环境科学与生态学最新文献_第4页

Microcystin-LR induces neuronal damage through mitophagy defects resulted from the downregulated transcription of Scd2 by directly targeting IGF-1R

IF 8.9 2区环境科学与生态学

Environmental Pollution Pub Date : 2024-12-25 DOI: 10.1016/j.envpol.2024.125589

Yao Tan, Yujing Huang, Weiyan Chen, Tingyuan Lang, Lingqiao Wang, Xiaoling Chen, Haili Yu, Zhiqun Qiu, Ke Cui, Chengwei Guo, Yiqi Wang, Ziyuan Zhou

{"title":"Microcystin-LR induces neuronal damage through mitophagy defects resulted from the downregulated transcription of Scd2 by directly targeting IGF-1R","authors":"Yao Tan, Yujing Huang, Weiyan Chen, Tingyuan Lang, Lingqiao Wang, Xiaoling Chen, Haili Yu, Zhiqun Qiu, Ke Cui, Chengwei Guo, Yiqi Wang, Ziyuan Zhou","doi":"10.1016/j.envpol.2024.125589","DOIUrl":"https://doi.org/10.1016/j.envpol.2024.125589","url":null,"abstract":"Microcystin-LR (MC-LR), a prevalent cyanotoxin present in hazardous cyanobacterial blooms, is recognized as a neurotoxic environmental pollutant that induces brain damage and neurobehavioral deficits. However, the mechanisms underlying MC-LR-induced neurotoxicity remain unclear. This study aims to elucidate the role of mitophagy in MC-LR-induced neurotoxicity both in vitro and in vivo. We found that administration of 10 μg/kg body weight (intraperitoneally) MC-LR impaired learning and memory abilities and induced neuronal damage and apoptosis in the CA1 region of the hippocampus in rats. Exposure to MC-LR (1 μM to 10 μM) resulted in cellular damage and apoptosis in PC-12 and HT22 cells. MC-LR induced mitophagy through the PINK1/Parkin pathway but hindered mitophagy progression by repressing Scd2 transcription in neurons. These inhibitory effects were reversed by Scd2 overexpression. Furthermore, MC-LR was found to repress Scd2 transcription by directly binding to type 1 insulin-like growth factor receptor (IGF-1R) and competitively inhibiting its activation by Insulin-like growth factor 1 (IGF-1). Overexpression of IGF-1R and administration of exogenous IGF-1 mitigated the MC-LR-induced inhibition of Scd2 and the associated mitophagy defects. These findings indicate that IGF-1R is the direct target of MC-LR in neurons. MC-LR initiates mitophagy defects and apoptosis by inhibiting Scd2 transcription through binding to IGF-1R.","PeriodicalId":311,"journal":{"name":"Environmental Pollution","volume":"14 1","pages":""},"PeriodicalIF":8.9,"publicationDate":"2024-12-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142884420","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Ocean as source or sink for legacy persistent organic pollutants

IF 13.6 1区环境科学与生态学

Journal of Hazardous Materials Pub Date : 2024-12-25 DOI: 10.1016/j.jhazmat.2024.136987

Chuchu Chen, Fen Yang, Qiang Wu, Jun Yu, Jingqian Xie, Yin Fang, Tian Lin

{"title":"Ocean as source or sink for legacy persistent organic pollutants","authors":"Chuchu Chen, Fen Yang, Qiang Wu, Jun Yu, Jingqian Xie, Yin Fang, Tian Lin","doi":"10.1016/j.jhazmat.2024.136987","DOIUrl":"https://doi.org/10.1016/j.jhazmat.2024.136987","url":null,"abstract":"With the phase-out of legacy persistent organic pollutants (POPs), the ocean’s role is evolving, potentially acting as both a reservoir and a source. This study investigates the air-sea fluxes of the first banned POPs, such as organochlorine pesticides (OCPs) and polychlorinated biphenyls (PCBs), using literature from Web of Science up to 2023. OCP and PCB concentrations in air and seawater show significant spatiotemporal variability. In air, α-HCH and p,p’-DDE dominate, with concentrations decreasing over time and varying with latitude. In seawater, α-HCH and p,p’-DDTs show higher levels in the Northern Hemisphere and significant temporal decreases. PCB concentrations differ notably between low- and high-chlorinated compounds, with distinct spatial patterns. HCHs exhibit distinct flux patterns, with volatilization in equatorial regions and deposition in higher latitudes. DDTs mainly show deposition trends, except in Southeast Asia where recent increases in volatilization are observed. PCBs generally demonstrate deposition, with regional and seasonal variations. Time significantly impacts fluxes due to changes in human activity and regulations. High-chlorine PCBs are more affected by distance from the sea surface, while temperature increases POPs volatilization.","PeriodicalId":361,"journal":{"name":"Journal of Hazardous Materials","volume":"54 1","pages":""},"PeriodicalIF":13.6,"publicationDate":"2024-12-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142884484","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Silent threats of lead-based paints in toys and households to children’s health and development

IF 13.6 1区环境科学与生态学

Journal of Hazardous Materials Pub Date : 2024-12-25 DOI: 10.1016/j.jhazmat.2024.136984

Muhammad Ubaid Ali, Muhammad Zeeshan Gulzar, Bisma Sattar, Sajeela Sehar, Qumber Abbas, Muhammad Adnan, Jingwei Sun, Zhuanxi Luo, Gongren Hu, Ruilian Yu, Ming Hung Wong

{"title":"Silent threats of lead-based paints in toys and households to children’s health and development","authors":"Muhammad Ubaid Ali, Muhammad Zeeshan Gulzar, Bisma Sattar, Sajeela Sehar, Qumber Abbas, Muhammad Adnan, Jingwei Sun, Zhuanxi Luo, Gongren Hu, Ruilian Yu, Ming Hung Wong","doi":"10.1016/j.jhazmat.2024.136984","DOIUrl":"https://doi.org/10.1016/j.jhazmat.2024.136984","url":null,"abstract":"Lead (Pb), a highly toxic heavy metal, poses a significant global health risk, particularly to children. Widely used in paint manufacturing for its remarkable corrosion-resistance properties Pb exposure has been linked to severe health issues, including reduced neurotransmitter levels, organ damage, potentially leading to death in extreme cases. Children Are particularly vulnerable, with Pb toxicity primarily affecting the brain, reproductive, kidneys, and cardiovascular systems. Approximately 0.6 million children worldwide suffer from cognitive impairments caused by Pb exposure. Despite varying Pb content regulations across countries, research has found that Pb concentration in paints often exceed permissible levels. A 0.01 mg/dL blood Pb level (BLL) is considered the threshold level as per the World Health Organization. However, recent studies reveal that significant health effects, including cognitive impairments in children, occur even at BLLs <0.01 mg/dL. This review provides critical insights into the global production and use of Pb-based paints, release mechanisms of Pb, exposure pathways, and safety standards. It also highlights the harmful effects of Pb on human health, particularly in children, and its detailed toxicity mechanisms. Finally, this review identifies critical knowledge gaps and offers perspectives for future research.","PeriodicalId":361,"journal":{"name":"Journal of Hazardous Materials","volume":"12 1","pages":""},"PeriodicalIF":13.6,"publicationDate":"2024-12-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142884485","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Reducing the molecular oxygen activation energy barrier by increasing Fe-O bonds to eliminate antibiotics and their resistance genes

IF 13.6 1区环境科学与生态学

Journal of Hazardous Materials Pub Date : 2024-12-25 DOI: 10.1016/j.jhazmat.2024.137008

Jieyi Pan, Yuxin Liu, Qintie Lin, Yirong Deng, Yang Luo, Zirui Zhao, Longyi Wei, Jianwen Huang, Jinguo Wang

{"title":"Reducing the molecular oxygen activation energy barrier by increasing Fe-O bonds to eliminate antibiotics and their resistance genes","authors":"Jieyi Pan, Yuxin Liu, Qintie Lin, Yirong Deng, Yang Luo, Zirui Zhao, Longyi Wei, Jianwen Huang, Jinguo Wang","doi":"10.1016/j.jhazmat.2024.137008","DOIUrl":"https://doi.org/10.1016/j.jhazmat.2024.137008","url":null,"abstract":"Sulfamethoxazole (SMX) and its antibiotic resistance genes (ARGs) are potential threats to public health. Microwave catalytic technology is an efficient environmental remediation technology, and a reasonable design of the catalyst enables the system to achieve an ideal remediation effect under low microwave power. In this study, a microwave catalyst (FeCO-2) that activates molecular oxygen (O2) was designed on the basis of rational theoretical organization. Density functional theory (DFT) calculations were used to predict the catalytic performance of FeCO-2 in the microwave field. The mechanism of active substance generation and successful construction of the MW/FeCO-2 catalytic system were verified by experimental studies. The abundance of Fe-O bonds alters the electronic structure of the iron carbide material (Fe@C), adjusts the conduction band potential of the material, reduces the reaction energy barrier, facilitates exciton dissociation under microwave, and facilitate O2 activation. The application of the MW/FeCO-2 system was verified with secondary effluent from a farm wastewater treatment process: 90.62% SMX and over 86.77% of ARGs were removed within 15 min. This study provides a new technique to efficiently simultaneously eliminate antibiotics and their resistance genes. In addition, this study provides ideas for the construction of a microwave catalytic system and explains the mechanism of the microwave catalytic process.","PeriodicalId":361,"journal":{"name":"Journal of Hazardous Materials","volume":"25 1","pages":""},"PeriodicalIF":13.6,"publicationDate":"2024-12-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142884513","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Machine Learning-powered Pseudo-target Screening of Emerging Contaminants in Water: A Case Study on Tetracyclines

IF 12.8 1区环境科学与生态学

Water Research Pub Date : 2024-12-25 DOI: 10.1016/j.watres.2024.123039

Ye Sun, Baoli Wu, Hongchao Dong, Jiaxuan Zhu, Nanqi Ren, Jun Ma, Shijie You

{"title":"Machine Learning-powered Pseudo-target Screening of Emerging Contaminants in Water: A Case Study on Tetracyclines","authors":"Ye Sun, Baoli Wu, Hongchao Dong, Jiaxuan Zhu, Nanqi Ren, Jun Ma, Shijie You","doi":"10.1016/j.watres.2024.123039","DOIUrl":"https://doi.org/10.1016/j.watres.2024.123039","url":null,"abstract":"Identifying emerging contaminants (ECs) in complex water environment is one of the greatest challenges. Target screening (TS) is limited by the lack of reference standards, whereas non-target screening (NTS) is subject to complex and unreliable data processing. In this study, we reported the machine learning (ML)-powered pseudo-target screening (PTS) for primary identification of ECs with tetracyclines (TCs) serving as model. Based on mass spectrometry (MS) data collected from MassBank database, we performed data purification by removing interferential peaks through optimizing the threshold factor (P=1%), the parameter that reflected intensity of interferential peaks (A) in relative to that of maximum peak (Amax). Then, the well-trained XGBoost model was obtained for correct identification of TCs and Non-TCs with probability approaching 100% by feeding experimental MS data with integrated peak- and test-related features. We for the first time demonstrated the effectiveness of such feature integration strategy for improving accuracy, reliability and anti-interference ability offered by the ML models. The XGBoost model could also identify the TCs that were in the both presence and absence of model training set, suggesting potential generalizability for identifying the unregulated and unknown ECs. Compared with previously reported TS and NTS, our ML-powered PTS framework offered an efficient, simple and reliable alternative to identifying ECs in environmental samples without the need for prior knowledge. This study not only has important implications for dealing with accidental emergency of water pollution relevant to occurrence of ECs, but also represents paradigm shift to develop AI-powered algorithm frameworks for identifying more ECs beyond tested TCs herein.","PeriodicalId":443,"journal":{"name":"Water Research","volume":"25 1","pages":""},"PeriodicalIF":12.8,"publicationDate":"2024-12-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142884648","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Deciphering the N1-Substituent Effects on Biodegradation of Sulfonamides: Novel Insights revealed from Molecular Biology and Computational Chemistry Approaches

IF 12.8 1区环境科学与生态学

Water Research Pub Date : 2024-12-25 DOI: 10.1016/j.watres.2024.123037

Jiahui Hu, Ruiyang Li, Jiayu Zhang, Lijia Cao, Huaxin Lei, Renxin Zhao, Lin Lin, Xiao-yan Li, Wen Zhang, Bing Li

{"title":"Deciphering the N1-Substituent Effects on Biodegradation of Sulfonamides: Novel Insights revealed from Molecular Biology and Computational Chemistry Approaches","authors":"Jiahui Hu, Ruiyang Li, Jiayu Zhang, Lijia Cao, Huaxin Lei, Renxin Zhao, Lin Lin, Xiao-yan Li, Wen Zhang, Bing Li","doi":"10.1016/j.watres.2024.123037","DOIUrl":"https://doi.org/10.1016/j.watres.2024.123037","url":null,"abstract":"Elucidating biodegradation mechanisms and predicting pollutant reactivities are essential for advancing the application of biodegradation engineering to address the challenge of thousands of emerging contaminants. Molecular biology and computational chemistry are powerful tools for this purpose, enabling the investigation of biochemical reactions at both the gene and atomic levels. This study employs the biodegradation of ten sulfonamide antibiotics as a case study to demonstrate the integration of genomics and quantum chemistry approaches in exploring the biodegradation behavior of emerging contaminants. The isolated functional strain, Paenarthrobacter sp., could completely degrade all ten model sulfonamides under aerobic conditions. These compounds share a 4-aminobenzenesulfonamide core but differ in N1-substituent rings. Despite structural variations, all sulfonamides followed a consistent degradation pathway, yielding aminated heterocycles as end products. This pathway involves key steps such as dehydrogenation activation, ipso-hydroxylation, and the cleavage of S-N and S-C bonds, with the latter being particularly influenced by the N1-substituents. Heterocyclic structures affect biodegradation rates by altering the electronic density at the C3 and N1 atoms of sulfonamides. Substituents with higher electron-donating potential and lower Gibbs free energy barriers for S-C and C-N bond cleavage significantly enhance biodegradation efficiency. This work not only deciphers the universal biodegradation mechanism of sulfonamides but also offers theoretical insights for predicting the biodegradation behavior and pattern of emerging contaminants. These findings contribute to the effective removal of emerging contaminants from aquatic environments, advancing the practical application of biotreatment technologies.","PeriodicalId":443,"journal":{"name":"Water Research","volume":"132 1","pages":""},"PeriodicalIF":12.8,"publicationDate":"2024-12-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142884654","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

An Integrated Approach of Carbon Footprint Calculation for Agricultural Sector through Smart-Farming

IF 11.1 1区环境科学与生态学

Journal of Cleaner Production Pub Date : 2024-12-25 DOI: 10.1016/j.jclepro.2024.144556

Dimitrios E. Tsesmelis, Ippokratis Gkotsis, Christos Saltogiannis, Spyridon Reppas, Stavros Panagakis, Efthimios Zervas

{"title":"An Integrated Approach of Carbon Footprint Calculation for Agricultural Sector through Smart-Farming","authors":"Dimitrios E. Tsesmelis, Ippokratis Gkotsis, Christos Saltogiannis, Spyridon Reppas, Stavros Panagakis, Efthimios Zervas","doi":"10.1016/j.jclepro.2024.144556","DOIUrl":"https://doi.org/10.1016/j.jclepro.2024.144556","url":null,"abstract":"Agricultural production and, by extension, the agri-food sector, significantly contribute to the greenhouse effect, as farming practices and inputs are among the main sources of greenhouse gas emissions (GHG). However, through the Smart Farming approach and the equipment and tools it entails, the reduction of the crops’ carbon footprint becomes increasingly feasible, and this is what the current study supports and aims to highlight. Therefore, the carbon footprint of three of the most important agricultural products in the Mediterranean (Olive, Orange and Grape) is examined in crops that have been supported by Smart Farming equipment and models, in order to compare the results with those of respective ones that follow conventional farming methods. The Life Cycle Analysis (LCA) tool (ISO 14040, 14044 and 14067) along with the most suitable emissions factors are employed to ensure the validity pf the process. The results reveal a carbon footprint between 0.400 and 0.520 per kg of olive fruits grown through Smart Farming methods, between 0.180 and 0.290 for oranges and between 0.190 to 0.290 for grapes. On the other hand, conventional applications have presented an increased trend. These findings highlight the efficiency of Smart Farming in minimizing resource use and emissions, offering a pathway toward more sustainable agricultural practices.","PeriodicalId":349,"journal":{"name":"Journal of Cleaner Production","volume":"25 1","pages":""},"PeriodicalIF":11.1,"publicationDate":"2024-12-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142884431","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Assessing recycled polyvinyl chloride reinforced modified asphalt mixtures for sustainable paving applications

IF 11.1 1区环境科学与生态学

Journal of Cleaner Production Pub Date : 2024-12-25 DOI: 10.1016/j.jclepro.2024.144583

Ali F. Al-Shawabkeh, Mohammad T. Awwad, Ibrahim I. Ikhries, Ziad S. Abu-Hamatteh, Nijad A. Al-Najdawi

引用次数: 0

Effects of naturally aged microplastics on arsenic and cadmium accumulation in lettuce: Insights into rhizosphere microecology

IF 13.6 1区环境科学与生态学

Journal of Hazardous Materials Pub Date : 2024-12-25 DOI: 10.1016/j.jhazmat.2024.136988

Yanwei Liu, Bingqian Li, Juanjuan Zhou, Dongqin Li, Yuanyang Liu, Yan Wang, Weigang Huang, Zhepu Ruan, Jun Yao, Rongliang Qiu, Guikui Chen

{"title":"Effects of naturally aged microplastics on arsenic and cadmium accumulation in lettuce: Insights into rhizosphere microecology","authors":"Yanwei Liu, Bingqian Li, Juanjuan Zhou, Dongqin Li, Yuanyang Liu, Yan Wang, Weigang Huang, Zhepu Ruan, Jun Yao, Rongliang Qiu, Guikui Chen","doi":"10.1016/j.jhazmat.2024.136988","DOIUrl":"https://doi.org/10.1016/j.jhazmat.2024.136988","url":null,"abstract":"Naturally aged microplastics (NAMPs) are commonly found in farmland soils contaminated with heavy metals (HMs), such as arsenic (As) and cadmium (Cd); yet their combined effects on soil–plant ecosystems remain poorly understood. In this study, we investigated the toxic effects of NAMPs and As–Cd on lettuce, considering the influence of earthworm activity, and examined changes in As–Cd bioavailability in the rhizosphere. Four experimental systems were established: soil–only, soil–lettuce, soil–earthworms, and soil–lettuce–earthworms systems, with four NAMPs concentrations (0, 0.1, 0.5, 1%). Our results showed that exposure to 0.1% NAMPs reduced As accumulation in lettuce shoots (0.17–0.25 mg kg−1) and roots (1.13–1.72 mg kg−1), while increasing biomass and enhancing root growth by alleviating toxicity. In contrast, the combined stress of higher NAMPs concentration (0.5%/1%) and As–Cd caused a 28.4–58.4% reduction in root activity, which stimulated low-molecular-weight organic acid (LMWOA) secretion in the rhizosphere, increasing the bioavailability of As and Cd and enhancing their absorption by lettuce. Partial least squares path modeling (PLS-PM) revealed that co-exposure altered LMWOA content, soil enzyme activity, and microbial community stability in the rhizosphere, ultimately influencing the bioavailability and uptake of As and Cd by lettuce.","PeriodicalId":361,"journal":{"name":"Journal of Hazardous Materials","volume":"65 1","pages":""},"PeriodicalIF":13.6,"publicationDate":"2024-12-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142884483","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Mitochondrial Mechanism of Florfenicol-induced Nonalcoholic Fatty Liver Disease in Zebrafish Using Multi-omics Technology

IF 13.6 1区环境科学与生态学

Journal of Hazardous Materials Pub Date : 2024-12-25 DOI: 10.1016/j.jhazmat.2024.136958

Lin Zhang, Yang Du, Yameng Li, Tiancai Wang, Yecan Pan, Xiaofeng Xue, Xiyan Mu, Jing Qiu, Yongzhong Qian

{"title":"Mitochondrial Mechanism of Florfenicol-induced Nonalcoholic Fatty Liver Disease in Zebrafish Using Multi-omics Technology","authors":"Lin Zhang, Yang Du, Yameng Li, Tiancai Wang, Yecan Pan, Xiaofeng Xue, Xiyan Mu, Jing Qiu, Yongzhong Qian","doi":"10.1016/j.jhazmat.2024.136958","DOIUrl":"https://doi.org/10.1016/j.jhazmat.2024.136958","url":null,"abstract":"Florfenicol (FF), a third-generation chloramphenicol antibiotic widely used in food-producing animals, has become a “pseudopersistent” environmental contaminant, raising concerns about its potential ecological and human health impacts. However, its bioaccumulation behavior and hepatotoxic mechanisms remain poorly understood. This study aims to address these gaps with a 28-day exposure experiment in adult zebrafish at 0.05 and 0.5 mg/L FF. Multiomic analyses (metabolomics, lipidomics, and transcriptomics), combined with histological and mitochondrial function assessments, were employed. Higher bioaccumulation was observed at 0.05 mg/L, potentially due to metabolic saturation at higher concentrations. Histological analysis revealed significant hepatic steatosis (>5% steatosis area), indicative of moderate nonalcoholic fatty liver disease (NAFLD). Multiomic data demonstrated global dysregulation in energy metabolism, including marked alterations in lipids (accumulation of toxic sphingolipids, excessive fatty acids, and acylglycerol), amino acids, tricarboxylic acid cycle intermediates, and nucleotides. Crucially, mitochondrial dysfunction was identified as a central mechanism, with impaired respiratory chain activities, adenosine triphosphate depletion, elevated reactive oxygen species, and oxidative stress promoting NAFLD progression. These findings highlight mitochondrial impairment and oxidative stress as key drivers of FF-induced hepatotoxicity, providing novel insights into its toxicological mechanisms and emphasizing the ecological risks posed by antibiotic pollution in aquatic systems.","PeriodicalId":361,"journal":{"name":"Journal of Hazardous Materials","volume":"24 1","pages":""},"PeriodicalIF":13.6,"publicationDate":"2024-12-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142884507","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0