Cortex最新文献

{"title":"Oral applause sign in progressive supranuclear palsy.","authors":"Kazuto Katsuse, Kazuo Kakinuma, Nobuko Kawakami, Shoko Ota, Ai Kawamura, Nanayo Ogawa, Chifumi Iseki, Masashi Hamada, Tatsushi Toda, Shigenori Kanno, Minoru Matsuda, Kyoko Suzuki","doi":"10.1016/j.cortex.2024.11.021","DOIUrl":"https://doi.org/10.1016/j.cortex.2024.11.021","url":null,"abstract":"<p><p>The applause sign (AS) is a recognized phenomenon observed in progressive supranuclear palsy (PSP) and other neurological conditions where individuals produce over three claps following a request to clap only thrice after a demonstration. In this study, we introduced a novel linguistic phenomenon termed the oral applause sign (OAS) associated with the AS. The OAS is characterized by increased repetition counts of Japanese repetitive onomatopoeic words, such as uttering \"pata-pata-pata\" instead of the expected \"pata-pata.\" We identified this phenomenon in a patient with PSP exhibiting the AS and mild apraxia of speech. In addition, we developed the three-\"pata\" test, instructing the patient to say \"pata\" only thrice after demonstration without any semantic context, and reproduced the phenomenon of the additional increase of \"pata\" verbalization. The core feature of OAS is an inability to limit the count when repeating a small number of syllables continuously, similar to the inability to stop clapping. The shared features between the OAS and AS suggest potential overlapping mechanisms involving the dysfunction of the frontal lobe and subcortical structures and possibly, apraxia of speech. Considering that the OAS is triggered purely by repetition and unlikely to be affected by semantic content, it might be observable in Japanese and other languages. Longitudinal studies with larger cohorts across various neurodegenerative diseases and languages may elucidate the underlying mechanisms of the OAS and confirm its specificity to PSP, thus improving the generalizability and clinical relevance of the findings.</p>","PeriodicalId":10758,"journal":{"name":"Cortex","volume":" ","pages":""},"PeriodicalIF":3.2,"publicationDate":"2024-12-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142926832","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Lateral peri-hand bias affects the horizontal but not the vertical distribution of attention.","authors":"Noah Britt, Hong-Jin Sun","doi":"10.1016/j.cortex.2024.12.009","DOIUrl":"https://doi.org/10.1016/j.cortex.2024.12.009","url":null,"abstract":"<p><p>It has been demonstrated that humans exhibit an attention bias towards the lower visual field (e.g., faster target detection for targets appearing below eye level). This bias has been interpreted as reflecting the visual motor demand in near space below eye level. In this study, we examined whether this spatial bias could be affected by participants' hand position at the time of testing. Specifically, if the hand position is held at eye level at the time of target detection, whether the bias toward the lower visual field would be reduced if the bias is directly related to the motor demand at the time of testing. Using a modified spatial cueing paradigm, in Experiment 1, we found a downward bias in reaction time measures and cueing effects in a target detection task. In Experiment 2, using the same stimulus used in Experiment 1, we compared attention performance when participants' dominant (right) hand was positioned close to the right side of the visual display with the conditions where their hand was in their laps. We revealed that despite an influence on the horizontal distribution of attention (lateral peri-hand effect), the downward bias in attention remained regardless of the hand position. This revealed that lateral peri-hand manipulation is insufficient to override the attention advantage for stimuli appearing in the lower visual field.</p>","PeriodicalId":10758,"journal":{"name":"Cortex","volume":"183 ","pages":"251-260"},"PeriodicalIF":3.2,"publicationDate":"2024-12-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142926843","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Structure-function relationships in the human aging brain: An account of cross-sectional and longitudinal multimodal neuroimaging studies.","authors":"Grégoria Kalpouzos, Jonas Persson","doi":"10.1016/j.cortex.2024.12.004","DOIUrl":"https://doi.org/10.1016/j.cortex.2024.12.004","url":null,"abstract":"<p><p>The patterns of brain activation and functional connectivity, task-related and task-free, as a function of age have been well documented over the past 30 years. However, the aging brain undergoes structural changes that are likely to affect the functional properties of the brain. The relationship between brain structure and function started to be investigated more recently. Brain structure and brain function can influence behavioral outcomes independently, and several studies highlight independent contribution of structure and function on cognition. Here, a central assumption is that brain structure also affects behavior indirectly through its influence on brain function. In such a model, structure supports function. Although findings generally suggest that structure may indeed influence function, the direction of the associations, the variability in terms of regional effects and age windows when associations are observed vary greatly. Also, a certain number of studies highlight the independent contribution of structure and function on cognition. A critical aspect of studying aging is the necessity of longitudinal designs, allowing to observe true aging effects - as compared with age differences in cross-sectional designs. This review aims to give an updated account on research dealing with multimodal neuroimaging in aging, and more specifically on the links between structure and function and associated cognitive outcomes, putting in parallel findings from cross-sectional and longitudinal studies. Additionally, we discuss potential mechanisms by which age-related changes in structure may affect function, but also factors (sample characteristics, methodology) that may contribute to the heterogeneity of the findings and the lack of consensus on the associations between structure, function, cognition and aging.</p>","PeriodicalId":10758,"journal":{"name":"Cortex","volume":"183 ","pages":"274-289"},"PeriodicalIF":3.2,"publicationDate":"2024-12-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142930759","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Age-based stereotype threat effects: From the laboratory to the clinical setting.","authors":"Isabelle Régner, Pascal Huguet","doi":"10.1016/j.cortex.2024.12.006","DOIUrl":"https://doi.org/10.1016/j.cortex.2024.12.006","url":null,"abstract":"<p><p>Age-Based Stereotype Threat (ABST) adversely affects older adults' memory performance by inducing anxiety and interfering thoughts related to negative stereotypes about aging and memory decline. While well-documented in laboratory settings, the relevance of ABST in real-life clinical contexts remains underexplored. This narrative review examines the effects of ABST and its implications for cognitive aging, emphasizing the importance of addressing ABST in clinical settings. We review key laboratory findings and the limited studies that simulate clinical environments, highlighting their methodological limitations. The review underscores the need for further research involving actual patients, tested within real clinical setting and using appropriate interventions to reduce ABST. Proactive interventions such as educational debriefing and expressive writing, are promising methods adapted to clinical settings. By enhancing our understanding and mitigation of ABST in clinical practice, we can improve the accuracy and reliability of neuropsychological assessments, leading to better diagnostic outcomes for older adults.</p>","PeriodicalId":10758,"journal":{"name":"Cortex","volume":"183 ","pages":"261-273"},"PeriodicalIF":3.2,"publicationDate":"2024-12-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142930758","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Does the stop-signal P3 reflect inhibitory control?","authors":"Mario Hervault, Cheol Soh, Jan R Wessel","doi":"10.1016/j.cortex.2024.12.005","DOIUrl":"https://doi.org/10.1016/j.cortex.2024.12.005","url":null,"abstract":"<p><p>The ability to stop already-initiated actions is paramount to adaptive behavior. In psychology and neuroscience alike, action-stopping is a popular model behavior to probe inhibitory control - the underlying cognitive control process that is purportedly vital to regulating thoughts and actions. Starting with seminal work in the 1990s, the frontocentral stop-signal P3 - an event-related potential derived from scalp EEG - has been proposed as a neurophysiological index of inhibitory control during action-stopping. However, this association has been challenged repeatedly over recent years. Here, we perform a critical review of both the evidence in support of the association between this P3 index and inhibitory control, as well as its documented criticisms. We first comprehensively review literature from the past three decades that suggested a link between stop-signal P3 and inhibitory control. Second, we then replicate the key empirical patterns reported in that body of literature in a uniquely large stop-signal task EEG dataset (N = 255). Third, we then examine the criticisms raised against the view of P3 as an index of inhibitory control and evaluate the evidence supporting these arguments. Finally, we present an updated view of the process(es) reflected in the stop-signal P3. Specifically, we propose that the stop-signal P3 indexes a specific, selective inhibitory control process that critically contributes to action-stopping. This view is motivated by recent two-stage models of inhibitory control and emerging empirical data. Together, we hope to clarify the process(es) reflected in the stop-signal P3 and resolve the ongoing debates regarding its utility as an index of inhibitory control during action-stopping.</p>","PeriodicalId":10758,"journal":{"name":"Cortex","volume":"183 ","pages":"232-250"},"PeriodicalIF":3.2,"publicationDate":"2024-12-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142926837","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Visual short-term memory binding and attentional processes during object-scene integration are preserved in mild cognitive impairment.","authors":"Elena Allegretti, Marika Mauti, Moreno I Coco","doi":"10.1016/j.cortex.2024.12.002","DOIUrl":"https://doi.org/10.1016/j.cortex.2024.12.002","url":null,"abstract":"<p><p>Binding, a critical cognitive process likely mediated by attention, is essential for creating coherent object representations within a scene. This process is vulnerable in individuals with dementia, who exhibit deficits in visual working memory (VWM) binding, primarily tested using abstract arrays of standalone objects. To explore how binding operates in more realistic settings across the lifespan, we examined the impact of object saliency and semantic consistency on VWM binding and the role of overt attention. Using an eye-tracking change detection task, we compared younger adults, healthy older adults, and individuals with Mild Cognitive Impairment (MCI). Participants were presented with naturalistic scenes and asked to detect changes in the identity and/or location of objects that were either semantically consistent or inconsistent with their scene context. Across all age groups, semantically inconsistent objects were prioritised during encoding, leading to better change detection than consistent objects. Highly salient objects decreased the inconsistency advantage while being detrimental to detection accuracy when inspected at longer latencies to the first fixation. Longer fixation durations on the critical object were beneficial for recognition. In contrast, delayed initial inspection or frequent subsequent fixations on other objects were detrimental to detection, regardless of age or cognitive impairment. These findings challenge the notion of generalised semantic memory impairment in the prodromal stages of dementia and highlight the importance of efficient attentional control in supporting VWM binding, even in the face of cognitive decline. Overall, preserved low-level and high-level mechanisms of object-scene integration can compensate for age-related cognitive decline, enabling successful binding in naturalistic contexts.</p>","PeriodicalId":10758,"journal":{"name":"Cortex","volume":" ","pages":""},"PeriodicalIF":3.2,"publicationDate":"2024-12-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142913840","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"An insight from the default mode network in patients with amnesia following left thalamic infarction involving the mediodorsal nucleus and mammillothalamic tract.","authors":"Lola Danet, Emmanuel J Barbeau, Marie Lafuma, Fabrice Bonneville, Igor Sibon, Jean-François Albucher, Jérémie Pariente, Patrice Peran","doi":"10.1016/j.cortex.2024.10.024","DOIUrl":"https://doi.org/10.1016/j.cortex.2024.10.024","url":null,"abstract":"<p><p>The role of the medial part of the thalamus, and in particular the mediodorsal nucleus (MD) and the mammillothalamic tract (MTT), in memory has long been studied, but their contribution remains unclear. While the main functional hypothesis regarding the MTT focuses on memory, some authors postulate that the MD plays a supervisory executive role (indirectly affecting memory retrieval) due to its dense structural connectivity with the prefrontal cortex (PFC). Recently, it has been proposed that the MD, MTT and PFC form part of the DMN the default mode network (DMN). Due to the theoretical presence of MD and MTT in the DMN, we aimed to show the effect of thalamic lesions on functional connectivity (FC) and its putative role in cognitive impairment. We recruited 12 patients with left thalamic infarction and 12 matched healthy controls. They underwent neuropsychological assessment including memory tasks, morphological 3D MRI and resting state fMRI. A ROI-to-ROI method was used for group-level FC analyses. Patients had lesions in the MD and ventrolateral nuclei, with a damaged mammillothalamic tract (MTT) in seven of them. They showed lower performance than controls on verbal memory, executive function and language tests, with more impairment in memory, working memory, semantic verbal fluency and attention in the MTT-damaged patients. Contrast analyses between patients and matched controls showed lower FC in the ventral and dorsal DMN. Correlation analyses (patients and controls pooled) showed i/a positive correlation between memory and DMN, and ii/that MTT volume correlated with decreased functional connectivity in the dorsal DMN, whereas there was no correlation with MD lesion volume. These results suggest that both the memory impairment and the DMN functional change we observed may reflect an effect of the MTT lesion rather than MD damage.</p>","PeriodicalId":10758,"journal":{"name":"Cortex","volume":"183 ","pages":"220-231"},"PeriodicalIF":3.2,"publicationDate":"2024-12-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142909367","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Associations between genetic variations in oxytocin pathway genes and hippocampal volume: Insights from the UK Biobank.","authors":"Shanshan Xiao, Natalie C Ebner, Junhua Dang, Gull Rukh, Lars Westberg, Helgi B Schiöth, Håkan Fischer","doi":"10.1016/j.cortex.2024.11.017","DOIUrl":"https://doi.org/10.1016/j.cortex.2024.11.017","url":null,"abstract":"<p><p>The role of oxytocin-related genes in social-cognitive function has been previously established, but structural brain mechanisms underlying this link remain poorly understood. Utilizing a substantial dataset from the UK Biobank (N ≈ 30,000), this research determined associations between variations in ten single nucleotide polymorphisms (SNPs) within three oxytocin pathway genes (i.e., the oxytocin/neurophysin I prepropetide gene, the cluster of differentiation 38 glycoprotein gene, the oxytocin receptor gene) and whole-brain gray matter volume. Carriers of the AA or AG genotypes of the oxytocin receptor gene rs237851 SNP exhibited significantly larger hippocampal volume than carriers of the GG genotype. These results support the link between variations in the oxytocin receptor gene and hippocampal structure, with possible impact on social-cognitive function such as social recognition memory.</p>","PeriodicalId":10758,"journal":{"name":"Cortex","volume":"183 ","pages":"211-219"},"PeriodicalIF":3.2,"publicationDate":"2024-12-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142906645","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Linking structural and functional changes during healthy aging and semantic dementia using multilayer brain network analysis.","authors":"Gwendolyn Jauny, Marine Le Petit, Shailendra Segobin, Catherine Merck, Serge Belliard, Francis Eustache, Mickael Laisney, Thomas Hinault","doi":"10.1016/j.cortex.2024.11.013","DOIUrl":"https://doi.org/10.1016/j.cortex.2024.11.013","url":null,"abstract":"<p><p>Healthy aging is characterized by frontal and diffuse brain changes, while certain age-related pathologies such as semantic dementia will be associated with more focal brain lesions, particularly in the temporo-parietal regions. These changes in structural integrity could influence functional brain networks. Here we use multilayer brain network analysis on structural (DWI) and functional (fMRI) data in younger and older healthy individuals and patients with semantic dementia. Relative to younger adults, results revealed lower levels of similarity of connectivity patterns between brain structure and function, and an increased network clustering in frontal regions in healthy older individuals. These changes were either associated with a preservation (similarity) and a decrease (clustering) in cognitive performance. Patients with semantic dementia showed an increase in the similarity of structural and functional connectivity patterns, as well as an increase in clustering in temporo-parietal regions. These changes were respectively associated with a preservation and a decrease in cognitive performance. These results provide a better characterization of distinct profiles of age- and pathology-brain network changes and their association with the preservation or the decline of cognitive functions.</p>","PeriodicalId":10758,"journal":{"name":"Cortex","volume":" ","pages":""},"PeriodicalIF":3.2,"publicationDate":"2024-12-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142892685","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Complex memories induced by intracranial electrical brain stimulation are related to complex networks.","authors":"Jonathan Curot, Vincent Dornier, Luc Valton, Marie Denuelle, Alexis Robin, Florence Rulquin, Jean-Christophe Sol, Amaury De Barros, Agnès Trébuchon, Christian Bénar, Fabrice Bartolomei, Emmanuel J Barbeau","doi":"10.1016/j.cortex.2024.11.015","DOIUrl":"https://doi.org/10.1016/j.cortex.2024.11.015","url":null,"abstract":"<p><p>The precise and fleeting moment of rich recollection triggered by an environmental cue is difficult to reproduce in the lab. However, epilepsy patients can experience sudden reminiscences after intracranial electrical brain stimulation (EBS). In these cases, the transient brain state related to the activation of the engram and its conscious perception can be recorded using intracerebral EEG (iEEG). We collected various EBS-induced reminiscences for iEEG analysis, classifying them as follows: no or weak details (familiarity); moderate details and context (semantic and personal semantic memories); high details and context (episodic). Nine brain areas were selected within the temporal lobes (including the hippocampus and temporal neocortex, ipsi- and contralateral) and the insula, defining a network (each area as a node). Functional connectivity was measured by estimating pair-wise non-linear correlations between signals recorded from these brain regions during different memory events. Seventeen reminiscences in six patients (2 episodic, 10 personal semantic, 2 semantic memories, 5 familiar objects, 1 déjà-rêvé) were compared to 18 control experiential phenomena (unrelated to reminiscence), 18 negative EBS (which failed to elicit memories or other phenomena) in the same locations, and pre-EBS baseline activity. The global functional connectivity in the network was higher following EBS-induced reminiscences than during baseline activity, control phenomena, or negative EBS. The degree of connectivity increased with the complexity of memories; it was higher for detailed and contextualized memories like episodic memories. More significant links compared to baseline (edges with higher non-linear correlation relative to baseline) were observed for episodic memories than for less contextualized memories. These increases in connectivity occurred in all frequency bands, except the delta band. Our results support understanding declarative memory retrieval as having a multiplexed organization. They also show that richer memories activated by intracranial EBS are related to more complex connectivity patterns across medial and neocortical temporal lobe structures.</p>","PeriodicalId":10758,"journal":{"name":"Cortex","volume":" ","pages":""},"PeriodicalIF":3.2,"publicationDate":"2024-12-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142909365","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}