Environment International最新文献

{"title":"Interactions between agrochemicals and parasites endangering insect populations","authors":"Davide Frizzera ,&nbsp;Verena Strobl ,&nbsp;Orlando Yañez ,&nbsp;Elisa Seffin ,&nbsp;Virginia Zanni ,&nbsp;Desiderato Annoscia ,&nbsp;Peter Neumann ,&nbsp;Francesco Nazzi","doi":"10.1016/j.envint.2025.109664","DOIUrl":"10.1016/j.envint.2025.109664","url":null,"abstract":"<div><div>There is clear evidence for declines of wild insects and high losses of managed ones, thereby threatening their key ecosystem services. Interactions among stressors such as agricultural intensification and invasive species have been implicated in these declines. However, both the nature of these interactions as well as the actual outcomes are often poorly understood. This holds true for ubiquitous agrochemicals and ectoparasitic <em>Varroa destructor</em> mites, and losses of managed honey bee, <em>Apis mellifera,</em> colonies. Here, we show that two pesticides (sulfoxaflor and coumaphos) can enhance parasite reproduction, thereby contributing to host colony losses. A gene expression study revealed a consistent effect on key genes in the hormonal pathways regulating honey bee development, thereby suggesting a link with parasite reproduction. Because all animals have parasites and are exposed to such agrochemicals even in nature reserves, this mechanism could be relevant for a wide range of insect species and may represent a serious threat for their conservation.</div></div>","PeriodicalId":308,"journal":{"name":"Environment International","volume":"202 ","pages":"Article 109664"},"PeriodicalIF":10.3,"publicationDate":"2025-07-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144566277","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of maternal bisphenol exposure on adverse pregnancy and neonatal outcomes: The Japan Environment and Children’s study","authors":"Mayumi Sugiura-Ogasawara ,&nbsp;Neeranuch Suwannarin ,&nbsp;Hazuki Tamada ,&nbsp;Takeshi Ebara ,&nbsp;Yuki Ito ,&nbsp;Shoji F. Nakayama ,&nbsp;Mai Takagi ,&nbsp;Shinji Saitoh ,&nbsp;Michihiro Kamijima ,&nbsp;the Japan Environment, Children’s Study Group","doi":"10.1016/j.envint.2025.109663","DOIUrl":"10.1016/j.envint.2025.109663","url":null,"abstract":"<div><div>Maternal exposure to bisphenols, including bisphenol A (BPA), reportedly results in adverse pregnancy and offspring health outcomes. However, large birth cohort studies on the risk of BPA exposure during pregnancy remain limited. Here, we examined bisphenols’ effects on adverse pregnancy and neonatal outcomes using data from the Japan Environment and Children’s Study, a nationwide birth cohort study.</div><div>We selected 4523 women with pregnancies resulting in singleton live births. First-trimester urine concentrations of bisphenols A, F, S, and AF were determined via high-performance liquid chromatography-tandem mass spectrometry. We analyzed the association between BPA exposure and preterm birth, hypertensive disorders of pregnancy, gestational diabetes mellitus, small- and large-for-gestational-age infants, low birth weight, offspring physical and chromosome abnormalities using Bayesian logistic regression analysis after applying the GSimp imputation method for concentrations within the minimum reporting limit.</div><div>Bisphenol detection rates were generally low (0.0–11.9 % of samples), except for that of BPA (71.5 %), and BPA concentrations were lower than those reported in previous international studies. The estimated BPA daily intake for 86.6 % of the study participants exceeded the European Food Safety Authority’s tolerable daily intake (0.0002 µg/kg/day). However, BPA intake was not significantly associated with any outcome.</div><div>These findings suggest that BPA’s current exposure levels do not affect measured pregnancy and neonate outcomes in Japan. Here, although BPA levels reflect only recent exposure, the potential health risks associated with BPA underscore the need for further research to investigate the long-term effects of low-level exposure on maternal and child health.</div></div>","PeriodicalId":308,"journal":{"name":"Environment International","volume":"202 ","pages":"Article 109663"},"PeriodicalIF":10.3,"publicationDate":"2025-07-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144566224","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Source-specific nitrate and nitrite intake and association with colorectal cancer in the Danish Diet, Cancer and Health Cohort","authors":"Dorit W. Erichsen ,&nbsp;Nicola P. Bondonno ,&nbsp;Pratik Pokharel ,&nbsp;Susanne Rosthøj ,&nbsp;Catherine P. Bondonno ,&nbsp;Liezhou Zhong ,&nbsp;Jörg Schullehner ,&nbsp;Torben Sigsgaard ,&nbsp;Peter Fjeldstad Hendriksen ,&nbsp;Frederik Dalgaard ,&nbsp;Ole Raaschou-Nielsen ,&nbsp;Jonathan M. Hodgson ,&nbsp;Christina C. Dahm ,&nbsp;Anja Olsen ,&nbsp;Anne Tjønneland ,&nbsp;Cecilie Kyrø","doi":"10.1016/j.envint.2025.109658","DOIUrl":"10.1016/j.envint.2025.109658","url":null,"abstract":"<div><h3>Introduction</h3><div>Nitrate and nitrite, present in food and drinking water, may contribute to colorectal cancer (CRC) through the formation of carcinogenic N-nitroso compounds (NOCs). This study examined source-specific associations with CRC and subtypes, considering potential dietary and lifestyle factors that influence NOC formation.</div></div><div><h3>Methods</h3><div>In the Danish Diet, Cancer, and Health Cohort (N=54,610), nitrate/nitrite intake was estimated from comprehensive databases and national monitoring data. Over 27 years, 2245 CRC cases (1508 colon and 737 rectal) were identified via the Danish Cancer Registry. Cox proportional hazards models adjusted for sociodemographic, diet, and lifestyle factors were used to examine associations, with stratified analyses by sex and factors influencing NOC formation.</div></div><div><h3>Results</h3><div>No associations were found between nitrate/nitrite intakes from plant, naturally-occurring animal sources, or additive-permitted meat sources and CRC. However, higher nitrate intake from tap water (mg/d) was associated with a higher rate of distal colon cancer [HR_Q5vQ1 (95% CI); 1.48 (1.11, 1.97)], though not CRC overall. A nitrate concentration in tap water ≥9.25 mg/L was linked to a higher colon cancer rate [HR 1.52 (1.11, 2.07)] compared to &lt;1.27 mg/L. This association appeared stronger in individuals with risk-promoting factors (smoking and high red meat intake) and weaker among those with a high intake of NOC inhibiting factors (vitamin C, vitamin E, folate, and flavonoids).</div></div><div><h3>Conclusion</h3><div>Nitrate/nitrite intakes from food sources were not associated with rate of CRC in the cohort, but tap water nitrate, at higher intake levels and at concentrations over ≥9.25 mg/L were linked to higher rates of distal colon and colon cancer, respectively.</div></div>","PeriodicalId":308,"journal":{"name":"Environment International","volume":"202 ","pages":"Article 109658"},"PeriodicalIF":10.3,"publicationDate":"2025-07-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144566402","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Development of SOA modules in the WRF-Chem model and evaluation of the key formation pathways of SOA and associated health risk over mainland China","authors":"Liqing Wu ,&nbsp;Bing Wu ,&nbsp;Zhenhao Ling ,&nbsp;Min Shao ,&nbsp;Xuemei Wang","doi":"10.1016/j.envint.2025.109662","DOIUrl":"10.1016/j.envint.2025.109662","url":null,"abstract":"<div><div>Secondary Organic Aerosol (SOA), a vital component of fine particulate matter (PM_2.5), formation of which is significantly affected by precursors, meteorological factors and the levels of oxidants. However, identifying their roles in SOA and PM_2.5, as well as quantifying the contributions of the individual pathway to SOA abundance still remain challenged due to the complex origins and degradation mechanisms, as well as the discrepancy between the simulated and observed SOA. Here, a commonly used WRF-Chem model was further optimized for SOA simulation. The improvements included the integration of primary emissions and the degradation of S/IVOCs, aqueous chemistry of carbonyl compounds, chlorine chemistry, cloud aqueous chemistry, and SOA wet deposition processes. The optimized model was used to evaluate the key SOA formation pathways and their impact factors, as well as the associated health risk during pollution episodes. The dominant factors of the aqueous chemistry of carbonyl compounds, chlorine chemistry module, Cl-initiated SOA-forming pathway, cloud aqueous chemistry and wet deposition that influenced SOA abundance were aerosol water, volatile organic compounds (VOCs), Cl atom, temperature, respectively. The key formation pathways leading to SOA pollution were the gas-phase oxidation of semi-volatile/intermediate-volatility organic compounds (S/IVOCs) and the aqueous-phase chemistry of carbonyl compounds over mainland China. The regional average attributable fraction of mortality was approximately 0.03, with the largest contributions from the reaction pathways of S/IVOCs and carbonyl compounds. Therefore, reducing emissions of S/IVOCs and carbonyl compounds is vital to mitigating SOA and PM_2.5 concentrations, achieving air quality standards, and protecting public health.</div></div>","PeriodicalId":308,"journal":{"name":"Environment International","volume":"202 ","pages":"Article 109662"},"PeriodicalIF":10.3,"publicationDate":"2025-07-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144547353","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The relationship between chronic air pollution exposure, neighborhood environmental vulnerability, and adverse COVID-19 morbidities among hospitalized New York City residents","authors":"Sneha Kannoth ,&nbsp;Cong Zhang ,&nbsp;Mehr Shafiq ,&nbsp;Sandra S. Albrecht ,&nbsp;Alexander Azan ,&nbsp;Earle C. Chambers ,&nbsp;Min Qian ,&nbsp;Perry E. Sheffield ,&nbsp;Azure Thompson ,&nbsp;Jennifer A. Woo Baidal ,&nbsp;Stephanie Lovinsky-Desir ,&nbsp;Jeanette A. Stingone","doi":"10.1016/j.envint.2025.109660","DOIUrl":"10.1016/j.envint.2025.109660","url":null,"abstract":"<div><h3>Introduction</h3><div>Communities disproportionately burdened by adverse neighborhood-level social and structural factors may experience greater vulnerability to environmental exposures, contributing to health inequities, including adverse COVID-19. We assessed the effects of chronic air pollution on COVID-19 morbidities in NYC and examined whether these effects varied by neighborhood-level vulnerability.</div></div><div><h3>Methods</h3><div>We used NYC COVID-19 hospitalization records (3/1/2020–2/28/2021) and conducted analyses in the full sample and within hospital catchment. Chronic air pollution (particulate matter (PM_2.5), nitrogen dioxide (NO₂), black carbon (BC), ozone (O₃)) was assigned using residential ZIP Code (NYC Community Air Survey; 2009–2019). Modified Poisson regression estimated risk of acute respiratory distress syndrome (ARDS), pneumonia, ventilation, and dialysis, and Cox regression estimated risk of discharge, adjusting for age, sex, BMI, smoking, asthma, diabetes, and hypertension. We assessed effect modification by neighborhood-level environmental vulnerability index (NEVI) tertiles.</div></div><div><h3>Results</h3><div>From March to June 2020 (within hospital catchment), adjusted estimates generally suggest greater chronic NO₂, PM_2.5, and BC was associated with increased risk of ARDS, pneumonia, and dialysis, and not associated with discharge and ventilation; inverse estimates found for chronic O₃. Relationships between air pollution and adverse COVID-19 were generally stronger among those with greater neighborhood environmental vulnerability. For example, chronic NO₂ and pneumonia’s relationship was stronger in individuals within higher NEVI tertiles (T1: aRR: 1.13, 95%CI: 1.02–1.25; T2: aRR: 2.11, 95%CI: 1.73–2.56; T3: aRR: 6.36, 95%CI: 4.71–8.60).</div></div><div><h3>Discussion</h3><div>Differences in neighborhood-level social and structural factors contribute to unequal health burdens associated with air pollution. Public health resources targeted toward neighborhoods with greater environmental vulnerability can encourage population-level pandemic preparedness.</div></div>","PeriodicalId":308,"journal":{"name":"Environment International","volume":"202 ","pages":"Article 109660"},"PeriodicalIF":10.3,"publicationDate":"2025-07-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144547602","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Health risks related to air pollution by transport categories and vehicle types: Comparison by mortality indicators","authors":"Otto Hänninen ,&nbsp;Heli Lehtomäki ,&nbsp;Antti Korhonen ,&nbsp;Tuukka Kokkola ,&nbsp;Anni Hartikainen ,&nbsp;Olli Sippula ,&nbsp;Ulla Haverinen-Shaughnessy ,&nbsp;Pekka Leviäkangas ,&nbsp;Isabell Katharina Rumrich","doi":"10.1016/j.envint.2025.109657","DOIUrl":"10.1016/j.envint.2025.109657","url":null,"abstract":"<div><h3>Background</h3><div>The transports are challenged by the need of sustainable, energy-efficient, and pollution-free services. Environmental epidemiology has confirmed substantial health impacts from traffic fine particles (PM_2.5) and nitrogen dioxide (NO₂), but emerging evidence suggests additional burden due to black carbon (BC), ultrafine particles (UFP), and secondary organic aerosols (SOA). Our aim is to make an overview of the potential transport sector air pollution health risks remaining after implementing most of the current legislation by EU27 in 2030.</div></div><div><h3>Methods</h3><div>We extend the established emission-intake-effect framework and apply exposure efficiencies by vehicle types and use effect factors estimated from epidemiological relative risks for each pollutant to calculate attributable mortalities by vehicle types, fuels, and non-exhaust emissions.</div></div><div><h3>Results</h3><div>Our results suggest that in 2030, primary fine particle (pPM_2.5) emissions from the transport sector may still be responsible for 10,296 (95% CI 7867–11,476) premature deaths in EU27. When compared with alternative air pollution indicators, estimates were 18,686 (9436–36,654) for nitrogen dioxide, 5037 (2446–7620) for black carbon, and 1476 (1017–1956) for secondary organic aerosols. However, largest single pollutant mortality estimate was calculated for ultrafine particles (37,582 (31,569–43,219)). Road traffic and diesel exhausts stand out as dominant sources.</div></div><div><h3>Discussion</h3><div>These emissions seem central for targeting effective control policies. However, toxicological evidence needs to be incorporated with the current epidemiology-based multipollutant indicators. Variable extent and consistency of epidemiological evidence on the five pollutants should be considered when interpreting these results.</div></div>","PeriodicalId":308,"journal":{"name":"Environment International","volume":"202 ","pages":"Article 109657"},"PeriodicalIF":10.3,"publicationDate":"2025-07-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144533698","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Application of traditional and reverse labeling approaches to assess dietary bioavailability of metals in biofilms","authors":"Yunuo Duan ,&nbsp;Shiqi Zhu ,&nbsp;Yuxuan Song ,&nbsp;Dan Zhu ,&nbsp;Mei Zhong ,&nbsp;Liqiang Chen ,&nbsp;Xia Luo","doi":"10.1016/j.envint.2025.109648","DOIUrl":"10.1016/j.envint.2025.109648","url":null,"abstract":"<div><div>The accuracy of stable isotope tracing techniques, traditional and reverse labeling, in evaluating metal bioavailability remains uncertain. This study employed pulse-chase feeding combined with multi-heavy-metal stable isotope labeling to compare the effectiveness of these methods in assessing Zn, Cr, and Pb bioavailability in natural biofilms consumed by the Chinese mystery snail (Cipangopaludina chinensis). Results showed that the waterborne uptake rate constants of ⁶⁷Zn and ²⁰⁴Pb were higher than the dietborne uptake rate constants (<span><math><msub><mi>k</mi><mrow><mi>uf</mi></mrow></msub></math></span>) for both labeling techniques. However, metal accumulation by C. chinensis through dietborne uptake, as determined using reverse labeling, was markedly greater than accumulation via the waterborne uptake route. Reverse labeling <span><math><msub><mi>k</mi><mrow><mi>uf</mi></mrow></msub></math></span> values for ⁶⁷Zn, ⁵³Cr, and ²⁰⁴Pb were 5 %, 12 %, and 21 % higher, respectively, than those from traditional labeling. Despite these differences, both labeling techniques revealed the high bioavailability of heavy metals in biofilms to C. chinensis. Heavy metal assimilation efficiency and ingestion rates were consistent across labeling techniques. Furthermore, neither individual nor multi-metal exposure affected net accumulation, assimilation efficiency, and ingestion rates for metals in biofilms under the same labeling method. This study highlights the utility of stable isotope labeling in bioavailability assessments while emphasizing method variations.</div></div>","PeriodicalId":308,"journal":{"name":"Environment International","volume":"202 ","pages":"Article 109648"},"PeriodicalIF":10.3,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144533700","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Data-driven risk assessment of antibiotic mixtures against gram-negative and gram-positive bacteria: QSAR, joint toxic action, and component contribution","authors":"Haoyu Sun ,&nbsp;Fangyu Xu ,&nbsp;Ruijia Luo ,&nbsp;Ying Liu ,&nbsp;Jiajun Wang ,&nbsp;Bo Lei ,&nbsp;Liang Tang ,&nbsp;Xianjuan Pu ,&nbsp;Minghong Wu","doi":"10.1016/j.envint.2025.109639","DOIUrl":"10.1016/j.envint.2025.109639","url":null,"abstract":"<div><div>The increasing demand and use of antibiotics due to epidemic outbreaks under climate change leads to more antibacterial substances entering the environment. The residual drugs, commonly found as mixtures, can specially target bacteria, posing a threat to the ecosystem and human health. Therefore, it is necessary to assess the risk of antibiotic mixtures using bacteria as the model organisms. In this study, selecting sulfonamides, sulfonamides potentiators, and tetracyclines as the representative antibiotics, the individual and combined toxicity of these agents were tested against Gram-positive (<em>Bacillus subtilis</em>) and Gram-negative bacteria (<em>Aliivibrio fischeri</em> and <em>Escherichia coli</em>). The quantitative structure–activity relationship models were constructed by setting E_bind (lowest interaction energy between antibiotic and target protein) and <em>K</em>_ow (octanol–water partition coefficient) as the structural descriptors, which provide reliable and robust tools for predicting the toxicity of single agents and binary mixtures. Furthermore, the hormetic effects, characterized by low-dose stimulation and high-dose inhibition, were observed in Gram-negative bacteria, and the dose-responses in Gram-positive bacteria all exhibited S-shaped. Within the hormetic phenomena of antibiotic mixtures, the pattern of joint toxic action and component contribution generally changed with the transition from stimulatory to inhibitory actions. These results not only demonstrate the influence of bacterial species and test endpoints on the toxicity of antibiotics, but also clarify the pivotal role of hormesis in the joint effects of antibiotics. This study provides a data-driven methodology for evaluating the combined toxicity of mixtures, which will promote the development of the risk assessment of antibiotics and other environmental pollutants.</div></div>","PeriodicalId":308,"journal":{"name":"Environment International","volume":"202 ","pages":"Article 109639"},"PeriodicalIF":10.3,"publicationDate":"2025-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144516279","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A machine learning approach to predict phyllosphere resistome abundance across urbanization gradients","authors":"Rui-Ao Ma ,&nbsp;Yi-Hui Ding ,&nbsp;Shifa Zhong ,&nbsp;Ting-Ting Jing ,&nbsp;Xuechu Chen ,&nbsp;Si-Yu Zhang","doi":"10.1016/j.envint.2025.109655","DOIUrl":"10.1016/j.envint.2025.109655","url":null,"abstract":"<div><div>Recent studies reported an increased abundance of antibiotic resistance genes (ARGs) in urban greenspaces, yet the predictability of ARG variance along urbanization gradients remains unclear. We sampled paired soil and phyllosphere samples from the same site in wetland parks along urbanization gradients to assess the correlations of soil and phyllosphere ARG abundance with urbanization indices. Our results revealed that the abundance of phyllosphere resistomes correlated better with urbanization gradients than did that of soil resistomes and increased along urbanization gradients. Moreover, the phyllosphere presented more ARG-MGE (mobile gene element) pairs in metagenome-assembled genomes than soil, suggesting greater transmission potential than soil ARGs. Proximity to the built area and microbial diversity were the most important factors that significantly (<em>p</em> &lt; 0.01) drove the variance in phyllosphere ARG abundance. By integrating population density, land use type, landscape metrics, and air quality data into machine learning models, we predicted phyllosphere ARG abundance at a 10-meter resolution. Among the five tested algorithms tested in the machine learning models (ridge regression, K-nearest neighbor, support vector machine, and neural network), the random forest algorithm achieved the highest accuracy with the lowest root mean square error (27.24 vs. 40.79–46.79 for the other models). These results demonstrate a strong association between phyllosphere ARG abundance and urbanization indices and provide predictions of the potential ARG risk along these gradients. The heightened transmission potential in urban greenspaces may facilitate the spread of antibiotic resistance spread to human pathogens, which poses significant public health threats.</div></div>","PeriodicalId":308,"journal":{"name":"Environment International","volume":"202 ","pages":"Article 109655"},"PeriodicalIF":10.3,"publicationDate":"2025-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144520863","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Per- and polyfluoroalkyl substances, genetic factors, and sleep health in reproductive-aged women: a cross-sectional study of the Shanghai Birth Cohort","authors":"Ruisi Wu ,&nbsp;Xiaoqing He ,&nbsp;Wen Jiang ,&nbsp;Azhu Han ,&nbsp;Ying Tian ,&nbsp;Jun Zhang ,&nbsp;Yun Huang ,&nbsp;for the Shanghai Birth Cohort","doi":"10.1016/j.envint.2025.109656","DOIUrl":"10.1016/j.envint.2025.109656","url":null,"abstract":"<div><div>Perfluoroalkyl and polyfluoroalkyl substances (PFAS) may exert neurotoxic effects and disrupt endocrine function. However, the relationship between PFAS exposure and sleep disturbances in reproductive-aged women, and its interaction with genetic susceptibility, remains unclear. This study included 971 women from the Shanghai Birth Cohort preconception cohort. A total of 22 PFAS were measured in plasma, and sleep quality was assessed using the Pittsburgh Sleep Quality Index. Modified Poisson regression and quantile g-computation models estimated the effects of individual PFAS and PFAS mixtures on sleep disturbances. Polygenic risk scores were used to evaluate the cumulative genetic effects of sleep disturbances. 6:2Cl-PFESA was associated with increased snoring and less daytime dysfunction, though these associations did not remain significant after FDR correction. Exposure to PFAS mixtures was significantly associated with an increased risk of snoring (RR: 2.02, 95 % CI: 1.06–3.83). Significant associations between PFNA, PFDA, branched PFOS isomers, and chlorinated PFOS alternatives and increased snoring risk were observed in women with a high genetic predisposition. PFAS exposures and genetic variants showed additive effects on snoring risk, with RERI of 1.19 for PFNA, 1.06 for PFDA, 4.18 for 8: 2Cl – PFESA, 0.43 for 6: 2Cl – PFESA, 5.96 for 3 m-PFOS, 11.11 for 1 m – PFOS, and 0.40 for n-PFOS. These findings suggest PFAS exposure, particularly emerging alternatives and isomers of PFOS, may increase snoring risk in reproductive-aged women with a higher genetic predisposition.</div></div>","PeriodicalId":308,"journal":{"name":"Environment International","volume":"202 ","pages":"Article 109656"},"PeriodicalIF":10.3,"publicationDate":"2025-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144520864","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}