环境科学与生态学最新文献

{"title":"Retraction notice to \"Sustainable, economical and rapid treatment of multiple lung diseases using therapeutic potential of curcumin nanoparticles\" [Environ. Res. 233 (2023) 116477].","authors":"Qudsia Kanwal, Samiah Shahid, Abeel Ahmad, Arif Nazir, Muhammad Yasir, Aneela Anwar, Samar Z Alshawwa, Munawar Iqbal","doi":"10.1016/j.envres.2025.121959","DOIUrl":"10.1016/j.envres.2025.121959","url":null,"abstract":"","PeriodicalId":312,"journal":{"name":"Environmental Research","volume":" ","pages":"121959"},"PeriodicalIF":7.7,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144223891","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of combined exposures of microcystin-LR and benzo[a]pyrene on detoxification in the fish liver cell line (PLHC-1).","authors":"Flavia Bieczynski, Maja Edenius, Annika Lindkvist, Julio C Painefilú, Andrés Venturino, Carlos M Luquet, Malin C Celander","doi":"10.1016/j.aquatox.2025.107526","DOIUrl":"10.1016/j.aquatox.2025.107526","url":null,"abstract":"<p><p>This study focuses on the mixture effects of two classes of common aquatic contaminants, microcystin-LR (MCLR) and benzo[a]pyrene (BaP), on detoxification in a fish liver cell line (PLHC-1). Cells were exposed to non-cytotoxic concentrations, either MCLR (0.01, 1 µM), BaP (0.01, 0.1, 1 µM), or mixtures of both chemicals for 1 to 48 h. Functions and regulations of cytochrome P450 1A (CYP1A) and P-glycoprotein (Pgp) were analyzed. In addition, cytotoxicity was analyzed to ensure non-cytotoxic effects of any of the treatments. Exposure to MCLR, BaP individually or in different mixture combinations induced CYP1A enzyme activity and CYP1A mRNA expression with differences between individual and mixed exposures. An antagonistic mixture effect was seen on the induction of CYP1A enzyme activity. The half maximal inhibition concentration of BaP on CYP1A activity was 1.7 µM, implying weak inhibition by BaP. In contrast, MCLR had no inhibitory effect, suggesting that the antagonistic mixture effect is not due to inhibition of the CYP1A enzyme by MCLR. However, a synergistic mixture effect was seen on induction of CYP1A mRNA levels at early exposure times (1 and 3 h). At 6 h or longer exposures times, only the highest BaP concentration tested (1 µM) induced CYP1A mRNA expression. Function and regulation of Pgp were not significantly affected in any of the exposure experiments. Besides, none of tested concentrations or mixtures caused cytotoxicity. This study suggests mixture effects between MCLR and BaP at lower concentrations (maximum 1 µM) on function and regulation of CYP1A in a fish liver cell line, providing new insights into the potential adverse mixture effects between these two different classes of aquatic contaminants.</p>","PeriodicalId":248,"journal":{"name":"Aquatic Toxicology","volume":"287 ","pages":"107526"},"PeriodicalIF":4.3,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144797754","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Levonorgestrel-induced anal fin masculinization in mosquitofish: Do TGF-β/BMP signaling and osteogenic remodeling underpin endocrine disruption in aquatic ecosystem?","authors":"Weiqian Liang, Tongfu Lu, Dingxian Chen, Weijian Chen, Kaifeng Wang, Jie Lai, Shengyue Lin, Lin Gui, Jian Gong, Chong Han, Qiang Li","doi":"10.1016/j.aquatox.2025.107527","DOIUrl":"10.1016/j.aquatox.2025.107527","url":null,"abstract":"<p><p>Levonorgestrel (LNG), a common synthetic progestogen, has emerged as an endocrine-disrupting contaminant in aquatic ecosystems. Although recent studies have recognized its androgenic effects, there exist critical gaps in understanding its influence on growth and associated molecular mechanisms. The processes driving anal fin elongation in mosquitofish (Gambusia affinis) following exposure to progestogens, such as LNG, remain poorly characterized. To address these knowledge gaps, we investigated LNG-induced androgenic effects on growth and the molecular basis of anal fin masculinization in adult female mosquitofish exposed to environmentally relevant LNG concentrations (500 ng/L) over a four-week period. Comprehensive physiological and morphological assessments (e.g., Fulton's condition factor, gonadosomatic index, and anal fin/skeletal analyses) revealed significant masculinization in LNG-exposed females. Transcriptomic profiling of anal fin tissue demonstrated that LNG-mediated masculinization and elongation at 500 ng/L were associated with the activation of the transforming growth factor-beta (TGF-β) and bone morphogenetic protein (BMP) signaling pathways. The exposure altered the transcriptional levels of key osteoblast- and osteoclast-related genes (i.e., sp7, col10a1, and nfatc1), implicating dysregulated bone remodeling in fin structural changes. Androgen receptor (ar) expression in anal fin tissue remained unchanged, suggesting that LNG's androgenic effects occurred independently of direct ar transcriptional modulation in this tissue. This study provides the first evidence that LNG disrupts bone morphogenetic and sex-related gene transcription, driving anal fin masculinization in female mosquitofish. These findings advance our understanding of LNG's androgenic impacts and propose the mosquitofish anal fin as a potential biomarker for endocrine disruption. By elucidating molecular pathways linking LNG exposure to morphological changes, this study paves the way for assessing the ecological risks of progestogen pollution in aquatic ecosystems.</p>","PeriodicalId":248,"journal":{"name":"Aquatic Toxicology","volume":"287 ","pages":"107527"},"PeriodicalIF":4.3,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144811474","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Changes in call rate and call level of migrating humpback whales (Megaptera novaeangliae) in response to seismic air guns.","authors":"Riona M McNamara, Rebecca A Dunlop","doi":"10.1016/j.marenvres.2025.107415","DOIUrl":"10.1016/j.marenvres.2025.107415","url":null,"abstract":"<p><p>Seismic air gun operations, used for oil and gas exploration, create intense, impulsive signals that can last for days or months. In response to these signals, baleen whales have been shown to change their feeding, breeding, and migratory behaviours, but with highly variable vocal responses. Some studies show an increase in calling activity and call level, suggesting a response indicative of a Lombard response to noise, whereas others found whales decreased call rate and level, suggesting an avoidance response. This study aimed to determine if humpback whales (Megaptera novaeangliae) significantly altered the rate and/or source level of their social calls in response to seismic air gun signals and determined if any changes were outside of 'normal' baseline vocal behaviour. Air guns ranged in size from a small 20 cubic inch gun to a 3130 cubic inch large commercial array, firing every 11 s and towed along a set transect. Individual humpback whales that were exposed to operational air guns were tagged using suction-cup acoustic tags (n = 12). Within these individuals, call rates and call source levels were compared during exposure to air guns, to before exposure. Then, the call rate and source level of whales exposed to air guns were compared to tagged whales that had not been exposed to air guns (n = 21). Results show that whales exposed to air guns generally increased their call rate and call source level, and these call rates and levels were significantly greater compared to unexposed tagged whales. This is consistent with a Lombard response to noise. However, not all tagged whales responded, nor was there a dose-response relationship between air gun received level, air gun proximity, and vocal response. Humpback whales' vocal responses to air guns are inconsistent and may be context-dependent, emphasising the need to understand how whales perceive these signals to assess the true ecological impact of air gun noise.</p>","PeriodicalId":18204,"journal":{"name":"Marine environmental research","volume":"211 ","pages":"107415"},"PeriodicalIF":3.2,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144799550","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Multi-omics approaches provide insights into adaptation to low salinity of intertidal clams.","authors":"Zihan Lin, Honglei Wang, Geqi Gao, Hongtao Nie, Kai Ye, Donghong Niu, Jiale Li","doi":"10.1016/j.marenvres.2025.107467","DOIUrl":"10.1016/j.marenvres.2025.107467","url":null,"abstract":"<p><p>Climate change is reshaping the population distribution of intertidal organisms, with extreme weather inducing salinity fluctuations that challenge intertidal bivalves. In this study, we employed comparative genomics and transcriptomic analyses to investigate the molecular mechanisms underlying low-salinity adaptation in the razor clam (Sinonovacula constricta). We compiled and analyzed genomic data from 19 molluscan species, classified as either euryhaline or stenohaline based on their salinity tolerance. Phylogenetic analysis suggested that partial Venerida clams may have been evolved into adaptation to low salinity environments at 86.45 Mya (million year ago), or earlier. A total of 440 genes in S. constricta genome were detected to be under positive selection through within-species comparison. Furthermore, we identified sixty-nine lipid metabolism-associated orthologous groups (OGs), including four specially expanded gene families in five intertidal bivalves. Additionally, we constructed twenty-seven transcriptomic libraries from gill, mantle and digestive gland tissues of S. constricta, revealing the species employs complex molecular mechanisms in response to low-salinity stress. Twenty-eight positive selected genes exhibited significant differential expression in razor clam transcriptomic data. By integrating genomic and transcriptomic data, we identified candidate genes involved in CDP-choline, CDP-ethanolamine pathways that enhance phospholipid synthesis in S. constricta, potentially representing an adaptive mechanism to low-salinity environments. Notably, we found the lack of Cav2 member of caveolin family in euryhaline clams, which involved in Caveolae formation promoted by phospholipid. These findings enriched our understanding of the adaptive mechanisms and taxonomic characteristics of intertidal bivalves.</p>","PeriodicalId":18204,"journal":{"name":"Marine environmental research","volume":"211 ","pages":"107467"},"PeriodicalIF":3.2,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144959145","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of chlorpyrifos on growth and community structure of diatoms and dinoflagellates in the Bohai Sea, China.","authors":"Xiaoru Cui, Mengxue Xing, Limin Wang, Jing Zhao, Xiulin Wang, Keqiang Li","doi":"10.1016/j.marenvres.2025.107475","DOIUrl":"10.1016/j.marenvres.2025.107475","url":null,"abstract":"<p><p>The diatom/dinoflagellate ratio in the Bohai Sea is influenced by various environmental factors, potentially including the increasing input of agricultural pesticides. This study investigated the effects of chlorpyrifos (CPF) on phytoplankton growth and community structure through field-based culture experiments. The results showed that at a concentration of 30.0 μg L^-1 CPF had a stimulatory effect on algal growth, whereas a concentration of 50.0 μg L^-1 exhibited an inhibitory effect under low-temperature conditions (<24.0 °C). Continuous low-dose exposure to CPF prolonged and amplified the phytoplankton growth plateau. CPF exposure also drove a shift in the phytoplankton community structure from diatom-dominated to dinoflagellate-dominated, with Prorocentrum minimum and Karenia mikimotoi emerging as dominant species. Kinetic analysis revealed that CPF's impact on phytoplankton growth was primarily regulated by nitrogen uptake rates. These findings supplement and clarify a potential regime shift from diatom to dinoflagellate dominance associated with CPF in the Bohai Sea. Future coastal management strategies should account for the ecological risks of residual insecticides to ensure ecosystem stability.</p>","PeriodicalId":18204,"journal":{"name":"Marine environmental research","volume":"211 ","pages":"107475"},"PeriodicalIF":3.2,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144959638","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mortality risk and burden associated with non-optimum temperatures in Puerto Rico.","authors":"Francisco Díaz-Collado, Lingzhi Chu, Daniel Carrión, Pablo A Méndez-Lázaro, Kai Chen","doi":"10.1088/1748-9326/ae013e","DOIUrl":"10.1088/1748-9326/ae013e","url":null,"abstract":"<p><p>The effects of a changing climate are already evident in Caribbean small island developing states (SIDS) like Puerto Rico, where heat episodes have become more frequent. Despite reports of increasing heat-related death rates, robust epidemiological evidence on the health impacts of high temperatures, as well as the effects of low temperatures, remains scarce, particularly outside of urban settlements in Caribbean SIDS. In this study, we conducted a case time-series study on municipality-level mortality and temperature in Puerto Rico from 2015-2023. We modeled the relationship between daily mortality count and mean temperature using a conditional quasi-Poisson regression, combined with a distributed lag non-linear model (dlnm) with a 21 d lag, adjusting for relative humidity, seasonality, and day of the week. We estimated the minimum mortality temperature (MMT)-the optimal temperature associated with the lowest mortality risk-and calculated the relative risk associated with extreme low and high temperature, defined as the 2.5th and 97.5th percentiles of daily temperature. Additionally, we estimated the municipality- and island-level excess mortality fractions attributable to both low and high temperatures, relative to MMT. Our findings indicate that exposure to non-optimum temperatures (both low and high temperatures) is significantly associated with increased mortality risk. Specifically, extreme low temperature was associated with a 1.23 (95% CI: 1.07-1.40) times risk of all-cause mortality, while extreme high temperature was associated with a 1.16 (95% CI: 1.05-1.27) times risk. We estimated that temperature-related mortality accounted for 3.88% of the total 280 568 deaths (95% eCI: 3.39%-4.29%), with low temperatures contributing 2.02% (95% eCI: 1.69%-2.32%) and high temperatures contributing 1.86% (95% eCI: 1.35%-2.35%). Furthermore, we found substantial spatial variability in temperature-related mortality burdens across municipalities. Our study identifies the vulnerable municipalities to temperature-related deaths in Puerto Rico, providing evidence to inform municipality-specific climate adaptation and mitigation strategies.</p>","PeriodicalId":11747,"journal":{"name":"Environmental Research Letters","volume":"20 10","pages":"104032"},"PeriodicalIF":5.6,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12419553/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145039333","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A mobile gamma-ray LaBr₃(Ce) detector unit for in-situ radionuclide analysis at TENORM contamination sites.","authors":"F van Niekerk, P Jones, S Woodborne, R Newman","doi":"10.1016/j.jenvrad.2025.107767","DOIUrl":"10.1016/j.jenvrad.2025.107767","url":null,"abstract":"<p><p>Gamma-ray spectrometry, primarily utilising NaI(Tl) detectors, is widely used to measure naturally occurring radionuclides in terrestrial environments, but the use of LaBr₃(Ce) detectors is gaining prominence. Traditionally limited to vehicle-based deployments, access to hostile sites with elevated radiation has been restricted. This study demonstrates the effectiveness of a mobile radiation detection unit (MRDU) equipped with a LaBr₃(Ce) detector in such environments. The uranium Minimum Detectable Activity was 236 (16) Bq/kg at 1764.5 keV. The MRDU was deployed at the Welverdiend Agricultural Holdings, where elevated uranium levels are expected due to historic gold mining activities in the area., and the uranium activity was measured at 6477 Bq/kg. The uranium disequilibrium was investigated by comparing gamma radiation results with the total uranium concentration obtained through chemical analysis. The comparison confirmed the presence of uranium disequilibrium.</p>","PeriodicalId":15667,"journal":{"name":"Journal of environmental radioactivity","volume":"289 ","pages":"107767"},"PeriodicalIF":2.1,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144804240","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Experimental assessment of the combined exposure to methylmercury and nutritional stress on multiple reproductive endpoints on female zebrafish (Danio rerio).","authors":"Telmo Portugal-Baranda, Maren Ortiz-Zarragoitia, Jabi Zabala","doi":"10.1016/j.aquatox.2025.107520","DOIUrl":"10.1016/j.aquatox.2025.107520","url":null,"abstract":"<p><p>Wildlife is exposed to contaminants in their environment and also to other stressors such as cold or low food availability. The consequences of exposure to some contaminants and stressors have been studied to some detail in laboratory conditions but mostly exposing wildlife to a single stressor, while the consequences of combined exposure to contaminants and other stressor remain mostly unexplored. We exposed 228 adult zebrafish to a sublethal dose of methylmercury (MeHg), a globally distributed contaminant, and food restriction, probably the most common environmental stressor, in four treatment groups: control, MeHg (5 ppm through diet), food reduction (25 % of control food mass) and the combination of MeHg and food reduction. Our hypothesis was that combined exposure will produce synergistic (interactive) effects different and more severe than the mere addition of the individual effects. We exposed fish for 43-day sublethal exposure, and allowed them three reproductive attempts, whose success we measured using seven reproductive endpoints. We assessed each endpoint with five competitive models: No effect; MeHg effect; food restriction effect; MeHg and food restriction additive effect; and MeHg and food restriction interactive effect. In six of the seven endpoints the evidence contained in the results supported the interactive effect, strongly supporting our hypothesis. In the remaining one, no effects was observed in any group. However, contrary to our expectation, the combined exposure treatment group produced more viable offspring than any other. We currently have no explanation for that result and argue that combined exposure might have triggered life history trade-offs. Further research on the longer term and assessing carry-over and inter-generational effects could improve our understanding of the consequences of combined exposure to MeHg and food restriction.</p>","PeriodicalId":248,"journal":{"name":"Aquatic Toxicology","volume":"287 ","pages":"107520"},"PeriodicalIF":4.3,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144803037","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Semicarbazide conferred developmental toxicity in Oryzias melastigma embryos by oxidative stress and energy metabolism disorder.","authors":"Qiaoyue Xu, Chunqing Liu, Si Chen, Xishan Li, Deqi Xiong","doi":"10.1016/j.aquatox.2025.107531","DOIUrl":"10.1016/j.aquatox.2025.107531","url":null,"abstract":"<p><p>The residual antibiotics in aquatic animals present potential risk to ecological environment and food safety. Here, we uncover the biochemical reaction and molecular mechanisms in marine medaka embryos exposed to semicarbazide (SEM) at environmental relevant concentrations (10, 50 and 100 μg/L) for 14 days then followed by 7 days clean water recovery period. The decreased levels total superoxide dismutase (T-SOD) and catalase (CAT), and increased levels in malondialdehyde (MDA) content suggesting SEM induced severe oxidative stress and excessive reactive oxygen species (ROS). These effects further contributed to morphological changes and cardiac dysfunction. Meanwhile, oxidative stress activated genes associated with inflammatory responses (tlr1, cyp1a1, ahr, il-1β), implying potential suppression of innate immune functions. Furthermore, elevated activities of pyruvate kinase (PK), hexokinase (HK), and lactate dehydrogenase (LDH), along with decreased succinate dehydrogenase (SDH) activity, indicated SEM activate glycolysis pathway and disrupt Tricarboxylic Acid cycle (TCA) cycle leading to mitochondrial function and energy metabolism imbalance. Notably, these adverse effects cannot be completely eliminated after the short recovery period, implying a potential long-term toxicity of SEM. This study provides new insights into the toxicity effect SEM on the early developmental of marine organisms, its underlying regulatory mechanisms and implications for SEM risk management.</p>","PeriodicalId":248,"journal":{"name":"Aquatic Toxicology","volume":"287 ","pages":"107531"},"PeriodicalIF":4.3,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144803039","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}