Behavioural Pharmacology最新文献

Temporal pattern of oxycodone self-administration in mice. 小鼠羟考酮自我给药的时间模式。

IF 1.6 4区心理学

Behavioural Pharmacology Pub Date : 2026-06-01 Epub Date: 2026-03-09 DOI: 10.1097/FBP.0000000000000873

Cecilia Barajas, Lukas D Caye, Parker Jones, Kelley F Kitto, George L Wilcox, Carolyn A Fairbanks, Cristina D Peterson

{"title":"Temporal pattern of oxycodone self-administration in mice.","authors":"Cecilia Barajas, Lukas D Caye, Parker Jones, Kelley F Kitto, George L Wilcox, Carolyn A Fairbanks, Cristina D Peterson","doi":"10.1097/FBP.0000000000000873","DOIUrl":"10.1097/FBP.0000000000000873","url":null,"abstract":"Opioids, including oxycodone, are effective at providing analgesia to patients suffering from pain but carry with them the risk of abuse. Rodent models of self-administration are utilized to evaluate the motivational drive of subjects to seek rewarding substances, including the opioid oxycodone, or to evaluate novel therapeutic interventions to prevent seeking of rewarding substances. Self-administration studies examine complex integrated behaviors and many factors contribute to each subject's drive to seek potentially rewarding substances. Here, we report on an often-overlooked factor, namely, the time of day when each subject has access to the rewarding substance. Rodents, including commonly utilized laboratory mice and rats, are active during the dark phase of the circadian cycle, in contrast to the daytime hours when experiments are typically conducted in laboratory settings. In the present study, we observed significantly different oxycodone-seeking behavior between mice who had access to self-administer oxycodone overnight as compared to during the day. Female mice increased their seeking of 30 and 200 mg/l oral oxycodone, while no difference was observed when the concentration was 1000 mg/l, or when only water was offered. These results support that the time of day that subjects can access reward may have a substantial impact on their seeking behaviors, representing an important and overlooked variable in the preclinical modeling of addiction and its interventions.","PeriodicalId":8832,"journal":{"name":"Behavioural Pharmacology","volume":" ","pages":"134-138"},"PeriodicalIF":1.6,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147472543","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Announcement of special issue: 'Behavioural pharmacology of ketamine and psychedelic drugs'. 特刊公告：“氯胺酮和致幻剂的行为药理学”。

IF 1.6 4区心理学

Behavioural Pharmacology Pub Date : 2026-06-01 Epub Date: 2026-05-06 DOI: 10.1097/FBP.0000000000000878

Bart A Ellenbroek, Gernot Riedel

引用次数: 0

The 5-HT 7 receptor antagonist SB-656104A fails to affect breakpoints for cocaine self-administration in male rats. 5-HT7受体拮抗剂SB-656104A不能影响雄性大鼠可卡因自我给药的断点。

IF 1.6 4区心理学

Behavioural Pharmacology Pub Date : 2026-06-01 Epub Date: 2026-05-06 DOI: 10.1097/FBP.0000000000000877

Serena E Rodarte, Perrin S Steel, Amanda M Acuña, Erin K Nagy, Janet L Neisewander, M Foster Olive

{"title":"The 5-HT 7 receptor antagonist SB-656104A fails to affect breakpoints for cocaine self-administration in male rats.","authors":"Serena E Rodarte, Perrin S Steel, Amanda M Acuña, Erin K Nagy, Janet L Neisewander, M Foster Olive","doi":"10.1097/FBP.0000000000000877","DOIUrl":"10.1097/FBP.0000000000000877","url":null,"abstract":"The availability of efficacious pharmacotherapies for the treatment of cocaine use disorders remains a significant unmet societal need. Cocaine exerts its psychoactive effects primarily by inhibiting presynaptic reuptake of monoamine neurotransmitters, including serotonin (5-HT). There are at least 14 different 5-HT receptor subtypes in the brain, and prior studies have shown that the 5-HT 7 receptor subtype plays a role in learning and memory, neural plasticity, impulsivity, alcohol intake, and some behavioral responses to psychostimulants. In this study, we sought to determine the effects of the selective 5-HT 7 antagonist SB-656104A on cocaine self-administration under conditions of increasing behavioral demand using the progressive ratio paradigm. Male rats were trained to self-administer cocaine at a dose of 0.75 mg/kg/infusion. Following acquisition and stabilization of operant responding on a fixed-ratio schedule and subsequent transition to and stabilization under progressive ratio conditions, animals were treated with vehicle or one of three doses of SB-656104A (3, 10, or 20 mg/kg) prior to additional progressive ratio sessions. None of the doses of SB-656104A had any effect on breakpoints for cocaine intake or time to reach breakpoint. These data indicate that blockade of 5-HT 7 receptors with SB-656104A does not alter cocaine intake under conditions of increased behavioral demand. Nonetheless, further studies with other 5-HT 7 ligands should be pursued.","PeriodicalId":8832,"journal":{"name":"Behavioural Pharmacology","volume":" ","pages":"128-133"},"PeriodicalIF":1.6,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147643827","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Microinjection of morphine into the nucleus accumbens and CA1 modulates pain-related behaviors in an animal model of inflammatory pain in male rats. 在雄性大鼠炎症性疼痛动物模型中，伏隔核和CA1微量注射吗啡调节疼痛相关行为。

IF 1.6 4区心理学

Behavioural Pharmacology Pub Date : 2026-04-01 Epub Date: 2026-02-18 DOI: 10.1097/FBP.0000000000000870

Sara Dinparast, Mina Sadeghi, Negar Baharloui, Mohadeseh Ghalandari-Shamami, Batool Ghorbani Yekta, Abbas Haghparast

{"title":"Microinjection of morphine into the nucleus accumbens and CA1 modulates pain-related behaviors in an animal model of inflammatory pain in male rats.","authors":"Sara Dinparast, Mina Sadeghi, Negar Baharloui, Mohadeseh Ghalandari-Shamami, Batool Ghorbani Yekta, Abbas Haghparast","doi":"10.1097/FBP.0000000000000870","DOIUrl":"10.1097/FBP.0000000000000870","url":null,"abstract":"Studies showed that the nucleus accumbens (NAc) and the CA1 of hippocampus involved in multiple functions. Opioid receptors play a critical role in antinociceptive mechanisms. This study explored the involvement of the opioidergic system in the CA1 and NAc regions in modulating the formalin-induced inflammatory nociceptive responses. One hundred and forty-six adult male Wistar rats were unilaterally implanted by separate cannula into the NAc or CA1. The formalin test was employed to evaluate the effect of the microinjections of morphine in NAc or CA1 on inflammatory pain thresholds in 5-min blocks for 60 min. At the first experiment, animals received microinjections of various doses of morphine (2.5, 5, 10, and 25 mmol/0.5 μl) to evaluate its effects as a μ-opioid receptor agonist in the NAc or CA1. At the next experiment, different doses of naloxone were separately administered into the NAc (0.5, 1.5, 5, and 15 mmol/0.5 μl saline) or CA1 (1.5, 5, 15, and 45 mmol/0.5 μl saline) as a nonselective μ-opioid receptor antagonist, before an effective dose of morphine in the NAc (10 mmol/0.5 μl) and CA1 (25 mmol/0.5 μl). The results revealed that intra-NAc and CA1 injections of morphine cause antinociceptive responses in early and late phases of the formalin test. In addition, naloxone injection, administered before the effective dose of morphine, reduced its analgesic effects in both the NAc and CA1. These findings showed that opioidergic neurons exert antinociceptive effects through modulation of the μ-opioid receptor in the NAc and CA1 regions of the brain.","PeriodicalId":8832,"journal":{"name":"Behavioural Pharmacology","volume":" ","pages":"107-116"},"PeriodicalIF":1.6,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146212024","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Evaluation of scopoletin as a potential therapeutic agent in fibromyalgia: evidence from a reserpine-induced mouse model. 评价东莨菪碱作为纤维肌痛的潜在治疗剂：来自利血平诱导小鼠模型的证据。

IF 1.6 4区心理学

Behavioural Pharmacology Pub Date : 2026-04-01 Epub Date: 2026-03-04 DOI: 10.1097/FBP.0000000000000874

Yousra Bseiso, Badriyah S Alotaibi, Alaa A A Aljabali, Omar Gammoh, Mohammad E Rabeh, Ahmad M Rabi, Esam Qnais, Abdelrahim Alqudah

{"title":"Evaluation of scopoletin as a potential therapeutic agent in fibromyalgia: evidence from a reserpine-induced mouse model.","authors":"Yousra Bseiso, Badriyah S Alotaibi, Alaa A A Aljabali, Omar Gammoh, Mohammad E Rabeh, Ahmad M Rabi, Esam Qnais, Abdelrahim Alqudah","doi":"10.1097/FBP.0000000000000874","DOIUrl":"10.1097/FBP.0000000000000874","url":null,"abstract":"Fibromyalgia is a nociplastic pain disorder with musculoskeletal pain. Current treatments are frequently ineffective and produce unwanted side effects. Antinociceptive and neuroprotective activities of scopoletin have not yet been tested in fibromyalgia models. A mouse model of fibromyalgia was created by subcutaneous reserpine (1 mg/kg/d) administration for 3 successive days. Scopoletin treatment was initiated on day 4. Behavioral tests included the tests for mechanical allodynia (von Frey test), thermal hyperalgesia (Hargreaves test), and grip strength, as well as the forced swim test and the open field test. Toxicity was examined with the rotarod test, locomotor activity, catalepsy, body weight, and temperature. Reference drugs were pregabalin and duloxetine. Reserpine-induced significant mechanical allodynia (P < 0.001), thermal hyperalgesia (P < 0.001), muscle weakness (P < 0.001), depressive-like behavior (P < 0.001), and anxiety-like behavior (P < 0.01). Scopoletin (100 mg/kg) significantly reversed mechanical allodynia at 1 h posttreatment (P < 0.001) and improved grip strength (P < 0.01) and thermal latency (P < 0.01). It also reduced immobility in the FST by 37 ± 8% (P < 0.01) and decreased thigmotaxis in the open field test (P < 0.01). Unlike duloxetine, scopoletin significantly attenuated both depressive and anxiety-like behaviors. No significant changes in locomotor coordination, body weight, temperature, or catalepsy were observed (P > 0.05). Scopoletin demonstrated significant antinociceptive, antidepressant, and anxiolytic effects in a reserpine-induced fibromyalgia model.","PeriodicalId":8832,"journal":{"name":"Behavioural Pharmacology","volume":"37 2","pages":"85-96"},"PeriodicalIF":1.6,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147363961","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Sleep effects of hydrophilic and lipophilic statins: a comparative narrative review of clinical and experimental evidence. 亲水和亲脂他汀类药物对睡眠的影响：临床和实验证据的比较叙述综述。

IF 1.6 4区心理学

Behavioural Pharmacology Pub Date : 2026-04-01 Epub Date: 2026-02-26 DOI: 10.1097/FBP.0000000000000872

Sofia Salari, Yasamin Moeinipour, Ghazaleh Elahabadi, Aliasghar Moeinipour, Amir Hooshang Mohammadpour

{"title":"Sleep effects of hydrophilic and lipophilic statins: a comparative narrative review of clinical and experimental evidence.","authors":"Sofia Salari, Yasamin Moeinipour, Ghazaleh Elahabadi, Aliasghar Moeinipour, Amir Hooshang Mohammadpour","doi":"10.1097/FBP.0000000000000872","DOIUrl":"10.1097/FBP.0000000000000872","url":null,"abstract":"Statins inhibit 3-hydroxy-3-methylglutaryl CoA reductase to reduce cardiovascular risk, but may induce neuropsychiatric adverse effects. Sleep disturbances, especially insomnia and vivid dreams, are frequently reported, particularly with lipophilic statins that cross the blood-brain barrier (BBB). However, randomized trials often show minimal objective effects, highlighting the need for integrated evidence. This narrative review synthesized data from human clinical trials, pharmacovigilance databases, animal studies, and molecular investigations to clarify the relationship between statin lipophilicity and sleep outcomes. The evidence remains mixed. Objective polysomnography trials generally show minimal adverse effects or slight improvements in sleep continuity, particularly with the use of hydrophilic statins. In contrast, real-world data and case reports indicate higher rates of insomnia and nightmares with lipophilic agents, particularly simvastatin, likely reflecting pharmacokinetic differences and possible nocebo effects. Lipophilic statins may influence brain cholesterol metabolism and neurotransmission, contributing to subjective sleep disturbances, whereas hydrophilic statins appear to be sleep-neutral. BBB penetration is a key determinant. Future head-to-head trials and individualized prescriptions may optimize the benefit-to-risk balance.","PeriodicalId":8832,"journal":{"name":"Behavioural Pharmacology","volume":" ","pages":"71-84"},"PeriodicalIF":1.6,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147301579","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Wortmannin, a potent phosphatidylinositol 3-kinase inhibitor, suppresses methamphetamine-induced stereotypy and hyperlocomotion in mice. Wortmannin是一种有效的磷脂酰肌醇3-激酶抑制剂，可抑制甲基苯丙胺诱导的小鼠刻板印象和过度运动。

IF 1.6 4区心理学

Behavioural Pharmacology Pub Date : 2026-04-01 Epub Date: 2026-01-26 DOI: 10.1097/FBP.0000000000000871

Takahiro Hamana, Nobue Kitanaka, Frank Scott Hall, Kotoko Amagata, Kentaro Matsuda, Chiaki Morita, Masanori Nakai, Riko Niki, Sho Yuze, Kazuo Tomita, Kento Igarashi, Tomoaki Sato, George R Uhl, Junichi Kitanaka

{"title":"Wortmannin, a potent phosphatidylinositol 3-kinase inhibitor, suppresses methamphetamine-induced stereotypy and hyperlocomotion in mice.","authors":"Takahiro Hamana, Nobue Kitanaka, Frank Scott Hall, Kotoko Amagata, Kentaro Matsuda, Chiaki Morita, Masanori Nakai, Riko Niki, Sho Yuze, Kazuo Tomita, Kento Igarashi, Tomoaki Sato, George R Uhl, Junichi Kitanaka","doi":"10.1097/FBP.0000000000000871","DOIUrl":"10.1097/FBP.0000000000000871","url":null,"abstract":"Phosphatidylinositol 3-kinase (PI3K) (EC2.7.1.137) is an enzyme essential for a variety of biological processes, including inflammation and neuroplasticity. There is a close, positive relationship between these biological functions and the action of psychostimulant drugs such as cocaine and methamphetamine (METH). This suggests that the inhibition of PI3K might regulate METH-induced behavior such as hyperlocomotion and stereotyped behavior. To evaluate the effects of PI3K inhibition on METH-induced behavior, mice were treated with wortmannin, a potent PI3K inhibitor, followed by METH. Horizontal locomotion, vertical rearing, and stereotyped behaviors were measured. In addition, additional experiments were conducted to examine the effects of wortmannin on other aspects of behavior. Pretreatment of mice with wortmannin (3 and 10 mg/kg) significantly inhibited METH (10 mg/kg)-induced stereotyped behavior in a dose-dependent fashion. Stereotyped biting was most robustly reduced by wortmannin, ameliorating the frequency of total stereotypy. Wortmannin (10 but not 3 mg/kg) had a significant inhibitory effect on METH (3 mg/kg)-induced hyperlocomotion. Wortmannin had no effect on other aspects of behavior relevant to emotion or memory. In conclusion, non-glycogen synthase kinase-3β (GSK3β) mediated PI3K signaling pathways appear to contribute to the expression of acute METH effects on locomotion and stereotyped behavior in a manner that is different from PI3K-GSK3β mediated signaling.","PeriodicalId":8832,"journal":{"name":"Behavioural Pharmacology","volume":" ","pages":"97-106"},"PeriodicalIF":1.6,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146040274","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Naltrexone treatment improves anxiety- and depression-like behavior in alcohol-exposed mice. 纳曲酮治疗改善了酒精暴露小鼠的焦虑和抑郁样行为。

IF 1.6 4区心理学

Behavioural Pharmacology Pub Date : 2026-04-01 Epub Date: 2026-02-26 DOI: 10.1097/FBP.0000000000000876

Shuangyi Yang, Liang Tong, Le Zhang, Rongzhen Cui, Xin Lyu, Lin He, Hongyan Liu

{"title":"Naltrexone treatment improves anxiety- and depression-like behavior in alcohol-exposed mice.","authors":"Shuangyi Yang, Liang Tong, Le Zhang, Rongzhen Cui, Xin Lyu, Lin He, Hongyan Liu","doi":"10.1097/FBP.0000000000000876","DOIUrl":"10.1097/FBP.0000000000000876","url":null,"abstract":"Chronic alcohol exposure threatens central nervous system homeostasis, linking to interconnected dysregulated emotional behavior and robust neuroinflammation. Clinically, individuals with alcohol use disorder (AUD) frequently present comorbid anxiety and depression, yet whether naltrexone, an established therapeutic, can ameliorate AUD neuroinflammation remains unclear. This study investigated naltrexone's effects on anxiety- and depressive-like behaviors and neuroinflammatory responses in chronically alcohol-exposed mice. Modified 'Drinking-in-the-Dark' protocol for 4 weeks, which induced alcohol-exposed mice, followed by subcutaneous naltrexone (1 mg/kg/day) or equal-volume saline for 14 days. Open field test, elevated plus maze test, and tail suspension test are used to detect anxiety- and depressive-like behaviors - alcohol exposure-induced anxiety- and depressive-like behaviors, which naltrexone reversed. ELISA and immunofluorescence revealed alcohol-elevated pro-inflammatory cytokines (tumor necrosis factor-α, interleukin-6, and interleukin-1β) in the basolateral amygdala (BLA), prefrontal cortex, and hippocampus, and promoted BLA microglia proliferation. Naltrexone attenuated these neuroinflammatory changes. These findings highlight naltrexone's dual-action potential in addressing behavioral and neuroinflammatory consequences of chronic alcohol exposure, providing experimental evidence for its use in AUD, particularly with comorbid anxiety and depression.","PeriodicalId":8832,"journal":{"name":"Behavioural Pharmacology","volume":" ","pages":"117-125"},"PeriodicalIF":1.6,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12959587/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147301551","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Effects of hydromethylthionine mesylate and rivastigmine in a pharmacological mouse model of Alzheimer's disease. 甲磺酸氢甲基硫氨酸和利瓦斯汀在阿尔茨海默病小鼠模型中的作用。

IF 1.6 4区心理学

Behavioural Pharmacology Pub Date : 2026-02-01 Epub Date: 2025-12-15 DOI: 10.1097/FBP.0000000000000865

Lianne Robinson, Jack Bray, Valeria Melis, Charles R Harrington, Claude M Wischik, Gernot Riedel

{"title":"Effects of hydromethylthionine mesylate and rivastigmine in a pharmacological mouse model of Alzheimer's disease.","authors":"Lianne Robinson, Jack Bray, Valeria Melis, Charles R Harrington, Claude M Wischik, Gernot Riedel","doi":"10.1097/FBP.0000000000000865","DOIUrl":"10.1097/FBP.0000000000000865","url":null,"abstract":"The results from clinical trials have indicated that the tau aggregation inhibitor hydromethylthionine mesylate (HMTM) produces disease-modifying effects in Alzheimer's disease (AD) patients when administered alone, but less of an effect when administered in conjunction with cholinesterase inhibitors (ChEIs). The use of ChEIs for AD has been supported by their ability to reverse scopolamine-induced cognitive impairments in rodents reminiscent of those seen in AD patients. We have previously shown that another tau aggregation inhibitor, methylthionine chloride (MTC), is able to reverse scopolamine-induced deficits in spatial learning and memory. The objective here was to determine the symptomatic efficacy of HMTM and rivastigmine, alone or in combination, in a scopolamine model of AD. Female NMRI mice were treated systemically with scopolamine (0.5 mg/kg) or vehicle in combination with ChEI rivastigmine (0.5 mg/kg) or HMTM (5 or 15 mg/kg) daily before assessment of spatial learning and memory performance in a reference memory task in the water maze. Systemic administration of scopolamine induced significant impairments in the spatial learning of the mice compared to vehicle treatment. These deficits were reversed by treatment with HMTM at both doses and with rivastigmine when given alone. Furthermore, coadministration of rivastigmine with HMTM ameliorated the impairments induced by scopolamine. These findings extend our previous observations with MTC and confirm that HMTM also has a dual mode of action, disease modification through tau aggregation inhibition, but also having symptomatic effects through its normalisation of cholinergic activity.","PeriodicalId":8832,"journal":{"name":"Behavioural Pharmacology","volume":" ","pages":"64-69"},"PeriodicalIF":1.6,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12727062/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145755148","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Reinforcing effects of fentanyl/xylazine mixtures in monkeys responding under a food-versus-drug choice procedure. 芬太尼/噻嗪混合物对猴子在食物与药物选择过程中的强化效应。

IF 1.6 4区心理学

Behavioural Pharmacology Pub Date : 2026-02-01 Epub Date: 2025-12-15 DOI: 10.1097/FBP.0000000000000867

David R Maguire

{"title":"Reinforcing effects of fentanyl/xylazine mixtures in monkeys responding under a food-versus-drug choice procedure.","authors":"David R Maguire","doi":"10.1097/FBP.0000000000000867","DOIUrl":"10.1097/FBP.0000000000000867","url":null,"abstract":"Overdose deaths involving opioids and xylazine, a nonopioid adulterant with sedative, analgesic, and muscle-relaxant properties, have increased dramatically over the past decade. Anecdotal reports suggest xylazine enhances some effects of opioids; however, motivations for their co-use remain unclear. This study examined the reinforcing effects of fentanyl/xylazine mixtures in nonhuman primates responding under a food-versus-drug choice procedure. Rhesus monkeys ( n = 4) responded under a concurrent schedule where responding on one lever delivered a sucrose pellet while responding on the other lever delivered an intravenous infusion of fentanyl (0.032-1.0 µg/kg/infusion) alone or in combination with xylazine (1.0-100 µg/kg/infusion). Unit dose of drug increased across blocks within each session, and the ratio of xylazine to fentanyl (10 : 1, 32 : 1, 100 : 1, and 320 : 1) varied across conditions. Choice of infusions increased and choice of food decreased with increasing unit dose of fentanyl, whether available alone or in combination with xylazine. Xylazine increased the choice of otherwise ineffective doses of fentanyl, resulting in a shift in the fentanyl dose-effect curve leftward 2- to 6-fold across monkeys. Combining xylazine with relatively small doses of fentanyl increased choice of infusions over food compared with fentanyl alone. These data suggest that xylazine enhanced the potency (and possibly effectiveness) of fentanyl to function as a reinforcer, which might contribute to increased potential for abuse.","PeriodicalId":8832,"journal":{"name":"Behavioural Pharmacology","volume":" ","pages":"22-30"},"PeriodicalIF":1.6,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12707576/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145755106","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0