Using the Modified Taylor Complex Figure-Recognition Trial (MTCF-RT) to differentiate amnestic patients with Alzheimer's disease from patients with memory deficits due to Parkinson's disease or subcortical ischemic vascular dementia.

IF 3 3区心理学 Q3 NEUROSCIENCES

Neuropsychology Pub Date : 2025-10-01 Epub Date: 2025-08-25 DOI:10.1037/neu0001036

Edoardo Barvas, Giulia Mattavelli, Susanna Guttmann, Costanza Papagno

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Abstract

Objective: The Modified Taylor Complex Figure-Recognition Trial (MTCF-RT) is a visual recognition memory measure that consists of a recognition trial to be administered after the copy and the delayed reproduction of the Modified Taylor Complex Figure Test. The aim of this study was to validate the MTCF-RT in differentiating amnestic patients with Alzheimer's disease (AD) from patients with memory deficits due to Parkinson's disease (PD) or subcortical ischemic vascular dementia (SIVD).

Method: The MTCF-RT was administered to 25 amnestic patients with AD and 25 patients with memory deficits due to SIVD (n = 18) or PD (n = 7). Additionally, the recognition trial was administered to 40 neurologically unimpaired individuals. All patients were tested on a brief neuropsychological battery, and their magnetic resonance scans were assessed for medial temporal lobe atrophy.

Results: MTCF-RT performance was significantly lower in the group of amnestic patients with AD than in the group of amnestic patients with non-AD disorders, whereas healthy subjects performed significantly better than the two experimental groups. The MTCF-RT allowed identifying amnestic patients with AD with 92% sensitivity and 96% specificity using a cutoff of ≤7.358, showing a higher discriminant power with respect to other long-term memory measures. Finally, MTCF-RT scores showed a high negative correlation with medial temporal lobe atrophy and a positive correlation with other long-term memory measures.

Conclusions: MTCF-RT could be a useful tool, as part of a larger neuropsychological battery, for discriminating patients with AD from those with memory deficits due to PD or SIVD. (PsycInfo Database Record (c) 2025 APA, all rights reserved).

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使用改进的泰勒复杂图形识别试验（MTCF-RT）来区分阿尔茨海默病的遗忘患者与帕金森病或皮质下缺血性血管性痴呆引起的记忆缺陷患者。

目的：改良泰勒复图识别试验（MTCF-RT）是一项视觉识别记忆测试，包括在改良泰勒复图测试的复制和延迟复制后进行的识别试验。本研究的目的是验证MTCF-RT在区分阿尔茨海默病（AD）遗忘患者与帕金森病（PD）或皮层下缺血性血管性痴呆（SIVD）引起的记忆缺陷患者中的作用。方法：对25例AD遗忘患者和25例SIVD或PD所致记忆缺陷患者（n = 18）进行MTCF-RT。此外，对40名神经系统未受损的个体进行了识别试验。所有的病人都接受了简短的神经心理学测试，他们的磁共振扫描被评估为内侧颞叶萎缩。结果：伴有AD的遗忘患者MTCF-RT表现显著低于无AD障碍的遗忘患者组，而健康受试者的MTCF-RT表现显著优于两个实验组。MTCF-RT识别AD遗忘患者的灵敏度为92%，特异性为96%，截止值≤7.358，与其他长期记忆测量相比具有更高的判别能力。最后，MTCF-RT评分与内侧颞叶萎缩呈高度负相关，与其他长期记忆测量呈正相关。结论：MTCF-RT可能是一种有用的工具，作为更大的神经心理学电池的一部分，用于区分AD患者与PD或SIVD引起的记忆缺陷患者。（PsycInfo Database Record (c) 2025 APA，版权所有）。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Neuropsychology 医学-神经科学

CiteScore

4.10

自引率

4.20%

发文量

132

审稿时长

6-12 weeks

期刊介绍： Neuropsychology publishes original, empirical research; systematic reviews and meta-analyses; and theoretical articles on the relation between brain and human cognitive, emotional, and behavioral function.