Environment International最新文献

{"title":"Seed-borne and environmental transmission mechanisms drive diverse heavy metal-resistant plant growth-promoting bacteria (PGPB) in rice","authors":"Jie Hou ,&nbsp;Mengqi Liu ,&nbsp;Ye Li ,&nbsp;Linyun Li ,&nbsp;Yanpo Yao ,&nbsp;Han Xu ,&nbsp;Yi An","doi":"10.1016/j.envint.2025.109840","DOIUrl":"10.1016/j.envint.2025.109840","url":null,"abstract":"<div><div>Heavy metal-resistant plant growth-promoting bacteria (PGPB) play a crucial role in mitigating heavy metal stress and reducing heavy metal accumulation in plants. However, the origins and transmission mechanisms of PGPB and their associated heavy metal resistance genes (MRGs) in plants remain unclear. To fill this knowledge gap, we collected rice and related environmental samples from heavy metal-contaminated paddy fields. The microbial DNA was recovered from these rice and environmental samples and then analyzed using shotgun metagenomics at the metagenome-assembled genomes (MAGs) level. As a result, 805 MRG-PGPB combinations were detected in rice tissues and related environments under heavy metal contamination conditions. Core MRG-PGPB combinations shared across seed-rice (42.46%) and environment-rice (13.34%) interfaces collectively constituted 55.80% of the detected combinations, demonstrating that environmental translocation and seed-borne vertical transmission jointly drive over half of MRG-PGPB colonization in rice systems. Subsequent source-tracking analysis indicated that PGPBs present in rice primarily originated from seeds, with a substantial proportion also attributed to translocation within rice tissues. Phylogenetic analysis of dominant MRGs further demonstrated the seed-borne vertical transmission of MRGs-PGPB, while simultaneously elucidating that MRGs harbored by PGPB in rice could also be acquired via horizontal gene transfer (HGT) from environmental or seed-borne MRG-PGPB, particularly from atmospheric microbes such as <em>Methylophilus</em> and <em>Serratia</em>. These findings provide valuable insights into harnessing PGPB to enhance rice resilience against heavy metal contamination, thereby contributing to improved food security and sustainable agricultural practices.</div></div>","PeriodicalId":308,"journal":{"name":"Environment International","volume":"204 ","pages":"Article 109840"},"PeriodicalIF":9.7,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145209602","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Enhanced wastewater surveillance of respiratory viruses: Unraveling partitioning behavior and demixing co-circulating lineages","authors":"Xiaoyi Lu ,&nbsp;Zhenyu Guo ,&nbsp;Langjun Tang,&nbsp;Junqiao Zhao,&nbsp;Yonghong Li,&nbsp;Kun Yang","doi":"10.1016/j.envint.2025.109836","DOIUrl":"10.1016/j.envint.2025.109836","url":null,"abstract":"<div><div>Wastewater-based epidemiology (WBE) enables community-level pathogen surveillance, yet incomplete understanding of viral partitioning behavior complicates strategy optimization and data interpretation. We demonstrated that pH and surfactants critically govern viral distribution between wastewater phases. Despite high solid–liquid partition coefficients, viruses predominantly reside in the liquid phase due to wastewater’s low solid content (10²-10³ mg/L). Leveraging these insights, we conducted one-year RT-qPCR surveillance across Sichuan University and Chengdu, capturing two SARS-CoV-2 waves and an influenza A outbreak. To address lineage demixing challenges from suboptimal sequencing, we developed NextVpower, a deconvolution tool resolving co-circulating lineages while tracking critical mutations for clinical early-warning. Notably, NextVpower achieved the first demixing of both HA- and NA-lineages for H3N2 influenza A virus in wastewater. This advances WBE’s capacity to link wastewater-derived mutations to epidemiological trends, enhancing real-time outbreak preparedness through optimized viral recovery and lineage-resolved analytics.</div></div>","PeriodicalId":308,"journal":{"name":"Environment International","volume":"204 ","pages":"Article 109836"},"PeriodicalIF":9.7,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145203349","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Decoupling total accumulation from ecological and health risks: speciation stabilization of heavy metal(loid)s in soil-maize systems under 16-year application of various organic fertilizers","authors":"Ling Zhang ,&nbsp;Wentao Xue ,&nbsp;Qinping Sun ,&nbsp;Baocun Liu ,&nbsp;Yuncai Hu ,&nbsp;Hao Sun ,&nbsp;Shanjiang Liu ,&nbsp;Junxiang Xu ,&nbsp;Guoyuan Zou","doi":"10.1016/j.envint.2025.109830","DOIUrl":"10.1016/j.envint.2025.109830","url":null,"abstract":"<div><div>Long-term application of organic composts is known to enhance soil heavy metal (loid)s (HMs) accumulation; yet the dynamic speciation-bioaccumulation-health risks affected by various organic composts remain unclear. To address this knowledge gap, a 16-year field experiment assessed the effects of chicken manure (CM), sewage sludge composts (SSC), and domestic waste composts (DWC) on the accumulation, speciation, and bioavailability of eight HMs in a soil-maize system. The results showed that continuous application of CM, SSC, and DWC at 6 t ha⁻¹ increased soil concentrations of Cd by 20–38 %, Cr by 8–16 %, Cu by 9–21 %, Zn by 17–37 %, and Hg by 82–350 % compared to control or chemical fertilizer treatments, with SSC showing the highest Hg accumulation (306–350 % increase). A moderate ecological risk was observed in SSC-treated plots, while other treatments posed low ecological risks. Organic fertilizer application promoted the HM stabilization: e.g. the proportion of stable fraction for Cd increased from 64 to 65–70 % under organic treatments. Such stabilization reduced bioaccumulation factors of Hg, Cd, and Zn by 42–78 %, resulting in no significant increase in HM concentrations in maize grains or health risks. Safe application durations are first estimated as 117 and 131 years for CM and SSC application (limited by Zn), respectively, and theoretically unlimited for DWC. The study concludes that stabilization of HM speciation and regulated application rates of organic fertilizers can decouple total HM accumulation from ecological and health risks. These findings provide practical guidance for the sustainable recycling of organic waste resources while ensuring environmental and food safety.</div></div>","PeriodicalId":308,"journal":{"name":"Environment International","volume":"204 ","pages":"Article 109830"},"PeriodicalIF":9.7,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145226729","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prenatal exposure to arsenic in drinking water and type 1 diabetes in a nationwide population-based cohort of Danish children","authors":"Thoranna Gilbertsdottir ,&nbsp;Louise Lindholdt ,&nbsp;Birgitte Hansen ,&nbsp;Denitza Voutchkova ,&nbsp;Torben Sigsgaard ,&nbsp;Jörg Schullehner","doi":"10.1016/j.envint.2025.109795","DOIUrl":"10.1016/j.envint.2025.109795","url":null,"abstract":"<div><h3>Background</h3><div>Exposure to inorganic arsenic during pregnancy has been associated with immune dysregulation and shifts in leukocyte subpopulations critically involved in the pathogenesis of type 1 diabetes (T1D).</div></div><div><h3>Objectives</h3><div>This study explores the association between prenatal drinking water arsenic exposure and the autoimmune disease T1D in Danish children.</div></div><div><h3>Methods</h3><div>Prenatal arsenic exposure from household drinking water was linked with information on T1D diagnoses from The Danish National Patient- and Prescription Registries. All singleton births from 2002 to 2012, located from The Danish Medical Birth Registry, and living in a household using a public water supply, were included. Cox proportional hazards models were used with age as underlying time scale and adjusted for calendar year, sex at birth, maternal age, smoking status, BMI, parental T1D status, education and income.</div></div><div><h3>Results</h3><div>In a total of 563,871 births, a positive association between prenatal arsenic drinking water exposure and T1D was observed. In fully adjusted models using &lt;1 µg/L as reference, a monotonically increasing association was observed, HR (95 % CI): 1.10 (0.98–1.24), 1.29 (0.88–1.87) and 2.04 (1.15–3.60) for 1–5, 5–10, and ≥10 µg/L, respectively. A higher risk was observed among children born above median compared with below median birth weight across all exposure categories.</div></div><div><h3>Discussion</h3><div>To our knowledge, this is the first study to investigate the association between prenatal arsenic exposure from drinking water and T1D. We found that low levels of arsenic during pregnancy increased risk of T1D in public supply users, highlighting arsenic as a potential modifiable risk factor for T1D.</div></div>","PeriodicalId":308,"journal":{"name":"Environment International","volume":"204 ","pages":"Article 109795"},"PeriodicalIF":9.7,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145067770","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exogenous chemical exposures and metabolic disruptions in hyperuricemia: a multi-omics mediation study","authors":"Yang Ouyang ,&nbsp;Lvyun Sun ,&nbsp;Di Yu ,&nbsp;Qi Li ,&nbsp;Shanshan Du ,&nbsp;Xiaolin Wang ,&nbsp;Mengyao Wang ,&nbsp;Guowang Xu ,&nbsp;Weimin Ye ,&nbsp;Xinyu Liu","doi":"10.1016/j.envint.2025.109832","DOIUrl":"10.1016/j.envint.2025.109832","url":null,"abstract":"<div><h3>Background</h3><div>Hyperuricemia has emerged as a significant public health concern. However, the relationship between hyperuricemia and both individual and mixed exogenous chemicals remains poorly understood, and the underlying mechanisms are still unclear.</div></div><div><h3>Objectives</h3><div>This study aimed to elucidate the risk factors and biological mechanisms underlying hyperuricemia by integrating multi-omics data.</div></div><div><h3>Methods</h3><div>UPLC-MS-based methods were employed to quantify 186 exogenous chemicals and profile metabolites from serum samples of 298 pairs of hyperuricemia patients and matched control subjects.</div></div><div><h3>Results</h3><div>Significant disturbances in amino acid metabolism, energy metabolism, and gut microbiota-related metabolism were observed in hyperuricemia patients. The concentrations of perfluoroheptanoic acid, perfluorobutanesulfonate, sodium 4-chlorophenoxyacetate, and indole-3-butyric acid were significantly higher in hyperuricemia patients. A positive association was observed between combined exposures and hyperuricemia risk, with indole-3-butyric acid being the most significant contributor. Perfluorinated compounds may affect uric acid excretion via gut microbiome-related metabolites. Indole-3-butyric acid might modulate the enzymatic activity of various acyl-CoA dehydrogenases, leading to disruptions in fatty acid metabolism and an increased risk of hyperuricemia. Furthermore, genetic susceptibility appears to further increase the risk of hyperuricemia.</div></div><div><h3>Conclusions</h3><div>In summary, hyperuricemia is related to the interplay of environmental exposures and individual genetic susceptibility, with metabolic dysregulation serving as a crucial mediating link. These findings offer novel insights into the potential health risks associated with exogenous chemical exposures.</div></div>","PeriodicalId":308,"journal":{"name":"Environment International","volume":"204 ","pages":"Article 109832"},"PeriodicalIF":9.7,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145188853","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Combination of effect-based monitoring and targeted screening of (drinking)water II: Effect directed analysis of compounds responsible for bioassay activity","authors":"Corine J. Houtman, Carla van der Neut-Marchand, Yvonne G.M. van Oorschot, Marja H. Lamoree, Ruud J.C.A. Steen","doi":"10.1016/j.envint.2025.109782","DOIUrl":"https://doi.org/10.1016/j.envint.2025.109782","url":null,"abstract":"Bioassays are increasingly applied in the monitoring of chemical water quality. To determine whether elevated bioassay activities indicate a risk, identification of the active substances is needed. This study investigated the presence and fate of 10 biological activities detected by CALUX bioassays and chemical contaminants detected by targeted screening in sources and treatments of drinking water companies in the Dutch parts of the Rhine and Meuse catchments. This was reported in the accompanying article. As the correlations elucidated by the hierarchical cluster analysis approach did not in all cases reveal the causative compounds, effect directed analysis (EDA) was performed and reported in this article. By embedding the p53 and the Nrf2 CALUX bioassays (for genotoxicity and oxidative stress, respectively) in an earlier developed high throughput EDA platform, the identification of contributors to multiple different endpoints was achieved. The platform combined microfractionation, miniaturised bioassays and targeted screening using high resolution mass spectrometry, and was applied to eight samples. Natural and synthetic steroid hormones and their metabolites were identified as contributors to androgenic, estrogenic, glucocorticoid and progestogenic activities. Fourteen pesticides were found to contribute to anti-androgenic, anti-progestogenic and/or cytotoxic activities, underlining the increasing public concern of pesticide use. Two pharmaceuticals contributed to oxidative stress in the WWTP effluent sample. Although the p53 CALUX assay was successfully integrated in the EDA platform, is was not applied to water samples due to lack of detectable activity. The applied EDA platform proved to be powerful to identify bioactive compounds in water with a high endpoint coverage in a high throughput format. EDA creates an integrated and risk-based view on those contaminants that deteriorate chemical water quality.","PeriodicalId":308,"journal":{"name":"Environment International","volume":"99 1","pages":""},"PeriodicalIF":11.8,"publicationDate":"2025-09-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145153830","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Overlooked crisis: cold temperature amplifies particle number emissions from gasoline vehicles","authors":"Xihui Tong ,&nbsp;Haiguang Zhao ,&nbsp;Yongshuai Qu ,&nbsp;Jie Yao ,&nbsp;Jia Ke ,&nbsp;Junchao Zhao ,&nbsp;Tianyu Zhai ,&nbsp;Xin Li ,&nbsp;Xinping Yang ,&nbsp;Yunjing Wang ,&nbsp;Hang Yin ,&nbsp;Yan Ding","doi":"10.1016/j.envint.2025.109818","DOIUrl":"10.1016/j.envint.2025.109818","url":null,"abstract":"<div><div>This study systematically investigates particle number (PN) emissions from light-duty gasoline vehicles through chassis dynamometer (60 emission test runs spanning −7 °C to 40 °C) combined with mechanistic analysis, revealing a severely underestimated “cold-temperature penalty” effect. While gasoline direct injection (GDI) engine technology improves fuel economy, it significantly amplifies PN emissions, particularly during cold startup mode, where GDI-equipped internal combustion engine vehicles (ICEVs) without gasoline particulate filters (GPFs) emitted PN levels up to 10 times higher than during hot startup operation at 23 °C. GPF installation demonstrated substantial PN reduction benefits, with its emission control efficacy surpassing the motor auxiliary mitigation effect of hybrid electric vehicles (HEVs). Notably, PFI-equipped HEVs without GPFs emitted around 7 times higher PN emissions than PFI-equipped ICEVs with GPFs at 23 °C conditions, challenging the conventional belief that “electrification equals cleanliness”. Additionally, we quantified medium-speed emission migration in HEVs, exposing hidden pollution risks during motor-engine transition. A critical combustion efficiency threshold of 0.99 was identified as a regulatory pivot for the non-monotonic relationship between PN emissions and combustion efficiency, offering a new optimization target for emission control systems. An exponential correlation between equivalent mileage ratio (EMR) and ambient temperature was established, showing that even at 20 °C, GDI-equipped ICEVs without GPFs exhibited EMR values as high as 50, indicating that 1 km of cold-start PN emissions equals 50 km of hot-stabilized operation, highlighting a regulatory blind spot in current emission standards for cold regions. These findings provide scientific insights for combustion optimization and after-treatment design under extreme climates while underscoring the urgency of prioritizing GDI-equipped vehicles without GPFs in emission regulations for cold temperature zones.</div></div>","PeriodicalId":308,"journal":{"name":"Environment International","volume":"204 ","pages":"Article 109818"},"PeriodicalIF":9.7,"publicationDate":"2025-09-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145134402","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"One-year dynamics of atmospheric organophosphate esters: Size-fractionated distribution, seasonal trends, and machine learning-based driver identification","authors":"Shu-Qing Qiu ,&nbsp;Li-Xin Hu ,&nbsp;Yan-Jun Tang ,&nbsp;Cheng-Lei Pei ,&nbsp;Da-Chi Hong ,&nbsp;She-Jun Chen ,&nbsp;Guang-Guo Ying","doi":"10.1016/j.envint.2025.109815","DOIUrl":"10.1016/j.envint.2025.109815","url":null,"abstract":"<div><div>Organophosphate esters (OPEs) have increasingly raised global concern due to their pervasive presence in airborne particles and potential risks they pose to human health. This study systematically characterized OPE concentrations in PM_2.5, PM₁₀, and TSP over a one-year period. The results revealed that OPEs preferentially partitioned to smaller particles and displayed higher total concentrations during the warm season. Among alkyl-, halogenated-, and aryl-OPEs, halogenated-OPEs exhibited the highest concentrations while aryl-OPEs ranked highest in ToxPi-based prioritization. To identify key environmental drivers, Random Forest model combined with SHAP analysis and structural equation model were employed. The RF-SHAP model demonstrated higher explanatory power for halogenated-OPEs compared to alkyl- and aryl-OPEs, with temperature, atmospheric pressure, and the interaction effect of temperature and relative humidity identified as dominant influencing factors. Furthermore, the findings suggest that OPEs may undergo atmospheric transformation under complex environmental conditions. Overall, this study provides a comprehensive understanding of the particle-size distribution, temporal dynamics, environmental determinants, and health risk profiles associated with particle-bound OPEs. These insights are invaluable for informing future regulations concerning emerging contaminants in the atmosphere.</div></div>","PeriodicalId":308,"journal":{"name":"Environment International","volume":"204 ","pages":"Article 109815"},"PeriodicalIF":9.7,"publicationDate":"2025-09-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145134352","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Women’s health and wellbeing prioritisation in climate change national adaptation plans: A cross-sectional policy document analysis across 163 countries","authors":"Ana-Catarina Pinho-Gomes ,&nbsp;Gabriela Cipriano Flores ,&nbsp;Rachel Hulme ,&nbsp;Jessica Gong ,&nbsp;Jane Hirst ,&nbsp;Alice Witt ,&nbsp;Kate Womersley ,&nbsp;Celestine Donovan-Bradley ,&nbsp;Edward Mullins","doi":"10.1016/j.envint.2025.109811","DOIUrl":"10.1016/j.envint.2025.109811","url":null,"abstract":"<div><h3>Background</h3><div>Although the gendered impact of climate change is increasingly recognised, its inclusion in national adaptation plans (NAPs) remains unclear. This study investigated how the health, wellbeing and welfare of women are accounted for in climate NAPs published by 163 countries worldwide and identified the key thematic areas where the needs of women have been considered.</div></div><div><h3>Methods</h3><div>NAPs were analysed across ten domains: health, gender-based violence, education, economy, power, food, environment, Emergency Preparedness, Resilience, and Response, and research and policy and 15 subdomains. Quantitative scoring used a 4-level Likert scale (none, minimal, some and substantial) for a maximum of 75 points. Content analysis was undertaken to identify themes for women’s inclusion.</div></div><div><h3>Findings</h3><div>Overall, countries in Sub-Saharan Africa and Latin America and the Caribbean achieved the highest total scores (median 7.0 points), whilst Central Asia and East Asia and the Pacific achieved the lowest total scores (median 1.5 and 2.5 points, respectively). At country level, the total score ranged from 0 points for 43 countries to 56 points in Bangladesh and the median score was 28 points. The quality analysis identified the inclusion of women in policy making, the consideration of gender as an important determinant of vulnerability, and the collection and of gender-disaggregated data. Women’s vulnerability was considered across four themes: biophysiological, socioeconomic, type of work, and gender inequalities.</div></div><div><h3>Interpretation</h3><div>Consideration of women’s health, wellbeing and welfare in NAPs worldwide remains limited with a significant number of countries lacking any mention to women or gender. Further research is warranted to investigate whether policy commitments in NAPs are implemented and translate into improvement of women’s lives.</div></div>","PeriodicalId":308,"journal":{"name":"Environment International","volume":"204 ","pages":"Article 109811"},"PeriodicalIF":9.7,"publicationDate":"2025-09-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145127867","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Environmental di-(2-ethylhexyl) phthalate exposure accelerates lipid metabolism disorders via the gut-fat axis in male SAMP8 mice: role of gut microbiota and thyroid hormone signaling","authors":"Sheng-long Cao ,&nbsp;Yan Shen ,&nbsp;Xiao-han Yang ,&nbsp;Gang Zhang ,&nbsp;Yi-jun Zhang ,&nbsp;Yán Wāng ,&nbsp;Fang-Biao Tao ,&nbsp;Qu-Nan Wang","doi":"10.1016/j.envint.2025.109808","DOIUrl":"10.1016/j.envint.2025.109808","url":null,"abstract":"<div><div>Di-(2-ethylhexyl) phthalate (DEHP) is a widely used environmental endocrine disruptor and a potential obesogen. Its pervasive presence in pharmaceutical and personal care products (PPCPs), along with the associated ecological and health risks, has attracted growing scientific concern. Building on our previous findings linking DEHP exposure to an increased risk of obesity in elderly humans, this study investigated the effects of DEHP on lipid metabolism in adipose tissue during aging. Male senescence-accelerated prone (SAMP8) mice were orally administered DEHP (0, 0.2, or 200 mg/kg/day) for five weeks. DEHP exposure significantly increased body weight and induced adipocyte hypertrophy, particularly at the lower dose. It also suppressed systemic energy metabolism and impaired thermogenic function in brown adipose tissue (BAT). In epididymal white adipose tissue (eWAT), DEHP promoted lipid accumulation and disrupted lipidomic profiles. Moreover, DEHP altered gut microbiota composition, reducing α- and β-diversity, and notably increasing the abundance of <em>Prevotellaceae_UCG-001</em>, which was positively correlated with elevated triglyceride levels in eWAT. Concurrently, DEHP exposure downregulated the mRNA and protein expression of deiodinases and thyroid hormone receptors in adipose tissues, indicating suppression of local thyroid hormone signaling. Taken together, these findings demonstrate that DEHP exposure disrupts lipid metabolism via alterations in the gut-fat axis, mediated by gut microbiota dysbiosis and impaired thyroid hormone signaling, ultimately contributing to obesity development in aging SAMP8 mice.</div></div>","PeriodicalId":308,"journal":{"name":"Environment International","volume":"204 ","pages":"Article 109808"},"PeriodicalIF":9.7,"publicationDate":"2025-09-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145116932","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}