Theobromine synergizes with nicotine to enhance animal motor abilities and cognitive function.

IF 1.6 4区心理学 Q3 BEHAVIORAL SCIENCES

Behavioural Pharmacology Pub Date : 2025-03-20 DOI:10.1097/FBP.0000000000000821

Wenjuan Zhang, Xiao Yang, Baojiang He, Aimin He, Jiehui Li, Xiaojing Zhang, Yanfang Zhang

引用次数: 0

Abstract

The societal consensus on the need for smoking cessation is well-established, yet the number of tobacco users continues to rise. This trend is largely driven by the potent physiological effects of nicotine, which significantly increase the likelihood of tobacco use initiation. Certain compounds found in everyday foods, such as theobromine and caffeine in cocoa products, also exhibit psychostimulatory properties. However, comprehensive studies on the effects of consuming these compounds in the context of tobacco use are limited. This study investigates the role of theobromine, a primary active component in cocoa, in modulating the positive physiological effects of nicotine and explores the underlying mechanisms. Our findings reveal that while low doses of theobromine do not alter nicotine's addictive properties, they amplify its positive physiological effects. Notably, theobromine's impact on nicotine varies significantly between the hippocampus and cerebellum, highlighting region-specific interactions.

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可可碱与尼古丁协同作用，增强动物的运动能力和认知功能。

关于需要戒烟的社会共识已经确立，但烟草使用者的数量仍在继续上升。这一趋势在很大程度上是由尼古丁的强大生理效应所驱动的，尼古丁显著增加了开始使用烟草的可能性。在日常食物中发现的某些化合物，如可可制品中的可可碱和咖啡因，也表现出精神刺激的特性。然而，关于在烟草使用的背景下摄入这些化合物的影响的全面研究是有限的。本研究探讨了可可中的主要活性成分可可碱在调节尼古丁的积极生理作用中的作用，并探讨了其潜在的机制。我们的研究结果表明，虽然低剂量的可可碱不会改变尼古丁的成瘾特性，但它们会放大尼古丁的积极生理效应。值得注意的是，可可碱对尼古丁的影响在海马和小脑之间有显著差异，突出了区域特异性的相互作用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Behavioural Pharmacology 医学-行为科学

CiteScore

3.40

自引率

0.00%

发文量

审稿时长

6-12 weeks

期刊介绍： Behavioural Pharmacology accepts original full and short research reports in diverse areas ranging from ethopharmacology to the pharmacology of schedule-controlled operant behaviour, provided that their primary focus is behavioural. Suitable topics include drug, chemical and hormonal effects on behaviour, the neurochemical mechanisms under-lying behaviour, and behavioural methods for the study of drug action. Both animal and human studies are welcome; however, studies reporting neurochemical data should have a predominantly behavioural focus, and human studies should not consist exclusively of clinical trials or case reports. Preference is given to studies that demonstrate and develop the potential of behavioural methods, and to papers reporting findings of direct relevance to clinical problems. Papers making a significant theoretical contribution are particularly welcome and, where possible and merited, space is made available for authors to explore fully the theoretical implications of their findings. Reviews of an area of the literature or at an appropriate stage in the development of an author’s own work are welcome. Commentaries in areas of current interest are also considered for publication, as are Reviews and Commentaries in areas outside behavioural pharmacology, but of importance and interest to behavioural pharmacologists. Behavioural Pharmacology publishes frequent Special Issues on current hot topics. The editors welcome correspondence about whether a paper in preparation might be suitable for inclusion in a Special Issue.