Neuropsychology最新文献

{"title":"Degree of self-certainty is related to the association between cognitive flexibility and anxiety following breast cancer treatments.","authors":"Joy Perrier, Mylène Duivon, Bénédicte Clarisse, François Christy, François Gernier, Djelila Allouache, Sabine Noal, Christelle Levy, Jacques Dayan, Fausto Viader, Florence Joly, Francis Eustache, Bénédicte Giffard","doi":"10.1037/neu0001127","DOIUrl":"https://doi.org/10.1037/neu0001127","url":null,"abstract":"<p><strong>Objective: </strong>Executive functioning difficulties-notably cognitive flexibility-are frequent following breast cancer (BC) treatment. Conflicting findings suggest that factors beyond anticancer treatments contribute to these changes. Anxiety and self-representation modifications are potential contributors. We explored the relationships among self-representations, anxiety, and cognitive flexibility in women with nonmetastatic BC compared with healthy controls (HCs).</p><p><strong>Method: </strong>We compared 54 BC patients to 47 HCs. We collected questionnaire data on self-representations (Questionnaire of Self-Representation: certainty and valence), state-trait anxiety (State-Trait Anxiety Inventory), and cognitive flexibility (Trail Making Test). Group comparisons were made using t tests or Wilcoxon tests, as appropriate. Spearman's correlations were calculated within each group. Linear regression was used to evaluate how self-representations were associated with the anxiety-cognitive flexibility relationship.</p><p><strong>Results: </strong>BC patients had higher self-certainty and Trail Making Test scores, indicating slightly reduced cognitive flexibility compared with HCs. In both groups, lower Questionnaire of Self-Representation scores (i.e., less certainty and positivity about oneself) correlated with higher anxiety. In HCs, higher Trail Making Test scores-thus lower cognitive flexibility-correlated with lower Questionnaire of Self-Representation scores and higher anxiety. In BC patients, higher levels of self-certainty were associated with a statistically positive anxiety-cognitive flexibility relationship (i.e., higher anxiety linked to poorer cognitive flexibility), while lower levels of self-certainty were associated with a statistically negative anxiety-cognitive flexibility relationship (lower anxiety linked to better cognitive flexibility).</p><p><strong>Conclusions: </strong>These findings suggest that, in BC patients, self-certainty moderates the relationship between anxiety and cognitive flexibility in BC patients. The results highlight the relevance of self-representation in the neuropsychological evaluation of BC patients. (PsycInfo Database Record (c) 2026 APA, all rights reserved).</p>","PeriodicalId":19205,"journal":{"name":"Neuropsychology","volume":" ","pages":""},"PeriodicalIF":2.9,"publicationDate":"2026-10-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149112829","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Promoting digital memory aid use in older adults with cognitive concerns: A pilot randomized controlled trial of adaptive web-based training.","authors":"Maureen Schmitter-Edgecombe, Catherine Luna, Reanne Cunningham Chilton, Samina Rahman, Brooke F Beech, Xingzi Li, Maggie Dines, Shenghai Dai, Diane J Cook","doi":"10.1037/neu0001071","DOIUrl":"10.1037/neu0001071","url":null,"abstract":"<p><strong>Objective: </strong>This pilot study evaluated a web-based adaptive training platform for teaching older adults with cognitive concerns to use the Electronic Memory and Management Aid (EMMA), a digital cognitive support tool. Outcomes were compared between a self-guided, technical support-only condition and a clinician-supported (M + T) condition that included motivational enhancement.</p><p><strong>Method: </strong>Primarily White, community-dwelling older adults with self-reported cognitive concerns (<i>N</i> = 62) were randomized to one of two conditions. Over 4 weeks, 49 participants successfully completed six adaptive, web-based lessons. The M + T group received weekly clinician-led motivational sessions; both groups had access to technical support. Primary outcomes assessed at baseline and 3 months posttraining included EMMA app usage, everyday function, and self-reported cognitive self-efficacy and health. Secondary outcomes included perceived cognition, coping self-efficacy, compensation use, and medication management.</p><p><strong>Results: </strong>Both groups showed comparable EMMA engagement and improvements in applied everyday cognition (η² = .14), with no significant group-by-time interaction. Medium effect sizes (η² = .06-.09) were observed for other outcomes but did not reach significance. App usage did not predict improvements in applied everyday cognition; however, participants with lower baseline self-efficacy and greater perceived cognitive difficulties used the app more frequently. Qualitative feedback highlighted EMMA's usability and benefits for daily organization, alongside barriers to sustained use.</p><p><strong>Conclusions: </strong>A self-guided, adaptive training platform with minimal clinician support may be sufficient to promote engagement with a digital memory aid. Findings support scalable digital interventions and underscore the role of perceived need in technology adoption. (PsycInfo Database Record (c) 2026 APA, all rights reserved).</p>","PeriodicalId":19205,"journal":{"name":"Neuropsychology","volume":" ","pages":"763-779"},"PeriodicalIF":2.9,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147777299","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Depression and anxiety modify cognitive concerns associated with amyloid and early clinical impairment.","authors":"Shana D Stites, Rosalie Schumann, Yidan Shi, Dawn Mechanic-Hamilton, David A Wolk","doi":"10.1037/neu0001086","DOIUrl":"10.1037/neu0001086","url":null,"abstract":"<p><strong>Objective: </strong>Cognitive concerns (CCs) are common for patients with Alzheimer's disease (AD) dementia. We explore anxiety, depression, and clinical impairment as moderators of CCs in early AD. Understanding these associations may help inform efforts to advance early identification of disease progression in AD.</p><p><strong>Method: </strong>Data sources, selected based on requirements for availability of biomarker data and clinical assessment data, generated a pooled sample of adults ages 65+ with known amyloid status and cognitive function ranging from unimpaired (Clinical Dementia Rating global score [CDR-GS] = 0, <i>n</i> = 5,498) to early impairment (CDR-GS = 0.5, <i>n</i> = 504). Measures of CCs, anxiety, and depression were standardized to cognitively unimpaired groups. To model the difference in effects for different levels of anxiety and depression, we used mixed-effects quantile regression for median adjusted for age, sex, race, and educational years. All reported findings are <i>p</i> < .05.</p><p><strong>Results: </strong>Higher CCs were associated with early clinical impairment (estimated change in median [β] = 15.5). CCs were higher with higher versus lower anxiety, except in unimpaired persons with elevated amyloid. In this latter group of unimpaired persons with elevated amyloid, CCs were higher with higher versus lower depression.</p><p><strong>Conclusion: </strong>In combination elevated amyloid, anxiety, and depression may offer data to guide clinical interpretation of CCs in early clinical impairment. The findings advance understanding of mood effects in early AD and inform specific measurement considerations. Future longitudinal studies are needed. (PsycInfo Database Record (c) 2026 APA, all rights reserved).</p>","PeriodicalId":19205,"journal":{"name":"Neuropsychology","volume":" ","pages":"750-762"},"PeriodicalIF":2.9,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13290126/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148252214","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Repeated presentation of a word list in a consistent order increases differences in total words recalled between those with and without Alzheimer's disease.","authors":"Evan Grandoit, Seo-Eun Choi, Laura A Rabin, Roos J Jutten, Dan Mungas, Melissa Lamar, Nancy S Foldi, Beth E Snitz, C Elizabeth Shaaban, Emily H Trittschuh, Richard N Jones, Douglas Tommet, Shubhabrata Mukherjee, Phoebe Scollard, Michael L Lee, Brandon S Klinedinst, Chun Wang, Paul K Crane","doi":"10.1037/neu0001090","DOIUrl":"10.1037/neu0001090","url":null,"abstract":"<p><strong>Objective: </strong>Individuals with Alzheimer's disease (AD) are known to have difficulty utilizing semantic strategy to remember items from a list, such as during word list recall tasks. However, it is unclear if presenting words in the same order as compared to shuffling across trials of a list-learning test confers an advantage in terms of word recall in individuals with AD.</p><p><strong>Method: </strong>To address this issue, we leveraged data from 10,504 participants over five studies across four AD Research Centers that administered the Consortium to Establish a Registry for AD Word List Memory Test in either a standard sequence (shuffled words for each learning trial) or nonstandard sequence (unshuffled words in a consistent order for each learning trial).</p><p><strong>Results: </strong>After controlling for gender, age, years of education, apolipoprotein E gene, Clinical Dementia Rating Global Score, and composite test scores for executive functioning and language comprehension, we found that differences in word recall performance between participants with and without probable AD were larger when they were tested with the unshuffled versus standard shuffled version of the word list.</p><p><strong>Conclusions: </strong>When administered the unshuffled Consortium to Establish a Registry for AD Word List, participants without AD demonstrated a larger recall advantage compared to those with probable AD. This advantage was higher on Trial 3 (β = 0.09) compared to Trial 2 (β = 0.04), suggesting that this advantage increases with multiple immediate repetitions. Using an unshuffled word list may enhance the ability to distinguish between individuals along the AD continuum. (PsycInfo Database Record (c) 2026 APA, all rights reserved).</p>","PeriodicalId":19205,"journal":{"name":"Neuropsychology","volume":" ","pages":"736-749"},"PeriodicalIF":2.9,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13155764/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147699270","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Getting off-tract: Correlational tractography of white matter integrity and cognitive intraindividual variability in a large sample of community-dwelling older adults.","authors":"Ivan A Campbell, Nanako A Hawley, Celeste Reames, Brock Renicks, Stephen L Aita, Victor A Del Bene, Benjamin D Hill","doi":"10.1037/neu0001131","DOIUrl":"https://doi.org/10.1037/neu0001131","url":null,"abstract":"<p><strong>Objective: </strong>Cognitive intraindividual variability (IIV), or the dispersion across neuropsychological task performance, is a sensitive marker of neurocognitive aging, but its tract-specific white matter correlates are not well characterized. This study used correlational tractography to identify pathways whose microstructural integrity relates to IIV in older adults.</p><p><strong>Method: </strong>Participants were a diverse sample of 510 community-dwelling older adults (<i>M</i>_age = 66.6 years, <i>SD</i>_age = 8.4) from the Health and Aging Brain Study-Health Disparities cohort. IIV was computed as the intraindividual standard deviation of demographically normed performance <i>T</i> scores across a multidomain battery. Diffusion MRI connectometry in DSI Studio tested partial Spearman associations between IIV and quantitative anisotropy, adjusting for sex and intracranial volume, with permutation testing and false discovery rate adjustment (0.01).</p><p><strong>Results: </strong>Higher IIV was associated with lower quantitative anisotropy primarily in commissural corpus callosum, fronto-subcortical, and interhemispheric long-range connection fibers. Tracts of the forceps minor were the most robust to sensitivity analyses. Effects were small in magnitude, with the primary connectometry threshold corresponding to an effect size of 0.09, but spatially specific, accounting for 7.57% of total whole-brain tract volume.</p><p><strong>Conclusions: </strong>Overall, we found that IIV maps onto distributed, tract-specific differences in white matter microstructure. Findings support IIV as a marker linked to structural network-level white matter integrity and should motivate longitudinal work to further clarify its neuroanatomical substrates. (PsycInfo Database Record (c) 2026 APA, all rights reserved).</p>","PeriodicalId":19205,"journal":{"name":"Neuropsychology","volume":" ","pages":""},"PeriodicalIF":2.9,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149112857","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Altered temporal features of visual processing in subjective cognitive decline.","authors":"Mélanie Lévesque, Marc-Antoine Akzam-Ouellette, Sven Joubert, Martin Arguin","doi":"10.1037/neu0001128","DOIUrl":"https://doi.org/10.1037/neu0001128","url":null,"abstract":"<p><strong>Objective: </strong>Subjective cognitive decline (SCD) is possibly the earliest known stage of Alzheimer's disease. Individuals with SCD report perceiving a decline in their cognitive functioning and express concern about it. However, when assessed with standard neuropsychological tests, they perform within normal limits.</p><p><strong>Method: </strong>The present study focuses on the temporal features of visual processing in SCD using the random temporal sampling technique. This method reveals the perceptual oscillations which occur during a visual task by presenting stimuli with randomly varying signal-to-noise ratio through time. Fourteen individuals with SCD and 15 others without (i.e., controls), aged between 60 and 85 years old, took part in the study.</p><p><strong>Results: </strong>Participants with SCD performed within normal limits on neuropsychological tasks, as did the control group. In the experimental task, participants had to recognize briefly presented five-letter French words. The results take the form of classification images, which depict how visual processing efficiency fluctuates over time and across different frequency bands of signal-to-noise ratio oscillations. The classification images reveal significant differences between groups on the temporal patterns of visual processing. A machine learning classifier was used to categorize the data of individual participants according to group membership. The classifier achieved 79.3% classification accuracy using 18.0% of the available features.</p><p><strong>Conclusions: </strong>Even though SCD individuals show no detectable cognitive impairment in neuropsychological testing, random temporal sampling can reveal anomalies in their perceptual function. (PsycInfo Database Record (c) 2026 APA, all rights reserved).</p>","PeriodicalId":19205,"journal":{"name":"Neuropsychology","volume":" ","pages":""},"PeriodicalIF":2.9,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149112865","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Altered voxel-based and surface-based morphometry in insomnia with short and normal objective sleep duration.","authors":"Haobo Zhang, Zhangwei Lv, Hanfei Chen, Zijie Tang, Xu Lei","doi":"10.1037/neu0001109","DOIUrl":"https://doi.org/10.1037/neu0001109","url":null,"abstract":"<p><strong>Objective: </strong>Two subtypes of insomnia, classified by objective sleep duration, exhibit distinctly different clinical presentations. However, the brain morphological differences between subtypes remain poorly understood. This study aimed to compare the morphological differences between the objective short sleep duration (ISSD) and normal sleep duration (INSD) subtypes, using both voxel-based and surface-based morphometry analyses. We sought to determine whether morphological differences could serve as valid biomarkers to differentiate the subtypes.</p><p><strong>Method: </strong>Forty ISSD and 39 INSD were included in the study. T1-weighted images were acquired. Both voxel-based and surface-based morphological metrics, including gray matter volume, cortical thickness, cortical gyrification, cortical complexity, and sulcus depth, were compared between the two subtypes. The identified structural differences were then used as features to train a support vector machine model to distinguish the two subtypes.</p><p><strong>Results: </strong>No significant differences were found in cortical thickness, cortical gyrification, or cortical complexity between the ISSD and INSD subtypes. However, ISSD showed a significant reduction in gray matter volume in the bilateral putamen, while INSD exhibited a significant reduction in gray matter volume in the bilateral cerebellum. In terms of sulcus depth, the right superior temporal gyrus showed a significant reduction in ISSD when compared with INSD. Using the support vector machine, the model correctly classified the two subtypes with an accuracy of 76.9%, sensitivity of 70.2%, specificity of 83.8%, and an area under the curve of 0.835.</p><p><strong>Conclusions: </strong>ISSD and INSD differ in specific brain morphological features, and these findings may provide preliminary discriminative information at the group level. (PsycInfo Database Record (c) 2026 APA, all rights reserved).</p>","PeriodicalId":19205,"journal":{"name":"Neuropsychology","volume":" ","pages":""},"PeriodicalIF":2.9,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149112882","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Subjective cognitive concerns and global metacognitive bias in prodromal Parkinson's and Parkinson's disease without cognitive impairment.","authors":"Nishaat Mukadam, Abuzar Mahmood, Alice Cronin-Golomb, Joseph DeGutis","doi":"10.1037/neu0001083","DOIUrl":"10.1037/neu0001083","url":null,"abstract":"<p><strong>Objective: </strong>Subjective cognitive decline is common in persons with Parkinson's disease (PwPD) and prodromal PD (proPD) and predicts objective cognitive decline. Subjective concerns may reflect enhanced sensitivity to cognitive changes or negative global metacognitive biases (general underconfidence, not task specific) related to depression or anxiety. We evaluated the presence and predictors of metacognitive awareness, the self-assessment of one's cognitive abilities, in PwPD and proPD.</p><p><strong>Method: </strong>Data from 468 PwPD, 817 proPD, and 75 healthy control adults were drawn from the Parkinson's Progressive Markers Initiative database. Measures included subjective- and objective-cognitive composites. We assessed metacognitive sensitivity (the relation between subjective and objective cognition) and the relation between metacognitive bias (subjective minus objective cognition) and depression, anxiety, demographics, and PD-related variables. Significant associations were included in linear regression models separately for PwPD and proPD. To assess effect consistency, we examined baseline versus Time 2 difference scores in a subsample who had the same measures 12 months later.</p><p><strong>Results: </strong>ProPD (ρ = .13), but not PwPD (ρ = .08), showed significant metacognitive sensitivity. More negative metacognitive bias was predicted by age, education, depression, and trait anxiety in PwPD (<i>R</i>² = .17) and proPD (<i>R</i>² = .24). The relation between anxiety and negative metacognitive bias was consistent over a 12-month period for PwPD (ρ = -.18; <i>R</i>² = .05).</p><p><strong>Conclusions: </strong>Negative metacognitive bias, predicted by depression and anxiety, may underlie subjective cognitive concerns in PwPD and proPD, with implications for treatment. These findings support using global approaches to metacognitive awareness, which are likely more accurate measures of daily cognitive awareness than are task-specific measures. (PsycInfo Database Record (c) 2026 APA, all rights reserved).</p>","PeriodicalId":19205,"journal":{"name":"Neuropsychology","volume":" ","pages":"712-723"},"PeriodicalIF":2.9,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147699336","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A large language model-based self-learning and critical agent framework for multimodal Alzheimer's disease diagnosis.","authors":"Meiwei Zhang, Qiushi Cui, Yang Lü, Yuwei Pan, Weihua Yu, Wenyuan Li","doi":"10.1037/neu0001079","DOIUrl":"10.1037/neu0001079","url":null,"abstract":"<p><strong>Objective: </strong>We developed and evaluated a training-free, large language model (LLM) multiagent framework, consisting of role-prompted LLM instances, that simulates hospital-style team diagnosis for Alzheimer's disease, improving interpretability and generalizability for multimodal data.</p><p><strong>Method: </strong>We designed a self-learning and critical multiagent workflow comprising nine single-dimension agents and five senior agents that iteratively validate, retrieve experience, and refine decisions via self-evaluation and critique. Agents are augmented with an \"intelligence\" module and an experience-retrieval module. Participants were 1,362 Alzheimer's Disease Neuroimaging Initiative (ADNI) records spanning cognitively normal, mild cognitive impairment, and Alzheimer's disease from ADNI GO, ADNI 1, ADNI 2, ADNI 3, ADNI 4. The decision layer is not supervised on ADNI labels, and no end-to-end fine-tuning is performed on ADNI within this study.</p><p><strong>Results: </strong>The full self-learning and critical multiagent framework achieved an F1 score = 88%, sensitivity = 88%, and precision = 90% for three-way cognitively normal/mild cognitive impairment/Alzheimer's disease classification, providing case-level rationales. Relative to early agents, sequential self-learning and critique produced large effect gains. Single-dimension agents varied widely, while the integrated framework yielded the most balanced performance and higher answer relevancy on LLM-based metrics.</p><p><strong>Conclusions: </strong>A label-free LLM multiagent approach can integrate heterogeneous modalities, retain diagnostic \"experience,\" and generate transparent reasoning while delivering competitive accuracy on ADNI. The framework shows promise for real-world support of complex neuropsychological diagnosis; future work should incorporate fully multimodal LLMs for imaging and repeated, graph-driven iterations to further enhance performance. (PsycInfo Database Record (c) 2026 APA, all rights reserved).</p>","PeriodicalId":19205,"journal":{"name":"Neuropsychology","volume":" ","pages":"697-711"},"PeriodicalIF":2.9,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147513090","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Compensatory cue-weighting strategies for the sense of agency in patients with poststroke motor deficits.","authors":"Yu Miyawaki, Takeshi Otani, Masaki Yamamoto, Shu Morioka, Akihiko Murai","doi":"10.1037/neu0001073","DOIUrl":"10.1037/neu0001073","url":null,"abstract":"<p><strong>Objective: </strong>Poststroke motor deficits often result in diminished or degraded sensorimotor input, potentially disrupting how patients attribute actions and affecting their sense of agency (SoA)-that is, the experience of controlling one's own actions. SoA emerges from the integration of sensorimotor cues (e.g., prediction errors between internal prediction and sensory feedback) and cognitive cues (e.g., thoughts or beliefs). However, the integration mechanism of these cues remains unclear.</p><p><strong>Method: </strong>Twenty poststroke patients with sensorimotor deficits but no marked cognitive impairments, along with 10 healthy control participants, performed sinusoidal movements. During the movement, participants observed a cursor that either matched or deviated from their actual movements and judged whether the cursor reflected their own movement. We combined this task with questionnaires assessing reliance on cognitive cues and subjective SoA.</p><p><strong>Results: </strong>Patients with more severe motor deficits made more erroneous self-attributions (<i>p</i>s = .015, Cohen's <i>d</i>s = 1.27) and showed weaker correlation between pen-cursor distance and self-other judgment (β_dif = .23, <i>p</i> = .017), suggesting lower sensitivity to prediction error. Erroneous self-attribution correlated with greater reliance on cognitive cues (<i>r</i> = .76, <i>p</i> = .010). Although SoA generally decreased with motor deficit severity (βs = .67, <i>p</i>s < .001), patients with more severe deficits exhibited higher SoA when showing higher cognitive cue reliance (β = .58, <i>p</i> = .010) or longer time since stroke (β = .62, <i>p</i> = .004).</p><p><strong>Conclusions: </strong>Patients with more severe motor deficits may adopt compensatory cue-weighting strategies that rely more on cognitive than sensorimotor cues during agency registration. (PsycInfo Database Record (c) 2026 APA, all rights reserved).</p>","PeriodicalId":19205,"journal":{"name":"Neuropsychology","volume":" ","pages":"724-735"},"PeriodicalIF":2.9,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147499621","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}