Behavioural Pharmacology最新文献_第2页

The effects of cannabinoid agonism on auditory discrimination. 大麻素激动作用对听觉辨别的影响。

IF 1.6 4区心理学

Behavioural Pharmacology Pub Date : 2024-12-17 DOI: 10.1097/FBP.0000000000000811

Danielle Nykanen, Hannah Stiffler, Merrick Bay, Cameron Goldie, Shinnyi Chou, Natashia Swalve

{"title":"The effects of cannabinoid agonism on auditory discrimination.","authors":"Danielle Nykanen, Hannah Stiffler, Merrick Bay, Cameron Goldie, Shinnyi Chou, Natashia Swalve","doi":"10.1097/FBP.0000000000000811","DOIUrl":"https://doi.org/10.1097/FBP.0000000000000811","url":null,"abstract":"Recent evidence suggests that cannabis can impair simple auditory processes, and these alterations might be due to cannabinoid agonism. The effect of cannabinoid agonism on relatively complex processes such as auditory discrimination is unknown. The goal of this study was to examine the impact of WIN 55,212-2, a CB1 receptor and CB2 receptor agonism, on auditory discrimination using a go/no-go task. Twenty-two male and female Sprague-Dawley rats were initially trained to lever-press for sucrose to either a pure tone or white noise cue in a go/no-go paradigm, where rats were reinforced for lever-pressing during one cue and punished for lever-pressing during the other auditory cue. After criterion performance was met, rats were then injected with WIN 55,212-2 at 1.2 mg/kg, 3 mg/kg, or a corresponding vehicle (saline) and were tested on auditory discrimination. On day 3, active lever-pressing was higher in both the low- and high-dose WIN groups compared with the saline group. Overall lever-pressing decreased over time in the high-dose WIN 55,212-2 group. There were no effects of the drug on discrimination or errors, suggesting that cannabinoid agonism did not negatively affect auditory discrimination. This is the first study to examine the impact of cannabinoids on the discrimination of tones, finding that, contrary to previous research, the low and high doses of WIN 55,212-2 did not adversely impact auditory-linked behaviors.","PeriodicalId":8832,"journal":{"name":"Behavioural Pharmacology","volume":" ","pages":""},"PeriodicalIF":1.6,"publicationDate":"2024-12-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142880987","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The antidepressant-like activity of ketamine in the rat chronic mild stress model requires activation of cortical 5-HT1A receptors. 氯胺酮在大鼠慢性轻度应激模型中的抗抑郁样活性需要激活皮质5-HT1A受体。

IF 1.6 4区心理学

Behavioural Pharmacology Pub Date : 2024-12-16 DOI: 10.1097/FBP.0000000000000809

Ronan Depoortère, Mariusz Papp, Piotr Gruca, Ewa Litwa, Magdalena Lason, Dominika Biała, Adrian Newman-Tancredi

{"title":"The antidepressant-like activity of ketamine in the rat chronic mild stress model requires activation of cortical 5-HT1A receptors.","authors":"Ronan Depoortère, Mariusz Papp, Piotr Gruca, Ewa Litwa, Magdalena Lason, Dominika Biała, Adrian Newman-Tancredi","doi":"10.1097/FBP.0000000000000809","DOIUrl":"https://doi.org/10.1097/FBP.0000000000000809","url":null,"abstract":"Ketamine displays efficacious rapid-acting antidepressant (RAAD) activity in the rat chronic mild stress (CMS) model. It rapidly reverses anhedonia (CMS-induced sucrose consumption deficit) and attenuates working memory deficit (novel object recognition: NOR) following both systemic (intraperitoneal, i.p.) administration or local administration in the prefrontal cortex (PFC). However, the receptor mechanisms underlying these effects remain to be clarified and may involve activation of serotonin 5-HT1A receptors, as previously found in experiments using the forced swim test. The present study explored the contribution of PFC 5-HT1A receptors in ketamine's RAAD activity in the CMS model. Ketamine (10 mg/kg i.p.) reversed CMS-induced sucrose consumption and working memory (NOR test) deficits. Notably, unilateral PFC microinjections of a 5-HT1A receptor antagonist, WAY-100635 (2 µg), prevented the antidepressant-like and pro-cognitive activity of systemic ketamine on sucrose consumption and working memory deficits. These data indicate that the RAAD activity of ketamine in the rat CMS model requires activation of PFC 5-HT1A receptors. They also reinforce the notion that drugs that directly activate PFC 5-HT1A receptors could constitute an alternative to ketamine as a promising strategy to achieve RAAD effects, with additional benefits against cognitive deficits in depressed patients, but without ketamine's troublesome side-effects and requirements for in-patient supervision.","PeriodicalId":8832,"journal":{"name":"Behavioural Pharmacology","volume":" ","pages":""},"PeriodicalIF":1.6,"publicationDate":"2024-12-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142881072","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Locomotor and discriminative stimulus effects of NBOH hallucinogens in rodents. NBOH致幻剂对啮齿动物的运动和区别刺激作用。

IF 1.6 4区心理学

Behavioural Pharmacology Pub Date : 2024-12-06 DOI: 10.1097/FBP.0000000000000802

Daaniyal D Munir, Ritu A Shetty, Michael B Gatch, Nathalie Sumien, Rebecca D Hill, Jeanne A Priddy, Michael J Forster

{"title":"Locomotor and discriminative stimulus effects of NBOH hallucinogens in rodents.","authors":"Daaniyal D Munir, Ritu A Shetty, Michael B Gatch, Nathalie Sumien, Rebecca D Hill, Jeanne A Priddy, Michael J Forster","doi":"10.1097/FBP.0000000000000802","DOIUrl":"https://doi.org/10.1097/FBP.0000000000000802","url":null,"abstract":"Despite the efforts of the Drug Enforcement Administration to safeguard the public from hazardous analogs of synthetic hallucinogens, these compounds have increasingly been observed in the illicit drug market. Four novel compounds were found to be similar in structure to the previously described 25X-NBOMe synthetic hallucinogens. These four compounds, 25B-NBOH, 25C-NBOH, 25E-NBOH, and 25I-NBOH were evaluated for their ability to modify spontaneous locomotor activity in mice to obtain dose range and time-course information and were then tested for discriminative stimulus effects similar to the prototypical hallucinogen (-)-2,5-dimethoxy-4-methylamphetamine (DOM). All four test compounds decreased locomotor activity. The locomotor depressant effects were similar in magnitude and potency to DOM, but less potent than the 25X-NBOMe compounds in previous reports. 25B-NBOH, 25C-NBOH, and 25E-NBOH fully substituted (≥80%) in DOM-trained rats, whereas 25I-NBOH failed to fully substitute for DOM even at doses that suppressed responding. The discriminative stimulus effects were more potent than those of DOM and the 25X-NBOMe compounds. These findings suggest that three of the four test compounds are most likely to be used as recreational hallucinogens in a similar manner to DOM and the 25X-NBOMe compounds, whereas 25I-NBOH may be less liable to illicit use.","PeriodicalId":8832,"journal":{"name":"Behavioural Pharmacology","volume":" ","pages":""},"PeriodicalIF":1.6,"publicationDate":"2024-12-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142789569","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Evaluation of akathisia in patients receiving selective serotonin reuptake inhibitors/serotonin and noradrenaline reuptake inhibitors. 评估接受选择性 5-羟色胺再摄取抑制剂/5-羟色胺和去甲肾上腺素再摄取抑制剂治疗的患者的抽搐症状。

IF 1.6 4区心理学

Behavioural Pharmacology Pub Date : 2024-12-01 Epub Date: 2024-10-08 DOI: 10.1097/FBP.0000000000000797

Ismail Akgoz, Huseyin Kara, Ozgen Ozcelik, Levent Donmez, Mehmet Eryilmaz, Gul Ozbey

{"title":"Evaluation of akathisia in patients receiving selective serotonin reuptake inhibitors/serotonin and noradrenaline reuptake inhibitors.","authors":"Ismail Akgoz, Huseyin Kara, Ozgen Ozcelik, Levent Donmez, Mehmet Eryilmaz, Gul Ozbey","doi":"10.1097/FBP.0000000000000797","DOIUrl":"10.1097/FBP.0000000000000797","url":null,"abstract":"Akathisia is an underestimated but disturbing extrapyramidal side effect of antidepressants, which could reduce treatment compliance in mood disorders. This study aimed to investigate the frequency and risk factors in patients treated with selective serotonin reuptake inhibitors/serotonin and noradrenaline reuptake inhibitors (SSRI/SNRI). In addition, we assessed the impact of akathisia on the quality of life (QoL). Patients were aged between 18 and 75 years, receiving an SSRI/SNRI for 4-8 weeks, and were diagnosed with anxiety, depression, or obsessive-compulsive disorder. The Barnes Akathisia Rating Scale was used to assess the severity of the akathisia. QoL was evaluated using the Short Form 36 (SF-36) questionnaire. Akathisia was observed in 25% (50/198) of patients. Smokers and younger patients were more frequent among patients with akathisia. Physical functioning, physical role, vitality, and mental health domains of the SF-36 were reduced in the presence of akathisia. In conclusion, our results suggest that akathisia is not a rare side effect of SSRI/SNRI in patients with mood disorders, especially in smokers and younger patients. In addition, akathisia may reduce treatment compliance owing to a reduction in QoL. Further investigations are needed to confirm the risk factors, frequency, and consequences of treatment compliance for SSRI/SNRI-induced akathisia in patients with mood disorders.","PeriodicalId":8832,"journal":{"name":"Behavioural Pharmacology","volume":" ","pages":"460-463"},"PeriodicalIF":1.6,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142380032","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The administration of a phentolamine infusion into the basolateral amygdala enhances long-term memory and diminishes anxiety-like behavior in stressed rats. 向杏仁基底外侧注射酚妥拉明可增强受压大鼠的长期记忆并减少焦虑行为。

IF 1.6 4区心理学

Behavioural Pharmacology Pub Date : 2024-12-01 Epub Date: 2024-10-22 DOI: 10.1097/FBP.0000000000000796

Ali Dehghani, Gholam Hossein Meftahi, Hedayat Sahraei

{"title":"The administration of a phentolamine infusion into the basolateral amygdala enhances long-term memory and diminishes anxiety-like behavior in stressed rats.","authors":"Ali Dehghani, Gholam Hossein Meftahi, Hedayat Sahraei","doi":"10.1097/FBP.0000000000000796","DOIUrl":"10.1097/FBP.0000000000000796","url":null,"abstract":"The basolateral amygdala (BLA) contains adrenergic receptors, which are known to be involved in stress, anxiety, and memory. The objective of this study was to explore whether inhibition of α-adrenergic receptors (by phentolamine, an α-adrenergic receptor antagonist) in the BLA can reduce foot-shock stress-induced anxiety-like behavior, memory deficits, and long-term potentiation (LTP) deficits within the CA1 region of the rat hippocampus. Forty male Wistar rats were assigned to the intact, control, stress (Str), Phent (phentolamine), and Phent + Str groups. Animals were subjected to six shocks on 4 consecutive days, and phentolamine was injected into BLA 20 min before the animals were placed in the foot-shock stress apparatus. Results from the elevated plus maze test (EPM) revealed a reduction in anxiety-like behaviors (by an increased number of entries into the open arm, percentage of time spent in the open arm, and rearing and freezing) among stressed animals upon receiving injections of phentolamine into the BLA. The open-field test results (increased rearing, grooming, and freezing behaviors) were consistent with the EPM test results. Phentolamine infusion into the BLA enhanced spatial memory, reducing errors in finding the target hole and decreasing latency time in the Barnes maze test for stress and nonstress conditions. Injecting phentolamine into the BLA on both sides effectively prevented LTP impairment in hippocampal CA1 neurons after being subjected to foot-shock stress. It has been suggested that phentolamine in the BLA can effectively improve anxiety-like behaviors and memory deficits induced by foot-shock stress.","PeriodicalId":8832,"journal":{"name":"Behavioural Pharmacology","volume":" ","pages":"419-431"},"PeriodicalIF":1.6,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142457075","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Norharmane potentiated anxiolytic- and antidepressant-like responses induced by imipramine and citalopram: an isobologram analysis. Norharmane 可增强丙咪嗪和西酞普兰诱导的抗焦虑和抗抑郁类似反应：异全息图分析。

IF 1.6 4区心理学

Behavioural Pharmacology Pub Date : 2024-12-01 Epub Date: 2024-10-04 DOI: 10.1097/FBP.0000000000000794

Fatemeh Khakpai

{"title":"Norharmane potentiated anxiolytic- and antidepressant-like responses induced by imipramine and citalopram: an isobologram analysis.","authors":"Fatemeh Khakpai","doi":"10.1097/FBP.0000000000000794","DOIUrl":"10.1097/FBP.0000000000000794","url":null,"abstract":"β-carboline compounds display a therapeutic property for treating depression and anxiety behaviors. Imipramine and citalopram play an important role in the modulation of anxiety and depression behaviors. We investigated the effects of norharmane, imipramine, and citalopram on anxiety- and depression-like effects and their interactions. Elevated plus maze and forced swimming test were used for the assessment of anxiety- and depression-like behaviors in male mice. The results revealed that intraperitoneal (i.p.) administration of norharmane (10 mg/kg) increased percentage of open arm time (%OAT) in the elevated plus maze test and decreased immobility time in the forced swimming test, proposing anxiolytic- and antidepressant-like effects. Injection of imipramine (5 mg/kg; i.p.) enhanced %OAT and decreased immobility time, suggesting anxiolytic- and antidepressant-like effects. Moreover, norharmane potentiated the anxiolytic- and antidepressant-like responses induced by imipramine by increasing %OAT and decreasing immobility time. The results revealed additive anxiolytic- and antidepressant-like effects between norharmane and imipramine in mice. Alone, the administration of citalopram (5 mg/kg; i.p.) enhanced %OAT and reduced immobility time, causing anxiolytic- and antidepressant-like effects. When citalopram and norharmane were coinjected, norharmane augmented the anxiolytic- and antidepressant-like effects induced by citalopram by increasing %OAT and reducing immobility time. These results indicated additive anxiolytic- and antidepressant-like effects between norharmane and antidepressant drugs such as imipramine and citalopram on the modulation of anxiety and depression processes in mice.","PeriodicalId":8832,"journal":{"name":"Behavioural Pharmacology","volume":" ","pages":"432-441"},"PeriodicalIF":1.6,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142364232","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

An investigation of economic interactions between social reinforcement and heroin or cocaine in rats. 社会强化与海洛因或可卡因在大鼠体内的经济相互作用的研究。

IF 1.6 4区心理学

Behavioural Pharmacology Pub Date : 2024-12-01 Epub Date: 2024-10-15 DOI: 10.1097/FBP.0000000000000798

Toni Bird, Madeline M Beasley, Emma M Pilz, Sarah Amantini, Kevin Chavez Lopez, Alan Silberberg, David N Kearns

{"title":"An investigation of economic interactions between social reinforcement and heroin or cocaine in rats.","authors":"Toni Bird, Madeline M Beasley, Emma M Pilz, Sarah Amantini, Kevin Chavez Lopez, Alan Silberberg, David N Kearns","doi":"10.1097/FBP.0000000000000798","DOIUrl":"10.1097/FBP.0000000000000798","url":null,"abstract":"The primary goal of the present study was to determine the economic relationship between heroin and social reinforcement in rats: are they substitutes, independents, or complements? In Experiment 1, one group of rats was given a budget of responses that they could allocate between heroin and social reinforcement offered at various combinations of prices. A second group chose between two levers that each resulted in social reinforcement at varying prices when pressed. There was no relationship between the relative allocation of responses between heroin and social reinforcement and changes in their relative prices, indicating that these reinforcers are best viewed as independents. In contrast, when choosing between two sources of social reinforcement, rats increased the allocation of behavior to the cheaper option, confirming that the method used here was sensitive to detecting substitution effects. In Experiment 2, the same method was used to compare one group that chose between heroin and social reinforcement with a second group that chose between cocaine and social reinforcement. The finding that heroin and social reinforcement were independents was replicated. Additionally, there was some evidence that cocaine and social reinforcement were substitutes, at least when the first few minutes of the session were excluded. These results add to our knowledge of how drug and nondrug reinforcers interact in choice situations in rats and may model factors that influence drug use in humans.","PeriodicalId":8832,"journal":{"name":"Behavioural Pharmacology","volume":" ","pages":"442-452"},"PeriodicalIF":1.6,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11527553/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142457074","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Over-the-counter analgesic usage: associations with attentional biases in young women. 使用非处方镇痛药：与年轻女性的注意偏差有关。

IF 1.6 4区心理学

Behavioural Pharmacology Pub Date : 2024-12-01 Epub Date: 2024-10-08 DOI: 10.1097/FBP.0000000000000795

Elise Solbu Roalsø, Sandra Klonteig, Brage Kraft, Siv Skarstein, Eva Hilland, Peyman Mirtaheri, Marianne Aalberg, Rune Jonassen

引用次数: 0

Alcohol consumption and preference in female rats induced by reward downshift reveals sex generality of the modulatory role of physical activity. 奖励下移诱导雌性大鼠的酒精消费和偏好揭示了体育活动调节作用的性别普遍性。

IF 1.6 4区心理学

Behavioural Pharmacology Pub Date : 2024-11-25 DOI: 10.1097/FBP.0000000000000799

Elena Castejón, Emilio Ambrosio, Ricardo Pellón, Carmen Torres

{"title":"Alcohol consumption and preference in female rats induced by reward downshift reveals sex generality of the modulatory role of physical activity.","authors":"Elena Castejón, Emilio Ambrosio, Ricardo Pellón, Carmen Torres","doi":"10.1097/FBP.0000000000000799","DOIUrl":"https://doi.org/10.1097/FBP.0000000000000799","url":null,"abstract":"Increased voluntary consumption of alcohol has been demonstrated in male rats exposed to frustrative reward downshift (the emotional self-medication effect). Access to a wheel for voluntary running abolished this effect in male rats, suggesting an attenuating effect of physical exercise on the negative affect induced by reward downshift and its consequences on drug intake. The present study analyzed this effect in female rats. Sixty-four food-deprived female Wistar rats received 32% sucrose [4% (Experiment 1) or 2% (Experiment 2) in controls] during 10, 5-min preshift sessions followed by 4% (Experiment 1) or 2% (Experiment 2) sucrose during 5 postshift sessions. Immediately after each consummatory session, animals were exposed to a 2-h, two-bottle preference test involving 32% alcohol vs. water. Half of the animals also had access to a running wheel during the preference test. The results showed (a) lower sucrose consumption in the downshifted groups (32-4% and 32-2%) compared to the unshifted controls (4-4% and 2-2%, respectively); (b) higher alcohol preference in downshifted groups without access to a wheel compared with downshifted groups with access to the wheel (Experiments 1 and 2); and (c) increased alcohol intake (g/kg) after experiencing reward downshift in animals without access to the wheel (Experiment 1). Voluntary wheel running thus reduced alcohol intake in female rats experiencing reward downshift. These findings are comparable to previous results reported in male rats and support the usefulness of physical exercise to prevent alcohol self-medication induced by frustrative nonreward.","PeriodicalId":8832,"journal":{"name":"Behavioural Pharmacology","volume":" ","pages":""},"PeriodicalIF":1.6,"publicationDate":"2024-11-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142725334","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Stress and glucocorticoids impair inhibitory avoidance memory retrieval and extinction in male mice: the ameliorative effect of Ginkgo biloba extract. 应激和糖皮质激素损害雄性小鼠的抑制性回避记忆检索和消退：银杏叶提取物的改善作用

IF 1.6 4区心理学

Behavioural Pharmacology Pub Date : 2024-11-20 DOI: 10.1097/FBP.0000000000000800

Neda Alizadeh, Fatemeh Dehbashi, Emad Gholami, Paria Tarahomi, Ali Rashidy-Pour, Abbas Ali Vafaei, Payman Raise-Abdullahi

{"title":"Stress and glucocorticoids impair inhibitory avoidance memory retrieval and extinction in male mice: the ameliorative effect of Ginkgo biloba extract.","authors":"Neda Alizadeh, Fatemeh Dehbashi, Emad Gholami, Paria Tarahomi, Ali Rashidy-Pour, Abbas Ali Vafaei, Payman Raise-Abdullahi","doi":"10.1097/FBP.0000000000000800","DOIUrl":"10.1097/FBP.0000000000000800","url":null,"abstract":"Memory retrieval involves recalling previously consolidated information, while memory extinction refers to the gradual weakening of such memories after recall. Stress and glucocorticoids influence the retrieval and extinction of memory. This study employed a passive avoidance task to examine the impact of acute mild stress and equivalent doses of exogenous corticosterone on fear memory retrieval and extinction in male mice. Subsequently, we investigated the potential therapeutic effects of Ginkgo biloba extract, EGb 761, on memory impairments induced by stress and corticosterone. Corticosterone was administered systemically 30 min before memory reactivation to model glucocorticoid activity during retrieval. Mild acute stress, like the stress levels typically experienced before an exam, was induced through 20-min restraint immediately before reactivation in separate groups. EGb 761 was injected 30 min before corticosterone or stress exposure. Results demonstrated that both corticosterone and acute stress impaired context-specific fear memory retrieval and enhanced subsequent extinction. Pretreatment with EGb 761 inhibited these impairing effects of acute stress and corticosterone on avoidance memory retrieval and extinction. Our findings suggest that the glucocorticoid system and acute stress markedly influence avoidance memory retrieval and extinction. Ginkgo biloba may possess therapeutic and memory-enhancing effects, particularly in stressful situations.","PeriodicalId":8832,"journal":{"name":"Behavioural Pharmacology","volume":" ","pages":""},"PeriodicalIF":1.6,"publicationDate":"2024-11-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142667228","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0