Environment International最新文献

{"title":"Long-term green space exposure associated with lower mortality in prostate cancer survivors: a retrospective cohort study using SEER from 1995 to 2019","authors":"John S. Ji ,&nbsp;Haowen Wang ,&nbsp;Jialu Song ,&nbsp;Hari S. Iyer ,&nbsp;Mengyuan Xu ,&nbsp;Yishan Zhang ,&nbsp;Xavier Farre ,&nbsp;Hongmei Zeng ,&nbsp;Hao Ping","doi":"10.1016/j.envint.2025.109812","DOIUrl":"10.1016/j.envint.2025.109812","url":null,"abstract":"<div><div>Studies show green space is associated with lower prostate cancer incidence, but its effect on survival outcomes remains unclear. This study aims to assess whether green space improves prostate cancer survival outcomes. We examined the associations of green space with mortality in men with prostate cancer diagnosis. We conducted a retrospective cohort study using data from the Surveillance, Epidemiology, and End Results (SEER) database (1995–2019), covering 12.24 % of the U.S. population. Green space exposure was measured using annual averaged Normalized Difference Vegetation Index (NDVI). Associations between NDVI and mortality were evaluated using cause-specific Cox regression models, adjusting for demographic, clinical, socioeconomic, environmental, climate, and social capital factors. Effect modifications by race/ethnicity and surgery status were also examined. In this multi-state population-based study in the US, we found that long-term exposure to green spaces was associated with lower risks of prostate cancer specific mortality (3–5 years, HR = 0·74, 95 %CI [0.69–0.79]). NDVI has effect modification on race, with NDVI showing the strongest protective effect in Non-Hispanic Whites and Non-Hispanic Blacks. Higher NDVI reduced the negative impact of not undergoing surgery on prostate cancer-specific mortality (low NDVI: HR = 1.98, 95 % CI [1.87–2.11]; high NDVI: HR = 1.70, 95 % CI [1.59–1.82]). These findings emphasize the importance of creating better living environments for advanced-stage patients, highlighting the potential value of integrating green spaces in hospice and palliative care settings to enhance end-of-life care.</div></div>","PeriodicalId":308,"journal":{"name":"Environment International","volume":"204 ","pages":"Article 109812"},"PeriodicalIF":9.7,"publicationDate":"2025-09-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145127893","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Unfolding pesticide transport from land to rivers and the resulting aquatic risks in China","authors":"Bin Zhang ,&nbsp;Hongyu Mu ,&nbsp;Hua Li ,&nbsp;Xiaomei Yang ,&nbsp;Xianghua Zhang ,&nbsp;Runhui Ke ,&nbsp;Guang Yang ,&nbsp;Yanan Li ,&nbsp;Siqi Gao ,&nbsp;Yalan Zhou ,&nbsp;Wenxiu Chen ,&nbsp;Yan Yan ,&nbsp;Kai Wang ,&nbsp;Xuejun Liu ,&nbsp;Wei An ,&nbsp;Min Yang","doi":"10.1016/j.envint.2025.109803","DOIUrl":"10.1016/j.envint.2025.109803","url":null,"abstract":"<div><div>Pesticides have been widely applied in China, potentially leading to negative effects on the aquatic ecosystem. However, a national risk map of pesticide active ingredients (AIs) to aquatic species is still lacking. In this study, we used a nationwide spatially explicit pesticide input dataset to estimate the riverine concentrations of 133 AIs in China and further assessed the risks to aquatic species. Our analysis shows that pesticides were intensively applied in the North China Plain and the middle and lower reaches of the Yangtze River basin, with rice and maize received the highest shares of input at 42% and 21%, respectively. Under the current pesticide input patterns, in total 631 tons of pesticides, which is approximately 0.04% of applied pesticides, were transported into rivers through runoff. Atrazine showed the highest predicted concentrations in rivers, followed by propisochlor and nicosulfuron. Aquatic risks were found in 57% of river basins, with 5% and 13% of rivers exhibiting extremely high and high risks. Extremely high and high risk were found mainly in upper reaches of the Yangtze River, middle reaches of the Yellow River, and the Pearl River. Notably, endosulfan was the major contributor to aquatic risk, with an input only accounting for 0.4% of the national input mass. Our analysis facilitates more precise pesticide supervision and the designation of risk mitigation strategies.</div></div>","PeriodicalId":308,"journal":{"name":"Environment International","volume":"204 ","pages":"Article 109803"},"PeriodicalIF":9.7,"publicationDate":"2025-09-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145116757","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Unveiling biodegradation mechanism of phoxim: Novel metabolic pathway, functional gene, detoxification effect, and widespread distribution of phoA","authors":"Qian Li ,&nbsp;Mingliang Zhang ,&nbsp;Jiawen Zhu ,&nbsp;Hongfei Liu ,&nbsp;Gang Hu ,&nbsp;Junqiang Hu ,&nbsp;Kaihua Pan ,&nbsp;Jiandong Jiang ,&nbsp;Qing Hong","doi":"10.1016/j.envint.2025.109809","DOIUrl":"10.1016/j.envint.2025.109809","url":null,"abstract":"<div><div>Phoxim, an organophosphorus insecticide (OP), poses risks to non-target organisms in the environment. However, the biodegradation mechanism of phoxim was not fully understood. In this study, a novel detoxification pathway for phoxim in <em>Delftia lacustris</em> PX-1 was identified. A gene cluster <em>pho</em> (<em>phoABC1C2DEFGHI</em>), located on the plasmid, was found to be involved in phoxim degradation. The genes <em>phoA</em>, <em>phoB</em>, and <em>phoD</em>, which were responsible for converting phoxim to benzoate, were functionally characterized <em>in vitro</em>. Notably, PhoA was highly abundant in global cultivated lands. Moreover, acute toxicity experiments showed that both phoxim and its metabolite, 2-hydroxyimino-2-phenylacetonitrile (2H2P), exhibited moderate toxicity to zebrafish, whereas strain PX-1 could detoxify both compounds through degradation. After exposure to 2 mg L⁻¹ phoxim, the brain acetylcholinesterase (AChE) activity levels of zebrafish dramatically decreased by 31.28 % (<em>P</em> &lt; 0.05) relative to unexposed controls. Interestingly, phoxim could promote the colonization of strain PX-1 in the zebrafish gut, which mitigated phoxim-induced damage to AChE activity in the zebrafish brain. In summary, our research reveals a novel phoxim detoxification mechanism and provides a theoretical foundation for the bioremediation of residual phoxim in the environment.</div></div><div><h3>In brief</h3><div>This study reveals a novel metabolic pathway for phoxim biodegradation and elucidates the detoxification mechanism of strain PX-1 in zebrafish.</div></div>","PeriodicalId":308,"journal":{"name":"Environment International","volume":"204 ","pages":"Article 109809"},"PeriodicalIF":9.7,"publicationDate":"2025-09-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145116758","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluating wastewater surveillance for estimating pharmaceutical use","authors":"Gilbert Osena ,&nbsp;Jerker Fick ,&nbsp;Carl-Fredrik Flach ,&nbsp;Erik Kristiansson ,&nbsp;D.G. Joakim Larsson","doi":"10.1016/j.envint.2025.109807","DOIUrl":"10.1016/j.envint.2025.109807","url":null,"abstract":"<div><div>Regional medicine use data is key for health management and in understanding many aspects of health, still such data is missing in many parts of the world. Here, we aimed to evaluate how well analyses of active pharmaceutical ingredients (APIs) in untreated municipal wastewater could be used to predict regional use. We studied 53 APIs measured at three wastewater treatment plants (WWTPs) in Stockholm, Sweden between 2004–2021 together with corresponding, comprehensive sales data from hospitals, pharmacies and other outlets as proxy for use. Conversion factors (CFs) representing recovered mass per gram of sold API were generated for each API using data from two WWTPs. Median absolute deviation normalized by the median (MADM) was used to evaluate variability of CFs over the years. While CFs ranged more than two orders of magnitude between different APIs, mass loads recovered in wastewater were equal or less than the estimated daily use for all except one API. The variability of CF estimates was below 100 % for 43 APIs. When evaluating the predictive performance of the derived CFs on data from the third WWTP, the typical error was &lt;2-fold for 36 APIs (68 %). Further, our usage predictions aligned well for the majority of APIs when applied to data from independent international studies. Neither removal efficiency in WWTPs nor lipophilicity were good predictors of CFs. Our findings suggest that use of most APIs can be estimated from traces measured in wastewater with a typical error of &lt;2-fold. This provides support for the development of wastewater surveillance for estimating medicine use to fill existing data gaps, but also suggests limitations in detecting small changes.</div></div>","PeriodicalId":308,"journal":{"name":"Environment International","volume":"204 ","pages":"Article 109807"},"PeriodicalIF":9.7,"publicationDate":"2025-09-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145116756","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Long-term exposure to ultrafine particles and its association with cardiometabolic diseases, chronic obstructive pulmonary disease, and cardiometabolic biomarkers: A cross-sectional analysis of the German National cohort (NAKO)","authors":"Susanne Breitner-Busch ,&nbsp;Kathrin Wolf ,&nbsp;Josef Cyrys ,&nbsp;Alexandra Schneider ,&nbsp;Regina Pickford ,&nbsp;Marco Dallavalle ,&nbsp;Susanne Sues ,&nbsp;Beate Fischer ,&nbsp;Michael Leitzmann ,&nbsp;Jens Soentgen ,&nbsp;Annette Peters","doi":"10.1016/j.envint.2025.109806","DOIUrl":"10.1016/j.envint.2025.109806","url":null,"abstract":"<div><div>There is limited epidemiological evidence regarding the health effects of ultrafine particles (UFP; particles with an aerodynamic diameter of 10–100 nm). This study investigated whether long-term exposure to total particle number concentration (PNC), used as a surrogate for UFP, is associated with cardiometabolic diseases, chronic obstructive pulmonary disease (COPD), and cardiometabolic biomarkers.</div><div>Our cross-sectional study included 27,390 participants of the NAKO study centers in Augsburg and Regensburg in Southern Germany. Health outcomes included self-reported, physician-diagnosed diseases such as hypertension, myocardial infarction, or COPD, alongside blood biomarkers such as glucose. Annual PNC averages for 2014 were estimated using supervised land use regression models and linked to participants’ home addresses. We also obtained annual averages of further pollutants (e.g., particulate matter ≤ 2.5 µm (PM_2.5)) for 2010. We applied covariate-adjusted logistic and linear regression models to examine associations between PNC and health outcomes. Additionally, we assessed interdependencies between pollutants using two-pollutant models.</div><div>Long-term exposure to PNC was associated with increased odds of hypertension and myocardial infarction, and COPD, as well as elevated glucose and leukocyte levels. For example, the odds ratio for hypertension was 1.03 (95% confidence interval: 1.01;1.05) for each increase in PNC by 1000 particles/cm³. Two-pollutant models did not substantially change the results for PNC but led to slightly wider confidence intervals.</div><div>In conclusion, our study suggests that long-term exposure to PNC, as a surrogate for UFP, contributes to the risk of hypertension, myocardial infarction, COPD, and elevated blood glucose and leukocyte levels in adults. These results highlight the role of UFP within the broader mixture of ambient air pollution and underscore the need for strategies to reduce UFP exposure to prevent adverse cardiometabolic and pulmonary health effects.</div></div>","PeriodicalId":308,"journal":{"name":"Environment International","volume":"204 ","pages":"Article 109806"},"PeriodicalIF":9.7,"publicationDate":"2025-09-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145089273","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"From screening to risk assessment: a comparative study on product usage, human burden, and potential neurotoxicity of novel paraben analogues","authors":"Lingxue Meng ,&nbsp;Hongxuan Kuang ,&nbsp;Jianhua Tan ,&nbsp;Xinling Li ,&nbsp;Ye Liu ,&nbsp;Mingdeng Xiang ,&nbsp;Yang Zhou ,&nbsp;Ruifang Fan ,&nbsp;Yunjiang Yu","doi":"10.1016/j.envint.2025.109805","DOIUrl":"10.1016/j.envint.2025.109805","url":null,"abstract":"<div><div>Parabens are extensively used preservatives with endocrine disrupting effects and neurotoxicity. Their restricted usage may drive the development of alternatives for producing preservative-free products. Nevertheless, the prevalence and health risks of paraben analogues remain poorly understood. Herein, we screened potential paraben analogues using high-resolution mass spectrometry and assessed their prevalence in personal care products (PCPs) and population exposure trends. We first identified p-hydroxyacetophenone (PhAc), a structural analogue of parabens, in children’s urine based on the common fragmentation characteristics of parabens. Quantitative analysis revealed that the average content of PhAc in PCPs was 2–38 times higher than that of typical parabens. Furthermore, the longitudinal biomonitoring study conducted from 2016 to 2023 revealed that the geometric mean levels of PhAc in the urine of children aged 5–13 years in South China increase from 35.20 μg/L to 102.68 μg/L, which is 1–3 orders of magnitude greater than parabens. Nevertheless, PhAc is not a permitted preservative in PCPs and its health risk is unclear. To investigate the potential neurotoxicity of extensively present PhAc, neuronal cells were exposed to different concentrations of PhAc and typical parabens for 24 h, respectively. The results indicated that PhAc exhibited greater potential neurotoxicity than methylparaben, the most widely used paraben. Even exposure to doses comparable to urinary PhAc concentrations (100 nM-1 μM) could significantly disrupt metabolism homeostasis, damage cell membranes and morphology, and increase apoptosis rate in neuronal cells. Therefore, PhAc, a new paraben analogue with wider product applications, higher human exposure, and greater potential neurotoxicity, may pose considerable ecological and human health risks.</div></div>","PeriodicalId":308,"journal":{"name":"Environment International","volume":"204 ","pages":"Article 109805"},"PeriodicalIF":9.7,"publicationDate":"2025-09-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145093710","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Melamine and its derivatives in Australian pooled urine samples from 2012–2013 and 2022–2023","authors":"Yarui Liu ,&nbsp;Pritesh Prasad ,&nbsp;Danielle E. Que ,&nbsp;Geoff Eaglesham ,&nbsp;Yuya Cheng ,&nbsp;Peter Hobson ,&nbsp;Heath Glover ,&nbsp;Hongkai Zhu ,&nbsp;Shuo Wang ,&nbsp;Leisa-Maree Toms ,&nbsp;Jochen F. Mueller","doi":"10.1016/j.envint.2025.109804","DOIUrl":"10.1016/j.envint.2025.109804","url":null,"abstract":"<div><div>Melamine is a versatile compound with various industrial and commercial applications, and the long-term use has resulted in its widespread occurrence in the environment. Furthermore, illicit addition of melamine into food products has raised interest in this compound. The aim of this study was to provide the first assessment of exposure to melamine and its derivatives in the Australian population. De-identified urine specimens collected in 2012–2013 and 2022–2023 were obtained from a community-based pathology laboratory and were pooled based on sex and age groups (n = 48 pools of 100, to a total of 4800 individual samples). Melamine, cyanuric acid (CYA), and ammelide were frequently detected in the pooled urine samples, with mean concentrations of 4.3, 94, and 4.2 ng/mL, respectively. A U-shaped trend in urinary concentrations of melamine was identified as age increased. Children and adolescents (&lt; 15 years old) represented key groups for high exposure to CYA, whereas older individuals (≥45 years old) had higher exposure risk to ammelide. No temporal or sex differences was observed in urinary concentrations of melamine and its derivatives. Compared to other countries, high concentrations of CYA were observed in samples collected from the Australian population. From the estimated CYA daily intakes, 21 % of urine pools exceeded reference doses (2.5 μg/kg bw/day). To the best of our knowledge, this is the first study to reveal continued exposure of melamine and its derivatives in the Australian population and underscore the age trends of their urinary concentrations.</div></div>","PeriodicalId":308,"journal":{"name":"Environment International","volume":"204 ","pages":"Article 109804"},"PeriodicalIF":9.7,"publicationDate":"2025-09-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145089274","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Unraveling the impact of prenatal air pollution for neonatal brain maturation","authors":"Jesus Pujol ,&nbsp;Gerard Martínez-Vilavella ,&nbsp;Laura Gómez-Herrera ,&nbsp;Ioar Rivas ,&nbsp;Maria Dolors Gómez-Roig ,&nbsp;Elisa Llurba ,&nbsp;Laura Blanco-Hinojo ,&nbsp;Marta Cirach ,&nbsp;Cecilia Persavento ,&nbsp;Xavier Querol ,&nbsp;Mireia Gascón ,&nbsp;Maria Foraster ,&nbsp;Juan Domingo Gispert ,&nbsp;Carles Falcón ,&nbsp;Joan Deus ,&nbsp;Payam Dadvand ,&nbsp;Jordi Sunyer","doi":"10.1016/j.envint.2025.109801","DOIUrl":"10.1016/j.envint.2025.109801","url":null,"abstract":"<div><div>Early brain development is highly sensitive to environmental influences. While prenatal exposure to airborne particulate matter (PM_2.5) has been broadly associated with harmful effects, PM_2.5 also contains trace elements such as iron, copper and zinc, which are essential for brain growth. This study examined both the overall impact of prenatal PM_2.5 exposure and the specific role of these trace elements on neonatal myelinated white matter—a key marker of brain maturation. This population-based study included 93 neonates recruited from three major hospitals in Barcelona (2018–2021). PM_2.5 exposure was estimated for the embryonic and late fetal periods using land-use regression models incorporating time-weighted maternal mobility data. MRI was performed at 29 days postnatally. Global myelinated white matter was manually segmented, and automated cortical myelination measures were obtained in 85 cases. Associations were examined using linear regression models with and without adjustment for potential confounders. Higher prenatal PM_2.5 exposure was associated with lower myelinated white matter content. Trace elements showed a similar pattern, but their associations became nonsignificant after adjusting for overall PM_2.5 exposure. The findings suggest that prenatal air pollution exposure may delay early myelination. Moreover, no specific associations were identified for iron, copper, or zinc. However, given the dynamic nature of white matter maturation, such delays may not necessarily be detrimental. This study underscores the impact of environmental factors on neonatal brain development and the importance of stringent air quality policies, while emphasizing the need for longitudinal research to assess long-term cognitive and behavioral outcomes.</div></div>","PeriodicalId":308,"journal":{"name":"Environment International","volume":"204 ","pages":"Article 109801"},"PeriodicalIF":9.7,"publicationDate":"2025-09-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145084372","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ozone and PM2.5 co-exposure induced neurodegenerative alterations in mice: Implication of mitochondrial dysfunction in glial cells","authors":"Lin Yang ,&nbsp;Shuaiqi Zhao ,&nbsp;Qiong Wu ,&nbsp;Yuling Zeng ,&nbsp;Aogang Zhang ,&nbsp;Han Sun ,&nbsp;Fei Xu ,&nbsp;Saige Shi ,&nbsp;Juan Li ,&nbsp;Zhen An ,&nbsp;Huijun Li ,&nbsp;Hui Wu ,&nbsp;Laibao Zhuo ,&nbsp;Jie Song ,&nbsp;Wen Chen ,&nbsp;Weidong Wu","doi":"10.1016/j.envint.2025.109802","DOIUrl":"10.1016/j.envint.2025.109802","url":null,"abstract":"<div><div>Co-occurrence of ground-level ozone (O₃) and fine particulate matter (PM_2.5, ≤2.5 μm in aerodynamic diameter) has been a common air pollution scenario in urban areas worldwide. Existing evidence indicates exposure to O₃ or PM_2.5 is associated with neurodegenerative alterations. However, the association of co-exposure to O₃ and PM_2.5 with neurodegenerative disorders has been scarcely reported. This study examined neurodegenerative alterations following O₃ and PM_2.5 co-exposure and potential mechanisms. Ten-month-old male C57BL/6 mice were randomly divided into four groups: control, O₃, PM_2.5, and co-exposure (O₃ + PM_2.5). The conditions of co-exposure were established based on a real environmental exposure in the Central Plains Urban Agglomeration in Central China. Specifically, O₃ exposure was set at 0.6 ppm for 4 h/day over 30 consecutive days, while PM_2.5 exposure was performed through oropharyngeal aspiration of PM_2.5 suspension (5.6 mg/kg bw) every other day, 4 h prior to O₃ exposure. The results demonstrated that co-exposure significantly worsened memory impairment, neuroinflammation, blood–brain barrier (BBB) damage, and activation of glial cells, indicative of neurodegeneration. Omics approaches further revealed oxidative stress, mitochondrial injury, and endoplasmic reticulum stress in glial clusters following co-exposure. Moreover, strong associations between memory impairment, neuroinflammation, glial cell activation, and brain tissue damage with mitochondrial complex dysfunction in glial cells were uncovered. Taken together, O₃ and PM_2.5 co-exposure exacerbates neurodegenerative disorders, which involves mitochondrial complex dysfunction in glial cells, especially astrocytes. This study provides insights into the mechanisms underlying air pollution-induced neurodegenerative diseases.</div></div>","PeriodicalId":308,"journal":{"name":"Environment International","volume":"204 ","pages":"Article 109802"},"PeriodicalIF":9.7,"publicationDate":"2025-09-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145084370","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Neighborhood green space and psychological distress: a longitudinal study of socioeconomic disparities in mental health outcomes","authors":"Cedric Galera ,&nbsp;Marie C Navarro ,&nbsp;Charline Galesne ,&nbsp;Noelia Retuerto ,&nbsp;Francesca Bentivegna ,&nbsp;Eirini Flouri","doi":"10.1016/j.envint.2025.109799","DOIUrl":"10.1016/j.envint.2025.109799","url":null,"abstract":"<div><div>Evidence suggests that neighborhood green space is associated with improvements in mental health. However, few studies have simultaneously considered both the risky and protective dimensions of green space in relation to psychological distress. Moreover, whether these spaces contribute to narrowing gaps in mental health problems across different social groups remains insufficiently understood. We aimed to examine the longitudinal association between neighborhood green space and psychological distress in adults, taking into account socioeconomic disparities.</div><div>We used data from the Millennium Cohort Study (25,442 adult participants from the UK, 2003 to 2016) and applied mixed-effects models to assess the average longitudinal association between neighborhood green space exposure (measured as relative green space cover in deciles, comparing the highest and lowest deciles to the eight middle deciles) and psychological distress, adjusting for socioeconomic variables (poverty, education, ethnicity) and other potential confounders (age, sex, urbanicity, physical health, air pollution). Low green space exposure was associated with higher psychological distress. High green space exposure was consistently associated with lower psychological distress among socioeconomically disadvantaged individuals, with more robust and pronounced effects compared to wealthier groups. Overall, the lack of neighborhood green space may be more influential on psychological distress than its abundance, except for the most disadvantaged adults, for whom a high level of green space could be particularly beneficial. Fostering access to neighborhood green space may serve as a valuable strategy to reduce both environmental and mental health disparities.</div></div>","PeriodicalId":308,"journal":{"name":"Environment International","volume":"204 ","pages":"Article 109799"},"PeriodicalIF":9.7,"publicationDate":"2025-09-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145077661","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}