Environmental PollutionPub Date : 2026-11-15Epub Date: 2026-09-07DOI: 10.1016/j.envpol.2026.129120
Ling Sun, Xiaoyan Yang, Mengdi Li, Honglei Ji, Lihua Li, Yan Huo, Haohan Zou, Yan Wang
{"title":"Association of long-term exposure to ambient air pollution and myopia in Chinese children.","authors":"Ling Sun, Xiaoyan Yang, Mengdi Li, Honglei Ji, Lihua Li, Yan Huo, Haohan Zou, Yan Wang","doi":"10.1016/j.envpol.2026.129120","DOIUrl":"10.1016/j.envpol.2026.129120","url":null,"abstract":"<p><p>Ambient air pollution is recognized as a major global health concern, but evidence on its association with childhood myopia remains limited, particularly under multi-pollutant exposure conditions. A school-based study was conducted in Tianjin, China, including 212,566 students in grades 4-6. The 3-yr mean concentrations of particulate matter with aerodynamic diameter ≤ 2.5 μm (PM<sub>2.5</sub>), its major components (sulfate (SO<sub>4</sub><sup>2-</sup>), nitrate (NO<sub>3</sub><sup>-</sup>), ammonium (NH<sub>4</sub><sup>+</sup>), organic matter (OM), and black carbon (BC)), and ozone (O<sub>3</sub>) were estimated using machine-learning exposure models and linked to school locations. Restricted cubic splines and quartile-based modified Poisson models were used to assess single-pollutant exposure-response relationships, and quantile-based g-computation was applied to estimate joint pollutant associations. In single-pollutant models, the highest quartile of SO<sub>4</sub><sup>2-</sup> was associated with higher myopia prevalence compared with the lowest quartile (PR = 1.10; 95% CI, 1.07-1.13). O<sub>3</sub> showed weaker and non-monotonic positive patterns (Q4 vs Q1: PR = 1.03; 95% CI, 1.00-1.05). In mixture analyses, a one-quartile increase in joint exposure was associated with higher myopia prevalence (PR = 1.017; 95% CI, 1.007-1.027). Sensitivity analyses generally supported the direction of the main findings. These findings suggest that long-term exposure to specific ambient air pollutants may be associated with myopia in school-aged children.</p>","PeriodicalId":311,"journal":{"name":"Environmental Pollution","volume":" ","pages":"129120"},"PeriodicalIF":7.2,"publicationDate":"2026-11-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148904687","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Cu disrupts the olfacto-retinal centrifugal pathway and mediates reduced feeding-related behavior in zebrafish (Danio rerio).","authors":"Cheng Lou, Hongxing Chen, Wenji Zhou, Hongyan Lin, Xinyue Xie, Xin Zhang, Zikui Chen, Fangli Wu, Ting Huang, Yongju Luo, Lingtian Xie","doi":"10.1016/j.envpol.2026.129126","DOIUrl":"10.1016/j.envpol.2026.129126","url":null,"abstract":"<p><p>Cu is an environmental trace metal, but excess Cu is known to disrupt chemosensory functions. However, the chronic effects on the olfacto-retinal centrifugal (ORC) pathway and feeding-related behavior of Cu in fish remain largely uncharacterized. Zebrafish (Danio rerio, six-month-old) were exposed to environmentally relevant concentrations of Cu (i.e., 1.6, 5.6, 16, and 35 μg L<sup>-1</sup>; Cont, Cu-L, Cu-M, and Cu-H) over a 30-day period. Behavioral, neurochemical, and transcriptional biomarkers were measured to evaluate toxic effects of Cu. The results demonstrated that Cu significantly accumulated in olfactory tissues, eyes, and brains. Cu induced divergent olfactory and visual impairments in female and male fish. It markedly impaired olfactory signal transduction and processing (e.g., gnal; ∼56% decrease), while visual function was more severely impaired in females (e.g., a 48% decrease in velocity during visually guided behavior). Correlation analysis further showed that Cu induced coordinated changes between olfactory tissue and eyes. Meanwhile, such olfactory and visual impairments, together with altered neurotransmitter levels and disruptive appetite regulation (e.g., ∼1.2-fold increases in the orexigenic neuropeptide Y (NPY) and the anorexigenic pro-opiomelanocortin (POMC)), may collectively contribute to the 6.0-17% decline in feeding-related behavior. Our findings suggest that Cu-induced feeding suppression may involve disrupted ORC pathway and sex-dependent appetite regulation, providing critical insights into the ecological risks of Cu contamination.</p>","PeriodicalId":311,"journal":{"name":"Environmental Pollution","volume":" ","pages":"129126"},"PeriodicalIF":7.2,"publicationDate":"2026-11-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148910175","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Environmental PollutionPub Date : 2026-11-15Epub Date: 2026-09-04DOI: 10.1016/j.envpol.2026.129081
Muhammad Haseeb Ullah, Jun Zhu, Wen-Jie Yan, Aliya Fazal, Zhen-Xin Liu, GuLiZaEr KuErBan, Farheen Zafar, Xu Yue
{"title":"Transboundary biomass-burning influence on springtime PM<sub>2.5</sub> population exposure across southern China during 2015-2019.","authors":"Muhammad Haseeb Ullah, Jun Zhu, Wen-Jie Yan, Aliya Fazal, Zhen-Xin Liu, GuLiZaEr KuErBan, Farheen Zafar, Xu Yue","doi":"10.1016/j.envpol.2026.129081","DOIUrl":"10.1016/j.envpol.2026.129081","url":null,"abstract":"<p><strong>Background: </strong>Every spring (March-April), biomass-burning fires in the Indo-China Peninsula (ICP) send smoke downwind into southern China, coinciding with elevated springtime PM<sub>2.5</sub> in Yunnan, Guangxi, and Guangdong. The radiative and ecological effects of this transport are established, but its springtime population-exposure burden remains poorly characterised.</p><p><strong>Objective: </strong>To quantify springtime PM<sub>2.5</sub> population exposure under WHO and Chinese benchmarks, and attribute the ICP fire contribution with a controlled model experiment.</p><p><strong>Methods: </strong>Daily PM<sub>2.5</sub> from 51 cities was combined with WorldPop population data to compute exposure above the WHO 2021 guideline (24-h, 15 μg/m<sup>3</sup>) and China's GB 3095-2012 Grade II standard (75 μg/m<sup>3</sup>) for March-April 2015-2019, and paired GEOS-Chem simulations at 2° × 2.5° with and without ICP fire attributed the fire contribution.</p><p><strong>Results: </strong>At observed PM<sub>2.5</sub> concentrations, exposure above the WHO 24-h guideline was near-universal (the population-weighted share of exceedance days reached 78 to 96% every year). Exposure above the higher China Grade II standard was rare in all three provinces, with the population-weighted share of exceedance days spanning 1 to 6% in Yunnan, 1 to 6% in Guangxi, and 0 to 5% in Guangdong; in absolute terms this corresponds to an average daily exposed population of about 6 million across the corridor, under 3% of its residents, with Guangdong's larger population offsetting its lower exceedance fraction. A controlled GEOS-Chem experiment with and without ICP fire attributed 25% (9.6 μg/m<sup>3</sup>) of Yunnan's springtime PM<sub>2.5</sub> to ICP burning, 6% (3.3 μg/m<sup>3</sup>) in Guangxi and 4% (1.6 μg/m<sup>3</sup>) in Guangdong, a monotonic west-to-east gradient paralleled by ozone (10%, 5%, 2%). Translating this attribution into exposure, ICP fire carried an estimated average daily population of 2.2-2.6 million above the China PM<sub>2.5</sub> standard (36-44% of all above-standard exposure), and about 11 million above the WHO ozone guideline.</p><p><strong>Conclusions: </strong>The model-attributed ICP-fire contribution is largest in Yunnan and attenuates eastward, while national-standard exceedance remains episodic across the corridor; this pattern supports province-specific, transport-aware air-quality assessment.</p>","PeriodicalId":311,"journal":{"name":"Environmental Pollution","volume":" ","pages":"129081"},"PeriodicalIF":7.2,"publicationDate":"2026-11-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148890524","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Environmental PollutionPub Date : 2026-11-15Epub Date: 2026-09-03DOI: 10.1016/j.envpol.2026.129087
Marion S Deville-Cavellin, Maxime Rome, Cindy Arnoldi, Delphine Rioux, Julien Renaud, Sylvain Campillo-Cressot, Sabine Sentenac, Stéphane Guedron, Magali Rossi, David Gateuille, Muriel Raveton, Florian C Boucher
{"title":"Rapid and exceptionally small-scale adaptation of the alpine plant Cardamine resedifolia to mining-contaminated soils in multi-stress condition.","authors":"Marion S Deville-Cavellin, Maxime Rome, Cindy Arnoldi, Delphine Rioux, Julien Renaud, Sylvain Campillo-Cressot, Sabine Sentenac, Stéphane Guedron, Magali Rossi, David Gateuille, Muriel Raveton, Florian C Boucher","doi":"10.1016/j.envpol.2026.129087","DOIUrl":"10.1016/j.envpol.2026.129087","url":null,"abstract":"<p><p>The mechanisms by which plants tolerate soil contamination have been studied in details in controlled laboratory conditions, but they still remain largely unexplored in natural conditions where mixtures of contaminants are present in soils and their effects might interact with other environmental variables. This is especially true in high-altitude alpine environments, where abiotic stress is naturally heightened, but which so far have received little attention in environmental pollution studies. As we were interested in the tolerance mechanisms at play on very fine spatiotemporal scales for alpine plants growing under multi-stress conditions, we chose Cardamine resedifolia as our biological model. This plant is indeed frequently found in areas contaminated by Trace Metals and Metalloids and Polycyclic Aromatic Hydrocarbons in high elevation. We studied populations from former copper, silver-lead, and coal mines in alpine environments, along with populations growing on nearby reference soils. We measured genetic variability within populations as well as genetic differentiation between them, and tested for local adaptation to soil contamination using reciprocal transplants. Population pairs showing signs of local adaptation were then examined using genome scans to identify genes potentially under selection. We found high levels of genetic differentiation between populations growing on contaminated and reference soils a few dozen meters apart. In most cases local adaptation was detected, especially in former copper mines. Genome scans identified genes involved in metal stress management as potentially being under selection. This study provides evidence for rapid adaptation to human-induced pollution in alpine plants at remarkably small spatial scales. It offers new insights into the short-term ecological and evolutionary consequences of mining activities in alpine ecosystems, particularly in relation to substrate-driven differentiation.</p>","PeriodicalId":311,"journal":{"name":"Environmental Pollution","volume":" ","pages":"129087"},"PeriodicalIF":7.2,"publicationDate":"2026-11-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148885887","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Environmental PollutionPub Date : 2026-11-15Epub Date: 2026-09-07DOI: 10.1016/j.envpol.2026.129110
Yuan Sun, Junbin Zhang, Huixue Li, Jiajia Wu, Yuqing Chen, Youling Zhong, Shaobo Zheng, Zhiyin Ye, Xiangfei Kong, Xin Song, Neng Yan, Maoliang Su
{"title":"Silver nanoparticles trigger pronounced immunotoxicity via disrupting gut microbiota in estuarine fish: a study highlighting particle size and the dynamic transformation.","authors":"Yuan Sun, Junbin Zhang, Huixue Li, Jiajia Wu, Yuqing Chen, Youling Zhong, Shaobo Zheng, Zhiyin Ye, Xiangfei Kong, Xin Song, Neng Yan, Maoliang Su","doi":"10.1016/j.envpol.2026.129110","DOIUrl":"10.1016/j.envpol.2026.129110","url":null,"abstract":"<p><p>Silver nanoparticles (Ag<sup>0</sup>-NPs) are among the most widely used nanomaterials, yet current risk assessments predominantly focus on particle size while overlooking the role of dynamic speciation. Here, using the estuarine fish Scatophagus argus, we demonstrated that primary particle size (20, 60, and 100 nm) and the bidirectional Ag<sup>0</sup>-NPs/dissolved Ag <sup>+</sup> interconversion critically governed in vivo toxicity. Our results revealed that Ag exposure induced the most pronounced pro-inflammatory immunotoxicity, characterized by selective enrichment of gut Gram-negative bacteria, lipopolysaccharide (LPS) translocation across a compromised intestinal barrier, and subsequent activation of the TLR/MyD88/NF-κB (Toll-like receptor/myeloid differentiation primary response 88/nuclear factor kappa-B) signaling pathway, an effect most pronounced with 20-nm Ag<sup>0</sup>-NPs and Ag<sup>+</sup> exposure. Counterintuitively, 20-nm Ag<sup>0</sup>-NPs at an environmentally relevant concentration (10 μg/L) caused significantly higher mortality than equimolar Ag<sup>+</sup> exposure (15.75 μg/L AgNO<sub>3</sub>). This disparity arose because administered Ag<sup>+</sup> (∼10%) was rapidly sulfidated into low-bioavailability Ag<sub>2</sub>S-NPs, constituting an endogenous detoxification mechanism, whereas 20-nm Ag<sup>0</sup>-NPs sustained elevated intracellular and luminal Ag <sup>+</sup> levels through continuous dissolution. Prolonged Ag<sup>0</sup>-NPs exposure exacerbated gut microbiota dysbiosis and systemic inflammation. Crucially, fecal microbiota transplantation from exposed donors into germ-free medaka recapitulated elevated serum LPS and enhanced inflammatory response, confirming a causal link between nanoparticle exposure, gut microbiota perturbation, and host immune dysfunction. These findings reveal that the synergistic interplay between particle size and in vivo silver transformation dictates nanotoxicity, underscoring that secondary particle formation and transformation-dependent toxicity are underestimated in conventional risk paradigms.</p>","PeriodicalId":311,"journal":{"name":"Environmental Pollution","volume":" ","pages":"129110"},"PeriodicalIF":7.2,"publicationDate":"2026-11-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148904647","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Environmental PollutionPub Date : 2026-11-15Epub Date: 2026-09-08DOI: 10.1016/j.envpol.2026.129132
Jun Zhan, Yujing Wang, Yilin Shen, Fan Lü, Hua Zhang, Pinjing He
{"title":"Integrating molecular properties and olfactory receptor binding affinities for identifying environmental odorants.","authors":"Jun Zhan, Yujing Wang, Yilin Shen, Fan Lü, Hua Zhang, Pinjing He","doi":"10.1016/j.envpol.2026.129132","DOIUrl":"10.1016/j.envpol.2026.129132","url":null,"abstract":"<p><p>Odorous volatile compounds released from waste and wastewater treatment, soil remediation, industrial manufacturing, and livestock operations have become a growing environmental and public health concern. However, identifying key odor compounds within complex emissions remains a fundamental challenge, as odor impact is governed not solely by chemical concentration, but by the odor detection thresholds (ODTs) and odor qualities. Although machine-learning approaches have shown promise in predicting odor characteristics of compounds, existing models primarily rely on molecular physicochemical properties while overlooking the biological interactions between odorants and the human olfactory system. Here, a computational framework integrating molecular descriptors, structural fingerprints, and simulated molecule-olfactory receptor (OR) binding affinities was developed to predict ODTs and odor qualities of volatile compounds. Our framework outperforms conventional physicochemical-based models, with particularly strong discriminative capability for garlic, alliaceous, and sulfurous odors-compound classes commonly associated with odor pollution. The molecular polarity, structural complexity, and OR binding affinity are further identified as prior factors for odor perception. Key ORs governing ODT and odor quality predictions are separately pinpointed. By bridging odorant-OR interaction and molecular information, this framework offers a practical tool for screening unknown environmental odorants, supporting targeted odor pollution management, regulatory threshold setting, and development of environmental monitoring strategies.</p>","PeriodicalId":311,"journal":{"name":"Environmental Pollution","volume":" ","pages":"129132"},"PeriodicalIF":7.2,"publicationDate":"2026-11-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148910132","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Global freshwater resistomes reveal environmental signatures associated with the burden of drug-resistant tuberculosis.","authors":"Tong Li, Jiahui Lv, Yunye Tu, Li Cheng, Hongjun Xiao, Yanping Sun, Jia-Xin Li, Mingkun Lv, Jingkai Yang, Guanghui Wang, Zexi Tang, Yajie Liu, Hancheng Song, Shaokang Zhao, Pan-Lin Shao, Bo Zhang","doi":"10.1016/j.envpol.2026.129105","DOIUrl":"10.1016/j.envpol.2026.129105","url":null,"abstract":"<p><p>Antimicrobial resistance (AMR) is a growing global health threat, yet the extent to which environmental resistomes reflect human disease burden remains unclear. In this study, we provide the first attempt to bridge freshwater resistomes with human disease burden using machine learning models, with a focus on identifying environmental signatures associated with drug-resistant tuberculosis (DR-TB) burden. By analyzing 1280 freshwater metagenomes from 45 countries, we characterized the compositional distribution of the resistomes and further developed an integrated environmental AMR Risk Score. Integrating the AMR Risk Score with socio-economic variables provided complementary information associated with variation in multidrug-resistant tuberculosis burden beyond socio-economic factors alone. In complementary income-stratified analyses, feature selection identified recurrent environmental signatures associated with different drug-resistant tuberculosis subgroups. These findings indicate that freshwater resistome characteristics contain geographically structured information associated with DR-TB burden within the sampled datasets and support the potential value of freshwater metagenomic surveillance for characterizing environmental AMR patterns.</p>","PeriodicalId":311,"journal":{"name":"Environmental Pollution","volume":" ","pages":"129105"},"PeriodicalIF":7.2,"publicationDate":"2026-11-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148885934","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Environmental PollutionPub Date : 2026-11-15Epub Date: 2026-09-02DOI: 10.1016/j.envpol.2026.129083
Yoshihito Ohtsuka, Shun'ichi Hisamatsu
{"title":"Background activity concentrations of radionuclides and internal dose rates in the wild mouse and shrew mole in forests of Rokkasho, Aomori Prefecture, Japan.","authors":"Yoshihito Ohtsuka, Shun'ichi Hisamatsu","doi":"10.1016/j.envpol.2026.129083","DOIUrl":"10.1016/j.envpol.2026.129083","url":null,"abstract":"<p><p>Understanding baseline internal radiation exposure in small terrestrial mammals is essential for evaluating potential radiological impacts associated with nuclear facilities. We quantified naturally occurring and artificial radionuclides in two representative forest-dwelling species-the small Japanese field mouse (Apodemus argenteus) and the Japanese shrew mole (Urotrichus talpoides)-collected from three forest types in Rokkasho, Aomori Prefecture, Japan, prior to the operation of a commercial spent nuclear fuel reprocessing plant. Activity concentrations of <sup>14</sup>C, <sup>40</sup>K, <sup>210</sup>Po, <sup>210</sup>Pb, <sup>226</sup>Ra, <sup>232</sup>Th, <sup>238</sup>U, and <sup>137</sup>Cs were measured in whole-body composite samples or in 11 organs/tissues. The shrew mole exhibited markedly higher <sup>210</sup>Po activity concentrations-approximately one order of magnitude greater than those of the mouse-likely reflecting its carnivorous feeding habits. Seasonal variations were observed in several organs, particularly for <sup>210</sup>Po. Internal dose rates were estimated using the ERICA Tool, yielding mean values of 0.25 ± 0.08 μGy h<sup>-1</sup> for the mouse and 4.1 ± 1.4 μGy h<sup>-1</sup> for the shrew mole, with <sup>210</sup>Po contributing 70-98% of the total dose rate. These results provide essential baseline data for future environmental radiological assessments and for interpreting radiation effects in wildlife inhabiting regions affected by nuclear accidents, such as Fukushima. Continued monitoring of naturally occurring radionuclides, particularly <sup>210</sup>Po, will be essential for accurate ecological risk assessments and for distinguishing background variability from accident-derived contamination.</p>","PeriodicalId":311,"journal":{"name":"Environmental Pollution","volume":" ","pages":"129083"},"PeriodicalIF":7.2,"publicationDate":"2026-11-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148878612","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}