The effects of high fat diet consumption on morphine-induced constipation.

IF 1.6 4区心理学 Q3 BEHAVIORAL SCIENCES

Behavioural Pharmacology Pub Date : 2025-08-01 Epub Date: 2025-04-29 DOI:10.1097/FBP.0000000000000831

Nina M Beltran, Thelma I Garcia, Gabriela M Naime, Vanessa Minervini, Katherine M Serafine

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引用次数: 0

Abstract

Opioids, prescribed for pain relief or as maintenance therapies for opioid use disorder, induce constipation, which can lead to medication compliance issues. However, it is not known how dietary manipulation might impact opioid-induced constipation. To test the hypothesis that eating a high fat diet exacerbates opioid-induced constipation, male and female Sprague-Dawley rats ( n = 8/diet/sex) were fed either a low fat (standard) diet, a high fat/high carbohydrate diet, or a ketogenic diet. Rats were injected with either saline or morphine (1-10 mg/kg) and constipation was measured by counting fecal boli hourly for 6 h. Morphine-induced comparable constipation in all groups; however, rats eating a high fat/high carbohydrate or ketogenic diet produced significantly less feces following injections of saline or morphine as compared to rats eating a standard diet ( P < 0.05). Dietary considerations might be important for patients prescribed opioid medications.

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高脂肪饮食对吗啡引起的便秘的影响。

阿片类药物用于缓解疼痛或作为阿片类药物使用障碍的维持疗法，会引起便秘，从而导致药物依从性问题。然而，尚不清楚饮食控制如何影响阿片类药物引起的便秘。为了验证高脂肪饮食会加剧阿片类药物引起的便秘的假设，雄性和雌性Sprague-Dawley大鼠（n = 8/饮食/性别）分别被喂食低脂肪（标准）饮食、高脂肪/高碳水化合物饮食或生酮饮食。给大鼠注射生理盐水或吗啡（1-10 mg/kg），每小时计数粪肠数，连续6 h测量便秘情况。吗啡诱导各组便秘比较；然而，喂食高脂肪/高碳水化合物或生酮饮食的大鼠在注射生理盐水或吗啡后产生的粪便明显少于喂食标准饮食的大鼠（P < 0.05）。饮食方面的考虑可能对处方阿片类药物的患者很重要。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Behavioural Pharmacology 医学-行为科学

CiteScore

3.40

自引率

0.00%

发文量

审稿时长

6-12 weeks

期刊介绍： Behavioural Pharmacology accepts original full and short research reports in diverse areas ranging from ethopharmacology to the pharmacology of schedule-controlled operant behaviour, provided that their primary focus is behavioural. Suitable topics include drug, chemical and hormonal effects on behaviour, the neurochemical mechanisms under-lying behaviour, and behavioural methods for the study of drug action. Both animal and human studies are welcome; however, studies reporting neurochemical data should have a predominantly behavioural focus, and human studies should not consist exclusively of clinical trials or case reports. Preference is given to studies that demonstrate and develop the potential of behavioural methods, and to papers reporting findings of direct relevance to clinical problems. Papers making a significant theoretical contribution are particularly welcome and, where possible and merited, space is made available for authors to explore fully the theoretical implications of their findings. Reviews of an area of the literature or at an appropriate stage in the development of an author’s own work are welcome. Commentaries in areas of current interest are also considered for publication, as are Reviews and Commentaries in areas outside behavioural pharmacology, but of importance and interest to behavioural pharmacologists. Behavioural Pharmacology publishes frequent Special Issues on current hot topics. The editors welcome correspondence about whether a paper in preparation might be suitable for inclusion in a Special Issue.