Haitong Zhe Sun , Han Chen , Yijia Tian , Zekun Wang , Juan Zhou , Lina Zhang , Jing Fang , Juan Gao , Kim Robin van Daalen , Lynette P. Shek , Wei Jie Seow , Yuming Guo , Nick Watts , Xiaoxia Bai
{"title":"环境空气颗粒物和臭氧暴露对低出生体重的协同风险:一项为期11年的中国产妇纵向队列研究","authors":"Haitong Zhe Sun , Han Chen , Yijia Tian , Zekun Wang , Juan Zhou , Lina Zhang , Jing Fang , Juan Gao , Kim Robin van Daalen , Lynette P. Shek , Wei Jie Seow , Yuming Guo , Nick Watts , Xiaoxia Bai","doi":"10.1016/j.envint.2025.109640","DOIUrl":null,"url":null,"abstract":"<div><div>Observational epidemiological studies have demonstrated that maternal exposure to air pollution increases the risk of adverse pregnancy outcomes. However, interactions among multiple environmental exposures remain underexplored. In this study, we performed an epidemiological analysis on 147,979 pregnant women recruited from nine provinces in southeastern China between 2013 and 2023, focusing on the risk of low birth weight (LBW). We found that the critical exposure windows for PM<sub>2.5</sub> and ozone (O<sub>3</sub>) extend from six months prior to conception through the end of second trimester, with hazard ratio of HR = 1.152 (95 % confidence interval [CI]: 1.128–1.177) per 10-μg/m<sup>3</sup> incremental PM<sub>2.5</sub> exposure and HR = 1.028 (95 % CI: 1.024–1.031) per 10-ppb increase in O<sub>3</sub>. Our estimates indicate that in 2021, approximately 47,500 (95 % uncertainty interval [UI]: 41,200–53,600) live-born LBW infants nationwide in China could be attributed to ambient air pollution, declining from 79,800 (95 % UI: 71,700–87,900) in 2002. We observed statistically significant synergistic risk effects, neglecting which could lead to an underestimation of 11,600 (95 % UI: 9,300–13,900) LBW cases. Although air pollution-associated LBW burden is decreasing, the rapidly rising LBW prevalence remains a significant public health concern, particularly as China is implementing the “three-child policy”. Therefore, our study offers precisely quantified, evidence-based policy guidance for safeguarding reproductive health.</div></div>","PeriodicalId":308,"journal":{"name":"Environment International","volume":"202 ","pages":"Article 109640"},"PeriodicalIF":9.7000,"publicationDate":"2025-06-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Synergistic risks of ambient air particulate matter and ozone exposure on low birth weight: An 11-year longitudinal Chinese maternity cohort study\",\"authors\":\"Haitong Zhe Sun , Han Chen , Yijia Tian , Zekun Wang , Juan Zhou , Lina Zhang , Jing Fang , Juan Gao , Kim Robin van Daalen , Lynette P. Shek , Wei Jie Seow , Yuming Guo , Nick Watts , Xiaoxia Bai\",\"doi\":\"10.1016/j.envint.2025.109640\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><div>Observational epidemiological studies have demonstrated that maternal exposure to air pollution increases the risk of adverse pregnancy outcomes. However, interactions among multiple environmental exposures remain underexplored. In this study, we performed an epidemiological analysis on 147,979 pregnant women recruited from nine provinces in southeastern China between 2013 and 2023, focusing on the risk of low birth weight (LBW). We found that the critical exposure windows for PM<sub>2.5</sub> and ozone (O<sub>3</sub>) extend from six months prior to conception through the end of second trimester, with hazard ratio of HR = 1.152 (95 % confidence interval [CI]: 1.128–1.177) per 10-μg/m<sup>3</sup> incremental PM<sub>2.5</sub> exposure and HR = 1.028 (95 % CI: 1.024–1.031) per 10-ppb increase in O<sub>3</sub>. Our estimates indicate that in 2021, approximately 47,500 (95 % uncertainty interval [UI]: 41,200–53,600) live-born LBW infants nationwide in China could be attributed to ambient air pollution, declining from 79,800 (95 % UI: 71,700–87,900) in 2002. We observed statistically significant synergistic risk effects, neglecting which could lead to an underestimation of 11,600 (95 % UI: 9,300–13,900) LBW cases. Although air pollution-associated LBW burden is decreasing, the rapidly rising LBW prevalence remains a significant public health concern, particularly as China is implementing the “three-child policy”. Therefore, our study offers precisely quantified, evidence-based policy guidance for safeguarding reproductive health.</div></div>\",\"PeriodicalId\":308,\"journal\":{\"name\":\"Environment International\",\"volume\":\"202 \",\"pages\":\"Article 109640\"},\"PeriodicalIF\":9.7000,\"publicationDate\":\"2025-06-27\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Environment International\",\"FirstCategoryId\":\"93\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S0160412025003915\",\"RegionNum\":1,\"RegionCategory\":\"环境科学与生态学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"ENVIRONMENTAL SCIENCES\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Environment International","FirstCategoryId":"93","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S0160412025003915","RegionNum":1,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"ENVIRONMENTAL SCIENCES","Score":null,"Total":0}
Synergistic risks of ambient air particulate matter and ozone exposure on low birth weight: An 11-year longitudinal Chinese maternity cohort study
Observational epidemiological studies have demonstrated that maternal exposure to air pollution increases the risk of adverse pregnancy outcomes. However, interactions among multiple environmental exposures remain underexplored. In this study, we performed an epidemiological analysis on 147,979 pregnant women recruited from nine provinces in southeastern China between 2013 and 2023, focusing on the risk of low birth weight (LBW). We found that the critical exposure windows for PM2.5 and ozone (O3) extend from six months prior to conception through the end of second trimester, with hazard ratio of HR = 1.152 (95 % confidence interval [CI]: 1.128–1.177) per 10-μg/m3 incremental PM2.5 exposure and HR = 1.028 (95 % CI: 1.024–1.031) per 10-ppb increase in O3. Our estimates indicate that in 2021, approximately 47,500 (95 % uncertainty interval [UI]: 41,200–53,600) live-born LBW infants nationwide in China could be attributed to ambient air pollution, declining from 79,800 (95 % UI: 71,700–87,900) in 2002. We observed statistically significant synergistic risk effects, neglecting which could lead to an underestimation of 11,600 (95 % UI: 9,300–13,900) LBW cases. Although air pollution-associated LBW burden is decreasing, the rapidly rising LBW prevalence remains a significant public health concern, particularly as China is implementing the “three-child policy”. Therefore, our study offers precisely quantified, evidence-based policy guidance for safeguarding reproductive health.
期刊介绍:
Environmental Health publishes manuscripts focusing on critical aspects of environmental and occupational medicine, including studies in toxicology and epidemiology, to illuminate the human health implications of exposure to environmental hazards. The journal adopts an open-access model and practices open peer review.
It caters to scientists and practitioners across all environmental science domains, directly or indirectly impacting human health and well-being. With a commitment to enhancing the prevention of environmentally-related health risks, Environmental Health serves as a public health journal for the community and scientists engaged in matters of public health significance concerning the environment.