Neuropsychology最新文献

{"title":"ChatGPT in intervention planning: Advancing clinical relevance and targeted care in cognitive rehabilitation.","authors":"Natalie F Edman, Megan L Lacritz, Keren Isufi, Andrew D Lokai, Heidi A Bender, Amanda Sacks-Zimmerman","doi":"10.1037/neu0001088","DOIUrl":"10.1037/neu0001088","url":null,"abstract":"<p><strong>Objective: </strong>We aim to introduce ChatGPT as a supportive tool in cognitive rehabilitation, examine the feasibility of its integration into clinical practice, and propose guidelines for its integration into evidence-based practice. The article is intended to provide a preliminary framework for how ChatGPT can be incorporated into cognitive rehabilitation therapy and does not serve as an empirical study.</p><p><strong>Method: </strong>We examine how artificial intelligence can assist cognitive rehabilitation interventionalists in targeting interventions to enhance clinical relevance. We present an illustrative intervention protocol guided by current cognitive rehabilitation principles and offer case examples demonstrating ChatGPT's role in creating clinically relevant practice activities tailored to individual needs.</p><p><strong>Results: </strong>Anecdotal feedback from patients was positive, with the patients reporting that practicing cognitive strategies using personally relevant information was enjoyable and easier to engage with compared to general practice tasks. This suggests that AI-generated tasks were engaging and relevant.</p><p><strong>Conclusion: </strong>The two cases provide an initial demonstration of how ChatGPT could be used to support the generation of personally relevant practice stimuli in cognitive rehabilitation, though further research is needed to assess its effectiveness and broader applicability. Importantly, the interventionist's expertise and active role in treatment planning, strategy selection, and progress evaluation remain central to the therapeutic process. We suggest that AI be utilized only as a supplemental tool in cognitive rehabilitation therapy, preserving the interventionist's active role in the therapeutic process.</p>","PeriodicalId":19205,"journal":{"name":"Neuropsychology","volume":" ","pages":"780-790"},"PeriodicalIF":2.9,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147777351","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exploring the relative contributions of multiple modifiable physical health variables to executive function and episodic memory performance in older adults.","authors":"Jessica H Stark, Ann J Lee, Kelly J Hiersche, Scott M Hayes","doi":"10.1037/neu0001072","DOIUrl":"10.1037/neu0001072","url":null,"abstract":"<p><strong>Objective: </strong>The majority of studies examining the relationship between fitness and cognition examine a single physical attribute. Here, we assessed the relative contributions of multiple modifiable physical health variables and demographic variables to cognition in healthy older adults.</p><p><strong>Method: </strong>Older adults (<i>N</i> = 619; <i>M</i>_age = 74.9, <i>SD</i> = 6.9) completed multiple physical health variable assessments (walking speed, respiratory function, grip strength, body mass index) and cognitive tasks as part of the Health and Retirement Study. Principal component analysis was used to inform cognitive composite scores, which revealed two domains: executive functions/processing speed and episodic memory. Lindeman, Merenda, and Gold's analysis was employed to assess the relative importance of demographic and modifiable physical health variables to each cognitive domain.</p><p><strong>Results: </strong>Age, education, walking speed, and respiratory function explained the greatest amount of variance in the relative importance analysis for both executive functions/processing speed and episodic memory. Modifiable variables, including walking speed and respiratory function, accounted for similar amounts of variance as age in predicting executive functions/processing speed performance. After controlling for demographic variables, modifiable physical health variables of walking speed and respiratory function collectively accounted for an additional 9.9% and 3.3% variance in executive functions/processing speed and episodic memory, respectively.</p><p><strong>Conclusions: </strong>These results indicated that modifiable physical health variables are differentially associated with cognitive performance. Fitness indicators can account for similar amounts of variance as age in executive functions/processing speed in healthy older adults. (PsycInfo Database Record (c) 2026 APA, all rights reserved).</p>","PeriodicalId":19205,"journal":{"name":"Neuropsychology","volume":" ","pages":"675-686"},"PeriodicalIF":2.9,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13178849/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147513553","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Monetary savings and neuropsychological functioning in older adults without dementia.","authors":"Cassidy P Molinare, Daisy T Noriega-Makarskyy, Jordan T Williams, Emma Oyen, Paige Kim, Jenna Axelrod, S Duke Han","doi":"10.1037/neu0001082","DOIUrl":"10.1037/neu0001082","url":null,"abstract":"<p><strong>Objective: </strong>Socioeconomic status has been associated with cognitive functioning across the lifespan, but specific neuropsychological and economic components were not considered by previous studies. Here, we investigated monetary savings as a measure of socioeconomic status and its association with performance across multiple neuropsychological measures in older adults without dementia.</p><p><strong>Method: </strong>Participants included 111 individuals (<i>M</i>_age = 68.5, <i>SD</i> = 7.2; <i>M</i> years of education = 16.7, <i>SD</i> = 2.2; 73% female; 75.7% White) recruited from the greater Los Angeles area. Demographic data, household income, and combined monetary savings across checking and savings accounts were self-reported through a questionnaire. Participants completed cognitive measures from the National Alzheimer's Coordinating Center Uniform Data Set, Version 3, and the National Institutes of Health Toolbox Cognitive Battery, Version 2. Multiple linear regression analyses were conducted to evaluate associations between monetary savings and each cognitive measure. All analyses controlled for age, sex, years of education, and income.</p><p><strong>Results: </strong>Greater monetary savings were associated with greater performance on a fluid cognition domain (<i>b</i> = 1.18, 95% CI [0.10, 2.25], <i>p</i> = .032), and more specifically on an inhibitory control task (<i>b</i> = 0.98, 95% CI [0.25, 1.70], <i>p</i> = .009). Post hoc analyses demonstrated that this effect was driven by individuals with above-median savings <i>(b</i> = 2.02, 95% CI [0.04, 3.99], <i>p</i> = .045).</p><p><strong>Conclusions: </strong>Our findings suggest that greater inhibitory control is associated with greater monetary savings and that this relationship is more salient among older individuals with relatively high savings. Further research is needed to determine the underlying mechanisms of this association. (PsycInfo Database Record (c) 2026 APA, all rights reserved).</p>","PeriodicalId":19205,"journal":{"name":"Neuropsychology","volume":" ","pages":"687-696"},"PeriodicalIF":2.9,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13078639/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147645938","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Factor structure of the neuropsychological battery in the Mexican Cognitive Aging Ancillary Study (Mex-Cog).","authors":"Lily Kamalyan, Zachary J Kunicki, Sangha Jeon, Guanyi Yang, Silvia Mejia-Arango, Alejandra Michaels Obregon, Rebeca Wong, Joseph Saenz, Emily M Briceño, Miguel Arce Rentería","doi":"10.1037/neu0001119","DOIUrl":"10.1037/neu0001119","url":null,"abstract":"<p><strong>Objective: </strong>The Mexican Cognitive Aging Ancillary Study administers a comprehensive cognitive assessment based on the Harmonized Cognitive Assessment Protocol. To ensure accurate measurement of cognition for older adults in Mexico, we sought to determine the cognitive factor model of the Mexican Cognitive Aging Ancillary Study battery at Wave 1.</p><p><strong>Method: </strong>Participants were 2,042 adults over the age of 55 living in Mexico in 2016, selected from the Mexican Health and Aging Study survey of 2015. We used confirmatory factor analysis to assess and refine a theoretically driven multiple domain hierarchical factor structure. Correlation estimates between cognitive scores and age and education were evaluated.</p><p><strong>Results: </strong>The hierarchical general cognition and five-domain models (orientation, memory, language, executive functioning, and visuospatial) were identified as reasonable models for summarizing performance in this sample. Cognitive domains were negatively associated with age (<i>r</i>s = -.31 to -.49) and positively associated with education (<i>r</i>s = .43-.74).</p><p><strong>Conclusions: </strong>The Mexican Cognitive Aging Ancillary Study battery demonstrated a reliable cognitive factor structure that assesses the domains of orientation, memory, language, executive functioning, and visuospatial functioning. A hierarchical general cognition factor score was also created. The derived scores can be used to accurately demonstrate cognitive performance among Mexican older adults. Future work will focus on measurement invariance across demographic groups and evaluating the factor structure of Wave 2. (PsycInfo Database Record (c) 2026 APA, all rights reserved).</p>","PeriodicalId":19205,"journal":{"name":"Neuropsychology","volume":" ","pages":""},"PeriodicalIF":2.9,"publicationDate":"2026-09-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13623209/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149075307","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Decoupling of local activity and interhemispheric connectivity in late mild cognitive impairment: A resting-state functional magnetic resonance imaging study.","authors":"Zhishuai Jin","doi":"10.1037/neu0001124","DOIUrl":"10.1037/neu0001124","url":null,"abstract":"<p><strong>Objective: </strong>Mild cognitive impairment (MCI), a high-risk precursor to Alzheimer's disease, progresses through early (EMCI) and late (LMCI) stages. While distinct functional brain alterations between EMCI and LMCI have been reported, differences in regional brain activity and interhemispheric functional connectivity during resting-state remain incompletely characterized. The aim of the study was to systematically assess the differences in resting-state brain functional alterations between the LMCI patients and EMCI patients.</p><p><strong>Method: </strong>We assessed resting-state functional alterations in EMCI and LMCI using fractional amplitude of low-frequency fluctuations (fALFF) and voxel-mirrored homotopic connectivity (VMHC). Data from 35 EMCI patients, 28 LMCI patients, and 37 individuals with normal cognition were analyzed from the Alzheimer's Disease Neuroimaging Initiative-Phase 2.</p><p><strong>Results: </strong>Compared to EMCI patients, LMCI patients exhibited increased fALFF in the left inferior temporal gyrus and left precentral gyrus, alongside decreased VMHC in the anterior cerebellar lobe and posterior cingulate cortex. Among MCI patients, Montreal Cognitive Assessment scores showed a significant negative correlation with fALFF in the left inferior temporal gyrus/left precentral gyrus but a significant positive correlation with VMHC in the anterior cerebellar lobe/posterior cingulate cortex.</p><p><strong>Conclusions: </strong>These findings suggest that elevated regional activity (fALFF) may represent a compensatory mechanism, while reduced interhemispheric connectivity (VMHC) reflects a neuropathological basis underlying progression from EMCI to LMCI. (PsycInfo Database Record (c) 2026 APA, all rights reserved).</p>","PeriodicalId":19205,"journal":{"name":"Neuropsychology","volume":" ","pages":""},"PeriodicalIF":2.9,"publicationDate":"2026-09-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149075343","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Psychometric properties of the Survey of Health, Aging, and Retirement in Europe Harmonized Cognitive Assessment Protocol (SHARE-HCAP).","authors":"Marcela C Otero, Irene Fernández, Salima Douhou, Axel Börsch-Supan","doi":"10.1037/neu0001125","DOIUrl":"https://doi.org/10.1037/neu0001125","url":null,"abstract":"<p><strong>Objective: </strong>Standardized cross-national assessments of cognitive functioning remain scarce despite dementia being a major global health concern. This study examined the psychometric properties of the Survey of Health, Aging, and Retirement in Europe Harmonized Cognitive Assessment Protocol, a newly developed cognitive assessment instrument for Europe. Sample included 2,685 adults aged 65+ from the Czech Republic, Denmark, France, Germany, and Italy.</p><p><strong>Method: </strong>Confirmatory factor analyses tested unidimensional models for five cognitive domains-memory, executive functioning, visuospatial skills, language/fluency, and orientation-alongside correlated and second-order factor models. A second-order structure showed adequate fit, supporting five domain factors and one general cognitive performance factor.</p><p><strong>Results: </strong>Factor scores were positively associated with education and negatively with age, and approximate measurement invariance of the five cognitive domain scores was supported across countries.</p><p><strong>Conclusions: </strong>These findings establish the Survey of Health, Aging, and Retirement in Europe Harmonized Cognitive Assessment Protocol as a psychometrically sound tool for cross-national comparisons of cognitive health. (PsycInfo Database Record (c) 2026 APA, all rights reserved).</p>","PeriodicalId":19205,"journal":{"name":"Neuropsychology","volume":" ","pages":""},"PeriodicalIF":2.9,"publicationDate":"2026-09-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149075299","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Into the multiverse: Applications to neuropsychology.","authors":"C L Baird, H A Mullin, F G Hillary","doi":"10.1037/neu0001094","DOIUrl":"10.1037/neu0001094","url":null,"abstract":"<p><strong>Objective: </strong>In neuropsychology, the heterogeneity of clinical syndromes combined with extensive methodological options creates a complex decision tree of pathways that result in a range of possible findings. A multiverse approach is a framework for navigating this uncertainty, allowing researchers to explore the impact of analytic decisions and assess the robustness of research findings. In this article, we demonstrate how multiverse can be applied to examine outcomes following traumatic brain injury (TBI).</p><p><strong>Method: </strong>Publicly available data from the Citicoline Brain Injury Treatment Trial research study (Zafonte et al., 2012) was used to showcase how multiverse can assess the effects of TBI severity using the specr and multiverse packages in R (v 4.3.1). We analyzed data from 159 adults (122 male; <i>M</i> = 40.30, <i>SD</i> = 15.80) with complicated mild or moderate-to-severe TBI. We also simulate data sets of various sample sizes (<i>N</i> = 40, 100, 300, 1000) to further evaluate the robustness of our results.</p><p><strong>Results: </strong>For quality-of-life outcomes, 66.7% of models showed a significant relationship with TBI severity. Increased TBI severity did not predict life satisfaction (Satisfaction With Life Scale) but was consistently associated with greater disability on the Disability Rating Scale. Processing speed models were significant in 88% of cases, with greater TBI severity predicting decreased processing speed. Mood symptom models were nonsignificant, indicating that TBI severity alone did not predict mood.</p><p><strong>Conclusions: </strong>Multiverse uncovers insights that would have remained hidden under traditional approaches and has broad applications which can enhance scientific rigor and facilitate the translation of research into clinical interventions. (PsycInfo Database Record (c) 2026 APA, all rights reserved).</p>","PeriodicalId":19205,"journal":{"name":"Neuropsychology","volume":" ","pages":""},"PeriodicalIF":2.9,"publicationDate":"2026-09-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149012558","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Utilizing intraindividual cognitive variability to predict progression in stage 2 neuronal synuclein disease.","authors":"Hannah L Combs, Ryan Kurth, Anuprita Nair, Michele K York, Daniel Weintraub, David-Erick Lafontant, Chelsea Caspell-Garcia","doi":"10.1037/neu0001105","DOIUrl":"10.1037/neu0001105","url":null,"abstract":"<p><strong>Objective: </strong>Neuronal synuclein disease (NSD) involves pathological α-synuclein presence and often dopaminergic dysfunction, initially preceding overt clinical symptoms. NSD-Integrated Staging System identifies Stage 2A (no dopaminergic dysfunction) and 2B (dopaminergic dysfunction) as prodromal phases marked by subtle clinical signs without functional impairment. Intraindividual variability/dispersion (IIV-D), reflecting the degree of spread in a person's performance across a battery of cognitive tasks, has emerged as a potential marker of early neurodegenerative changes. This study examined whether IIV-D differentiates NSD Stage 2 participants from healthy controls and predicts progression to more advanced NSD stages.</p><p><strong>Method: </strong>Data from the Parkinson's Progression Markers Initiative were used to assess performance across 11 neuropsychological tests in 934 participants (832 Stage 2; 102 controls). IIV-D was primarily quantified using the total coefficient of variation (CoV) and a domain-specific attention/executive CoV. Secondary exploratory analyses examined total intraindividual standard deviation (i<i>SD</i>) and attention/executive i<i>SD</i>. Group comparisons and logistic regression assessed associations between IIV-D, clinical characteristics, and disease progression.</p><p><strong>Results: </strong>Stage 2 participants exhibited significantly greater CoV (<i>p</i> = .003) and iSD (<i>p</i> < .001) than controls. Higher CoV was associated with worse motor symptoms, nonmotor burden, and functional impairment. Among Stage 2 participants, subsequent converters to Stage 3+ (<i>n</i> = 100) had significantly higher total CoV (<i>p</i> = .008) and attention/executive CoV (<i>p</i> = .020) at baseline. CoV independently predicted conversion after 1 year (<i>OR</i> = 1.44, <i>p</i> = .008), controlling for baseline motor severity. By contrast, neither i<i>SD</i> nor attention/exeutive i<i>SD</i> predicted progression in analogous models.</p><p><strong>Conclusions: </strong>IIV-D, particularly CoV, may be a sensitive cognitive marker of early NSD and predict short-term disease progression. Measures of i<i>SD</i> did not demonstrate predictive utility. Findings support integrating cognitive dispersion metrics into early detection strategies for prodromal synucleinopathies, though replication is needed to confirm generalizability and clinical utility. (PsycInfo Database Record (c) 2026 APA, all rights reserved).</p>","PeriodicalId":19205,"journal":{"name":"Neuropsychology","volume":" ","pages":""},"PeriodicalIF":2.9,"publicationDate":"2026-09-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148930384","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Does the serial position effect identify those at risk for dementia? Findings from the Canadian Longitudinal Study on Aging.","authors":"Sofia Marinou, Paul Mick, Natalie A Phillips","doi":"10.1037/neu0001123","DOIUrl":"10.1037/neu0001123","url":null,"abstract":"<p><strong>Objective: </strong>Subjective cognitive decline (SCD), or a self-perceived decline in cognition without objective cognitive impairment, is a potential predictor of Alzheimer's disease. However, summary-level scores on objective neuropsychological measures often fail to detect subtle cognitive changes in this population. The serial position effect (SPE), where individuals tend to recall items presented at the beginning (primacy) and end (recency) of a word list better than ones in the middle, may provide greater sensitivity. Although altered SPE patterns have been observed in Alzheimer's disease, SPEs remain understudied in SCD.</p><p><strong>Method: </strong>Using data from the Canadian Longitudinal Study on Aging, we examined cross-sectional and longitudinal SPE patterns and serial position ratio scores in older adults aged 60 years and above. Participants were categorized as controls, SCD-no worry, and SCD + worry based on self-report measures of SCD and related worry. SPE indices were derived from the Rey Auditory Verbal Learning Test.</p><p><strong>Results: </strong>In cross-sectional analyses, the SCD + worry group had lower primacy recall than controls on both Rey Auditory Verbal Learning Test trials (immediate: <i>b</i> = -1.93; 5-min delayed: <i>b</i> = -1.89; <i>p</i>s < .01). In contrast, both SCD subgroups had higher recency recall on the immediate trial (SCD-no worry: <i>b</i> = 1.40; SCD + worry: <i>b</i> = 2.46; <i>p</i>s < .05) and higher recency ratios than controls (SCD-no worry: <i>b</i> = 0.07; SCD + worry: <i>b</i> = 0.08; <i>p</i>s < .001). Longitudinally, the SCD-no worry group experienced greater decline in primacy recall than controls across both Rey Auditory Verbal Learning Test trials (immediate: <i>b</i> = -3.05; 5-min delayed: <i>b</i> = -3.49; <i>p</i>s < .05).</p><p><strong>Conclusions: </strong>SPE patterns may capture subtle memory changes in SCD and could serve as sensitive markers for identifying those at elevated risk of future cognitive decline. (PsycInfo Database Record (c) 2026 APA, all rights reserved).</p>","PeriodicalId":19205,"journal":{"name":"Neuropsychology","volume":" ","pages":""},"PeriodicalIF":2.9,"publicationDate":"2026-09-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148930238","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cortical correlates of apathy in cerebral autosomal-dominant arteriopathy with subcortical infarcts and leukoencephalopathy with two different pathogenic mutations in the NOTCH3 gene.","authors":"Natascia De Lucia, Michele Ragno, Gabriella Cacchiò, Giulio Papiri, Nelson Mauro Maldonato, Massimo Caulo, Luigi Pianese, Giuseppe De Michele, Luigi Trojano","doi":"10.1037/neu0001110","DOIUrl":"10.1037/neu0001110","url":null,"abstract":"<p><strong>Objective: </strong>Cerebral autosomal-dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) patients may frequently manifest apathy. The cognitive and neural mechanisms underlying apathy in CADASIL have not been assessed systematically. The aim was to investigate neuropsychological and brain morphological features associated with apathy in patients with p.R1006C in exon 19 (nucleotide change c.3016C>T) and p.G528C in exon 10 (nucleotide change c.1582 G>T) mutations of the <i>NOTCH3</i> gene.</p><p><strong>Method: </strong>A total of 53 CADASIL patients (<i>M</i>_age ± <i>SD</i>, 56.6 ± 10.3; <i>M</i>_education ± SD, 10.8 ± 3.7), with p.R1006C mutation or p.G528C mutation, and 20 age and education-matched healthy adults underwent an extensive assessment of cognitive functions and apathetic symptoms. All the participants underwent an magnetic resonance imaging study of the brain assessing the amount of white matter lesions and quantifying brain and gray matter volumes.</p><p><strong>Results: </strong>Apathy occurred in 24/53 patients (45.2%). Both apathetic and nonapathetic patients showed significantly poorer performance than controls in executive and memory tasks (all <i>d</i> > 0.8). Apathetic patients performed worse than nonapathetic patients on Trail Making Test (<i>d</i> = 0.61) and higher scores in apathy evaluation (<i>d</i> = 5.12). Morphometric analyses revealed that apathy was correlated with reduced right insula gray matter volume (<i>r</i> = .50). The p.R1006C mutation group exhibited a higher prevalence of apathy (φ = .34), more severe cognitive impairment, and smaller right insular volume (<i>r</i> = -.64) compared with p.G528C. Logistic regression identified right insular atrophy as the only predictor of apathy (<i>OR</i> = 1.002; <i>p</i> = .02).</p><p><strong>Conclusions: </strong>Apathy is frequent in patients with CADASIL p.R1006C mutation and is correlated with reduced gray matter volume of the right insula. These findings contribute to better understand the neural correlates of apathy. (PsycInfo Database Record (c) 2026 APA, all rights reserved).</p>","PeriodicalId":19205,"journal":{"name":"Neuropsychology","volume":" ","pages":"655-663"},"PeriodicalIF":2.9,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148252139","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}