Behavioural Pharmacology最新文献_第3页

The effects of cannabinoid agonism on auditory discrimination. 大麻素激动作用对听觉辨别的影响。

IF 1.6 4区心理学

Behavioural Pharmacology Pub Date : 2025-04-01 Epub Date: 2024-12-17 DOI: 10.1097/FBP.0000000000000811

Danielle Nykanen, Hannah Stiffler, Merrick Bay, Cameron Goldie, Shinnyi Chou, Natashia Swalve

{"title":"The effects of cannabinoid agonism on auditory discrimination.","authors":"Danielle Nykanen, Hannah Stiffler, Merrick Bay, Cameron Goldie, Shinnyi Chou, Natashia Swalve","doi":"10.1097/FBP.0000000000000811","DOIUrl":"10.1097/FBP.0000000000000811","url":null,"abstract":"Recent evidence suggests that cannabis can impair simple auditory processes, and these alterations might be due to cannabinoid agonism. The effect of cannabinoid agonism on relatively complex processes such as auditory discrimination is unknown. The goal of this study was to examine the impact of WIN 55,212-2, a CB 1 receptor and CB 2 receptor agonism, on auditory discrimination using a go/no-go task. Twenty-two male and female Sprague-Dawley rats were initially trained to lever-press for sucrose to either a pure tone or white noise cue in a go/no-go paradigm, where rats were reinforced for lever-pressing during one cue and punished for lever-pressing during the other auditory cue. After criterion performance was met, rats were then injected with WIN 55,212-2 at 1.2 mg/kg, 3 mg/kg, or a corresponding vehicle (saline) and were tested on auditory discrimination. On day 3, active lever-pressing was higher in both the low- and high-dose WIN groups compared with the saline group. Overall lever-pressing decreased over time in the high-dose WIN 55,212-2 group. There were no effects of the drug on discrimination or errors, suggesting that cannabinoid agonism did not negatively affect auditory discrimination. This is the first study to examine the impact of cannabinoids on the discrimination of tones, finding that, contrary to previous research, the low and high doses of WIN 55,212-2 did not adversely impact auditory-linked behaviors.","PeriodicalId":8832,"journal":{"name":"Behavioural Pharmacology","volume":" ","pages":"71-75"},"PeriodicalIF":1.6,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142880987","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The effect of Psilocybe cubensis alkaloids on depressive-like behavior in mice exposed to maternal separation with respect to hippocampal gene expression and DNA methylation of Slc6a4 and Nr3c1. 裸盖菇生物碱对母性分离小鼠抑郁样行为的海马基因表达及Slc6a4和Nr3c1 DNA甲基化的影响

IF 1.6 4区心理学

Behavioural Pharmacology Pub Date : 2025-04-01 Epub Date: 2025-02-20 DOI: 10.1097/FBP.0000000000000813

Eghbal Jasemi, Ali Razmi, Salar Vaseghi, Shayan Amiri, S Mahmoud A Najafi

{"title":"The effect of Psilocybe cubensis alkaloids on depressive-like behavior in mice exposed to maternal separation with respect to hippocampal gene expression and DNA methylation of Slc6a4 and Nr3c1.","authors":"Eghbal Jasemi, Ali Razmi, Salar Vaseghi, Shayan Amiri, S Mahmoud A Najafi","doi":"10.1097/FBP.0000000000000813","DOIUrl":"10.1097/FBP.0000000000000813","url":null,"abstract":"Maternal separation as an early life stress can lead to long-lasting deleterious effects on cognitive and behavioral functions, and the mood state. On the other hand, Psilocybe cubensis (as one of the most well-known magic mushrooms) may be beneficial in the improvement or the treatment of neuropsychiatric disorders. In the present study, we aimed to investigate the effect of P. cubensis extract (PCE) on depressive-like and anxiety-like behaviors, and locomotor activity in mice exposed to early maternal separation. Also, we assessed the expression and methylation level of Slc6a4 and Nr3c1 in the hippocampus. Maternal separation was done in postnatal days (PNDs) 2-18. PCE was intraperitoneally injected at the dose of 20 mg/kg at PND 60, and our tests were done at days 1, 3, and 10, of administration. The results showed that maternal separation significantly induced depressive-like behavior in the forced swim test and anxiety-like behavior in the open field test (OFT). Also, maternal separation decreased locomotor activity in the OFT. In addition, maternal separation decreased the expression and increased the methylation level of both Slc6a4 and Nr3c1 in the hippocampus. However, PCE significantly reversed all these effects. In conclusion, it seems that P. cubensis affects serotonergic signaling via altering Slc6a4 expression and methylation level in the hippocampus of mice. The effect of P. cubensis on Nr3c1 expression and methylation level may also lead to alter the function of the hypothalamus-pituitary-adrenal axis and the stress response in mice exposed to maternal separation.","PeriodicalId":8832,"journal":{"name":"Behavioural Pharmacology","volume":" ","pages":"115-126"},"PeriodicalIF":1.6,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143447898","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Stress and glucocorticoids impair inhibitory avoidance memory retrieval and extinction in male mice: the ameliorative effect of Ginkgo biloba extract. 应激和糖皮质激素损害雄性小鼠的抑制性回避记忆检索和消退：银杏叶提取物的改善作用

IF 1.6 4区心理学

Behavioural Pharmacology Pub Date : 2025-04-01 Epub Date: 2024-11-20 DOI: 10.1097/FBP.0000000000000800

Neda Alizadeh, Fatemeh Dehbashi, Emad Gholami, Paria Tarahomi, Ali Rashidy-Pour, Abbas Ali Vafaei, Payman Raise-Abdullahi

{"title":"Stress and glucocorticoids impair inhibitory avoidance memory retrieval and extinction in male mice: the ameliorative effect of Ginkgo biloba extract.","authors":"Neda Alizadeh, Fatemeh Dehbashi, Emad Gholami, Paria Tarahomi, Ali Rashidy-Pour, Abbas Ali Vafaei, Payman Raise-Abdullahi","doi":"10.1097/FBP.0000000000000800","DOIUrl":"10.1097/FBP.0000000000000800","url":null,"abstract":"Memory retrieval involves recalling previously consolidated information, while memory extinction refers to the gradual weakening of such memories after recall. Stress and glucocorticoids influence the retrieval and extinction of memory. This study employed a passive avoidance task to examine the impact of acute mild stress and equivalent doses of exogenous corticosterone on fear memory retrieval and extinction in male mice. Subsequently, we investigated the potential therapeutic effects of Ginkgo biloba extract, EGb 761, on memory impairments induced by stress and corticosterone. Corticosterone was administered systemically 30 min before memory reactivation to model glucocorticoid activity during retrieval. Mild acute stress, like the stress levels typically experienced before an exam, was induced through 20-min restraint immediately before reactivation in separate groups. EGb 761 was injected 30 min before corticosterone or stress exposure. Results demonstrated that both corticosterone and acute stress impaired context-specific fear memory retrieval and enhanced subsequent extinction. Pretreatment with EGb 761 inhibited these impairing effects of acute stress and corticosterone on avoidance memory retrieval and extinction. Our findings suggest that the glucocorticoid system and acute stress markedly influence avoidance memory retrieval and extinction. Ginkgo biloba may possess therapeutic and memory-enhancing effects, particularly in stressful situations.","PeriodicalId":8832,"journal":{"name":"Behavioural Pharmacology","volume":" ","pages":"97-106"},"PeriodicalIF":1.6,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142667228","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Alcohol consumption and preference in female rats induced by reward downshift reveals sex generality of the modulatory role of physical activity. 奖励下移诱导雌性大鼠的酒精消费和偏好揭示了体育活动调节作用的性别普遍性。

IF 1.6 4区心理学

Behavioural Pharmacology Pub Date : 2025-04-01 Epub Date: 2024-11-25 DOI: 10.1097/FBP.0000000000000799

Elena Castejón, Emilio Ambrosio, Ricardo Pellón, Carmen Torres

{"title":"Alcohol consumption and preference in female rats induced by reward downshift reveals sex generality of the modulatory role of physical activity.","authors":"Elena Castejón, Emilio Ambrosio, Ricardo Pellón, Carmen Torres","doi":"10.1097/FBP.0000000000000799","DOIUrl":"10.1097/FBP.0000000000000799","url":null,"abstract":"Increased voluntary consumption of alcohol has been demonstrated in male rats exposed to frustrative reward downshift (the emotional self-medication effect). Access to a wheel for voluntary running abolished this effect in male rats, suggesting an attenuating effect of physical exercise on the negative affect induced by reward downshift and its consequences on drug intake. The present study analyzed this effect in female rats. Sixty-four food-deprived female Wistar rats received 32% sucrose [4% (Experiment 1) or 2% (Experiment 2) in controls] during 10, 5-min preshift sessions followed by 4% (Experiment 1) or 2% (Experiment 2) sucrose during 5 postshift sessions. Immediately after each consummatory session, animals were exposed to a 2-h, two-bottle preference test involving 32% alcohol vs. water. Half of the animals also had access to a running wheel during the preference test. The results showed (a) lower sucrose consumption in the downshifted groups (32-4% and 32-2%) compared to the unshifted controls (4-4% and 2-2%, respectively); (b) higher alcohol preference in downshifted groups without access to a wheel compared with downshifted groups with access to the wheel (Experiments 1 and 2); and (c) increased alcohol intake (g/kg) after experiencing reward downshift in animals without access to the wheel (Experiment 1). Voluntary wheel running thus reduced alcohol intake in female rats experiencing reward downshift. These findings are comparable to previous results reported in male rats and support the usefulness of physical exercise to prevent alcohol self-medication induced by frustrative nonreward.","PeriodicalId":8832,"journal":{"name":"Behavioural Pharmacology","volume":" ","pages":"144-155"},"PeriodicalIF":1.6,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142725334","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Hesperidin produces antidepressant effects by activating AMPA receptor: enhancing synaptic proteins to promote hippocampal neuronal activities. 橙皮苷通过激活AMPA受体产生抗抑郁作用：增强突触蛋白，促进海马神经元活动。

IF 1.6 4区心理学

Behavioural Pharmacology Pub Date : 2025-04-01 Epub Date: 2024-12-02 DOI: 10.1097/FBP.0000000000000801

Bo Pang, Ting Cao

{"title":"Hesperidin produces antidepressant effects by activating AMPA receptor: enhancing synaptic proteins to promote hippocampal neuronal activities.","authors":"Bo Pang, Ting Cao","doi":"10.1097/FBP.0000000000000801","DOIUrl":"10.1097/FBP.0000000000000801","url":null,"abstract":"Hesperidin treatments reduce depressive symptoms in mouse models of depression, but the mechanism that mediates its antidepressant effects is unclear. This study shows that hesperidin exerts its antidepressant effects by activating α-amino-3-hydroxy-5-methyl-4-isoxazole-propionic acid (AMPA) receptor to promote synaptic and neuronal function in the hippocampus. The optimal dose of hesperidin (10 mg/kg) for the antidepressant potential was determined after 7 consecutive days of treatments, demonstrating decreased latency to eat and increased food consumption in novelty suppressed feeding, and decreased immobility time in tail suspension test (TST). Moreover, the optimal dose also reversed the depressive phenotypes of Institute of Cancer Research mice exposed to chronic unpredictable mild stress (CUMS), including reduced immobility time in the TST and increased sucrose preference in the sucrose preference test. In addition, hesperidin increased the expression of AMPA receptor protein (Glur1) and synaptic proteins (BDNF, PSD95, synapsin1) in the hippocampus of CUMS-exposed mice. Furthermore, inhibition of AMPA receptor activity by NBQX blocked the effect of hesperidin in reversing the depressive phenotypes, upregulated the expression of synaptic proteins (BDNF, PSD95, synapsin1) and cFOS-positive cells in the hippocampus, and increased the number of Ki67-positive cells in the dentate gyrus of the hippocampus of CUMS-exposed mice. These results help to further understand the antidepressant mechanism of hesperidin and provide new ideas for the future development of antidepressant drugs.","PeriodicalId":8832,"journal":{"name":"Behavioural Pharmacology","volume":" ","pages":"127-136"},"PeriodicalIF":1.6,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142749772","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Monlunabant suppresses appetite through a central mechanism. Monlunabant通过中枢机制抑制食欲。

IF 1.6 4区心理学

Behavioural Pharmacology Pub Date : 2025-04-01 Epub Date: 2025-02-18 DOI: 10.1097/FBP.0000000000000818

Priya Mullassaril, Lucy Brodkin, Jesse Brodkin

{"title":"Monlunabant suppresses appetite through a central mechanism.","authors":"Priya Mullassaril, Lucy Brodkin, Jesse Brodkin","doi":"10.1097/FBP.0000000000000818","DOIUrl":"10.1097/FBP.0000000000000818","url":null,"abstract":"This study aimed to determine whether the second-generation cannabinoid receptor subtype 1 (CB 1 ) antagonist, monlunabant - designed to treat obesity by targeting peripheral receptors - might actually exert its effects through CB 1 receptors in the central nervous system. In adult male mice, both monlunabant and rimonabant reduced appetite and antagonized CB 1 agonist-induced hypothermia. Monlunabant was consistently less potent than rimonabant in both appetite suppression and blocking hypothermia. The cannabinoid agonist HU-210 produced profound hypothermia, which was significantly attenuated by 10 mg/kg of either drug and by 3 mg/kg of rimonabant. Similarly, both drugs reduced appetite in food-deprived mice with limited access to preferred food at the same doses that were effective in the hypothermia assay. Lower doses of monlunabant, which likely saturated peripheral receptors, had no effect on appetite. These findings suggest that monlunabant suppresses appetite mainly through antagonism of central CB 1 receptors. Consequently, monlunabant and other second-generation CB 1 antagonists being developed for obesity may carry a similar risk of adverse psychiatric effects, as previously observed with rimonabant.","PeriodicalId":8832,"journal":{"name":"Behavioural Pharmacology","volume":" ","pages":"156-160"},"PeriodicalIF":1.6,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143447937","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Locomotor and discriminative stimulus effects of NBOH hallucinogens in rodents. NBOH致幻剂对啮齿动物的运动和区别刺激作用。

IF 1.6 4区心理学

Behavioural Pharmacology Pub Date : 2025-04-01 Epub Date: 2024-12-06 DOI: 10.1097/FBP.0000000000000802

Daaniyal D Munir, Ritu A Shetty, Michael B Gatch, Nathalie Sumien, Rebecca D Hill, Jeanne A Priddy, Michael J Forster

{"title":"Locomotor and discriminative stimulus effects of NBOH hallucinogens in rodents.","authors":"Daaniyal D Munir, Ritu A Shetty, Michael B Gatch, Nathalie Sumien, Rebecca D Hill, Jeanne A Priddy, Michael J Forster","doi":"10.1097/FBP.0000000000000802","DOIUrl":"10.1097/FBP.0000000000000802","url":null,"abstract":"Despite the efforts of the Drug Enforcement Administration to safeguard the public from hazardous analogs of synthetic hallucinogens, these compounds have increasingly been observed in the illicit drug market. Four novel compounds were found to be similar in structure to the previously described 25X-NBOMe synthetic hallucinogens. These four compounds, 25B-NBOH, 25C-NBOH, 25E-NBOH, and 25I-NBOH were evaluated for their ability to modify spontaneous locomotor activity in mice to obtain dose range and time-course information and were then tested for discriminative stimulus effects similar to the prototypical hallucinogen (-)-2,5-dimethoxy-4-methylamphetamine (DOM). All four test compounds decreased locomotor activity. The locomotor depressant effects were similar in magnitude and potency to DOM, but less potent than the 25X-NBOMe compounds in previous reports. 25B-NBOH, 25C-NBOH, and 25E-NBOH fully substituted (≥80%) in DOM-trained rats, whereas 25I-NBOH failed to fully substitute for DOM even at doses that suppressed responding. The discriminative stimulus effects were more potent than those of DOM and the 25X-NBOMe compounds. These findings suggest that three of the four test compounds are most likely to be used as recreational hallucinogens in a similar manner to DOM and the 25X-NBOMe compounds, whereas 25I-NBOH may be less liable to illicit use.","PeriodicalId":8832,"journal":{"name":"Behavioural Pharmacology","volume":" ","pages":"107-114"},"PeriodicalIF":1.6,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11884793/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142789569","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The effects of xylazine on locomotion and motor behaviour in a planarian model. 二甲肼对涡虫运动和运动行为的影响。

IF 1.6 4区心理学

Behavioural Pharmacology Pub Date : 2025-04-01 Epub Date: 2025-01-23 DOI: 10.1097/FBP.0000000000000814

Ryan Taylor, Eric Denette, Ellie Walter-Goodspeed, Tom Byrne

引用次数: 0

Assessing acute effects of methylphenidate and modafinil on inhibitory capacity, time estimation, attentional lapses, and compulsive-like behavior in rats. 评估哌甲酯和莫达非尼对大鼠抑制能力、时间估计、注意力缺失和强迫样行为的急性影响。

IF 1.6 4区心理学

Behavioural Pharmacology Pub Date : 2025-04-01 Epub Date: 2025-01-29 DOI: 10.1097/FBP.0000000000000815

Rodrigo Sosa, Pedro Espinosa-Villafranca, Pablo Saavedra, María Elena Chávez-Hernández, Perla Leal-Galicia, Gustavo Lago, Florencia Mata, Jesús Mata-Luévanos, Luis Miguel Rodríguez-Serrano, Alejandro Tapia-De-Jesús, Mario Buenrostro-Jáuregui

{"title":"Assessing acute effects of methylphenidate and modafinil on inhibitory capacity, time estimation, attentional lapses, and compulsive-like behavior in rats.","authors":"Rodrigo Sosa, Pedro Espinosa-Villafranca, Pablo Saavedra, María Elena Chávez-Hernández, Perla Leal-Galicia, Gustavo Lago, Florencia Mata, Jesús Mata-Luévanos, Luis Miguel Rodríguez-Serrano, Alejandro Tapia-De-Jesús, Mario Buenrostro-Jáuregui","doi":"10.1097/FBP.0000000000000815","DOIUrl":"10.1097/FBP.0000000000000815","url":null,"abstract":"Medications known as 'cognitive enhancers' are increasingly being consumed off-label by healthy people, raising concerns about their safety. The aim of our study was to profile behavioral performance upon oral administration of methylphenidate (2.5 mg/kg) and modafinil (64 mg/kg) - two popular cognitive enhancers - and upon their discontinuation. We modeled cognitively demanding challenges in neurotypical individuals using a behavioral task where Wistar - Lewis rats had to withhold responses for a specified time to obtain food rewards. This task allowed us to extract several measures of behavioral performance associated with clinically meaningful indices, such as compulsive-like responding, incapacity to wait (impulsivity), time estimation (precision and accuracy), and attentional lapses. Our study design involved examining these behavioral indices in subjects administered either methylphenidate, modafinil, or vehicle. We found that subjects administered modafinil obtained fewer rewards and were less efficient in reward pursuing than the vehicle group; this result was likely due to a drug-induced inability to wait. Upon modafinil discontinuation, subjects earned more rewards but did not entirely catch up with the vehicle group. As for methylphenidate, neither favorable nor unfavorable effects were found in our main analyses. However, an exploratory analysis of changes in behavioral performance within sessions suggested that methylphenidate fostered favorable, yet short-lived, effects. We discuss our results in terms of the risks and cost-benefits of doses above or below the effective dose of cognitive enhancement drugs.","PeriodicalId":8832,"journal":{"name":"Behavioural Pharmacology","volume":" ","pages":"76-96"},"PeriodicalIF":1.6,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143063388","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Theobromine synergizes with nicotine to enhance animal motor abilities and cognitive function. 可可碱与尼古丁协同作用，增强动物的运动能力和认知功能。

IF 1.6 4区心理学

Behavioural Pharmacology Pub Date : 2025-03-20 DOI: 10.1097/FBP.0000000000000821

Wenjuan Zhang, Xiao Yang, Baojiang He, Aimin He, Jiehui Li, Xiaojing Zhang, Yanfang Zhang

引用次数: 0