Behavioural Pharmacology最新文献_第10页

The effect of early and long-term propranolol therapy on learning and memory in mice. 心得安早期和长期治疗对小鼠学习记忆的影响。

IF 1.6 4区心理学

Behavioural Pharmacology Pub Date : 2023-06-01 DOI: 10.1097/FBP.0000000000000725

Mehmet Fatih Orhan, Pelin Tanyeri, Mehmet Emin Büyükokuroğlu, Mustafa Büyükavci

{"title":"The effect of early and long-term propranolol therapy on learning and memory in mice.","authors":"Mehmet Fatih Orhan, Pelin Tanyeri, Mehmet Emin Büyükokuroğlu, Mustafa Büyükavci","doi":"10.1097/FBP.0000000000000725","DOIUrl":"https://doi.org/10.1097/FBP.0000000000000725","url":null,"abstract":"Propranolol is the treatment of choice for infantile hemangioma. We investigated the effects of long-term propranolol use in early infancy on learning and memory later in life in mice. At three weeks of age, mice were randomly divided into six experimental groups. Groups 1 and 2 (controls) received only saline for 21 days. Groups 3 and 4 received propranolol (2.5 mg/kg) for 21 days. Groups 5 and 6 received propranolol (5 mg/kg) for 21 days. Groups 1, 3 and 5 were tested at the end of 21 days of treatment (week 6). However, groups 2, 4 and 6 received a 2-week break and then (week 8) exposed to tests. In the Morris water maze test, propranolol (2.5 and 5 mg/kg) dose-dependently increased the time spent in the target quadrant in mice at weeks 6 and 8. However, propranolol did not affect the swimming speed in both time periods. There were no significant effects of propranolol on the number of errors evaluated during the radial arm maze tests. In conclusion, long-term use of propranolol in early infancy did not disrupt the learning and memory of mice.","PeriodicalId":8832,"journal":{"name":"Behavioural Pharmacology","volume":"34 4","pages":"206-212"},"PeriodicalIF":1.6,"publicationDate":"2023-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9519621","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Development of a nicotine aerosol self-administration model in rats and the effects of e-liquid flavors. 尼古丁气雾剂大鼠自我给药模型的开发及电子液体口味的影响。

IF 1.6 4区心理学

Behavioural Pharmacology Pub Date : 2023-04-01 Epub Date: 2023-01-30 DOI: 10.1097/FBP.0000000000000717

Julie A Marusich, Matthew I Palmatier

{"title":"Development of a nicotine aerosol self-administration model in rats and the effects of e-liquid flavors.","authors":"Julie A Marusich, Matthew I Palmatier","doi":"10.1097/FBP.0000000000000717","DOIUrl":"10.1097/FBP.0000000000000717","url":null,"abstract":"Electronic nicotine delivery system (ENDS) use is maintained by the positive reinforcement associated with preferred flavors. These flavors become conditioned reinforcers through pairings with primary reinforcers. This study sought to extend prior research with intravenous nicotine self-administration and develop a more ecologically valid preclinical model of aerosol self-administration in rats that incorporated flavors paired with sucrose. Rats were first trained to respond for oral sucrose with or without raspberry flavor to establish the flavor as a conditioned reinforcer for some groups. Rats were then exposed to aerosol self-administration. All groups responded for raspberry-flavored aerosol with or without nicotine. Rats responded more for raspberry flavored sucrose than unflavored sucrose. Despite raspberry increasing responding for sucrose, the flavor did not function as a conditioned reinforcer during aerosol self-administration and did not increase responding for nicotine. Throughout the aerosol self-administration phase, most groups responded more on the active than inactive lever, and some groups increased their response when the fixed ratio value was increased. At the end of the study, rats in nicotine groups earned similar or fewer aerosol deliveries than rats in vehicle groups. Aerosolized nicotine did not function as a reinforcer in this study, whereas aerosolized raspberry flavor may have maintained self-administration. Further preclinical investigation is needed to articulate the impact of flavors on ENDS use and whether they offset some aversive effects of nicotine or maintain responding on their own. If flavors reduce some aversive effects of self-administered nicotine, then policies to regulate flavors in e-liquids are prudent.","PeriodicalId":8832,"journal":{"name":"Behavioural Pharmacology","volume":"34 2-3","pages":"141-153"},"PeriodicalIF":1.6,"publicationDate":"2023-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10006336/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10583532","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Maternal treatment with aripiprazole prevents the development of a valproic acid-induced autism-like phenotype in juvenile male mice. 母体用阿立哌唑治疗可防止幼年雄性小鼠丙戊酸诱导的自闭症样表型的发展。

IF 1.6 4区心理学

Behavioural Pharmacology Pub Date : 2023-04-01 DOI: 10.1097/FBP.0000000000000718

Emerson de Oliveira Ferreira, Jéssica Maria Pessoa Gomes, Kelly Rose Tavares Neves, Francisco Arnaldo Viana Lima, Glauce Socorro de Barros Viana, Geanne Matos de Andrade

{"title":"Maternal treatment with aripiprazole prevents the development of a valproic acid-induced autism-like phenotype in juvenile male mice.","authors":"Emerson de Oliveira Ferreira, Jéssica Maria Pessoa Gomes, Kelly Rose Tavares Neves, Francisco Arnaldo Viana Lima, Glauce Socorro de Barros Viana, Geanne Matos de Andrade","doi":"10.1097/FBP.0000000000000718","DOIUrl":"https://doi.org/10.1097/FBP.0000000000000718","url":null,"abstract":"Autism spectrum disorder (ASD) describes a heterogeneous group of neurodevelopmental conditions characterized by deficits in social communication and repetitive behaviors. Aripiprazole (APZ) is an atypical antipsychotic that can safeguard mice against autism-like behavior induced by valproic acid (VPA). In the present study, we examined the effects of maternal treatment with APZ (10 mg/kg) in juvenile mice prenatally exposed to VPA on neurodevelopmental behaviors, social interactions, communication, and working memory, as well as synaptophysin (SYP), synaptosomal-associated protein, 25 kDa (SNAP-25) and microtubule-associated protein 2 (MAP-2) expression in the medial prefrontal cortex (mPFC) and cell viability in the hippocampus. In addition, to evaluate possible APZ interference with the anticonvulsant properties of VPA on pentylenetetrazole (PTZ)-induced seizures were evaluated. Maternal treatment with APZ significantly prevented body weight loss, self-righting, eye-opening, social interactions, social communication, and working memory deficits in mice prenatally exposed to VPA. Additionally, the decrease in the SYP, SNAP-25, and MAP-2 expressions in the mPFC and cell death in the hippocampus was prevented by APZ. Furthermore, APZ (10 mg/kg) did not interfere with the anticonvulsant effect of VPA (15 mg/kg) in animals with PTZ-induced seizures. These findings indicate that maternal treatment with APZ in pregnant mice exposed to VPA protects animals against the ASD-like behavioral phenotype, and this effect may be related, at least in part, to synaptic plasticity and neuronal protection in the PFC and hippocampus. APZ may serve as an effective pharmacological therapeutic target against autistic behaviors in the VPA animal model of ASD, which should be further investigated to verify its clinical relevance.","PeriodicalId":8832,"journal":{"name":"Behavioural Pharmacology","volume":"34 2-3","pages":"154-168"},"PeriodicalIF":1.6,"publicationDate":"2023-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10601250","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Modeling spontaneous opioid withdrawal in male and female outbred mice using traditional endpoints and hyperalgesia. 使用传统终点和痛觉过敏方法对雄性和雌性远交种小鼠的自发性阿片类药物戒断进行建模。

IF 1.6 4区心理学

Behavioural Pharmacology Pub Date : 2023-04-01 DOI: 10.1097/FBP.0000000000000714

Abigail L Brewer, Christina C Lewis, Liudmyla Eggerman, Alexis Blokker, John A Burkland, Megan Johnsen, Raymond M Quock

{"title":"Modeling spontaneous opioid withdrawal in male and female outbred mice using traditional endpoints and hyperalgesia.","authors":"Abigail L Brewer, Christina C Lewis, Liudmyla Eggerman, Alexis Blokker, John A Burkland, Megan Johnsen, Raymond M Quock","doi":"10.1097/FBP.0000000000000714","DOIUrl":"https://doi.org/10.1097/FBP.0000000000000714","url":null,"abstract":"Opioid withdrawal significantly impacts drug dependence cycles as hyperalgesia associated with withdrawal is often a reason for continued drug use. Animal models of addiction are important tools for studying how drug dependence and withdrawal impact not only normal neurocircuitry but also the effectiveness of potential treatments for dependence and withdrawal. We conducted a study of the time course of spontaneous morphine withdrawal in outbred male and female mice that can be used to examine sex differences in male and female mice using both traditional somatic endpoints and mechanical hyperalgesia as an endpoint of withdrawal. Male and female national institute of health (NIH) Swiss mice were made dependent upon morphine using an escalating dosing schedule. Injections were stopped after 5 days. Withdrawal behavior was assessed at time intervals up to 106 h after the final injection. Numbers of forepaw tremors, wet-dog shakes, jumps and other behaviors were scored to create a global score. Paw pressure readings were then also taken to track changes in sensitivity to a painful stimulus over time. Male and female mice had approximately similar withdrawal severity peaking at 24 h after the final injection as measured by composite global scores. Females did exhibit an earlier and greater frequency of tremors than males. Although males and females showed similar hyperalgesia during withdrawal, females recovered faster. Spontaneous opioid withdrawal peaking at 24 h was demonstrated in male and female NIH Swiss mice. We also successfully demonstrated that hyperalgesia is an endpoint that varies over the course of withdrawal.","PeriodicalId":8832,"journal":{"name":"Behavioural Pharmacology","volume":"34 2-3","pages":"112-122"},"PeriodicalIF":1.6,"publicationDate":"2023-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10289427","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 3

Effects of methylphenidate on impulsive choice and delay aversion in Lewis rats. 哌醋甲酯对路易斯大鼠冲动选择和延迟厌恶的影响

IF 1.6 4区心理学

Behavioural Pharmacology Pub Date : 2023-04-01 Epub Date: 2023-01-30 DOI: 10.1097/FBP.0000000000000719

Kelsey Panfil, Robert Small, Kimberly Kirkpatrick

{"title":"Effects of methylphenidate on impulsive choice and delay aversion in Lewis rats.","authors":"Kelsey Panfil, Robert Small, Kimberly Kirkpatrick","doi":"10.1097/FBP.0000000000000719","DOIUrl":"10.1097/FBP.0000000000000719","url":null,"abstract":"Attention-deficit/hyperactivity disorder (ADHD), a common behavioral disorder in children and young adults, is characterized by symptoms of impulsivity, inattention, and hyperactivity. The purpose of this study was to evaluate the Lewis rat strain as a model of ADHD by testing their impulsive choices. Lewis rats were compared to their source strain, the Wistar rat, on an impulsive choice task. Rats completed the tasks on and off methylphenidate, a commonly prescribed medication for ADHD. Off methylphenidate, Lewis rats made more impulsive choices than Wistar rats. Analyses of acquisition of choice behavior suggested that both strains were able to discriminate reward sizes, but Lewis rats still chose the smaller-sooner option more than the larger-later (LL) option when the delays to reward were the same. This may be due to an aversion to the LL lever, which was associated with the longest delays to reward. Higher doses of methylphenidate increased LL choices in Lewis rats but decreased LL choices in Wistar rats. Altogether, these results suggest Lewis rats may be a viable model for ADHD in individuals whose symptoms are characterized by impulsive choices.","PeriodicalId":8832,"journal":{"name":"Behavioural Pharmacology","volume":"34 2-3","pages":"169-Btii"},"PeriodicalIF":1.6,"publicationDate":"2023-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10006322/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10289431","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Announcement of two Special Issues:'Behavioural pharmacology of pain' and 'Sex differences in behavioural pharmacology'. 宣布两期特刊:“疼痛的行为药理学”和“行为药理学的性别差异”。

IF 1.6 4区心理学

Behavioural Pharmacology Pub Date : 2023-04-01 DOI: 10.1097/FBP.0000000000000726

引用次数: 0

Ketamine as a pharmacological tool for the preclinical study of memory deficit in schizophrenia. 氯胺酮作为精神分裂症记忆缺陷临床前研究的药理学工具。

IF 1.6 4区心理学

Behavioural Pharmacology Pub Date : 2023-04-01 DOI: 10.1097/FBP.0000000000000689

José Eduardo Suárez Santiago, Gabriel Roldán Roldán, Ofir Picazo

{"title":"Ketamine as a pharmacological tool for the preclinical study of memory deficit in schizophrenia.","authors":"José Eduardo Suárez Santiago, Gabriel Roldán Roldán, Ofir Picazo","doi":"10.1097/FBP.0000000000000689","DOIUrl":"https://doi.org/10.1097/FBP.0000000000000689","url":null,"abstract":"Schizophrenia is a serious neuropsychiatric disorder characterized by the presence of positive symptoms (hallucinations, delusions, and disorganization of thought and language), negative symptoms (abulia, alogia, and affective flattening), and cognitive impairment (attention deficit, impaired declarative memory, and deficits in social cognition). Dopaminergic hyperactivity seems to explain the positive symptoms, but it does not completely clarify the appearance of negative and cognitive clinical manifestations. Preclinical data have demonstrated that acute and subchronic treatment with NMDA receptor antagonists such as ketamine (KET) represents a useful model that resembles the schizophrenia symptomatology, including cognitive impairment. This latter has been explained as a hypofunction of NMDA receptors located on the GABA parvalbumin-positive interneurons (near to the cortical pyramidal cells), thus generating an imbalance between the inhibitory and excitatory activity in the corticomesolimbic circuits. The use of behavioral models to explore alterations in different domains of memory is vital to learn more about the neurobiological changes that underlie schizophrenia. Thus, to better understand the neurophysiological mechanisms involved in cognitive impairment related to schizophrenia, the purpose of this review is to analyze the most recent findings regarding the effect of KET administration on these processes.","PeriodicalId":8832,"journal":{"name":"Behavioural Pharmacology","volume":"34 2-3","pages":"80-91"},"PeriodicalIF":1.6,"publicationDate":"2023-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10288895","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

Effects of Ketanserin, M100907 and Olanzapine on hallucinogenic like action induced by 2,5-dimethoxy-4-methylamphetamine. 凯坦色林、M100907和奥氮平对2,5-二甲氧基-4-甲基苯丙胺致幻作用的影响

IF 1.6 4区心理学

Behavioural Pharmacology Pub Date : 2023-04-01 Epub Date: 2022-12-27 DOI: 10.1097/FBP.0000000000000693

Kaixi Li, Xiaoyan Liu, Mei Zhang, Ruibin Su

{"title":"Effects of Ketanserin, M100907 and Olanzapine on hallucinogenic like action induced by 2,5-dimethoxy-4-methylamphetamine.","authors":"Kaixi Li, Xiaoyan Liu, Mei Zhang, Ruibin Su","doi":"10.1097/FBP.0000000000000693","DOIUrl":"10.1097/FBP.0000000000000693","url":null,"abstract":"2,5-dimethoxy-4-methylamphetamine (DOM) is a kind of hallucinogen of phenylalkylamine. Psychedelic effects mainly include audiovisual synesthesia, complex imagery, disembodiment etc. that can impair control and cognition leading to adverse consequences such as suicide. By now, there are no specific drugs regarding the management of classic hallucinogen use clinically. We evaluated the effects of three 5-HT 2A receptor antagonists ketanseirn, M100907 and olanzapine on hallucination-like behavior in therapeutic and preventive administration with male C57BL/6J mice. Two models were used to evaluate the therapeutic potential of antagonists, one is head-twitch response (HTR) and the other is locomotion. Effects of ketanserin, M100907 and olanzapine on DOM-induced HTR were studied in preventive and therapeutic administration, respectively. In the preventive administration, the ID 50 values of ketanseirn, M100907 and olanzapine were 0.4 mg/kg, 0.005 mg/kg and 0.25 mg/kg. In the therapeutic administration, the ID 50 values of ketanseirn, M100907 and olanzapine were 0.04 mg/kg, 0.005 mg/kg and 0.03 mg/kg. Secondly, locomotor activity induced by DOM was performed to further evaluate the efficacy of three compounds. In locomotion, M100907(0.005 mg/kg) whenever in preventive or therapeutic administration, reduced the increase of movement distance induced by DOM. Although ketanserin (0.4 mg/kg) in the preventive administration also decreased the movement distance induced by DOM, it was alone administrated to influence the locomotor activity. Through HTR and locomotion, we compared the efficacy and latent side effects of ketanserin, M100907 and olanzapine against hallucinogenic like action induced by DOM. Our study provided additional experimental evidence on specific therapeutic drugs against hallucinogenic behavior induce by representative hallucinogen DOM.","PeriodicalId":8832,"journal":{"name":"Behavioural Pharmacology","volume":"34 2-3","pages":"92-100"},"PeriodicalIF":1.6,"publicationDate":"2023-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10289429","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Antidepressant-like effect of acute dose of Naringin involves suppression of NR1 and activation of protein kinase A/cyclic adenosine monophosphate response element-binding protein/brain-derived neurotrophic factor signaling in hippocampus. 急性剂量柚皮苷的抗抑郁样作用涉及抑制NR1和激活海马蛋白激酶A/环磷酸腺苷反应元件结合蛋白/脑源性神经营养因子信号通路。

IF 1.6 4区心理学

Behavioural Pharmacology Pub Date : 2023-04-01 DOI: 10.1097/FBP.0000000000000713

Guangyao Wang, Haixia Yang, Wenren Zuo, Xiaoyun Mei

{"title":"Antidepressant-like effect of acute dose of Naringin involves suppression of NR1 and activation of protein kinase A/cyclic adenosine monophosphate response element-binding protein/brain-derived neurotrophic factor signaling in hippocampus.","authors":"Guangyao Wang, Haixia Yang, Wenren Zuo, Xiaoyun Mei","doi":"10.1097/FBP.0000000000000713","DOIUrl":"https://doi.org/10.1097/FBP.0000000000000713","url":null,"abstract":"Naringin (Nr) has been identified to have antidepressant-like effects through repeated treatment. However, the underlying mechanism of the rapid antidepressant-like effects of Nr was still unclear. The present study used behavioral tests, classic depressive model and pharmacological methods to reveal the rapid antidepressant-like potential of Nr. We found that a single dose of Nr (20 mg/kg) produced antidepressant-like action after 2 h in the tail suspension test (TST) and forced swimming test (FST). Moreover, ketamine-like effects were also demonstrated by using the chronic mild stress model (CMS) and learned helplessness (LH), and the results showed that Nr reversed all behavioral defects, TST, FST, source preference test (SPT) in CMS, and LH testing, TST, FST in LH model, at 2 h after a single administration. In addition, Nr (20 mg/kg) could improve the abnormal expressions of NMDA receptor NR1 and PKA/CREB/BDNF pathway in hippocampus 2 h after a single administration in CMS mice. Further investigation revealed that activation of NMDA receptors by NMDA (750 mg/kg) could block the antidepressant effects of acute administration of Nr (20 mg/kg). However, the inhibition of NMDA receptors by MK-801 (0.05 mg/kg) promoted the subdose of Nr (10 mg/kg) to have antidepressant effect, which was similar to the effective dose Nr (20 mg/kg). Taken together, acute dose of Nr produces rapid antidepressant-like action, and the underlying mechanism could be through inhibiting NMDA receptors in the hippocampus.","PeriodicalId":8832,"journal":{"name":"Behavioural Pharmacology","volume":"34 2-3","pages":"101-111"},"PeriodicalIF":1.6,"publicationDate":"2023-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10226129","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Mitragynine, a primary constituent of kratom reinstates morphine-seeking behaviour in rats. 米特拉金，一种主要成分的kratom恢复吗啡寻求行为在大鼠。

IF 1.6 4区心理学

Behavioural Pharmacology Pub Date : 2023-04-01 DOI: 10.1097/FBP.0000000000000715

Rima Atria Japarin, Norsyifa Harun, Zurina Hassan, Mohammed Shoaib

{"title":"Mitragynine, a primary constituent of kratom reinstates morphine-seeking behaviour in rats.","authors":"Rima Atria Japarin, Norsyifa Harun, Zurina Hassan, Mohammed Shoaib","doi":"10.1097/FBP.0000000000000715","DOIUrl":"https://doi.org/10.1097/FBP.0000000000000715","url":null,"abstract":"Mitragynine (MG) is a pharmacologically active alkaloid derived from the leaves of Mitragyna speciosa Korth (Kratom). This plant has sparked significant interest as a potential alternative treatment for managing opioid dependence and withdrawal due to its opioid-like pharmacological effects. However, whether MG exposure would trigger opioid-seeking behaviour following abstinence has not been investigated. The present study examined the effects of MG priming on morphine-seeking behaviour in rats. Male Sprague-Dawley rats were initially trained to intravenously self-administer morphine (0.5 mg/kg/infusion) under a fixed ratio-3 schedule of reinforcement. Removal of both morphine infusions and drug-associated cues led to the subsequent extinction of the drug-seeking behaviour. Tests of reinstatement were made following exposure to a randomised order of intraperitoneal injections of MG (3, 10 and 30 mg/kg), morphine (5 mg/kg) and vehicle. Significant levels of drug-seeking behaviour were observed following extended access to morphine self-administration, which was extinguished following removal of morphine and cues indicative of morphine-seeking behaviour, supporting the relapse model. The present finding demonstrated that MG priming in a dose of 10 mg/kg resulted in the reinstatement of morphine-seeking behaviour, whereas the higher MG dose (30 mg/kg) tested suppressed the seeking response. This study indicated that exposure to a low MG dose may increase the likelihood of relapsing to opioids, suggesting that the potential of MG as a treatment for opioid management merits further scientific assessment of its ability to trigger relapse to opioid abuse.","PeriodicalId":8832,"journal":{"name":"Behavioural Pharmacology","volume":"34 2-3","pages":"123-130"},"PeriodicalIF":1.6,"publicationDate":"2023-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10289901","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1