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Prenatal and childhood exposure to mixtures of endocrine-disrupting chemicals in association with measures of adiposity in childhood and adolescence 产前和儿童时期接触内分泌干扰化学物质的混合物与儿童和青少年肥胖的测量有关
IF 10.2 1区 环境科学与生态学
Environment International Pub Date : 2026-09-01 Epub Date: 2026-09-03 DOI: 10.1016/j.envint.2026.110495
Nuria Güil-Oumrait, Vishal Midya, Sandra India-Aldana, Augusto Anguita-Ruiz, Léa Maitre, Mariona Bustamante, Parisa Montazeri, Jose Urquiza, Line Småstuen Haug, Anne Lise Brantsæter, Barbara Heude, John Wright, Tiffany C. Yang, Rosemary R.C. McEachan, Euripides G. Stephanou, Regina Grazuleviciene, Rémy Slama, Leda Chatzi, Martine Vrijheid, Damaskini Valvi
{"title":"Prenatal and childhood exposure to mixtures of endocrine-disrupting chemicals in association with measures of adiposity in childhood and adolescence","authors":"Nuria Güil-Oumrait,&nbsp;Vishal Midya,&nbsp;Sandra India-Aldana,&nbsp;Augusto Anguita-Ruiz,&nbsp;Léa Maitre,&nbsp;Mariona Bustamante,&nbsp;Parisa Montazeri,&nbsp;Jose Urquiza,&nbsp;Line Småstuen Haug,&nbsp;Anne Lise Brantsæter,&nbsp;Barbara Heude,&nbsp;John Wright,&nbsp;Tiffany C. Yang,&nbsp;Rosemary R.C. McEachan,&nbsp;Euripides G. Stephanou,&nbsp;Regina Grazuleviciene,&nbsp;Rémy Slama,&nbsp;Leda Chatzi,&nbsp;Martine Vrijheid,&nbsp;Damaskini Valvi","doi":"10.1016/j.envint.2026.110495","DOIUrl":"10.1016/j.envint.2026.110495","url":null,"abstract":"<div><h3>Background</h3><div>Childhood obesity is a global public health crisis. Endocrine-disrupting chemicals (EDCs) − widespread pollutants that interfere with hormonal and metabolic systems − may contribute to excessive adiposity. The combined, long-term, and mechanistic effects of multi-class EDC mixtures remain unexplored.</div></div><div><h3>Methods</h3><div>We analyzed 1301 mother–child pairs from the Human Early Life Exposome (HELIX) project, spanning six European cohorts. Prenatal and childhood exposures to 45 EDCs across nine chemical classes were measured in maternal and child biospecimens. Thirty-six plasma proteins were quantified in childhood using targeted proteomic panels. Adiposity outcomes in childhood (6–11 years) and adolescence (12–18 years) included BMI z-scores, waist circumference, and body fat percentage. We applied penalized Lasso-type Bayesian Weighted Quantile Sum Regression to assess mixtures, a signed iterative random forest for interactions, and mediation analyses for biological pathways.</div></div><div><h3>Results</h3><div>Prenatal metal and organochlorine pesticide mixtures were associated with higher BMI z-scores in childhood and adolescence and 47–48 % higher odds of overweight. Prenatal PFAS exposure was associated with higher body-fat percentage in both periods. Childhood phenol and high-molecular-weight phthalate exposures were associated with higher adolescent zBMI, whereas parabens and persistent compounds showed inverse associations. Childhood metal exposures were associated with higher body-fat percentage and overweight odds. An inflammatory-metabolic protein pattern mediated ∼ 30 % of the prenatal metal-adolescent zBMI association.</div></div><div><h3>Conclusions</h3><div>Early-life exposure to EDC mixtures may reprogram metabolic and inflammatory pathways, predisposing children to obesity that persists into adolescence. These findings provide mechanistic evidence linking chemical exposures to the global obesity epidemic and underscore the urgent need for policies preventing EDC exposure during critical developmental periods.</div></div>","PeriodicalId":308,"journal":{"name":"Environment International","volume":"215 ","pages":"Article 110495"},"PeriodicalIF":10.2,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148895550","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Corrigendum to “Effects of ambient fine particulates, nitrogen dioxide, and ozone on maturation of functional brain networks across early adolescence” [Environ. Int. 177 (2023) 108001] “环境细颗粒物、二氧化氮和臭氧对青春期早期大脑功能网络成熟的影响”的更正[环境]。Int. 177(2023) 108001]。
IF 10.2 1区 环境科学与生态学
Environment International Pub Date : 2026-09-01 Epub Date: 2026-07-30 DOI: 10.1016/j.envint.2026.110417
Devyn L. Cotter, Claire E. Campbell, Kirthana Sukumaran, Rob McConnell, Kiros Berhane, Joel Schwartz, Daniel A. Hackman, Hedyeh Ahmadi, Jiu-Chiuan Chen, Megan M. Herting
{"title":"Corrigendum to “Effects of ambient fine particulates, nitrogen dioxide, and ozone on maturation of functional brain networks across early adolescence” [Environ. Int. 177 (2023) 108001]","authors":"Devyn L. Cotter,&nbsp;Claire E. Campbell,&nbsp;Kirthana Sukumaran,&nbsp;Rob McConnell,&nbsp;Kiros Berhane,&nbsp;Joel Schwartz,&nbsp;Daniel A. Hackman,&nbsp;Hedyeh Ahmadi,&nbsp;Jiu-Chiuan Chen,&nbsp;Megan M. Herting","doi":"10.1016/j.envint.2026.110417","DOIUrl":"10.1016/j.envint.2026.110417","url":null,"abstract":"","PeriodicalId":308,"journal":{"name":"Environment International","volume":"215 ","pages":"Article 110417"},"PeriodicalIF":10.2,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148629183","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Nitrogen-containing organic compounds in household solid-fuel combustion PM and residential urinary inflammatory and targeted amino-acid profiles: an exploratory personal exposure study 家用固体燃料燃烧PM中的含氮有机化合物和住宅泌尿炎性和靶向氨基酸谱:一项探索性个人暴露研究。
IF 10.2 1区 环境科学与生态学
Environment International Pub Date : 2026-09-01 Epub Date: 2026-08-30 DOI: 10.1016/j.envint.2026.110491
Yunxuan Gu, Hongmei Xu, Sulin Chen, Yuqi Pang, Bei Han, Lu Bai, Steven Sai Hang Ho, Jian Sun, Zhenxing Shen, Junji Cao
{"title":"Nitrogen-containing organic compounds in household solid-fuel combustion PM and residential urinary inflammatory and targeted amino-acid profiles: an exploratory personal exposure study","authors":"Yunxuan Gu,&nbsp;Hongmei Xu,&nbsp;Sulin Chen,&nbsp;Yuqi Pang,&nbsp;Bei Han,&nbsp;Lu Bai,&nbsp;Steven Sai Hang Ho,&nbsp;Jian Sun,&nbsp;Zhenxing Shen,&nbsp;Junji Cao","doi":"10.1016/j.envint.2026.110491","DOIUrl":"10.1016/j.envint.2026.110491","url":null,"abstract":"<div><div>Nitrogen-containing organic compounds (NOCs) are important constituents of fine particulate matter emitted from household solid-fuel combustion, yet their personal-exposure characteristics and potential biological relevance remain insufficiently understood. We conducted an exploratory cross-sectional study among 15 rural homemakers, including 12 solid-fuel users and three electric-heating controls. Personal breathing-zone PM<sub>2.5</sub> and PM<sub>0.25</sub> samples were collected during two consecutive 24-h periods, and six classes of filter-collected PM-associated NOCs were quantified. Urinary inflammatory and oxidative-stress-related biomarkers and a targeted panel of 62 amino-acid-related metabolites were also analyzed. Personal exposure concentrations of the measured NOC classes were substantially higher in solid-fuel households than in electric-heating households, with particularly pronounced differences in free amino acids (FAAs) and C6-C20 alkyl nitriles. Urea dominated the total measured NOC mass, whereas FAAs constituted the largest non-urea fraction in the solid-fuel group. Correlation and exploratory mixture-response analyses indicated that FAAs and alkyl nitriles were the NOC classes most consistently associated with urinary C-reactive protein and vascular endothelial growth factor. Targeted urinary amino-acid profiling identified lower urinary concentrations of 4-hydroxyphenyllactic acid and methylguanidine in solid-fuel users based on nominal criteria, together with a borderline reduction in serotonin. Exploratory KEGG analysis further organized the measured metabolites into broad amino-acid-related biochemical categories, but was not interpreted as evidence of pathway activation or impairment. Overall, household solid-fuel use was associated with an NOC-rich personal PM exposure profile and selected urinary biomarker and targeted amino-acid-related patterns. Given the small and imbalanced sample and cross-sectional design, these findings should be interpreted as hypothesis-generating associations rather than confirmed biomarkers, causal effects, or mechanistic evidence.</div></div>","PeriodicalId":308,"journal":{"name":"Environment International","volume":"215 ","pages":"Article 110491"},"PeriodicalIF":10.2,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148878589","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
PFAS disrupt adult hippocampal neurogenesis and synaptic remodeling associated with NOX2/ROS/Ferroptosis activation PFAS破坏与NOX2/ROS/Ferroptosis激活相关的成人海马神经发生和突触重塑
IF 10.2 1区 环境科学与生态学
Environment International Pub Date : 2026-09-01 DOI: 10.1016/j.envint.2026.110503
Xingcheng Li, Xiao Li, Cimei Li, Lingfen Cao, Siteng Li, Xiaoping Wang, Kangchao Du, Yaoyao Cui, Yuxiang Ma, Xu Wang, Xing Xing, Huigen Feng, Ciqing Yang, Xianwei Wang, Cixia Li
{"title":"PFAS disrupt adult hippocampal neurogenesis and synaptic remodeling associated with NOX2/ROS/Ferroptosis activation","authors":"Xingcheng Li,&nbsp;Xiao Li,&nbsp;Cimei Li,&nbsp;Lingfen Cao,&nbsp;Siteng Li,&nbsp;Xiaoping Wang,&nbsp;Kangchao Du,&nbsp;Yaoyao Cui,&nbsp;Yuxiang Ma,&nbsp;Xu Wang,&nbsp;Xing Xing,&nbsp;Huigen Feng,&nbsp;Ciqing Yang,&nbsp;Xianwei Wang,&nbsp;Cixia Li","doi":"10.1016/j.envint.2026.110503","DOIUrl":"10.1016/j.envint.2026.110503","url":null,"abstract":"<div><div>Per- and polyfluoroalkyl substances (PFAS) accumulate in the hippocampus, yet their effects on adult hippocampal neurogenesis (AHN) remain unclear. In this study, adult male mice were orally exposed to PFOA or GenX (2 or 10 mg/kg/day) for 28 days. Behavioral performance, AHN, synaptic remodeling, microglial morphology, and redox status were evaluated using behavioral assays, Nissl and Golgi staining, BrdU immunolabeling, microglial morphometric analyses, and Western blotting. PFOA exposure and high-dose GenX exposure reduced time spent and distance traveled in the center area of the open field and impaired spatial learning and memory performance in the Morris water maze, as indicated by increased escape latency and fewer platform crossings. In contrast, PFOA and low-dose GenX exposure reduced exploration of the open arms in the elevated plus maze. PFOA and GenX reduced dendritic spine density with fewer mushroom/thin spines and more stubby spines. PFOA preferentially decreased PSD95 (postsynaptic marker), whereas GenX reduced synaptophysin (presynaptic marker). In the subgranular zone (SGZ), survival and neuronal differentiation of neural stem cells were diminished, and asymmetric divisions of radial glia-like cells increased, suggesting stem-cell pool depletion. Microglia exhibited a hyper-ramified/bushy reactive phenotype. Hippocampal ROS/MDA rose, NOX2 components (GP91<sup>phox</sup>/P22<sup>phox</sup>) were upregulated, and ferroptosis defenses (SLC7A11/GLS2/GPX4) were downregulated. Collectively, PFOA and GenX disrupt hippocampal synaptic remodeling and AHN and are associated with increased oxidative stress and ferroptosis-related alterations. Differential pre- versus postsynaptic vulnerabilities may contribute to the distinct behavioral alterations observed following PFOA and GenX exposure. This work provides new insights into the neurotoxic effects of PFOA and GenX and identifies potential pathways involved in PFAS-induced hippocampal dysfunction.</div></div>","PeriodicalId":308,"journal":{"name":"Environment International","volume":"215 ","pages":"Article 110503"},"PeriodicalIF":10.2,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148883919","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
How routine fragrance product use elevates indoor PM2.5 exposure in London households 日常使用香氛产品如何提高伦敦家庭室内PM2.5暴露量。
IF 10.2 1区 环境科学与生态学
Environment International Pub Date : 2026-09-01 Epub Date: 2026-08-19 DOI: 10.1016/j.envint.2026.110471
Fei Gao, Tuan Vu, Michael Hedges, Sani Dimitroulopoulou, David Green, Adam Skillern, Benjamin Barratt, Diana Varaden, Frank J. Kelly, Sean Beevers
{"title":"How routine fragrance product use elevates indoor PM2.5 exposure in London households","authors":"Fei Gao,&nbsp;Tuan Vu,&nbsp;Michael Hedges,&nbsp;Sani Dimitroulopoulou,&nbsp;David Green,&nbsp;Adam Skillern,&nbsp;Benjamin Barratt,&nbsp;Diana Varaden,&nbsp;Frank J. Kelly,&nbsp;Sean Beevers","doi":"10.1016/j.envint.2026.110471","DOIUrl":"10.1016/j.envint.2026.110471","url":null,"abstract":"<div><div>Fragrance products are ubiquitous in UK homes, yet the associated indoor<!--> <!-->PM<sub>2.5</sub> exposure remains poorly quantified under real residential conditions. Using high time-resolution measurements from 112 London homes between 2022 and 2024, together with a source-resolved framework, our study found that fragrance use markedly elevated indoor PM<sub>2.5</sub> exposure, with hourly peaks up to 1293 μg/m<sup>3</sup> for incense, 858 μg/m<sup>3</sup> for oil diffusers, and 622 μg/m<sup>3</sup> for candles. Across homes using those fragrance products, incense and oil diffusers each accounted for nearly 50 % of bedroom PM<sub>2.5</sub> exposure, whereas candles contributed 14 %.<!--> <!-->Exceedance of the WHO 24-h<!--> <!-->guideline (15 μg/m<sup>3</sup>) was frequent, with a median exceedance rate of 40 %<!--> <!-->in candle-using homes, and in some incense–using households, exceedances occurring on the majority of monitored days. Exposures were highest in compact dwellings and under inadequate room ventilation. As UK housing moves toward greater airtightness, these findings identify fragrance products as a dominant indoor PM<sub>2.5</sub> source and provide empirical evidence relevant to source–aware ventilation design and Net Zero housing assessments.</div></div>","PeriodicalId":308,"journal":{"name":"Environment International","volume":"215 ","pages":"Article 110471"},"PeriodicalIF":10.2,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148885854","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Prenatal and early life phthalate exposure and early life stress: no interactions with adolescent internalizing symptoms 产前和生命早期邻苯二甲酸盐暴露和生命早期压力:与青少年内化症状无相互作用。
IF 10.2 1区 环境科学与生态学
Environment International Pub Date : 2026-09-01 Epub Date: 2026-09-02 DOI: 10.1016/j.envint.2026.110500
Mariah DeSerisy, Gabriella Meltzer, Arin Balalian, Shabnaz Siddiq, Autumn M Clemons, Julie B. Herbstman, Virginia A. Rauh, Frederica P. Perera, Amy E. Margolis, Pam Factor-Litvak
{"title":"Prenatal and early life phthalate exposure and early life stress: no interactions with adolescent internalizing symptoms","authors":"Mariah DeSerisy,&nbsp;Gabriella Meltzer,&nbsp;Arin Balalian,&nbsp;Shabnaz Siddiq,&nbsp;Autumn M Clemons,&nbsp;Julie B. Herbstman,&nbsp;Virginia A. Rauh,&nbsp;Frederica P. Perera,&nbsp;Amy E. Margolis,&nbsp;Pam Factor-Litvak","doi":"10.1016/j.envint.2026.110500","DOIUrl":"10.1016/j.envint.2026.110500","url":null,"abstract":"<div><div>Prenatal and early life exposure to phthalates has been increasingly implicated in adverse neurodevelopmental outcomes. However, associations between phthalate exposure in early life and later adolescent mental health remain understudied, particularly when also considering co-exposure to early life psychosocial stressors. We examined the independent and combined associations of prenatal and early life (ages three, five, and seven) phthalate exposure with adolescent internalizing symptoms in a longitudinal cohort of 563 Black and Latiné mother–child dyads living in a low-income urban neighborhood. We further explored whether early life stress modified these associations or predicted internalizing symptoms independently. Exposure to eleven common phthalates was assessed using urinary metabolites measured in the third trimester of pregnancy and in children ages three, five, and seven. Early life stress was operationalized by a composite measure of material hardship and maternal demoralization measured concurrently with phthalate exposure. Youth self-reported anxiety and depression symptoms were measured between ages 13–15 with the Revised Children’s Manifest Anxiety Scale and Center for Epidemiological Studies Depression Inventory, respectively. Bayesian kernel machine regression assessed effects of the phthalate mixture on anxiety and depression symptoms. False discovery rate-corrected, pooled linear regressions tested individual phthalate effects, stratified by sex, and tested early life stress as an effect modifier. We did not detect significant associations between prenatal or postnatal phthalate exposure—either independently or jointly—and adolescent depression or anxiety; early life stress did not modify these associations or independently predict symptomology. However, uncertainty in effect estimates necessitates future research to clarify if these null effects hold in larger samples. If replicated, our findings suggest that there may be important, as yet unknown resilience factors protecting youth from long term effects of early phthalate exposure.</div></div>","PeriodicalId":308,"journal":{"name":"Environment International","volume":"215 ","pages":"Article 110500"},"PeriodicalIF":10.2,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148885889","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Assessing intergenerational health equity in the mortality impacts of acute and chronic air pollution exposure 评估急性和慢性空气污染暴露对死亡率影响的代际健康公平。
IF 10.2 1区 环境科学与生态学
Environment International Pub Date : 2026-09-01 Epub Date: 2026-09-08 DOI: 10.1016/j.envint.2026.110515
Lei Yuan, Aurelio Tobias, Yasushi Honda, Chris Fook Sheng Ng, Hironori Nishikawa, Lina Madaniyazi, Kayo Ueda, Masahiro Hashizume
{"title":"Assessing intergenerational health equity in the mortality impacts of acute and chronic air pollution exposure","authors":"Lei Yuan,&nbsp;Aurelio Tobias,&nbsp;Yasushi Honda,&nbsp;Chris Fook Sheng Ng,&nbsp;Hironori Nishikawa,&nbsp;Lina Madaniyazi,&nbsp;Kayo Ueda,&nbsp;Masahiro Hashizume","doi":"10.1016/j.envint.2026.110515","DOIUrl":"10.1016/j.envint.2026.110515","url":null,"abstract":"<div><h3>Background</h3><div>Although mortality effects of short- and long-term air pollution exposure have been widely studied, temporal and intergenerational variations in vulnerability across age and cause-specific groups remain unclear.</div></div><div><h3>Methods</h3><div>We analyzed over 3.2 million individual death records from the ten most populated Japanese cities (1977–2015), constructing 5-year birth cohorts for middle-aged (40–64 years) and elder adults (65–89 years). Using a space–time–stratified case-crossover design for acute effects and an adapted difference-in-difference approach for chronic effects, we estimated cause-specific mortality risks per 10 unit increase in suspended particulate matter (SPM), nitrogen dioxide (NO<sub>2</sub>), sulfur dioxide (SO<sub>2</sub>), and photochemical oxidant (O<sub>x</sub>). Intergenerational trends were assessed using weighted linear regression of log-transformed relative risks (RRs) on birth cohort.</div></div><div><h3>Results</h3><div>SPM, NO<sub>2</sub>, and SO<sub>2</sub> declined across cohorts, while O<sub>x</sub> exhibited a gradual increase. We found higher short-term SPM-related mortality risks among middle-aged and elder adults born in more recent generations (all-cause mortality, middle-aged adults: RR<sub>1931-1935</sub> = 1.0011, 95% CI: 0.9985–1.0036 to RR<sub>1951-1955</sub> = 1.0097, 95% CI: 1.0047–1.0147; elder adults: RR<sub>1906-1910</sub> = 1.0025, 95% CI: 1.0008–1.0042 to RR<sub>1926-1930</sub> = 1.0055, 95% CI: 1.0034–1.0076). Middle-aged adults from younger generations were more sensitive to both acute and chronic NO<sub>2</sub> effects on all-cause and non-external mortality, whereas elder adults born in younger generations showed increased susceptibility to short-term and long-term O<sub>x</sub>-related mortality for respiratory and circulatory causes, respectively. We also observed intergenerational increases in the acute effects of SO<sub>2</sub> on mortality among elder adults. Chronic effects showed cohort-specific variations, whereas acute effects were generally consistent.</div></div><div><h3>Discussion</h3><div>Our cohort-based analysis provides the first direct evidence of intergenerational differences in both acute and chronic mortality effects of multiple air pollutants. These findings highlight intergenerational inequities in susceptibility to air pollution and the importance of considering such differences in future health impact assessments.</div></div>","PeriodicalId":308,"journal":{"name":"Environment International","volume":"215 ","pages":"Article 110515"},"PeriodicalIF":10.2,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148928468","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Analysis of ultra short-chain PFAS in urine: method development by LC-MS/MS and first human biomonitoring results from the German National Cohort (NAKO) 尿液中超短链PFAS的分析:LC-MS/MS方法开发和来自德国国家队列(NAKO)的首次人体生物监测结果
IF 10.2 1区 环境科学与生态学
Environment International Pub Date : 2026-09-01 Epub Date: 2026-09-02 DOI: 10.1016/j.envint.2026.110504
Stephanie Selke, Martin Koenig, Nadia Obi, Sinah Riem, Anna Köttgen, Michael Leitzmann, Natalie Reimers, Volker Harth
{"title":"Analysis of ultra short-chain PFAS in urine: method development by LC-MS/MS and first human biomonitoring results from the German National Cohort (NAKO)","authors":"Stephanie Selke,&nbsp;Martin Koenig,&nbsp;Nadia Obi,&nbsp;Sinah Riem,&nbsp;Anna Köttgen,&nbsp;Michael Leitzmann,&nbsp;Natalie Reimers,&nbsp;Volker Harth","doi":"10.1016/j.envint.2026.110504","DOIUrl":"10.1016/j.envint.2026.110504","url":null,"abstract":"<div><div>Ultra short-chain perfluoroalkyl substances (USC PFAS) with C1-C3 chain lengths are increasingly important. Globally, trifluoroacetic acid (TFA) makes up the largest proportion of PFAS in the environment, however, knowledge about human internal exposure to these substances is scarce. We present a new, fast and robust human biomonitoring (HBM) method to quantify simultaneously 5 USC PFAS in urine. A simple dilute and shoot method based on liquid chromatography-tandem mass spectrometry using isotope dilution was developed, validated and applied in a HBM pilot study using samples from a population-based subsample of the general population. It showed linearity up to 75 µg/L, low limits of quantification (LOQ 0.05–1.5 μg/L), satisfactory matrix spiked mean relative recoveries (95–107 %) and overall precision (VC 2.9–12 %). In an initial set of two longitudinal samples from 150 participants, aged 21–69 years, of the German National Cohort Hamburg study center, TFA was detected in all samples, ranging from 2.96 to 1512 µg/L. Trifluoromethanesulfonic acid (TFMS) was detected in 73 % and quantified in 8 % of samples, providing first evidence of its occurrence in urine. All other analytes were below LOQ in all samples. Adjusted linear regression analyses showed that baseline TFA levels increased across five age groups and year of examination. From baseline (2015–2019) to follow-up (2020–2024) median of TFA increased on average by 1.6-fold, independent of aging. These are the first longitudinal data on TFA internal exposure among adults from a German metropolitan region, revealing the need for analyzing potential predictors of exposure over time.</div></div>","PeriodicalId":308,"journal":{"name":"Environment International","volume":"215 ","pages":"Article 110504"},"PeriodicalIF":10.2,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148895552","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Retraction notice to “High-throughput screening of ancient forest plant extracts shows cytotoxicity towards triple-negative breast cancer” [Environ. Int. 181 (2023) 108279] 对“高通量筛选古森林植物提取物显示对三阴性乳腺癌的细胞毒性”的撤回通知[环境]。Int. 181(2023) 108279]。
IF 10.2 1区 环境科学与生态学
Environment International Pub Date : 2026-09-01 Epub Date: 2026-09-03 DOI: 10.1016/j.envint.2026.110443
Yiyang Li, Nyuk Ling Ma, Huiling Chen, Jiateng Zhong, Dangquan Zhang, Wanxi Peng, Su Shiung Lam, Yafeng Yang, Xiaochen Yue, Lijun Yan, Ting Wang, Bjarne Styrishave, Tomasz Maciej Ciesielski, Christian Sonne
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引用次数: 0
Metabolomic signatures and sex-specific associations of prenatal per- and polyfluoroalkyl substances exposure with fetal growth: A meet-in-the-middle and high-dimensional mediation analysis 产前全氟和多氟烷基物质暴露与胎儿生长的代谢组学特征和性别特异性关联:一项中高维度中介分析
IF 11.8 1区 环境科学与生态学
Environment International Pub Date : 2026-08-14 DOI: 10.1016/j.envint.2026.110461
Zhen-Hua Li, Cheng-Yang Hu, Xia-Juan Lu, Meng-Na Zhu, Shao-Lei Pu, Rui He, Kai Huang, Mao-Lin Chen, Guo-Peng Gao, Fang-Biao Tao, Xiu-Jun Zhang
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引用次数: 0
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