Neuropsychology最新文献

{"title":"Joint effects of human immunodeficiency virus (HIV) and cannabis on neurocognition.","authors":"Ashley R Adams, Sarah M Lehman, Erin L Thompson, Christine M Kaiver, Diego Lopez, Samuel W Hawes, Brenda Lerner, Catalina Lopez-Quintero, Raul Gonzalez","doi":"10.1037/neu0001003","DOIUrl":"https://doi.org/10.1037/neu0001003","url":null,"abstract":"<p><strong>Objective: </strong>Cannabis has become increasingly accessible to populations living with chronic health conditions such as HIV. Many people living with HIV are turning to cannabis for symptom relief despite the unclear risks to neurocognitive health. Our study sought to replicate and extend prior research by examining global and domain-specific neurocognitive performance between four groups stratified by use of cannabis (CB; CB+/CB-) and HIV serostatus (HIV+/HIV-).</p><p><strong>Method: </strong>Our demographically diverse community sample (<i>N</i> = 269) underwent exclusion and inclusion criteria to isolate the effects of cannabis use (CU) and HIV on neurocognition. We explored between-group comparisons of neurocognitive performance, probability of neurocognitive impairment, and interactive effects of CU/HIV serostatus.</p><p><strong>Results: </strong>Between-group comparisons revealed nonsignificant differences in global or domain-specific neurocognitive performance. However, the CB+/HIV+ group was three times (99% CI [1.18, 9.57]) more likely to be labeled with a memory impairment compared to the control (CB-/HIV-), and the CB+/HIV- group was twice (99% CI [.14, 7.47]) as likely to be labeled with an executive functioning impairment compared to the control. We also identified an interactive effect between the past 30-day CU and HIV serostatus for global (<i>b</i> = -.026, 99% CI [-.04, -.01]) and motor (<i>b</i> = -.052, 99% CI [-.07, -.03]) neurocognitive performance. Findings support a nuanced relationship between CU and HIV, which may partly explain mixed literature.</p><p><strong>Conclusions: </strong>Although we conclude that recent and heavy CU poses risk of neurocognitive decline among people living with HIVs, this effect is modest. Physicians and patients must weigh a possible decrease in global and motor neurocognition against the severity of symptoms being treated. (PsycInfo Database Record (c) 2025 APA, all rights reserved).</p>","PeriodicalId":19205,"journal":{"name":"Neuropsychology","volume":" ","pages":""},"PeriodicalIF":2.6,"publicationDate":"2025-07-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144675361","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The classification accuracy of the recognition memory test-words as a performance validity test is affected by gender and education.","authors":"Laszlo A Erdodi","doi":"10.1037/neu0001027","DOIUrl":"https://doi.org/10.1037/neu0001027","url":null,"abstract":"<p><strong>Objective: </strong>Previous research suggested that Recognition Memory Test-Words (RMT-W) scores may be confounded by gender and handedness. This study was designed to examine its classification accuracy as a performance validity test (PVT) and susceptibility to demographic characteristics.</p><p><strong>Method: </strong>Archival data were collected from a consecutive sequence of 310 diagnostically heterogeneous examinees (181 men; <i>M</i>_Age = 41.4; <i>M</i>_Education = 12.9). The RMT-W's classification accuracy was computed against psychometrically operationalized criterion groups.</p><p><strong>Results: </strong>Optimal RMT-W cutoffs (≤ 42 to ≤ 40) produced a good combination of sensitivity (.62-.70) and specificity (.90-.96), correctly classifying 85.6%-87.7% of the sample. Women scored 1.5 points higher. RMT-W scores were unrelated to handedness but were correlated with education. A linear relationship emerged between level of education and the cutoff needed to achieve ≥ .90 specificity: ≤ 43 for ≥ 13 years of education, ≤ 41 for 12 years of education, and ≤ 39 for ≤ 11 years of education. RMT-W ≤ 45 had .91 specificity in women with postsecondary education.</p><p><strong>Conclusions: </strong>Results suggest that overall, the RMT-W remains an effective free-standing PVT. Gender, age, and handedness in isolation had minimal impact on RMT-W scores. However, education had a clinically significant effect. The combined effect of gender and education produced a marked shift in classification accuracy. Systematic research is needed on the relationship between demographics and PVT outcomes to ensure that cutoffs have the same clinical interpretation regardless of patient variables. (PsycInfo Database Record (c) 2025 APA, all rights reserved).</p>","PeriodicalId":19205,"journal":{"name":"Neuropsychology","volume":" ","pages":""},"PeriodicalIF":2.6,"publicationDate":"2025-07-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144560628","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Monolinguals outperform bilinguals in language but not executive function in aging and cognitive impairment.","authors":"Stefanie Gard, Joseph Saad, Christine L Sheppard, Vanessa Taler","doi":"10.1037/neu0001028","DOIUrl":"https://doi.org/10.1037/neu0001028","url":null,"abstract":"<p><strong>Objective: </strong>People with subjective cognitive decline (SCD) self-report declining cognitive function, although objective cognitive performance remains normal. SCD is a risk factor for mild cognitive impairment (MCI) and dementia. Previous research has found differences in cognitive performance in bilinguals compared with monolinguals. We examined cognitive performance in older adults with and without SCD, and the association between bilingualism and cognitive performance in cognitively healthy older adults, people with SCD, and people with MCI, and the influence of bilingualism on the age of MCI diagnosis.</p><p><strong>Method: </strong>Adults aged 65+ (<i>n</i> = 264) rated their ability in French and English and self-perceived change in concentration and attention, memory, and word-finding. They then completed neuropsychological tests assessing language, memory, and executive function. Participants were monolingual or bilingual and were older adults, reported amnestic or nonamnestic SCD, or had MCI.</p><p><strong>Results: </strong>No differences in cognitive performance were observed between older adults and people with SCD, while people with MCI had lower performance on nearly all tasks. Monolinguals outperformed bilinguals in the Boston Naming Test, letter-number sequencing, California Verbal Learning Test, FAS, animal, vegetable/musical instrument, and A/F switch fluency tasks, but group performance did not differ on executive function tasks. Sensitivity analyses using English L1 bilinguals who completed the first administration of the language tasks in the English or bilingual version showed that monolinguals outperformed bilinguals on only the Boston Naming Test. Monolinguals had a later age of MCI diagnosis than bilinguals in our sample.</p><p><strong>Conclusions: </strong>These findings suggest that the protective effect of bilingualism reported elsewhere in the literature is not universal. (PsycInfo Database Record (c) 2025 APA, all rights reserved).</p>","PeriodicalId":19205,"journal":{"name":"Neuropsychology","volume":" ","pages":""},"PeriodicalIF":2.6,"publicationDate":"2025-07-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144560614","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Concurrent validity, test-retest reliability, and normative properties of the ignite app: A cognitive assessment for frontotemporal dementia.","authors":"Rhian S Convery, Kerala Adams-Carr, Jennifer M Nicholas, Katrina M Moore, Sophie Goldsmith, Martina Bocchetta, Lucy L Russell, Jonathan D Rohrer","doi":"10.1037/neu0001005","DOIUrl":"10.1037/neu0001005","url":null,"abstract":"<p><strong>Objective: </strong>Digital biomarkers can provide frequent, real-time monitoring of health-related behavior and could play an important role in the assessment of cognition in frontotemporal dementia (FTD). However, the validity and reliability of digital biomarkers as measures of cognitive function must first be determined.</p><p><strong>Method: </strong>The Ignite cognitive app contains iPad-based measures of executive function, social cognition, and other domains affected in FTD. Here we describe the normative properties of the Ignite tests, evaluate associations with gold-standard neuropsychological tests, and investigate test-retest reliability through two healthy control studies. Over 2,000 cognitively normal adults aged 20-80 years were recruited to complete the Ignite app remotely. A separate cohort of 98 healthy controls completed Ignite at two timepoints (7 days apart), a pen and paper neuropsychology battery, and a User Experience Questionnaire.</p><p><strong>Results: </strong>Significant associations were found between age and performance on several Ignite measures of processing speed (<i>r</i> = 0.42-0.56, <i>p</i> < .001) and executive function (<i>r</i> = 0.43-0.62, <i>p</i> < .001). With the exception of one test (Time Tap), the Ignite tests demonstrated moderate to excellent test-retest reliability (intraclass correlation coefficients [ICC] = 0.54-0.92) and significant correlations with their pen and paper counterparts (<i>r</i> = 0.25-0.72, <i>p</i> < .05). The majority of participants (> 90%) rated the app favorably, stating it was enjoyable and easy to complete unsupervised.</p><p><strong>Conclusions: </strong>These findings offer early support for the validity of the Ignite tests suggesting they measure the intended cognitive processes, capture a stable picture of performance over time, and are well accepted in healthy controls. This work supports the feasibility of administering the app remotely and its potential utility as a cognitive tool in FTD; however, validation is ongoing, and further work is required before Ignite can be used as an endpoint in clinical trials. (PsycInfo Database Record (c) 2025 APA, all rights reserved).</p>","PeriodicalId":19205,"journal":{"name":"Neuropsychology","volume":" ","pages":"402-421"},"PeriodicalIF":2.6,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143803769","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Resting-state intrinsic network connectivity and mind wandering: Insights from tasks with varying demands.","authors":"Hong He, Yunyun Chen, Xuemin Zhang","doi":"10.1037/neu0001017","DOIUrl":"10.1037/neu0001017","url":null,"abstract":"<p><strong>Objective: </strong>Recent research has uncovered that mind wandering, as evaluated through a mind wandering questionnaire, is linked to heightened functional connectivity within the default mode network (DMN) and increased functional connectivity between the DMN and the frontoparietal control network (FPCN). However, limited research has focused on the association between mind wandering and resting-state network functional connectivity in relation to task demands.</p><p><strong>Method: </strong>This study aimed to address this issue by collecting data on resting-state functional magnetic resonance imaging images and mind wandering during 0-back and 1-back tasks outside the scanner (<i>N</i> = 93). The study examined how resting-state functional connectivity within and between intrinsic brain networks (DMN, FPCN, and dorsal attention network) is associated with mind wandering during tasks of different cognitive loads.</p><p><strong>Results: </strong>The results of the study revealed a significant positive correlation between mind wandering and resting-state within-network connectivity of the DMN in both tasks. Additionally, in the 0-back task, mind wandering exhibited a significant positive correlation with resting-state connectivity between the DMN and the FPCN. In the 1-back task, mind wandering demonstrated a significant positive correlation with resting-state connectivity between the DMN and the dorsal attention network.</p><p><strong>Conclusions: </strong>These findings are consistent with previous findings and further suggest that the relationship between resting-state network functional connectivity and mind wandering is sensitive to task demands. They lend support to the context regulation hypothesis, suggesting that executive function may regulate mind wandering frequency based on situational demands. (PsycInfo Database Record (c) 2025 APA, all rights reserved).</p>","PeriodicalId":19205,"journal":{"name":"Neuropsychology","volume":" ","pages":"450-462"},"PeriodicalIF":2.6,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143974846","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cold executive functions moderate the relationship between hot executive function and externalizing behavior in adolescents and adults.","authors":"Olivia Choy","doi":"10.1037/neu0001007","DOIUrl":"10.1037/neu0001007","url":null,"abstract":"<p><strong>Objective: </strong>Although deficits in executive functions (EFs) have been shown to characterize individuals who exhibit externalizing behavior problems, few studies have differentiated between the influence of hot and cold EF on externalizing behavior. This study tests whether there is an interaction between performance on assessments of cold and hot EF in relation to externalizing behavior in a community sample of adolescents and adults.</p><p><strong>Method: </strong>Analyses were conducted on 396 adolescents (<i>M</i>_age = 14.81 years) and 393 of their parents (<i>M</i>_age = 45.39 years). Cold and hot EFs were assessed in both groups using a battery of neuropsychological tests, alongside externalizing behavior in both adolescents and their parents using a variety of self-report and parent-report questionnaires.</p><p><strong>Results: </strong>A significant Hot EF × Cold EF interaction was found in both samples, such that adolescents and adults with increased risk taking on a hot EF task, but higher cold EF scores exhibited lower levels of externalizing behavior. Adults with reduced performance on both hot and cold EF tasks exhibited the highest levels of externalizing behavior.</p><p><strong>Conclusions: </strong>Both hot and cold EFs contribute to the propensity for externalizing behavior. Results show that in the presence of increased risky decision making, which is a domain of hot EF, higher cold EF acts as a protective factor against externalizing behavior. Notably, this is observed in both adolescents and adults. Findings point to the possibility of targeting deficits in cold EF in interventions to reduce externalizing behavior. (PsycInfo Database Record (c) 2025 APA, all rights reserved).</p>","PeriodicalId":19205,"journal":{"name":"Neuropsychology","volume":" ","pages":"463-471"},"PeriodicalIF":2.6,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12162207/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143542689","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Predictors of cognitive performance in Zambian adults with clade C HIV-1: The roles of antiretroviral therapy (ART)-induced CD4+ T-cell increase and pulmonary tuberculosis.","authors":"Knut A Hestad, J Anitha Menon, Mary Shilalukey Ngoma, Lumbuka Kaunda, Norma Kabuba, Ravi Paul, Scott Letendre, Donald R Franklin, Robert K Heaton","doi":"10.1037/neu0001000","DOIUrl":"10.1037/neu0001000","url":null,"abstract":"<p><strong>Objective: </strong>In this cross-sectional study in Zambia, we examined factors that influence cognitive performance in adults with clade C human immunodeficiency virus-1 (HIV) infection who were on antiretroviral therapy.</p><p><strong>Method: </strong>We examined if detectable HIV ribonucleic acid (RNA) in blood plasma, nadir CD4+ T-cell count before antiretroviral therapy, increase in CD4+ T-cell count during antiretroviral therapy, and having pulmonary tuberculosis (TB) influenced cognitive performance. We performed a multilinear regression in which the dependent variable was the global mean cognitive <i>T</i>-score, an overall composite score based on 16 neuropsychological tests that were adjusted for age, sex, and education using normative data from Zambian adults without HIV infection. The 16 tests were merged into seven cognitive domains: Executive Functions, Verbal Fluency, Attention/Working Memory, Learning (immediate recall), Memory (delayed recall), Motor Control, and Speed of Information Processing.</p><p><strong>Results: </strong>When on antiretroviral therapy, a greater increase in CD4+ T-cells was significantly associated with a better global mean cognitive <i>T</i>-score (<i>p</i> = .002). Pulmonary TB was independently associated with worse performance (<i>p</i> = .008). Neither nadir CD4+ T-cell count nor plasma HIV RNA during antiretroviral therapy was associated with cognitive performance.</p><p><strong>Conclusions: </strong>Accounting for CD4+ T-cell increase after antiretroviral therapy initiation and comorbid pulmonary TB may help explain cognitive outcomes in persons with HIV infection in endemic settings. We suggest that it is essential that those with a low CD4+ T-cell count increase the number of cells as early as possible. Our data suggest that this is important for their cognitive functioning. Future research should determine whether the deleterious effect of pulmonary TB resolves after completion of TB treatment. (PsycInfo Database Record (c) 2025 APA, all rights reserved).</p>","PeriodicalId":19205,"journal":{"name":"Neuropsychology","volume":" ","pages":"375-383"},"PeriodicalIF":2.6,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144033600","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impaired decision-making ability in functional heartburn patients.","authors":"Yue Li, Jingjing He, Lulu Zeng, Hui Hu, Qiao Wang, Yanghua Tian, Lijiu Zhang, Xiangpeng Hu","doi":"10.1037/neu0000999","DOIUrl":"10.1037/neu0000999","url":null,"abstract":"<p><strong>Objective: </strong>Rats with visceral hypersensitivity often exhibit impaired decision-making abilities. Functional heartburn (FH) is a functional esophageal disease that belongs to the category of gut-brain interaction disorders, associated with visceral hypersensitivity. However, the decision-making ability of patients with FH remains unclear.</p><p><strong>Method: </strong>We recruited 30 patients diagnosed with FH based on the Rome IV criteria and 30 healthy controls (HCs). All patients were evaluated using the Hamilton Anxiety Scale and the 17-item Hamilton Depression Scale-17. Patients with FH also completed the gastroesophageal reflux disease and modified gastrointestinal symptom score questionnaires. We employed the Iowa Gambling Task (IGT) and Game of Dice Task (GDT) to evaluate decision making.</p><p><strong>Results: </strong>In the IGT, patients with FH exhibited a lower total net score and made more unfavorable choices compared to healthy controls (HCs). Specifically, statistically significant differences were observed in the net scores of the last three blocks, the differences were of large effect sizes. In the GDT, patients with FH demonstrated a lower total net score, higher risk score, and lower utilization of negative feedback than the HCs, the differences were of middle-large effect sizes. Even after controlling for the effects of anxiety, depression, and the coexistence of functional dyspepsia, patients with FH exhibited lower net scores than HCs, in both the IGT and GDTs.</p><p><strong>Conclusions: </strong>Our findings suggest that patients with FH showed worse decision-making abilities than HCs. (PsycInfo Database Record (c) 2025 APA, all rights reserved).</p>","PeriodicalId":19205,"journal":{"name":"Neuropsychology","volume":" ","pages":"422-431"},"PeriodicalIF":2.6,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143523637","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Contributions of the hippocampus and prefrontal cortex to the spacing effect: Evidence from lesioned patients.","authors":"Cuihong Li, Qi Liu, Ke Sun, Tao Yu, Xiaotong Fan, Jiangfei Wang, Liankun Ren, Jiongjiong Yang","doi":"10.1037/neu0001009","DOIUrl":"10.1037/neu0001009","url":null,"abstract":"<p><strong>Objective: </strong>Although the hippocampus is critical for memory processes, recent studies have suggested that amnesic patients with hippocampal lesions can still acquire some types of memory by distributed learning rather than by massed learning. However, as these studies recruited patients with developmental amnesia, whether lesion onset influenced the spacing effect was unclear. In addition, the extent to which the prefrontal cortex (PFC) supports the spacing effect has not been explored.</p><p><strong>Method: </strong>Patients with hippocampal lesions at early onset and late onset and PFC lesions were enrolled. The participants learned face-scene pairs under single learning (i.e., once in 1 day), massed learning (i.e., four times in 1 day), and distributed learning (i.e., four times in 2 days, twice per day). Then, they performed associative recognition tasks 20 min and 1 day later.</p><p><strong>Results: </strong>The results showed that the spacing effect was significantly higher than baseline (<i>d</i> = 2.91) and comparable with the control groups for hippocampal lesions at early onset patients at 1 day. However, the spacing effect was significantly impaired for hippocampal lesions at late onset (<i>d</i> = -1.84) and PFC patients (<i>d</i> = -1.48) when compared with the normal groups. The repetition effect (massed vs. single learning) was significantly impaired for PFC patients at 20 min when compared with the controls (<i>d</i> = -1.15).</p><p><strong>Conclusions: </strong>These findings clarified the roles of the hippocampus and PFC in distributed learning and repetitive learning and suggest that early-onset hippocampal damage induces a significant reorganization in the human brain to support memory formation and retention. (PsycInfo Database Record (c) 2025 APA, all rights reserved).</p>","PeriodicalId":19205,"journal":{"name":"Neuropsychology","volume":" ","pages":"432-449"},"PeriodicalIF":2.6,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143803774","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sleep fragmentation, 24-hr rest-activity patterns, and cognitive function in premanifest Huntington's disease: An actigraphy study.","authors":"Emily S Fitzgerald, Yifat Glikmann-Johnston, Jessica E Manousakis, Meg Rankin, Clare Anderson, Melinda L Jackson, Julie C Stout","doi":"10.1037/neu0001001","DOIUrl":"10.1037/neu0001001","url":null,"abstract":"<p><strong>Objective: </strong>In Huntington's disease (HD), cognitive symptoms, sleep fragmentation, and daily activity pattern alterations can occur up to 15 years before diagnosis in premanifest HD (Pre-HD). Whether sleep and rest-activity patterns relate to cognitive function in Pre-HD, however, remains unclear. We investigated the relationships between rest-activity patterns, sleep, and cognitive function in Pre-HD compared to healthy controls (HCs).</p><p><strong>Method: </strong>All participants completed 14 days of actigraphy, online questionnaires, and remote cognitive assessments.</p><p><strong>Results: </strong>The Pre-HD group (<i>n</i> = 36) performed worse on Speeded Tapping than the HC group (<i>n</i> = 42). Pre-HD participants with heightened sleep fragmentation performed more poorly on the Trail Making Test (TMT) and Hopkins Verbal Learning Test-Revised (HVLT-R). In Pre-HD, lower intra-daily variability and higher interdaily stability (more stable, less fragmented rest-activity patterns) were associated with poorer performance on the trail making test Part B, Symbol Digit Modalities Test, Emotion Recognition Task, Rey Complex Figure Test, visual memory task, paced tapping, and HVLT-R total trial. Higher interdaily stability was also linked to poorer HVLT-R performance. Relative amplitude and sleep regularity index were not related to performance. Poorer sleep quality on the Pittsburgh Sleep Quality Index correlated with worse HVLT-R delayed and paced tapping scores. More severe insomnia (higher Insomnia Severity Index scores) correlated with lower Rey Complex Figure Test copy.</p><p><strong>Conclusions: </strong>Our findings emphasize the importance of uninterrupted sleep on cognitive function in Pre-HD and reveal targets for interventions aimed at improving cognitive symptoms. Larger cohorts stratified by proximity to diagnosis are critical to improving our understanding of these relationships across the premanifest period. (PsycInfo Database Record (c) 2025 APA, all rights reserved).</p>","PeriodicalId":19205,"journal":{"name":"Neuropsychology","volume":" ","pages":"384-401"},"PeriodicalIF":2.6,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143542655","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}