Behavioural Pharmacology最新文献_第3页

Anxiolytic effects of diazepam in Trinidadian guppies exposed to chemical cues indicating predation risk. 地西泮对特立尼达孔雀鱼暴露于表明捕食风险的化学线索的抗焦虑作用。

IF 1.6 4区心理学

Behavioural Pharmacology Pub Date : 2025-08-15 DOI: 10.1097/FBP.0000000000000847

Adam L Crane, Laurence E A Feyten, Alix J P Brusseau, Félixe Dumaresq Synnott, Indar W Ramnarine, Maud C O Ferrari, Grant E Brown

{"title":"Anxiolytic effects of diazepam in Trinidadian guppies exposed to chemical cues indicating predation risk.","authors":"Adam L Crane, Laurence E A Feyten, Alix J P Brusseau, Félixe Dumaresq Synnott, Indar W Ramnarine, Maud C O Ferrari, Grant E Brown","doi":"10.1097/FBP.0000000000000847","DOIUrl":"https://doi.org/10.1097/FBP.0000000000000847","url":null,"abstract":"The fear of predation is pervasive among vertebrate prey species, being characterized by neurobiological and behavioral changes induced by risk exposure. To understand the acquisition and attenuation of fearful phenotypes, such as dimensions of posttraumatic stress, researchers often use animal models, with prey fishes recently emerging as a nontraditional but promising model. Much is known about fear acquisition in prey fishes such as the Trinidadian guppy, Poecilia reticulata, which inhabit high and low predation sites. Little is known, however, about whether a guppy model shows fear attenuation via therapeutic treatments, such as commonly prescribed anxiolytic drugs, like benzodiazepines. In this study, we used Trinidadian guppies from wild populations to explore the interactive effects of exposure to the anxiolytic drug, diazepam, and exposure to predation risk in the form of injured conspecific cues (i.e. alarm cues) that reliably indicate a predator attack. In Experiment 1, juvenile guppies from both high- and low-predation populations were given a 10-min exposure to diazepam (160 µg/l), resulting in the loss of fear behavior when simultaneously presented with alarm cues. In Experiment 2, we found that a prior 10-min exposure to diazepam (160 µg/l) for adult guppies significantly reduced their subsequent fear behavior toward a separate exposure to alarm cues, revealing that diazepam was having direct effects on guppy cognition rather than simply inactivating the alarm cues via chemical alteration. These anxiolytic effects thus add to the growing support for the predictive validity of prey fishes as animal models for exploring fear attenuation in humans.","PeriodicalId":8832,"journal":{"name":"Behavioural Pharmacology","volume":" ","pages":""},"PeriodicalIF":1.6,"publicationDate":"2025-08-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144991396","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Leptin-dopamine interactions: unveiling the common link between type-2 diabetes and neuropsychiatric comorbidities. 瘦素-多巴胺相互作用：揭示2型糖尿病和神经精神合并症之间的共同联系。

IF 1.6 4区心理学

Behavioural Pharmacology Pub Date : 2025-08-01 Epub Date: 2025-07-02 DOI: 10.1097/FBP.0000000000000820

Allyson Gill, Madison Gill, Rahul Mittal, Khemraj Hirani, Ajay Sharma

{"title":"Leptin-dopamine interactions: unveiling the common link between type-2 diabetes and neuropsychiatric comorbidities.","authors":"Allyson Gill, Madison Gill, Rahul Mittal, Khemraj Hirani, Ajay Sharma","doi":"10.1097/FBP.0000000000000820","DOIUrl":"10.1097/FBP.0000000000000820","url":null,"abstract":"Clinical evidence highlights the central nervous system as a key target in type-2 diabetes-related complications, yet the mechanisms underlying the increased prevalence of mood disorder issues, mainly depression, in patients with diabetes remain poorly understood. Leptin, an adiposity hormone known for its role in energy homeostasis, has been shown to improve insulin sensitivity and regulate blood glucose levels in diabetic populations. Beyond its metabolic effects, leptin also has the potential to mitigate psychiatric complications such as depression and anxiety. Notably, leptin receptors are predominantly expressed on dopamine (DA) neurons in the brain, hinting that leptin may orchestrate DA activity by serving as its endogenous modulator. This review examines the role of leptin as a potential common link between type-2 diabetes and mood disorders, particularly through its effects on DA function. This article proposes defective leptin signaling as a vital mechanism contributing to psychiatric complications and compromised DA functions in type-2 diabetes, highlighting leptin as a promising therapeutic target for addressing metabolic and psychiatric comorbidities.","PeriodicalId":8832,"journal":{"name":"Behavioural Pharmacology","volume":" ","pages":"217-225"},"PeriodicalIF":1.6,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143623293","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Pirfenidone alone or combined with either dulaglutide or empagliflozin protects against fructose-induced Parkinsonian features in rats. 吡非尼酮单独或与杜拉鲁肽或恩格列净联合对大鼠果糖诱导的帕金森特征有保护作用。

IF 1.6 4区心理学

Behavioural Pharmacology Pub Date : 2025-08-01 Epub Date: 2025-06-19 DOI: 10.1097/FBP.0000000000000835

Alaa S Wahba, Hoda E Mohamad, Dina M Abo-Elmatty, Noha M Mesbah, Nehal S Wahba, Ahmed S El Azzazy, Amr T Sakr

{"title":"Pirfenidone alone or combined with either dulaglutide or empagliflozin protects against fructose-induced Parkinsonian features in rats.","authors":"Alaa S Wahba, Hoda E Mohamad, Dina M Abo-Elmatty, Noha M Mesbah, Nehal S Wahba, Ahmed S El Azzazy, Amr T Sakr","doi":"10.1097/FBP.0000000000000835","DOIUrl":"10.1097/FBP.0000000000000835","url":null,"abstract":"This study aimed to investigate and characterize Parkinson's-like behavioral, histological, and biochemical changes induced by feeding fructose (10% w/v) for 24 weeks in rats. Additionally, we aimed to evaluate the potential protective effect of dulaglutide and empagliflozin either individually or combined with pirfenidone on fructose-induced Parkinsonian features. Rats were given 10% w/v fructose solution for 24 weeks and cotreated for the last 4 weeks with either empagliflozin (30 mg/kg/day orally), dulaglutide (0.2 mg/kg/week subcutaneously), pirfenidone (100 mg/kg/day orally), or the combination of the latter with empagliflozin or dulaglutide at the same mentioned doses. Behavioral testing was done at the end of the study period, and brain tissue samples were taken at sacrifice. Fructose-fed rats showed aberrations in cognitive function and motor coordination constellated with loss of substantia nigra neurons, dopamine deficiency, and altered α-synuclein , LRRK2 , and parkin expression. This was associated with insulin resistance, dyslipidemia, enhanced neuroinflammation, and apoptosis. All treatments ameliorated these perturbations with more pronounced effects observed in the combination groups. Current results revealed the neuroprotective potential of dulaglutide, empagliflozin, and pirfenidone against fructose-induced neurobehavioral alterations in rats with an additive effect observed with the combined therapy.","PeriodicalId":8832,"journal":{"name":"Behavioural Pharmacology","volume":" ","pages":"322-336"},"PeriodicalIF":1.6,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144324397","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Slight and hidden hearing loss differentially affect short- and long-term memory in young rats. 轻微和隐蔽性听力损失对幼鼠短期和长期记忆的影响是不同的。

IF 1.6 4区心理学

Behavioural Pharmacology Pub Date : 2025-08-01 Epub Date: 2025-04-17 DOI: 10.1097/FBP.0000000000000828

Joëlle D Jagersma, Sonja J Pyott, Jocelien D A Olivier

{"title":"Slight and hidden hearing loss differentially affect short- and long-term memory in young rats.","authors":"Joëlle D Jagersma, Sonja J Pyott, Jocelien D A Olivier","doi":"10.1097/FBP.0000000000000828","DOIUrl":"10.1097/FBP.0000000000000828","url":null,"abstract":"Mild forms of hearing loss (HL) have been linked to cognitive impairments in children, yet the neurobiological mechanisms underlying this connection remain unclear. Existing research using animal models mostly focuses on more severe levels of HL or investigates only limited aspects of cognition. To gain a broader understanding of how slight/hidden HL affects cognitive behaviors, we induced HL in 4-week-old Wistar rats through noise exposure. Auditory brainstem response measurements confirmed slight and hidden HL, but this auditory impairment did not alter the density of inner hair cells or their synapses with the spiral ganglion (primary auditory) neurons. Both short- and long- term memory formation were tested using the object location, novel object recognition, and social recognition task. Behaviorally, rats with slight/hidden HL performed better than normal hearing (NH) rats during short-term cognition tests. However, long-term memory was impaired in rats with slight/hidden HL when compared to NH controls. Slight/hidden HL also did not consistently affect (social) exploration. In conclusion, this study demonstrates that slight and hidden HL differentially affect short- and long-term cognitive processes in an animal model of early (noise-induced) HL, without affecting (social) exploration. These results suggest a nuanced relationship between slight and hidden HL and both short- and long-term memory formation, underscoring the importance of broader cognitive phenotyping and further investigation into the neurobiological structures linking hearing impairment with cognitive function.","PeriodicalId":8832,"journal":{"name":"Behavioural Pharmacology","volume":" ","pages":"300-311"},"PeriodicalIF":1.6,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12225721/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143962315","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Gabapentin and D-cycloserine alone and in combination with naloxone in methadone-maintained humans responding under a naloxone novel-response discrimination procedure. 加巴喷丁和d -环丝氨酸单独使用以及与纳洛酮联合使用美沙酮在纳洛酮新反应鉴别程序下维持人的反应。

IF 1.6 4区心理学

Behavioural Pharmacology Pub Date : 2025-08-01 Epub Date: 2025-04-08 DOI: 10.1097/FBP.0000000000000823

Lauren R Fitzgerald, Nichole C Stanley, Joseph B Guise, Christopher S Cargile, Michael J Mancino, Alison H Oliveto

{"title":"Gabapentin and D-cycloserine alone and in combination with naloxone in methadone-maintained humans responding under a naloxone novel-response discrimination procedure.","authors":"Lauren R Fitzgerald, Nichole C Stanley, Joseph B Guise, Christopher S Cargile, Michael J Mancino, Alison H Oliveto","doi":"10.1097/FBP.0000000000000823","DOIUrl":"10.1097/FBP.0000000000000823","url":null,"abstract":"The present study examined the impact of the N-type calcium channel blocker gabapentin (GBP) and the partial glycine agonist D-cycloserine (CYC) to attenuate the behavioral effects of naloxone in opioid-dependent humans responding under a naloxone discrimination procedure. Methadone-maintained participants were trained to distinguish between a low dose of naloxone (0.15 mg/70 kg, i.m.; i.e., drug A) and placebo (i.e. drug B) under an instructed novel-response drug discrimination procedure, in which participants identify the drug condition as 'A', 'B', or 'N' (neither A nor B - 'novel'). Once the discrimination was acquired, doses of CYC (0, 500, and 625 mg) and GBP (0, 100, 200, and 400 mg) each alone and in combination with the training dose of naloxone were tested. GBP alone produced only placebo-appropriate responding and did not significantly alter naloxone discrimination when coadministered with naloxone, though it modestly reduced naloxone-induced visual analog scale ratings of drug 'strength'. CYC alone also produced predominantly placebo-appropriate responding and did not modulate naloxone-appropriate responding, but increased ratings of bad effects and decreased ratings of like placebo relative to naloxone alone at the 500 mg dose. These null findings regarding the modulation of naloxone discrimination highlight the limited efficacy of GBP and CYC in this context, contributing to the understanding of pharmacological interactions with opioid antagonists and their potential implications for opioid withdrawal treatment.","PeriodicalId":8832,"journal":{"name":"Behavioural Pharmacology","volume":" ","pages":"265-275"},"PeriodicalIF":1.6,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12226226/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144062018","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Self-synergy antinociceptive effect of diclofenac: effect of peripheral inhibition of nitric oxide synthase. 双氯芬酸的自协同抗伤感受作用：外周抑制一氧化氮合酶的作用。

IF 1.6 4区心理学

Behavioural Pharmacology Pub Date : 2025-08-01 Epub Date: 2025-04-02 DOI: 10.1097/FBP.0000000000000824

Jorge Elías Torres-López, Mayra Martínez-Martínez, Leonor Ivonne Parra-Flores

{"title":"Self-synergy antinociceptive effect of diclofenac: effect of peripheral inhibition of nitric oxide synthase.","authors":"Jorge Elías Torres-López, Mayra Martínez-Martínez, Leonor Ivonne Parra-Flores","doi":"10.1097/FBP.0000000000000824","DOIUrl":"10.1097/FBP.0000000000000824","url":null,"abstract":"This study was conducted to characterize the interaction between the systemic and local peripheral antinociceptive effect of diclofenac, a nonsteroidal anti-inflammatory drug. As well as the effect of local peripheral administration of NG -nitro-L-arginine methyl ester (L-NAME) - a nitric oxide synthesis inhibitor - on the antinociceptive effect of diclofenac. The antinociceptive effect of diclofenac in a fixed-ratio combination of local or intraperitoneal delivery diclofenac was evaluated using the formalin test. Pain-related behavior was quantified in terms of the number of flinches of the injected paw with formalin. Isobolographic analysis was employed to characterize the interaction between the two routes. ED 30 values were estimated for each route, and an isobologram was constructed. Diclofenac and its fixed-ratio combination produced a dose-dependent antinociceptive effect in the second phase, but not in the first phase of the formalin test. The analysis revealed that the simultaneous administration of diclofenac through the two routes was synergistic. Pretreatment of the injured paw with L-NAME partially blocked local, systemic, and simultaneous local and systemic diclofenac-induced antinociception. The obtained results show a synergism after simultaneous administration of diclofenac through two different routes. In addition, it is found that either the local or systemic antinociceptive effect of diclofenac involves the activation of the nitric oxide pathway at the peripheral level.","PeriodicalId":8832,"journal":{"name":"Behavioural Pharmacology","volume":" ","pages":"258-264"},"PeriodicalIF":1.6,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143762529","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

5-HT 2A receptor inverse agonist attenuates morphine withdrawal syndrome and its aversiveness in rats. 5-HT2A受体逆激动剂减轻吗啡戒断综合征及其对大鼠的厌恶。

IF 1.6 4区心理学

Behavioural Pharmacology Pub Date : 2025-08-01 Epub Date: 2025-05-16 DOI: 10.1097/FBP.0000000000000832

Ping-Hsun Tsai, Erica R Morales, Yvonne Y Reed, Hasan Qamar, Emily F Jones, Gopika Saji, Christopher P Ward, Ethan S Burstein, Georgina L Moreno, David H Malin

{"title":"5-HT 2A receptor inverse agonist attenuates morphine withdrawal syndrome and its aversiveness in rats.","authors":"Ping-Hsun Tsai, Erica R Morales, Yvonne Y Reed, Hasan Qamar, Emily F Jones, Gopika Saji, Christopher P Ward, Ethan S Burstein, Georgina L Moreno, David H Malin","doi":"10.1097/FBP.0000000000000832","DOIUrl":"10.1097/FBP.0000000000000832","url":null,"abstract":"This study explored a potential role for the 5-hydroxytryptamine 2A (5-HT 2A ) serotonin receptor in opiate physical dependence. Rats were rendered opiate-dependent by 7 days of continuous subcutaneous (s.c.) morphine sulfate infusion. Pimavanserin is a selective 5-HT 2A receptor inverse agonist in current medical use. A day after termination of drug infusion, rats were injected s.c. with 0.3 or 1.0 mg/kg pimavanserin or saline alone. A nondependent control group was infused with saline alone and injected with saline. One hour after injections, all rats were observed under blind conditions for somatically expressed spontaneous withdrawal signs. While both pimavanserin doses significantly reduced withdrawal signs in the dependent rats, the higher dose reduced those signs to the level exhibited by the nondependent group. In a second experiment, utilizing only nondependent, saline-infused rats, pimavanserin had no significant effect vs. saline injection on overall signs. A third experiment extended these findings to naloxone-precipitated morphine withdrawal. Relative to saline injection, pimavanserin, 1.3 mg/kg s.c., significantly reduced withdrawal signs precipitated by 0.3 mg/kg naloxone 1 h later. This effect was reconfirmed in a separate experiment. The pimavanserin injection also significantly attenuated the aversiveness of morphine withdrawal, as indicated by reduced conditioned avoidance of the chamber where precipitated withdrawal had occurred. These results indicate a major role for the 5-HT 2A receptor in opiate physical dependence and withdrawal syndrome, suggesting this receptor as a potential therapeutic target.","PeriodicalId":8832,"journal":{"name":"Behavioural Pharmacology","volume":" ","pages":"234-245"},"PeriodicalIF":1.6,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12225724/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144109573","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Neurobehavioral manifestations in female rats after intermittent exposure to an anticancer agent, paclitaxel. 雌性大鼠间歇性暴露于抗癌剂紫杉醇后的神经行为表现。

IF 1.6 4区心理学

Behavioural Pharmacology Pub Date : 2025-08-01 Epub Date: 2025-05-20 DOI: 10.1097/FBP.0000000000000833

Deepika Pathak, K P Singh

{"title":"Neurobehavioral manifestations in female rats after intermittent exposure to an anticancer agent, paclitaxel.","authors":"Deepika Pathak, K P Singh","doi":"10.1097/FBP.0000000000000833","DOIUrl":"10.1097/FBP.0000000000000833","url":null,"abstract":"Paclitaxel (PTX), a widely used chemotherapeutic agent, causes both peripheral and central neurotoxicity, leading to significant behavioral impairments. However, inadequate literature is available on PTX-induced neurobehavioral sequelae associated with anxiety, depression, and cognition in adults during and after chemotherapy. Therefore, the present study aimed to investigate neurobehavioral impairments in adult female rats following PTX exposure, with a specific focus on anxiety-like behaviors and cognitive functions such as learning and memory. In this study, we used adult female Wistar rats aged 10-12 weeks (average weight: 180 ± 5 g) and administered clinically relevant therapeutic doses of PTX (1.6 and 3.2 mg/kg body weight) intravenously once weekly for 6 weeks, simulating the clinical chemotherapy regimen. Neurobehavioral assessments were conducted after the first and sixth doses of PTX using validated mazes, including the photoactometer, open-field maze, elevated plus-maze (EPM; for anxiety-like behaviors), and the step-down latency test (SDL; for cognitive performance). Neurobehavioral patterns were recorded using autotracking software (ANY-maze, Stoelting Co., Wood Dale, Illinois, USA). Our findings revealed substantially reduced locomotor activity in the photoactometer, increased anxiety-like behaviors with amplified fear emotionality in the open-field and EPM tests, and memory impairment in the SDL test. These results suggest that the manifestation of anxiogenic and cognitive behavioral changes is associated with the administration of a higher dose (3.2 mg/kg) of PTX. In conclusion, our study indicates that PTX causes significant neurobehavioral impairments in rats after exposure to equivalent therapeutic doses of PTX.","PeriodicalId":8832,"journal":{"name":"Behavioural Pharmacology","volume":" ","pages":"276-289"},"PeriodicalIF":1.6,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144109587","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Role of serotonin 5HT 2C receptors in the discriminative stimulus properties of lorcaserin in male C57BL/6 mice. 5 -羟色胺5HT2C受体在雄性C57BL/6小鼠氯卡色胺鉴别刺激特性中的作用

IF 1.6 4区心理学

Behavioural Pharmacology Pub Date : 2025-08-01 Epub Date: 2025-06-06 DOI: 10.1097/FBP.0000000000000834

Fan Zhang, Katherine L Nicholson, Keith L Shelton, Todd M Hillhouse, Herbert Y Meltzer, Joseph H Porter

{"title":"Role of serotonin 5HT 2C receptors in the discriminative stimulus properties of lorcaserin in male C57BL/6 mice.","authors":"Fan Zhang, Katherine L Nicholson, Keith L Shelton, Todd M Hillhouse, Herbert Y Meltzer, Joseph H Porter","doi":"10.1097/FBP.0000000000000834","DOIUrl":"10.1097/FBP.0000000000000834","url":null,"abstract":"The serotonin 2C receptor (5-HT 2C ) has been investigated as a potential therapeutic target for a variety of psychiatric disorders, as well as the treatment of obesity. A stumbling block in the development of these medications is identifying agonists with selectivity for 5-HT 2C over 5-HT 2A and 5-HT 2B . Lorcaserin (Belviq) is a serotonin 5-HT 2C agonist that was previously marketed as a weight-loss medication but was voluntarily withdrawn from the market because of a small, but an increased risk of serious side effects. The present study examined the discriminative stimulus properties of 2.0 mg/kg lorcaserin in a two-lever drug discrimination assay in male C57BL/6 mice using a fixed ratio 12 reinforcement schedule. A generalization curve with lorcaserin yielded an effective dose 50 (ED 50 ) = 0.56 mg/kg for substitution for the training dose. Lorcaserin produced a rapid onset, but short-acting (~60 min), discriminative stimulus, as full generalization was found as early as 15 min after drug administration. The 5-HT 2C agonist meta-chlorophenylpiperazine fully substituted for lorcaserin with an ED 50 = 0.31 mg/kg, and the 5-HT 2C antagonist SB 242084 significantly blocked lorcaserin-lever responding (maximal effect at 0.25 mg/kg dose). Conversely, the 5-HT 1A agonist 8-hydroxy-2-(di-n-propylamino) tetralin did not substitute for lorcaserin. Thus, lorcaserin's discriminative stimulus appears to be mediated by agonist activity at 5HT 2C receptors in C57BL/6 mice. These results demonstrated that lorcaserin drug discrimination can be trained in C57BL/6 mice and that it is a useful in-vivo assay for the future development of psychotherapeutic drugs for psychiatric disorders with selective 5-HT 2C agonist activity.","PeriodicalId":8832,"journal":{"name":"Behavioural Pharmacology","volume":" ","pages":"337-342"},"PeriodicalIF":1.6,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144233040","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Cannabidiol and cognition: a literature review of human randomized controlled trials. 大麻二酚与认知：人类随机对照试验的文献综述。

IF 1.6 4区心理学

Behavioural Pharmacology Pub Date : 2025-08-01 Epub Date: 2025-06-10 DOI: 10.1097/FBP.0000000000000837

Jyotpal Singh, Chase J Ellingson, M Abdullah Shafiq, Jane Alcorn, J Patrick Neary

{"title":"Cannabidiol and cognition: a literature review of human randomized controlled trials.","authors":"Jyotpal Singh, Chase J Ellingson, M Abdullah Shafiq, Jane Alcorn, J Patrick Neary","doi":"10.1097/FBP.0000000000000837","DOIUrl":"10.1097/FBP.0000000000000837","url":null,"abstract":"Cannabidiol (CBD) is a phytocannabinoid without intoxicating properties. While CBD can improve neurophysiological functions and subjective symptoms, its effect on cognitive function remains unclear. We summarized the available randomized controlled trials investigating CBD administration and cognitive function. A review of the literature was conducted using the following keywords on PubMed/Medline: (cannabis OR cannabidiol OR cannabinoid OR CBD OR Δ 9 -tetrahydrocannabinol OR tetrahydrocannabinol) AND (neurology OR brain OR psychiatric OR neuroscience OR psychology OR cognition) AND (human) AND (randomized controlled trial OR RCT). The search yielded 1038 articles with 36 total included for this literature review. The articles included healthy participants, neurological disease, psychiatric disease, psychosis, paranoia, schizophrenia, and drug-use disorders. Studies with healthy participants included a variety of dosing strategies, suggesting an effect on cognitive function and sleep quality. In Parkinson's disease, 75-300 mg CBD resulted in mild improvements in daily life activities. Decreases in subjective anxiety were found in patients with psychiatric disease using CBD doses ranging from 300 to 400 mg. In patients with psychosis and paranoia, 600 mg CBD showed inconsistent results in cognitive function. In patients with schizophrenia, up to 1000 mg CBD per day had minimal effects on cognition. Finally, up to 800 mg CBD had minimal effects on cognitive function in patients with substance use disorders. The findings are limited by utilization of acute dosing, variations in CBD dose, and different routes of administration. Standardized dosing and CBD formulations are needed to assess its efficacy for improving cognition.","PeriodicalId":8832,"journal":{"name":"Behavioural Pharmacology","volume":" ","pages":"203-216"},"PeriodicalIF":1.6,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144257298","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0