Behavioural Pharmacology最新文献

{"title":"Psilocybin enhances conditioned place preference learning in planarians.","authors":"Bart A Ellenbroek, Beth Naylor, Jiun Youn","doi":"10.1097/FBP.0000000000000903","DOIUrl":"https://doi.org/10.1097/FBP.0000000000000903","url":null,"abstract":"<p><p>Psilocybin has emerged as a promising therapeutic agent, with clinical benefits attributed to enhanced neuroplasticity rather than acute pharmacological effects. However, the fundamental mechanisms underlying these effects remain poorly understood. Using planarians as a model system, we investigated whether psilocybin enhances associative learning using a conditioned place preference paradigm. Following a single exposure to 5 µM psilocybin, planarians underwent 5 days of conditioning in which light was paired with sucrose. Psilocybin-treated planarians showed a significantly greater shift in light preference compared to controls (time × group × drug interaction: F(2,38) = 3.3, P < 0.05), with effects persisting at least 6 days post-administration. These findings demonstrate that psilocybin enhances appetitive associative learning in an invertebrate model, supporting the hypothesis that psychedelic-induced neuroplasticity operates through evolutionarily conserved serotonergic mechanisms.</p>","PeriodicalId":8832,"journal":{"name":"Behavioural Pharmacology","volume":" ","pages":""},"PeriodicalIF":1.4,"publicationDate":"2026-10-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149164646","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Behavioural phenotyping with small aquatic model organisms: why digital video resolution and bitrate matter.","authors":"Hy Do, Florian Kreuder, Xuhui Han, Michael Didham, Savita Kumari, Oskar Wasielewski, Jan Kaslin, Paul A Ramsland, Antoine M Dujon, Donald Wlodkowic","doi":"10.1097/FBP.0000000000000892","DOIUrl":"10.1097/FBP.0000000000000892","url":null,"abstract":"<p><p>Behavioural analysis with small aquatic model organisms is increasingly applied across diverse areas of biosciences and biomedicine, including ecology, pharmacology, and experimental neurobiology. High-throughput behavioural phenotyping workflows frequently employ organisms such as larval zebrafish ( Danio rerio ) in multiwell laboratory plates, yet the considerable cost of commercial imaging platforms often limits access for smaller laboratories, early career investigators and researchers in low- and middle-income countries. Here, we describe a rapid and practical approach for constructing an inexpensive, flexible and fully customisable behavioural data acquisition system suitable for use with a broad range of aquatic model species. We also examine an important but frequently overlooked methodological issue in quantitative behavioural research: how video acquisition parameters, particularly resolution and bitrate, influence the reliability of automated animal tracking. Using Artemia franciscana nauplii, adult Daphnia carinata , and 7 days postfertilisation larval Danio rerio , we show that video resolution is a major determinant of detection reliability, particularly for very small test organisms. Artemia franciscana could not be reliably tracked in multiarena configurations at resolutions below full high definition, whereas ultra high definition (3840 × 2160 pixels) provided robust detection across all tested species. We also show that concerns regarding ultra high definition file size can be mitigated by optimising bitrate settings. Moderate compression produced major reductions in file size while preserving detection reliability at practical compression levels. Together, these findings provide a practical framework for designing affordable and custom animal tracking systems and selecting video acquisition settings that support reliable high-throughput behavioural phenotyping across diverse aquatic species.</p>","PeriodicalId":8832,"journal":{"name":"Behavioural Pharmacology","volume":" ","pages":"198-209"},"PeriodicalIF":1.4,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148418340","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sex-dependent analgesic effects of phoenixin-14 on mechanical allodynia in mouse models of neuropathic and inflammatory pain.","authors":"Jing Li, WeiWei Li, Zhe Wang, Zhanfei Xu","doi":"10.1097/FBP.0000000000000895","DOIUrl":"10.1097/FBP.0000000000000895","url":null,"abstract":"<p><p>Chronic pain is a common complication of many diseases, often leading to severe hyperalgesia and allodynia with limited therapeutic options. Opioids are restricted in widespread clinical use due to side effects such as addiction and tolerance. Therefore, identifying novel pain-modulating targets is of great significance for the comprehensive and long-term treatment of chronic pain. This study reports that an endogenous polypeptide, phoenixin-14 (PNX-14), exhibits sexually dimorphic regulatory effects in various pain models. Briefly, intrathecally administered PNX-14 produces a more potent, dose-dependent elevation of pain thresholds in female mice than in male mice under physiological conditions. In models of spared nerve injury-induced neuropathic pain and complete Freund's adjuvant-induced inflammatory pain, intrathecal injection of PNX-14 elicited antinociceptive responses in both sexes, yet the magnitude observed in females was significantly greater than that in males. Further investigation revealed that this sexually dimorphic effect is not attributable to differential pharmacokinetics, as the plasma half-life of PNX-14 shows no difference between male and female mice both in vivo and in vitro . Notably, surgical and pharmacological manipulations revealed that PNX-14-regulated pain is promoted by estrogen but suppressed by androgen, suggesting an involvement of sex hormones. These results collectively position PNX-14 as a novel, nonopioid, and female-specific target for chronic pain management.</p>","PeriodicalId":8832,"journal":{"name":"Behavioural Pharmacology","volume":" ","pages":"277-288"},"PeriodicalIF":1.4,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148668313","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Curcumin mitigates memory deficits induced by subcutaneous aluminum nanoparticle administration through modulation of hippocampal brain-derived neurotrophic factor and Akt signaling pathways: Erratum.","authors":"Samaneh Reiszadeh Jahromi, Zahra Keikhosravi, Roksana SoukhakLari, Maryam Moosavi","doi":"10.1097/FBP.0000000000000891","DOIUrl":"https://doi.org/10.1097/FBP.0000000000000891","url":null,"abstract":"","PeriodicalId":8832,"journal":{"name":"Behavioural Pharmacology","volume":"37 5","pages":"303"},"PeriodicalIF":1.4,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148890895","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Conditioned place preference and conditioned place aversion in goldfish.","authors":"Shigeru Watanabe","doi":"10.1097/FBP.0000000000000887","DOIUrl":"10.1097/FBP.0000000000000887","url":null,"abstract":"<p><p>Some drugs possess reinforcing properties, which are commonly studied using the conditioned place preference (CPP) paradigm. CPP has been applied across a wide range of taxa, including nonmammalian vertebrates and invertebrates. In the present study, goldfish were used as an experimental model to examine CPP induced by nicotine, a substance that remains a major public health concern. Nicotine produced CPP at lower doses and conditioned place aversion (CPA) at higher doses. One advantage of fish models is the feasibility of drug administration by immersion, an animal-friendly alternative to injection. However, because intraperitoneal injection is the standard method in rodent studies, quantitative comparisons of dose-response relationships across taxa are difficult. To address this issue, I compared the dose-response relationship of general activity following nicotine administration by immersion with that following intraperitoneal injection in goldfish. Based on this comparison, a conversion factor between the two administration procedures was estimated. Using this conversion, nicotine-induced CPP and CPA in goldfish were quantitatively compared with findings from rodent studies. These results contribute to cross-species evaluation of drug reinforcement and support the utility of fish models in behavioral pharmacology.</p>","PeriodicalId":8832,"journal":{"name":"Behavioural Pharmacology","volume":" ","pages":"187-197"},"PeriodicalIF":1.4,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148418321","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Drug-specific effects of anxiety on high-dose oxycodone: age as a modifier for oxycodone response.","authors":"Longyue Wang, Wei Chai, Bingrong Wang, Qian Ding, Ye Chen, Qin Zheng, Nan Wang, Yu Guo","doi":"10.1097/FBP.0000000000000894","DOIUrl":"10.1097/FBP.0000000000000894","url":null,"abstract":"<p><p>To investigate the association between preoperative anxiety and opioid tolerance in patients undergoing primary hip arthroplasty, focusing on heterogeneity across opioid types and the mechanisms underlying this association, this retrospective cohort study identified 1763 such patients from the Medical Information Mart for Intensive Care IV database. Of these, 198 patients were identified as anxious based on an anxiety diagnosis at admission. Opioid tolerance was assessed by evaluating dosage patterns of morphine, oxycodone, and tramadol. Multivariable logistic regression, Johnson-Neyman, and restricted cubic spline analysis were employed to evaluate the associations and interactions. Transcriptomic data from a rat neuropathic pain model (GSE53897) were used to analyze differential pathways between morphine and oxycodone treatments. Preoperative anxiety was significantly associated with high-dose oxycodone use across model 1 [odds ratio (OR) = 2.025], model 3 (OR = 1.786), and model 4 (OR = 1.679), but not with high-dose morphine or tramadol. Exploratory age analyses revealed that this association exhibited marked age specificity: it persisted only in patients aged less than or equal to 75 years ( P < 0.05) and was nonsignificant in those more than 75 years, with effect strength diminishing with increasing age. Mechanistic analysis revealed different gene profiles and enriched biological pathways between morphine and oxycodone treatment groups, suggesting a molecular basis for treatment heterogeneity. In hip arthroplasty patients, preoperative anxiety was an independent risk factor for oxycodone tolerance, and this effect was age-modulated, significant only in patients aged less than or equal to 75 years. Integrating psychological status and age into pain management strategies deserves consideration in clinical practice.</p>","PeriodicalId":8832,"journal":{"name":"Behavioural Pharmacology","volume":" ","pages":"266-276"},"PeriodicalIF":1.4,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13541607/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148700790","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"N-acetylcysteine: a promising strategy for alleviating damages induced by maternal deprivation in neonatal rats.","authors":"Hoda Shariatmadari, Mohammad Reza Bigdeli, Sepideh Khaksar, Samira Vahidi","doi":"10.1097/FBP.0000000000000889","DOIUrl":"10.1097/FBP.0000000000000889","url":null,"abstract":"<p><p>Maternal deprivation in the postnatal period triggers complex conditions along with impairment in brain development. Research indicates that N-acetyl-L-cysteine (NAC), a nootropic agent, restores glutathione levels for antioxidant protection in neurons. It also balances neurotransmitters and alleviates irritability and anxiety symptoms by reducing oxidative damage. Micro-RNA-146a plays a significant role in neuroinflammation in individuals with autism spectrum disorder, and its expression is upregulated in brain regions involved in cognitive function. This study assessed the effects of NAC on autistic-like behaviors and miRNA146a gene expression in an animal model of maternal deprivation. Rats were divided into four groups: control, NAC-treated, maternal deprivation model, and maternal deprivation model treated with NAC. Rats in the maternal deprivation model groups were deprived of their mothers for 10 consecutive days (3 h/day), starting at postnatal day 1 (PND1) or 24 h after birth. From PND30, the treated groups received gastric gavage of NAC at 150 mg/kg body weight for 30 days. Behavioral tests were performed at PND61, and brain tissue samples were collected to assess miRNA146a gene expression levels using real time PCR. This study indicates that NAC treatment alleviated repetitive and anxiety-like behaviors and improved exploration and sociability in the maternal deprivation model group. It also significantly reduced the overexpression of miRNA146a gene. These findings suggest that NAC may be a promising dietary supplement or therapeutic candidate for behavioral disorders caused by maternal deprivation. The protective effect of NAC likely occurred through the downregulation of miRNA146a gene expression.</p>","PeriodicalId":8832,"journal":{"name":"Behavioural Pharmacology","volume":" ","pages":"289-302"},"PeriodicalIF":1.4,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148418310","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Behavioral and pharmacological validation of the differential reinforcement of low-rate behavior paradigm in non-human primates.","authors":"Casey R Vanderlip, Shelby R Dunn, Jennifer L Basile, Joseph G Wettstein, Jeffrey A Vivian, Courtney Glavis-Bloom","doi":"10.1097/FBP.0000000000000893","DOIUrl":"10.1097/FBP.0000000000000893","url":null,"abstract":"<p><p>Depression remains a leading cause of disability worldwide, yet the predictive validity of many preclinical behavioral assays for antidepressant efficacy remains limited. The differential reinforcement of low-rate behavior (DRL) task has classically been used in rodents to identify antidepressant-like effects, but its utility in non-human primates (NHPs) has not been established. Here, we adapted the DRL task for use in adult male cynomolgus macaques ( Macaca fascicularis ) and evaluated its pharmacological sensitivity and translational relevance across 19 compounds spanning multiple drug classes. Antidepressants, including selective serotonin reuptake inhibitors, serotonin-norepinephrine reuptake inhibitors, noradrenergic reuptake inhibitors, norepinephrine-dopamine reuptake inhibitors, tricyclic antidepressants, monoamine oxidase inhibitors, and phosphodiesterase-4 (PDE4) inhibitors, generally shifted DRL performance in an antidepressant-like direction, increasing reinforcers earned and inter-response times while decreasing response output. In contrast, benzodiazepine and antipsychotic control compounds did not produce a consistent antidepressant-like profile, whereas stimulant effects were mixed, with nicotine and cocaine also producing overlapping antidepressant-like behavioral effects. Importantly, the primate DRL task identified antidepressant-like effects of PDE4 inhibitors while also capturing emesis, a dose-limiting side effect not observable in rodent models. These findings support the primate DRL task as a translationally relevant platform for screening antidepressant-like efficacy, while also highlighting important design considerations for interpreting pharmacological sensitivity in the NHP setting. By modeling behavioral processes implicated in depression, including response inhibition and temporal regulation, this assay offers a unique opportunity to bridge preclinical and clinical antidepressant development with improved sensitivity to both efficacy and tolerability.</p>","PeriodicalId":8832,"journal":{"name":"Behavioural Pharmacology","volume":" ","pages":"221-237"},"PeriodicalIF":1.4,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148668247","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Intermediate doses of d -amphetamine promote perseverative risky choices following the presentation of win-paired cues.","authors":"Connor M Lambert, Karen G Anderson","doi":"10.1097/FBP.0000000000000888","DOIUrl":"10.1097/FBP.0000000000000888","url":null,"abstract":"<p><p>Choosing a relatively large reward with a lower chance of payoff compared with a relatively small reward with a higher chance of payoff can be operationalized as a risky choice. Risky choices are often observed in humans through gambling. Gambling disorder is characterized by excessive gambling that results in detrimental personal, social, and financial outcomes. Clarifying mechanisms that contribute to perseverative gambling could help clarify why problem gambling may occur. The presentation of win-paired cues is suggested to contribute to excessive gambling because of a conditioned-reinforcing function. Stimulant drugs have been shown to enhance conditioned reinforcers and to increase risky choice under certain experimental conditions. The present study was designed to examine how the combined administration of d -amphetamine, a commonly prescribed psychomotor stimulant, and the presentation of win-paired cues on winning and losing trials would impact risky choice patterns in a probability-discounting procedure in Sprague-Dawley rats. d -Amphetamine produced dose-dependent increases in risky choice with or without win-paired cues. Win-paired cues alone did not alter absolute levels of risky choice, but the combination of d -amphetamine and win-paired cues promoted perseveration for the risk-associated response option. This effect was particularly evident following losing trials where the win-paired cue was presented. Results are discussed in the context of electronic gambling machine use, and suggestions for research with more commonly used stimulants are offered.</p>","PeriodicalId":8832,"journal":{"name":"Behavioural Pharmacology","volume":" ","pages":"238-248"},"PeriodicalIF":1.4,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148418395","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Microinjection of morphine into the nucleus accumbens and CA1 modulates pain-related behaviors in an animal model of inflammatory pain in male rats: Erratum.","authors":"Sara Dinparast, Mina Sadeghi, Negar Baharloui, Mohadeseh Ghalandari-Shamami, Batool Ghorbani Yekta, Abbas Haghparast","doi":"10.1097/FBP.0000000000000896","DOIUrl":"https://doi.org/10.1097/FBP.0000000000000896","url":null,"abstract":"","PeriodicalId":8832,"journal":{"name":"Behavioural Pharmacology","volume":"37 5","pages":"304"},"PeriodicalIF":1.4,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148890850","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}