Chronic caffeine decreases anxiety-like behavior in the marble burying task in adolescent rats.

IF 1.6 4区心理学 Q3 BEHAVIORAL SCIENCES

Behavioural Pharmacology Pub Date : 2024-04-24 DOI:10.1097/FBP.0000000000000777

Gwi Park, Sarah M Turgeon

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引用次数: 0

Abstract

Exposure to chronic caffeine during adolescence has been shown to produce decreased anxiety-like behaviors in rats as well as decreased immobility in the forced swim test (FST) suggesting an antidepressant-like effect. The effects of chronic caffeine on anxiety, however, have been found to be test-dependent and sexually dimorphic. In addition, decreased immobility in the FST has been argued to reflect a shift toward active coping behavior as opposed to an antidepressant-like effect. In order to further characterize the effects of adolescent caffeine exposure, the present experiment assessed the effects of caffeine on marble burying behavior in a two-zone marble burying task. There was no difference in the amount of time rats spent in the two zones failing to support a shift in coping strategy. Caffeine-exposed rats spent less time engaged in marble burying activity and buried slightly fewer marbles, suggesting an anxiolytic effect of caffeine. In addition, caffeine treated rats spent less time engaged in nondirected burying and slightly more time actively engaging with the marbles; however, these effects appeared to be sexually dimorphic as they were driven by larger changes in the females. Overall, these results support an anxiolytic effect of adolescent caffeine, with female behavior appearing to be more affected by caffeine than males.

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慢性咖啡因会减少青少年大鼠在埋大理石任务中的焦虑行为

研究表明，大鼠在青春期长期接触咖啡因会减少焦虑行为，并减少强迫游泳试验（FST）中的不动性，这表明咖啡因具有类似抗抑郁剂的作用。然而，研究发现，慢性咖啡因对焦虑的影响依赖于测试，并且具有性别双态性。此外，有人认为 FST 中固定性的降低反映了向积极应对行为的转变，而不是类似抗抑郁的效果。为了进一步确定青少年暴露于咖啡因的影响，本实验评估了咖啡因对两区大理石掩埋任务中大理石掩埋行为的影响。大鼠在两个区域所花费的时间没有差异，这不支持应对策略的转变。暴露于咖啡因的大鼠参与埋弹珠活动的时间较短，埋弹珠的数量也略有减少，这表明咖啡因具有抗焦虑作用。此外，经过咖啡因处理的大鼠参与非定向掩埋活动的时间更少，而主动接触弹珠的时间略有增加；不过，这些影响似乎具有性别二态性，因为它们在雌性大鼠中的变化更大。总体而言，这些结果支持青春期咖啡因的抗焦虑作用，雌性行为似乎比雄性受咖啡因的影响更大。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Behavioural Pharmacology 医学-行为科学

CiteScore

3.40

自引率

0.00%

发文量

审稿时长

6-12 weeks

期刊介绍： Behavioural Pharmacology accepts original full and short research reports in diverse areas ranging from ethopharmacology to the pharmacology of schedule-controlled operant behaviour, provided that their primary focus is behavioural. Suitable topics include drug, chemical and hormonal effects on behaviour, the neurochemical mechanisms under-lying behaviour, and behavioural methods for the study of drug action. Both animal and human studies are welcome; however, studies reporting neurochemical data should have a predominantly behavioural focus, and human studies should not consist exclusively of clinical trials or case reports. Preference is given to studies that demonstrate and develop the potential of behavioural methods, and to papers reporting findings of direct relevance to clinical problems. Papers making a significant theoretical contribution are particularly welcome and, where possible and merited, space is made available for authors to explore fully the theoretical implications of their findings. Reviews of an area of the literature or at an appropriate stage in the development of an author’s own work are welcome. Commentaries in areas of current interest are also considered for publication, as are Reviews and Commentaries in areas outside behavioural pharmacology, but of importance and interest to behavioural pharmacologists. Behavioural Pharmacology publishes frequent Special Issues on current hot topics. The editors welcome correspondence about whether a paper in preparation might be suitable for inclusion in a Special Issue.