Behavioural Pharmacology最新文献

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Delta opioid receptors on parvalbumin cells are necessary for the convulsant and anxiolytic effects of the delta agonist SNC80. 小白蛋白细胞上的δ阿片受体对于δ受体激动剂SNC80的惊厥和抗焦虑作用是必要的。
IF 1.4 4区 心理学
Behavioural Pharmacology Pub Date : 2026-08-01 Epub Date: 2026-05-29 DOI: 10.1097/FBP.0000000000000882
Marie C Walicki, Matthew R Mueller, Nina Raigosa Garza, Erica S Levitt, John R Traynor, Emily M Jutkiewicz, William T Birdsong
{"title":"Delta opioid receptors on parvalbumin cells are necessary for the convulsant and anxiolytic effects of the delta agonist SNC80.","authors":"Marie C Walicki, Matthew R Mueller, Nina Raigosa Garza, Erica S Levitt, John R Traynor, Emily M Jutkiewicz, William T Birdsong","doi":"10.1097/FBP.0000000000000882","DOIUrl":"10.1097/FBP.0000000000000882","url":null,"abstract":"<p><p>The delta opioid receptor (DOR) is expressed broadly throughout the central and peripheral nervous systems. Activation of DOR by exogenous and endogenous ligands regulates pain, motivation, emotion, and memory, but the cells and neural circuits mediating these behavioral effects remain poorly characterized. Parvalbumin-expressing interneurons (PV-INs) express high levels of DOR transcript ( OPRD1 ) and protein. PV-INs also play a role in pain and emotional processing, suggesting that DOR signaling on PV-INs may modulate these behaviors. To address this question, we used a conditional knockout mouse line (Floxed DOR; PV-cre) to delete DOR from parvalbumin-expressing cells. First, we validated the functional loss of DOR through whole-cell electrophysiology experiments. Next, we characterized baseline behavioral phenotypes and the convulsant, pro-locomotive, and anxiolytic-like behavioral responses induced by the DOR agonist SNC80 in Floxed DOR; PV-Cre mice and their littermate controls. Interestingly, we found that the convulsant and anxiolytic effects of the DOR agonist SNC80 were diminished in Floxed DOR; PV-Cre animals. However, baseline behavioral phenotypes, SNC80-induced spontaneous hyperlocomotion and respiratory stimulation were conserved. These novel findings indicate that the pro-convulsant and anxiolytic effects of DOR agonists are anatomically separable from the locomotor stimulating effects and are dependent on DOR expression on PV-INs.</p>","PeriodicalId":8832,"journal":{"name":"Behavioural Pharmacology","volume":" ","pages":"139-149"},"PeriodicalIF":1.4,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13322383/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148052313","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Effects of gabapentin on heroin and cocaine self-administration in rats. 加巴喷丁对大鼠海洛因和可卡因自我给药的影响。
IF 1.4 4区 心理学
Behavioural Pharmacology Pub Date : 2026-08-01 Epub Date: 2026-07-01 DOI: 10.1097/FBP.0000000000000884
Shawn M Flynn, Han Namgoong, Charles P France
{"title":"Effects of gabapentin on heroin and cocaine self-administration in rats.","authors":"Shawn M Flynn, Han Namgoong, Charles P France","doi":"10.1097/FBP.0000000000000884","DOIUrl":"https://doi.org/10.1097/FBP.0000000000000884","url":null,"abstract":"<p><p>Reports of gabapentin misuse among people with opioid use disorder have increased, as has the presence of gabapentin in opioid overdose deaths. Despite these trends and known interactions between these drugs in other settings (e.g. gabapentin as an 'opioid-sparing' agent), few studies have evaluated the impact of gabapentin on reinforcing effects of opioids. Intravenous self-administration in rats was used to determine whether gabapentin modifies the reinforcing effects of heroin or cocaine. Rats self-administered drugs under a progressive ratio schedule of reinforcement after saline or gabapentin pretreatment. Pretreatment with 32 mg/kg gabapentin increased the number of infusions earned on the ascending limb of the heroin dose-response curve but had no effect on cocaine self-administration. While the magnitude of effect was modest, these data suggest that gabapentin can potentiate the reinforcing effects of opioids and lays the groundwork for future studies characterizing interactions between gabapentinoids and opioids in the context of reinforcement.</p>","PeriodicalId":8832,"journal":{"name":"Behavioural Pharmacology","volume":"37 4","pages":"164-168"},"PeriodicalIF":1.4,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148374516","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
More than an opioid: dissociable analgesic and behavioral effects of kratom in planarians. 超过阿片类药物:可解离镇痛和行为影响的克拉托姆在涡虫。
IF 1.4 4区 心理学
Behavioural Pharmacology Pub Date : 2026-08-01 Epub Date: 2026-07-01 DOI: 10.1097/FBP.0000000000000885
Lindsey S Brasfield, Jeff R Kelly, Haley Daugherty, Morgan Gilmer
{"title":"More than an opioid: dissociable analgesic and behavioral effects of kratom in planarians.","authors":"Lindsey S Brasfield, Jeff R Kelly, Haley Daugherty, Morgan Gilmer","doi":"10.1097/FBP.0000000000000885","DOIUrl":"10.1097/FBP.0000000000000885","url":null,"abstract":"<p><p>Kratom ( Mitragyna speciosa ) is a psychoactive plant with stimulant, sedative, and analgesic properties, yet the mechanisms underlying its behavioral effects remain incompletely understood. In particular, it is unclear whether kratom's effects across behavioral domains are uniformly mediated by opioid receptor signaling. The present study used the planarian flatworm ( Dugesia dorotocephala ) to characterize the effects of kratom and to determine the extent to which these effects are opioid-dependent using the antagonist naloxone. In study 1, kratom produced dose-dependent reductions in locomotion and nociceptive responding, with higher doses nearly abolishing movement. In study 2, kratom significantly reduced locomotion, but this effect was not reversed by naloxone. In contrast, kratom-induced reductions in nociceptive curling were reversed by naloxone, indicating opioid receptor involvement. Together, these findings demonstrate a dissociation between opioid-dependent and opioid-independent effects of kratom, with analgesic effects mediated by opioid receptors and behavioral effects mediated by nonopioid mechanisms. These results highlight the multimodal pharmacology of kratom and support the use of planarians as a tractable model for investigating its neurobehavioral mechanisms.</p>","PeriodicalId":8832,"journal":{"name":"Behavioural Pharmacology","volume":" ","pages":"150-157"},"PeriodicalIF":1.4,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148209942","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Temporal pattern of oxycodone self-administration in mice. 小鼠羟考酮自我给药的时间模式。
IF 1.4 4区 心理学
Behavioural Pharmacology Pub Date : 2026-06-01 Epub Date: 2026-03-09 DOI: 10.1097/FBP.0000000000000873
Cecilia Barajas, Lukas D Caye, Parker Jones, Kelley F Kitto, George L Wilcox, Carolyn A Fairbanks, Cristina D Peterson
{"title":"Temporal pattern of oxycodone self-administration in mice.","authors":"Cecilia Barajas, Lukas D Caye, Parker Jones, Kelley F Kitto, George L Wilcox, Carolyn A Fairbanks, Cristina D Peterson","doi":"10.1097/FBP.0000000000000873","DOIUrl":"10.1097/FBP.0000000000000873","url":null,"abstract":"<p><p>Opioids, including oxycodone, are effective at providing analgesia to patients suffering from pain but carry with them the risk of abuse. Rodent models of self-administration are utilized to evaluate the motivational drive of subjects to seek rewarding substances, including the opioid oxycodone, or to evaluate novel therapeutic interventions to prevent seeking of rewarding substances. Self-administration studies examine complex integrated behaviors and many factors contribute to each subject's drive to seek potentially rewarding substances. Here, we report on an often-overlooked factor, namely, the time of day when each subject has access to the rewarding substance. Rodents, including commonly utilized laboratory mice and rats, are active during the dark phase of the circadian cycle, in contrast to the daytime hours when experiments are typically conducted in laboratory settings. In the present study, we observed significantly different oxycodone-seeking behavior between mice who had access to self-administer oxycodone overnight as compared to during the day. Female mice increased their seeking of 30 and 200 mg/l oral oxycodone, while no difference was observed when the concentration was 1000 mg/l, or when only water was offered. These results support that the time of day that subjects can access reward may have a substantial impact on their seeking behaviors, representing an important and overlooked variable in the preclinical modeling of addiction and its interventions.</p>","PeriodicalId":8832,"journal":{"name":"Behavioural Pharmacology","volume":" ","pages":"134-138"},"PeriodicalIF":1.4,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147472543","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Announcement of special issue: 'Behavioural pharmacology of ketamine and psychedelic drugs'. 特刊公告:“氯胺酮和致幻剂的行为药理学”。
IF 1.6 4区 心理学
Behavioural Pharmacology Pub Date : 2026-06-01 Epub Date: 2026-05-06 DOI: 10.1097/FBP.0000000000000878
Bart A Ellenbroek, Gernot Riedel
{"title":"Announcement of special issue: 'Behavioural pharmacology of ketamine and psychedelic drugs'.","authors":"Bart A Ellenbroek, Gernot Riedel","doi":"10.1097/FBP.0000000000000878","DOIUrl":"https://doi.org/10.1097/FBP.0000000000000878","url":null,"abstract":"","PeriodicalId":8832,"journal":{"name":"Behavioural Pharmacology","volume":"37 3","pages":"127"},"PeriodicalIF":1.6,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147832876","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The 5-HT 7 receptor antagonist SB-656104A fails to affect breakpoints for cocaine self-administration in male rats. 5-HT7受体拮抗剂SB-656104A不能影响雄性大鼠可卡因自我给药的断点。
IF 1.4 4区 心理学
Behavioural Pharmacology Pub Date : 2026-06-01 Epub Date: 2026-05-06 DOI: 10.1097/FBP.0000000000000877
Serena E Rodarte, Perrin S Steel, Amanda M Acuña, Erin K Nagy, Janet L Neisewander, M Foster Olive
{"title":"The 5-HT 7 receptor antagonist SB-656104A fails to affect breakpoints for cocaine self-administration in male rats.","authors":"Serena E Rodarte, Perrin S Steel, Amanda M Acuña, Erin K Nagy, Janet L Neisewander, M Foster Olive","doi":"10.1097/FBP.0000000000000877","DOIUrl":"10.1097/FBP.0000000000000877","url":null,"abstract":"<p><p>The availability of efficacious pharmacotherapies for the treatment of cocaine use disorders remains a significant unmet societal need. Cocaine exerts its psychoactive effects primarily by inhibiting presynaptic reuptake of monoamine neurotransmitters, including serotonin (5-HT). There are at least 14 different 5-HT receptor subtypes in the brain, and prior studies have shown that the 5-HT 7 receptor subtype plays a role in learning and memory, neural plasticity, impulsivity, alcohol intake, and some behavioral responses to psychostimulants. In this study, we sought to determine the effects of the selective 5-HT 7 antagonist SB-656104A on cocaine self-administration under conditions of increasing behavioral demand using the progressive ratio paradigm. Male rats were trained to self-administer cocaine at a dose of 0.75 mg/kg/infusion. Following acquisition and stabilization of operant responding on a fixed-ratio schedule and subsequent transition to and stabilization under progressive ratio conditions, animals were treated with vehicle or one of three doses of SB-656104A (3, 10, or 20 mg/kg) prior to additional progressive ratio sessions. None of the doses of SB-656104A had any effect on breakpoints for cocaine intake or time to reach breakpoint. These data indicate that blockade of 5-HT 7 receptors with SB-656104A does not alter cocaine intake under conditions of increased behavioral demand. Nonetheless, further studies with other 5-HT 7 ligands should be pursued.</p>","PeriodicalId":8832,"journal":{"name":"Behavioural Pharmacology","volume":" ","pages":"128-133"},"PeriodicalIF":1.4,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147643827","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Microinjection of morphine into the nucleus accumbens and CA1 modulates pain-related behaviors in an animal model of inflammatory pain in male rats. 在雄性大鼠炎症性疼痛动物模型中,伏隔核和CA1微量注射吗啡调节疼痛相关行为。
IF 1.4 4区 心理学
Behavioural Pharmacology Pub Date : 2026-04-01 Epub Date: 2026-02-18 DOI: 10.1097/FBP.0000000000000870
Sara Dinparast, Mina Sadeghi, Negar Baharloui, Mohadeseh Ghalandari-Shamami, Batool Ghorbani Yekta, Abbas Haghparast
{"title":"Microinjection of morphine into the nucleus accumbens and CA1 modulates pain-related behaviors in an animal model of inflammatory pain in male rats.","authors":"Sara Dinparast, Mina Sadeghi, Negar Baharloui, Mohadeseh Ghalandari-Shamami, Batool Ghorbani Yekta, Abbas Haghparast","doi":"10.1097/FBP.0000000000000870","DOIUrl":"10.1097/FBP.0000000000000870","url":null,"abstract":"<p><p>Studies showed that the nucleus accumbens (NAc) and the CA1 of hippocampus involved in multiple functions. Opioid receptors play a critical role in antinociceptive mechanisms. This study explored the involvement of the opioidergic system in the CA1 and NAc regions in modulating the formalin-induced inflammatory nociceptive responses. One hundred and forty-six adult male Wistar rats were unilaterally implanted by separate cannula into the NAc or CA1. The formalin test was employed to evaluate the effect of the microinjections of morphine in NAc or CA1 on inflammatory pain thresholds in 5-min blocks for 60 min. At the first experiment, animals received microinjections of various doses of morphine (2.5, 5, 10, and 25 mmol/0.5 μl) to evaluate its effects as a μ-opioid receptor agonist in the NAc or CA1. At the next experiment, different doses of naloxone were separately administered into the NAc (0.5, 1.5, 5, and 15 mmol/0.5 μl saline) or CA1 (1.5, 5, 15, and 45 mmol/0.5 μl saline) as a nonselective μ-opioid receptor antagonist, before an effective dose of morphine in the NAc (10 mmol/0.5 μl) and CA1 (25 mmol/0.5 μl). The results revealed that intra-NAc and CA1 injections of morphine cause antinociceptive responses in early and late phases of the formalin test. In addition, naloxone injection, administered before the effective dose of morphine, reduced its analgesic effects in both the NAc and CA1. These findings showed that opioidergic neurons exert antinociceptive effects through modulation of the μ-opioid receptor in the NAc and CA1 regions of the brain.</p>","PeriodicalId":8832,"journal":{"name":"Behavioural Pharmacology","volume":" ","pages":"107-116"},"PeriodicalIF":1.4,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146212024","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Evaluation of scopoletin as a potential therapeutic agent in fibromyalgia: evidence from a reserpine-induced mouse model. 评价东莨菪碱作为纤维肌痛的潜在治疗剂:来自利血平诱导小鼠模型的证据。
IF 1.4 4区 心理学
Behavioural Pharmacology Pub Date : 2026-04-01 Epub Date: 2026-03-04 DOI: 10.1097/FBP.0000000000000874
Yousra Bseiso, Badriyah S Alotaibi, Alaa A A Aljabali, Omar Gammoh, Mohammad E Rabeh, Ahmad M Rabi, Esam Qnais, Abdelrahim Alqudah
{"title":"Evaluation of scopoletin as a potential therapeutic agent in fibromyalgia: evidence from a reserpine-induced mouse model.","authors":"Yousra Bseiso, Badriyah S Alotaibi, Alaa A A Aljabali, Omar Gammoh, Mohammad E Rabeh, Ahmad M Rabi, Esam Qnais, Abdelrahim Alqudah","doi":"10.1097/FBP.0000000000000874","DOIUrl":"10.1097/FBP.0000000000000874","url":null,"abstract":"<p><p>Fibromyalgia is a nociplastic pain disorder with musculoskeletal pain. Current treatments are frequently ineffective and produce unwanted side effects. Antinociceptive and neuroprotective activities of scopoletin have not yet been tested in fibromyalgia models. A mouse model of fibromyalgia was created by subcutaneous reserpine (1 mg/kg/d) administration for 3 successive days. Scopoletin treatment was initiated on day 4. Behavioral tests included the tests for mechanical allodynia (von Frey test), thermal hyperalgesia (Hargreaves test), and grip strength, as well as the forced swim test and the open field test. Toxicity was examined with the rotarod test, locomotor activity, catalepsy, body weight, and temperature. Reference drugs were pregabalin and duloxetine. Reserpine-induced significant mechanical allodynia (P < 0.001), thermal hyperalgesia (P < 0.001), muscle weakness (P < 0.001), depressive-like behavior (P < 0.001), and anxiety-like behavior (P < 0.01). Scopoletin (100 mg/kg) significantly reversed mechanical allodynia at 1 h posttreatment (P < 0.001) and improved grip strength (P < 0.01) and thermal latency (P < 0.01). It also reduced immobility in the FST by 37 ± 8% (P < 0.01) and decreased thigmotaxis in the open field test (P < 0.01). Unlike duloxetine, scopoletin significantly attenuated both depressive and anxiety-like behaviors. No significant changes in locomotor coordination, body weight, temperature, or catalepsy were observed (P > 0.05). Scopoletin demonstrated significant antinociceptive, antidepressant, and anxiolytic effects in a reserpine-induced fibromyalgia model.</p>","PeriodicalId":8832,"journal":{"name":"Behavioural Pharmacology","volume":"37 2","pages":"85-96"},"PeriodicalIF":1.4,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147363961","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Sleep effects of hydrophilic and lipophilic statins: a comparative narrative review of clinical and experimental evidence. 亲水和亲脂他汀类药物对睡眠的影响:临床和实验证据的比较叙述综述。
IF 1.4 4区 心理学
Behavioural Pharmacology Pub Date : 2026-04-01 Epub Date: 2026-02-26 DOI: 10.1097/FBP.0000000000000872
Sofia Salari, Yasamin Moeinipour, Ghazaleh Elahabadi, Aliasghar Moeinipour, Amir Hooshang Mohammadpour
{"title":"Sleep effects of hydrophilic and lipophilic statins: a comparative narrative review of clinical and experimental evidence.","authors":"Sofia Salari, Yasamin Moeinipour, Ghazaleh Elahabadi, Aliasghar Moeinipour, Amir Hooshang Mohammadpour","doi":"10.1097/FBP.0000000000000872","DOIUrl":"10.1097/FBP.0000000000000872","url":null,"abstract":"<p><p>Statins inhibit 3-hydroxy-3-methylglutaryl CoA reductase to reduce cardiovascular risk, but may induce neuropsychiatric adverse effects. Sleep disturbances, especially insomnia and vivid dreams, are frequently reported, particularly with lipophilic statins that cross the blood-brain barrier (BBB). However, randomized trials often show minimal objective effects, highlighting the need for integrated evidence. This narrative review synthesized data from human clinical trials, pharmacovigilance databases, animal studies, and molecular investigations to clarify the relationship between statin lipophilicity and sleep outcomes. The evidence remains mixed. Objective polysomnography trials generally show minimal adverse effects or slight improvements in sleep continuity, particularly with the use of hydrophilic statins. In contrast, real-world data and case reports indicate higher rates of insomnia and nightmares with lipophilic agents, particularly simvastatin, likely reflecting pharmacokinetic differences and possible nocebo effects. Lipophilic statins may influence brain cholesterol metabolism and neurotransmission, contributing to subjective sleep disturbances, whereas hydrophilic statins appear to be sleep-neutral. BBB penetration is a key determinant. Future head-to-head trials and individualized prescriptions may optimize the benefit-to-risk balance.</p>","PeriodicalId":8832,"journal":{"name":"Behavioural Pharmacology","volume":" ","pages":"71-84"},"PeriodicalIF":1.4,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147301579","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Wortmannin, a potent phosphatidylinositol 3-kinase inhibitor, suppresses methamphetamine-induced stereotypy and hyperlocomotion in mice. Wortmannin是一种有效的磷脂酰肌醇3-激酶抑制剂,可抑制甲基苯丙胺诱导的小鼠刻板印象和过度运动。
IF 1.4 4区 心理学
Behavioural Pharmacology Pub Date : 2026-04-01 Epub Date: 2026-01-26 DOI: 10.1097/FBP.0000000000000871
Takahiro Hamana, Nobue Kitanaka, Frank Scott Hall, Kotoko Amagata, Kentaro Matsuda, Chiaki Morita, Masanori Nakai, Riko Niki, Sho Yuze, Kazuo Tomita, Kento Igarashi, Tomoaki Sato, George R Uhl, Junichi Kitanaka
{"title":"Wortmannin, a potent phosphatidylinositol 3-kinase inhibitor, suppresses methamphetamine-induced stereotypy and hyperlocomotion in mice.","authors":"Takahiro Hamana, Nobue Kitanaka, Frank Scott Hall, Kotoko Amagata, Kentaro Matsuda, Chiaki Morita, Masanori Nakai, Riko Niki, Sho Yuze, Kazuo Tomita, Kento Igarashi, Tomoaki Sato, George R Uhl, Junichi Kitanaka","doi":"10.1097/FBP.0000000000000871","DOIUrl":"10.1097/FBP.0000000000000871","url":null,"abstract":"<p><p>Phosphatidylinositol 3-kinase (PI3K) (EC2.7.1.137) is an enzyme essential for a variety of biological processes, including inflammation and neuroplasticity. There is a close, positive relationship between these biological functions and the action of psychostimulant drugs such as cocaine and methamphetamine (METH). This suggests that the inhibition of PI3K might regulate METH-induced behavior such as hyperlocomotion and stereotyped behavior. To evaluate the effects of PI3K inhibition on METH-induced behavior, mice were treated with wortmannin, a potent PI3K inhibitor, followed by METH. Horizontal locomotion, vertical rearing, and stereotyped behaviors were measured. In addition, additional experiments were conducted to examine the effects of wortmannin on other aspects of behavior. Pretreatment of mice with wortmannin (3 and 10 mg/kg) significantly inhibited METH (10 mg/kg)-induced stereotyped behavior in a dose-dependent fashion. Stereotyped biting was most robustly reduced by wortmannin, ameliorating the frequency of total stereotypy. Wortmannin (10 but not 3 mg/kg) had a significant inhibitory effect on METH (3 mg/kg)-induced hyperlocomotion. Wortmannin had no effect on other aspects of behavior relevant to emotion or memory. In conclusion, non-glycogen synthase kinase-3β (GSK3β) mediated PI3K signaling pathways appear to contribute to the expression of acute METH effects on locomotion and stereotyped behavior in a manner that is different from PI3K-GSK3β mediated signaling.</p>","PeriodicalId":8832,"journal":{"name":"Behavioural Pharmacology","volume":" ","pages":"97-106"},"PeriodicalIF":1.4,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146040274","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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