环境科学与生态学最新文献

{"title":"Circulation in the Guafo Mouth: The gateway to northern Patagonia","authors":"Lauren Ross ,&nbsp;Iván Pérez-Santos ,&nbsp;Pamela Linford ,&nbsp;Patricio A. Díaz","doi":"10.1016/j.scitotenv.2025.179512","DOIUrl":"10.1016/j.scitotenv.2025.179512","url":null,"abstract":"<div><div>Circulation and exchange are important factors governing material transport in all coastal areas, including Chilean Patagonia, a region that boasts one of the largest aquaculture industries in the world and provides habitat for several protected marine mammal species. Linkages between coastline shape and forces of hydraulic conditions, such as tides, wind, sea level gradients, and river discharge are thereby important considerations when understanding constituent concentrations and transport related to water quality issues, which threaten aquaculture activities and endanger wildlife and humans. The primary connection between the Pacific Ocean and the fjords of Chilean Patagonia is through the Guafo Mouth, however the structure and drivers of circulation, and its impact on water quality, has yet to be studied. The research presented here characterizes circulation patterns and variability in the Guafo Mouth to help inform ocean-fjord exchange. Measurements of current velocities, salinity, temperature, dissolved oxygen, and nutrients were collected from 2020 to 2023 in the channel. These measurements, in addition to a numerical model of the study area and reanalysis data, provide parallel evidence of subtidal flows driven by the competition between barotropic and baroclinic pressure gradients. Depending on the sign of the barotropic pressure gradient, the barotropic flow either augments (when negative) or opposes (when positive) the circulation produced by horizontal density gradients. When the near-bottom subtidal inflow enhances, offshore waters with high nutrient content and low dissolved oxygen can be advected in-channel. This occurred at periods between ∼40 and 70 d concurrent with poleward pulses of the Peru-Chile Undercurrent that is known to transport nutrient rich and low dissolved oxygen waters southward off the coast of Chile. These findings imply that ocean-fjord exchange through the Guafo Mouth, which is controlled by water level gradients from the Pacific Ocean to the inner fjords, directly influences the import of dissolved oxygen and nutrients.</div></div>","PeriodicalId":422,"journal":{"name":"Science of the Total Environment","volume":"979 ","pages":"Article 179512"},"PeriodicalIF":8.2,"publicationDate":"2025-04-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143877567","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Network toxicological and molecular docking in investigating the mechanisms of toxicity of agricultural chemical pyraclostrobin","authors":"Shen-sui Li ,&nbsp;Xu-dong Tian ,&nbsp;Ju-kun Song ,&nbsp;Ya-dong Wu ,&nbsp;Wei-li Wang ,&nbsp;Zheng-long Tang ,&nbsp;Jin-bo Wang","doi":"10.1016/j.ecoenv.2025.118244","DOIUrl":"10.1016/j.ecoenv.2025.118244","url":null,"abstract":"<div><div>The safety of agricultural products is significant to human health. Pyraclostrobin (PYR), a common methoxycarbonyl fungicide, is a crucial role in the prevention of fungal infections during the transport and storage of agricultural products, including vegetables and fruits. Using a multi-analytical approach, integrating toxicological database mining, protein-protein interaction (PPI) network analysis, and molecular docking, this study aimed to elucidate the molecular mechanisms underlying the toxicity of PYR. A total of 162 and 129 targets were identified for cancer and kidney injury, respectively, with PPI analysis pinpointing five vital targets per condition. Functional enrichment through Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genome (KEGG) pathway annotations revealed significant associations with pathways related to prostate cancer and renal impairment pathways. Molecular docking confirmed PYR's binding affinity to these targets, indicating its potential role in disease pathogenesis. Our findings underscore the imperative for stringent safety assessments of PYR, particularly concerning the risks posed by chronic exposure, and emphasize the urgency for further research to inform public health and environmental policies.</div></div>","PeriodicalId":303,"journal":{"name":"Ecotoxicology and Environmental Safety","volume":"297 ","pages":"Article 118244"},"PeriodicalIF":6.2,"publicationDate":"2025-04-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143876852","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Green gentrification drives socio-cultural shifts from provisioning to cultural valuation of ecosystem services","authors":"Celina Aznarez ,&nbsp;Juan Pablo Pacheco ,&nbsp;María Candelaria Domínguez ,&nbsp;Isabel Gadino ,&nbsp;Hugo Inda ,&nbsp;Fabiana Castellarini","doi":"10.1016/j.ecoser.2025.101731","DOIUrl":"10.1016/j.ecoser.2025.101731","url":null,"abstract":"<div><div>Gentrification influences the social distribution of Ecosystem Services (ES) which can affect their use, perception and valuation, and lead to socio-ecological conflicts. This is particularly evident in coastal urban areas, where local underprivileged communities depending on ES for their livelihoods are often displaced due to real estate and tourism activities. Here, we analyse the use, perception and valuation of ES regarding the socio-economic status in a gentrified coastal area in Uruguay with an ongoing plan of urban transformation. We combined semi-structured interviews, participatory observation and mapping, for the identification, valuation, frequency of use, main pressures and trade-offs of ES. We evidenced a contrasting use and valuation of ES between neighbourhoods of different socio-economic status. Affluent neighbourhoods mainly recognized cultural-recreational ES, with sporadic use during summertime. Contrarily, residents of underprivileged areas identified a wider range of ES, used all year long, and had a higher valuation of provisioning ES due to their high dependence for basic needs. Accelerated gentrification, driven by the local urban management plan might exacerbate ES distributive inequities, and raise environmental justice concerns due to the restricted access to ES by the highly reliant underprivileged residents. This might induce a homogenisation in the use and valuation of ES towards cultural-recreational ones, more used and valued by affluent users. We emphasise the need for inclusive urban planning that acknowledges and integrates the diverse values and dependencies on ES across different socio-economic groups, to ensure sustainable and equitable development, preserve local livelihoods, and maintain ecological integrity.</div></div>","PeriodicalId":51312,"journal":{"name":"Ecosystem Services","volume":"73 ","pages":"Article 101731"},"PeriodicalIF":6.1,"publicationDate":"2025-04-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143877538","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"How are diameter growth, forest structure and carrying capacity related in tree populations?","authors":"Thiago Floriani Stepka ,&nbsp;Patrícia Povoa de Mattos ,&nbsp;Afonso Figueiredo Filho ,&nbsp;Sebastião do Amaral Machado ,&nbsp;Evaldo Muñoz Braz","doi":"10.1016/j.ecolmodel.2025.111141","DOIUrl":"10.1016/j.ecolmodel.2025.111141","url":null,"abstract":"<div><div>This study modeled the diameter growth of <em>Araucaria angustifolia, Cedrela fissilis</em>, and <em>Ocotea porosa</em> as a function of age and analyzed how these factors are related to diameter distribution. This analysis was used to describe behavior in terms of age and lifespan, and also determined periods of technical growth stagnation for each species. Diameter growth was evaluated via partial trunk analysis using increment cores from 30 trees per species in six study locations in southern Brazil (totaling 480 cores), collected in proportion to diameter distribution. Twelve biological models were utilized to estimate diameter growth as a function of age of the species in the different locations. The Weibull probabilistic density function with three parameters was adjusted to represent the diametric structure and indicate carrying capacity. Distinct ages were identified in the different study locations, indicating successions in separate periods during the past as well as locations with the least alterations (oldest successions). The diameters at the technical age of stagnation and carrying capacity were found to be generally similar, demonstrating the relationship between diameter structure and diameter increment. Maximum vigor in the three species was found to occur at diameters considerably smaller than the maximum value, suggesting that attainment of significant ages and diameters may not fully reflect the inherent potential of all individuals within the species under study. The maximum diameter increment vigor in the species under analysis was observed during the early stages of development, and tended to diminish in the subsequent phases.</div></div>","PeriodicalId":51043,"journal":{"name":"Ecological Modelling","volume":"506 ","pages":"Article 111141"},"PeriodicalIF":2.6,"publicationDate":"2025-04-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143876760","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Using sulfur and oxygen isotope values to partition riverine sulfate sources and illustrate their responses to hydrological processes","authors":"Ying Cao ,&nbsp;Yuxiao He ,&nbsp;Dong Zhang ,&nbsp;Yong Qin ,&nbsp;Zhiqi Zhao ,&nbsp;Cong Zhang ,&nbsp;Shanggui Gong","doi":"10.1016/j.jenvman.2025.125539","DOIUrl":"10.1016/j.jenvman.2025.125539","url":null,"abstract":"<div><div>Orogenesis contributes to the elevation of highly eroded rock strata, whose interactions with the atmosphere, water, and biota result in the release of dissolved substances. The fluvial transport of dissolved sulfate (SO₄²⁻) from mountains to oceans is a critical component of the global sulfur cycle. However, anthropogenic activities have significantly increased the concentrations of sulfate and altered isotope compositions. It is imperative to delineate the impacts of anthropogenic disturbances and clear their transport mechanisms. To address this issue, spatial and temporal water samples were collected from the Qin River Basin (QRB) between 2012 and 2015. Sulfate sulfur and oxygen isotope values (δ³⁴S-SO₄^2- and δ¹⁸O-SO₄^2-), alongside Bayesian isotope mixing models (BIMMs) were employed to identify pathways of anthropogenic inputs and quantify their contributions. The average mainstream SO₄²⁻ concentration, δ³⁴S-SO₄^2- and δ¹⁸O-SO₄^2- values in the upper reaches (<em>n</em> = 18), middle (<em>n</em> = 9), and lower reaches (<em>n</em> = 44) were 1.09 mmol/L, 1.5 ‰ and 5.6 ‰; 1.34 mmol/L, 6.8 ‰ and 6.9 ‰; 2.31 mmol/L, 8.5 ‰ and 7.7 ‰, respectively. BIMMs results from spatial water samples indicated an increasing trend in contributions from gypsum, loess, sewage and chemical fertilizer but a decreasing trend from coal mine drainage (CMD) and pedogenic sulfate sources to riverine sulfate along the river. Results from temporal water samples at the outlet indicated that pedogenic sulfate, CMD, and loess sulfate were transport-limited, conversely, gypsum and chemical fertilizer were source-limited, and sewage has chemostatic behaviors. Despite a significant reduction in annual water discharge since 1956–2000, the average annual sulfate flux from 2013 to 2015 exceeded historical values, with approximately 45 % of riverine sulfate derived from anthropogenic input, and the flow-weighted average δ³⁴S-SO₄^2- and δ¹⁸O‒SO₄^2- values changed to 7.9 ± 1.2 ‰ and 6.4 ± 0.2 ‰. These findings illuminated the profound impacts of anthropogenic inputs on riverine sulfate flux in Qin River and offer a robust methodology for partitioning aqueous pollution sources and delineating their transport mechanisms in the complex environmental settings.</div></div>","PeriodicalId":356,"journal":{"name":"Journal of Environmental Management","volume":"384 ","pages":"Article 125539"},"PeriodicalIF":8.0,"publicationDate":"2025-04-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143877500","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Metabolomic signatures of pathogen suppression effect of Baltic eelgrass meadows in surrounding seawater","authors":"Caroline Utermann-Thüsing ,&nbsp;Daniel Mendez ,&nbsp;Paolo Stincone ,&nbsp;Daniel Petras ,&nbsp;Deniz Tasdemir","doi":"10.1016/j.scitotenv.2025.179518","DOIUrl":"10.1016/j.scitotenv.2025.179518","url":null,"abstract":"<div><div>Organic molecules exuded into water column by marine organisms represent a significant portion of marine dissolved organic matter (DOM) that modulates biochemical interactions. Secreted allelochemicals have been suggested to be involved in regulation of pathogen abundance in seagrass meadows, however, seagrass exometabolome has remained unstudied. We aimed to identify seagrass exometabolites, within and outside meadows, and explore their potential involvement in pathogen suppression under varying environmental conditions. We collected seawater (SW) samples from eelgrass (<em>Zostera marina</em>)-vegetated (V) and non-vegetated (NV) areas across 5 locations spanning 270 km of coastline along the German Baltic Sea. Comparative LC-MS/MS-based untargeted computational metabolomics combined with statistical analyses and machine learning tools were employed to pinpoint (exo)metabolomic signatures of eelgrass leaves. Simultaneously, we measured abiotic parameters and the abundance of three common pathogenic taxa in seawater, and investigated spatiotemporal variations. Here we show the correlation of pathogen biomass and eelgrass pathogen reduction effect with increasing seawater temperature, eutrophication and anthropogenic influences. Exometabolomics studies revealed that eelgrass exudates contributed significantly to overall seawater DOM at molecular level, while SW overlying eelgrass meadows contained many chemical features unique to the eelgrass leaf metabolome. We identified four flavone aglycones as key biomarkers distinguishing SW-V and SW-NV samples. Their drastically increased concentrations correlated with the lowest pathogen biomass, suggesting their role in pathogen regulation. These combined analytical and microbiological approaches indicate that flavones are defensive allelochemicals released into eelgrass meadows upon environmental stress and serve as potential bioindicators of eelgrass’ sanitation effect.</div></div>","PeriodicalId":422,"journal":{"name":"Science of the Total Environment","volume":"979 ","pages":"Article 179518"},"PeriodicalIF":8.2,"publicationDate":"2025-04-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143877526","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Residential indoor temperatures and health: A scoping review of observational studies","authors":"Janelle R. Edwards ,&nbsp;Anneclaire J. De Roos ,&nbsp;Chima C. Hampo ,&nbsp;Wanyu Huang ,&nbsp;Emily Lincoln ,&nbsp;Simi Hoque ,&nbsp;Leah H. Schinasi","doi":"10.1016/j.scitotenv.2025.179377","DOIUrl":"10.1016/j.scitotenv.2025.179377","url":null,"abstract":"<div><div>Adults spend most of their time indoors, especially in higher income countries. Indoor temperature exposures can vary substantially across households, even within a single geographic area. It is therefore critical to understand links between indoor temperature exposures and health or well-being outcomes, and to understand safe maximum indoor residential temperature thresholds that support health, well-being, and comfort. We systematically identified peer-reviewed, observational studies that quantified associations between residential indoor temperatures and mortality/morbidity outcomes. We extracted information on study location; population, health or well-being outcomes; indoor temperature exposure assessment methods; and, when available, empirically quantified safe maximum indoor temperature thresholds. In total, 29 papers were included in the review. The studies were conducted in the following continents: North America (<em>N</em> = 10), Europe (<em>N</em> = 5), Asia (<em>N</em> = 9), Australia (<em>N</em> = 4), and Africa (N = 1). The most common outcomes were cardiovascular morbidity (N = 10) and respiratory morbidity (<em>N</em> = 8) and thermal comfort (<em>N</em> = 9). Exposure assessment methods included data sensors, thermometers, data-driven models, and energy-based simulations. Despite variation in exposure assessment methods and outcomes assessed, results predominately suggested that warmer indoor temperatures were associated with adverse health or well-being outcomes, although in a handful of studies, associations were either null or in the unexpected, protective direction. Empirically identified safe thresholds for indoor temperature ranged from 18 °C to 35 °C and varied according to outcome. Results from this review may be used to inform the design of future studies of associations between indoor temperatures and morbidity or mortality outcomes.</div></div>","PeriodicalId":422,"journal":{"name":"Science of the Total Environment","volume":"979 ","pages":"Article 179377"},"PeriodicalIF":8.2,"publicationDate":"2025-04-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143877507","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Haplotype-specific interactions of Phragmites australis with Spartina alterniflora under salt stress","authors":"Xiao Guo ,&nbsp;Zhihang Sun ,&nbsp;Yufei Gao ,&nbsp;Haijie Zhang ,&nbsp;Qiang Wang ,&nbsp;Xianhu Guo ,&nbsp;Mingyan Li ,&nbsp;Lele Liu ,&nbsp;Jiaao Lu ,&nbsp;Shaoxia Guo ,&nbsp;Shimei Li ,&nbsp;Weihua Guo","doi":"10.1016/j.jenvman.2025.125506","DOIUrl":"10.1016/j.jenvman.2025.125506","url":null,"abstract":"<div><div>Biological invasions present a global environmental challenge, the competitive interactions between native and invasive species constitute a crucial factor in determining the success of invasions. Past research has often treated native species as a monolithic entity when conducting competition experiments with invasive species. In truth, different genotypes may possess substantial differences in functional traits and competitive abilities. Few studies have subdivided widespread native species into distinct subgroups to conduct competitive experiments with invasive species. The invasive <em>Spartina alterniflora</em> and the widespread native <em>Phragmites australis</em> coexist extensively along the coastal regions of China. Through field sample collection and greenhouse common garden experiments, we investigated the salinity tolerance of two common haplotypes of <em>P. australis</em> (haplotype O and haplotype P) in the Yellow River Delta, as well as their relative competitive ability against the invasive <em>S. alterniflora</em> across varying salinity levels. The results showed that under high salinity without competition, the biomass of haplotype O decreased by 46.89 % (haplotype P: 40.0 %), while under low salinity with competition, it decreased by 17.7 % (haplotype P: 25.8 %). The competitive dominance of both haplotypes against <em>S. alterniflora</em> gradually diminished as salinity increased, disappearing under high salinity conditions. Haplotype O exhibited a competitive dominance over <em>S. alterniflora</em> under control and low-salinity stress, whereas haplotype P only showed competitive dominance under control conditions. Our study demonstrates that different genotypes of native species possess varying resistance to invasive species, a consideration that is critical in the practice of using native species for biotic substitution to control invasions.</div></div>","PeriodicalId":356,"journal":{"name":"Journal of Environmental Management","volume":"384 ","pages":"Article 125506"},"PeriodicalIF":8.0,"publicationDate":"2025-04-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143877506","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Bioaccumulation of decabromodiphenylethane (DBDPE) in aquatic and terrestrial biota in the global environment and its toxicological significance assessed by chemical activity","authors":"Kate M. Fremlin ,&nbsp;Nicole Berg ,&nbsp;Frank A.P.C. Gobas","doi":"10.1016/j.scitotenv.2025.179368","DOIUrl":"10.1016/j.scitotenv.2025.179368","url":null,"abstract":"<div><div>Many industrial substances cannot be assessed for their bioaccumulation potential using the octanol-water partition coefficient (<em>K</em>_OW), bioconcentration factor (BCF), or bioaccumulation factor (BAF) criteria typically used in the United Nations Stockholm Convention for Persistent Organic Pollutants (POPs) and in regulations and laws of many countries including Canada, the European Union (EU), the United States (US), and Japan. This presents an impediment to an efficient, effective, and expedient environmental assessment of many substances. However, the Stockholm Convention includes a second criterion for bioaccumulation assessments that is focussed on “<em>Evidence that a chemical presents other reasons for concern, such as high bio-accumulation in other species, high toxicity, or ecotoxicity</em>.” But this criterion has received little attention; is not recognized or used in national regulations; and lacks a framework for evaluation. This study investigates the application of this second criterion to (i) assess the bioaccumulation potential of difficult-to-test and difficult-to-evaluate substances that cannot be adequately evaluated with <em>K</em>_OW, BCF, or BAF due to very low aqueous solubility, ionization poor solubility in lipids, large molecular size, or other reasons; and (ii) present and test a framework for bioaccumulation assessments that aims to determine whether substances bioaccumulate to levels of concern. The framework is tested using evidence of bioaccumulation for decabromodiphenyl ethane (DBDPE; CAS: 84852-53-9), which is a super-hydrophobic substance that is difficult to test in aqueous and dietary bioaccumulation tests. To evaluate DBDPE with this framework, we compiled bioaccumulation and toxicological data from the published literature, evaluated the exposure concentration data for quality, and applied a chemical activity-based evaluation. Our results indicate that based on available information to date, DBDPE does not appear to bioaccumulate to levels of concern that would affect environmental health at a global or local scale. The results also suggest that our evaluative framework may be a useful alternative for other super-hydrophobic and/or ionizing substances like perfluoroalkyl and polyfluoroalkyl substances and/or aromatic brominated flame retardants that cannot be assessed for bioaccumulation potential based on <em>K</em>_OW, BCF, or BAF.</div></div>","PeriodicalId":422,"journal":{"name":"Science of the Total Environment","volume":"979 ","pages":"Article 179368"},"PeriodicalIF":8.2,"publicationDate":"2025-04-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143877612","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Arsenic exposure activates microglia, inducing neuroinflammation and promoting the occurrence and development of Alzheimer's disease-like neurodegeneration in mice","authors":"Bo Zhang ,&nbsp;Jiaojiao Wang ,&nbsp;Junhong Chen ,&nbsp;Xueli Pan","doi":"10.1016/j.ecoenv.2025.118251","DOIUrl":"10.1016/j.ecoenv.2025.118251","url":null,"abstract":"<div><div>Health damage caused by environmental arsenic pollution has attracted widespread attention, with Alzheimer’s disease (AD) thought to be one of the adverse effects of long-term arsenic exposure. In this study, we sought to investigate the relationship between arsenic exposure and AD-like neurodegeneration and to determine the role of microglia in the process of AD-like neurodegeneration induced by arsenic exposure. The relationship between arsenic exposure and AD-like neurodegeneration was investigated using cognitive assessments and biological experiments. Arsenic exposure induced memory impairment in C57BL/6 mice and resulted in a significant increase in the number of Aβ⁺ and pTau⁺ cells in the entorhinal cortex and hippocampus with neuronal granular vacuolar degeneration and necroptosis, accompanied by upregulated expression of related proteins, which showed dose- and time-response relationships. Arsenic exposure intensified memory decline in FAD^4T mice with accelerated AD-like neurodegeneration. Correlation analysis showed a negative correlation between memory impairment and neurodegeneration in the entorhinal cortex and hippocampus in mice. Arsenic exposure also activated microglia in the entorhinal cortex and hippocampus, with enlargement of the cytosol, shortened and thickened cell protrusions, hypertrophic changes, and abnormal proliferation, as well as upregulated expression of the pro-inflammatory cytokines TNF-α and IL-1β. Arsenic exposure induced overactivation of microglia in the entorhinal cortex and hippocampus of FAD^4T mice, resulting in de-branching or bulbous protrusions and fragmented cytoplasm. Our findings suggest that arsenic exposure promotes the occurrence and development of AD-like neurodegeneration via the activation of microglia, which induces neuroinflammation in mice.</div></div>","PeriodicalId":303,"journal":{"name":"Ecotoxicology and Environmental Safety","volume":"297 ","pages":"Article 118251"},"PeriodicalIF":6.2,"publicationDate":"2025-04-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143876853","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}