Neuropsychology最新文献

{"title":"Everyday executive functions in children with neurofibromatosis type 1: Data from nine institutions.","authors":"Xiaoli Zong, Dan Liu, Xian Wu, Pamela L Wolters, Jonathan M Payne, Bonita P Klein-Tasman, Karin S Walsh, Jennifer Janusz, Natalie Pride, Stephanie M Morris, Carrie E Bearden, Peter L Stavinoha, Yang Hou","doi":"10.1037/neu0001087","DOIUrl":"10.1037/neu0001087","url":null,"abstract":"<p><strong>Objective: </strong>Executive function (EF) difficulties are prevalent in neurogenetic syndromes such as Neurofibromatosis Type 1 (NF1), the most common autosomal dominant condition associated with nervous system tumors. However, age-related differences in EF problems in children with NF1 remain poorly understood. This study aimed to examine how EF problems in daily life vary across ages throughout childhood and adolescence and how these age patterns vary across demographic and NF1 disease-related characteristics.</p><p><strong>Method: </strong>This study integrated data of 1,294 observations from 1,025 children with NF1 (<i>M</i>_age = 9.77 years, <i>SD</i> = 4.06, range = 3-18) from nine institutions in the United States and Australia. EF was reported by parents using the Behavior Rating Inventory of Executive Function. Time-varying effect modeling was used to estimate curvilinear EF trends.</p><p><strong>Results: </strong>Children with NF1 demonstrated elevated EF problems compared to the normative mean from early childhood through late adolescence, with deviations generally largest from midchildhood through midadolescence. At ages showing the greatest deviations from the normative mean, medium to large EF gaps were observed across five core domains (Cohen's <i>d</i> = 0.73-1.42). The exact age patterns varied across EF domains and by children's sex, parental education, and NF1 inheritance.</p><p><strong>Conclusions: </strong>Leveraging the largest EF data set of children with NF1 to date, this study precisely estimated EF problems across developmental periods and highlighted the heterogeneity in EF age patterns. These age-specific estimates are crucial for establishing EF developmental norms that guide clinical practice and patient management strategies. The findings can inform the design of individualized intervention and prevention strategies tailored to various developmental periods and diverse demographic and disease-related characteristics for children with NF1. (PsycInfo Database Record (c) 2026 APA, all rights reserved).</p>","PeriodicalId":19205,"journal":{"name":"Neuropsychology","volume":" ","pages":"812-823"},"PeriodicalIF":2.9,"publicationDate":"2026-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13089308/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147699281","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Normative cognitive test performance and typical error patterns among American Indian older adults: The Strong Heart Study.","authors":"Astrid M Suchy-Dicey, Kristoffer Rhoads, Brian French, Dedra Buchwald, W T Longstreth","doi":"10.1037/neu0001093","DOIUrl":"10.1037/neu0001093","url":null,"abstract":"<p><strong>Objective: </strong>The Strong Heart Study, a large cohort of American Indians from three U.S. regions, collected standardized neuropsychological assessments from participants aged 65-95 years at two visits (2010-2019), with prior documentation of lower overall score distributions and higher prevalence of cognitive impairment and dementia. This report aims to define expected score ranges for impaired and unimpaired as well as typical error patterns across this multidomain battery.</p><p><strong>Method: </strong>Participants were assessed as cognitive unimpaired (normal) or impaired through case review by a panel of clinicians-experts. Cognitive test score distributions were summarized and regression-normalized by age, sex, education, baseline cognition, bilingual status, and depression.</p><p><strong>Results: </strong>The strongest determinants of variability explained in test scores were age, education, and baseline cognition; depression was also associated with some tests. Error patterns were similar between overall group and intact group. Subitem analyses suggested that some tasks did not contribute to overall scores because most participants either correctly or incorrectly responded to the item. Common item analyses between similar tests suggested that interference may change score interpretability for similar tasks when repeated on different tests.</p><p><strong>Conclusions: </strong>These data represent the best estimates of expected cognitive test performance for older American Indians and may be useful to clinicians and researchers hoping to contextualize individual performance for patients within this sociodemographic. These results suggest that more research is needed among other Tribal groups, other Indigenous peoples, other socioeconomic contexts, younger ages, and with longitudinal evaluation. (PsycInfo Database Record (c) 2026 APA, all rights reserved).</p>","PeriodicalId":19205,"journal":{"name":"Neuropsychology","volume":" ","pages":"838-851"},"PeriodicalIF":2.9,"publicationDate":"2026-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13271159/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148252217","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Advancing neuropsychology training: Insights and advice from a qualitative analysis in 102 brain-behavior experts.","authors":"Mackenzie J Stabile, Sarah Prieto, Jennifer K Hoots, Sara Vargas, John A Bellone, W Curt LaFrance, Ryan Van Patten","doi":"10.1037/neu0001116","DOIUrl":"10.1037/neu0001116","url":null,"abstract":"<p><strong>Objective: </strong>Neuropsychologists possess knowledge that could benefit trainees as they navigate important career decisions within their unique training pathways. This wisdom is typically passed down in an individual mentorship model wherein supervisors and advisors relay advice directly. While this model has advantages, trainees can benefit from a broader range of perspectives. This study addressed this gap by consolidating advice for trainees through analysis of open-ended interview responses from a diverse group of brain-behavior experts.</p><p><strong>Method: </strong>Participants were interviewees (<i>N</i> = 102) from the podcast Navigating Neuropsychology (<i>M</i>_age = 52, <i>SD</i> = 11, range = 32-87; 55% late-career, 28% mid-career, 15% early-career; 87% PhD and 8% MD). Participants were asked a standardized question: \"What is one bit of advice that you wish someone told you when you were training, or someone did tell you, that really made a difference?\" Responses were audio-recorded, transcribed, and analyzed. A preliminary codebook was developed through discussion among authors. Three coders independently analyzed transcripts and met periodically to arrive at consensus coding. Thematic analysis identified major themes and subthemes.</p><p><strong>Results: </strong>Four major themes were identified: (a) mentorship and networking, (b) core knowledge and skill acquisition, (c) personal growth, and (d) decision making.</p><p><strong>Conclusions: </strong>Results offer actionable guidance for trainees, mentors, and training programs to improve training in neuropsychology. The four major themes underscore the multifaceted nature of training in neuropsychology and emphasize the importance of both technical competence and personal development throughout one's career. This work contributes to ongoing efforts to modernize neuropsychology training and prepare trainees for successful and personally fulfilling careers. (PsycInfo Database Record (c) 2026 APA, all rights reserved).</p>","PeriodicalId":19205,"journal":{"name":"Neuropsychology","volume":" ","pages":"882-894"},"PeriodicalIF":2.9,"publicationDate":"2026-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148631020","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Integrity in six key brain regions predicts numeric working memory performance in 30,000 middle-aged and older adults: A UK Biobank magnetic resonance imaging study.","authors":"Sarah Ellen Carnemolla, Tanmoy Debnath, Md Geaur Rahman, Minh Chau","doi":"10.1037/neu0001096","DOIUrl":"10.1037/neu0001096","url":null,"abstract":"<p><strong>Objective: </strong>This study investigated the neuroanatomical correlates of working memory using the UK Biobank Numeric Memory Test (NMT; a visual backward digit-span task) in a large sample of middle-aged and older adults. Volumes of brain regions previously implicated in digit-span tasks were hypothesized to positively correlate with NMT performance; however, some differences were expected due to visual NMT format (e.g., reduced relevance for language regions). A secondary aim was to generate the first normative data set for the NMT.</p><p><strong>Method: </strong>As part of the UK Biobank study, 30,640 healthy adults aged 51-80 completed both NMT and brain magnetic resonance imaging. Linear fixed-effects modeling assessed whether brain volumes (25 regions of interest) could predict NMT performance after accounting for age, sex, education, and head size. Normative data were generated as percentile tables stratified by age/sex/education.</p><p><strong>Results: </strong>Linear fixed-effects modeling revealed that better NMT performance was predicted by larger volumes of total cerebellar cortex, bilateral superior temporal, bilateral insula, left inferior parietal, left hippocampus, and left lateral occipital (<i>p</i> range: <.001-.048), with a moderate effect size (<i>f</i>² = 0.072). Both linear fixed-effects and normative data revealed that NMT performance decreases with age but increases with education (both <i>p</i> < .001), with no discernible sex differences.</p><p><strong>Conclusions: </strong>The findings support the idea that greater neurostructural integrity correlates with better cognitive performance. While future multimodal longitudinal studies are needed to confirm structure-function associations and more diverse ethnic/socioeconomic groups are needed to improve generalizability, these findings could inform clinical decision making and targeted treatment for working memory dysfunction. (PsycInfo Database Record (c) 2026 APA, all rights reserved).</p>","PeriodicalId":19205,"journal":{"name":"Neuropsychology","volume":" ","pages":"791-811"},"PeriodicalIF":2.9,"publicationDate":"2026-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148278293","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of simulated hearing loss on cognitive task performance: A scoping review.","authors":"Meike Holdinga, Paul Merkus, Johannes C F Ket, Sophia E Kramer, Cas Smits","doi":"10.1037/neu0001111","DOIUrl":"10.1037/neu0001111","url":null,"abstract":"<p><strong>Objective: </strong>Hearing loss (HL) and cognitive decline often co-occur in older adults. Many cognitive tests are administered using spoken instructions or stimuli, potentially biasing test results. The current scoping review aimed to provide an overview of studies using simulated HL in cognitively healthy participants to investigate its isolated impact on cognitive test performance, uncover gaps in current research, and provide directions for future research.</p><p><strong>Method: </strong>A literature search (in OVID/Medline, Embase.com, Clarivate Analytics/Web of Science Core Collection, and EBSCO/APA PsycINFO) was performed for publications prior to February 19, 2026. All studies examining the effects of simulated HL on cognitive tests in cognitively healthy, normal hearing participants were included.</p><p><strong>Results: </strong>In total, 1,322 studies were identified, and 10 studies were eligible for inclusion. The studies included the Mini-Mental State Examination; the Forward, Backward, and Sequencing Digit Span; and the Arithmetic Task of the Wechsler Adult Intelligence Scale IV, the Listening Span, the Hopkins Verbal Learning Test-Revised, and the Wide-Range Assessment of Memory and Learning-II. The studies comprised different HL simulation approaches, mimicking loss of audibility and/or distortion or cochlear implant processing.</p><p><strong>Conclusions: </strong>Simulated HL is associated with decreased cognitive test performance. Further research is needed because knowledge about quantifying the effect of HL on specific cognitive tasks is lacking. Awareness of the effect of HL on test scores may facilitate more reliable interpretation of cognitive test results. (PsycInfo Database Record (c) 2026 APA, all rights reserved).</p>","PeriodicalId":19205,"journal":{"name":"Neuropsychology","volume":" ","pages":"852-865"},"PeriodicalIF":2.9,"publicationDate":"2026-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148631012","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sex-specific differences in amygdala resting-state functional connectivity with trait anxiety.","authors":"Aliesha M Kemp, Kyle T S Pattinson, Paul Glue, Bruce R Russell, Olivia K Harrison","doi":"10.1037/neu0001100","DOIUrl":"10.1037/neu0001100","url":null,"abstract":"<p><strong>Objective: </strong>Anxiety disorders are the most common mental health conditions in the world, disproportionately affecting females and associated with significant morbidity. Neuroimaging can help us to understand the underpinnings of anxiety behaviors. The amygdala and its subnuclei have been strongly implicated in the neural circuitry of anxiety, with widespread connectivity with regions involved in emotional regulation and fear responses. The aim of this study was to investigate differences in resting-state functional connectivity of the amygdala and its subregions with levels of trait anxiety in a nonclinical population, and how this may differ between males and females.</p><p><strong>Method: </strong>7 T resting-state functional magnetic resonance imaging scans from 40 individuals (50% female) and State-Trait Anxiety Inventory-Trait component scores were used with seed-based functional connectivity analyses.</p><p><strong>Results: </strong>There were no differences in State-Trait Anxiety Inventory-Trait component scores between males and females (mean score ± <i>SD</i>, 30.2 ± 6.3), with no differences in resting-state functional connectivity observed between the basolateral and centromedial (CMA) subregions. However, increases in resting-state functional connectivity were identified with greater levels of anxiety with bilateral amygdala (combined basolateral and CMA; <i>p</i> < .05) and CMA (<i>p</i> < .01). Exploratory (<i>p</i> < .05) sex differences in this connectivity profile were also observed, with widespread reduction in amygdala and CMA connectivity related to trait anxiety in females compared to males.</p><p><strong>Conclusion: </strong>These results contribute to our understanding of neural circuitry involved in anxiety and highlight the importance of further research into sex-specific differences in larger studies with clinical anxiety, given the disproportionate prevalence of anxiety disorders between males and females. (PsycInfo Database Record (c) 2026 APA, all rights reserved).</p>","PeriodicalId":19205,"journal":{"name":"Neuropsychology","volume":" ","pages":"866-881"},"PeriodicalIF":2.9,"publicationDate":"2026-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148164106","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The unity and diversity of executive functions across adulthood in a diverse Brazilian sample with varying educational attainment.","authors":"Sabine Pompeia, Tâmara P Taporoski, Isis Angélica Segura, Luz Marina Gómez, Hugo Cogo-Moreira, Andrea Roseli Vançan Russo Horimoto, Alexandre da Costa Pereira, Homero Vallada, André Brooking Negrão","doi":"10.1037/neu0001085","DOIUrl":"10.1037/neu0001085","url":null,"abstract":"<p><strong>Objective: </strong>Executive functions (EFs) are a set of cognitive abilities associated with many social and clinical outcomes that are believed to be sensitive to culture, age, and educational attainment. Yet, this was determined using EF theoretical models and tests developed for highly educated young adults, so it may not apply to more diverse samples.</p><p><strong>Method: </strong>A community sample from Brazil (Baependi Heart Study cohort: <i>N</i> = 1,253; 753 females), in which age (18-88 years) and schooling (0-23 years) varied widely, was assessed based on a popular theoretical model of EF (the unity and diversity EF framework), which describes the pattern of interassociations of three specific types of EFs (inhibition, shifting, and updating). To this end, we employed a short, nonautomated, open-access EF test battery adapted for use in samples with varying ages and educational attainment that included EF indicators obtained from three tasks (Plus-Minus, Trail Making, and Random Number Generation tasks).</p><p><strong>Results: </strong>Using confirmatory factor analyses, we found a good-fitting three-correlated factor solution confirming the fractionation and interassociation of the three EF domains, which was invariant (except for one of eight indicators) to age, schooling, and sex. More years of schooling were related to higher latent traits in all domains and older age to worse shifting, and women scored lower in latent shifting and inhibition.</p><p><strong>Conclusions: </strong>The unity-diversity EF framework can be determined across adulthood in diverse samples with tasks adapted for these populations. Building upon our findings may expand a theory-oriented investigation of sociocultural, demographic, and clinical factors that influence EFs. (PsycInfo Database Record (c) 2026 APA, all rights reserved).</p>","PeriodicalId":19205,"journal":{"name":"Neuropsychology","volume":" ","pages":"824-837"},"PeriodicalIF":2.9,"publicationDate":"2026-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147699299","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"An examination of the relation between early childhood lead (Pb) exposure and cognitive intraindividual variability in a medicolegal sample.","authors":"Bailey N Wagaman, Sydney Sullivan, Vasilios C Ikonomou, Stephen L Aita, Nicholas C Borgogna, Joshua S Kline, Michael P Santa Maria, Benjamin D Hill","doi":"10.1037/neu0001130","DOIUrl":"https://doi.org/10.1037/neu0001130","url":null,"abstract":"<p><strong>Objective: </strong>Lead (Pb) exposure, particularly during early childhood, is a major health concern associated with diminished cognitive performance. Most prior research has focused on Full-Scale IQ (FSIQ). This study examined relations between childhood blood Pb exposure and cognitive intraindividual variability (IIV) in a medicolegal sample.</p><p><strong>Method: </strong>Two-hundred sixteen adolescent participants (50% female; 82.4% Black; age <i>M</i> = 20.47, <i>SD</i> = 2.05 years; education <i>M</i> = 10.94, SD = 1.56 years) completed a neuropsychological battery more than a decade after documented Pb exposure. All participants passed the Test of Memory Malingering or Word Memory Test. IIV was operationalized as an examinee's performance dispersion across a battery of nine test scores (IIV dispersion). Continuous Performance Test-Second Edition Variability also served as an index of IIV inconsistency (within-task reaction time variability). Associations among blood Pb exposure, IIV metrics, and FSIQ were examined using bivariate correlations, group comparisons, and multiple regression.</p><p><strong>Results: </strong>IIV dispersion was positively correlated with childhood average blood Pb (<i>r</i> = .17-.22) and the average of the highest three Pb values (<i>r</i> = .20-.25) and negatively correlated with FSIQ (<i>r</i> = -.32 to -.55). FSIQ was unrelated to Pb outcomes. Demographic and psychiatric factors were unrelated to Pb and IIV variables. Within-group analyses revealed a dose-response pattern, with the high Pb group showing greater IIV-dispersion metrics than the low and medium exposure groups (<i>d</i> = |0.38| to |0.50|). Regression analyses indicated that IIV-dispersion metrics predicted Pb exposure above-and-beyond FSIQ and IIV inconsistency.</p><p><strong>Conclusions: </strong>These results support that cognitive IIV, particularly dispersion-based indices, is a sensitive marker of Pb-related neurocognitive dysfunction, providing incremental information beyond FSIQ and IIV inconsistency. (PsycInfo Database Record (c) 2026 APA, all rights reserved).</p>","PeriodicalId":19205,"journal":{"name":"Neuropsychology","volume":" ","pages":""},"PeriodicalIF":2.9,"publicationDate":"2026-10-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149195259","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Retrieval-induced forgetting and facilitation across the Alzheimer's disease continuum: Behavioral and neuroanatomical evidence from a recognition-based paradigm.","authors":"Carlotta Di Domenico, Sabrina Bonarota, Giulia Caruso, Sofia Sperati, Francesco Di Lorenzo, Marta Rodini, Carlo Caltagirone, Giacomo Koch, Federico Giove, Marco Bozzali, Laura Serra","doi":"10.1037/neu0001126","DOIUrl":"https://doi.org/10.1037/neu0001126","url":null,"abstract":"<p><strong>Objective: </strong>The aim of the present study was to investigate facilitation (FAC) and retrieval-induced forgetting (RIF) during episodic memory retrieval across the Alzheimer's disease (AD) continuum and to examine their gray matter correlates in verbal and visual recognition tasks.</p><p><strong>Method: </strong>One hundred participants (28 AD, 29 amnestic mild cognitive impairment, 23 subjective cognitive decline [SCD], 20 healthy subjects) completed a modified retrieval-practice paradigm (mRPP) involving verbal and visual recognition tasks, a comprehensive neuropsychological battery, and 3T magnetic resonance imaging. FAC and RIF were computed at the group level and via individual proxy scores, and voxel-based morphometry was used to assess the association between mRPP indices and regional gray matter volumes.</p><p><strong>Results: </strong>The verbal mRPP showed reduced overall recognition in AD compared with healthy subjects (<i>p</i> = .003 - η_p² = 0.23). A robust FAC effect in AD, amnestic mild cognitive impairment, and SCD was observed, whereas RIF emerged only in SCD, suggesting intact inhibitory control at the earliest stage and its disruption with disease progression (<i>p</i> < .001 - η_p² = 0.48). The visual mRPP showed a strong FAC effect across all groups, with no RIF, indicating modality-specific reliance on recognition-based retrieval (<i>p</i> < .001 - η_p² = 0.63). Voxel-based morphometry analyses revealed distinct gray matter correlates across groups and tasks: Verbal RIF was negatively associated with frontotemporal regions in AD patients and parieto-occipital regions in healthy subjects, while visual indices showed widespread associations with temporal, subcortical, cerebellar, and sensorimotor regions, particularly in amnestic mild cognitive impairment and SCD groups.</p><p><strong>Conclusions: </strong>This study shows shared and modality-specific brain mechanisms of retrieval practice across AD stages. Preserved compensatory processes in SCD individuals give way to progressive regional disruption, supporting early, modality-tailored, and multimodal cognitive interventions to enhance cognition and delay cognitive decline. (PsycInfo Database Record (c) 2026 APA, all rights reserved).</p>","PeriodicalId":19205,"journal":{"name":"Neuropsychology","volume":" ","pages":""},"PeriodicalIF":2.9,"publicationDate":"2026-10-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149195309","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Motor intrusion errors as a novel marker of neurodegeneration and executive dysfunction in Alzheimer's disease.","authors":"Cierra M Keith, Holly E Phelps, Samantha R Smith, Camila Vieira Ligo Teixeira, Rashi I Mehta, Patrick Worhunsky, Melanie Ward, Joseph Malone, Lauren Bojarski, Gary Marano, Khalid Sharif, Stephanie Pockl, Nafiisah Rajabalee, Pierre-François D'Haese, Ali Rezai, Marc W Haut","doi":"10.1037/neu0001132","DOIUrl":"https://doi.org/10.1037/neu0001132","url":null,"abstract":"<p><p><b><i>Objective:</i></b> With the development of disease-modifying therapies for Alzheimer's disease, continued clarification of clinical indicators of disease progression is needed. Based on prior observations of motor intrusion errors in amyloid-positive individuals, we sought to characterize differences in clinical, cognitive, and neuroimaging variables between amyloid-positive participants with and without motor intrusions. <b><i>Method:</i></b> We examined 284 amyloid-positive participants with mild cognitive impairment or mild dementia evaluated within a multidisciplinary memory clinic setting. Participants with and without motor intrusion errors were compared across neuropsychological performance variables while controlling for demographic, clinical, and neuroimaging factors. <b><i>Results:</i></b> Participants with motor intrusion errors demonstrated indicators of more progressed disease on clinical and neuroimaging markers. After controlling for these variables, greater executive dysfunction was observed in participants with motor intrusions with effect sizes ranging from small (η_p² = .02) to medium (η_p² = .12). Differences in performances on memory, naming, and basic processing speed tasks were not observed between the groups. <b><i>Conclusions:</i></b> Overall, the results of the present study suggest that the presence of a motor intrusion error may be associated with greater clinical impairment and, more specifically, executive dysfunction in Alzheimer's disease. (PsycInfo Database Record (c) 2026 APA, all rights reserved).</p>","PeriodicalId":19205,"journal":{"name":"Neuropsychology","volume":" ","pages":""},"PeriodicalIF":2.9,"publicationDate":"2026-10-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149183335","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}