias correction (BC) of model outputs have been proven to be promising approaches to improving PM<sub>2.5</sub> (particulate matter with an aerodynamic equivalent diameter of ≤ 2.5 μm) predictions. This study compared the optimization effects of these two methods and developed a new scheme that combines DA and BC simultaneously. Four parallel experiments were conducted during winter 2019: a control experiment directly forecasted by WRF-Chem (experiment name: WRF-Chem); an experiment that assimilated <em>in situ</em> observations based on the GSI (Gridpoint Statistical Interpolation) system (WRF-Chem_DA); an experiment with deep-learning-based BC (WRF-Chem_BC); and an experiment considering the combination of DA on the initial conditions and BC (WRF-Chem_DA_BC). Statistically, the accuracy of PM<sub>2.5</sub> predictions could be optimized by both DA and BC for the first 24-h period, and WRF-Chem_BC performed better than WRF-Chem_DA in the initial field, especially in the period of 10–24 h, while the best performance was achieved by combining BC and DA. Throughout the initial 24-h period, compared with the control experiment, the results of WRF-Chem_DA_BC (WRF-Chem_DA, WRF-Chem_BC) showed an improvement in terms of root-mean-square error, with reduction proportions varying from 38.90 % to 48.86 % (18.88 % to 32.44 %, 30.10 % to 46.08 %). Besides having the best optimization effect over the whole domain, the combined method also performed well in different regions: during the forecasting period of 0–24 h, the RMSEs decreased from 32 % to 62 %, 39 % to 57 %, 28 % to 40 %, and 30 % to 49 % in the Beijing–Tianjin–Hebei, Yangtze River Delta, Central China, and Sichuan Basin urban agglomerations, respectively.","PeriodicalId":308,"journal":{"name":"Environment International","volume":"33 1","pages":""},"PeriodicalIF":11.8,"publicationDate":"2024-12-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142823253","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Associations of early life perfluoroalkyl and polyfluoroalkyl substances (PFAS) exposure with body mass index and risk of overweight or obesity at age 2–18 years: Mixture analysis in the prospective Boston Birth Cohort
IF 11.8 1区 环境科学与生态学
Environment International Pub Date : 2024-12-15 DOI: 10.1016/j.envint.2024.109206
Zeyu Li, Guoying Wang, Joseph M. Braun, Xiumei Hong, Giehae Choi, Shawn P. O’Leary, Chang Ho Yu, Colleen Pearson, William G. Adams, Zhihua (Tina) Fan, Jessie P. Buckley, Xiaobin Wang
{"title":"Associations of early life perfluoroalkyl and polyfluoroalkyl substances (PFAS) exposure with body mass index and risk of overweight or obesity at age 2–18 years: Mixture analysis in the prospective Boston Birth Cohort","authors":"Zeyu Li, Guoying Wang, Joseph M. Braun, Xiumei Hong, Giehae Choi, Shawn P. O’Leary, Chang Ho Yu, Colleen Pearson, William G. Adams, Zhihua (Tina) Fan, Jessie P. Buckley, Xiaobin Wang","doi":"10.1016/j.envint.2024.109206","DOIUrl":"https://doi.org/10.1016/j.envint.2024.109206","url":null,"abstract":"<h3>Background</h3>Perfluoroalkyl and polyfluoroalkyl substances (PFAS) are a class of widespread persistent chemicals, which may have obesogenic effects during the fetal period. This study investigated the long-term association of maternal plasma PFAS concentrations at delivery and their mixture with child body mass index (BMI) and the risk of Overweight or Obesity (OWO) at the age of 2–18 years.<h3>Methods</h3>The study included 1189 mother–child dyads from the prospective Boston Birth Cohort. Eight PFAS were measured in maternal plasma samples collected 24–72 h after delivery. Outcomes were BMI Z-score and OWO status of children at 2–18 years. The exposure-outcome associations were evaluated with linear mixed-effects regression for individual PFAS and Bayesian kernel machine regression (BKMR) and quantile-based g-computation models for PFAS mixture. We explored the effect modification by maternal pre-pregnancy OWO, child age, sex, and race.<h3>Results</h3>Maternal plasma samples had PFAS detection frequencies from 87 % to 100 % and geometric means ranging from 0.11 to 3.67 ng/mL. PFHpS and PFHxS were associated with higher child BMI Z-score. Such associations were stronger in children aged 6–12 years and 13–18 years than in 2–5 years. Stratified by maternal pre-pregnancy OWO, significant associations of the PFAS mixture and child BMI Z-score were only found in children with non-OWO mothers. In children aged 13–18 years, children with both high maternal plasma PFDeA, PFNA, and PFOA concentrations and maternal OWO had the highest risks of OWO compared to children only with either. Such synergetic effects were not found in younger children.<h3>Conclusions</h3>Early life exposure to individual PFAS and their mixture were associated with a higher risk of childhood OWO, with stronger associations observed in older child age groups and in children of non-OWO mothers. Synergetic effects of PFAS exposures and maternal pre-pregnancy OWO became evident in adolescence.","PeriodicalId":308,"journal":{"name":"Environment International","volume":"29 1","pages":""},"PeriodicalIF":11.8,"publicationDate":"2024-12-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142823219","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The direct and urinary electrolyte-mediated effects of ambient temperature on population blood pressure: A causal mediation analysis
IF 11.8 1区 环境科学与生态学
Environment International Pub Date : 2024-12-13 DOI: 10.1016/j.envint.2024.109208
Ayesha Mukhopadhyay, Momenul Haque Mondol, Mahbubur Rahman, Leanne Unicomb, Rizwana Khan, Hoimonty Mazumder, Mohammad Nahian Ferdous, Emily V. Pickering, Konstantinos C. Makris, Alberto J. Caban-Martinez, Faruk Ahmed, Mohammad Shamsudduha, Fawaz Mzayek, Chunrong Jia, Hongmei Zhang, Anwar Musah, Lora E. Fleming, Mathew P. Smeltzer, Howard H. Chang, John L. Jefferies, Abu Mohd Naser
{"title":"The direct and urinary electrolyte-mediated effects of ambient temperature on population blood pressure: A causal mediation analysis","authors":"Ayesha Mukhopadhyay, Momenul Haque Mondol, Mahbubur Rahman, Leanne Unicomb, Rizwana Khan, Hoimonty Mazumder, Mohammad Nahian Ferdous, Emily V. Pickering, Konstantinos C. Makris, Alberto J. Caban-Martinez, Faruk Ahmed, Mohammad Shamsudduha, Fawaz Mzayek, Chunrong Jia, Hongmei Zhang, Anwar Musah, Lora E. Fleming, Mathew P. Smeltzer, Howard H. Chang, John L. Jefferies, Abu Mohd Naser","doi":"10.1016/j.envint.2024.109208","DOIUrl":"https://doi.org/10.1016/j.envint.2024.109208","url":null,"abstract":"High ambient heat can directly influence blood pressure (BP) through the vasodilation of the skin vasculature and indirectly by affecting urinary volume and electrolyte levels. We evaluated the direct and urine electrolyte-mediated effects of ambient temperature on BP. We pooled 5,624 person-visit data from a community-based stepped-wedge randomized control trial in southwest coastal Bangladesh from December 2016 to May 2017. Same-day ambient temperature data from local weather stations were linked to participant BP and urine electrolytes using geo-locations of their residential addresses. We implemented causal mediation analyses using the product methods of coefficients with linear mixed models under the sequential ignorability assumption. Separate models were run for each urinary electrolyte mediator (sodium, potassium, calcium, and magnesium) followed by combined models to evaluate the natural direct and electrolyte-mediated indirect effects of temperature on BP. Models had participant-level random intercepts and were adjusted for age, sex, body mass index (BMI), religion, exercise, smoking status, sleep hours, alcohol consumption, urine creatinine, time trend, household assets, drinking water salinity, and seasonality. For the combined mediators (sodium, potassium, calcium, and magnesium), for every 5°C increase in average daily temperature: the direct effect on systolic BP was −1.42 (95 % CI: −1.94, −0.92) mmHg and urine sodium mediated effect was −0.12 (95 % CI: −0.20, −0.05) mmHg; while urine potassium mediated effect was 0.15 (95 % CI: 0.08, 0.25) mmHg; urine calcium-mediated effect 0.06 (95 % CI: 0.01, 0.12) mmHg; and urine magnesium mediated effect −0.00 (95 % CI: −0.03, 0.02) mmHg. We detected similar associations for diastolic BP, pulse pressure, and mean arterial pressure. We found a significant inverse direct effect of ambient temperature on BP compared to minimally mediated urine electrolyte effects. Further studies are needed to uncover the mechanisms underlying the associations of ambient heat with BP and to describe the clinical consequences of these associations.","PeriodicalId":308,"journal":{"name":"Environment International","volume":"91 1","pages":""},"PeriodicalIF":11.8,"publicationDate":"2024-12-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142816333","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Corrigendum to “Pesticides can be a substantial source of trifluoroacetate (TFA) to water resources” [Environ. Inter. 193 (2024) 109061]
IF 11.8 1区 环境科学与生态学
Environment International Pub Date : 2024-12-12 DOI: 10.1016/j.envint.2024.109198
Hanna Joerss, Finnian Freeling, Stefan van Leeuwen, Juliane Hollender, Xingang Liu, Karsten Nödler, Zhanyun Wang, Bochi Yu, Daniel Zahn, Gabriel Sigmund
{"title":"Corrigendum to “Pesticides can be a substantial source of trifluoroacetate (TFA) to water resources” [Environ. Inter. 193 (2024) 109061]","authors":"Hanna Joerss, Finnian Freeling, Stefan van Leeuwen, Juliane Hollender, Xingang Liu, Karsten Nödler, Zhanyun Wang, Bochi Yu, Daniel Zahn, Gabriel Sigmund","doi":"10.1016/j.envint.2024.109198","DOIUrl":"https://doi.org/10.1016/j.envint.2024.109198","url":null,"abstract":"The authors regret that in the introduction of their recently published paper “Pesticides can be a substantial source of trifluoroacetate (TFA) to water resources”, they mistakenly named fluroxypyr instead of sulfoxaflor as a potential parent compound for TFA formation. The authors hereby wish to correct this mistake.","PeriodicalId":308,"journal":{"name":"Environment International","volume":"3 1","pages":""},"PeriodicalIF":11.8,"publicationDate":"2024-12-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142809824","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Plasticizer exposure in Germany from 1988 to 2022: Human biomonitoring data of 20 plasticizers from the German Environmental Specimen Bank
IF 11.8 1区 环境科学与生态学
Environment International Pub Date : 2024-12-12 DOI: 10.1016/j.envint.2024.109190
Monika Kasper-Sonnenberg, Claudia Pälmke, Sonja Wrobel, Thomas Brüning, Aline Murawski, Petra Apel, Till Weber, Marike Kolossa-Gehring, Holger M. Koch
{"title":"Plasticizer exposure in Germany from 1988 to 2022: Human biomonitoring data of 20 plasticizers from the German Environmental Specimen Bank","authors":"Monika Kasper-Sonnenberg, Claudia Pälmke, Sonja Wrobel, Thomas Brüning, Aline Murawski, Petra Apel, Till Weber, Marike Kolossa-Gehring, Holger M. Koch","doi":"10.1016/j.envint.2024.109190","DOIUrl":"https://doi.org/10.1016/j.envint.2024.109190","url":null,"abstract":"The German Environmental Specimen Bank (ESB) annually archives 24-h urine samples since the early 1980 s. In this study, we analyzed 420 of these samples from the years 2014 to 2022 for metabolites of 18 phthalates and two substitutes. We merged the new with the data from previous measurement campaigns to a combined dataset of 1825 samples covering a 35-year period from 1988 to 2022 to investigate time trends, calculate daily intakes and perform an anti-androgenic mixture risk assessment. With the extended set of 41 biomarkers, we are now able to monitor the exposure to all EU-labelled reprotoxic phthalates. Most phthalate exposures continued to decrease since first measurements in the 80 s, with biggest drops for DnBP (96.6 %) and DEHP (90.9 %). DiNP and DiDP, seen on the rise in earlier campaigns, now declined. Exposures to the newly included, reprotoxic phthalates were generally negligible. Regarding mixture risk, 5 % of the highly exposed still exceeded the Hazard Index (HI) of 1 in 2009. In the current measurement campaign only three individuals (0.7 %) exceeded the HI of 1 (with exceedances still driven by DEHP and DnBP). 2022, 20 % of the individuals still had an HI &gt; 0.2, which we propose as a benchmark for interpreting phthalate mixture risk, considering concurrent exposures to other anti-androgens. Exposure to the substitutes DINCH and DEHTP continues to increase, with daily intakes of DEHTP exceeding those of DEHP since 2018. Compared with the United States (US) National Health and Nutrition Examination Survey (NHANES) phthalate exposures seem to align, except for DEHTP with up to ten times higher levels in the US. Human biomonitoring (HBM) is the ideal tool to capture actual mixture exposures per individual, integrating all external exposure sources and pathways, thus we will continue to use HBM in exposure and risk assessment of phthalates and other (anti-androgenic) chemicals.","PeriodicalId":308,"journal":{"name":"Environment International","volume":"89 1","pages":""},"PeriodicalIF":11.8,"publicationDate":"2024-12-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142809887","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Characteristics and microscopic mechanisms of smoke emissions of OMMT/SBS-modified asphalt
IF 11.8 1区 环境科学与生态学
Environment International Pub Date : 2024-12-12 DOI: 10.1016/j.envint.2024.109192
Wanhong Yang, Zhenghao Zhang, Xiaolong Yang, Xiaofan Jia, Yixin Jiang
{"title":"Characteristics and microscopic mechanisms of smoke emissions of OMMT/SBS-modified asphalt","authors":"Wanhong Yang, Zhenghao Zhang, Xiaolong Yang, Xiaofan Jia, Yixin Jiang","doi":"10.1016/j.envint.2024.109192","DOIUrl":"https://doi.org/10.1016/j.envint.2024.109192","url":null,"abstract":"Nanomaterials are increasingly being used in road engineering with the development of road construction technology. The smoke suppression performance of asphalt can be substantially improved using organic nano-montmorillonite (OMMT)/styrene–butadiene–styrene (SBS) block modifiers. Pyrolysis gas chromatography–mass spectrometry (PY-GC–MS), fluorescence microscopy (FM), thermogravimetric analysis (TG), and gel permeation chromatography (GPC) were used to explore the characteristics and microscopic mechanisms of flue gas emissions. The addition of OMMT effectively reduced the emissions of carbon dioxide and Volatile Organic Compounds (VOCs) in asphalt flue gas, as well as increased the SBS swelling degree in the asphalt matrix and the compatibility between the SBS and asphalt matrix. The stable interlayer structure formed via OMMT/SBS co-modification effectively inhibited the release of VOCs during the thermal decomposition of asphalt, being more environmentally friendly because of the reduction in emissions compared with traditional asphalt. The SBS, OMMT, and asphalt matrix is a physically modified mixture. The incorporation of OMMT increases the macromolecule content in the modified asphalt, showing that OMMT inhibited the decomposition of asphalt macromolecules into smaller molecules, thus reducing the release of VOCs. Including the appropriate macro and small molecules helps strengthen the ability of asphalt to resist permanent deformation at high temperatures, maintain its flexibility, and effectively prevent cracking at low temperatures.","PeriodicalId":308,"journal":{"name":"Environment International","volume":"42 1","pages":""},"PeriodicalIF":11.8,"publicationDate":"2024-12-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142816335","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Corrigendum to “Modelling personal temperature exposure using household and outdoor temperature and questionnaire data: Implications for epidemiological studies” [Environ. Inter. 192 (2024) 109060]
IF 11.8 1区 环境科学与生态学
Environment International Pub Date : 2024-12-12 DOI: 10.1016/j.envint.2024.109196
Xi Xia, Ka Hung Chan, Yue Niu, Cong Liu, Yitong Guo, Kin-Fai Ho, Steve Hung Lam Yim, Baihan Wang, Aiden Doherty, Daniel Avery, Pei Pei, Canqing Yu, Dianjianyi Sun, Jun Lv, Junshi Chen, Liming Li, Peng Wen, Shaowei Wu, Kin Bong Hubert Lam, Haidong Kan, Zhengming Chen
{"title":"Corrigendum to “Modelling personal temperature exposure using household and outdoor temperature and questionnaire data: Implications for epidemiological studies” [Environ. Inter. 192 (2024) 109060]","authors":"Xi Xia, Ka Hung Chan, Yue Niu, Cong Liu, Yitong Guo, Kin-Fai Ho, Steve Hung Lam Yim, Baihan Wang, Aiden Doherty, Daniel Avery, Pei Pei, Canqing Yu, Dianjianyi Sun, Jun Lv, Junshi Chen, Liming Li, Peng Wen, Shaowei Wu, Kin Bong Hubert Lam, Haidong Kan, Zhengming Chen","doi":"10.1016/j.envint.2024.109196","DOIUrl":"https://doi.org/10.1016/j.envint.2024.109196","url":null,"abstract":"The authors regret that the <span><span>supplementary appendix</span></span> was missing from the initial published article due to an unexpected editorial error. This corrigendum provides the <span><span>appendix</span></span> for the article.","PeriodicalId":308,"journal":{"name":"Environment International","volume":"200 1","pages":""},"PeriodicalIF":11.8,"publicationDate":"2024-12-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142809823","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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