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Measurement differences in the Harmonized Cognitive Assessment Protocol across ethnicity and language in the United States. 美国跨种族和语言的统一认知评估协议的测量差异。
IF 3 3区 心理学
Neuropsychology Pub Date : 2026-05-01 Epub Date: 2026-02-09 DOI: 10.1037/neu0001059
Emily M Briceño, Lewis B Morgenstern, Zachary J Kunicki, Deborah A Levine, Roshanak Mehdipanah, Nelda Garcia, Wen Chang, Xavier F Gonzales, Bruno Giordani, Steven G Heeringa, Darin B Zahuranec, Kenneth M Langa, Richard N Jones
{"title":"Measurement differences in the Harmonized Cognitive Assessment Protocol across ethnicity and language in the United States.","authors":"Emily M Briceño, Lewis B Morgenstern, Zachary J Kunicki, Deborah A Levine, Roshanak Mehdipanah, Nelda Garcia, Wen Chang, Xavier F Gonzales, Bruno Giordani, Steven G Heeringa, Darin B Zahuranec, Kenneth M Langa, Richard N Jones","doi":"10.1037/neu0001059","DOIUrl":"10.1037/neu0001059","url":null,"abstract":"<p><strong>Objectives: </strong>The Harmonized Cognitive Assessment Protocol (HCAP) is a neuropsychological assessment for dementia that is used to derive national dementia prevalence estimates through a substudy of the Health and Retirement Study. We aimed to evaluate the degree of measurement invariance of the HCAP across Hispanic/Latino-a-e-x (H/L) and non-H/L white (NHW) older adults in the United Study.</p><p><strong>Method: </strong>We combined HCAP data from two large cohort studies. We used multiple-group confirmatory factor analysis to evaluate measurement invariance across H/L adults assessed in English (<i>n</i> = 259), H/L adults assessed in Spanish (<i>n</i> = 236), and NHW adults assessed in English (<i>n</i> = 2,462).</p><p><strong>Results: </strong>We observed measurement differences in the HCAP across H/L and NHW older adults for the memory, language, executive functioning, and orientation, but not visuospatial, domains. Effect sizes for measurement differences in HCAP items ranged from small to large. Not accounting for measurement differences led to meaningful underestimation of cognitive function ranging from 5% (language domain) to 82% (executive functioning domain) of H/L individuals assessed in English and 11% (memory domain) to 96% (executive functioning domain) of H/L individuals assessed in Spanish.</p><p><strong>Conclusions: </strong>The interpretation of ethnic differences in cognitive function with the HCAP may be confounded with measurement differences. Measurement equivalence in cognitive assessment instruments across H/L and NHW populations cannot be assumed. (PsycInfo Database Record (c) 2026 APA, all rights reserved).</p>","PeriodicalId":19205,"journal":{"name":"Neuropsychology","volume":" ","pages":"387-401"},"PeriodicalIF":3.0,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12888800/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146142448","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The association between positive childhood experiences and executive function among Chinese adolescents. 中国青少年积极童年经历与执行功能的关系。
IF 3 3区 心理学
Neuropsychology Pub Date : 2026-05-01 Epub Date: 2026-03-26 DOI: 10.1037/neu0001076
Shengyu Luo, Xiuqiong Feng, Lu Li, Zhongzhi Xu, Weiqing Chen, Dan Xu, Vivian Yawei Guo
{"title":"The association between positive childhood experiences and executive function among Chinese adolescents.","authors":"Shengyu Luo, Xiuqiong Feng, Lu Li, Zhongzhi Xu, Weiqing Chen, Dan Xu, Vivian Yawei Guo","doi":"10.1037/neu0001076","DOIUrl":"10.1037/neu0001076","url":null,"abstract":"<p><strong>Objective: </strong>Positive childhood experiences (PCEs) have been linked to adolescent health, but less is known about their association with executive function or the unique contributions of specific PCEs. This study aimed to examine the association between individual PCEs and adolescent executive function and to explore whether these associations differed by maltreatment experiences.</p><p><strong>Method: </strong>This cross-sectional study included 4,789 high school students (<i>M</i><sub>age</sub>: 14.0 years, 53.9% boys) in Guangzhou, China. Adolescents self-reported their PCEs, executive function, and maltreatment experiences using the Benevolent Childhood Experiences Scale, the Adolescent Executive Function Scale, and the Adverse Childhood Experiences International Questionnaire, respectively. Structural equation modeling was applied to estimate the association of individual PCEs with latent executive function domains. Multiple-group structural equation modeling was used to examine whether the associations differed by maltreatment experiences.</p><p><strong>Results: </strong>Three latent executive function domains were identified, including inhibitory control, cognitive flexibility, and working memory. Among the individual PCEs, positive self-perception, a predictable home routine, and enjoyment of school showed the largest standardized coefficients across all executive function domains. In multiple-group structural equation modeling analyses, none of the structural paths from PCEs to executive function domains significantly differed between adolescents with and without maltreatment experiences, indicating comparable associations across maltreatment subgroups.</p><p><strong>Conclusions: </strong>Our findings revealed complex associations between PCEs and adolescent executive function, underscoring the importance of promoting multifaceted PCEs across self, family, and school contexts to support cognitive development for all adolescents, regardless of their maltreatment experiences. Nevertheless, future randomized controlled trials are warranted to confirm these conclusions. (PsycInfo Database Record (c) 2026 APA, all rights reserved).</p>","PeriodicalId":19205,"journal":{"name":"Neuropsychology","volume":" ","pages":"429-437"},"PeriodicalIF":3.0,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147513563","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Influence of testing language and aging on verbal list memory in deaf American Sign Language-English bilinguals. 测试语言和年龄对美国手语-英语双语聋人言语表记忆的影响。
IF 3 3区 心理学
Neuropsychology Pub Date : 2026-05-01 Epub Date: 2026-02-05 DOI: 10.1037/neu0001065
Sadie Camilliere, Karen Emmorey, Peter C Hauser, Jessica Contreras, Michael M McKee, Tamar H Gollan
{"title":"Influence of testing language and aging on verbal list memory in deaf American Sign Language-English bilinguals.","authors":"Sadie Camilliere, Karen Emmorey, Peter C Hauser, Jessica Contreras, Michael M McKee, Tamar H Gollan","doi":"10.1037/neu0001065","DOIUrl":"10.1037/neu0001065","url":null,"abstract":"<p><strong>Objective: </strong>The present study examined aging and testing-language effects on verbal list learning in young adult and older deaf bilinguals of American Sign Language (ASL) and written English. It is not known which language maximizes free recall, and no list learning task has been widely adopted for testing this population.</p><p><strong>Method: </strong>Thirty-two younger (aged 20-45) and 32 older (aged 64-84) deaf ASL-English bilinguals completed list memory tests in each language. Participants were shown videos of 10 ASL signs and 10 written English words one at a time for immediate recall across three learning trials and a delayed recall trial, with language of testing counterbalanced.</p><p><strong>Results: </strong>Younger participants showed no effect of language on recall, recalled more items than older participants in both languages, and had higher primacy scores on Trial 1. Older participants showed better learning when tested in English but higher rates of forgetting compared to when they were tested in ASL (a robust interaction between language and group with a medium-to-large effect size, η<sub>p</sub>² = 0.11). Both young and older participants forgot more items in whichever language was tested second. Though most deaf participants reported being more proficient in ASL, an equal number of deaf participants recalled more English than ASL list items as vice versa (i.e., more ASL items than English items).</p><p><strong>Conclusions: </strong>Use of both ASL and English lists maximizes different aspects of memory performance in older deaf participants, with English benefitting learning and ASL minimizing forgetting. However, a complete characterization of memory requires testing in both languages. (PsycInfo Database Record (c) 2026 APA, all rights reserved).</p>","PeriodicalId":19205,"journal":{"name":"Neuropsychology","volume":" ","pages":"402-417"},"PeriodicalIF":3.0,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12968385/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146125843","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The neural basis of reward magnitude, effort level, and subjective value: An activation likelihood estimation meta-analysis of effort-based reward tasks in healthy cohorts. 奖励大小、努力水平和主观价值的神经基础:健康人群中基于努力的奖励任务的激活似然估计meta分析。
IF 3 3区 心理学
Neuropsychology Pub Date : 2026-05-01 Epub Date: 2026-02-09 DOI: 10.1037/neu0001068
Hui Wang, Jia Huang, Simon S Y Lui, Raymond C K Chan
{"title":"The neural basis of reward magnitude, effort level, and subjective value: An activation likelihood estimation meta-analysis of effort-based reward tasks in healthy cohorts.","authors":"Hui Wang, Jia Huang, Simon S Y Lui, Raymond C K Chan","doi":"10.1037/neu0001068","DOIUrl":"10.1037/neu0001068","url":null,"abstract":"<p><strong>Objectives: </strong>Reward motivation refers to the willingness to expend effort in pursuit of reward, which is believed to be affected by reward magnitude, effort level, and subjective value, but its neural basis remains unclear. The present study aims to identify brain regions associated with reward magnitude, effort level, and subjective value in healthy people.</p><p><strong>Method: </strong>We performed an activation likelihood estimation meta-analysis. Moreover, we conducted meta-analytic connectivity modeling to examine the coactivation patterns associated with these regions.</p><p><strong>Results: </strong>Following the Preferred Reporting Items for Systematic reviews and Meta-Analyses guidelines and eligibility criteria, we included 33 task-based functional imaging studies with effort-based reward tasks. The activation likelihood estimation and meta-analytic connectivity modeling meta-analyses found that increased reward magnitude primarily elicited activation in the caudate head and putamen, with coactivation observed in the claustrum, insula, dorsal thalamus, and midbrain red nucleus. Moreover, elevated effort level predominantly engaged the medial frontal gyrus, showing coactivation with the insula and inferior frontal gyrus. Enhanced subjective value was chiefly associated with caudate head activation, coactivated with the thalamus, parahippocampal gyrus, and insula.</p><p><strong>Conclusion: </strong>Our findings provided a framework delineating the integrated insula-frontostriatal-thalamus network for the reward valuation system in healthy people. (PsycInfo Database Record (c) 2026 APA, all rights reserved).</p>","PeriodicalId":19205,"journal":{"name":"Neuropsychology","volume":" ","pages":"438-450"},"PeriodicalIF":3.0,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146142457","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Financial competence, situation, and context of people with recent-onset psychosis: A comparison with matched controls and the role of cognition. 新发精神病患者的经济能力、状况和背景:与匹配对照和认知作用的比较
IF 3 3区 心理学
Neuropsychology Pub Date : 2026-05-01 Epub Date: 2026-02-16 DOI: 10.1037/neu0001070
Josephien Leonie Jansen, Lydia Krabbendam, Oliver Tucha, Richard Bruggeman, Janneke Koerts
{"title":"Financial competence, situation, and context of people with recent-onset psychosis: A comparison with matched controls and the role of cognition.","authors":"Josephien Leonie Jansen, Lydia Krabbendam, Oliver Tucha, Richard Bruggeman, Janneke Koerts","doi":"10.1037/neu0001070","DOIUrl":"10.1037/neu0001070","url":null,"abstract":"<p><strong>Objective: </strong>People with a psychotic disorder often experience financial challenges. Financial competence problems might underlie these challenges, yet little is known about the extent and type of these problems, particularly in the recent-onset phase of psychosis. This study aimed to examine differences in financial competence between people with recent-onset psychosis and matched controls without psychosis. In addition, we assessed participants' financial situation and context. Last, we investigated cognitive functioning and its potential mediating role in group differences in financial competence.</p><p><strong>Method: </strong>Thirty-six people with recent-onset psychosis and 40 matched controls completed a comprehensive and standardized financial and cognitive test battery.</p><p><strong>Results: </strong>Compared to controls, people with recent-onset psychosis performed more poorly on most aspects of financial competence. They also reported less favorable outcomes in their financial situation and context. Mediation analyses did not support a robust mediating role of cognitive functioning in explaining group differences in financial competence.</p><p><strong>Conclusions: </strong>Problems in financial competence, as well as a less favorable financial situation and context, may already be present in the recent-onset phases of psychosis. These difficulties appear to be multifaceted and cannot be explained by cognitive functioning. These findings highlight the need for assessment tools that go beyond cognitive assessment and are specifically designed to evaluate everyday competences such as financial competence. Integrating such assessments into clinical practice could support timely recognition of problems in financial competence and more appropriate, tailored referrals to financial support services for people in the recent-onset phases of psychosis. (PsycInfo Database Record (c) 2026 APA, all rights reserved).</p>","PeriodicalId":19205,"journal":{"name":"Neuropsychology","volume":" ","pages":"329-343"},"PeriodicalIF":3.0,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146213793","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Examination of objective and subjective cognition and their association with functional outcomes: A cross-sectional study in a Canadian sample of homeless and precariously housed adults. 客观和主观认知的检验及其与功能结果的关联:加拿大无家可归和住房不稳定的成年人样本的横断面研究。
IF 3 3区 心理学
Neuropsychology Pub Date : 2026-05-01 Epub Date: 2026-02-16 DOI: 10.1037/neu0001077
Michelle J Blumberg, Caitlin M Terao, Suzanne Mckeag, Vicky Stergiopoulos, Stephen W Hwang, Kristina M Gicas
{"title":"Examination of objective and subjective cognition and their association with functional outcomes: A cross-sectional study in a Canadian sample of homeless and precariously housed adults.","authors":"Michelle J Blumberg, Caitlin M Terao, Suzanne Mckeag, Vicky Stergiopoulos, Stephen W Hwang, Kristina M Gicas","doi":"10.1037/neu0001077","DOIUrl":"10.1037/neu0001077","url":null,"abstract":"<p><strong>Objective: </strong>Using a cross-sectional design, our aim was to examine whether objective and subjective cognition differentially relate to everyday functioning and quality of life in homeless and precariously housed adults. As an exploratory aim, we examined whether associations between cognition and outcomes differ by age and gender.</p><p><strong>Method: </strong>Participants were 88 community-dwelling adults experiencing homelessness or precarious housing in Toronto, Canada. Participants completed measures of objective cognition, subjective cognition, quality of life, and perceived everyday functioning. Linear regressions explored associations between facets of cognition and domains of quality of life and perceived everyday functioning while accounting for covariates. Exploratory models examined interactions between cognition, gender, and age.</p><p><strong>Results: </strong>Objective cognition was not associated with the outcomes (all <i>p</i> > .05). Subjective cognition was positively associated with all domains of quality of life, physical health (<i>B</i> = 0.03, <i>p</i> < .001), psychological (<i>B</i> = 0.04, <i>p</i> < .001, social relationships, <i>B</i> = 0.02, <i>p</i> = .004), environment (<i>B</i> = 0.03, <i>p</i> = .004), and perceived everyday functioning (<i>B</i> = 0.02, <i>p</i> = .012). Gender moderated the association between objective cognition and social relationships, such that greater objective cognition was associated with greater quality of life in social relationships for men (<i>B</i> = 0.02, <i>p</i> = .047), but not women (<i>B</i> = -0.02, <i>p</i> = .091).</p><p><strong>Conclusions: </strong>Subjective cognitive measures should be included alongside objective measures to obtain a comprehensive understanding of the needs of homeless populations. Studies should include performance-based functional assessments to clarify the relationship between objective cognition, subjective cognition, and outcomes. (PsycInfo Database Record (c) 2026 APA, all rights reserved).</p>","PeriodicalId":19205,"journal":{"name":"Neuropsychology","volume":" ","pages":"344-358"},"PeriodicalIF":3.0,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146213802","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Network analyses of cognitive performance in psychiatric disorders: A scoping review. 精神疾病认知表现的网络分析:范围综述。
IF 3 3区 心理学
Neuropsychology Pub Date : 2026-05-01 Epub Date: 2025-12-11 DOI: 10.1037/neu0001062
Mathias Hasse-Sousa, Pedro Henrique Minotto Serafim, Letícia Sanguinetti Czepielewski
{"title":"Network analyses of cognitive performance in psychiatric disorders: A scoping review.","authors":"Mathias Hasse-Sousa, Pedro Henrique Minotto Serafim, Letícia Sanguinetti Czepielewski","doi":"10.1037/neu0001062","DOIUrl":"10.1037/neu0001062","url":null,"abstract":"<p><strong>Objective: </strong>Cognitive dysfunction is a transdiagnostic feature of psychiatric disorders and a major contributor to functional and psychosocial disability. Despite its clinical importance, the structure and dynamics of cognitive dysfunction across psychiatric conditions remain unclear. Network analysis offers a promising framework to conceptualize cognition not as isolated domains, but as interdependent systems of functions that dynamically interact with clinical symptoms and behavioral outcomes. This scoping review systematically mapped and synthesized 59 empirical studies applying network analysis to cognition across psychiatric disorders, including schizophrenia, major depression, bipolar disorder, and others.</p><p><strong>Method: </strong>Following Preferred Reporting Items for Systematic Reviews and Meta-Analyses Extension for Scoping Reviews guidelines, we extracted and synthesized data on sample characteristics, cognitive assessments, network models, and key findings.</p><p><strong>Results: </strong>Most studies employed undirected, cross-sectional Gaussian graphical models, while directed or longitudinal models remained rare. Fewer than half of the studies conducted inferential statistics, with the remainder relying on descriptive observations. Overlap between studies was weak for cognitive domains studied and very weak for cognitive instruments used. Most studies originated from Europe, followed by Asia and North America; no studies were conducted in Latin America or Africa. Across disorders, cognition typically emerged as a distinct yet highly interconnected domain within broader psychopathological networks. Processing speed and working memory were consistently featured as central nodes, particularly in schizophrenia, lending support to their role as foundational elements of cognition. However, substantial methodological heterogeneity and limited causal modeling challenges remain.</p><p><strong>Conclusions: </strong>Future research should emphasize theory-driven frameworks, longitudinal designs, standardized cognitive assessments, and replicability to better understand the role of cognition in psychiatric disorders. (PsycInfo Database Record (c) 2026 APA, all rights reserved).</p>","PeriodicalId":19205,"journal":{"name":"Neuropsychology","volume":" ","pages":"359-386"},"PeriodicalIF":3.0,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145743570","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Normative data and clinical validity of verb and phonemic fluency tasks in Turkish-speaking older adults. 土耳其语老年人动词和音位流畅性任务的规范性数据和临床有效性。
IF 3 3区 心理学
Neuropsychology Pub Date : 2026-05-01 Epub Date: 2026-04-06 DOI: 10.1037/neu0001089
Samet Tosun, Fenise Selin Karalı, Elif İkbal Eskioğlu, Derya Çavdar, Miray Dicle, Nilgün Çınar, Joel Macoir
{"title":"Normative data and clinical validity of verb and phonemic fluency tasks in Turkish-speaking older adults.","authors":"Samet Tosun, Fenise Selin Karalı, Elif İkbal Eskioğlu, Derya Çavdar, Miray Dicle, Nilgün Çınar, Joel Macoir","doi":"10.1037/neu0001089","DOIUrl":"10.1037/neu0001089","url":null,"abstract":"<p><strong>Objective: </strong>Verbal fluency tasks are commonly used in clinical neuropsychology to assess language and executive functions. Verb fluency and phonemic fluency are sensitive to age-related cognitive decline and neurodegenerative conditions such as mild cognitive impairment (MCI) and Alzheimer's disease (AD). However, normative data for these tasks remain limited in Turkish-speaking populations, especially when culturally adapted phonemic fluency measures are employed. This study aimed to (a) provide normative data for verb fluency and Turkish-adapted K-A-S phonemic fluency tasks in healthy middle-aged and older adults, and (b) examine the discriminant validity of these tasks in distinguishing healthy controls from individuals with MCI and AD.</p><p><strong>Method: </strong>In the normative phase, 357 healthy adults were assessed and stratified by age and education. Norms were reported as regression-based z scores and percentile tables.</p><p><strong>Results: </strong>In the clinical phase, 150 participants (50 healthy, 60 MCI, and 40 AD) completed the tasks. Kruskal-Wallis and post hoc analyses revealed significant group differences across all fluency measures. Healthy controls outperformed both clinical groups, and the MCI group scored higher than the AD group, especially on K fluency and total K-A-S scores.</p><p><strong>Conclusions: </strong>These findings highlight the diagnostic value of verb and phonemic fluency tasks and the importance of using culturally appropriate norms in Turkish-speaking populations for early detection of cognitive impairment. (PsycInfo Database Record (c) 2026 APA, all rights reserved).</p>","PeriodicalId":19205,"journal":{"name":"Neuropsychology","volume":" ","pages":"418-428"},"PeriodicalIF":3.0,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147623487","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Plasma biomarkers of neurodegeneration and intraindividual cognitive variability: Comparing variability across test at one time point and using repeated ecological momentary assessment. 神经退行性变和个体认知变异性的血浆生物标志物:比较一个时间点测试的变异性和使用重复的生态瞬间评估。
IF 3 3区 心理学
Neuropsychology Pub Date : 2026-04-27 DOI: 10.1037/neu0001080
Luciana Mascarenhas Fonseca, Doug L Weeks, Michael Cleveland, Zoë W Hawks, Lanee Jung, Yogish C Kudva, Shafaq Rizvi, Jane Bulger, Elizabeth Grinspoon, Kamille Janess, Martin Sliwinski, Richard E Pratley, Michael R Rickels, Ruth S Weinstock, Jasmeer P Chhatwal, Pia Webb Kivisäkk, Michal Schnaider Beeri, Laura Thi Germine, Naomi Sage Chaytor
{"title":"Plasma biomarkers of neurodegeneration and intraindividual cognitive variability: Comparing variability across test at one time point and using repeated ecological momentary assessment.","authors":"Luciana Mascarenhas Fonseca, Doug L Weeks, Michael Cleveland, Zoë W Hawks, Lanee Jung, Yogish C Kudva, Shafaq Rizvi, Jane Bulger, Elizabeth Grinspoon, Kamille Janess, Martin Sliwinski, Richard E Pratley, Michael R Rickels, Ruth S Weinstock, Jasmeer P Chhatwal, Pia Webb Kivisäkk, Michal Schnaider Beeri, Laura Thi Germine, Naomi Sage Chaytor","doi":"10.1037/neu0001080","DOIUrl":"https://doi.org/10.1037/neu0001080","url":null,"abstract":"<p><strong>Objective: </strong>Intraindividual cognitive variability (IICV) is a promising measure for early identification of dementia risk. Fewer studies have assessed IICV using high-frequency digital cognitive assessment or in populations with medical conditions. We aimed to characterize associations between IICV for reaction time and accuracy with plasma biomarkers of neurodegeneration (phosphorylated tau 181, phosphorylated tau 217, β-amyloid 42/40 ratio, glial fibrillary acidic protein, and neurofilament light chain) in individuals with Type 1 diabetes.</p><p><strong>Method: </strong>We analyzed data from 114 participants from the Glycemic Variability and Fluctuations in Cognitive Status in Adults With Type 1 Diabetes study who provided blood samples (<i>M</i> = 48.9 years, range = 19-84). Cognition was assessed digitally at baseline and three times daily for 15 days via ecological momentary assessment. Hierarchical linear regression models examined associations between biomarkers and IICV, adjusting for demographics, glycemic variability, mean cognition, and nephropathy. Multiple testing correction used Benjamini-Hochberg.</p><p><strong>Results: </strong>IICVs for reaction time at baseline and across repeated assessments were correlated and associated with β-amyloid 42/40, glial fibrillary acidic protein, neurofilament light chain, and phosphorylated tau 217 (small to moderate effect size, <i>p</i> < .05), but associations did not remain significant after adjustment. Exploratory analyses indicated interactions with age and sex. IICV for accuracy was not associated with any biomarker.</p><p><strong>Conclusions: </strong>Although associations between IICV and plasma biomarkers were not robust after full adjustment, exploratory analyses suggested potential interactions with age and sex. The sample was predominantly non-Hispanic White, limiting the generalizability of our findings. These findings support continued investigation of digital IICV as a dynamic marker of early cognitive vulnerability. (PsycInfo Database Record (c) 2026 APA, all rights reserved).</p>","PeriodicalId":19205,"journal":{"name":"Neuropsychology","volume":" ","pages":""},"PeriodicalIF":3.0,"publicationDate":"2026-04-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13124075/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147777261","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Promoting digital memory aid use in older adults with cognitive concerns: A pilot randomized controlled trial of adaptive web-based training. 促进有认知问题的老年人使用数字记忆辅助工具:适应性网络训练的随机对照试验。
IF 3 3区 心理学
Neuropsychology Pub Date : 2026-04-27 DOI: 10.1037/neu0001071
Maureen Schmitter-Edgecombe, Catherine Luna, Reanne Cunningham Chilton, Samina Rahman, Brooke F Beech, Xingzi Li, Maggie Dines, Shenghai Dai, Diane J Cook
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